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Gene Dmel\CG5131

General Information
Symbol	Dmel\CG5131	Species	D. melanogaster
Name		Annotation symbol	CG5131
Feature type	protein_coding_gene	FlyBase ID	FBgn0032644
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	36C10-36C10	Sequence location	2L:17,484,518..17,485,624 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5131 (FBgn0032644). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: KU70 binding. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase M76, ATP23. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult hindgut, adult heart, adult fat body, adult salivary gland, adult female reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638410_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5131. Gene sequence location is 2L:17484518..17485624.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features BKN20353 HFA02817
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36C10-36C10   Limits computationally determined from genome sequence between P{lacW}Aac11k06710 and P{EP}CG10413EP2164
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5131 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5131-RA FBtr0080984  NM_136001   1034   283
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5131-PA   FBpp0080537   31.9   283   7.09     NP_609845   AAF53622
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M76, ATP23 (IPR019165)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA941357   AE014134 AAF53622   AI258684   AI519726   AI543822   AY118981 AAM50841   BX027401   BX042864   BX054431   BX067348   CL868558   CO337042   EC261504   GH946060   GH950466   GH955425   GH961053   GH967382   GH978670   GH983166   GH984775
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VJD0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032644    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032644 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032644 expression level Developmental Stage   Expression Level embryo 00-02hr    2460 embryo 02-04hr    1679 embryo 04-06hr    1365 embryo 06-08hr    1141 embryo 08-10hr    1380 embryo 10-12hr    1900 embryo 12-14hr    1389 embryo 14-16hr    2036 embryo 16-18hr    2037 embryo 18-20hr    1516 embryo 20-22hr    1287 embryo 22-24hr    1272 larva L1    2055 larva L2    2344 larva L3 12hr old    1491 larva L3 puffstage 1-2    645 larva L3 puffstage 3-6    583 larva L3 puffstage 7-9    666 white prepupae new    643 white prepupae 12hr    642 white prepupae 24hr    829 pupae 2d postWPP    1329 pupae 3d postWPP    2315 pupae 4d postWPP    822 adult male 01day    779 adult male 05day    734 adult male 30day    770 adult female 01day    1520 adult female 05day    1846 adult female 30day    1968 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2460) embryo 02-04hr  (1679) embryo 04-06hr  (1365) embryo 06-08hr  (1141) embryo 08-10hr  (1380) embryo 10-12hr  (1900) embryo 12-14hr  (1389) embryo 14-16hr  (2036) embryo 16-18hr  (2037) embryo 18-20hr  (1516) embryo 20-22hr  (1287) embryo 22-24hr  (1272) larva L1  (2055) larva L2  (2344) larva L3 12hr old  (1491) larva L3 puffstage 1-2  (645) larva L3 puffstage 3-6  (583) larva L3 puffstage 7-9  (666) white prepupae new  (643) white prepupae 12hr  (642) white prepupae 24hr  (829) pupae 2d postWPP  (1329) pupae 3d postWPP  (2315) pupae 4d postWPP  (822) adult male 01day  (779) adult male 05day  (734) adult male 30day  (770) adult female 01day  (1520) adult female 05day  (1846) adult female 30day  (1968) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2460) embryo 02-04hr  (1679) embryo 04-06hr    1365 embryo 06-08hr    1141 embryo 08-10hr    1380 embryo 10-12hr  (1900) embryo 12-14hr    1389 embryo 14-16hr  (2036) embryo 16-18hr  (2037) embryo 18-20hr  (1516) embryo 20-22hr    1287 embryo 22-24hr    1272 larva L1  (2055) larva L2  (2344) larva L3 12hr old  1491 larva L3 puffstage 1-2    645 larva L3 puffstage 3-6    583 larva L3 puffstage 7-9    666 white prepupae new    643 white prepupae 12hr    642 white prepupae 24hr    829 pupae 2d postWPP    1329 pupae 3d postWPP  (2315) pupae 4d postWPP    822 adult male 01day    779 adult male 05day    734 adult male 30day    770 adult female 01day  (1520) adult female 05day  (1846) adult female 30day  (1968) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2460 embryo 02-04hr    1679 embryo 04-06hr    1365 embryo 06-08hr    1141 embryo 08-10hr    1380 embryo 10-12hr    1900 embryo 12-14hr    1389 embryo 14-16hr    2036 embryo 16-18hr    2037 embryo 18-20hr    1516 embryo 20-22hr    1287 embryo 22-24hr    1272 larva L1    2055 larva L2    2344 larva L3 12hr old    1491 larva L3 puffstage 1-2    645 larva L3 puffstage 3-6    583 larva L3 puffstage 7-9    666 white prepupae new    643 white prepupae 12hr    642 white prepupae 24hr    829 pupae 2d postWPP    1329 pupae 3d postWPP    2315 pupae 4d postWPP    822 adult male 01day    779 adult male 05day    734 adult male 30day    770 adult female 01day    1520 adult female 05day    1846 adult female 30day    1968 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2460 embryo 02-04hr    1679 embryo 04-06hr    1365 embryo 06-08hr    1141 embryo 08-10hr    1380 embryo 10-12hr    1900 embryo 12-14hr    1389 embryo 14-16hr    2036 embryo 16-18hr    2037 embryo 18-20hr    1516 embryo 20-22hr    1287 embryo 22-24hr    1272 larva L1    2055 larva L2    2344 larva L3 12hr old    1491 larva L3 puffstage 1-2    645 larva L3 puffstage 3-6    583 larva L3 puffstage 7-9    666 white prepupae new    643 white prepupae 12hr    642 white prepupae 24hr    829 pupae 2d postWPP    1329 pupae 3d postWPP    2315 pupae 4d postWPP    822 adult male 01day    779 adult male 05day    734 adult male 30day    770 adult female 01day    1520 adult female 05day    1846 adult female 30day    1968 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032644 expression level Developmental Stage   Expression Level embryo 00-02hr    2460 embryo 02-04hr    1679 embryo 04-06hr    1365 embryo 06-08hr    1141 embryo 08-10hr    1380 embryo 10-12hr    1900 embryo 12-14hr    1389 embryo 14-16hr    2036 embryo 16-18hr    2037 embryo 18-20hr    1516 embryo 20-22hr    1287 embryo 22-24hr    1272 larva L1    2055 larva L2    2344 larva L3 12hr old    1491 larva L3 puffstage 1-2    645 larva L3 puffstage 3-6    583 larva L3 puffstage 7-9    666 white prepupae new    643 white prepupae 12hr    642 white prepupae 24hr    829 pupae 2d postWPP    1329 pupae 3d postWPP    2315 pupae 4d postWPP    822 adult male 01day    779 adult male 05day    734 adult male 30day    770 adult female 01day    1520 adult female 05day    1846 adult female 30day    1968 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2460) embryo 02-04hr  (1679) embryo 04-06hr  (1365) embryo 06-08hr  (1141) embryo 08-10hr  (1380) embryo 10-12hr  (1900) embryo 12-14hr  (1389) embryo 14-16hr  (2036) embryo 16-18hr  (2037) embryo 18-20hr  (1516) embryo 20-22hr  (1287) embryo 22-24hr  (1272) larva L1  (2055) larva L2  (2344) larva L3 12hr old  (1491) larva L3 puffstage 1-2  (645) larva L3 puffstage 3-6  (583) larva L3 puffstage 7-9  (666) white prepupae new  (643) white prepupae 12hr  (642) white prepupae 24hr  (829) pupae 2d postWPP  (1329) pupae 3d postWPP  (2315) pupae 4d postWPP  (822) adult male 01day  (779) adult male 05day  (734) adult male 30day  (770) adult female 01day  (1520) adult female 05day  (1846) adult female 30day  (1968) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2460 embryo 02-04hr  1679 embryo 04-06hr    1365 embryo 06-08hr    1141 embryo 08-10hr    1380 embryo 10-12hr  1900 embryo 12-14hr    1389 embryo 14-16hr  2036 embryo 16-18hr  2037 embryo 18-20hr  1516 embryo 20-22hr    1287 embryo 22-24hr    1272 larva L1  2055 larva L2  2344 larva L3 12hr old  1491 larva L3 puffstage 1-2    645 larva L3 puffstage 3-6    583 larva L3 puffstage 7-9    666 white prepupae new    643 white prepupae 12hr    642 white prepupae 24hr    829 pupae 2d postWPP    1329 pupae 3d postWPP  2315 pupae 4d postWPP    822 adult male 01day    779 adult male 05day    734 adult male 30day    770 adult female 01day  1520 adult female 05day  1846 adult female 30day  1968 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2460 embryo 02-04hr    1679 embryo 04-06hr    1365 embryo 06-08hr    1141 embryo 08-10hr    1380 embryo 10-12hr    1900 embryo 12-14hr    1389 embryo 14-16hr    2036 embryo 16-18hr    2037 embryo 18-20hr    1516 embryo 20-22hr    1287 embryo 22-24hr    1272 larva L1    2055 larva L2    2344 larva L3 12hr old    1491 larva L3 puffstage 1-2    645 larva L3 puffstage 3-6    583 larva L3 puffstage 7-9    666 white prepupae new    643 white prepupae 12hr    642 white prepupae 24hr    829 pupae 2d postWPP    1329 pupae 3d postWPP    2315 pupae 4d postWPP    822 adult male 01day    779 adult male 05day    734 adult male 30day    770 adult female 01day    1520 adult female 05day    1846 adult female 30day    1968 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2460 embryo 02-04hr    1679 embryo 04-06hr    1365 embryo 06-08hr    1141 embryo 08-10hr    1380 embryo 10-12hr    1900 embryo 12-14hr    1389 embryo 14-16hr    2036 embryo 16-18hr    2037 embryo 18-20hr    1516 embryo 20-22hr    1287 embryo 22-24hr    1272 larva L1    2055 larva L2    2344 larva L3 12hr old    1491 larva L3 puffstage 1-2    645 larva L3 puffstage 3-6    583 larva L3 puffstage 7-9    666 white prepupae new    643 white prepupae 12hr    642 white prepupae 24hr    829 pupae 2d postWPP    1329 pupae 3d postWPP    2315 pupae 4d postWPP    822 adult male 01day    779 adult male 05day    734 adult male 30day    770 adult female 01day    1520 adult female 05day    1846 adult female 30day    1968 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032644    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032644 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult hindgut, adult heart, adult fat body, adult salivary gland, adult female reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032644 expression level Tissue   Expression Level Larval Central Nervous System    125.975 Larval Midgut    76.9 Larval Hindgut    111.1 Larval Malpighian Tubules    88.1 Larval Fat Body    71.7 Larval Salivary Gland    87.8 Larval Trachea    95.175 Larval Carcass    103.925 Adult Head    88.8 Adult Eye    77.125 Adult Brain    116.3 Adult Thoracic-Abdominal Ganglion    136.6 Adult Crop    115.6 Adult Midgut    91.7 Adult Hindgut    123.4 Adult Malpighian Tubules    90.5 Adult Fat Body    121.6 Adult Salivary Gland    121.7 Adult Heart    123.05 Adult VirginFemale Spermatheca    126.6 Adult InseminatedFemale Spermatheca    121.4 Adult Ovary    242.5 Adult Testis    34.2 Adult Male Accessory Gland    96.9 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    125.975 Larval Midgut    76.9 Larval Hindgut    111.1 Larval Malpighian Tubules    88.1 Larval Fat Body    71.7 Larval Salivary Gland    87.8 Larval Trachea    95.175 Larval Carcass    103.925 Adult Head    88.8 Adult Eye    77.125 Adult Brain    116.3 Adult Thoracic-Abdominal Ganglion    136.6 Adult Crop    115.6 Adult Midgut    91.7 Adult Hindgut    123.4 Adult Malpighian Tubules    90.5 Adult Fat Body    121.6 Adult Salivary Gland    121.7 Adult Heart    123.05 Adult VirginFemale Spermatheca    126.6 Adult InseminatedFemale Spermatheca    121.4 Adult Ovary    242.5 Adult Testis    34.2 Adult Male Accessory Gland    96.9 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    125.975 Larval Midgut    76.9 Larval Hindgut    111.1 Larval Malpighian Tubules    88.1 Larval Fat Body    71.7 Larval Salivary Gland    87.8 Larval Trachea    95.175 Larval Carcass    103.925 Adult Head    88.8 Adult Eye    77.125 Adult Brain    116.3 Adult Thoracic-Abdominal Ganglion    136.6 Adult Crop    115.6 Adult Midgut    91.7 Adult Hindgut    123.4 Adult Malpighian Tubules    90.5 Adult Fat Body    121.6 Adult Salivary Gland    121.7 Adult Heart    123.05 Adult VirginFemale Spermatheca    126.6 Adult InseminatedFemale Spermatheca    121.4 Adult Ovary    242.5 Adult Testis    34.2 Adult Male Accessory Gland    96.9 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    125.975 Larval Midgut    76.9 Larval Hindgut    111.1 Larval Malpighian Tubules    88.1 Larval Fat Body    71.7 Larval Salivary Gland    87.8 Larval Trachea    95.175 Larval Carcass    103.925 Adult Head    88.8 Adult Eye    77.125 Adult Brain    116.3 Adult Thoracic-Abdominal Ganglion    136.6 Adult Crop    115.6 Adult Midgut    91.7 Adult Hindgut    123.4 Adult Malpighian Tubules    90.5 Adult Fat Body    121.6 Adult Salivary Gland    121.7 Adult Heart    123.05 Adult VirginFemale Spermatheca    126.6 Adult InseminatedFemale Spermatheca    121.4 Adult Ovary    242.5 Adult Testis    34.2 Adult Male Accessory Gland    96.9 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032644 expression level Tissue   Expression Level Larval Central Nervous System    125.975 Larval Midgut    76.9 Larval Hindgut    111.1 Larval Malpighian Tubules    88.1 Larval Fat Body    71.7 Larval Salivary Gland    87.8 Larval Trachea    95.175 Larval Carcass    103.925 Adult Head    88.8 Adult Eye    77.125 Adult Brain    116.3 Adult Thoracic-Abdominal Ganglion    136.6 Adult Crop    115.6 Adult Midgut    91.7 Adult Hindgut    123.4 Adult Malpighian Tubules    90.5 Adult Fat Body    121.6 Adult Salivary Gland    121.7 Adult Heart    123.05 Adult VirginFemale Spermatheca    126.6 Adult InseminatedFemale Spermatheca    121.4 Adult Ovary    242.5 Adult Testis    34.2 Adult Male Accessory Gland    96.9 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    125.975 Larval Midgut    76.9 Larval Hindgut    111.1 Larval Malpighian Tubules    88.1 Larval Fat Body    71.7 Larval Salivary Gland    87.8 Larval Trachea    95.175 Larval Carcass    103.925 Adult Head    88.8 Adult Eye    77.125 Adult Brain    116.3 Adult Thoracic-Abdominal Ganglion    136.6 Adult Crop    115.6 Adult Midgut    91.7 Adult Hindgut    123.4 Adult Malpighian Tubules    90.5 Adult Fat Body    121.6 Adult Salivary Gland    121.7 Adult Heart    123.05 Adult VirginFemale Spermatheca    126.6 Adult InseminatedFemale Spermatheca    121.4 Adult Ovary    242.5 Adult Testis    34.2 Adult Male Accessory Gland    96.9 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    125.975 Larval Midgut    76.9 Larval Hindgut    111.1 Larval Malpighian Tubules    88.1 Larval Fat Body    71.7 Larval Salivary Gland    87.8 Larval Trachea    95.175 Larval Carcass    103.925 Adult Head    88.8 Adult Eye    77.125 Adult Brain    116.3 Adult Thoracic-Abdominal Ganglion    136.6 Adult Crop    115.6 Adult Midgut    91.7 Adult Hindgut    123.4 Adult Malpighian Tubules    90.5 Adult Fat Body    121.6 Adult Salivary Gland    121.7 Adult Heart    123.05 Adult VirginFemale Spermatheca    126.6 Adult InseminatedFemale Spermatheca    121.4 Adult Ovary    242.5 Adult Testis    34.2 Adult Male Accessory Gland    96.9 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    125.975 Larval Midgut    76.9 Larval Hindgut    111.1 Larval Malpighian Tubules    88.1 Larval Fat Body    71.7 Larval Salivary Gland    87.8 Larval Trachea    95.175 Larval Carcass    103.925 Adult Head    88.8 Adult Eye    77.125 Adult Brain    116.3 Adult Thoracic-Abdominal Ganglion    136.6 Adult Crop    115.6 Adult Midgut    91.7 Adult Hindgut    123.4 Adult Malpighian Tubules    90.5 Adult Fat Body    121.6 Adult Salivary Gland    121.7 Adult Heart    123.05 Adult VirginFemale Spermatheca    126.6 Adult InseminatedFemale Spermatheca    121.4 Adult Ovary    242.5 Adult Testis    34.2 Adult Male Accessory Gland    96.9 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    88.8   NA  Eye    77.125   NA  Brain    116.3   125.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    136.6   NA  Crop    115.6   76.9  Midgut    91.7   111.1  Hindgut    123.4   88.1  Malpighian Tubules    90.5   71.7  Fat Body    121.6   87.8  Salivary Gland    121.7   NA  Heart    123.05   95.175  Trachea    NA   NA  VirginFemale Spermatheca    126.6   NA  InseminatedFemale Spermatheca    121.4   NA  Ovary    242.5   NA  Testis    34.2   NA  Male Accessory Gland    96.9   103.925  Carcass    106.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_19
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032644 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5131-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG5131EY12407 viable, with Scer\GAL4pnr-MD237 CG5131GD11548 Sterility Allele fertile CG5131EY12407 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG5131 Class Mutagen Stocks Known lesion CG5131EY12407 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5131 Class Mutagen Stocks Known lesion CG5131GD11548 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5131KK100257 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7068 (Ryder, 2004.4.26) Df(2L)Exel7069 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11548} NA P{KK100257} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG5131EY12407 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
KU70 binding inferred from sequence or structural similarity with EMBL:AF078164 (FlyBase, 1992-) metalloendopeptidase activity inferred from electronic annotation with InterPro:IPR019165 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5131 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0032644 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35057
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14800 Dere\GG21092 Dgri\GH11623 Dmoj\GI17926 Dper\GL14503 Dpse\GA18681 Dsec\GM17243 Dsim\GD12032 Dvir\GJ17699 Dwil\GK18160 Dyak\GE12797
Curated drosophilid orthologs	Dpse\GA18681
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000332-PA Aedes aegypti (mosquito) AGAP009567-PA Anopheles gambiae (mosquito) XP_001949777.1 Acyrthosiphon pisum (pea aphid) At3g03420.1 Arabidopsis thaliana (wall cress) 8492 Batrachochytrium dendrobatidis (chytrid fungus) 132353 Branchiostoma floridae (lancelet) BGIBMGA006761-PA Bombyx mori (silk worm) ENSBTAP00000042356 Bos taurus (bovine) CAL0006273 Candida albicans (a form of yeast) ENSCAFP00000000429 Canis familiaris (dog) CAGL0M10593g Candida glabrata (haploid yeast) CMA132C Cyanidioschyzon merolae (red alga) cn05345 Cryptococcus neoformans (yeast-like fungus) CPIJ004694 Culex pipens (mosquito) ENSCPOP00000013359 Cavia porcellus (guinea pig) 110443 Capitella spl (polychaete worm) DDB0201962 Dictyostelium discoideum (amoeba) DEHA2F24200g Debaryomyces Hansenii (yeast) 330661 Daphnia pulex (daphnia) ENSDARP00000087721 Danio rerio (zebra fish) ENSECAP00000017318 Equus caballus (horse) ENSGACP00000025273 Gymnopilus aculeatus (mushroom) ENSGALP00000015845 Gallus gallus (chicken) 192056 Hypsipyla robusta (cedar shoot borer) ENSP00000300145 Homo sapiens (human) ISCW023892-PA Ixodes scapularis (deer tick) KLLA0C09130g Kluyveromyces lactis (yeast) LmjF36.1690 Leishmania major (virus) 30281 Monocosta brevicollis (choanoflagellate) ENSMODP00000026686 Monodelphis domestica (gray opossum) ENSMMUP00000025255 Macaca mulatta (rhesus monkey) 124990 Nematostella vectensis (starlet anemone) XP_001606467.1 Nasonia vitripennis (wasp) ENSOANP00000019598 Ornithorynchus anatinus (platypus) LOC_Os12g19090.1 Oryza sativa (asian rice) 22147 Ostreococcus tauri (green alga) PF14_0396 Plasmodium falciparum (protozoal parasite) PHUM001266-PA Pediculus humanus (human body louse) 153750 Physcomitrella patens (moss) ENSPPYP00000005369 Pongo pygmaeus (orangutan) 174134 Populus trichocarpa (black cottonwood) ENSPTRP00000008771 Pan troglodytes (chimpanzee) YNR020C Saccharomyces cerevisiae (budding yeast) SPCC320.12 Schizosaccharomyces pombe (fission yeast) XP_001195434.1 Strongylocentrotus purpuratus (purple sea urchin) 63972 Trichoplax adhaerens (metazoa) XP_971269.1 Tribolium castaneum (red flour beetle) ENSTNIP00000009706 Tetraodon nigroviridis (green spotted pufferfish) 260799 Thalassiosira pseudonana (marine diatom) ENSTRUP00000020682 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000032154 Xenopus tropicalis (frog) YALI0F10769g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14011 LH14646 ISCW023892 FBgn0230518 FBgn0220159 FBgn0204868 FBgn0183771 FBgn0172154 JGI_V11_330661 FBgn0078681 FBgn0152108 FBgn0140667 FBgn0119103 FBgn0113275 FBgn0091827 CPIJ004694 BGIBMGA006761 ACYPI008652 GB12965 AGAP009567 AAEL000332 PB19913 PHUM354870 GLEAN_03033
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	20738 y1 w67c23; P{EPgy2}CG5131EY12407
VDRC	v106916 P{KK100257}VIE-260B v42025 w1118 P{GD11548}v42025
Genomic Clones ( 1 )
	BACR07M13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP01932
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD25463 LD38987 LD39434
Other clones	562100 EN13717 RP004097465 RP004136518 RP004169658 RP004212444 RP004222373 RP004257397 RP004467878 RP004538423
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032644 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35057
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136001 RefSeq (Proteins) • NP_609845 DDBJ / EMBL / GenBank • AAF53622 AAM50841 AI258684 AY118981 CL868558 Entrez Gene - A searchable database of RefSeq genes. • 35057 UniProtKB/TrEMBL • Q9VJD0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M76, ATP23 (IPR019165)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0032644 DRSC - Results from RNAi screens. • FBgn0032644 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032644 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5131-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032644 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35057 InParanoid A subset of ortholog calls from InParanoid. • AAEL000332-PA Aedes aegypti (mosquito) AGAP009567-PA Anopheles gambiae (mosquito) XP_001949777.1 Acyrthosiphon pisum (pea aphid) At3g03420.1 Arabidopsis thaliana (wall cress) 8492 Batrachochytrium dendrobatidis (chytrid fungus) 132353 Branchiostoma floridae (lancelet) BGIBMGA006761-PA Bombyx mori (silk worm) ENSBTAP00000042356 Bos taurus (bovine) CAL0006273 Candida albicans (a form of yeast) ENSCAFP00000000429 Canis familiaris (dog) CAGL0M10593g Candida glabrata (haploid yeast) CMA132C Cyanidioschyzon merolae (red alga) cn05345 Cryptococcus neoformans (yeast-like fungus) CPIJ004694 Culex pipens (mosquito) ENSCPOP00000013359 Cavia porcellus (guinea pig) 110443 Capitella spl (polychaete worm) DDB0201962 Dictyostelium discoideum (amoeba) DEHA2F24200g Debaryomyces Hansenii (yeast) 330661 Daphnia pulex (daphnia) ENSDARP00000087721 Danio rerio (zebra fish) ENSECAP00000017318 Equus caballus (horse) ENSGACP00000025273 Gymnopilus aculeatus (mushroom) ENSGALP00000015845 Gallus gallus (chicken) 192056 Hypsipyla robusta (cedar shoot borer) ENSP00000300145 Homo sapiens (human) ISCW023892-PA Ixodes scapularis (deer tick) KLLA0C09130g Kluyveromyces lactis (yeast) LmjF36.1690 Leishmania major (virus) 30281 Monocosta brevicollis (choanoflagellate) ENSMODP00000026686 Monodelphis domestica (gray opossum) ENSMMUP00000025255 Macaca mulatta (rhesus monkey) 124990 Nematostella vectensis (starlet anemone) XP_001606467.1 Nasonia vitripennis (wasp) ENSOANP00000019598 Ornithorynchus anatinus (platypus) LOC_Os12g19090.1 Oryza sativa (asian rice) 22147 Ostreococcus tauri (green alga) PF14_0396 Plasmodium falciparum (protozoal parasite) PHUM001266-PA Pediculus humanus (human body louse) 153750 Physcomitrella patens (moss) ENSPPYP00000005369 Pongo pygmaeus (orangutan) 174134 Populus trichocarpa (black cottonwood) ENSPTRP00000008771 Pan troglodytes (chimpanzee) YNR020C Saccharomyces cerevisiae (budding yeast) SPCC320.12 Schizosaccharomyces pombe (fission yeast) XP_001195434.1 Strongylocentrotus purpuratus (purple sea urchin) 63972 Trichoplax adhaerens (metazoa) XP_971269.1 Tribolium castaneum (red flour beetle) ENSTNIP00000009706 Tetraodon nigroviridis (green spotted pufferfish) 260799 Thalassiosira pseudonana (marine diatom) ENSTRUP00000020682 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000032154 Xenopus tropicalis (frog) YALI0F10769g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35057 modMine - Data generated by the modENCODE project. • FBgn0032644 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14011 LH14646 ISCW023892 FBgn0230518 FBgn0220159 FBgn0204868 FBgn0183771 FBgn0172154 JGI_V11_330661 FBgn0078681 FBgn0152108 FBgn0140667 FBgn0119103 FBgn0113275 FBgn0091827 CPIJ004694 BGIBMGA006761 ACYPI008652 GB12965 AGAP009567 AAEL000332 PB19913 PHUM354870 GLEAN_03033
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG5131 (Keleman et al., 2009.8.5, Cammarato et al., 2011)
Name Synonym
Secondary FlyBase IDs
References ( 13 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]