R3D1, TRBP, R3D1-L, R3D1-S
a component of a functional pre-miRNA processing complex - stimulates and directs pre-microRNA processing activity - a Dicer-1 partner that enhances miRNA processing from hairpins with unstable structures at the dicing site
Gene model reviewed during 5.51
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\loqs using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\loqs in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: loqs CG6866
The loqs-PD isoform is capable of associating with the Dcr-2 protein, but not with the Dcr-1 protein. The loqs-PB and loqs-PA isoforms can associate with the Dcr-1 protein, and also to some extent with Dcr-2 protein.
The loqs-PB isoform, and to a lesser extent the loqs-PA isoform, is capable of associating with the Dcr-1 protein. The loqs-PD isoform is capable of associating with the Dcr-2 protein, but not with the Dcr-1 protein.
loqs is not required for repeat-associated small interfering RNA (rasiRNA) production
loqs is required together with Dcr-1 for normal pre-miRNA processing. loqs is required for the normal silencing of the endogenous Ste locus in the testis and appears to be required for maintenance of the germ-line stem cells in the ovary.
loqs protein alone is not capable of converting pre-miRNAs into mature miRNAs. However, the loqs and Dcr-1 proteins form a complex that converts pre-miRNAs into mature miRNAs, and the loqs protein stimulates and directs the specific pre-miRNA processing activity of Dcr-1 protein.