FB2021_01, released Feb 18, 2021

Gene: Dmel\CG10343

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General Information
Symbol
Dmel\CG10343
Species
D. melanogaster
Name
Annotation Symbol
CG10343
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032703
Gene Model Status
Current
Stock Availability
3 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
37A1-37A1
Sequence location
2L:18,703,473..18,704,454 [+]
Recombination map

2-54

RefSeq locus
NT_033779 REGION:18703473..18704454
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (0 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG10343 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG10343-RA
FBtr0081098
NM_136056
843
214
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG10343-PA
FBpp0080648
24.1
214
4.43
NP_609900
AAF53695
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG10343 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG10343 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG10343
Transgenic constructs containing regulatory region of CG10343
Aberrations (Deficiencies and Duplications) ( 2 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RWDD4
14 of 15
Yes
Yes
Hsap\RWDD1
1 of 15
No
No
Hsap\RWDD4P2
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rwdd4a
13 of 15
Yes
Yes
Mmus\Rwdd1
1 of 15
No
No
Rattus norvegicus (Norway rat) (2)
Rnor\Rwdd4
13 of 13
Yes
Yes
Rnor\Rwdd1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\rwdd4
9 of 12
Yes
Yes
Xtro\rwdd1
1 of 12
No
No
Danio rerio (Zebrafish) (2)
Drer\rwdd
10 of 15
Yes
Yes
Drer\rwdd1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\impt-1
1 of 15
Yes
Yes
Cele\T26E3.4
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (1)
Atha\AT1G51730
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\GIR2
2 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPCC1393.09c
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190FYG )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001203
Drosophila simulans
Dsim\GD24152
Drosophila sechellia
Dsec\GM17289
Drosophila erecta
Dere\GG21128
Drosophila yakuba
Dyak\GE13202
Drosophila ananassae
Dana\GF15069
Drosophila pseudoobscura pseudoobscura
Dpse\GA10259
Drosophila persimilis
Dper\GL19632
Drosophila willistoni
Dwil\GK24690
Drosophila virilis
Dvir\GJ17683
Drosophila mojavensis
Dmoj\GI17912
Drosophila grimshawi
Dgri\GH11608
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150DR2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018802
Glossina morsitans
Tsetse fly
Gmor\GMOY008947
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14286
Mayetiola destructor
Hessian fly
Mdes\Mdes016099
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006654
Anopheles darlingi
American malaria mosquito
Adar\ADAC001485
Anopheles gambiae
Malaria mosquito
Agam\AGAP010019
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005316
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0GQZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006658
Danaus plexippus
Monarch butterfly
Dple\DPOGS209598-PA
Apis florea
Little honeybee
Aflo\2620475284
Apis mellifera
Western honey bee
Amel\LOC410964
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13881
Bombus terrestris
Buff-tailed bumblebee
Bter\15215311
Linepithema humile
Argentine ant
Lhum\LH14830
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001b6a
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07846
Tribolium castaneum
Red flour beetle
Tcas\TC012817
Pediculus humanus
Human body louse
Phum\PHUM467560
Rhodnius prolixus
Kissing bug
Rpro\RPRC006437
Cimex lectularius
Bed bug
Clec\CLEC004135
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001987
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07532
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0GRT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007783
Ixodes scapularis
Black-legged tick
Isca\ISCW022933
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80378.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304240
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0R0A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rwdd4a
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020462
Gallus gallus
Domestic chicken
Ggal\RWDD4
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG5515
1 of 10
CG15605
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RWDD4; RWD domain containing 4
    14 of 15
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        CG10343 - rictor
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map

        2-54

        Cytogenetic map
        37A1-37A1
        Sequence location
        2L:18,703,473..18,704,454 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        37A1-37A1
        Limits computationally determined from genome sequence between P{EP}CG10413EP2164 and P{lacW}l(2)37Dbk16106&P{lacW}Catsupk05424
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-54

        (FlyBase, 2016)

        2-53.4

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (3)
        Genomic Clones (19)
        cDNA Clones (17)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of

          Source for merge of: CG10343 anon-WO0118547.123

          (FlyBase, 1996-)
          Additional comments

          Source for merge of CG10343 anon-WO0118547.123 was sequence comparison ( date:051113 ).

          (FlyBase, 1996-)
          Other Comments

          Area matching Drosophila ESTs AA696743 and AA803977.

          (Davies, 2001.3.15)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 34 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Synonyms and Secondary IDs (2)
          Reported As
          Symbol Synonym
          CG10343
          (Hosono et al., 2015, Daneshvar et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Isogai et al., 2007)
          anon-WO0118547.123
          Name Synonyms
          Secondary FlyBase IDs
          • FBgn0062230
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (25)