FB2022_03, released June 9, 2022

Gene: Dmel\Sfmbt

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General Information
Symbol
Dmel\Sfmbt
Species
D. melanogaster
Name
Scm-related gene containing four mbt domains
Annotation Symbol
CG16975
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032475
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Scm-related gene containing four mbt domains (Sfmbt) encodes a subunit of the Polycomb Group protein complex Pho repressive complex (PhoRC). This chromatin binding protein recognizes with high selectivity mono- and dimethylated lysine residues in various histone peptides. [Date last reviewed: 2018-11-15] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dSfmbt

Key Links
Genomic Location
Cytogenetic map
34A7-34A8
Sequence location
Recombination map
2-47
RefSeq locus
NT_033779 REGION:13169649..13176785
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Gambetta et al., 2009)
enables methylated histone binding
inferred from direct assay
(Grimm et al., 2009, Klymenko et al., 2006)
enables protein binding
inferred from physical interaction with FLYBASE:Scm; FB:FBgn0003334
(Grimm et al., 2009)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from biological aspect of ancestor with PANTHER:PTN002284114
(assigned by GO_Central )
(Gaudet et al., 2011)
enables histone binding
inferred from biological aspect of ancestor with PANTHER:PTN002284114
(assigned by GO_Central )
(Gaudet et al., 2011)
enables methylated histone binding
inferred from biological aspect of ancestor with PANTHER:PTN000749027
(assigned by GO_Central )
(Gaudet et al., 2011)
enables zinc ion binding
inferred from electronic annotation with InterPro:IPR012313
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in heterochromatin assembly
inferred from genetic interaction with FLYBASE:Scm; FB:FBgn0003334
(Grimm et al., 2009)
inferred from direct assay
(Klymenko et al., 2006)
involved_in imaginal disc growth
inferred from mutant phenotype
(Klymenko et al., 2006)
involved_in negative regulation of gene expression
inferred from mutant phenotype
(Lu et al., 2007)
involved_in oogenesis
inferred from mutant phenotype
(Klymenko et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in negative regulation of transcription, DNA-templated
inferred from biological aspect of ancestor with PANTHER:PTN002284114
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Klymenko et al., 2006)
part_of PcG protein complex
inferred from physical interaction with FLYBASE:pho; FB:FBgn0002521
(Klymenko et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002284114
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Scm-related gene containing four mbt domains (Sfmbt) encodes a subunit of the Polycomb Group protein complex Pho repressive complex (PhoRC). This chromatin binding protein recognizes with high selectivity mono- and dimethylated lysine residues in various histone peptides. [Date last reviewed: 2018-11-15]
Gene Group (FlyBase)
PHO REPRESSIVE COMPLEX -
In Drosophila, the Pho repressive complex (PhoRC) can bind Polycomb Response Elements (PREs) and recruit Polycomb repressive complexes. (Adapted from FBrf0190547 and FBrf0220020).
Protein Function (UniProtKB)
Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.
(UniProt, Q9VK33)
Summary (Interactive Fly)

PcG protein - Pleiohomeotic interactor that binds mono- and di-methylated H3-K9 and H4-K20 and acts to maintain a Polycomb-repressed chromatin state

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Sfmbt for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VK33)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sfmbt-RA
FBtr0080491
NM_165026
3939
868
Sfmbt-RB
FBtr0080492
NM_135762
4777
1220
Sfmbt-RC
FBtr0289981
NM_001144349
4846
1243
Sfmbt-RD
FBtr0333236
NM_001273503
4765
1220
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Sfmbt-PA
FBpp0080069
95.9
868
5.51
NP_723786
AAF53250
Sfmbt-PB
FBpp0080070
133.7
1220
5.17
Q9VK33
NP_609606
AAF53249
Sfmbt-PC
FBpp0288419
136.0
1243
5.42
B7YZV6
NP_001137821
ACL83027
Sfmbt-PD
FBpp0305438
133.7
1220
5.17
Q9VK33
NP_001260432
AGB92967
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1220 aa isoforms: Sfmbt-PB, Sfmbt-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with pho as a component of the pho-repressive complex (PhoRC).

(UniProt, Q9VK33)
Domain

MBT repeats have unique discriminatory binding activity for methylated Lys residues in H3 and H4; the MBT repeats bind mono- and dimethylated H3K9Me1, H3K9Me2, H4K20Me1 and H4K20Me2 but fail to interact with these residues if they are unmodified or trimethylated.

(UniProt, Q9VK33)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sfmbt using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Klymenko et al., 2006)
part_of PcG protein complex
inferred from physical interaction with FLYBASE:pho; FB:FBgn0002521
(Klymenko et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sfmbt in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sfmbt
Transgenic constructs containing regulatory region of Sfmbt
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel8029
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MBTD1
12 of 15
Yes
Yes
Hsap\L3MBTL2
10 of 15
No
Yes
Hsap\L3MBTL1
2 of 15
No
No
Hsap\L3MBTL4
2 of 15
No
No
Hsap\SCMH1
2 of 15
No
No
Hsap\SCML1
2 of 15
No
No
Hsap\SCML2
2 of 15
No
No
Hsap\SCML4
2 of 15
No
No
1  
Hsap\SFMBT1
2 of 15
No
Yes
Hsap\SFMBT2
2 of 15
No
Yes
Hsap\L3MBTL3
1 of 15
No
No
Hsap\MIR3605
1 of 15
No
Yes
Hsap\PHC1
1 of 15
No
No
Hsap\SAMD7
1 of 15
No
No
Hsap\SAMD11
1 of 15
No
No
Hsap\SAMD13
1 of 15
No
No
Hsap\THAP10
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Mbtd1
11 of 15
Yes
Yes
Mmus\L3mbtl2
10 of 15
No
Yes
Mmus\L3mbtl4
3 of 15
No
No
Mmus\L3mbtl1
2 of 15
No
No
Mmus\L3mbtl3
2 of 15
No
No
Mmus\Scmh1
2 of 15
No
No
Mmus\Scml2
2 of 15
No
No
Mmus\Scml4
2 of 15
No
No
Mmus\Sfmbt1
2 of 15
No
Yes
Mmus\Sfmbt2
2 of 15
No
Yes
Mmus\4930503B20Rik
1 of 15
No
No
Mmus\Phc1
1 of 15
No
No
Mmus\Phc2
1 of 15
No
No
Mmus\Samd1
1 of 15
No
No
Mmus\Samd7
1 of 15
No
No
Mmus\Samd11
1 of 15
No
No
Rattus norvegicus (Norway rat) (13)
Rnor\L3mbtl2
9 of 13
Yes
Yes
Rnor\Mbtd1
4 of 13
No
Yes
Rnor\L3mbtl1
2 of 13
No
No
Rnor\Scmh1
2 of 13
No
No
Rnor\Scml2
2 of 13
No
No
Rnor\Scml4
2 of 13
No
No
Rnor\Sfmbt1
2 of 13
No
Yes
Rnor\Sfmbt2
2 of 13
No
Yes
Rnor\L3mbtl3
1 of 13
No
No
Rnor\Phc1
1 of 13
No
No
Rnor\Phc2
1 of 13
No
No
Rnor\Samd7
1 of 13
No
No
Rnor\Samd11
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\mbtd1
10 of 12
Yes
Yes
Xtro\l3mbtl3
3 of 12
No
No
Xtro\l3mbtl1
2 of 12
No
No
Xtro\scmh1
2 of 12
No
No
Xtro\scml2
2 of 12
No
No
Xtro\scml4
2 of 12
No
No
Xtro\sfmbt2
2 of 12
No
Yes
Xtro\l3mbtl2
1 of 12
No
Yes
Xtro\phc2
1 of 12
No
No
Xtro\samd7
1 of 12
No
No
Xtro\samd13
1 of 12
No
Yes
Danio rerio (Zebrafish) (16)
Drer\l3mbtl2
11 of 15
Yes
Yes
Drer\mbtd1
11 of 15
Yes
Yes
Drer\l3mbtl1b
2 of 15
No
No
Drer\l3mbtl1
2 of 15
No
No
Drer\l3mbtl3
2 of 15
No
No
Drer\l3mbtl4
2 of 15
No
No
Drer\scml4
2 of 15
No
No
Drer\sfmbt1
2 of 15
No
Yes
Drer\sfmbt2
2 of 15
No
No
Drer\LOC101883783
1 of 15
No
Yes
Drer\phc1
1 of 15
No
No
Drer\samd1b
1 of 15
No
No
Drer\samd7
1 of 15
No
No
Drer\samd11
1 of 15
No
No
Drer\samd13
1 of 15
No
No
Drer\scml2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\lin-61
9 of 15
Yes
Yes
Cele\mbtr-1
7 of 15
No
Yes
Cele\K02F6.7
1 of 15
No
Yes
Cele\sor-3
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
l(3)mbt
3 of 10
Scm
3 of 10
ph-d
2 of 10
ph-p
2 of 10
CG2662
1 of 10
Samuel
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MBTD1; mbt domain containing 1
    12 of 15
    618705
        L3MBTL2; L3MBTL histone methyl-lysine binding protein 2
        10 of 15
        611865
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Sfmbt
            pull down, autoradiography
            (Stielow et al., 2008)
            Sfmbt - HDAC1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Alfieri et al., 2013)
            Sfmbt - HP1b
            anti tag coimmunoprecipitation, peptide massfingerprinting, western blot
            (Alfieri et al., 2013)
            Sfmbt - His3
            fluorescence polarization spectroscopy, isothermal titration calorimetry
            (Grimm et al., 2009, Klymenko et al., 2006)
            Sfmbt - His4
            isothermal titration calorimetry, x-ray crystallography, fluorescence polarization spectroscopy
            (Alfieri et al., 2013, Grimm et al., 2009, Klymenko et al., 2006)
            Sfmbt - MEP-1
            pull down, autoradiography
            (Stielow et al., 2008)
            Sfmbt - Mi-2
            pull down, autoradiography
            (Stielow et al., 2008)
            Sfmbt - Nap1
            anti tag coimmunoprecipitation, western blot, peptide massfingerprinting
            (Alfieri et al., 2013)
            Sfmbt - Pc
            tandem affinity purification, Identification by mass spectrometry, pull down, western blot, peptide massfingerprinting
            (Kang et al., 2015, Strübbe et al., 2011)
            Sfmbt - Scm
            anti tag coimmunoprecipitation, western blot, x-ray crystallography, molecular weight estimation by staining, molecular sieving, pull down, tandem affinity purification, Identification by mass spectrometry
            (Frey et al., 2016, Kang et al., 2015, Grimm et al., 2009)
            Sfmbt - Sumo
            pull down, autoradiography
            (Stielow et al., 2008)
            Sfmbt - ocm
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Alfieri et al., 2013)
            Sfmbt - ph-d
            anti tag coimmunoprecipitation, western blot, peptide massfingerprinting
            (Frey et al., 2016)
            Sfmbt - ph-p
            anti tag coimmunoprecipitation, peptide massfingerprinting, molecular weight estimation by staining
            (Frey et al., 2016)
            Sfmbt - pho
            anti tag coimmunoprecipitation, peptide massfingerprinting, western blot, pull down, molecular weight estimation by staining, anti bait coimmunoprecipitation, surface plasmon resonance, isothermal titration calorimetry, anti tag western blot, x-ray crystallography, molecular sieving
            (Pereira and Paro, 2017, Alfieri et al., 2013, Strübbe et al., 2011, Klymenko et al., 2006)
            Sfmbt - phol
            anti tag coimmunoprecipitation, molecular weight estimation by staining, anti bait coimmunoprecipitation, western blot
            (Klymenko et al., 2006)
            Sfmbt - rept
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Alfieri et al., 2013)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            rpr
            enhanceable
            Sfmbt
            (Harris et al., 2020)
            External Data
            Subunit Structure (UniProtKB)
            Interacts with pho as a component of the pho-repressive complex (PhoRC).
            (UniProt, Q9VK33 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-47
            Cytogenetic map
            34A7-34A8
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            34A7-34A8
            Limits computationally determined from genome sequence between P{lacW}l(2)k11328k11328&P{lacW}l(2)k10105k10105 and P{EP}EP850&P{lacW}l(2)k05911k05911
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            2-47

            (FlyBase, 2016)

            2-43.6

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (7)
            Genomic Clones (18)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (60)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Erokhin et al., 2021, Erokhin et al., 2013, Klymenko et al., 2006)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: Sfmbt CG16975

              (Klymenko et al., 2006)
              Source for database merge of
              Additional comments
              Other Comments

              The 'PhoRC' (pho-Sfmbt) complex binds PREs via the pho protein and methylated histones in the chromatin flanking the PREs via the Sfmbt protein to maintain a repressed chromatin state.

              (Klymenko et al., 2006)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 56 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              modMine - A data warehouse for the modENCODE project
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (7)
              Reported As
              Symbol Synonym
              CG16975
              (Ni et al., 2010.12.1, Perkins et al., 2009, Haussmann et al., 2008, Stielow et al., 2008, Lu et al., 2007, Klymenko et al., 2006)
              SFMBT
              (Ho et al., 2014, Kahn et al., 2014, Bonasio et al., 2010, Schwartz and Pirrotta, 2007)
              Sfmbt
              (Fischer et al., 2022, Elizarev et al., 2021, Erokhin et al., 2021, Barbour et al., 2020, Chetverina et al., 2020, Harris et al., 2020, Kennison, 2020.10.22, Onishi et al., 2020, Bonnet et al., 2019, Cheutin and Cavalli, 2019, Alhaj Abed et al., 2018, Levis, 2018.8.30, Ma et al., 2018, Zhu et al., 2018, Monribot-Villanueva et al., 2017, Kahn et al., 2016, Bajusz et al., 2015, Erokhin et al., 2015, Kang et al., 2015, Gonzalez et al., 2014, McElroy et al., 2014, Alfieri et al., 2013, Aloia et al., 2013, Erokhin et al., 2013, Moshkin et al., 2013, Follmer et al., 2012, Islam et al., 2011, Kolaczkowski et al., 2011, Pruteanu-Malinici et al., 2011, Saj et al., 2010, Stielow et al., 2008, Grimm et al., 2007, Klymenko et al., 2006)
              dSFMBT
              (Decourcelle et al., 2019, Rennie et al., 2018, Comoglio and Paro, 2014, Lanzuolo and Orlando, 2012, Moshkin et al., 2009)
              dSfmbt
              (Chetverina et al., 2019, Monribot-Villanueva et al., 2017, Pereira and Paro, 2017, Na et al., 2015, Alic et al., 2011, Richter et al., 2011, Strübbe et al., 2011, Gambetta et al., 2009, Gambetta et al., 2009, Grimm et al., 2009, Huang et al., 2008, Oktaba et al., 2008, Lu et al., 2007, Klymenko et al., 2006, Muller and Kassis, 2006, Papp and Muller, 2006)
              sfmbt
              (DeLuca et al., 2020)
              Name Synonyms
              CG16975
              Scm-related gene containing four mbt domains
              (Comoglio and Paro, 2014, McElroy et al., 2014)
              Secondary FlyBase IDs
                Datasets (2)
                Study focus (2)
                Experimental Role
                Project
                Project Type
                Title
                • bait_protein
                modENCODE_chromatin_proteins_cells
                Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
                • bait_protein
                modENCODE_chromatin_proteins_flies
                Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.
                Study result (0)
                Result
                Result Type
                Title
                References (91)