FB2019_05, released Oct 15, 2019

Gene: Dmel\MRP

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General Information
Symbol
Dmel\MRP
Species
D. melanogaster
Name
Multidrug-Resistance like Protein 1
Annotation Symbol
CG6214
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032456
Gene Model Status
Current
Stock Availability
14 publicly available
Enzyme Name (EC)
Adenosinetriphosphatase (3.6.1.3)
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Also Known As
dMRP, MRP1, dMRP/CG6214, lincRNA.123
Key Links
Genomic Location
Cytogenetic map
33F3-33F5
Sequence location
2L:12,719,045..12,766,546 [+]
Recombination map
2-47
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
ATPase-coupled inorganic anion transmembrane transporter activity
Predictions / Assertions
ATP binding; ATPase activity; ATPase-coupled transmembrane transporter activity
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + H(2)O = ADP + phosphate (3.6.1.3)
Summaries
Gene Group (FlyBase)
ABCC ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY -
The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCC subfamily are full transporters, encoding the functional transporter in one polypeptide. In humans some members of this class are associated with multidrug resistance. (Adapted from FBrf0224053).
Gene Model and Products
Number of Transcripts
18
Number of Unique Polypeptides
17

Please see the GBrowse view of Dmel\MRP or the JBrowse view of Dmel\MRP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Release 3.2: multiple alternative transcripts based on variable exon cassettes as per FBrf0158935.
Annotated transcripts may not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Gene model reviewed during 6.03
Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
MRP-RA
FBtr0090013
NM_165020
5444
1549
MRP-RB
FBtr0090014
NM_135747
5436
1548
MRP-RC
FBtr0090015
NM_205977
5555
1548
MRP-RD
FBtr0090016
NM_205976
5437
1548
MRP-RE
FBtr0090017
NM_205975
5437
1548
MRP-RF
FBtr0090018
NM_205974
5437
1548
MRP-RG
FBtr0090019
NM_205973
5555
1548
MRP-RH
FBtr0090020
NM_205972
5437
1548
MRP-RI
FBtr0090021
NM_205971
5440
1549
MRP-RJ
FBtr0090022
NM_205970
5555
1548
MRP-RK
FBtr0090023
NM_205969
5555
1548
MRP-RL
FBtr0090024
NM_205968
5437
1548
MRP-RM
FBtr0090025
NM_205982
5555
1548
MRP-RN
FBtr0090026
NM_205981
5555
1548
MRP-RO
FBtr0090027
NM_205980
5558
1549
MRP-RP
FBtr0090028
NM_205979
5555
1548
MRP-RQ
FBtr0090029
NM_205978
5437
1548
MRP-RR
FBtr0347485
NM_001316390
5042
1492
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
MRP-PA
FBpp0089056
173.4
1549
6.37
NP_723772
AAF53223
MRP-PB
FBpp0089057
173.4
1548
7.00
NP_609591
AAG22430
MRP-PC
FBpp0089058
173.2
1548
6.80
NP_995699
AAS64688
MRP-PD
FBpp0089059
173.6
1548
6.80
NP_995698
AAS64685
MRP-PE
FBpp0089060
173.5
1548
6.83
NP_995697
AAS64686
MRP-PF
FBpp0089061
173.7
1548
6.70
NP_995696
AAS64687
MRP-PG
FBpp0089062
173.4
1548
6.85
NP_995695
AAS64690
MRP-PH
FBpp0089063
173.3
1548
6.57
NP_995694
AAS64692
MRP-PI
FBpp0089064
173.6
1549
6.53
NP_995693
AAS64696
MRP-PJ
FBpp0089065
173.8
1548
7.00
NP_995692
AAS64693
MRP-PK
FBpp0089066
173.9
1548
6.89
NP_995691
AAS64695
MRP-PL
FBpp0089067
173.6
1548
7.04
NP_995690
AAS64697
MRP-PM
FBpp0089068
173.5
1548
6.74
NP_995704
AAS64699
MRP-PN
FBpp0089069
173.7
1548
7.03
NP_995703
AAS64694
MRP-PO
FBpp0089070
173.4
1549
6.37
NP_995702
AAS64689
MRP-PP
FBpp0089071
173.6
1548
7.12
NP_995701
AAS64691
MRP-PQ
FBpp0089072
173.8
1548
7.40
NP_995700
AAS64698
MRP-PR
FBpp0312572
167.6
1492
7.26
NP_001303319
ALI30205
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1549 aa isoforms: MRP-PA, MRP-PO
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MRP using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (11 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
ATPase-coupled inorganic anion transmembrane transporter activity
inferred from direct assay
(Tarnay et al., 2004)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
ATPase activity
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
ATPase-coupled transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
anion transmembrane transport
inferred from direct assay
(Tarnay et al., 2004)
renal tubular secretion
inferred from expression pattern
(Chahine and O'Donnell, 2009)
response to toxic substance
inferred from expression pattern
(Chahine and O'Donnell, 2010, Chahine and O'Donnell, 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
integral component of plasma membrane
inferred from direct assay
(Tarnay et al., 2004)
plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
membrane
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
integral component of plasma membrane
inferred from direct assay
(Tarnay et al., 2004)
plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\MRP in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of MRP
Transgenic constructs containing regulatory region of MRP
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
Sterility
Allele
fertile
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ABCC3
14 of 15
Yes
Yes
Hsap\ABCC1
10 of 15
No
Yes
 
Hsap\ABCC2
7 of 15
No
Yes
Hsap\ABCC6
6 of 15
No
Yes
Hsap\ABCC4
3 of 15
No
No
 
Hsap\ABCC5
3 of 15
No
No
 
Hsap\ABCC8
3 of 15
No
No
Hsap\ABCC9
3 of 15
No
No
Hsap\ABCC10
3 of 15
No
No
Hsap\ABCC11
3 of 15
No
Yes
Hsap\ABCC12
3 of 15
No
Yes
Hsap\LOC105369239
2 of 15
No
Yes
Hsap\CFTR
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Abcc1
12 of 15
Yes
Yes
Mmus\Abcc3
11 of 15
No
Yes
Mmus\Abcc2
6 of 15
No
Yes
Mmus\Abcc6
6 of 15
No
Yes
Mmus\Abcc4
3 of 15
No
No
Mmus\Abcc5
3 of 15
No
No
Mmus\Abcc8
3 of 15
No
No
Mmus\Abcc9
3 of 15
No
No
Mmus\Abcc10
3 of 15
No
No
Mmus\Abcc12
3 of 15
No
Yes
Mmus\Cftr
1 of 15
No
No
Rattus norvegicus (Norway rat) (12)
Rnor\Abcc3
10 of 13
Yes
Yes
Rnor\Abcc1
8 of 13
No
Yes
Rnor\Abcc6
6 of 13
No
Yes
Rnor\Abcc2
5 of 13
No
Yes
Rnor\Abcc5
3 of 13
No
Yes
Rnor\Abcc10
3 of 13
No
No
Rnor\Abcc4
2 of 13
No
No
Rnor\Abcc8
2 of 13
No
No
Rnor\Abcc9
2 of 13
No
No
Rnor\Abcc12
2 of 13
No
Yes
Rnor\LOC688708
1 of 13
No
Yes
Rnor\LOC103693258
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (7)
Xtro\abcc3
10 of 12
Yes
Yes
Xtro\abcc6
4 of 12
No
Yes
Xtro\abcc1
3 of 12
No
Yes
Xtro\abcc2
1 of 12
No
Yes
Xtro\abcc4
1 of 12
No
No
Xtro\abcc10
1 of 12
No
No
Xtro\cftr
1 of 12
No
No
Danio rerio (Zebrafish) (16)
Drer\abcc1
10 of 15
Yes
Yes
Drer\abcc6a
9 of 15
No
Yes
Drer\abcc3
5 of 15
No
Yes
Drer\abcc2
4 of 15
No
Yes
Drer\abcc6b.2
4 of 15
No
Yes
Drer\abcc5
3 of 15
No
Yes
Drer\abcc9
3 of 15
No
No
Drer\abcc10
3 of 15
No
No
Drer\abcc12
3 of 15
No
No
Drer\abcc4
2 of 15
No
No
Drer\abcc8b
2 of 15
No
Yes
Drer\abcc8
2 of 15
No
No
Drer\abcc13
1 of 15
No
No
Drer\cftr
1 of 15
No
No
Drer\cry1bb
1 of 15
No
No
Drer\fam212aa
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\mrp-1
12 of 15
Yes
Yes
Cele\mrp-2
12 of 15
Yes
Yes
Cele\mrp-3
8 of 15
No
Yes
Cele\mrp-4
8 of 15
No
Yes
Cele\mrp-7
8 of 15
No
Yes
Cele\mrp-8
6 of 15
No
Yes
Cele\cft-1
2 of 15
No
Yes
Cele\mrp-5
2 of 15
No
No
Cele\mrp-6
2 of 15
No
No
Arabidopsis thaliana (thale-cress) (15)
Atha\ABCC1
7 of 9
Yes
Yes
Atha\ABCC2
7 of 9
Yes
Yes
Atha\ABCC11
5 of 9
No
Yes
Atha\ABCC12
5 of 9
No
Yes
Atha\ABCC3
4 of 9
No
Yes
Atha\ABCC4
4 of 9
No
Yes
Atha\ABCC6
4 of 9
No
Yes
Atha\ABCC9
4 of 9
No
Yes
Atha\ABCC10
4 of 9
No
Yes
Atha\ABCC14
4 of 9
No
Yes
Atha\ABCC15
4 of 9
No
Yes
Atha\ABCC5
3 of 9
No
Yes
Atha\ABCC7
3 of 9
No
Yes
Atha\ABCC8
3 of 9
No
Yes
Atha\ABCC13
3 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\YCF1
14 of 15
Yes
Yes
Scer\BPT1
7 of 15
No
Yes
Scer\NFT1
4 of 15
No
Yes
Scer\YBT1
4 of 15
No
No
Scer\VMR1
3 of 15
No
Yes
Scer\YOR1
3 of 15
No
No
Scer\YKR104W
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\abc2
11 of 12
Yes
Yes
Spom\abc3
10 of 12
No
Yes
Spom\abc4
1 of 12
No
No
Spom\ybt1
1 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900IC )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\MRP
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008466
Drosophila simulans
Dsim\GD23852
Drosophila sechellia
Dsec\GM10053
Drosophila erecta
Dere\GG23797
Drosophila yakuba
Dyak\GE18601
Drosophila ananassae
Dana\GF14209
Drosophila pseudoobscura pseudoobscura
Dpse\GA19445
Drosophila willistoni
Dwil\GK24436
Drosophila virilis
Dvir\GJ16281
Drosophila mojavensis
Dmoj\GI14505
Drosophila grimshawi
Dgri\GH13214
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915008J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023962
Glossina morsitans
Tsetse fly
Gmor\GMOY012006
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12503
Mayetiola destructor
Hessian fly
Mdes\Mdes003527
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005045
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005043
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004743
Anopheles darlingi
American malaria mosquito
Adar\ADAC005414
Anopheles darlingi
American malaria mosquito
Adar\ADAC005413
Anopheles darlingi
American malaria mosquito
Adar\ADAC010102
Anopheles gambiae
Malaria mosquito
Agam\AGAP028128
Anopheles gambiae
Malaria mosquito
Agam\AGAP009835
Anopheles gambiae
Malaria mosquito
Agam\AGAP012735
Anopheles gambiae
Malaria mosquito
Agam\AGAP008437
Anopheles gambiae
Malaria mosquito
Agam\AGAP027980
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011958
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011963
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001520
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00X0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007735
Bombyx mori
Silkmoth
Bmor\BGIBMGA010330
Bombyx mori
Silkmoth
Bmor\BGIBMGA011220
Bombyx mori
Silkmoth
Bmor\BGIBMGA007738
Bombyx mori
Silkmoth
Bmor\BGIBMGA010332
Bombyx mori
Silkmoth
Bmor\BGIBMGA010849
Bombyx mori
Silkmoth
Bmor\BGIBMGA003359
Danaus plexippus
Monarch butterfly
Dple\DPOGS208713-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208066-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208634-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208494-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208084-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208065-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203074-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202687-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008762
Heliconius melpomene
Postman butterfly
Hmel\HMEL015261
Heliconius melpomene
Postman butterfly
Hmel\HMEL003355
Heliconius melpomene
Postman butterfly
Hmel\HMEL011589
Heliconius melpomene
Postman butterfly
Hmel\HMEL003354
Heliconius melpomene
Postman butterfly
Hmel\HMEL011731
Heliconius melpomene
Postman butterfly
Hmel\HMEL003351
Heliconius melpomene
Postman butterfly
Hmel\HMEL014185
Apis florea
Little honeybee
Aflo\2214844468
Apis florea
Little honeybee
Aflo\2589023892
Apis florea
Little honeybee
Aflo\2315419124
Apis florea
Little honeybee
Aflo\2155303284
Apis florea
Little honeybee
Aflo\2379350372
Apis mellifera
Western honey bee
Amel\GB43189
Apis mellifera
Western honey bee
Amel\LOC551061
Apis mellifera
Western honey bee
Amel\GB53134
Apis mellifera
Western honey bee
Amel\GB48573
Apis mellifera
Western honey bee
Amel\GB50195
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18350
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21252
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22500
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14830
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21060
Bombus terrestris
Buff-tailed bumblebee
Bter\15205612
Bombus terrestris
Buff-tailed bumblebee
Bter\15215779
Bombus terrestris
Buff-tailed bumblebee
Bter\15212604
Bombus terrestris
Buff-tailed bumblebee
Bter\15211279
Bombus terrestris
Buff-tailed bumblebee
Bter\15211632
Linepithema humile
Argentine ant
Lhum\LH25761
Linepithema humile
Argentine ant
Lhum\LH22562
Linepithema humile
Argentine ant
Lhum\LH12079
Linepithema humile
Argentine ant
Lhum\LH15915
Linepithema humile
Argentine ant
Lhum\LH22565
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000168
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0000ee
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00011e
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00205d
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002038
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005769
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014001
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007473
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005619
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011110
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005949
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008391
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005944
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005771
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001436
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022099
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001435
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005946
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001437
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04278
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03598
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05102
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03994
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08194
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06255
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08305
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06244
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02982
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03090
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07647
Tribolium castaneum
Red flour beetle
Tcas\TC013751
Tribolium castaneum
Red flour beetle
Tcas\TC014092
Tribolium castaneum
Red flour beetle
Tcas\TC009892
Tribolium castaneum
Red flour beetle
Tcas\TC014383
Tribolium castaneum
Red flour beetle
Tcas\TC009891
Tribolium castaneum
Red flour beetle
Tcas\TC014089
Tribolium castaneum
Red flour beetle
Tcas\TC014589
Tribolium castaneum
Red flour beetle
Tcas\TC014775
Tribolium castaneum
Red flour beetle
Tcas\TC013750
Tribolium castaneum
Red flour beetle
Tcas\TC014403
Tribolium castaneum
Red flour beetle
Tcas\TC014090
Tribolium castaneum
Red flour beetle
Tcas\TC033612
Tribolium castaneum
Red flour beetle
Tcas\TC010434
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15346
Tribolium castaneum
Red flour beetle
Tcas\TC033390
Tribolium castaneum
Red flour beetle
Tcas\TC014091
Tribolium castaneum
Red flour beetle
Tcas\TC008570
Tribolium castaneum
Red flour beetle
Tcas\TC014776
Tribolium castaneum
Red flour beetle
Tcas\TC012253
Tribolium castaneum
Red flour beetle
Tcas\TC034098
Tribolium castaneum
Red flour beetle
Tcas\TC013749
Tribolium castaneum
Red flour beetle
Tcas\TC013752
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_14880
Tribolium castaneum
Red flour beetle
Tcas\TC010962
Pediculus humanus
Human body louse
Phum\PHUM075990
Pediculus humanus
Human body louse
Phum\PHUM351610
Pediculus humanus
Human body louse
Phum\PHUM513390
Rhodnius prolixus
Kissing bug
Rpro\RPRC008610
Rhodnius prolixus
Kissing bug
Rpro\RPRC014278
Cimex lectularius
Bed bug
Clec\CLEC025140
Cimex lectularius
Bed bug
Clec\CLEC011933
Cimex lectularius
Bed bug
Clec\CLEC006400
Cimex lectularius
Bed bug
Clec\CLEC011936
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI23911
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI38602
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004675
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI084147
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI068671
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008842
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006979
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI070177
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007210
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000359
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002363
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008595
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI084024
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005339
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006442
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001507
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004533
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006066
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001390
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01907
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11998
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01434
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09464
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02081
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09949
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02052
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09948
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0183 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008549
Strigamia maritima
European centipede
Smar\SMAR006496
Strigamia maritima
European centipede
Smar\SMAR008548
Strigamia maritima
European centipede
Smar\SMAR006498
Strigamia maritima
European centipede
Smar\SMAR011036
Strigamia maritima
European centipede
Smar\SMAR011133
Strigamia maritima
European centipede
Smar\SMAR011077
Strigamia maritima
European centipede
Smar\SMAR005358
Ixodes scapularis
Black-legged tick
Isca\ISCW007915
Ixodes scapularis
Black-legged tick
Isca\ISCW021900
Ixodes scapularis
Black-legged tick
Isca\ISCW018516
Ixodes scapularis
Black-legged tick
Isca\ISCW019069
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57967.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75623.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82636.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80877.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur16g03480
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g04610
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02300
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02310
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g04410
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g01110
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g07860
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g02060
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02290
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g01950
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g00590
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g05540
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g15310
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02330
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g00280
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g00580
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g07910
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09880
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g10390
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02320
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g02240
Tetranychus urticae
Two-spotted spider mite
Turt\tetur40g00010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g00220
Tetranychus urticae
Two-spotted spider mite
Turt\tetur23g02452
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g07880
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g07490
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g04360
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g03510
Tetranychus urticae
Two-spotted spider mite
Turt\tetur25g01780
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g15340
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g00360
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g04620
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g02120
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09800
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g04290
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g04300
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g03560
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g15330
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347288
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347281
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00IN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4e
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9e
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mrpl
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc3a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9k
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9f
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9i
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9c
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9h
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sur1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc10a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4d
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_015053gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9j
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-ABCC9g
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9l
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4c
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc1b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc10b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9d
Ciona intestinalis
Vase tunicate
Cint\LOC100185468
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006107
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007551
Gallus gallus
Domestic chicken
Ggal\ABCC4
Gallus gallus
Domestic chicken
Ggal\LOC416599
Gallus gallus
Domestic chicken
Ggal\ABCC9
Gallus gallus
Domestic chicken
Ggal\ABCC2
Gallus gallus
Domestic chicken
Ggal\ABCC3
Gallus gallus
Domestic chicken
Ggal\ABCC10
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015675
Gallus gallus
Domestic chicken
Ggal\ABCC1
Gallus gallus
Domestic chicken
Ggal\ABCC8
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (13)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG4562
5 of 10
CG5789
5 of 10
CG9270
5 of 10
CG10505
5 of 10
CG11898
5 of 10
CG31792
5 of 10
CG31793
5 of 10
rdog
5 of 10
CG7627
4 of 10
CG7806
4 of 10
l(2)03659
4 of 10
Mrp4
4 of 10
Sur
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ABCC3; ATP binding cassette subfamily C member 3
    14 of 15
    604323
        ABCC1; ATP binding cassette subfamily C member 1
        10 of 15
        158343
             
            ABCC2; ATP binding cassette subfamily C member 2
            7 of 15
            601107
            ABCC6; ATP binding cassette subfamily C member 6
            6 of 15
            603234
            ABCC4; ATP binding cassette subfamily C member 4
            3 of 15
            605250
                 
                ABCC5; ATP binding cassette subfamily C member 5
                3 of 15
                605251
                     
                    ABCC8; ATP binding cassette subfamily C member 8
                    3 of 15
                    600509
                    ABCC9; ATP binding cassette subfamily C member 9
                    3 of 15
                    601439
                    ABCC10; ATP binding cassette subfamily C member 10
                    3 of 15
                    612509
                        ABCC11; ATP binding cassette subfamily C member 11
                        3 of 15
                        607040
                          ABCC12; ATP binding cassette subfamily C member 12
                          3 of 15
                          607041
                              Functional Complementation Data
                              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                              Interactions
                              Summary of Physical Interactions
                              esyN Network Diagram
                              Show neighbor-neighbor interactions:
                              Select Layout:
                              Legend:
                              Protein
                              RNA
                              Selected Interactor(s)
                              Interactions Browser
                              View in Interactions Browser
                              Please see the Physical Interaction reports below for full details
                              protein-protein
                              Physical Interaction
                              Assay
                              References
                              MRP - Agpat3
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Alg11
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - AspRS
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Atpα
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CCT4
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CCT6
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CCT7
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CCT8
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CG10425
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CG11857
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CG13220
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CG1371
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CG2064
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CG2065
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CG3164
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CG31729
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CG33303
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CG5447
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CG7668
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - CG8195
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Cand1
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Chc
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Cnx99A
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Cyp12d1-p
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - FASN1
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Fatp1
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Frl
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Gfat2
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - GluProRS
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Gp210
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Gp93
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Idh3a
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Kap-α3
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Karyβ3
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - KdelR
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Kr-h2
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Mcad
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Mec2
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Mpcp2
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Nfs1
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Ost48
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - OstΔ
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - PMCA
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Past1
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Pen
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Pi3K68D
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Pp2A-29B
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Rab4
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Rab5
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Ranbp9
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - RpS10b
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Rpn1
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Rpt1
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - SERCA
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Sc2
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Scamp
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - ScsβG
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Sec61α
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Sec63
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - SerRS
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Spindly
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Spt-I
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Surf4
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - TER94
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - Tapδ
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - UQCR-6.4
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - UQCR-C2
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - ZnT63C
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - bor
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - emb
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - fax
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - foxo
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              MRP - jagn
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - msk
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - p23
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - porin
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - rictor
                              anti tag coimmunoprecipitation, Identification by mass spectrometry
                              (Vinayagam et al., 2016)
                              MRP - scf
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - spidey
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - sun
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - wal
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              MRP - βCOP
                              experimental knowledge based
                              (Guruharsha et al., 2011)
                              Summary of Genetic Interactions
                              esyN Network Diagram
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              External Data
                              Linkouts
                              BioGRID - A database of protein and genetic interactions.
                              DroID - A comprehensive database of gene and protein interactions.
                              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Pathways
                              Gene Group - Pathway Membership (FlyBase)
                              External Data
                              Genomic Location and Detailed Mapping Data
                              Chromosome (arm)
                              2L
                              Recombination map
                              2-47
                              Cytogenetic map
                              33F3-33F5
                              Sequence location
                              2L:12,719,045..12,766,546 [+]
                              FlyBase Computed Cytological Location
                              Cytogenetic map
                              Evidence for location
                              33F3-33F5
                              Limits computationally determined from genome sequence between P{lacW}bunk00612&P{EP}EP682EP682 and P{lacW}l(2)k07015k07015&P{PZ}l(2)rK639rK639
                              Experimentally Determined Cytological Location
                              Cytogenetic map
                              Notes
                              References
                              Experimentally Determined Recombination Data
                              Location
                              2-47
                              (FlyBase, 2016)
                              2-42.5
                              (Comeron et al., 2012)
                              Left of (cM)
                              Right of (cM)
                              Notes
                              Stocks and Reagents
                              Stocks (14)
                              Genomic Clones (19)
                               

                              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                              cDNA Clones (98)
                               

                              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                              cDNA clones, fully sequences
                              BDGP DGC clones
                              Other clones
                              Drosophila Genomics Resource Center cDNA clones

                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                              cDNA Clones, End Sequenced (ESTs)
                              BDGP DGC clones
                              Other clones
                              RNAi and Array Information
                              Linkouts
                              DRSC - Results frm RNAi screens
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              Antibody Information
                              Laboratory Generated Antibodies
                               
                              Commercially Available Antibodies
                               
                              Other Information
                              Relationship to Other Genes
                              Source for database identify of
                              Source for identity of: MRP CG6214
                              (Tarnay et al., 2004)
                              Source for database merge of
                              Additional comments
                              Other Comments
                              Origin and Etymology
                              Discoverer
                              Etymology
                              Identification
                              External Crossreferences and Linkouts ( 113 )
                              Sequence Crossreferences
                              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                              Other crossreferences
                              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                              Flygut - An atlas of the Drosophila adult midgut
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              InterPro - A database of protein families, domains and functional sites
                              KEGG Genes - Molecular building blocks of life in the genomic space.
                              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                              modMine - A data warehouse for the modENCODE project
                              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                              Linkouts
                              BioGRID - A database of protein and genetic interactions.
                              DroID - A comprehensive database of gene and protein interactions.
                              DRSC - Results frm RNAi screens
                              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                              FlyMine - An integrated database for Drosophila genomics
                              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                              Synonyms and Secondary IDs (18)
                              Reported As
                              Symbol Synonym
                              ABCC1
                              (Prince et al., 2014)
                              CG6214
                              (Kolkhof et al., 2017, Meadows, 2017.9.14, Transgenic RNAi Project members, 2017-, Çiçek et al., 2016, Dermauw and Van Leeuwen, 2014, Paulsen et al., 2013, Chahine et al., 2012, Christis and Munro, 2012, Cammarato et al., 2011, Anholt and Williams, 2010, Chahine and O'Donnell, 2010, Ni et al., 2010.12.1, Chahine and O'Donnell, 2009, Keleman et al., 2009.8.5, Mayer et al., 2009, Szeri et al., 2009, Levis, 2005.12.14, Lipatov et al., 2005, Giot et al., 2003, Herold et al., 2003, Dean et al., 2001)
                              MRP
                              (Kim et al., 2019, Kline et al., 2017, Prince and Rand, 2017, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Gene Disruption Project members, 2015-, Van Bortle et al., 2015, King et al., 2014, Vinayagam et al., 2014, Kwon et al., 2013, Chahine et al., 2012, Gurudatta et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Friedman et al., 2011, Tan et al., 2009)
                              MRP1
                              (Jin et al., 2018, Johan Arief et al., 2018, Zhan et al., 2012)
                              Mrp
                              (Faisal et al., 2014)
                              Mrp1
                              (Kim et al., 2018, Gellatly et al., 2015)
                              dMRP
                              (Karasik et al., 2018, Prince et al., 2014, Chahine and O'Donnell, 2011, Chahine and O'Donnell, 2010, Chahine and O'Donnell, 2009, Szeri et al., 2009, Tarnay-Cogbill et al., 2008, Tarnay and Robinow, 2007, Cogbill and Robinow, 2006, Tarnay et al., 2004, Grailles et al., 2003)
                              dMRP/CG6214
                              (Tarnay and Robinow, 2005, Tarnay et al., 2004)
                              dMRP1
                              (Zhan et al., 2012)
                              dmrp
                              (Sharma et al., 2018)
                              lincRNA.123
                              (FlyBase Genome Annotators, 2014, Young et al., 2012)
                              Name Synonyms
                              Multidrug-Resistance like Protein 1
                              (Cammarato et al., 2011, Tarnay et al., 2004)
                              Multidrug-Resistance like protein 1
                              (Castillo et al., 2015)
                              Multidrug-resistance protein
                              (Grailles et al., 2003)
                              multidrug resistance like protein
                              (Faisal et al., 2014)
                              multidrug resistance-associated protein
                              (Chahine and O'Donnell, 2010)
                              multidrug resistance-like protein
                              (Prince et al., 2014)
                              multidrug resistance-like protein 1
                              (Chahine and O'Donnell, 2009)
                              Secondary FlyBase IDs
                                Datasets (0)
                                Study focus (0)
                                Experimental Role
                                Project
                                Project Type
                                Title
                                References (99)