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Gene Dmel\Nedd8

General Information
Symbol	Dmel\Nedd8	Species	D. melanogaster
Name	Nedd8	Annotation symbol	CG10679
Feature type	protein_coding_gene	FlyBase ID	FBgn0032725
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	37B7-37B7	Sequence location	2L:18,951,147..18,951,845 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Nedd8 is referred to in FlyBase by the symbol Dmel\Nedd8 (CG10679, FBgn0032725). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: regulation of ubiquitin-protein ligase activity; regulation of protein stability; regulation of smoothened signaling pathway; cell proliferation; protein neddylation; regulation of proteolysis; neurogenesis. 17 alleles are reported. The phenotype of these alleles is annotated with: mushroom body. It has one annotated transcript and one annotated polypeptide. Protein features are: Ubiquitin; Ubiquitin conserved site; Ubiquitin subgroup; Ubiquitin supergroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624883_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Nedd8. Gene sequence location is 2L:18951147..18951845.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Du et al., 2011, PLoS ONE 6(9): e24168 Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features BKN42114 HFA02092
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37B7-37B7   Limits computationally determined from genome sequence between P{EP}CG10413EP2164 and P{lacW}l(2)37Dbk16106&P{lacW}Catsupk05424
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nedd8 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nedd8-RA FBtr0081192  NM_136075   479   84
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nedd8-PA   FBpp0080733   9.3   84   5.88     NP_609919   AAF53724
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin (IPR000626) Ubiquitin conserved site (IPR019954) Ubiquitin supergroup (IPR019955) Ubiquitin subgroup (IPR019956)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53724   AI534749   BP546010   BP547218   BP548567   BP550739   BP551004   BP552193   BP552194   BT024445   CO179815   CO271464   CO315549   EC066388   EC071612   EC197624   EC208996   EC209006   EL869628   EV576470   EV587348   GH941709   GH941958   GH943193   GH947183   GH947248   GH947380   GH955808   GH956884   GH966057   GH966115   GH967368   GH969188   GH974423   GH978135   GH979156   GH979744   GH980680   GH983291
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VJ33
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032725    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032725 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032725 expression level Developmental Stage   Expression Level embryo 00-02hr    5802 embryo 02-04hr    9890 embryo 04-06hr    9430 embryo 06-08hr    4254 embryo 08-10hr    3929 embryo 10-12hr    2093 embryo 12-14hr    2546 embryo 14-16hr    1009 embryo 16-18hr    1045 embryo 18-20hr    762 embryo 20-22hr    1040 embryo 22-24hr    1441 larva L1    1618 larva L2    3513 larva L3 12hr old    2575 larva L3 puffstage 1-2    3094 larva L3 puffstage 3-6    3755 larva L3 puffstage 7-9    5491 white prepupae new    5918 white prepupae 12hr    5328 white prepupae 24hr    4902 pupae 2d postWPP    3945 pupae 3d postWPP    2996 pupae 4d postWPP    1793 adult male 01day    2456 adult male 05day    2213 adult male 30day    1790 adult female 01day    2122 adult female 05day    5528 adult female 30day    4265 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5802) embryo 02-04hr  (9890) embryo 04-06hr  (9430) embryo 06-08hr  (4254) embryo 08-10hr  (3929) embryo 10-12hr  (2093) embryo 12-14hr  (2546) embryo 14-16hr  (1009) embryo 16-18hr  (1045) embryo 18-20hr  (762) embryo 20-22hr  (1040) embryo 22-24hr  (1441) larva L1  (1618) larva L2  (3513) larva L3 12hr old  (2575) larva L3 puffstage 1-2  (3094) larva L3 puffstage 3-6  (3755) larva L3 puffstage 7-9  (5491) white prepupae new  (5918) white prepupae 12hr  (5328) white prepupae 24hr  (4902) pupae 2d postWPP  (3945) pupae 3d postWPP  (2996) pupae 4d postWPP  (1793) adult male 01day  (2456) adult male 05day  (2213) adult male 30day  (1790) adult female 01day  (2122) adult female 05day  (5528) adult female 30day  (4265) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5802) embryo 02-04hr  (9890) embryo 04-06hr  (9430) embryo 06-08hr  (4254) embryo 08-10hr  (3929) embryo 10-12hr  (2093) embryo 12-14hr  (2546) embryo 14-16hr    1009 embryo 16-18hr    1045 embryo 18-20hr    762 embryo 20-22hr    1040 embryo 22-24hr  1441 larva L1  (1618) larva L2  (3513) larva L3 12hr old  (2575) larva L3 puffstage 1-2  (3094) larva L3 puffstage 3-6  (3755) larva L3 puffstage 7-9  (5491) white prepupae new  (5918) white prepupae 12hr  (5328) white prepupae 24hr  (4902) pupae 2d postWPP  (3945) pupae 3d postWPP  (2996) pupae 4d postWPP  (1793) adult male 01day  (2456) adult male 05day  (2213) adult male 30day  (1790) adult female 01day  (2122) adult female 05day  (5528) adult female 30day  (4265) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5802 embryo 02-04hr    9890 embryo 04-06hr    9430 embryo 06-08hr    4254 embryo 08-10hr    3929 embryo 10-12hr    2093 embryo 12-14hr    2546 embryo 14-16hr    1009 embryo 16-18hr    1045 embryo 18-20hr    762 embryo 20-22hr    1040 embryo 22-24hr    1441 larva L1    1618 larva L2    3513 larva L3 12hr old    2575 larva L3 puffstage 1-2    3094 larva L3 puffstage 3-6    3755 larva L3 puffstage 7-9    5491 white prepupae new    5918 white prepupae 12hr    5328 white prepupae 24hr    4902 pupae 2d postWPP    3945 pupae 3d postWPP    2996 pupae 4d postWPP    1793 adult male 01day    2456 adult male 05day    2213 adult male 30day    1790 adult female 01day    2122 adult female 05day    5528 adult female 30day    4265 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5802 embryo 02-04hr    9890 embryo 04-06hr    9430 embryo 06-08hr    4254 embryo 08-10hr    3929 embryo 10-12hr    2093 embryo 12-14hr    2546 embryo 14-16hr    1009 embryo 16-18hr    1045 embryo 18-20hr    762 embryo 20-22hr    1040 embryo 22-24hr    1441 larva L1    1618 larva L2    3513 larva L3 12hr old    2575 larva L3 puffstage 1-2    3094 larva L3 puffstage 3-6    3755 larva L3 puffstage 7-9    5491 white prepupae new    5918 white prepupae 12hr    5328 white prepupae 24hr    4902 pupae 2d postWPP    3945 pupae 3d postWPP    2996 pupae 4d postWPP    1793 adult male 01day    2456 adult male 05day    2213 adult male 30day    1790 adult female 01day    2122 adult female 05day    5528 adult female 30day    4265 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032725 expression level Developmental Stage   Expression Level embryo 00-02hr    5802 embryo 02-04hr    9890 embryo 04-06hr    9430 embryo 06-08hr    4254 embryo 08-10hr    3929 embryo 10-12hr    2093 embryo 12-14hr    2546 embryo 14-16hr    1009 embryo 16-18hr    1045 embryo 18-20hr    762 embryo 20-22hr    1040 embryo 22-24hr    1441 larva L1    1618 larva L2    3513 larva L3 12hr old    2575 larva L3 puffstage 1-2    3094 larva L3 puffstage 3-6    3755 larva L3 puffstage 7-9    5491 white prepupae new    5918 white prepupae 12hr    5328 white prepupae 24hr    4902 pupae 2d postWPP    3945 pupae 3d postWPP    2996 pupae 4d postWPP    1793 adult male 01day    2456 adult male 05day    2213 adult male 30day    1790 adult female 01day    2122 adult female 05day    5528 adult female 30day    4265 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5802) embryo 02-04hr  (9890) embryo 04-06hr  (9430) embryo 06-08hr  (4254) embryo 08-10hr  (3929) embryo 10-12hr  (2093) embryo 12-14hr  (2546) embryo 14-16hr  (1009) embryo 16-18hr  (1045) embryo 18-20hr  (762) embryo 20-22hr  (1040) embryo 22-24hr  (1441) larva L1  (1618) larva L2  (3513) larva L3 12hr old  (2575) larva L3 puffstage 1-2  (3094) larva L3 puffstage 3-6  (3755) larva L3 puffstage 7-9  (5491) white prepupae new  (5918) white prepupae 12hr  (5328) white prepupae 24hr  (4902) pupae 2d postWPP  (3945) pupae 3d postWPP  (2996) pupae 4d postWPP  (1793) adult male 01day  (2456) adult male 05day  (2213) adult male 30day  (1790) adult female 01day  (2122) adult female 05day  (5528) adult female 30day  (4265) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5802) embryo 02-04hr  (9890) embryo 04-06hr  (9430) embryo 06-08hr  (4254) embryo 08-10hr  (3929) embryo 10-12hr  2093 embryo 12-14hr  (2546) embryo 14-16hr    1009 embryo 16-18hr    1045 embryo 18-20hr    762 embryo 20-22hr    1040 embryo 22-24hr  1441 larva L1  1618 larva L2  (3513) larva L3 12hr old  (2575) larva L3 puffstage 1-2  (3094) larva L3 puffstage 3-6  (3755) larva L3 puffstage 7-9  (5491) white prepupae new  (5918) white prepupae 12hr  (5328) white prepupae 24hr  (4902) pupae 2d postWPP  (3945) pupae 3d postWPP  (2996) pupae 4d postWPP  1793 adult male 01day  2456 adult male 05day  2213 adult male 30day  1790 adult female 01day  2122 adult female 05day  (5528) adult female 30day  (4265) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5802 embryo 02-04hr    9890 embryo 04-06hr    9430 embryo 06-08hr    4254 embryo 08-10hr    3929 embryo 10-12hr    2093 embryo 12-14hr    2546 embryo 14-16hr    1009 embryo 16-18hr    1045 embryo 18-20hr    762 embryo 20-22hr    1040 embryo 22-24hr    1441 larva L1    1618 larva L2    3513 larva L3 12hr old    2575 larva L3 puffstage 1-2    3094 larva L3 puffstage 3-6    3755 larva L3 puffstage 7-9    5491 white prepupae new    5918 white prepupae 12hr    5328 white prepupae 24hr    4902 pupae 2d postWPP    3945 pupae 3d postWPP    2996 pupae 4d postWPP    1793 adult male 01day    2456 adult male 05day    2213 adult male 30day    1790 adult female 01day    2122 adult female 05day    5528 adult female 30day    4265 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5802 embryo 02-04hr    9890 embryo 04-06hr    9430 embryo 06-08hr    4254 embryo 08-10hr    3929 embryo 10-12hr    2093 embryo 12-14hr    2546 embryo 14-16hr    1009 embryo 16-18hr    1045 embryo 18-20hr    762 embryo 20-22hr    1040 embryo 22-24hr    1441 larva L1    1618 larva L2    3513 larva L3 12hr old    2575 larva L3 puffstage 1-2    3094 larva L3 puffstage 3-6    3755 larva L3 puffstage 7-9    5491 white prepupae new    5918 white prepupae 12hr    5328 white prepupae 24hr    4902 pupae 2d postWPP    3945 pupae 3d postWPP    2996 pupae 4d postWPP    1793 adult male 01day    2456 adult male 05day    2213 adult male 30day    1790 adult female 01day    2122 adult female 05day    5528 adult female 30day    4265 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032725    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032725 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032725 expression level Tissue   Expression Level Larval Central Nervous System    762.55 Larval Midgut    283.4 Larval Hindgut    555.8 Larval Malpighian Tubules    578.1 Larval Fat Body    549.3 Larval Salivary Gland    574.6 Larval Trachea    611.975 Larval Carcass    641.875 Adult Head    329 Adult Eye    443.325 Adult Brain    240.2 Adult Thoracic-Abdominal Ganglion    305.4 Adult Crop    496.5 Adult Midgut    276.7 Adult Hindgut    385.3 Adult Malpighian Tubules    280.5 Adult Fat Body    472.2 Adult Salivary Gland    406.5 Adult Heart    521.8 Adult VirginFemale Spermatheca    343.9 Adult InseminatedFemale Spermatheca    409.5 Adult Ovary    641.6 Adult Testis    338.3 Adult Male Accessory Gland    380.8 Adult Carcass    347.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (762.55) Larval Midgut    283.4 Larval Hindgut  (555.8) Larval Malpighian Tubules  (578.1) Larval Fat Body  (549.3) Larval Salivary Gland  (574.6) Larval Trachea  (611.975) Larval Carcass  (641.875) Adult Head    329 Adult Eye    443.325 Adult Brain    240.2 Adult Thoracic-Abdominal Ganglion    305.4 Adult Crop    496.5 Adult Midgut    276.7 Adult Hindgut    385.3 Adult Malpighian Tubules    280.5 Adult Fat Body    472.2 Adult Salivary Gland    406.5 Adult Heart  521.8 Adult VirginFemale Spermatheca    343.9 Adult InseminatedFemale Spermatheca    409.5 Adult Ovary  (641.6) Adult Testis    338.3 Adult Male Accessory Gland    380.8 Adult Carcass    347.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    762.55 Larval Midgut    283.4 Larval Hindgut    555.8 Larval Malpighian Tubules    578.1 Larval Fat Body    549.3 Larval Salivary Gland    574.6 Larval Trachea    611.975 Larval Carcass    641.875 Adult Head    329 Adult Eye    443.325 Adult Brain    240.2 Adult Thoracic-Abdominal Ganglion    305.4 Adult Crop    496.5 Adult Midgut    276.7 Adult Hindgut    385.3 Adult Malpighian Tubules    280.5 Adult Fat Body    472.2 Adult Salivary Gland    406.5 Adult Heart    521.8 Adult VirginFemale Spermatheca    343.9 Adult InseminatedFemale Spermatheca    409.5 Adult Ovary    641.6 Adult Testis    338.3 Adult Male Accessory Gland    380.8 Adult Carcass    347.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    762.55 Larval Midgut    283.4 Larval Hindgut    555.8 Larval Malpighian Tubules    578.1 Larval Fat Body    549.3 Larval Salivary Gland    574.6 Larval Trachea    611.975 Larval Carcass    641.875 Adult Head    329 Adult Eye    443.325 Adult Brain    240.2 Adult Thoracic-Abdominal Ganglion    305.4 Adult Crop    496.5 Adult Midgut    276.7 Adult Hindgut    385.3 Adult Malpighian Tubules    280.5 Adult Fat Body    472.2 Adult Salivary Gland    406.5 Adult Heart    521.8 Adult VirginFemale Spermatheca    343.9 Adult InseminatedFemale Spermatheca    409.5 Adult Ovary    641.6 Adult Testis    338.3 Adult Male Accessory Gland    380.8 Adult Carcass    347.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032725 expression level Tissue   Expression Level Larval Central Nervous System    762.55 Larval Midgut    283.4 Larval Hindgut    555.8 Larval Malpighian Tubules    578.1 Larval Fat Body    549.3 Larval Salivary Gland    574.6 Larval Trachea    611.975 Larval Carcass    641.875 Adult Head    329 Adult Eye    443.325 Adult Brain    240.2 Adult Thoracic-Abdominal Ganglion    305.4 Adult Crop    496.5 Adult Midgut    276.7 Adult Hindgut    385.3 Adult Malpighian Tubules    280.5 Adult Fat Body    472.2 Adult Salivary Gland    406.5 Adult Heart    521.8 Adult VirginFemale Spermatheca    343.9 Adult InseminatedFemale Spermatheca    409.5 Adult Ovary    641.6 Adult Testis    338.3 Adult Male Accessory Gland    380.8 Adult Carcass    347.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  762.55 Larval Midgut    283.4 Larval Hindgut  555.8 Larval Malpighian Tubules  578.1 Larval Fat Body  549.3 Larval Salivary Gland  574.6 Larval Trachea  611.975 Larval Carcass  641.875 Adult Head    329 Adult Eye    443.325 Adult Brain    240.2 Adult Thoracic-Abdominal Ganglion    305.4 Adult Crop    496.5 Adult Midgut    276.7 Adult Hindgut    385.3 Adult Malpighian Tubules    280.5 Adult Fat Body    472.2 Adult Salivary Gland    406.5 Adult Heart  521.8 Adult VirginFemale Spermatheca    343.9 Adult InseminatedFemale Spermatheca    409.5 Adult Ovary  641.6 Adult Testis    338.3 Adult Male Accessory Gland    380.8 Adult Carcass    347.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    762.55 Larval Midgut    283.4 Larval Hindgut    555.8 Larval Malpighian Tubules    578.1 Larval Fat Body    549.3 Larval Salivary Gland    574.6 Larval Trachea    611.975 Larval Carcass    641.875 Adult Head    329 Adult Eye    443.325 Adult Brain    240.2 Adult Thoracic-Abdominal Ganglion    305.4 Adult Crop    496.5 Adult Midgut    276.7 Adult Hindgut    385.3 Adult Malpighian Tubules    280.5 Adult Fat Body    472.2 Adult Salivary Gland    406.5 Adult Heart    521.8 Adult VirginFemale Spermatheca    343.9 Adult InseminatedFemale Spermatheca    409.5 Adult Ovary    641.6 Adult Testis    338.3 Adult Male Accessory Gland    380.8 Adult Carcass    347.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    762.55 Larval Midgut    283.4 Larval Hindgut    555.8 Larval Malpighian Tubules    578.1 Larval Fat Body    549.3 Larval Salivary Gland    574.6 Larval Trachea    611.975 Larval Carcass    641.875 Adult Head    329 Adult Eye    443.325 Adult Brain    240.2 Adult Thoracic-Abdominal Ganglion    305.4 Adult Crop    496.5 Adult Midgut    276.7 Adult Hindgut    385.3 Adult Malpighian Tubules    280.5 Adult Fat Body    472.2 Adult Salivary Gland    406.5 Adult Heart    521.8 Adult VirginFemale Spermatheca    343.9 Adult InseminatedFemale Spermatheca    409.5 Adult Ovary    641.6 Adult Testis    338.3 Adult Male Accessory Gland    380.8 Adult Carcass    347.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    329   NA  Eye    443.325   NA  Brain    240.2   762.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    305.4   NA  Crop    496.5   283.4  Midgut    276.7   555.8  Hindgut    385.3   578.1  Malpighian Tubules    280.5   549.3  Fat Body    472.2   574.6  Salivary Gland    406.5   NA  Heart    521.8   611.975  Trachea    NA   NA  VirginFemale Spermatheca    343.9   NA  InseminatedFemale Spermatheca    409.5   NA  Ovary    641.6   NA  Testis    338.3   NA  Male Accessory Gland    380.8   641.875  Carcass    347.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032725 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10679-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 Nedd8GD12964 lethal (with Df(2L)TW3) Nedd8AN015 Nedd8AN024 lethal | larval stage | recessive Nedd8AN024 lethal | pupal stage, with Scer\GAL4pnr-MD237 Nedd8GD12964 lethal | pupal stage (with Nedd8AN015) Nedd8EP2063 lethal | pupal stage (with Nedd8AN024) Nedd8EP2063 lethal | pupal stage (with Nedd8EP2063) Nedd8AN015 Nedd8AN024 Sterility Allele female sterile | germline clone Nedd8unspecified Other Phenotypes Allele neuroanatomy defective Nedd8AN015 neuroanatomy defective | larval stage, with Scer\GAL41407 Nedd8GD12964 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 Nedd8GD12964 eye disc | somatic clone Nedd8AN015 ganglion mother cell | larval stage, with Scer\GAL41407 Nedd8GD12964 mushroom body Nedd8AN015 neuron & gamma-lobe Nedd8AN015 ovary | germline clone Nedd8unspecified
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Nedd8 Class Mutagen Stocks Known lesion Nedd8KG03071 2 -- Nedd8EP2063 hypomorphic allele - genetic evidence P-element activity 1 Yes Nedd8G7338 P-element activity 1 -- Nedd8172 loss of function allele P-element activity 0 Yes Nedd8203 hypomorphic allele - genetic evidence P-element activity 0 Yes Nedd8AN015 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Nedd8AN024 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Nedd8unspecified 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nedd8 Class Mutagen Stocks Known lesion Nedd8GD12964 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Nedd8HMS00818 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nedd8AA.Scer\UAS.T:Hsap\MYC,T:Avic\GFP-CFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Nedd8AA.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes Nedd8GG.Scer\UAS.T:Hsap\MYC,T:Avic\GFP-CFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Nedd8GG.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Nedd8m.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Nedd8Scer\UAS.T:Avic\GFP-YFP 0 Yes Nedd8VP.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7073 (Ryder, 2004.4.26) Df(2L)TW3 (Ou et al., 2002)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12964} NA P{TRiP.HMS00818} NA P{UAS-myc-mNedd8} NA P{UAS-myc-Nedd8.AA} NA P{UAS-myc-Nedd8.GG} NA P{UAS-myc-Nedd8.VP} NA P{UAS-myc-Nedd8-AA-CFP} NA P{UAS-myc-Nedd8-GG-CFP} NA P{UAS-YFP-Nedd8} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Nedd8EP2063 NA P{EP}Nedd8G7338 NA miscellaneous insertions P{SUPor-P}Nedd8KG03071 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell proliferation inferred from mutant phenotype (assigned by UniProtKB) (Ou et al., 2002) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) protein neddylation inferred from mutant phenotype (Rencus-Lazar et al., 2008) regulation of protein stability inferred from mutant phenotype (assigned by UniProtKB) (Ou et al., 2002) regulation of proteolysis inferred from mutant phenotype (assigned by UniProtKB) (Ou et al., 2002) regulation of smoothened signaling pathway inferred from mutant phenotype (assigned by UniProtKB) (Ou et al., 2002) regulation of ubiquitin-protein ligase activity inferred from mutant phenotype (assigned by UniProtKB) (Ou et al., 2002)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nedd8 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61142 DroID - A comprehensive database of gene and protein interactions. • FBgn0032725 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35151
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14648 Dere\GG21672 Dgri\GH11603 Dmoj\GI17172 Dper\GL19627 Dpse\GA10488 Dsec\GM17051 Dsim\GD21798 Dvir\GJ17678 Dwil\GK24685 Dyak\GE12693
Curated drosophilid orthologs	Dpse\GA10488
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000679-PA Aedes aegypti (mosquito) AGAP007913-PA Anopheles gambiae (mosquito) XP_625200.1 Apis mellifera (honey bee) XP_001945024.1 Acyrthosiphon pisum (pea aphid) 87050 Batrachochytrium dendrobatidis (chytrid fungus) 268773 Branchiostoma floridae (lancelet) 284180 Branchiostoma floridae (lancelet) BGIBMGA007334-PA Bombyx mori (silk worm) ENSBTAP00000050599 Bos taurus (bovine) CAF0006894 Candida albicans (a form of yeast) CN00281 Caenorhabditis brenneri (small nematode) CBP03105 Caenorhabditis briggsae (nematode) CE10552 Caenorhabditis elegans (worm) ENSCAFP00000017809 Canis familiaris (dog) JA11017 Caenorhabditis japonica (nematode) CML042C Cyanidioschyzon merolae (red alga) CPIJ001487 Culex pipens (mosquito) ENSCPOP00000009821 Cavia porcellus (guinea pig) RP11418 Caenorhabditis remanei (nematode) 174075 Capitella spl (polychaete worm) DDB0238041 Dictyostelium discoideum (amoeba) DEHA2D07194g Debaryomyces Hansenii (yeast) ENSDARP00000021095 Danio rerio (zebra fish) ENSECAP00000016779 Equus caballus (horse) ENSGACP00000018754 Gymnopilus aculeatus (mushroom) ENSGALP00000004703 Gallus gallus (chicken) ENSP00000250495 Homo sapiens (human) ISCW023133-PA Ixodes scapularis (deer tick) 177660 Lottia gigantea (owl limpet) ENSMODP00000003964 Monodelphis domestica (gray opossum) ENSMMUP00000033047 Macaca mulatta (rhesus monkey) ENSMUSP00000010520 Mus musculus (house mouse) XP_001599314.1 Nasonia vitripennis (wasp) 7796 Ostreococcus tauri (green alga) PHUM003376-PA Pediculus humanus (human body louse) ENSPPYP00000006472 Pongo pygmaeus (orangutan) 562862 Populus trichocarpa (black cottonwood) ENSPTRP00000010537 Pan troglodytes (chimpanzee) ENSRNOP00000026950 Rattus norvegicus (norway rat) Smp_130170 Schistosoma mansoni (trematode parasite) SPBC12D12.08c Schizosaccharomyces pombe (fission yeast) XP_001185694.1 Strongylocentrotus purpuratus (purple sea urchin) 50199 Trichoplax adhaerens (metazoa) XP_001814830.1 Tribolium castaneum (red flour beetle) Tc00.1047053447255.4 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506559.59 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000003565 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000010766 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000016850 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011742 Takifugu rubripes (pufferfish Takifugu) 3713.m00145 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000015552 Xenopus tropicalis (frog) YALI0F18403g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17337 ISCW023133 FBgn0230418 FBgn0226645 FBgn0204847 FBgn0193218 FBgn0171963 FBgn0070545 FBgn0157225 FBgn0139916 FBgn0119083 FBgn0113850 FBgn0091675 CPIJ001487 BGIBMGA007334 ACYPI008479 GB17785 AGAP007913 AAEL000679 PHUM442590 GLEAN_14299
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	27961 y1 w*; P{EP}Nedd8G7338/CyO 13769 y1; P{SUPor-P}Nedd8KG03071; ry506 33881 y1 sc* v1; P{TRiP.HMS00818}attP2/TM3, Sb1
Kyoto	122047 w1118; P{EP}Nedd8EP2063 114377 yd2 w1118 P{ey-FLP.N}2; P{SUPor-P}Nedd8KG03071 P{neoFRT}40A/CyO y+
VDRC	v28444 w1118; P{GD12964}v28444 v28445 w1118; P{GD12964}v28445
Genomic Clones ( 2 )
	BACR03E19 BACR17A06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 35 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP01714
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	158644 CK01.169A.F7 CK01.169C.F7 Dmel_dig_007156_0709_0313 Dmel_neb_012060_0198_0462 EC00265 EK103524 EK261819 FGH101H05 FGH114F08 FGH129B06 FGM208H01 FGM210D08 FGM217D03 IP01715 RP004069963 RP004091048 RP004209670 RP004211224 RP004211559 RP004212663 RP004238698 RP004247914 RP004253205 RP004254825 RP004261205 RP004262961 RP004263230 RP004363882 RP004444807 RP004468563 RP004483125 RP004484042 SD07755
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032725 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35151
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Nedd8 CG10679 (Lin, 2002.3.18)
Source for database merge of
Additional comments
Other Comments
	Nedd8 interacts with members of the Cullin family and is essential for SCF activities in Drosophila. (Lin et al., 2002) Mutant larvae and adults show pleiotrophic terminal phenotypes. (Lin et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136075 RefSeq (Proteins) • NP_609919 DDBJ / EMBL / GenBank • AAF53724 Entrez Gene - A searchable database of RefSeq genes. • 35151 UniProtKB/TrEMBL • Q9VJ33
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin (IPR000626) Ubiquitin conserved site (IPR019954) Ubiquitin supergroup (IPR019955) Ubiquitin subgroup (IPR019956)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61142 DroID - A comprehensive database of gene and protein interactions. • FBgn0032725 DRSC - Results from RNAi screens. • FBgn0032725 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032725 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10679-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032725 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35151 InParanoid A subset of ortholog calls from InParanoid. • AAEL000679-PA Aedes aegypti (mosquito) AGAP007913-PA Anopheles gambiae (mosquito) XP_625200.1 Apis mellifera (honey bee) XP_001945024.1 Acyrthosiphon pisum (pea aphid) 87050 Batrachochytrium dendrobatidis (chytrid fungus) 268773 Branchiostoma floridae (lancelet) 284180 Branchiostoma floridae (lancelet) BGIBMGA007334-PA Bombyx mori (silk worm) ENSBTAP00000050599 Bos taurus (bovine) CAF0006894 Candida albicans (a form of yeast) CN00281 Caenorhabditis brenneri (small nematode) CBP03105 Caenorhabditis briggsae (nematode) CE10552 Caenorhabditis elegans (worm) ENSCAFP00000017809 Canis familiaris (dog) JA11017 Caenorhabditis japonica (nematode) CML042C Cyanidioschyzon merolae (red alga) CPIJ001487 Culex pipens (mosquito) ENSCPOP00000009821 Cavia porcellus (guinea pig) RP11418 Caenorhabditis remanei (nematode) 174075 Capitella spl (polychaete worm) DDB0238041 Dictyostelium discoideum (amoeba) DEHA2D07194g Debaryomyces Hansenii (yeast) ENSDARP00000021095 Danio rerio (zebra fish) ENSECAP00000016779 Equus caballus (horse) ENSGACP00000018754 Gymnopilus aculeatus (mushroom) ENSGALP00000004703 Gallus gallus (chicken) ENSP00000250495 Homo sapiens (human) ISCW023133-PA Ixodes scapularis (deer tick) 177660 Lottia gigantea (owl limpet) ENSMODP00000003964 Monodelphis domestica (gray opossum) ENSMMUP00000033047 Macaca mulatta (rhesus monkey) ENSMUSP00000010520 Mus musculus (house mouse) XP_001599314.1 Nasonia vitripennis (wasp) 7796 Ostreococcus tauri (green alga) PHUM003376-PA Pediculus humanus (human body louse) ENSPPYP00000006472 Pongo pygmaeus (orangutan) 562862 Populus trichocarpa (black cottonwood) ENSPTRP00000010537 Pan troglodytes (chimpanzee) ENSRNOP00000026950 Rattus norvegicus (norway rat) Smp_130170 Schistosoma mansoni (trematode parasite) SPBC12D12.08c Schizosaccharomyces pombe (fission yeast) XP_001185694.1 Strongylocentrotus purpuratus (purple sea urchin) 50199 Trichoplax adhaerens (metazoa) XP_001814830.1 Tribolium castaneum (red flour beetle) Tc00.1047053447255.4 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506559.59 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000003565 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000010766 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000016850 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011742 Takifugu rubripes (pufferfish Takifugu) 3713.m00145 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000015552 Xenopus tropicalis (frog) YALI0F18403g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35151 modMine - Data generated by the modENCODE project. • FBgn0032725 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17337 ISCW023133 FBgn0230418 FBgn0226645 FBgn0204847 FBgn0193218 FBgn0171963 FBgn0070545 FBgn0157225 FBgn0139916 FBgn0119083 FBgn0113850 FBgn0091675 CPIJ001487 BGIBMGA007334 ACYPI008479 GB17785 AGAP007913 AAEL000679 PHUM442590 GLEAN_14299
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG10679 (Ni et al., 2010.12.1) dNEDD8 (Du et al., 2011) nedd8 (Wu and Chien, 2004, Oren-Giladi et al., 2008) Nedd8 (Zhu et al., 2005, Liebl et al., 2006, Cope et al., 2002, Wu et al., 2005, Reynolds et al., 2008, Ou et al., 2007, Chan et al., 2008, Chan et al., 2008, Djagaeva and Doronkin, 2009, Rencus-Lazar et al., 2008, Engström et al., 2007, Goto et al., 2011, Kim et al., 2010, Neumüller et al., 2011)
Name Synonym	Nedd8   neural precursor cell-expressed developmentally downregulated (Zhu et al., 2005)
Secondary FlyBase IDs
References ( 38 )
Generate a list of	All references relating to this gene ( 38 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 4 )
	Du et al., 2011, PLoS ONE 6(9): e24168 In Vivo RNAi Screen Reveals Neddylation Genes as Novel Regulators of Hedgehog Signaling. [FBrf0215574] Goto et al., 2011, J. Neurosci. 31(14): 5454--5459 Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. [FBrf0213400] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Kim et al., 2010, Dev. Biol. 346(2): 247--257 Drosophila Cand1 regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein. [FBrf0211875] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...