FB2021_01, released Feb 18, 2021

Gene: Dmel\CG5110

Open Close
General Information
Symbol
Dmel\CG5110
Species
D. melanogaster
Name
Annotation Symbol
CG5110
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032642
Gene Model Status
Current
Stock Availability
3 publicly available
Gene Snapshot
CG5110 encodes a scaffold protein that associates with the MAP kinase kinase and the MAP kinase encoded by Mekk1 and rl respectively. It regulates the vein promoting function of rl during wing imaginal disc development in third instar larvae. [Date last reviewed: 2019-09-26]
Other Summaries
Also Known As

MP1, dMP1

Key Links
Genomic Location
Cytogenetic map
36C10-36C10
Sequence location
2L:17,481,231..17,482,037 [+]
Recombination map

2-53

RefSeq locus
NT_033779 REGION:17481231..17482037
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
contributes_to guanyl-nucleotide exchange factor activity
inferred from sequence or structural similarity with UniProtKB:Q9UHA4
(assigned by UniProt )
(UniProt Curators, 2002-)
contributes_to molecular adaptor activity
inferred from sequence or structural similarity with UniProtKB:Q9UHA4
(assigned by UniProt )
(UniProt Curators, 2002-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in cellular response to amino acid stimulus
inferred from mutant phenotype
(Sancak et al., 2010)
involved_in positive regulation of TOR signaling
inferred from mutant phenotype
(assigned by UniProt )
(Sancak et al., 2010)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in cellular protein localization
inferred from sequence or structural similarity with UniProtKB:Q9UHA4
(assigned by UniProt )
(UniProt Curators, 2002-)
involved_in cellular response to amino acid stimulus
inferred from sequence or structural similarity with UniProtKB:Q9UHA4
(assigned by UniProt )
(UniProt Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN001001460
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in positive regulation of TOR signaling
inferred from biological aspect of ancestor with PANTHER:PTN001001460
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of Ragulator complex
inferred from sequence or structural similarity with UniProtKB:Q9UHA4
(assigned by UniProt )
(UniProt Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN001001460
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the LAMTOR3 family. (Q9VJD2)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.
(UniProt, Q9VJD2)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG5110 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG5110-RA
FBtr0080983
NM_135999
548
124
CG5110-RB
FBtr0306162
NM_001259133
729
124
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG5110-PA
FBpp0080536
13.8
124
5.07
NP_609843
AAF53620
CG5110-PB
FBpp0297292
13.8
124
5.07
NP_001246062
AFH03736
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

124 aa isoforms: CG5110-PA, CG5110-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Part of the Ragulator complex composed of CG5110, CG5189, CG14184, CG14812, and CG14977.

(UniProt, Q9VJD2)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG5110 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG5110 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG5110
Transgenic constructs containing regulatory region of CG5110
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation
Gene disrupted in
Df(2L)Exel7068
(Ryder, 2004.4.26)
Inferred from location
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\LAMTOR3
14 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Lamtor3
12 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Lamtor3
13 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\lamtor3-like
12 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\lamtor3
14 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\lmtr-3
5 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190IG7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001122
Drosophila simulans
Dsim\GD24112
Drosophila sechellia
Dsec\GM17242
Drosophila erecta
Dere\GG21091
Drosophila yakuba
Dyak\GE12795
Drosophila ananassae
Dana\GF14799
Drosophila pseudoobscura pseudoobscura
Dpse\GA18666
Drosophila persimilis
Dper\GL14499
Drosophila willistoni
Dwil\GK24182
Drosophila virilis
Dvir\GJ17698
Drosophila mojavensis
Dmoj\GI17925
Drosophila grimshawi
Dgri\GH11622
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150GMY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015161
Glossina morsitans
Tsetse fly
Gmor\GMOY003074
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10166
Mayetiola destructor
Hessian fly
Mdes\Mdes008569
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004056
Anopheles darlingi
American malaria mosquito
Adar\ADAC001502
Anopheles gambiae
Malaria mosquito
Agam\AGAP000997
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009430
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0L7H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009115
Danaus plexippus
Monarch butterfly
Dple\DPOGS201035-PA
Apis florea
Little honeybee
Aflo\2160513956
Apis mellifera
Western honey bee
Amel\GB49403
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17413
Bombus terrestris
Buff-tailed bumblebee
Bter\15213222
Linepithema humile
Argentine ant
Lhum\LH21243
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003962
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03737
Tribolium castaneum
Red flour beetle
Tcas\TC002357
Rhodnius prolixus
Kissing bug
Rpro\RPRC008667
Cimex lectularius
Bed bug
Clec\CLEC001935
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006297
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0LEU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW003946
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74931.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g03360
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_300910
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0TYL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mapkk1ip1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mapkk1ip1
Gallus gallus
Domestic chicken
Ggal\LAMTOR3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
    14 of 15
    603296
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        CG5110 - Dsor1
        pull down, autoradiography
        (Mouchel-Vielh et al., 2008)
        CG5110 - corto
        two hybrid, pull down, western blot
        (Mouchel-Vielh et al., 2011)
        CG5110 - rl
        pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot
        (Mouchel-Vielh et al., 2011, Mouchel-Vielh et al., 2008)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        CG5110
        enhanceable
        corto
        (Mouchel-Vielh et al., 2011)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Subunit Structure (UniProtKB)
        Part of the Ragulator complex composed of CG5110, CG5189, CG14184, CG14812, and CG14977.
        (UniProt, Q9VJD2 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map

        2-53

        Cytogenetic map
        36C10-36C10
        Sequence location
        2L:17,481,231..17,482,037 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        36C10-36C10
        Limits computationally determined from genome sequence between P{lacW}Aac11k06710 and P{EP}CG10413EP2164
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-53

        (FlyBase, 2016)

        2-52.7

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (3)
        Genomic Clones (17)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (61)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Mouchel-Vielh et al., 2008)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of

            Source for merge of: CG5110 BcDNA:RE09173

            (FlyBase, 1996-)
            Additional comments

            Source for merge of CG5110 BcDNA:RE09173 was TrEMBL update ( date:020807 ).

            (FlyBase, 1996-)
            Other Comments
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 39 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (4)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (30)