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Gene Dmel\Tpr2

General Information
Symbol	Dmel\Tpr2	Species	D. melanogaster
Name	Tetratricopeptide repeat protein 2	Annotation symbol	CG4599
Feature type	protein_coding_gene	FlyBase ID	FBgn0032586
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	dTPR2
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	36A2-36A2	Sequence location	2L:16,491,540..16,507,621 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Tetratricopeptide repeat protein 2 is referred to in FlyBase by the symbol Dmel\Tpr2 (CG4599, FBgn0032586). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: unfolded protein binding. Based on sequence similarity, it is predicted to be involved in the biological process: protein folding. 13 alleles are reported. The phenotypes of these alleles are annotated with: eye; wing. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: DnaJ domain; DnaJ domain, conserved site; Tetratricopeptide TPR-1; Tetratricopeptide TPR2; Tetratricopeptide repeat; Tetratricopeptide repeat-containing domain; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635861_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Tpr2. Gene sequence location is 2L:16491540..16507621.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles Tpr2[EB7-1A]
FB2013_02	Controlled Vocabulary Terms protein folding cellular_component unfolded protein binding
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36A2-36A2   Limits computationally determined from genome sequence between P{PZ}dacP and P{EP}grpEP921&P{lacW}l(2)k13905k13905
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tpr2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tpr2-RA FBtr0080866  NM_078860   2116   508 Tpr2-RB FBtr0080867  NM_165164   2103   464 Tpr2-RC FBtr0333486  NM_001273571   1877   478 Tpr2-RD FBtr0333487  NM_001273572   2503   508 Tpr2-RE FBtr0333488  NM_001273573   2373   464
Additional Transcript Data & Comments
Reported size (kB)	2.239 (longest cDNA) (Kazemi-Esfarjani and Benzer, 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tpr2-PA   FBpp0080423   58.0   508   6.44     NP_523584   AAF53540 Tpr2-PB   FBpp0080424   53.2   464   8.53     NP_723974   AAN10946 Tpr2-PC   FBpp0305670   54.9   478   8.53     NP_001260500   AGB93035 Tpr2-PD   FBpp0305671   58.0   508   6.44     NP_001260501   AGB93036 Tpr2-PE   FBpp0305672   53.2   464   8.53     NP_001260502   AGB93037
Additional Polypeptide Data & Comments
Reported size (kDa)	508 (aa); 58 (kD predicted) (Kazemi-Esfarjani and Benzer, 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DnaJ domain, conserved site (IPR018253) DnaJ domain (IPR001623) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing domain (IPR013026) Tetratricopeptide repeat (IPR019734) Tetratricopeptide TPR-1 (IPR001440) Tetratricopeptide TPR2 (IPR013105)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201154   AA201429   AA201527   AA202799   AA391402   AA392620   AA438290   AA438619   AA439655   AA440018   AA441093   AA541065   AA695280   AA735495   AA820520   AA820977   AA941028   AA941597   AA949900   AA950277   AA950779   AA951077   AA951083   AA952015   AA978757   AE014134 AAF53540   AE014134 AAN10946   AF199022 AAF43627   AE014134 AGB93035   AE014134 AGB93036   AE014134 AGB93037   AI110008   AI110009   AI455565   AI455870   AI456052   AI456556   AI457049   AI514849   AI516274   AI516760   AI516974   AI519786   AI544064   AI546378   AI945073   AI945627   AW941168   BF486476   BF488070   BF492315   BF495442   BF497941   BF498493   BF498619   BF500030   BF501002   BF502596   BF504281   BF504555   BF505427   BG632486   BH901016   BI162854   BI163536   BI164940   BI165222   BI165296   BI166851   BI168380   BI169298   BI169940   BI170332   BI170388   BI170698   BI213607   BI213773   BI216025   BI216499   BI228103   BI228704   BI231882   BI232097   BI232594   BI233175   BI234012   BI234203   BI234692   BI237196   BI238248   BI239072   BI239793   BI239808   BI242932   BI362495   BI363649   BI363692   BI367007   BI367302   BI372212   BI374601   BI374723   BI374863   BI374908   BI375238   BI484310   BI484929   BI485767   BI486386   BI578045   BI579145   BI580599   BI592209   BI610262   BI619638   BI623706   BI624642   BI632264   BP543053   BT001725 AAN71480   BT011142   BT100099   CK657156   CK659714   CO153751   CO178240   CO188763   CO191437   CO262502   CO269643   CO273455   CO280199   CO284862   CO285296   CO286580   CO291396   CO292074   CO296923   CO302639   CO303839   CO306982   CO311602   CO315554   CO316924   CO319393   CO319816   CO319861   CO322269   CO326231   CO335617   CZ471179   CZ471186   CZ489597   CZ489828   CZ489829   EC067065   EC067101   EC076261   EC080279   EC080688   EC090832   EC091163   EC196659   EC200127   EC200565   EC201489   EC203525   EC209353   EC212409   EC213159   EC222207   EC227294   EC230921   EC230922   EC231727   EC234847   EC235894   EC238386   EC241119   EC247094   EC248180   EC253067   EC264575   EC265911   ES695819   ES695821   EV579818   GH747807   GH749172   GH751676   GH751963   GH753214   GH754212   GH756006   GH758277   GH758661   GH771170   GH772591   GH774780   GH778742   GH779146   GH781065   GH781858   GH787070   GH791039   GH792919   GH793404   GH794497   GH796305   GH796867   GH797017   GH797047   GH797608   GH798339   GH803183   GH807058   GH807543   GH808572   GH809541   GH810436   GH813585   GH816200   GH817867   GH818676   GH828784   GH832511   GH833913   GH834267   GH834671   GH838872   GH851341   GH856277   GH858352   GH860138   GH863808   GH863892   GH867200   GH867844   GH873094   GH876362   GH882007   GH883079   GH883122   GH883362   GH888979   GH889108   GH890928   GH892459   GH892672   GH893177   GH893829   GH894928   GH895763   GH898791   GH899863   GH902755   GH904587   GH906420   GH911565   GH914394   GH915667   GH919442   GH920404   GH922772   GH927115   GH928308   GH929379
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IP18 Q9V3W1 Q8IGL2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    306 Larval Midgut    340.5 Larval Hindgut    274 Larval Malpighian Tubules    351.7 Larval Fat Body    375 Larval Salivary Gland    224.8 Larval Trachea    179.45 Larval Carcass    325.7 Adult Head    276.5 Adult Eye    124.45 Adult Brain    423 Adult Thoracic-Abdominal Ganglion    327.9 Adult Crop    297.8 Adult Midgut    349.4 Adult Hindgut    243.5 Adult Malpighian Tubules    585.1 Adult Fat Body    473.4 Adult Salivary Gland    177.2 Adult Heart    352.9 Adult VirginFemale Spermatheca    308.9 Adult InseminatedFemale Spermatheca    261.3 Adult Ovary    426.7 Adult Testis    699.3 Adult Male Accessory Gland    205.2 Adult Carcass    469.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    306 Larval Midgut    340.5 Larval Hindgut    274 Larval Malpighian Tubules    351.7 Larval Fat Body    375 Larval Salivary Gland    224.8 Larval Trachea    179.45 Larval Carcass    325.7 Adult Head    276.5 Adult Eye    124.45 Adult Brain    423 Adult Thoracic-Abdominal Ganglion    327.9 Adult Crop    297.8 Adult Midgut    349.4 Adult Hindgut    243.5 Adult Malpighian Tubules  (585.1) Adult Fat Body    473.4 Adult Salivary Gland    177.2 Adult Heart    352.9 Adult VirginFemale Spermatheca    308.9 Adult InseminatedFemale Spermatheca    261.3 Adult Ovary    426.7 Adult Testis  (699.3) Adult Male Accessory Gland    205.2 Adult Carcass    469.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    306 Larval Midgut    340.5 Larval Hindgut    274 Larval Malpighian Tubules    351.7 Larval Fat Body    375 Larval Salivary Gland    224.8 Larval Trachea    179.45 Larval Carcass    325.7 Adult Head    276.5 Adult Eye    124.45 Adult Brain    423 Adult Thoracic-Abdominal Ganglion    327.9 Adult Crop    297.8 Adult Midgut    349.4 Adult Hindgut    243.5 Adult Malpighian Tubules    585.1 Adult Fat Body    473.4 Adult Salivary Gland    177.2 Adult Heart    352.9 Adult VirginFemale Spermatheca    308.9 Adult InseminatedFemale Spermatheca    261.3 Adult Ovary    426.7 Adult Testis    699.3 Adult Male Accessory Gland    205.2 Adult Carcass    469.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    306 Larval Midgut    340.5 Larval Hindgut    274 Larval Malpighian Tubules    351.7 Larval Fat Body    375 Larval Salivary Gland    224.8 Larval Trachea    179.45 Larval Carcass    325.7 Adult Head    276.5 Adult Eye    124.45 Adult Brain    423 Adult Thoracic-Abdominal Ganglion    327.9 Adult Crop    297.8 Adult Midgut    349.4 Adult Hindgut    243.5 Adult Malpighian Tubules    585.1 Adult Fat Body    473.4 Adult Salivary Gland    177.2 Adult Heart    352.9 Adult VirginFemale Spermatheca    308.9 Adult InseminatedFemale Spermatheca    261.3 Adult Ovary    426.7 Adult Testis    699.3 Adult Male Accessory Gland    205.2 Adult Carcass    469.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    306 Larval Midgut    340.5 Larval Hindgut    274 Larval Malpighian Tubules    351.7 Larval Fat Body    375 Larval Salivary Gland    224.8 Larval Trachea    179.45 Larval Carcass    325.7 Adult Head    276.5 Adult Eye    124.45 Adult Brain    423 Adult Thoracic-Abdominal Ganglion    327.9 Adult Crop    297.8 Adult Midgut    349.4 Adult Hindgut    243.5 Adult Malpighian Tubules    585.1 Adult Fat Body    473.4 Adult Salivary Gland    177.2 Adult Heart    352.9 Adult VirginFemale Spermatheca    308.9 Adult InseminatedFemale Spermatheca    261.3 Adult Ovary    426.7 Adult Testis    699.3 Adult Male Accessory Gland    205.2 Adult Carcass    469.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    306 Larval Midgut    340.5 Larval Hindgut    274 Larval Malpighian Tubules    351.7 Larval Fat Body    375 Larval Salivary Gland    224.8 Larval Trachea    179.45 Larval Carcass    325.7 Adult Head    276.5 Adult Eye    124.45 Adult Brain    423 Adult Thoracic-Abdominal Ganglion    327.9 Adult Crop    297.8 Adult Midgut    349.4 Adult Hindgut    243.5 Adult Malpighian Tubules  585.1 Adult Fat Body    473.4 Adult Salivary Gland    177.2 Adult Heart    352.9 Adult VirginFemale Spermatheca    308.9 Adult InseminatedFemale Spermatheca    261.3 Adult Ovary    426.7 Adult Testis  699.3 Adult Male Accessory Gland    205.2 Adult Carcass    469.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    306 Larval Midgut    340.5 Larval Hindgut    274 Larval Malpighian Tubules    351.7 Larval Fat Body    375 Larval Salivary Gland    224.8 Larval Trachea    179.45 Larval Carcass    325.7 Adult Head    276.5 Adult Eye    124.45 Adult Brain    423 Adult Thoracic-Abdominal Ganglion    327.9 Adult Crop    297.8 Adult Midgut    349.4 Adult Hindgut    243.5 Adult Malpighian Tubules    585.1 Adult Fat Body    473.4 Adult Salivary Gland    177.2 Adult Heart    352.9 Adult VirginFemale Spermatheca    308.9 Adult InseminatedFemale Spermatheca    261.3 Adult Ovary    426.7 Adult Testis    699.3 Adult Male Accessory Gland    205.2 Adult Carcass    469.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    306 Larval Midgut    340.5 Larval Hindgut    274 Larval Malpighian Tubules    351.7 Larval Fat Body    375 Larval Salivary Gland    224.8 Larval Trachea    179.45 Larval Carcass    325.7 Adult Head    276.5 Adult Eye    124.45 Adult Brain    423 Adult Thoracic-Abdominal Ganglion    327.9 Adult Crop    297.8 Adult Midgut    349.4 Adult Hindgut    243.5 Adult Malpighian Tubules    585.1 Adult Fat Body    473.4 Adult Salivary Gland    177.2 Adult Heart    352.9 Adult VirginFemale Spermatheca    308.9 Adult InseminatedFemale Spermatheca    261.3 Adult Ovary    426.7 Adult Testis    699.3 Adult Male Accessory Gland    205.2 Adult Carcass    469.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    276.5   NA  Eye    124.45   NA  Brain    423   306  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    327.9   NA  Crop    297.8   340.5  Midgut    349.4   274  Hindgut    243.5   351.7  Malpighian Tubules    585.1   375  Fat Body    473.4   224.8  Salivary Gland    177.2   NA  Heart    352.9   179.45  Trachea    NA   NA  VirginFemale Spermatheca    308.9   NA  InseminatedFemale Spermatheca    261.3   NA  Ovary    426.7   NA  Testis    699.3   NA  Male Accessory Gland    205.2   325.7  Carcass    469.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    84 central nervous system, larvae L3    55 central nervous system, pupae P8    84 head, virgin 1-day female    45 head, virgin 4-day female    35 head, virgin 20-day female    28 head, mated 1-day female    38 head, mated 4-day female    33 head, mated 20-day female    25 head, mated 1-day male    54 head, mated 4-day male    46 head, mated 20-day male    51 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    178 digestive system, larvae L3 wandering    85 digestive system, 1-day adult    43 digestive system, 4-day adult    46 digestive system, 20-day adult    40 fat body, larvae L3 wandering    14 fat body, white prepupae    43 fat body, pupae P8    66 carcass, larvae L3 wandering    63 carcass, 1-day adult    54 carcass, 4-day adult    49 carcass, 20-day adult    41 ovary, virgin 4-day female    110 ovary, mated 4-day female    107 testis, mated 4-day male    76 accessory gland, mated 4-day male    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (84) central nervous system, larvae L3  (55) central nervous system, pupae P8  (84) head, virgin 1-day female  (45) head, virgin 4-day female  (35) head, virgin 20-day female  (28) head, mated 1-day female  (38) head, mated 4-day female  (33) head, mated 20-day female    25 head, mated 1-day male  (54) head, mated 4-day male  (46) head, mated 20-day male  (51) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae  (178) digestive system, larvae L3 wandering  (85) digestive system, 1-day adult  (43) digestive system, 4-day adult  (46) digestive system, 20-day adult  (40) fat body, larvae L3 wandering    14 fat body, white prepupae  (43) fat body, pupae P8  (66) carcass, larvae L3 wandering  (63) carcass, 1-day adult  (54) carcass, 4-day adult  (49) carcass, 20-day adult  (41) ovary, virgin 4-day female  (110) ovary, mated 4-day female  (107) testis, mated 4-day male  (76) accessory gland, mated 4-day male  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    84 central nervous system, larvae L3    55 central nervous system, pupae P8    84 head, virgin 1-day female    45 head, virgin 4-day female    35 head, virgin 20-day female    28 head, mated 1-day female    38 head, mated 4-day female    33 head, mated 20-day female    25 head, mated 1-day male    54 head, mated 4-day male    46 head, mated 20-day male    51 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae  (178) digestive system, larvae L3 wandering    85 digestive system, 1-day adult    43 digestive system, 4-day adult    46 digestive system, 20-day adult    40 fat body, larvae L3 wandering    14 fat body, white prepupae    43 fat body, pupae P8    66 carcass, larvae L3 wandering    63 carcass, 1-day adult    54 carcass, 4-day adult    49 carcass, 20-day adult    41 ovary, virgin 4-day female  (110) ovary, mated 4-day female  107 testis, mated 4-day male    76 accessory gland, mated 4-day male    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    84 central nervous system, larvae L3    55 central nervous system, pupae P8    84 head, virgin 1-day female    45 head, virgin 4-day female    35 head, virgin 20-day female    28 head, mated 1-day female    38 head, mated 4-day female    33 head, mated 20-day female    25 head, mated 1-day male    54 head, mated 4-day male    46 head, mated 20-day male    51 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    178 digestive system, larvae L3 wandering    85 digestive system, 1-day adult    43 digestive system, 4-day adult    46 digestive system, 20-day adult    40 fat body, larvae L3 wandering    14 fat body, white prepupae    43 fat body, pupae P8    66 carcass, larvae L3 wandering    63 carcass, 1-day adult    54 carcass, 4-day adult    49 carcass, 20-day adult    41 ovary, virgin 4-day female    110 ovary, mated 4-day female    107 testis, mated 4-day male    76 accessory gland, mated 4-day male    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    84 central nervous system, larvae L3    55 central nervous system, pupae P8    84 head, virgin 1-day female    45 head, virgin 4-day female    35 head, virgin 20-day female    28 head, mated 1-day female    38 head, mated 4-day female    33 head, mated 20-day female    25 head, mated 1-day male    54 head, mated 4-day male    46 head, mated 20-day male    51 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    178 digestive system, larvae L3 wandering    85 digestive system, 1-day adult    43 digestive system, 4-day adult    46 digestive system, 20-day adult    40 fat body, larvae L3 wandering    14 fat body, white prepupae    43 fat body, pupae P8    66 carcass, larvae L3 wandering    63 carcass, 1-day adult    54 carcass, 4-day adult    49 carcass, 20-day adult    41 ovary, virgin 4-day female    110 ovary, mated 4-day female    107 testis, mated 4-day male    76 accessory gland, mated 4-day male    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (84) central nervous system, larvae L3  (55) central nervous system, pupae P8  (84) head, virgin 1-day female  (45) head, virgin 4-day female  (35) head, virgin 20-day female  28 head, mated 1-day female  (38) head, mated 4-day female  (33) head, mated 20-day female    25 head, mated 1-day male  (54) head, mated 4-day male  (46) head, mated 20-day male  (51) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae  (178) digestive system, larvae L3 wandering  (85) digestive system, 1-day adult  (43) digestive system, 4-day adult  (46) digestive system, 20-day adult  (40) fat body, larvae L3 wandering    14 fat body, white prepupae  (43) fat body, pupae P8  (66) carcass, larvae L3 wandering  (63) carcass, 1-day adult  (54) carcass, 4-day adult  (49) carcass, 20-day adult  (41) ovary, virgin 4-day female  (110) ovary, mated 4-day female  (107) testis, mated 4-day male  (76) accessory gland, mated 4-day male  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    84 central nervous system, larvae L3    55 central nervous system, pupae P8    84 head, virgin 1-day female    45 head, virgin 4-day female    35 head, virgin 20-day female    28 head, mated 1-day female    38 head, mated 4-day female    33 head, mated 20-day female    25 head, mated 1-day male    54 head, mated 4-day male    46 head, mated 20-day male    51 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae  (178) digestive system, larvae L3 wandering    85 digestive system, 1-day adult    43 digestive system, 4-day adult    46 digestive system, 20-day adult    40 fat body, larvae L3 wandering    14 fat body, white prepupae    43 fat body, pupae P8    66 carcass, larvae L3 wandering    63 carcass, 1-day adult    54 carcass, 4-day adult    49 carcass, 20-day adult    41 ovary, virgin 4-day female  110 ovary, mated 4-day female  107 testis, mated 4-day male    76 accessory gland, mated 4-day male    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    84 central nervous system, larvae L3    55 central nervous system, pupae P8    84 head, virgin 1-day female    45 head, virgin 4-day female    35 head, virgin 20-day female    28 head, mated 1-day female    38 head, mated 4-day female    33 head, mated 20-day female    25 head, mated 1-day male    54 head, mated 4-day male    46 head, mated 20-day male    51 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    178 digestive system, larvae L3 wandering    85 digestive system, 1-day adult    43 digestive system, 4-day adult    46 digestive system, 20-day adult    40 fat body, larvae L3 wandering    14 fat body, white prepupae    43 fat body, pupae P8    66 carcass, larvae L3 wandering    63 carcass, 1-day adult    54 carcass, 4-day adult    49 carcass, 20-day adult    41 ovary, virgin 4-day female    110 ovary, mated 4-day female    107 testis, mated 4-day male    76 accessory gland, mated 4-day male    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    121 embryo 02-04hr    183 embryo 04-06hr    128 embryo 06-08hr    143 embryo 08-10hr    131 embryo 10-12hr    104 embryo 12-14hr    96 embryo 14-16hr    99 embryo 16-18hr    100 embryo 18-20hr    100 embryo 20-22hr    136 embryo 22-24hr    132 larva L1    72 larva L2    55 larva L3 12hr old    52 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    58 larva L3 puffstage 7-9    79 white prepupae new    131 white prepupae 12hr    111 white prepupae 24hr    93 pupae 2d postWPP    127 pupae 3d postWPP    120 pupae 4d postWPP    135 adult male 01day    95 adult male 05day    92 adult male 30day    83 adult female 01day    84 adult female 05day    92 adult female 30day    89 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (121) embryo 02-04hr  (183) embryo 04-06hr  (128) embryo 06-08hr  (143) embryo 08-10hr  (131) embryo 10-12hr  (104) embryo 12-14hr  (96) embryo 14-16hr  (99) embryo 16-18hr  (100) embryo 18-20hr  (100) embryo 20-22hr  (136) embryo 22-24hr  (132) larva L1  (72) larva L2  (55) larva L3 12hr old  (52) larva L3 puffstage 1-2  (45) larva L3 puffstage 3-6  (58) larva L3 puffstage 7-9  (79) white prepupae new  (131) white prepupae 12hr  (111) white prepupae 24hr  (93) pupae 2d postWPP  (127) pupae 3d postWPP  (120) pupae 4d postWPP  (135) adult male 01day  (95) adult male 05day  (92) adult male 30day  (83) adult female 01day  (84) adult female 05day  (92) adult female 30day  (89) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (121) embryo 02-04hr  (183) embryo 04-06hr  (128) embryo 06-08hr  (143) embryo 08-10hr  (131) embryo 10-12hr  104 embryo 12-14hr    96 embryo 14-16hr    99 embryo 16-18hr    100 embryo 18-20hr    100 embryo 20-22hr  (136) embryo 22-24hr  (132) larva L1    72 larva L2    55 larva L3 12hr old    52 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    58 larva L3 puffstage 7-9    79 white prepupae new  (131) white prepupae 12hr  (111) white prepupae 24hr    93 pupae 2d postWPP  (127) pupae 3d postWPP  (120) pupae 4d postWPP  (135) adult male 01day    95 adult male 05day    92 adult male 30day    83 adult female 01day    84 adult female 05day    92 adult female 30day    89 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    121 embryo 02-04hr    183 embryo 04-06hr    128 embryo 06-08hr    143 embryo 08-10hr    131 embryo 10-12hr    104 embryo 12-14hr    96 embryo 14-16hr    99 embryo 16-18hr    100 embryo 18-20hr    100 embryo 20-22hr    136 embryo 22-24hr    132 larva L1    72 larva L2    55 larva L3 12hr old    52 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    58 larva L3 puffstage 7-9    79 white prepupae new    131 white prepupae 12hr    111 white prepupae 24hr    93 pupae 2d postWPP    127 pupae 3d postWPP    120 pupae 4d postWPP    135 adult male 01day    95 adult male 05day    92 adult male 30day    83 adult female 01day    84 adult female 05day    92 adult female 30day    89 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    121 embryo 02-04hr    183 embryo 04-06hr    128 embryo 06-08hr    143 embryo 08-10hr    131 embryo 10-12hr    104 embryo 12-14hr    96 embryo 14-16hr    99 embryo 16-18hr    100 embryo 18-20hr    100 embryo 20-22hr    136 embryo 22-24hr    132 larva L1    72 larva L2    55 larva L3 12hr old    52 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    58 larva L3 puffstage 7-9    79 white prepupae new    131 white prepupae 12hr    111 white prepupae 24hr    93 pupae 2d postWPP    127 pupae 3d postWPP    120 pupae 4d postWPP    135 adult male 01day    95 adult male 05day    92 adult male 30day    83 adult female 01day    84 adult female 05day    92 adult female 30day    89 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (121) embryo 02-04hr  (183) embryo 04-06hr  (128) embryo 06-08hr  (143) embryo 08-10hr  (131) embryo 10-12hr  (104) embryo 12-14hr  (96) embryo 14-16hr  (99) embryo 16-18hr  (100) embryo 18-20hr  (100) embryo 20-22hr  (136) embryo 22-24hr  (132) larva L1  (72) larva L2  (55) larva L3 12hr old  (52) larva L3 puffstage 1-2  (45) larva L3 puffstage 3-6  (58) larva L3 puffstage 7-9  (79) white prepupae new  (131) white prepupae 12hr  (111) white prepupae 24hr  (93) pupae 2d postWPP  (127) pupae 3d postWPP  (120) pupae 4d postWPP  (135) adult male 01day  (95) adult male 05day  (92) adult male 30day  (83) adult female 01day  (84) adult female 05day  (92) adult female 30day  (89) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  121 embryo 02-04hr  (183) embryo 04-06hr  128 embryo 06-08hr  143 embryo 08-10hr  131 embryo 10-12hr  104 embryo 12-14hr    96 embryo 14-16hr    99 embryo 16-18hr    100 embryo 18-20hr    100 embryo 20-22hr  136 embryo 22-24hr  132 larva L1    72 larva L2    55 larva L3 12hr old    52 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    58 larva L3 puffstage 7-9    79 white prepupae new  131 white prepupae 12hr  111 white prepupae 24hr    93 pupae 2d postWPP  127 pupae 3d postWPP  120 pupae 4d postWPP  135 adult male 01day    95 adult male 05day    92 adult male 30day    83 adult female 01day    84 adult female 05day    92 adult female 30day    89 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    121 embryo 02-04hr    183 embryo 04-06hr    128 embryo 06-08hr    143 embryo 08-10hr    131 embryo 10-12hr    104 embryo 12-14hr    96 embryo 14-16hr    99 embryo 16-18hr    100 embryo 18-20hr    100 embryo 20-22hr    136 embryo 22-24hr    132 larva L1    72 larva L2    55 larva L3 12hr old    52 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    58 larva L3 puffstage 7-9    79 white prepupae new    131 white prepupae 12hr    111 white prepupae 24hr    93 pupae 2d postWPP    127 pupae 3d postWPP    120 pupae 4d postWPP    135 adult male 01day    95 adult male 05day    92 adult male 30day    83 adult female 01day    84 adult female 05day    92 adult female 30day    89 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    56 Schneider line 2 Sg4    44 embryonic 1182-4H    60 embryonic GM2    59 embryonic Kc167    41 embryonic S1    73 embryonic S3    51 leg disc CME L1    61 wing disc CME-W2    54 wing disc ML-DmD8    49 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    73 wing disc ML-DmD21    66 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    60 ovary fGS/OSS    87 ovary OSC    64 ovary OSS    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (56) Schneider line 2 Sg4  (44) embryonic 1182-4H  (60) embryonic GM2  (59) embryonic Kc167  (41) embryonic S1  (73) embryonic S3  (51) leg disc CME L1  (61) wing disc CME-W2  (54) wing disc ML-DmD8  (49) wing disc ML-DmD9  (68) wing disc ML-DmD16-c3  (73) wing disc ML-DmD21  (66) wing disc ML-DmD32  (39) haltere disc ML-DmD17-c3  (61) eye-antennal disc ML-DmD11  (64) antennal disc ML-DmD20-c5  (39) mixed discs ML-DmD4-c1  (62) CNS ML-DmBG1-c1  (50) CNS ML-DmBG2-c2  (54) tumorous blood cells mbn2  (60) ovary fGS/OSS  (87) ovary OSC  (64) ovary OSS  (57) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    56 Schneider line 2 Sg4    44 embryonic 1182-4H    60 embryonic GM2    59 embryonic Kc167    41 embryonic S1    73 embryonic S3    51 leg disc CME L1    61 wing disc CME-W2    54 wing disc ML-DmD8    49 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    73 wing disc ML-DmD21    66 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    60 ovary fGS/OSS    87 ovary OSC    64 ovary OSS    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    56 Schneider line 2 Sg4    44 embryonic 1182-4H    60 embryonic GM2    59 embryonic Kc167    41 embryonic S1    73 embryonic S3    51 leg disc CME L1    61 wing disc CME-W2    54 wing disc ML-DmD8    49 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    73 wing disc ML-DmD21    66 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    60 ovary fGS/OSS    87 ovary OSC    64 ovary OSS    57 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    56 Schneider line 2 Sg4    44 embryonic 1182-4H    60 embryonic GM2    59 embryonic Kc167    41 embryonic S1    73 embryonic S3    51 leg disc CME L1    61 wing disc CME-W2    54 wing disc ML-DmD8    49 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    73 wing disc ML-DmD21    66 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    60 ovary fGS/OSS    87 ovary OSC    64 ovary OSS    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (56) Schneider line 2 Sg4  (44) embryonic 1182-4H  (60) embryonic GM2  (59) embryonic Kc167  (41) embryonic S1  (73) embryonic S3  (51) leg disc CME L1  (61) wing disc CME-W2  (54) wing disc ML-DmD8  (49) wing disc ML-DmD9  (68) wing disc ML-DmD16-c3  (73) wing disc ML-DmD21  (66) wing disc ML-DmD32  (39) haltere disc ML-DmD17-c3  (61) eye-antennal disc ML-DmD11  (64) antennal disc ML-DmD20-c5  (39) mixed discs ML-DmD4-c1  (62) CNS ML-DmBG1-c1  (50) CNS ML-DmBG2-c2  (54) tumorous blood cells mbn2  (60) ovary fGS/OSS  (87) ovary OSC  (64) ovary OSS  (57) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    56 Schneider line 2 Sg4    44 embryonic 1182-4H    60 embryonic GM2    59 embryonic Kc167    41 embryonic S1    73 embryonic S3    51 leg disc CME L1    61 wing disc CME-W2    54 wing disc ML-DmD8    49 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    73 wing disc ML-DmD21    66 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    60 ovary fGS/OSS    87 ovary OSC    64 ovary OSS    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    56 Schneider line 2 Sg4    44 embryonic 1182-4H    60 embryonic GM2    59 embryonic Kc167    41 embryonic S1    73 embryonic S3    51 leg disc CME L1    61 wing disc CME-W2    54 wing disc ML-DmD8    49 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    73 wing disc ML-DmD21    66 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    60 ovary fGS/OSS    87 ovary OSC    64 ovary OSS    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    52 heat shock, 4-day adult    61 Cadmium 50 mM 6 hrs, larvae L3    36 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    63 Cadmium 100 mM 48 hrs, 4-day adult    83 Copper 0.5 mM 12 hrs, larvae L3    49 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    43 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    92 Ethanol 5% 3 hrs, larvae L3    40 Ethanol 10% 3 hrs, larvae L3    42 Caffeine 1.5 mg/ml 4 hrs, larvae L3    34 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    80 Caffeine 25 mg/ml 48 hrs, 4-day adult    52 Paraquat 5 mM 48 hrs, 4-day adult    72 Paraquat 10 mM 48 hrs, 4-day adult    77 Rotenone 2 μg 12 hrs, larvae L3    42 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (61) cold shock, 4-day adult  (52) heat shock, 4-day adult  (61) Cadmium 50 mM 6 hrs, larvae L3  (36) Cadmium 50 mM 12 hrs, larvae L3  (50) Cadmium 50 mM 48 hrs, 4-day adult  (63) Cadmium 100 mM 48 hrs, 4-day adult  (83) Copper 0.5 mM 12 hrs, larvae L3  (49) Copper 15 mM 48 hrs, 4-day adult  (70) Zinc 5 mM 12 hrs, larvae L3  (43) Zinc 4.5 mM 48 hrs, 4-day adult  (58) Ethanol 2.5% 3 hrs, larvae L3  (92) Ethanol 5% 3 hrs, larvae L3  (40) Ethanol 10% 3 hrs, larvae L3  (42) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (34) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (80) Caffeine 25 mg/ml 48 hrs, 4-day adult  (52) Paraquat 5 mM 48 hrs, 4-day adult  (72) Paraquat 10 mM 48 hrs, 4-day adult  (77) Rotenone 2 μg 12 hrs, larvae L3  (42) Rotenone 8 μg 12 hrs, larvae L3  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    52 heat shock, 4-day adult    61 Cadmium 50 mM 6 hrs, larvae L3    36 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    63 Cadmium 100 mM 48 hrs, 4-day adult    83 Copper 0.5 mM 12 hrs, larvae L3    49 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    43 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    92 Ethanol 5% 3 hrs, larvae L3    40 Ethanol 10% 3 hrs, larvae L3    42 Caffeine 1.5 mg/ml 4 hrs, larvae L3    34 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    80 Caffeine 25 mg/ml 48 hrs, 4-day adult    52 Paraquat 5 mM 48 hrs, 4-day adult    72 Paraquat 10 mM 48 hrs, 4-day adult    77 Rotenone 2 μg 12 hrs, larvae L3    42 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    52 heat shock, 4-day adult    61 Cadmium 50 mM 6 hrs, larvae L3    36 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    63 Cadmium 100 mM 48 hrs, 4-day adult    83 Copper 0.5 mM 12 hrs, larvae L3    49 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    43 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    92 Ethanol 5% 3 hrs, larvae L3    40 Ethanol 10% 3 hrs, larvae L3    42 Caffeine 1.5 mg/ml 4 hrs, larvae L3    34 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    80 Caffeine 25 mg/ml 48 hrs, 4-day adult    52 Paraquat 5 mM 48 hrs, 4-day adult    72 Paraquat 10 mM 48 hrs, 4-day adult    77 Rotenone 2 μg 12 hrs, larvae L3    42 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    52 heat shock, 4-day adult    61 Cadmium 50 mM 6 hrs, larvae L3    36 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    63 Cadmium 100 mM 48 hrs, 4-day adult    83 Copper 0.5 mM 12 hrs, larvae L3    49 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    43 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    92 Ethanol 5% 3 hrs, larvae L3    40 Ethanol 10% 3 hrs, larvae L3    42 Caffeine 1.5 mg/ml 4 hrs, larvae L3    34 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    80 Caffeine 25 mg/ml 48 hrs, 4-day adult    52 Paraquat 5 mM 48 hrs, 4-day adult    72 Paraquat 10 mM 48 hrs, 4-day adult    77 Rotenone 2 μg 12 hrs, larvae L3    42 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (61) cold shock, 4-day adult  (52) heat shock, 4-day adult  (61) Cadmium 50 mM 6 hrs, larvae L3  (36) Cadmium 50 mM 12 hrs, larvae L3  (50) Cadmium 50 mM 48 hrs, 4-day adult  (63) Cadmium 100 mM 48 hrs, 4-day adult  (83) Copper 0.5 mM 12 hrs, larvae L3  (49) Copper 15 mM 48 hrs, 4-day adult  (70) Zinc 5 mM 12 hrs, larvae L3  (43) Zinc 4.5 mM 48 hrs, 4-day adult  (58) Ethanol 2.5% 3 hrs, larvae L3  (92) Ethanol 5% 3 hrs, larvae L3  (40) Ethanol 10% 3 hrs, larvae L3  (42) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (34) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (80) Caffeine 25 mg/ml 48 hrs, 4-day adult  (52) Paraquat 5 mM 48 hrs, 4-day adult  (72) Paraquat 10 mM 48 hrs, 4-day adult  (77) Rotenone 2 μg 12 hrs, larvae L3  (42) Rotenone 8 μg 12 hrs, larvae L3  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    52 heat shock, 4-day adult    61 Cadmium 50 mM 6 hrs, larvae L3    36 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    63 Cadmium 100 mM 48 hrs, 4-day adult    83 Copper 0.5 mM 12 hrs, larvae L3    49 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    43 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    92 Ethanol 5% 3 hrs, larvae L3    40 Ethanol 10% 3 hrs, larvae L3    42 Caffeine 1.5 mg/ml 4 hrs, larvae L3    34 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    80 Caffeine 25 mg/ml 48 hrs, 4-day adult    52 Paraquat 5 mM 48 hrs, 4-day adult    72 Paraquat 10 mM 48 hrs, 4-day adult    77 Rotenone 2 μg 12 hrs, larvae L3    42 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    61 cold shock, 4-day adult    52 heat shock, 4-day adult    61 Cadmium 50 mM 6 hrs, larvae L3    36 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    63 Cadmium 100 mM 48 hrs, 4-day adult    83 Copper 0.5 mM 12 hrs, larvae L3    49 Copper 15 mM 48 hrs, 4-day adult    70 Zinc 5 mM 12 hrs, larvae L3    43 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    92 Ethanol 5% 3 hrs, larvae L3    40 Ethanol 10% 3 hrs, larvae L3    42 Caffeine 1.5 mg/ml 4 hrs, larvae L3    34 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    80 Caffeine 25 mg/ml 48 hrs, 4-day adult    52 Paraquat 5 mM 48 hrs, 4-day adult    72 Paraquat 10 mM 48 hrs, 4-day adult    77 Rotenone 2 μg 12 hrs, larvae L3    42 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032586 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4599-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Tpr2GD10712 Other Phenotypes Allele visible, with Scer\GAL4Cha.7.4 Tpr2Scer\UAS.cKa visible, with Scer\GAL4Mhc.PW Tpr2Scer\UAS.cKa Phenotype manifest in Allele eye, with Scer\GAL4Cha.7.4 Tpr2Scer\UAS.cKa wing, with Scer\GAL4Mhc.PW Tpr2Scer\UAS.cKa
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of Tpr2 Class Mutagen Stocks Known lesion Tpr2KG08262 P-element activity 2 -- Tpr2EU3220 P-element activity 1 Yes Tpr2EY21644 P-element activity 1 -- Tpr2f06865 piggyBac transposase 1 -- Tpr2f07065 piggyBac transposase 1 -- Tpr2c07031 piggyBac transposase 0 -- Tpr2c07037 piggyBac transposase 0 -- Tpr2DG05811 P-element activity 0 -- Tpr2EB7-1A 0 -- Tpr2k07510 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tpr2 Class Mutagen Stocks Known lesion Tpr2GD10712 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Tpr2Scer\UAS.cKa in vitro construct - regulatory fusion 2 Yes Tpr2KK101629 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tpr2NIG.4599R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7065 (Ryder, 2004.4.26) Df(2L)Exel7066 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10712} NA P{KK101629} NA P{NIG.4599R} NA P{UAS-Tpr2.K} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}Tpr2KG08262 NA P{wHy}Tpr2DG05811 NA PBac{PB}Tpr2c07031 NA PBac{PB}Tpr2c07037 NA PBac{WH}Tpr2f06865 NA PBac{WH}Tpr2f07065 NA insertion of enhancer trap P{lacW}Tpr2k07510 No insertion of mobile activating element P{EP}Tpr2EB7-1A NA P{EP}Tpr2EU3220 NA P{EPgy2}Tpr2EY21644 NA P{GSV1}C877C877 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2013-02-07)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
unfolded protein binding inferred from sequence or structural similarity with E.coli dnaJ (Curators, 2008--)
Biological Process
CV term Evidence References
protein folding inferred from sequence or structural similarity with E.coli dnaJ (Curators, 2008--)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tpr2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60993 DroID - A comprehensive database of gene and protein interactions. • FBgn0032586 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34984
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6S1TSX Dipteran inclusive ortholog search EOG6JM7Z4 Insect inclusive ortholog search EOG6BK40N Arthropod inclusive ortholog search EOG6GTHVM Metazoa inclusive ortholog search EOG6677DW
Orthologs in Drosophila Species (EOG6S1TSX)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Tpr2     Drosophila simulans   Dsim\GD24060 Y   Drosophila sechellia   Dsec\GM17182 Y   Drosophila erecta   Dere\GG22751 Y   Drosophila yakuba   Dyak\GE12746 Y   Drosophila ananassae   Dana\GF13997 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18289 Y   Drosophila persimilis   Dper\GL19640 Y   Drosophila willistoni   Dwil\GK24713 Y   Drosophila virilis   Dvir\GJ22670 Y   Drosophila mojavensis   Dmoj\GI17261 Y   Drosophila grimshawi   Dgri\GH25192 Y   Drosophila grimshawi   Dgri\GH23190
Orthologs in non-Drosophila Dipterans (EOG6JM7Z4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001896   Anopheles gambiae Malaria mosquito  Agam\AGAP008985   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010968
Orthologs in non-Dipteran Insects (EOG6BK40N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC410037   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011938   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15994   Atta cephalotes Leafcutter ant  Acep\ACEP14696   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13492   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17679   Linepithema humile Argentine ant  Lhum\LH11128   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20505   Solenopsis invicta Red fire ant  Sinv\SINV13303   Bombyx mori Silkmoth  Bmor\BGIBMGA006193   Pediculus humanus Human body louse  Phum\PHUM462210   Tribolium castaneum Red flour beetle  Tcas\TC014273
Orthologs in non-Insect Arthropods (EOG6GTHVM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\RNF149   Ixodes scapularis Deer tick  Isca\ISCW020152
Orthologs in non-Arthropod Metazoa (EOG6677DW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008572gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019877gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023947gn   Danio rerio Zebrafish  Drer\dnajc7   Danio rerio Zebrafish  Drer\ENSDARG00000058148   Xenopus tropicalis Western clawed frog  Xtro\dnajc7   Gallus gallus Domestic chicken  Ggal\DNAJC7   Mus musculus House mouse  Mmus\Dnajc7   Rattus norvegicus Norway rat  Rnor\Dnajc7   Homo sapiens Human  Hsap\DNAJC7
Human Orthologs (1)
Gene OMIM HGNC Hsap\DNAJC7
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24060 Drosophila sechellia Dsec\GM17182 Drosophila erecta Dere\GG22751 Drosophila yakuba Dyak\GE12746 Drosophila ananassae Dana\GF13997 Drosophila pseudoobscura pseudoobscura Dpse\GA18289 Drosophila persimilis Dper\GL19640 Drosophila willistoni Dwil\GK24713 Drosophila virilis Dvir\GJ22670 Drosophila mojavensis Dmoj\GI17261 Drosophila grimshawi Dgri\GH25192
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	30545 w*; P{UAS-Tpr2.K}2 30548 w*; P{UAS-Tpr2.K}3 30552 w*; P{EP}Tpr2EU3220 22491 y1 w67c23; P{EPgy2}Tpr2EY21644 14711 y1; P{SUPor-P}Tpr2KG08262/CyO; ry506
Harvard	- PBac{WH}Tpr2f06865 - PBac{WH}Tpr2f07065
Kyoto	111623 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}Tpr2KG08262 P{neoFRT}40A/CyO y+
VDRC	v107813 P{KK101629}VIE-260B v26077 w1118; P{GD10712}v26077 v26075 w1118; P{GD10712}v26075/TM3
Genomic Clones ( 2 )
	BACR33A07 BACR44N04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 241 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM02532 RE69804 RH52721
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04370 AT05620 AT06137 AT07651 AT12273 AT13060 AT14826 AT16183 AT18269 AT20785 AT23153 AT29234 GH09432 GH27587 LD03117 LD03816 LD04420 LD04514 LD10289 LD12231 LD12892 LD12936 LD14276 LD15082 LD15878 LD20852 LD21413 LD23475 LD24294 LD25811 LD28460 LD28780 LD29019 LD30903 LD31359 LD31367 LD32912 LD35591 LD35876 LD36615 LD37269 LD39563 LD41274 LD42079 LD42803 LD46089 LD47939 LP17666 LP23241 RE02107 RE02958 RE04718 RE05062 RE05156 RE07078 RE09094 RE10434 RE11260 RE11739 RE11815 RE12240 RE19042 RE19267 RE22818 RE23648 RE24838 RE25542 RE26332 RE28111 RE28684 RE29464 RE29637 RE29863 RE30440 RE33378 RE34655 RE35466 RE36379 RE36396 RE40441 RE47065 RE48556 RE48613 RE52669 RE53041 RE59114 RE62236 RE62389 RE62548 RE62601 RE62989 RE67392 RE68122 RE69112 RE71842 RE73129 RE74815 RH09847 RH15356 RH50713 RH56033 RH64236 SD25993
Other clones	39671 56424 60372 62498 71269 72838 77089 81931 102323 158985 175941 176638 214471.26 283325 522765 AT12911 bs14h11 CK01.25A.D2 CK01.50D.C11 CK01.51A.G10 CK01.99B.F2 CK01.101C.D3 CK01.117D.A2 CK01.125A.F11 Dmel_dig_011031_0586_2680 EC30863 EK041810 EK056207 EK063257 EK078614 EK085611 EK095424 EK111015 EK153263 EK167104 EK168714 EK184615 EK187759 EK199127 EK215431 EK225534 EK242925 EK252944 EK261830 EK266305 EK277955 EK280931 EK281142 EN02739 EN10836 EP03464 FGC018D05 GH09433 LD24941 RC0-DP0007-150700-011-E11 RP003000541 RP003021535 RP003031868 RP003035313 RP003041788 RP003052838 RP003056589 RP003056611 RP003060630 RP003077642 RP003078948 RP003091648 RP003092465 RP003098830 RP003111507 RP003123354 RP003125535 RP003126123 RP003129200 RP003141878 RP003149025 RP003167807 RP003168079 RP003175050 RP003185045 RP003185649 RP003189683 RP003192602 RP003205052 RP003208856 RP003223592 RP003225989 RP003227204 RP003230788 RP003238767 RP003246676 RP003256627 RP003286960 RP003289099 RP003290348 RP003302999 RP003303949 RP003305983 RP003310897 RP003327449 RP003336122 RP003341730 RP003389863 RP003405588 RP003420462 RP003430521 RP003431920 RP003432698 RP003435554 RP003437114 RP003437961 RP003454010 RP003455066 RP003466654 RP003509408 RP003514857 RP003531757 RP003546825 RP003551391 RP003557817 RP003561656 RP003579044 RP003580071 RP003582674 RP003583397 RP003591677 RP003593287 RP003597739 RP003601685 RP003605268 RP003614162 RP003622412 RP003635821 RP003650881 RP003669158
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032586 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34984
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tpr2 CG4599 (FlyBase, 1996-)
Source for database merge of	Source for merge of: Tpr2 BEST:LD24941 (Rana, 2004.7.8)
Additional comments	Source for identity of Tpr2 CG4599 was sequence comparison (date:000327). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078860 NM_165164 NM_001273571 NM_001273572 NM_001273573 RefSeq (Proteins) • NP_523584 NP_723974 NP_001260500 NP_001260501 NP_001260502 DDBJ / EMBL / GenBank • AA695280 AAF43627 AAF53540 AAN10946 AAN71480 AF199022 AGB93035 AGB93036 AGB93037 AI110008 AI455565 AI514849 AI945073 AI945627 AW941168 BH901016 BI486386 BI619638 BT001725 CZ471179 CZ471186 CZ489597 CZ489828 CZ489829 Entrez Gene - A searchable database of RefSeq genes. • 34984 UniProtKB/TrEMBL • Q8IGL2 Q8IP18 Q9V3W1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DnaJ domain, conserved site (IPR018253) DnaJ domain (IPR001623) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing domain (IPR013026) Tetratricopeptide repeat (IPR019734) Tetratricopeptide TPR-1 (IPR001440) Tetratricopeptide TPR2 (IPR013105)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60993 DroID - A comprehensive database of gene and protein interactions. • FBgn0032586 DRSC - Results from RNAi screens. • FBgn0032586 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032586 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4599-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032586 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34984 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34984 modMine - Data generated by the modENCODE project. • FBgn0032586
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	BEST:LD24941   CG4599 (Quinones-Coello, 2007, Molnar et al., 2006, Keleman et al., 2009.8.5) dTPR2 (Kapahi et al., 2002, Orr, 2001, Kazemi-Esfarjani and Benzer, 2000) dtpr2 (Kazemi-Esfarjani, 1999.10.26) dTpr2 (Liévens et al., 2008) dtrpr2 (Chartier et al., 2006) EU3220 (Kazemi-Esfarjani and Benzer, 2000) tpr2 (Pappu et al., 2005) Tpr2 (Quinones-Coello, 2007, Gan et al., 2010, Bilen and Bonini, 2007, Shieh and Bonini, 2011, Japanese National Institute of Genetics, 2012.5.21) Tpr-2 (Ghosh and Feany, 2004) Trp2 (Molnar et al., 2006)
Name Synonym	Tetratricopeptide repeat protein 2 (Kazemi-Esfarjani, 1999.10.26) tetratricopeptide repeat protein 2 (Shieh and Bonini, 2011)
Secondary FlyBase IDs
	FBgn0046263
References ( 38 )
Generate a list of	All references relating to this gene ( 38 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 1 ) FlyBase analysis  ( 5 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Shieh and Bonini, 2011, Hum. Mol. Genet. 20(24): 4810--4821 Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila. [FBrf0216738] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...