FlyBase Gene Report: Dmel\CG16974

General Information

Symbol

Dmel\CG16974

Species

D. melanogaster

Name

Annotation Symbol

CG16974

Feature Type

protein_coding_gene

FlyBase ID

FBgn0032479

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

kekkon-like, CT35580

Key Links

Genomic Location

Cytogenetic map

34A8-34A8

Sequence location

2L:13,183,849..13,191,979 [-]

Recombination map

2-47

RefSeq locus

NT_033779 REGION:13183849..13191979

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG16974 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VK28)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Antisense UTR: Extended 3' UTR of one annotated isoform is antisense to CG5458 on the opposite strand.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

5' UTR contains an ORF described as a putative conserved uORF (FBrf0204849).

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG16974-RA

FBtr0080489

NM_135766

4365

1257

CG16974-RB

FBtr0305555

NM_001259089

5528

1257

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG16974-PA

FBpp0080067

143.1

1257

7.13

FBpp0294006

143.1

1257

7.13

Q9VK28

NP_001246018

AFH03692

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1257 aa isoforms: CG16974-PA, CG16974-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG16974 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG16974_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.42

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic myoblast

(Ulian-Benitez et al., 2017)

embryonic stage 1 -- 3

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG16974 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG16974

View exonic expression by tissue for Dmel\CG16974

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0032479

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34713/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0032479

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032479

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0032479

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16974

Flygut - An atlas of the Drosophila adult midgut

FBgn0032479

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG16974

Transgenic constructs containing regulatory region of CG16974

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel8029

(Ryder, 2004.4.26)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (72)

Hsap\ISLR2

2 of 14

Yes

Hsap\ISLR

2 of 14

Yes

Hsap\LINGO1

2 of 14

Yes

Hsap\LINGO2

2 of 14

Yes

Hsap\LINGO3

2 of 14

Yes

Hsap\LINGO4

2 of 14

Yes

Hsap\LRRC66

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\LRRC70

1 of 14

Hsap\LRRIQ1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\LRRN4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (34)

Rnor\Lingo1

2 of 14

Yes

Rnor\Lingo3

2 of 14

Yes

Rnor\Chadl

1 of 14

Rnor\Cpn2

1 of 14

Rnor\Flrt3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Lrrtm2

1 of 14

Rnor\Lrrtm3

1 of 14

Rnor\Nepn

1 of 14

Yes

Rnor\Nyx

1 of 14

Rnor\Podnl1

1 of 14

Yes

Rnor\Tril

1 of 14

Mus musculus (laboratory mouse) (32)

Mmus\Lingo1

2 of 14

Yes

Mmus\Lingo2

2 of 14

Yes

Mmus\Chadl

1 of 14

Mmus\Cpn2

1 of 14

Mmus\Flrt3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Slit2

1 of 14

Mmus\Tril

1 of 14

Xenopus tropicalis (Western clawed frog) (58)

Xtro\lingo1

2 of 13

Yes

Xtro\lingo3

2 of 13

Yes

Xtro\lingo4

2 of 13

Yes

Xtro\amigo1

1 of 13

Yes

Xtro\chadl

1 of 13

Xtro\elfn1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\slitrk3

1 of 13

Yes

Xtro\slitrk6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (43)

Drer\lingo1a

2 of 14

Yes

Drer\lingo1b

2 of 14

Yes

Drer\lingo2b

2 of 14

Yes

Drer\lingo3a

2 of 14

Yes

Drer\lingo4a

2 of 14

Yes

Drer\lingo4b

2 of 14

Yes

Drer\LOC100151059

2 of 14

Yes

Drer\lrrn3a

2 of 14

Yes

Drer\si:ch211-237i5.4

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\lum

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-170a17.1

1 of 14

Drer\si:ch211-180f4.1

1 of 14

Drer\si:dkey-1j5.4

1 of 14

Drer\si:dkey-182i3.11

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (19)

Cele\iglr-2

4 of 14

Yes

Cele\lron-6

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (74)

Agam\AgaP_AGAP008611

10 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP004016

1 of 12

Yes

Agam\AgaP_AGAP004832

1 of 12

Agam\AgaP_AGAP005273

1 of 12

Agam\AgaP_AGAP005496

1 of 12

Yes

Agam\AgaP_AGAP005693

1 of 12

Agam\AgaP_AGAP006183

1 of 12

Agam\AgaP_AGAP006327

1 of 12

Yes

Agam\AgaP_AGAP006643

1 of 12

Agam\AgaP_AGAP006645

1 of 12

Agam\AgaP_AGAP007034

1 of 12

Yes

Agam\AgaP_AGAP007037

1 of 12

Agam\AgaP_AGAP007039

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP007456

1 of 12

Agam\AgaP_AGAP007457

1 of 12

Yes

Agam\AgaP_AGAP007464

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (8)

Atha\AT2G33170

1 of 13

Yes

Atha\AT3G15410

1 of 13

Yes

Atha\AT4G08850

1 of 13

Yes

Atha\AT5G63930

1 of 13

Yes

Atha\GSO2

1 of 13

Yes

Atha\HSL1

1 of 13

Yes

Atha\RLP12

1 of 13

Yes

Atha\RLP52

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG16974. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (56)

CG7896

3 of 13

kek6

3 of 13

rdo

3 of 13

18w

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

chp

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Lrt

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

trn

2 of 13

2mit

1 of 13

alrm

1 of 13

atk

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Con

1 of 13

conv

1 of 13

dtr

1 of 13

Fili

1 of 13

Gp150

1 of 13

haf

1 of 13

hfw

1 of 13

Lapsyn

1 of 13

lbk

1 of 13

Lgr4

1 of 13

ltl

1 of 13

Pxn

1 of 13

sli

1 of 13

swi2

1 of 13

Tehao

1 of 13

Toll-4

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

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Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CG16974 - osk

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Hurd et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0032479

MIST (protein-protein) - An integrated Molecular Interaction Database

34713

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Platelet degranulation

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-47

Cytogenetic map

34A8-34A8

Sequence location

2L:13,183,849..13,191,979 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34A8-34A8

Limits computationally determined from genome sequence between P{lacW}l(2)k11328^k11328&P{lacW}l(2)k10105^k10105 and P{EP}EP850&P{lacW}l(2)k05911^k05911

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-47

(FlyBase, 2016)

2-43.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

63775

w¹¹¹⁸; PBac{IT.GAL4}CG16974^0771-G4/CyO

15516

w¹¹¹⁸; P{EPgy2}CG16974^EY01543/CyO, P{sevRas1.V12}FK1

42590

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02422}attP40

92225

y¹ w^*; TI{CRIMIC.TG4.0}CG16974^{CR02358-TG4.0}/SM6a

NIG-Fly

M2L-2417

y¹ w¹¹¹⁸; CG16974^SK1 P{neoFRT}40A/CyO-Tb

M2L-2418

y¹ w¹¹¹⁸; CG16974^SK2 P{neoFRT}40A/CyO-Tb

HMS02422

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02422}attP40/CyO

2LG-1927

y² VhaAC39-1^cho-1 v¹; P{U6-CG16974.NIG.sgRNA}attP40/CyO

VDRC

v100366

P{KK106075}VIE-260B

v7993

w¹¹¹⁸; P{GD2507}v7993

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (65)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT01907

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0032479

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0032479

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG16974

(Duan et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Pang et al., 2021, Gene Disruption Project members, 2018-, Ulian-Benitez et al., 2017, Clandinin and Owens, 2016-, Hurd et al., 2016, Ozkan et al., 2013, Rodriguez et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Hayden and Bosco, 2008, Sepp et al., 2008)

CT35580

(Hynes and Zhao, 2000, Hynes and Zhao, 2000)

Dromel_CG16974_FBtr0080489_mORF

(Hayden and Bosco, 2008)

Name Synonyms

kekkon-like

(Hynes and Zhao, 2000, Hynes and Zhao, 2000)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34713

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VK28

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VK28

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0032479

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34713/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0032479

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0032479

FlyMine - An integrated database for Drosophila genomics

FBgn0032479

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG16974

MARRVEL_MODEL - MARRVEL (model organism gene)

34713

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0032479

DroID - A comprehensive database of gene and protein interactions.

FBgn0032479

DRSC - Results frm RNAi screens

FBgn0032479

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG16974_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032479

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0032479

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16974

Flygut - An atlas of the Drosophila adult midgut

FBgn0032479

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0032479

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008146

MIST (protein-protein) - An integrated Molecular Interaction Database

34713

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Platelet degranulation

References (40)

The following external sites may use different assemblies or annotations than FlyBase.

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