Gene Dmel\CG9293

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General Information

Symbol

Dmel\CG9293

Species

D. melanogaster

Name

Annotation symbol

CG9293

Feature type

protein_coding_gene

FlyBase ID

FBgn0032516

Gene Model Status

Current

Stock availability

6 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

34B9-34B9

Sequence location

2L:13,385,848..13,387,312 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG9293 (FBgn0032516). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding. The biological processes in which it is involved are not known. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Inhibitor of growth protein, N-terminal; Zinc finger, FYVE/PHD-type; Zinc finger, PHD-finger; Zinc finger, PHD-type; Zinc finger, PHD-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, adult ovary, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1625566_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG9293. Gene sequence location is 2L:13385848..13387299.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34B9-34B9

Limits computationally determined from genome sequence between P{lacW}l(2)k00302^k00302 and P{PZ}kuz⁰³⁷⁸²&P{lacW}kuz^k14817

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG9293 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.51

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG9293-RA

FBtr0080525

NM_135803

1044

285

CG9293-RB

FBtr0080526

NM_165042

1002

271

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG9293-PA

FBpp0080103

32.1

285

8.71

NP_609647

AAF53297

CG9293-PB

FBpp0080104

30.5

271

8.38

NP_723814

AAN10835

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Zinc finger, PHD-type (IPR001965)

Zinc finger, FYVE/PHD-type (IPR011011)

Zinc finger, PHD-type, conserved site (IPR019786)

Zinc finger, PHD-finger (IPR019787)

Inhibitor of growth protein, N-terminal (IPR024610)

Zinc finger, RING/FYVE/PHD-type (IPR013083)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

Comment:reported as ventral nerve cord anlage

embryonic stage 9 -- 10

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

organism | faint & ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

organism | faint & ubiquitous

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, adult ovary, adult male reproductive system.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		139.2
Larval Midgut		56.5
Larval Hindgut		62.2
Larval Malpighian Tubules		159.5
Larval Fat Body		181.1
Larval Salivary Gland		177.1
Larval Trachea		96.425
Larval Carcass		70.775
Adult Head		79.2
Adult Eye		106.225
Adult Brain		130.9
Adult Thoracic-Abdominal Ganglion		111.2
Adult Crop		100.4
Adult Midgut		72.2
Adult Hindgut		78
Adult Malpighian Tubules		133.8
Adult Fat Body		71.3
Adult Salivary Gland		132.3
Adult Heart		77.35
Adult VirginFemale Spermatheca		94.6
Adult InseminatedFemale Spermatheca		90.7
Adult Ovary		246.9
Adult Testis		266.2
Adult Male Accessory Gland		153.8
Adult Carcass		69.6
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		139.2
Larval Midgut		56.5
Larval Hindgut		62.2
Larval Malpighian Tubules		159.5
Larval Fat Body		181.1
Larval Salivary Gland		177.1
Larval Trachea		96.425
Larval Carcass		70.775
Adult Head		79.2
Adult Eye		106.225
Adult Brain		130.9
Adult Thoracic-Abdominal Ganglion		111.2
Adult Crop		100.4
Adult Midgut		72.2
Adult Hindgut		78
Adult Malpighian Tubules		133.8
Adult Fat Body		71.3
Adult Salivary Gland		132.3
Adult Heart		77.35
Adult VirginFemale Spermatheca		94.6
Adult InseminatedFemale Spermatheca		90.7
Adult Ovary		246.9
Adult Testis		266.2
Adult Male Accessory Gland		153.8
Adult Carcass		69.6
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		139.2
Larval Midgut		56.5
Larval Hindgut		62.2
Larval Malpighian Tubules		159.5
Larval Fat Body		181.1
Larval Salivary Gland		177.1
Larval Trachea		96.425
Larval Carcass		70.775
Adult Head		79.2
Adult Eye		106.225
Adult Brain		130.9
Adult Thoracic-Abdominal Ganglion		111.2
Adult Crop		100.4
Adult Midgut		72.2
Adult Hindgut		78
Adult Malpighian Tubules		133.8
Adult Fat Body		71.3
Adult Salivary Gland		132.3
Adult Heart		77.35
Adult VirginFemale Spermatheca		94.6
Adult InseminatedFemale Spermatheca		90.7
Adult Ovary		246.9
Adult Testis		266.2
Adult Male Accessory Gland		153.8
Adult Carcass		69.6
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		139.2
Larval Midgut		56.5
Larval Hindgut		62.2
Larval Malpighian Tubules		159.5
Larval Fat Body		181.1
Larval Salivary Gland		177.1
Larval Trachea		96.425
Larval Carcass		70.775
Adult Head		79.2
Adult Eye		106.225
Adult Brain		130.9
Adult Thoracic-Abdominal Ganglion		111.2
Adult Crop		100.4
Adult Midgut		72.2
Adult Hindgut		78
Adult Malpighian Tubules		133.8
Adult Fat Body		71.3
Adult Salivary Gland		132.3
Adult Heart		77.35
Adult VirginFemale Spermatheca		94.6
Adult InseminatedFemale Spermatheca		90.7
Adult Ovary		246.9
Adult Testis		266.2
Adult Male Accessory Gland		153.8
Adult Carcass		69.6
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		139.2
Larval Midgut		56.5
Larval Hindgut		62.2
Larval Malpighian Tubules		159.5
Larval Fat Body		181.1
Larval Salivary Gland		177.1
Larval Trachea		96.425
Larval Carcass		70.775
Adult Head		79.2
Adult Eye		106.225
Adult Brain		130.9
Adult Thoracic-Abdominal Ganglion		111.2
Adult Crop		100.4
Adult Midgut		72.2
Adult Hindgut		78
Adult Malpighian Tubules		133.8
Adult Fat Body		71.3
Adult Salivary Gland		132.3
Adult Heart		77.35
Adult VirginFemale Spermatheca		94.6
Adult InseminatedFemale Spermatheca		90.7
Adult Ovary		246.9
Adult Testis		266.2
Adult Male Accessory Gland		153.8
Adult Carcass		69.6
Expression Level Scale		None Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		139.2
Larval Midgut		56.5
Larval Hindgut		62.2
Larval Malpighian Tubules		159.5
Larval Fat Body		181.1
Larval Salivary Gland		177.1
Larval Trachea		96.425
Larval Carcass		70.775
Adult Head		79.2
Adult Eye		106.225
Adult Brain		130.9
Adult Thoracic-Abdominal Ganglion		111.2
Adult Crop		100.4
Adult Midgut		72.2
Adult Hindgut		78
Adult Malpighian Tubules		133.8
Adult Fat Body		71.3
Adult Salivary Gland		132.3
Adult Heart		77.35
Adult VirginFemale Spermatheca		94.6
Adult InseminatedFemale Spermatheca		90.7
Adult Ovary		246.9
Adult Testis		266.2
Adult Male Accessory Gland		153.8
Adult Carcass		69.6
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		139.2
Larval Midgut		56.5
Larval Hindgut		62.2
Larval Malpighian Tubules		159.5
Larval Fat Body		181.1
Larval Salivary Gland		177.1
Larval Trachea		96.425
Larval Carcass		70.775
Adult Head		79.2
Adult Eye		106.225
Adult Brain		130.9
Adult Thoracic-Abdominal Ganglion		111.2
Adult Crop		100.4
Adult Midgut		72.2
Adult Hindgut		78
Adult Malpighian Tubules		133.8
Adult Fat Body		71.3
Adult Salivary Gland		132.3
Adult Heart		77.35
Adult VirginFemale Spermatheca		94.6
Adult InseminatedFemale Spermatheca		90.7
Adult Ovary		246.9
Adult Testis		266.2
Adult Male Accessory Gland		153.8
Adult Carcass		69.6
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		139.2
Larval Midgut		56.5
Larval Hindgut		62.2
Larval Malpighian Tubules		159.5
Larval Fat Body		181.1
Larval Salivary Gland		177.1
Larval Trachea		96.425
Larval Carcass		70.775
Adult Head		79.2
Adult Eye		106.225
Adult Brain		130.9
Adult Thoracic-Abdominal Ganglion		111.2
Adult Crop		100.4
Adult Midgut		72.2
Adult Hindgut		78
Adult Malpighian Tubules		133.8
Adult Fat Body		71.3
Adult Salivary Gland		132.3
Adult Heart		77.35
Adult VirginFemale Spermatheca		94.6
Adult InseminatedFemale Spermatheca		90.7
Adult Ovary		246.9
Adult Testis		266.2
Adult Male Accessory Gland		153.8
Adult Carcass		69.6
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	79.2
NA	Eye	106.225
NA	Brain	130.9
139.2	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	111.2
NA	Crop	100.4
56.5	Midgut	72.2
62.2	Hindgut	78
159.5	Malpighian Tubules	133.8
181.1	Fat Body	no informative data
177.1	Salivary Gland	132.3
NA	Heart	77.35
96.425	Trachea	NA
NA	VirginFemale Spermatheca	no informative data
NA	InseminatedFemale Spermatheca	90.7
NA	Ovary	246.9
NA	Testis	266.2
NA	Male Accessory Gland	153.8
70.775	Carcass	no informative data

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		40
central nervous system, larvae L3		30
central nervous system, pupae P8		21
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		9
head, mated 1-day female		14
head, mated 4-day female		12
head, mated 20-day female		10
head, mated 1-day male		16
head, mated 4-day male		18
head, mated 20-day male		19
salivary gland, larvae L3 wandering		51
salivary gland, white prepupae		104
digestive system, larvae L3 wandering		34
digestive system, 1-day adult		13
digestive system, 4-day adult		12
digestive system, 20-day adult		10
fat body, larvae L3 wandering		10
fat body, white prepupae		28
fat body, pupae P8		37
carcass, larvae L3 wandering		27
carcass, 1-day adult		10
carcass, 4-day adult		16
carcass, 20-day adult		12
ovary, virgin 4-day female		40
ovary, mated 4-day female		54
testis, mated 4-day male		64
accessory gland, mated 4-day male		17
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(40)
central nervous system, larvae L3		(30)
central nervous system, pupae P8		21
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		9
head, mated 1-day female		14
head, mated 4-day female		12
head, mated 20-day female		10
head, mated 1-day male		16
head, mated 4-day male		18
head, mated 20-day male		19
salivary gland, larvae L3 wandering		(51)
salivary gland, white prepupae		(104)
digestive system, larvae L3 wandering		(34)
digestive system, 1-day adult		13
digestive system, 4-day adult		12
digestive system, 20-day adult		10
fat body, larvae L3 wandering		10
fat body, white prepupae		(28)
fat body, pupae P8		(37)
carcass, larvae L3 wandering		(27)
carcass, 1-day adult		10
carcass, 4-day adult		16
carcass, 20-day adult		12
ovary, virgin 4-day female		(40)
ovary, mated 4-day female		(54)
testis, mated 4-day male		(64)
accessory gland, mated 4-day male		17
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		40
central nervous system, larvae L3		30
central nervous system, pupae P8		21
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		9
head, mated 1-day female		14
head, mated 4-day female		12
head, mated 20-day female		10
head, mated 1-day male		16
head, mated 4-day male		18
head, mated 20-day male		19
salivary gland, larvae L3 wandering		51
salivary gland, white prepupae		104
digestive system, larvae L3 wandering		34
digestive system, 1-day adult		13
digestive system, 4-day adult		12
digestive system, 20-day adult		10
fat body, larvae L3 wandering		10
fat body, white prepupae		28
fat body, pupae P8		37
carcass, larvae L3 wandering		27
carcass, 1-day adult		10
carcass, 4-day adult		16
carcass, 20-day adult		12
ovary, virgin 4-day female		40
ovary, mated 4-day female		54
testis, mated 4-day male		64
accessory gland, mated 4-day male		17
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		40
central nervous system, larvae L3		30
central nervous system, pupae P8		21
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		9
head, mated 1-day female		14
head, mated 4-day female		12
head, mated 20-day female		10
head, mated 1-day male		16
head, mated 4-day male		18
head, mated 20-day male		19
salivary gland, larvae L3 wandering		51
salivary gland, white prepupae		104
digestive system, larvae L3 wandering		34
digestive system, 1-day adult		13
digestive system, 4-day adult		12
digestive system, 20-day adult		10
fat body, larvae L3 wandering		10
fat body, white prepupae		28
fat body, pupae P8		37
carcass, larvae L3 wandering		27
carcass, 1-day adult		10
carcass, 4-day adult		16
carcass, 20-day adult		12
ovary, virgin 4-day female		40
ovary, mated 4-day female		54
testis, mated 4-day male		64
accessory gland, mated 4-day male		17
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		40
central nervous system, larvae L3		30
central nervous system, pupae P8		21
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		9
head, mated 1-day female		14
head, mated 4-day female		12
head, mated 20-day female		10
head, mated 1-day male		16
head, mated 4-day male		18
head, mated 20-day male		19
salivary gland, larvae L3 wandering		51
salivary gland, white prepupae		104
digestive system, larvae L3 wandering		34
digestive system, 1-day adult		13
digestive system, 4-day adult		12
digestive system, 20-day adult		10
fat body, larvae L3 wandering		10
fat body, white prepupae		28
fat body, pupae P8		37
carcass, larvae L3 wandering		27
carcass, 1-day adult		10
carcass, 4-day adult		16
carcass, 20-day adult		12
ovary, virgin 4-day female		40
ovary, mated 4-day female		54
testis, mated 4-day male		64
accessory gland, mated 4-day male		17
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(40)
central nervous system, larvae L3		30
central nervous system, pupae P8		21
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		9
head, mated 1-day female		14
head, mated 4-day female		12
head, mated 20-day female		10
head, mated 1-day male		16
head, mated 4-day male		18
head, mated 20-day male		19
salivary gland, larvae L3 wandering		(51)
salivary gland, white prepupae		(104)
digestive system, larvae L3 wandering		(34)
digestive system, 1-day adult		13
digestive system, 4-day adult		12
digestive system, 20-day adult		10
fat body, larvae L3 wandering		10
fat body, white prepupae		28
fat body, pupae P8		(37)
carcass, larvae L3 wandering		27
carcass, 1-day adult		10
carcass, 4-day adult		16
carcass, 20-day adult		12
ovary, virgin 4-day female		(40)
ovary, mated 4-day female		(54)
testis, mated 4-day male		(64)
accessory gland, mated 4-day male		17
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		40
central nervous system, larvae L3		30
central nervous system, pupae P8		21
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		9
head, mated 1-day female		14
head, mated 4-day female		12
head, mated 20-day female		10
head, mated 1-day male		16
head, mated 4-day male		18
head, mated 20-day male		19
salivary gland, larvae L3 wandering		51
salivary gland, white prepupae		104
digestive system, larvae L3 wandering		34
digestive system, 1-day adult		13
digestive system, 4-day adult		12
digestive system, 20-day adult		10
fat body, larvae L3 wandering		10
fat body, white prepupae		28
fat body, pupae P8		37
carcass, larvae L3 wandering		27
carcass, 1-day adult		10
carcass, 4-day adult		16
carcass, 20-day adult		12
ovary, virgin 4-day female		40
ovary, mated 4-day female		54
testis, mated 4-day male		64
accessory gland, mated 4-day male		17
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		40
central nervous system, larvae L3		30
central nervous system, pupae P8		21
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		9
head, mated 1-day female		14
head, mated 4-day female		12
head, mated 20-day female		10
head, mated 1-day male		16
head, mated 4-day male		18
head, mated 20-day male		19
salivary gland, larvae L3 wandering		51
salivary gland, white prepupae		104
digestive system, larvae L3 wandering		34
digestive system, 1-day adult		13
digestive system, 4-day adult		12
digestive system, 20-day adult		10
fat body, larvae L3 wandering		10
fat body, white prepupae		28
fat body, pupae P8		37
carcass, larvae L3 wandering		27
carcass, 1-day adult		10
carcass, 4-day adult		16
carcass, 20-day adult		12
ovary, virgin 4-day female		40
ovary, mated 4-day female		54
testis, mated 4-day male		64
accessory gland, mated 4-day male		17
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		35
embryo 02-04hr		38
embryo 04-06hr		43
embryo 06-08hr		40
embryo 08-10hr		34
embryo 10-12hr		21
embryo 12-14hr		23
embryo 14-16hr		16
embryo 16-18hr		15
embryo 18-20hr		11
embryo 20-22hr		13
embryo 22-24hr		15
larva L1		7
larva L2		6
larva L3 12hr old		5
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		27
white prepupae new		30
white prepupae 12hr		33
white prepupae 24hr		32
pupae 2d postWPP		34
pupae 3d postWPP		17
pupae 4d postWPP		12
adult male 01day		18
adult male 05day		23
adult male 30day		20
adult female 01day		11
adult female 05day		21
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(35)
embryo 02-04hr		(38)
embryo 04-06hr		(43)
embryo 06-08hr		(40)
embryo 08-10hr		(34)
embryo 10-12hr		21
embryo 12-14hr		23
embryo 14-16hr		16
embryo 16-18hr		15
embryo 18-20hr		11
embryo 20-22hr		13
embryo 22-24hr		15
larva L1		7
larva L2		6
larva L3 12hr old		5
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		(27)
white prepupae new		(30)
white prepupae 12hr		(33)
white prepupae 24hr		(32)
pupae 2d postWPP		(34)
pupae 3d postWPP		17
pupae 4d postWPP		12
adult male 01day		18
adult male 05day		23
adult male 30day		20
adult female 01day		11
adult female 05day		21
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		35
embryo 02-04hr		38
embryo 04-06hr		43
embryo 06-08hr		40
embryo 08-10hr		34
embryo 10-12hr		21
embryo 12-14hr		23
embryo 14-16hr		16
embryo 16-18hr		15
embryo 18-20hr		11
embryo 20-22hr		13
embryo 22-24hr		15
larva L1		7
larva L2		6
larva L3 12hr old		5
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		27
white prepupae new		30
white prepupae 12hr		33
white prepupae 24hr		32
pupae 2d postWPP		34
pupae 3d postWPP		17
pupae 4d postWPP		12
adult male 01day		18
adult male 05day		23
adult male 30day		20
adult female 01day		11
adult female 05day		21
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		35
embryo 02-04hr		38
embryo 04-06hr		43
embryo 06-08hr		40
embryo 08-10hr		34
embryo 10-12hr		21
embryo 12-14hr		23
embryo 14-16hr		16
embryo 16-18hr		15
embryo 18-20hr		11
embryo 20-22hr		13
embryo 22-24hr		15
larva L1		7
larva L2		6
larva L3 12hr old		5
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		27
white prepupae new		30
white prepupae 12hr		33
white prepupae 24hr		32
pupae 2d postWPP		34
pupae 3d postWPP		17
pupae 4d postWPP		12
adult male 01day		18
adult male 05day		23
adult male 30day		20
adult female 01day		11
adult female 05day		21
adult female 30day		20
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		35
embryo 02-04hr		38
embryo 04-06hr		43
embryo 06-08hr		40
embryo 08-10hr		34
embryo 10-12hr		21
embryo 12-14hr		23
embryo 14-16hr		16
embryo 16-18hr		15
embryo 18-20hr		11
embryo 20-22hr		13
embryo 22-24hr		15
larva L1		7
larva L2		6
larva L3 12hr old		5
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		27
white prepupae new		30
white prepupae 12hr		33
white prepupae 24hr		32
pupae 2d postWPP		34
pupae 3d postWPP		17
pupae 4d postWPP		12
adult male 01day		18
adult male 05day		23
adult male 30day		20
adult female 01day		11
adult female 05day		21
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(35)
embryo 02-04hr		(38)
embryo 04-06hr		(43)
embryo 06-08hr		(40)
embryo 08-10hr		(34)
embryo 10-12hr		21
embryo 12-14hr		23
embryo 14-16hr		16
embryo 16-18hr		15
embryo 18-20hr		11
embryo 20-22hr		13
embryo 22-24hr		15
larva L1		7
larva L2		6
larva L3 12hr old		5
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		27
white prepupae new		30
white prepupae 12hr		(33)
white prepupae 24hr		32
pupae 2d postWPP		(34)
pupae 3d postWPP		17
pupae 4d postWPP		12
adult male 01day		18
adult male 05day		23
adult male 30day		20
adult female 01day		11
adult female 05day		21
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		35
embryo 02-04hr		38
embryo 04-06hr		43
embryo 06-08hr		40
embryo 08-10hr		34
embryo 10-12hr		21
embryo 12-14hr		23
embryo 14-16hr		16
embryo 16-18hr		15
embryo 18-20hr		11
embryo 20-22hr		13
embryo 22-24hr		15
larva L1		7
larva L2		6
larva L3 12hr old		5
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		27
white prepupae new		30
white prepupae 12hr		33
white prepupae 24hr		32
pupae 2d postWPP		34
pupae 3d postWPP		17
pupae 4d postWPP		12
adult male 01day		18
adult male 05day		23
adult male 30day		20
adult female 01day		11
adult female 05day		21
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		35
embryo 02-04hr		38
embryo 04-06hr		43
embryo 06-08hr		40
embryo 08-10hr		34
embryo 10-12hr		21
embryo 12-14hr		23
embryo 14-16hr		16
embryo 16-18hr		15
embryo 18-20hr		11
embryo 20-22hr		13
embryo 22-24hr		15
larva L1		7
larva L2		6
larva L3 12hr old		5
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		27
white prepupae new		30
white prepupae 12hr		33
white prepupae 24hr		32
pupae 2d postWPP		34
pupae 3d postWPP		17
pupae 4d postWPP		12
adult male 01day		18
adult male 05day		23
adult male 30day		20
adult female 01day		11
adult female 05day		21
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		40
Schneider line 2 Sg4		10
embryonic 1182-4H		26
embryonic GM2		15
embryonic Kc167		29
embryonic S1		76
embryonic S3		13
leg disc CME L1		23
wing disc CME-W2		16
wing disc ML-DmD8		11
wing disc ML-DmD9		41
wing disc ML-DmD16-c3		40
wing disc ML-DmD21		30
wing disc ML-DmD32		27
haltere disc ML-DmD17-c3		25
eye-antennal disc ML-DmD11		28
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		16
CNS ML-DmBG1-c1		39
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		10
ovary fGS/OSS		87
ovary OSC		57
ovary OSS		34
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(40)
Schneider line 2 Sg4		10
embryonic 1182-4H		26
embryonic GM2		15
embryonic Kc167		(29)
embryonic S1		(76)
embryonic S3		13
leg disc CME L1		23
wing disc CME-W2		16
wing disc ML-DmD8		11
wing disc ML-DmD9		(41)
wing disc ML-DmD16-c3		(40)
wing disc ML-DmD21		(30)
wing disc ML-DmD32		(27)
haltere disc ML-DmD17-c3		25
eye-antennal disc ML-DmD11		(28)
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		16
CNS ML-DmBG1-c1		(39)
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		10
ovary fGS/OSS		(87)
ovary OSC		(57)
ovary OSS		(34)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		40
Schneider line 2 Sg4		10
embryonic 1182-4H		26
embryonic GM2		15
embryonic Kc167		29
embryonic S1		76
embryonic S3		13
leg disc CME L1		23
wing disc CME-W2		16
wing disc ML-DmD8		11
wing disc ML-DmD9		41
wing disc ML-DmD16-c3		40
wing disc ML-DmD21		30
wing disc ML-DmD32		27
haltere disc ML-DmD17-c3		25
eye-antennal disc ML-DmD11		28
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		16
CNS ML-DmBG1-c1		39
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		10
ovary fGS/OSS		87
ovary OSC		57
ovary OSS		34
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		40
Schneider line 2 Sg4		10
embryonic 1182-4H		26
embryonic GM2		15
embryonic Kc167		29
embryonic S1		76
embryonic S3		13
leg disc CME L1		23
wing disc CME-W2		16
wing disc ML-DmD8		11
wing disc ML-DmD9		41
wing disc ML-DmD16-c3		40
wing disc ML-DmD21		30
wing disc ML-DmD32		27
haltere disc ML-DmD17-c3		25
eye-antennal disc ML-DmD11		28
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		16
CNS ML-DmBG1-c1		39
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		10
ovary fGS/OSS		87
ovary OSC		57
ovary OSS		34
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		40
Schneider line 2 Sg4		10
embryonic 1182-4H		26
embryonic GM2		15
embryonic Kc167		29
embryonic S1		76
embryonic S3		13
leg disc CME L1		23
wing disc CME-W2		16
wing disc ML-DmD8		11
wing disc ML-DmD9		41
wing disc ML-DmD16-c3		40
wing disc ML-DmD21		30
wing disc ML-DmD32		27
haltere disc ML-DmD17-c3		25
eye-antennal disc ML-DmD11		28
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		16
CNS ML-DmBG1-c1		39
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		10
ovary fGS/OSS		87
ovary OSC		57
ovary OSS		34
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(40)
Schneider line 2 Sg4		10
embryonic 1182-4H		26
embryonic GM2		15
embryonic Kc167		29
embryonic S1		(76)
embryonic S3		13
leg disc CME L1		23
wing disc CME-W2		16
wing disc ML-DmD8		11
wing disc ML-DmD9		(41)
wing disc ML-DmD16-c3		(40)
wing disc ML-DmD21		30
wing disc ML-DmD32		27
haltere disc ML-DmD17-c3		25
eye-antennal disc ML-DmD11		28
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		16
CNS ML-DmBG1-c1		(39)
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		10
ovary fGS/OSS		(87)
ovary OSC		(57)
ovary OSS		(34)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		40
Schneider line 2 Sg4		10
embryonic 1182-4H		26
embryonic GM2		15
embryonic Kc167		29
embryonic S1		76
embryonic S3		13
leg disc CME L1		23
wing disc CME-W2		16
wing disc ML-DmD8		11
wing disc ML-DmD9		41
wing disc ML-DmD16-c3		40
wing disc ML-DmD21		30
wing disc ML-DmD32		27
haltere disc ML-DmD17-c3		25
eye-antennal disc ML-DmD11		28
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		16
CNS ML-DmBG1-c1		39
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		10
ovary fGS/OSS		87
ovary OSC		57
ovary OSS		34
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		40
Schneider line 2 Sg4		10
embryonic 1182-4H		26
embryonic GM2		15
embryonic Kc167		29
embryonic S1		76
embryonic S3		13
leg disc CME L1		23
wing disc CME-W2		16
wing disc ML-DmD8		11
wing disc ML-DmD9		41
wing disc ML-DmD16-c3		40
wing disc ML-DmD21		30
wing disc ML-DmD32		27
haltere disc ML-DmD17-c3		25
eye-antennal disc ML-DmD11		28
antennal disc ML-DmD20-c5		20
mixed discs ML-DmD4-c1		16
CNS ML-DmBG1-c1		39
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		10
ovary fGS/OSS		87
ovary OSC		57
ovary OSS		34
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		37
cold shock, 4-day adult		34
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		20
Cadmium 50 mM 48 hrs, 4-day adult		17
Cadmium 100 mM 48 hrs, 4-day adult		38
Copper 0.5 mM 12 hrs, larvae L3		20
Copper 15 mM 48 hrs, 4-day adult		34
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		39
Ethanol 5% 3 hrs, larvae L3		11
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		35
Caffeine 25 mg/ml 48 hrs, 4-day adult		35
Paraquat 5 mM 48 hrs, 4-day adult		32
Paraquat 10 mM 48 hrs, 4-day adult		28
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(37)
cold shock, 4-day adult		(34)
heat shock, 4-day adult		(28)
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		20
Cadmium 50 mM 48 hrs, 4-day adult		17
Cadmium 100 mM 48 hrs, 4-day adult		(38)
Copper 0.5 mM 12 hrs, larvae L3		20
Copper 15 mM 48 hrs, 4-day adult		(34)
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		(27)
Ethanol 2.5% 3 hrs, larvae L3		(39)
Ethanol 5% 3 hrs, larvae L3		11
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(35)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(35)
Paraquat 5 mM 48 hrs, 4-day adult		(32)
Paraquat 10 mM 48 hrs, 4-day adult		(28)
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		37
cold shock, 4-day adult		34
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		20
Cadmium 50 mM 48 hrs, 4-day adult		17
Cadmium 100 mM 48 hrs, 4-day adult		38
Copper 0.5 mM 12 hrs, larvae L3		20
Copper 15 mM 48 hrs, 4-day adult		34
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		39
Ethanol 5% 3 hrs, larvae L3		11
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		35
Caffeine 25 mg/ml 48 hrs, 4-day adult		35
Paraquat 5 mM 48 hrs, 4-day adult		32
Paraquat 10 mM 48 hrs, 4-day adult		28
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		37
cold shock, 4-day adult		34
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		20
Cadmium 50 mM 48 hrs, 4-day adult		17
Cadmium 100 mM 48 hrs, 4-day adult		38
Copper 0.5 mM 12 hrs, larvae L3		20
Copper 15 mM 48 hrs, 4-day adult		34
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		39
Ethanol 5% 3 hrs, larvae L3		11
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		35
Caffeine 25 mg/ml 48 hrs, 4-day adult		35
Paraquat 5 mM 48 hrs, 4-day adult		32
Paraquat 10 mM 48 hrs, 4-day adult		28
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		37
cold shock, 4-day adult		34
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		20
Cadmium 50 mM 48 hrs, 4-day adult		17
Cadmium 100 mM 48 hrs, 4-day adult		38
Copper 0.5 mM 12 hrs, larvae L3		20
Copper 15 mM 48 hrs, 4-day adult		34
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		39
Ethanol 5% 3 hrs, larvae L3		11
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		35
Caffeine 25 mg/ml 48 hrs, 4-day adult		35
Paraquat 5 mM 48 hrs, 4-day adult		32
Paraquat 10 mM 48 hrs, 4-day adult		28
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(37)
cold shock, 4-day adult		(34)
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		20
Cadmium 50 mM 48 hrs, 4-day adult		17
Cadmium 100 mM 48 hrs, 4-day adult		(38)
Copper 0.5 mM 12 hrs, larvae L3		20
Copper 15 mM 48 hrs, 4-day adult		(34)
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		(39)
Ethanol 5% 3 hrs, larvae L3		11
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(35)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(35)
Paraquat 5 mM 48 hrs, 4-day adult		32
Paraquat 10 mM 48 hrs, 4-day adult		28
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		37
cold shock, 4-day adult		34
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		20
Cadmium 50 mM 48 hrs, 4-day adult		17
Cadmium 100 mM 48 hrs, 4-day adult		38
Copper 0.5 mM 12 hrs, larvae L3		20
Copper 15 mM 48 hrs, 4-day adult		34
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		39
Ethanol 5% 3 hrs, larvae L3		11
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		35
Caffeine 25 mg/ml 48 hrs, 4-day adult		35
Paraquat 5 mM 48 hrs, 4-day adult		32
Paraquat 10 mM 48 hrs, 4-day adult		28
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		37
cold shock, 4-day adult		34
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		8
Cadmium 50 mM 12 hrs, larvae L3		20
Cadmium 50 mM 48 hrs, 4-day adult		17
Cadmium 100 mM 48 hrs, 4-day adult		38
Copper 0.5 mM 12 hrs, larvae L3		20
Copper 15 mM 48 hrs, 4-day adult		34
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		39
Ethanol 5% 3 hrs, larvae L3		11
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		35
Caffeine 25 mg/ml 48 hrs, 4-day adult		35
Paraquat 5 mM 48 hrs, 4-day adult		32
Paraquat 10 mM 48 hrs, 4-day adult		28
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

SD11456

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0032516

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG9293-RB

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

CG9293^EY13364

Sterility

Allele

fertile

CG9293^EY13364

Phenotype manifest in

Allele

Classical Alleles ( 3 )

For All Classical Alleles Show

Allele of CG9293	Mutagen	Stocks	Known lesion
CG9293^f03884	piggyBac transposase	3	--
CG9293^c07143		1	--
CG9293^EY13364	P-element activity	1	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG9293	Mutagen	Stocks	Known lesion
CG9293^KK108992	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG9293^GD14175	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
CG9293^{Scer\UAS.T:MS2\MCP.BS}	in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(2L)loqs^del

(Ghildiyal et al., 2006)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD14175}

P{KK108992}

P{UAS-CG9293.MS2bs}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EPgy2}CG9293^EY13364

miscellaneous insertions

PBac{PB}CG9293^c07143

PBac{WH}CG9293^f03884

Gene Ontology: Function, Process & Cellular Component ( 1 unique term )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 1 term )

Molecular Function

CV term

Evidence

References

zinc ion binding

inferred from electronic annotation with InterPro:IPR001965

(FlyBase Curators et al., 2004-)

Biological Process ( 0 terms)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG9293 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

60787

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0032516

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

34752

Orthologs

OrthoDB Orthologs (65) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6MSDJK

Dipteran inclusive ortholog search

EOG612MFG

Insect inclusive ortholog search

EOG6DZ0RG

Arthropod inclusive ortholog search

EOG6NCJVW

Metazoa inclusive ortholog search

EOG6FFRW2

Orthologs in Drosophila Species (EOG6MSDJK)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA22529

Drosophila pseudoobscura pseudoobscura

Dpse\GA21675

Drosophila persimilis

Dper\GL25709

Drosophila willistoni

Dwil\GK15283

Drosophila virilis

Dvir\GJ18259

Drosophila mojavensis

Dmoj\GI14043

Drosophila grimshawi

Dgri\GH13451

Orthologs in non-Drosophila Dipterans (EOG612MFG)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL004983

Anopheles gambiae

Malaria mosquito

Agam\AGAP009992

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006425

Orthologs in non-Dipteran Insects (EOG6DZ0RG)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\LOC551029

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG013829

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH19764

Atta cephalotes

Leafcutter ant

Acep\ACEP15447

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO13077

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL21620

Linepithema humile

Argentine ant

Lhum\LH15205

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB18141

Solenopsis invicta

Red fire ant

Sinv\SINV13892

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003380

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002366

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007917

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009726

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI40524

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007490

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI084667

Bombyx mori

Silkmoth

Bmor\BGIBMGA007480

Pediculus humanus

Human body louse

Phum\PHUM396770

Tribolium castaneum

Red flour beetle

Tcas\TC013703

Orthologs in non-Insect Arthropods (EOG6NCJVW)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\JGI_V11_308315

Ixodes scapularis

Deer tick

Isca\ISCW006958

Orthologs in non-Arthropod Metazoa (EOG6FFRW2)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\lsy-13

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_028848gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_006666gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_003871gn

Danio rerio

Zebrafish

Drer\ing4

Danio rerio

Zebrafish

Drer\ing2

Danio rerio

Zebrafish

Drer\ing1

Danio rerio

Zebrafish

Drer\ing5a

Danio rerio

Zebrafish

Drer\ing5b

Xenopus tropicalis

Western clawed frog

Xtro\ing5

Xenopus tropicalis

Western clawed frog

Xtro\ing1

Xenopus tropicalis

Western clawed frog

Xtro\ing2

Gallus gallus

Domestic chicken

Ggal\ING5

Gallus gallus

Domestic chicken

Ggal\ING2

Gallus gallus

Domestic chicken

Ggal\ING1

Gallus gallus

Domestic chicken

Ggal\ING4

Mus musculus

House mouse

Mmus\Ing2

Mus musculus

House mouse

Mmus\Ing5

Mus musculus

House mouse

Mmus\Ing4

Mus musculus

House mouse

Mmus\Ing1

Rattus norvegicus

Norway rat

Rnor\Ing5

Rattus norvegicus

Norway rat

Rnor\Ing1

Rattus norvegicus

Norway rat

Rnor\Ing2

Rattus norvegicus

Norway rat

Rnor\Ing4

Homo sapiens

Human

Hsap\ING2

Homo sapiens

Human

Hsap\ING5

Homo sapiens

Human

Hsap\ENSG00000153487

Homo sapiens

Human

Hsap\ING4

Human Orthologs (4)

Gene

OMIM

HGNC

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA21675

Drosophila persimilis

Dper\GL25709

Drosophila willistoni

Dwil\GK15283

Drosophila virilis

Dvir\GJ18259

Drosophila mojavensis

Dmoj\GI14043

Drosophila grimshawi

Dgri\GH13451

Stocks & Reagents

Stocks Listed in FlyBase ( 6 )

Bloomington

18705

w¹¹¹⁸; PBac{WH}CG9293^f03884/CyO

20873

y¹ w^67c23; P{EPgy2}CG9293^EY13364

Harvard

PBac{PB}CG9293^c07143

PBac{WH}CG9293^f03884

Kyoto

114654

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; PBac{WH}CG9293^f03884 P{neoFRT}40A/CyO y⁺

VDRC

v102002

P{KK108992}VIE-260B

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 35 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0032516

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

34752

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

34752

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Zinc finger, PHD-type (IPR001965)

Zinc finger, FYVE/PHD-type (IPR011011)

Zinc finger, PHD-type, conserved site (IPR019786)

Zinc finger, PHD-finger (IPR019787)

Inhibitor of growth protein, N-terminal (IPR024610)

Zinc finger, RING/FYVE/PHD-type (IPR013083)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

SD11456

Linkouts

BioGRID - A database of protein and genetic interactions

•

60787

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0032516

DRSC - Results from RNAi screens.

•

FBgn0032516

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0032516

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG9293-RB

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0032516

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

34752

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

34752

modMine - Data generated by the modENCODE project.

•

FBgn0032516

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG9293

(Bienz, 2006, Estes et al., 2008, Zarnescu et al., 2005, Keleman et al., 2009.8.5, Kim and Orr-Weaver, 2011)

Name Synonym

Secondary FlyBase IDs

References ( 21 )

Generate a list of

All references relating to this gene ( 21 )

List References by type

Recent research papers ( 1 )

Kim and Orr-Weaver, 2011, Proc. Natl. Acad. Sci. U.S.A. 108(40): 16681--16686: Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins. [FBrf0216239]

Show all research papers ...

Recent reviews (0)

All reviews listed in FlyBase were published before 2011

Show reviews ...