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Gene Dmel\Jwa

General Information
Symbol	Dmel\Jwa	Species	D. melanogaster
Name	Jwa ortholog	Annotation symbol	CG10373
Feature type	protein_coding_gene	FlyBase ID	FBgn0032704
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	37A1-37A1	Sequence location	2L:18,704,570..18,705,699 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Jwa ortholog is referred to in FlyBase by the symbol Dmel\Jwa (CG10373, FBgn0032704). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: ion channel activity. There is experimental evidence that it is involved in the biological process: response to ethanol. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Chloride channel, core; Prenylated rab acceptor PRA1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult fat body, adult female reproductive system, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637881_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG10373. Gene sequence location is 2L:18704570..18705699.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features HFA02048 BKN20782
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37A1-37A1   Limits computationally determined from genome sequence between P{EP}CG10413EP2164 and P{lacW}l(2)37Dbk16106&P{lacW}Catsupk05424
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Jwa for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Unconventional translation start (UUG) postulated; FBrf0200346, FlyBase analysis. gene_with_non_canonical_start_codon ; SO:0001739
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Jwa-RA FBtr0081127  NM_136057   1130   249
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Jwa-PA   FBpp0080671   27.8   249   10.55     NP_609901   AAF53696
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Prenylated rab acceptor PRA1 (IPR004895) Chloride channel, core (IPR014743)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA802296   AA803750   AE014134 AAF53696   AI107942   AI259483   AI259494   AI293679   AI402576   AI403503   AI517142   AW940211   AY094678 AAM11031   BG637612   BI229722   BI234264   BI235087   BI364161   BI365748   BI373164   BI636096   BI637619   BT132652   CA803864   CO155999   CO193538   CO194936   CO262201   CO266240   CO269576   CO294801   CO323331   CO335845   CO336242   CO337441   EC061535   EC071876   EC074590   EC196583   EC212671   EC220722   EC243270   EC245326   EC261371   EC263942   EC265195   EC267776   FE862881   FE862935   FE863124   FE863354   FE863383   FE863398   FE863426   GH742407   GH767888   GH768190
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SXD0 Q9VJ59
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032704    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032704 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032704 expression level Developmental Stage   Expression Level embryo 00-02hr    6182 embryo 02-04hr    2507 embryo 04-06hr    1273 embryo 06-08hr    2094 embryo 08-10hr    2963 embryo 10-12hr    3742 embryo 12-14hr    3373 embryo 14-16hr    2550 embryo 16-18hr    3423 embryo 18-20hr    3112 embryo 20-22hr    3704 embryo 22-24hr    4078 larva L1    5140 larva L2    7591 larva L3 12hr old    7190 larva L3 puffstage 1-2    8187 larva L3 puffstage 3-6    7977 larva L3 puffstage 7-9    9062 white prepupae new    7255 white prepupae 12hr    4777 white prepupae 24hr    4230 pupae 2d postWPP    4319 pupae 3d postWPP    4116 pupae 4d postWPP    2917 adult male 01day    4111 adult male 05day    4364 adult male 30day    4395 adult female 01day    4307 adult female 05day    6367 adult female 30day    6491 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6182) embryo 02-04hr  (2507) embryo 04-06hr  (1273) embryo 06-08hr  (2094) embryo 08-10hr  (2963) embryo 10-12hr  (3742) embryo 12-14hr  (3373) embryo 14-16hr  (2550) embryo 16-18hr  (3423) embryo 18-20hr  (3112) embryo 20-22hr  (3704) embryo 22-24hr  (4078) larva L1  (5140) larva L2  (7591) larva L3 12hr old  (7190) larva L3 puffstage 1-2  (8187) larva L3 puffstage 3-6  (7977) larva L3 puffstage 7-9  (9062) white prepupae new  (7255) white prepupae 12hr  (4777) white prepupae 24hr  (4230) pupae 2d postWPP  (4319) pupae 3d postWPP  (4116) pupae 4d postWPP  (2917) adult male 01day  (4111) adult male 05day  (4364) adult male 30day  (4395) adult female 01day  (4307) adult female 05day  (6367) adult female 30day  (6491) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6182) embryo 02-04hr  (2507) embryo 04-06hr    1273 embryo 06-08hr  (2094) embryo 08-10hr  (2963) embryo 10-12hr  (3742) embryo 12-14hr  (3373) embryo 14-16hr  (2550) embryo 16-18hr  (3423) embryo 18-20hr  (3112) embryo 20-22hr  (3704) embryo 22-24hr  (4078) larva L1  (5140) larva L2  (7591) larva L3 12hr old  (7190) larva L3 puffstage 1-2  (8187) larva L3 puffstage 3-6  (7977) larva L3 puffstage 7-9  (9062) white prepupae new  (7255) white prepupae 12hr  (4777) white prepupae 24hr  (4230) pupae 2d postWPP  (4319) pupae 3d postWPP  (4116) pupae 4d postWPP  (2917) adult male 01day  (4111) adult male 05day  (4364) adult male 30day  (4395) adult female 01day  (4307) adult female 05day  (6367) adult female 30day  (6491) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6182 embryo 02-04hr    2507 embryo 04-06hr    1273 embryo 06-08hr    2094 embryo 08-10hr    2963 embryo 10-12hr    3742 embryo 12-14hr    3373 embryo 14-16hr    2550 embryo 16-18hr    3423 embryo 18-20hr    3112 embryo 20-22hr    3704 embryo 22-24hr    4078 larva L1    5140 larva L2    7591 larva L3 12hr old    7190 larva L3 puffstage 1-2    8187 larva L3 puffstage 3-6    7977 larva L3 puffstage 7-9    9062 white prepupae new    7255 white prepupae 12hr    4777 white prepupae 24hr    4230 pupae 2d postWPP    4319 pupae 3d postWPP    4116 pupae 4d postWPP    2917 adult male 01day    4111 adult male 05day    4364 adult male 30day    4395 adult female 01day    4307 adult female 05day    6367 adult female 30day    6491 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6182 embryo 02-04hr    2507 embryo 04-06hr    1273 embryo 06-08hr    2094 embryo 08-10hr    2963 embryo 10-12hr    3742 embryo 12-14hr    3373 embryo 14-16hr    2550 embryo 16-18hr    3423 embryo 18-20hr    3112 embryo 20-22hr    3704 embryo 22-24hr    4078 larva L1    5140 larva L2    7591 larva L3 12hr old    7190 larva L3 puffstage 1-2    8187 larva L3 puffstage 3-6    7977 larva L3 puffstage 7-9    9062 white prepupae new    7255 white prepupae 12hr    4777 white prepupae 24hr    4230 pupae 2d postWPP    4319 pupae 3d postWPP    4116 pupae 4d postWPP    2917 adult male 01day    4111 adult male 05day    4364 adult male 30day    4395 adult female 01day    4307 adult female 05day    6367 adult female 30day    6491 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032704 expression level Developmental Stage   Expression Level embryo 00-02hr    6182 embryo 02-04hr    2507 embryo 04-06hr    1273 embryo 06-08hr    2094 embryo 08-10hr    2963 embryo 10-12hr    3742 embryo 12-14hr    3373 embryo 14-16hr    2550 embryo 16-18hr    3423 embryo 18-20hr    3112 embryo 20-22hr    3704 embryo 22-24hr    4078 larva L1    5140 larva L2    7591 larva L3 12hr old    7190 larva L3 puffstage 1-2    8187 larva L3 puffstage 3-6    7977 larva L3 puffstage 7-9    9062 white prepupae new    7255 white prepupae 12hr    4777 white prepupae 24hr    4230 pupae 2d postWPP    4319 pupae 3d postWPP    4116 pupae 4d postWPP    2917 adult male 01day    4111 adult male 05day    4364 adult male 30day    4395 adult female 01day    4307 adult female 05day    6367 adult female 30day    6491 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6182) embryo 02-04hr  (2507) embryo 04-06hr  (1273) embryo 06-08hr  (2094) embryo 08-10hr  (2963) embryo 10-12hr  (3742) embryo 12-14hr  (3373) embryo 14-16hr  (2550) embryo 16-18hr  (3423) embryo 18-20hr  (3112) embryo 20-22hr  (3704) embryo 22-24hr  (4078) larva L1  (5140) larva L2  (7591) larva L3 12hr old  (7190) larva L3 puffstage 1-2  (8187) larva L3 puffstage 3-6  (7977) larva L3 puffstage 7-9  (9062) white prepupae new  (7255) white prepupae 12hr  (4777) white prepupae 24hr  (4230) pupae 2d postWPP  (4319) pupae 3d postWPP  (4116) pupae 4d postWPP  (2917) adult male 01day  (4111) adult male 05day  (4364) adult male 30day  (4395) adult female 01day  (4307) adult female 05day  (6367) adult female 30day  (6491) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6182) embryo 02-04hr  (2507) embryo 04-06hr    1273 embryo 06-08hr  2094 embryo 08-10hr  (2963) embryo 10-12hr  (3742) embryo 12-14hr  (3373) embryo 14-16hr  (2550) embryo 16-18hr  (3423) embryo 18-20hr  (3112) embryo 20-22hr  (3704) embryo 22-24hr  (4078) larva L1  (5140) larva L2  (7591) larva L3 12hr old  (7190) larva L3 puffstage 1-2  (8187) larva L3 puffstage 3-6  (7977) larva L3 puffstage 7-9  (9062) white prepupae new  (7255) white prepupae 12hr  (4777) white prepupae 24hr  (4230) pupae 2d postWPP  (4319) pupae 3d postWPP  (4116) pupae 4d postWPP  (2917) adult male 01day  (4111) adult male 05day  (4364) adult male 30day  (4395) adult female 01day  (4307) adult female 05day  (6367) adult female 30day  (6491) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6182 embryo 02-04hr    2507 embryo 04-06hr    1273 embryo 06-08hr    2094 embryo 08-10hr    2963 embryo 10-12hr    3742 embryo 12-14hr    3373 embryo 14-16hr    2550 embryo 16-18hr    3423 embryo 18-20hr    3112 embryo 20-22hr    3704 embryo 22-24hr    4078 larva L1    5140 larva L2    7591 larva L3 12hr old    7190 larva L3 puffstage 1-2    8187 larva L3 puffstage 3-6    7977 larva L3 puffstage 7-9    9062 white prepupae new    7255 white prepupae 12hr    4777 white prepupae 24hr    4230 pupae 2d postWPP    4319 pupae 3d postWPP    4116 pupae 4d postWPP    2917 adult male 01day    4111 adult male 05day    4364 adult male 30day    4395 adult female 01day    4307 adult female 05day    6367 adult female 30day    6491 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6182 embryo 02-04hr    2507 embryo 04-06hr    1273 embryo 06-08hr    2094 embryo 08-10hr    2963 embryo 10-12hr    3742 embryo 12-14hr    3373 embryo 14-16hr    2550 embryo 16-18hr    3423 embryo 18-20hr    3112 embryo 20-22hr    3704 embryo 22-24hr    4078 larva L1    5140 larva L2    7591 larva L3 12hr old    7190 larva L3 puffstage 1-2    8187 larva L3 puffstage 3-6    7977 larva L3 puffstage 7-9    9062 white prepupae new    7255 white prepupae 12hr    4777 white prepupae 24hr    4230 pupae 2d postWPP    4319 pupae 3d postWPP    4116 pupae 4d postWPP    2917 adult male 01day    4111 adult male 05day    4364 adult male 30day    4395 adult female 01day    4307 adult female 05day    6367 adult female 30day    6491 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032704    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032704 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult fat body, adult female reproductive system, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032704 expression level Tissue   Expression Level Larval Central Nervous System    491.35 Larval Midgut    1679.5 Larval Hindgut    938.7 Larval Malpighian Tubules    937.4 Larval Fat Body    722.2 Larval Salivary Gland    2394.1 Larval Trachea    1135.675 Larval Carcass    778.05 Adult Head    470.2 Adult Eye    824.925 Adult Brain    398.6 Adult Thoracic-Abdominal Ganglion    440.5 Adult Crop    546.2 Adult Midgut    2139.7 Adult Hindgut    826.4 Adult Malpighian Tubules    867.6 Adult Fat Body    478.3 Adult Salivary Gland    1916.3 Adult Heart    586.3 Adult VirginFemale Spermatheca    375.9 Adult InseminatedFemale Spermatheca    420.4 Adult Ovary    346.7 Adult Testis    148 Adult Male Accessory Gland    1424.8 Adult Carcass    418.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    491.35 Larval Midgut  (1679.5) Larval Hindgut  (938.7) Larval Malpighian Tubules  (937.4) Larval Fat Body  (722.2) Larval Salivary Gland  (2394.1) Larval Trachea  (1135.675) Larval Carcass  (778.05) Adult Head    470.2 Adult Eye  (824.925) Adult Brain    398.6 Adult Thoracic-Abdominal Ganglion    440.5 Adult Crop  (546.2) Adult Midgut  (2139.7) Adult Hindgut  (826.4) Adult Malpighian Tubules  (867.6) Adult Fat Body    478.3 Adult Salivary Gland  (1916.3) Adult Heart  (586.3) Adult VirginFemale Spermatheca    375.9 Adult InseminatedFemale Spermatheca    420.4 Adult Ovary    346.7 Adult Testis    148 Adult Male Accessory Gland  (1424.8) Adult Carcass    418.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    491.35 Larval Midgut  (1679.5) Larval Hindgut    938.7 Larval Malpighian Tubules    937.4 Larval Fat Body    722.2 Larval Salivary Gland  (2394.1) Larval Trachea  (1135.675) Larval Carcass    778.05 Adult Head    470.2 Adult Eye    824.925 Adult Brain    398.6 Adult Thoracic-Abdominal Ganglion    440.5 Adult Crop    546.2 Adult Midgut  (2139.7) Adult Hindgut    826.4 Adult Malpighian Tubules    867.6 Adult Fat Body    478.3 Adult Salivary Gland  (1916.3) Adult Heart    586.3 Adult VirginFemale Spermatheca    375.9 Adult InseminatedFemale Spermatheca    420.4 Adult Ovary    346.7 Adult Testis    148 Adult Male Accessory Gland  (1424.8) Adult Carcass    418.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    491.35 Larval Midgut    1679.5 Larval Hindgut    938.7 Larval Malpighian Tubules    937.4 Larval Fat Body    722.2 Larval Salivary Gland    2394.1 Larval Trachea    1135.675 Larval Carcass    778.05 Adult Head    470.2 Adult Eye    824.925 Adult Brain    398.6 Adult Thoracic-Abdominal Ganglion    440.5 Adult Crop    546.2 Adult Midgut    2139.7 Adult Hindgut    826.4 Adult Malpighian Tubules    867.6 Adult Fat Body    478.3 Adult Salivary Gland    1916.3 Adult Heart    586.3 Adult VirginFemale Spermatheca    375.9 Adult InseminatedFemale Spermatheca    420.4 Adult Ovary    346.7 Adult Testis    148 Adult Male Accessory Gland    1424.8 Adult Carcass    418.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032704 expression level Tissue   Expression Level Larval Central Nervous System    491.35 Larval Midgut    1679.5 Larval Hindgut    938.7 Larval Malpighian Tubules    937.4 Larval Fat Body    722.2 Larval Salivary Gland    2394.1 Larval Trachea    1135.675 Larval Carcass    778.05 Adult Head    470.2 Adult Eye    824.925 Adult Brain    398.6 Adult Thoracic-Abdominal Ganglion    440.5 Adult Crop    546.2 Adult Midgut    2139.7 Adult Hindgut    826.4 Adult Malpighian Tubules    867.6 Adult Fat Body    478.3 Adult Salivary Gland    1916.3 Adult Heart    586.3 Adult VirginFemale Spermatheca    375.9 Adult InseminatedFemale Spermatheca    420.4 Adult Ovary    346.7 Adult Testis    148 Adult Male Accessory Gland    1424.8 Adult Carcass    418.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    491.35 Larval Midgut  (1679.5) Larval Hindgut  (938.7) Larval Malpighian Tubules  (937.4) Larval Fat Body  722.2 Larval Salivary Gland  (2394.1) Larval Trachea  (1135.675) Larval Carcass  778.05 Adult Head    470.2 Adult Eye  (824.925) Adult Brain    398.6 Adult Thoracic-Abdominal Ganglion    440.5 Adult Crop  546.2 Adult Midgut  (2139.7) Adult Hindgut  (826.4) Adult Malpighian Tubules  (867.6) Adult Fat Body    478.3 Adult Salivary Gland  (1916.3) Adult Heart  586.3 Adult VirginFemale Spermatheca    375.9 Adult InseminatedFemale Spermatheca    420.4 Adult Ovary    346.7 Adult Testis    148 Adult Male Accessory Gland  (1424.8) Adult Carcass    418.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    491.35 Larval Midgut  1679.5 Larval Hindgut    938.7 Larval Malpighian Tubules    937.4 Larval Fat Body    722.2 Larval Salivary Gland  (2394.1) Larval Trachea  1135.675 Larval Carcass    778.05 Adult Head    470.2 Adult Eye    824.925 Adult Brain    398.6 Adult Thoracic-Abdominal Ganglion    440.5 Adult Crop    546.2 Adult Midgut  (2139.7) Adult Hindgut    826.4 Adult Malpighian Tubules    867.6 Adult Fat Body    478.3 Adult Salivary Gland  (1916.3) Adult Heart    586.3 Adult VirginFemale Spermatheca    375.9 Adult InseminatedFemale Spermatheca    420.4 Adult Ovary    346.7 Adult Testis    148 Adult Male Accessory Gland  1424.8 Adult Carcass    418.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    491.35 Larval Midgut    1679.5 Larval Hindgut    938.7 Larval Malpighian Tubules    937.4 Larval Fat Body    722.2 Larval Salivary Gland    2394.1 Larval Trachea    1135.675 Larval Carcass    778.05 Adult Head    470.2 Adult Eye    824.925 Adult Brain    398.6 Adult Thoracic-Abdominal Ganglion    440.5 Adult Crop    546.2 Adult Midgut    2139.7 Adult Hindgut    826.4 Adult Malpighian Tubules    867.6 Adult Fat Body    478.3 Adult Salivary Gland    1916.3 Adult Heart    586.3 Adult VirginFemale Spermatheca    375.9 Adult InseminatedFemale Spermatheca    420.4 Adult Ovary    346.7 Adult Testis    148 Adult Male Accessory Gland    1424.8 Adult Carcass    418.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    470.2   NA  Eye    824.925   NA  Brain    398.6   491.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    440.5   NA  Crop    546.2   1679.5  Midgut    2139.7   938.7  Hindgut    826.4   937.4  Malpighian Tubules    867.6   722.2  Fat Body    478.3   2394.1  Salivary Gland    1916.3   NA  Heart    586.3   1135.675  Trachea    NA   NA  VirginFemale Spermatheca    375.9   NA  InseminatedFemale Spermatheca    420.4   NA  Ovary    346.7   NA  Testis    148   NA  Male Accessory Gland    1424.8   778.05  Carcass    418.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032704 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10373-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | chemical conditional, with Scer\GAL4tub.PU JwaScer\UAS.anti viable, with Scer\GAL4pnr-MD237 JwaGD1763 Other Phenotypes Allele chemical resistant, with Scer\GAL4tub.PU JwaScer\UAS.cDNA chemical sensitive, with Scer\GAL4tub.PU JwaScer\UAS.anti Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Jwa Class Mutagen Stocks Known lesion JwaG18134 P-element activity 1 -- JwaGS-A1703 Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Jwa Class Mutagen Stocks Known lesion JwaGD1763 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes JwaScer\UAS.anti in vitro construct - regulatory fusion 0 Yes JwaScer\UAS.cDNA in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6041 (Ryder, 2004.4.26) Df(2L)Exel7071 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-Jwa.anti} NA P{UAS-Jwa.cDNA} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}JwaG18134 NA P{GSV1}JwaGS-A1703 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2011-08-25)
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to ethanol inferred from mutant phenotype (Li et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
ion channel activity inferred from electronic annotation with InterPro:IPR014743 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
transmembrane transport inferred from electronic annotation with InterPro:IPR014743 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Jwa allele Gene References unspecified ct (Krupp et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61122 DroID - A comprehensive database of gene and protein interactions. • FBgn0032704 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35128
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19689 Dere\GG21690 Dgri\GH11460 Dmoj\GI16873 Dper\GL18490 Dpse\GA25658 Dsec\GM17068 Dsim\GD21814 Dvir\GJ17203 Dwil\GK18178 Dyak\GE12713
Curated drosophilid orthologs	Dpse\GA10283
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001930-PB Aedes aegypti (mosquito) AGAP005121-PB Anopheles gambiae (mosquito) XP_393613.1 Apis mellifera (honey bee) At5g02040.1 Arabidopsis thaliana (wall cress) At5g05987.1 Arabidopsis thaliana (wall cress) 102985 Branchiostoma floridae (lancelet) 243271 Branchiostoma floridae (lancelet) ENSBTAP00000028661 Bos taurus (bovine) CBP11762 Caenorhabditis briggsae (nematode) CE29245 Caenorhabditis elegans (worm) ENSCAFP00000009784 Canis familiaris (dog) JA07142 Caenorhabditis japonica (nematode) CPIJ011975 Culex pipens (mosquito) ENSCPOP00000011985 Cavia porcellus (guinea pig) ENSCSAVP00000001497 Ciona savignyi (sedentary tunicate) 118853 Capitella spl (polychaete worm) 308871 Daphnia pulex (daphnia) ENSDARP00000040803 Danio rerio (zebra fish) ENSECAP00000006704 Equus caballus (horse) ENSGACP00000004507 Gymnopilus aculeatus (mushroom) ENSGALP00000028073 Gallus gallus (chicken) 81043 Hypsipyla robusta (cedar shoot borer) ENSP00000273258 Homo sapiens (human) 188561 Lottia gigantea (owl limpet) ENSMODP00000004203 Monodelphis domestica (gray opossum) ENSMMUP00000011316 Macaca mulatta (rhesus monkey) ENSMUSP00000041503 Mus musculus (house mouse) 165971 Nematostella vectensis (starlet anemone) XP_001600741.1 Nasonia vitripennis (wasp) ENSOANP00000000777 Ornithorynchus anatinus (platypus) ENSORLP00000016929 Oryzias latipes (japanese killifish) ENSORLP00000021347 Oryzias latipes (japanese killifish) LOC_Os05g38160.1 Oryza sativa (asian rice) PHUM000101-PA Pediculus humanus (human body louse) PP14972 Pristionchus pacificus (nematode) 221990 Physcomitrella patens (moss) 227785 Physcomitrella patens (moss) ENSPPYP00000015350 Pongo pygmaeus (orangutan) 831908 Populus trichocarpa (black cottonwood) ENSPTRP00000026062 Pan troglodytes (chimpanzee) ENSRNOP00000010185 Rattus norvegicus (norway rat) 149738 Sorghum bicolor (sorghum) Smp_014800.2 Schistosoma mansoni (trematode parasite) XP_781527.2 Strongylocentrotus purpuratus (purple sea urchin) XP_968412.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005722 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000026206 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000019217 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19295 NV14791 LH20743 FBgn0230437 FBgn0220177 FBgn0204380 FBgn0193234 FBgn0171980 JGI_V11_308871 FBgn0247035 FBgn0156091 FBgn0139619 FBgn0118940 FBgn0113868 FBgn0098681 FBgn0096696 FBgn0091004 CPIJ011975 CPIJ018373 GB15184 AGAP005121 AAEL001930 PHUM491670 GLEAN_16173
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	27430 y1 w*; P{EP}JwaG18134
VDRC	v6375 w1118; P{GD1763}v6375 v6376 w1118; P{GD1763}v6376/TM3
Genomic Clones ( 2 )
	BACR07J05 BACR25C02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 51 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH05842 LP06867
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH21823 GH22958 GH27785 GM04159 LP02906 LP02918 RE27561 RE29939 RE30892 RE49222 RE51122 RE60388 SD17664 SD19670
Other clones	8973 9357 35219 43086 63401 74976 527045 542792 557141 569111 CK01.100A.E2 CK01.132A.C10 EC36338 EC39491 EK084637 EK095041 EK145524 EK190227 EK207713 EN07159 EN11335 EN12129 EN14548 ESG0111a.B21_B01 GM14181 RM06639 RM06739 RM06839 RM07039 RM07139 RM07239 RM07339 RP001006523 RP001019621 RP001021495
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032704 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35128
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Jwa CG10373 (Li et al., 2008)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136057 RefSeq (Proteins) • NP_609901 DDBJ / EMBL / GenBank • AAF53696 AAM11031 AI107942 AW940211 AY094678 Entrez Gene - A searchable database of RefSeq genes. • 35128 UniProtKB/TrEMBL • Q8SXD0 Q9VJ59
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Prenylated rab acceptor PRA1 (IPR004895) Chloride channel, core (IPR014743)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61122 DroID - A comprehensive database of gene and protein interactions. • FBgn0032704 DRSC - Results from RNAi screens. • FBgn0032704 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032704 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10373-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032704 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35128 InParanoid A subset of ortholog calls from InParanoid. • AAEL001930-PB Aedes aegypti (mosquito) AGAP005121-PB Anopheles gambiae (mosquito) XP_393613.1 Apis mellifera (honey bee) At5g02040.1 Arabidopsis thaliana (wall cress) At5g05987.1 Arabidopsis thaliana (wall cress) 102985 Branchiostoma floridae (lancelet) 243271 Branchiostoma floridae (lancelet) ENSBTAP00000028661 Bos taurus (bovine) CBP11762 Caenorhabditis briggsae (nematode) CE29245 Caenorhabditis elegans (worm) ENSCAFP00000009784 Canis familiaris (dog) JA07142 Caenorhabditis japonica (nematode) CPIJ011975 Culex pipens (mosquito) ENSCPOP00000011985 Cavia porcellus (guinea pig) ENSCSAVP00000001497 Ciona savignyi (sedentary tunicate) 118853 Capitella spl (polychaete worm) 308871 Daphnia pulex (daphnia) ENSDARP00000040803 Danio rerio (zebra fish) ENSECAP00000006704 Equus caballus (horse) ENSGACP00000004507 Gymnopilus aculeatus (mushroom) ENSGALP00000028073 Gallus gallus (chicken) 81043 Hypsipyla robusta (cedar shoot borer) ENSP00000273258 Homo sapiens (human) 188561 Lottia gigantea (owl limpet) ENSMODP00000004203 Monodelphis domestica (gray opossum) ENSMMUP00000011316 Macaca mulatta (rhesus monkey) ENSMUSP00000041503 Mus musculus (house mouse) 165971 Nematostella vectensis (starlet anemone) XP_001600741.1 Nasonia vitripennis (wasp) ENSOANP00000000777 Ornithorynchus anatinus (platypus) ENSORLP00000016929 Oryzias latipes (japanese killifish) ENSORLP00000021347 Oryzias latipes (japanese killifish) LOC_Os05g38160.1 Oryza sativa (asian rice) PHUM000101-PA Pediculus humanus (human body louse) PP14972 Pristionchus pacificus (nematode) 221990 Physcomitrella patens (moss) 227785 Physcomitrella patens (moss) ENSPPYP00000015350 Pongo pygmaeus (orangutan) 831908 Populus trichocarpa (black cottonwood) ENSPTRP00000026062 Pan troglodytes (chimpanzee) ENSRNOP00000010185 Rattus norvegicus (norway rat) 149738 Sorghum bicolor (sorghum) Smp_014800.2 Schistosoma mansoni (trematode parasite) XP_781527.2 Strongylocentrotus purpuratus (purple sea urchin) XP_968412.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005722 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000026206 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000019217 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35128 modMine - Data generated by the modENCODE project. • FBgn0032704 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19295 NV14791 LH20743 FBgn0230437 FBgn0220177 FBgn0204380 FBgn0193234 FBgn0171980 JGI_V11_308871 FBgn0247035 FBgn0156091 FBgn0139619 FBgn0118940 FBgn0113868 FBgn0098681 FBgn0096696 FBgn0091004 CPIJ011975 CPIJ018373 GB15184 AGAP005121 AAEL001930 PHUM491670 GLEAN_16173
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG10373 (Li et al., 2008, Stuart et al., 2007, Cammarato et al., 2011) djwa (Li et al., 2008) Jwa
Name Synonym	Jwa ortholog
Secondary FlyBase IDs
References ( 14 )
Research paper	Li et al., 2008, Alcohol Alcohol. 43(5): 529--536 The Drosophila homolog of jwa is required for ethanol tolerance. [FBrf0213977] Stuart et al., 2007, Nature 445(7123): 95--101 A systems biology analysis of the Drosophila phagosome. [FBrf0195342] Krupp et al., 2005, Genetics 170(4): 1775--1795 Identification of genetic loci that interact with cut during Drosophila wing-margin development. [FBrf0187644]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2009.5.5, BDGP_2009_0507.GenExel.xml BDGP_2009_0507.GenExel.xml [FBrf0207859] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]