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Gene Dmel\CG10188

General Information
Symbol	Dmel\CG10188	Species	D. melanogaster
Name		Annotation symbol	CG10188
Feature type	protein_coding_gene	FlyBase ID	FBgn0032796
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	37E4-37E5	Sequence location	2L:19,502,334..19,508,760 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG10188 (FBgn0032796). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: Rho guanyl-nucleotide exchange factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: regulation of Rho protein signal transduction. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Dbl homology (DH) domain; Pleckstrin homology domain; Pleckstrin homology-type; Rho GTP exchange factor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult brain. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval Malpighian tubules, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1633757_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG10188. Gene sequence location is 2L:19502334..19508760.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Bakal et al., 2007, Science 316(5832): 1753--1756
FB2012_01	Sequence features BKN20500 HFA02023 BKN45681
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37E4-37E5   Limits computationally determined from genome sequence between P{EP}dntEP2158 and P{EP}EP623&P{PZ}spi01068
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG10188 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone CG10188 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG10188-RA FBtr0081283  NM_165305   5299   1309 CG10188-RB FBtr0081282  NM_136133   5213   1309
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG10188-PA   FBpp0080821   145.0   1309   7.73     NP_724203   AAN11046 CG10188-PB   FBpp0080820   145.0   1309   7.73     NP_609977   AAF53814
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dbl homology (DH) domain (IPR000219) Pleckstrin homology domain (IPR001849) Pleckstrin homology-type (IPR011993) Rho GTP exchange factor (IPR015721)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA536470   AA536562   AA536575   AE014134 AAF53814   AE014134 AAN11046   AI513673   AW941026   AY128429 AAM75022   BG638127   BI236897   BI238905   BI354619   BI375698   BI636667   BI640998   BI641529   BT031158   CO177812   CO178223   CO178549   CO186686   CO187487   CO265444   CO268215   CO269056   CO270967   CO271899   CO271954   CO272758   CO274221   CO281334   CO282101   CO282320   CO283585   CO290800   CO298672   CO301208   CO303121   CO303632   CO305746   CO313705   CO315713   CO316638   CO318619   CO322463   CO322899   CO326387   EC057055   EC057417   EC059396   EC061321   EC064582   EC066833   EC069761   EC069774   EC071914   EC072061   EC077095   EC081944   EC082553   EC083048   EC085360   EC085681   EC088178   EC199303   EC199548   EC200534   EC201926   EC203064   EC203469   EC203926   EC208645   EC208782   EC212570   EC215384   EC232381   EC237572   EC242828   EC245176   EC245391   EC255628   EC257508   EV588389   FE426511   FE426530   FE426546   FE862684   FE862738   FE863206   GH764624   GH765128   GH942062   GH943391   GH943470   GH944685   GH944922   GH947041   GH947402   GH947948   GH948355   GH950184   GH950872   GH953699   GH953868   GH953951   GH955171   GH957499   GH957508   GH958280   GH959585   GH960317   GH960691   GH961108   GH962912   GH963515   GH964045   GH964928   GH965487   GH966459   GH966540   GH969071   GH969772   GH970484   GH971284   GH971575   GH974097   GH974512   GH974601   GH975013   GH975892   GH976351   GH977644   GH977692   GH978631   GH979803   GH979854   GH980764   GH981665   GH982954   GH984041   GH984666   GH984844   GH985046
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MQR4 Q9VIV0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032796    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032796 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032796 expression level Developmental Stage   Expression Level embryo 00-02hr    3168 embryo 02-04hr    1841 embryo 04-06hr    2430 embryo 06-08hr    1526 embryo 08-10hr    1315 embryo 10-12hr    1076 embryo 12-14hr    1362 embryo 14-16hr    1404 embryo 16-18hr    842 embryo 18-20hr    758 embryo 20-22hr    602 embryo 22-24hr    662 larva L1    459 larva L2    466 larva L3 12hr old    235 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    465 larva L3 puffstage 7-9    546 white prepupae new    570 white prepupae 12hr    993 white prepupae 24hr    961 pupae 2d postWPP    1113 pupae 3d postWPP    474 pupae 4d postWPP    646 adult male 01day    462 adult male 05day    410 adult male 30day    421 adult female 01day    1024 adult female 05day    1620 adult female 30day    1800 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3168) embryo 02-04hr  (1841) embryo 04-06hr  (2430) embryo 06-08hr  (1526) embryo 08-10hr  (1315) embryo 10-12hr  (1076) embryo 12-14hr  (1362) embryo 14-16hr  (1404) embryo 16-18hr  (842) embryo 18-20hr  (758) embryo 20-22hr  (602) embryo 22-24hr  (662) larva L1  (459) larva L2  (466) larva L3 12hr old  (235) larva L3 puffstage 1-2  (260) larva L3 puffstage 3-6  (465) larva L3 puffstage 7-9  (546) white prepupae new  (570) white prepupae 12hr  (993) white prepupae 24hr  (961) pupae 2d postWPP  (1113) pupae 3d postWPP  (474) pupae 4d postWPP  (646) adult male 01day  (462) adult male 05day  (410) adult male 30day  (421) adult female 01day  (1024) adult female 05day  (1620) adult female 30day  (1800) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3168) embryo 02-04hr  (1841) embryo 04-06hr  (2430) embryo 06-08hr  (1526) embryo 08-10hr    1315 embryo 10-12hr    1076 embryo 12-14hr    1362 embryo 14-16hr  1404 embryo 16-18hr    842 embryo 18-20hr    758 embryo 20-22hr    602 embryo 22-24hr    662 larva L1    459 larva L2    466 larva L3 12hr old    235 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    465 larva L3 puffstage 7-9    546 white prepupae new    570 white prepupae 12hr    993 white prepupae 24hr    961 pupae 2d postWPP    1113 pupae 3d postWPP    474 pupae 4d postWPP    646 adult male 01day    462 adult male 05day    410 adult male 30day    421 adult female 01day    1024 adult female 05day  (1620) adult female 30day  (1800) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3168 embryo 02-04hr    1841 embryo 04-06hr    2430 embryo 06-08hr    1526 embryo 08-10hr    1315 embryo 10-12hr    1076 embryo 12-14hr    1362 embryo 14-16hr    1404 embryo 16-18hr    842 embryo 18-20hr    758 embryo 20-22hr    602 embryo 22-24hr    662 larva L1    459 larva L2    466 larva L3 12hr old    235 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    465 larva L3 puffstage 7-9    546 white prepupae new    570 white prepupae 12hr    993 white prepupae 24hr    961 pupae 2d postWPP    1113 pupae 3d postWPP    474 pupae 4d postWPP    646 adult male 01day    462 adult male 05day    410 adult male 30day    421 adult female 01day    1024 adult female 05day    1620 adult female 30day    1800 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3168 embryo 02-04hr    1841 embryo 04-06hr    2430 embryo 06-08hr    1526 embryo 08-10hr    1315 embryo 10-12hr    1076 embryo 12-14hr    1362 embryo 14-16hr    1404 embryo 16-18hr    842 embryo 18-20hr    758 embryo 20-22hr    602 embryo 22-24hr    662 larva L1    459 larva L2    466 larva L3 12hr old    235 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    465 larva L3 puffstage 7-9    546 white prepupae new    570 white prepupae 12hr    993 white prepupae 24hr    961 pupae 2d postWPP    1113 pupae 3d postWPP    474 pupae 4d postWPP    646 adult male 01day    462 adult male 05day    410 adult male 30day    421 adult female 01day    1024 adult female 05day    1620 adult female 30day    1800 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032796 expression level Developmental Stage   Expression Level embryo 00-02hr    3168 embryo 02-04hr    1841 embryo 04-06hr    2430 embryo 06-08hr    1526 embryo 08-10hr    1315 embryo 10-12hr    1076 embryo 12-14hr    1362 embryo 14-16hr    1404 embryo 16-18hr    842 embryo 18-20hr    758 embryo 20-22hr    602 embryo 22-24hr    662 larva L1    459 larva L2    466 larva L3 12hr old    235 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    465 larva L3 puffstage 7-9    546 white prepupae new    570 white prepupae 12hr    993 white prepupae 24hr    961 pupae 2d postWPP    1113 pupae 3d postWPP    474 pupae 4d postWPP    646 adult male 01day    462 adult male 05day    410 adult male 30day    421 adult female 01day    1024 adult female 05day    1620 adult female 30day    1800 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3168) embryo 02-04hr  (1841) embryo 04-06hr  (2430) embryo 06-08hr  (1526) embryo 08-10hr  (1315) embryo 10-12hr  (1076) embryo 12-14hr  (1362) embryo 14-16hr  (1404) embryo 16-18hr  (842) embryo 18-20hr  (758) embryo 20-22hr  (602) embryo 22-24hr  (662) larva L1  (459) larva L2  (466) larva L3 12hr old  (235) larva L3 puffstage 1-2  (260) larva L3 puffstage 3-6  (465) larva L3 puffstage 7-9  (546) white prepupae new  (570) white prepupae 12hr  (993) white prepupae 24hr  (961) pupae 2d postWPP  (1113) pupae 3d postWPP  (474) pupae 4d postWPP  (646) adult male 01day  (462) adult male 05day  (410) adult male 30day  (421) adult female 01day  (1024) adult female 05day  (1620) adult female 30day  (1800) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3168) embryo 02-04hr  1841 embryo 04-06hr  2430 embryo 06-08hr  1526 embryo 08-10hr    1315 embryo 10-12hr    1076 embryo 12-14hr    1362 embryo 14-16hr  1404 embryo 16-18hr    842 embryo 18-20hr    758 embryo 20-22hr    602 embryo 22-24hr    662 larva L1    459 larva L2    466 larva L3 12hr old    235 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    465 larva L3 puffstage 7-9    546 white prepupae new    570 white prepupae 12hr    993 white prepupae 24hr    961 pupae 2d postWPP    1113 pupae 3d postWPP    474 pupae 4d postWPP    646 adult male 01day    462 adult male 05day    410 adult male 30day    421 adult female 01day    1024 adult female 05day  1620 adult female 30day  1800 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3168 embryo 02-04hr    1841 embryo 04-06hr    2430 embryo 06-08hr    1526 embryo 08-10hr    1315 embryo 10-12hr    1076 embryo 12-14hr    1362 embryo 14-16hr    1404 embryo 16-18hr    842 embryo 18-20hr    758 embryo 20-22hr    602 embryo 22-24hr    662 larva L1    459 larva L2    466 larva L3 12hr old    235 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    465 larva L3 puffstage 7-9    546 white prepupae new    570 white prepupae 12hr    993 white prepupae 24hr    961 pupae 2d postWPP    1113 pupae 3d postWPP    474 pupae 4d postWPP    646 adult male 01day    462 adult male 05day    410 adult male 30day    421 adult female 01day    1024 adult female 05day    1620 adult female 30day    1800 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3168 embryo 02-04hr    1841 embryo 04-06hr    2430 embryo 06-08hr    1526 embryo 08-10hr    1315 embryo 10-12hr    1076 embryo 12-14hr    1362 embryo 14-16hr    1404 embryo 16-18hr    842 embryo 18-20hr    758 embryo 20-22hr    602 embryo 22-24hr    662 larva L1    459 larva L2    466 larva L3 12hr old    235 larva L3 puffstage 1-2    260 larva L3 puffstage 3-6    465 larva L3 puffstage 7-9    546 white prepupae new    570 white prepupae 12hr    993 white prepupae 24hr    961 pupae 2d postWPP    1113 pupae 3d postWPP    474 pupae 4d postWPP    646 adult male 01day    462 adult male 05day    410 adult male 30day    421 adult female 01day    1024 adult female 05day    1620 adult female 30day    1800 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032796    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032796 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult brain. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval Malpighian tubules, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032796 expression level Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    113.7 Larval Hindgut    107.4 Larval Malpighian Tubules    112.6 Larval Fat Body    90.8 Larval Salivary Gland    244.8 Larval Trachea    200.875 Larval Carcass    121.75 Adult Head    312.6 Adult Eye    550.925 Adult Brain    685.6 Adult Thoracic-Abdominal Ganglion    374.5 Adult Crop    97.5 Adult Midgut    118 Adult Hindgut    87.9 Adult Malpighian Tubules    74.7 Adult Fat Body    66.7 Adult Salivary Gland    133.8 Adult Heart    67.375 Adult VirginFemale Spermatheca    254 Adult InseminatedFemale Spermatheca    280.5 Adult Ovary    236.5 Adult Testis no informative data Adult Male Accessory Gland    115.6 Adult Carcass    58.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    113.7 Larval Hindgut    107.4 Larval Malpighian Tubules    112.6 Larval Fat Body    90.8 Larval Salivary Gland    244.8 Larval Trachea    200.875 Larval Carcass    121.75 Adult Head    312.6 Adult Eye  (550.925) Adult Brain  (685.6) Adult Thoracic-Abdominal Ganglion    374.5 Adult Crop    97.5 Adult Midgut    118 Adult Hindgut    87.9 Adult Malpighian Tubules    74.7 Adult Fat Body    66.7 Adult Salivary Gland    133.8 Adult Heart    67.375 Adult VirginFemale Spermatheca    254 Adult InseminatedFemale Spermatheca    280.5 Adult Ovary    236.5 Adult Testis no informative data Adult Male Accessory Gland    115.6 Adult Carcass    58.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    113.7 Larval Hindgut    107.4 Larval Malpighian Tubules    112.6 Larval Fat Body    90.8 Larval Salivary Gland    244.8 Larval Trachea    200.875 Larval Carcass    121.75 Adult Head    312.6 Adult Eye    550.925 Adult Brain    685.6 Adult Thoracic-Abdominal Ganglion    374.5 Adult Crop    97.5 Adult Midgut    118 Adult Hindgut    87.9 Adult Malpighian Tubules    74.7 Adult Fat Body    66.7 Adult Salivary Gland    133.8 Adult Heart    67.375 Adult VirginFemale Spermatheca    254 Adult InseminatedFemale Spermatheca    280.5 Adult Ovary    236.5 Adult Testis no informative data Adult Male Accessory Gland    115.6 Adult Carcass    58.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    113.7 Larval Hindgut    107.4 Larval Malpighian Tubules    112.6 Larval Fat Body    90.8 Larval Salivary Gland    244.8 Larval Trachea    200.875 Larval Carcass    121.75 Adult Head    312.6 Adult Eye    550.925 Adult Brain    685.6 Adult Thoracic-Abdominal Ganglion    374.5 Adult Crop    97.5 Adult Midgut    118 Adult Hindgut    87.9 Adult Malpighian Tubules    74.7 Adult Fat Body    66.7 Adult Salivary Gland    133.8 Adult Heart    67.375 Adult VirginFemale Spermatheca    254 Adult InseminatedFemale Spermatheca    280.5 Adult Ovary    236.5 Adult Testis no informative data Adult Male Accessory Gland    115.6 Adult Carcass    58.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032796 expression level Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    113.7 Larval Hindgut    107.4 Larval Malpighian Tubules    112.6 Larval Fat Body    90.8 Larval Salivary Gland    244.8 Larval Trachea    200.875 Larval Carcass    121.75 Adult Head    312.6 Adult Eye    550.925 Adult Brain    685.6 Adult Thoracic-Abdominal Ganglion    374.5 Adult Crop    97.5 Adult Midgut    118 Adult Hindgut    87.9 Adult Malpighian Tubules    74.7 Adult Fat Body    66.7 Adult Salivary Gland    133.8 Adult Heart    67.375 Adult VirginFemale Spermatheca    254 Adult InseminatedFemale Spermatheca    280.5 Adult Ovary    236.5 Adult Testis no informative data Adult Male Accessory Gland    115.6 Adult Carcass    58.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    113.7 Larval Hindgut    107.4 Larval Malpighian Tubules    112.6 Larval Fat Body    90.8 Larval Salivary Gland    244.8 Larval Trachea    200.875 Larval Carcass    121.75 Adult Head    312.6 Adult Eye  550.925 Adult Brain  685.6 Adult Thoracic-Abdominal Ganglion    374.5 Adult Crop    97.5 Adult Midgut    118 Adult Hindgut    87.9 Adult Malpighian Tubules    74.7 Adult Fat Body    66.7 Adult Salivary Gland    133.8 Adult Heart    67.375 Adult VirginFemale Spermatheca    254 Adult InseminatedFemale Spermatheca    280.5 Adult Ovary    236.5 Adult Testis no informative data Adult Male Accessory Gland    115.6 Adult Carcass    58.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    113.7 Larval Hindgut    107.4 Larval Malpighian Tubules    112.6 Larval Fat Body    90.8 Larval Salivary Gland    244.8 Larval Trachea    200.875 Larval Carcass    121.75 Adult Head    312.6 Adult Eye    550.925 Adult Brain    685.6 Adult Thoracic-Abdominal Ganglion    374.5 Adult Crop    97.5 Adult Midgut    118 Adult Hindgut    87.9 Adult Malpighian Tubules    74.7 Adult Fat Body    66.7 Adult Salivary Gland    133.8 Adult Heart    67.375 Adult VirginFemale Spermatheca    254 Adult InseminatedFemale Spermatheca    280.5 Adult Ovary    236.5 Adult Testis no informative data Adult Male Accessory Gland    115.6 Adult Carcass    58.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    113.7 Larval Hindgut    107.4 Larval Malpighian Tubules    112.6 Larval Fat Body    90.8 Larval Salivary Gland    244.8 Larval Trachea    200.875 Larval Carcass    121.75 Adult Head    312.6 Adult Eye    550.925 Adult Brain    685.6 Adult Thoracic-Abdominal Ganglion    374.5 Adult Crop    97.5 Adult Midgut    118 Adult Hindgut    87.9 Adult Malpighian Tubules    74.7 Adult Fat Body    66.7 Adult Salivary Gland    133.8 Adult Heart    67.375 Adult VirginFemale Spermatheca    254 Adult InseminatedFemale Spermatheca    280.5 Adult Ovary    236.5 Adult Testis no informative data Adult Male Accessory Gland    115.6 Adult Carcass    58.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    312.6   NA  Eye    550.925   NA  Brain    685.6   306.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    374.5   NA  Crop    97.5   113.7  Midgut    118   107.4  Hindgut    87.9   112.6  Malpighian Tubules    74.7   90.8  Fat Body    66.7   244.8  Salivary Gland    133.8   NA  Heart    67.375   200.875  Trachea    NA   NA  VirginFemale Spermatheca    254   NA  InseminatedFemale Spermatheca    280.5   NA  Ovary    236.5   NA  Testis    no informative data   NA  Male Accessory Gland    115.6   121.75  Carcass    58.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032796 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10188-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG10188GD6891 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG10188 Class Mutagen Stocks Known lesion CG10188DG23408 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG10188 Class Mutagen Stocks Known lesion CG10188GD6891 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG10188HMS00713 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG10188KK100404 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7076 (Ryder, 2004.4.26) Df(2L)Exel8041 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6891} NA P{KK100404} NA P{TRiP.HMS00713} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{wHy}CG10188DG23408 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
Rho guanyl-nucleotide exchange factor activity inferred from sequence or structural similarity with EMBL:U73199 (FlyBase, 1992-)
Biological Process
CV term Evidence References
regulation of Rho protein signal transduction inferred from electronic annotation with InterPro:IPR000219 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR000219 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG10188 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61214 DroID - A comprehensive database of gene and protein interactions. • FBgn0032796 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35237
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15628 Dere\GG21626 Dgri\GH10623 Dmoj\GI19769 Dper\GL21097 Dpse\GA10141 Dsec\GM17004 Dvir\GJ18094 Dwil\GK18200 Dyak\GE12646
Curated drosophilid orthologs	Dpse\GA10141
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013487-PA Aedes aegypti (mosquito) AGAP007712-PA Anopheles gambiae (mosquito) XP_395607.3 Apis mellifera (honey bee) XP_001943722.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000014311 Bos taurus (bovine) CN02028 Caenorhabditis brenneri (small nematode) CBP19709 Caenorhabditis briggsae (nematode) CE29842 Caenorhabditis elegans (worm) ENSCAFP00000026914 Canis familiaris (dog) CPIJ011504 Culex pipens (mosquito) ENSCPOP00000000145 Cavia porcellus (guinea pig) RP22891 Caenorhabditis remanei (nematode) 240350 Daphnia pulex (daphnia) ENSDARP00000010740 Danio rerio (zebra fish) ENSGACP00000013837 Gymnopilus aculeatus (mushroom) ENSGALP00000005645 Gallus gallus (chicken) ENSP00000352995 Homo sapiens (human) ISCW008875-PA Ixodes scapularis (deer tick) ENSMODP00000035153 Monodelphis domestica (gray opossum) ENSMMUP00000011024 Macaca mulatta (rhesus monkey) ENSMUSP00000004684 Mus musculus (house mouse) 217462 Nematostella vectensis (starlet anemone) XP_001605530.1 Nasonia vitripennis (wasp) ENSOANP00000015252 Ornithorynchus anatinus (platypus) ENSORLP00000022506 Oryzias latipes (japanese killifish) PHUM000791-PA Pediculus humanus (human body louse) ENSPPYP00000010621 Pongo pygmaeus (orangutan) ENSPTRP00000043575 Pan troglodytes (chimpanzee) ENSRNOP00000001284 Rattus norvegicus (norway rat) XP_001192470.1 Strongylocentrotus purpuratus (purple sea urchin) 54348 Trichoplax adhaerens (metazoa) XP_967832.2 Tribolium castaneum (red flour beetle) ENSTNIP00000018590 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000038706 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000014110 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14447 LH25043 FBgn0230374 FBgn0220199 FBgn0205259 FBgn0193174 FBgn0171917 JGI_V11_240350 FBgn0070200 FBgn0158692 FBgn0142506 FBgn0118104 FBgn0113804 FBgn0092652 CPIJ011504 BGIBMGA013771 ACYPI009576 ACYPI003256 GB18941 AGAP007712 AAEL013487 PB21581 PHUM042890 GLEAN_09420
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	20466 y1 w67c23; P{wHy}CG10188DG23408 33047 y1 sc* v1; P{TRiP.HMS00713}attP2
VDRC	v103391 P{KK100404}VIE-260B v18029 w1118; P{GD6891}v18029
Genomic Clones ( 1 )
	BACR27M12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 136 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH26723 RE41213
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM27630 LD17321 LD17336 RE33026 RE42026 RE63562 SD18434 SD24057 SD24892
Other clones	284 9133 10126 12524 31927 39617 44049 44182 53450 58230 61973 73602 83790 97404 107906 120070 121548 146696 159322 162199 172523 214503.28 214571.29 CK01.17D.F4 CK01.24D.D9 CK01.70C.D1 CK01.71D.H7 CK01.99C.D4 CK01.107B.G8 CK01.107D.E5 CK01.122B.C12 CK01.125A.F2 CK01.132D.D3 Dmel_neb_007531_0163_0947 EK022211 EK030006 EK054348 EK056113 EK057022 EK075208 EK090619 EK093442 EK101214 EK105064 EK105304 EK108264 EK113563 EK142662 EK156719 EK159530 EK160220 EK163719 EK173455 EK180427 EK188203 EK189153 EK233763 EK240053 EK242253 EK249339 EK262264 EK265529 EK273224 EP03827 LD17089 RM05066 RM05266 RM05366 RM06066 RM06166 RM06466 RP001021965 RP001053250 RP004038010 RP004056991 RP004058073 RP004102087 RP004121522 RP004123045 RP004125352 RP004167316 RP004175975 RP004196456 RP004203023 RP004203641 RP004208331 RP004214046 RP004216153 RP004228837 RP004236897 RP004238169 RP004238209 RP004244318 RP004246448 RP004249880 RP004251262 RP004254692 RP004256432 RP004257749 RP004260233 RP004282761 RP004284982 RP004322124 RP004332795 RP004351771 RP004359880 RP004361932 RP004371201 RP004410532 RP004414404 RP004426252 RP004436125 RP004446449 RP004479072 RP004479311 RP004491033 RP004497751 RP004508614 RP004512778 RP004519804 RP004538812 RP004544076 RP004546488 RP004551617 RP004556143
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032796 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35237
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136133 NM_165305 RefSeq (Proteins) • NP_609977 NP_724203 DDBJ / EMBL / GenBank • AAF53814 AAM75022 AAN11046 AI513673 AW941026 AY128429 BI236897 Entrez Gene - A searchable database of RefSeq genes. • 35237 UniProtKB/TrEMBL • Q8MQR4 Q9VIV0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Dbl homology (DH) domain (IPR000219) Pleckstrin homology domain (IPR001849) Pleckstrin homology-type (IPR011993) Rho GTP exchange factor (IPR015721)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61214 DroID - A comprehensive database of gene and protein interactions. • FBgn0032796 DRSC - Results from RNAi screens. • FBgn0032796 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032796 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10188-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032796 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35237 InParanoid A subset of ortholog calls from InParanoid. • AAEL013487-PA Aedes aegypti (mosquito) AGAP007712-PA Anopheles gambiae (mosquito) XP_395607.3 Apis mellifera (honey bee) XP_001943722.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000014311 Bos taurus (bovine) CN02028 Caenorhabditis brenneri (small nematode) CBP19709 Caenorhabditis briggsae (nematode) CE29842 Caenorhabditis elegans (worm) ENSCAFP00000026914 Canis familiaris (dog) CPIJ011504 Culex pipens (mosquito) ENSCPOP00000000145 Cavia porcellus (guinea pig) RP22891 Caenorhabditis remanei (nematode) 240350 Daphnia pulex (daphnia) ENSDARP00000010740 Danio rerio (zebra fish) ENSGACP00000013837 Gymnopilus aculeatus (mushroom) ENSGALP00000005645 Gallus gallus (chicken) ENSP00000352995 Homo sapiens (human) ISCW008875-PA Ixodes scapularis (deer tick) ENSMODP00000035153 Monodelphis domestica (gray opossum) ENSMMUP00000011024 Macaca mulatta (rhesus monkey) ENSMUSP00000004684 Mus musculus (house mouse) 217462 Nematostella vectensis (starlet anemone) XP_001605530.1 Nasonia vitripennis (wasp) ENSOANP00000015252 Ornithorynchus anatinus (platypus) ENSORLP00000022506 Oryzias latipes (japanese killifish) PHUM000791-PA Pediculus humanus (human body louse) ENSPPYP00000010621 Pongo pygmaeus (orangutan) ENSPTRP00000043575 Pan troglodytes (chimpanzee) ENSRNOP00000001284 Rattus norvegicus (norway rat) XP_001192470.1 Strongylocentrotus purpuratus (purple sea urchin) 54348 Trichoplax adhaerens (metazoa) XP_967832.2 Tribolium castaneum (red flour beetle) ENSTNIP00000018590 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000038706 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000014110 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35237 modMine - Data generated by the modENCODE project. • FBgn0032796 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14447 LH25043 FBgn0230374 FBgn0220199 FBgn0205259 FBgn0193174 FBgn0171917 JGI_V11_240350 FBgn0070200 FBgn0158692 FBgn0142506 FBgn0118104 FBgn0113804 FBgn0092652 CPIJ011504 BGIBMGA013771 ACYPI009576 ACYPI003256 GB18941 AGAP007712 AAEL013487 PB21581 PHUM042890 GLEAN_09420
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG10188 (Bakal et al., 2007, Bakal et al., 2007, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Wasbrough et al., 2010)
Name Synonym
Secondary FlyBase IDs
References ( 20 )
Research paper	Bakal et al., 2007, Science 316(5832): 1753--1756 Quantitative morphological signatures define local signaling networks regulating cell morphology. [FBrf0216181] Plank et al., 2005, J. Biol. Chem. 280(5): 3564--3573 Drosophila melanogaster topoisomerase IIIalpha preferentially relaxes a positively or negatively supercoiled bubble substrate and is essential during development. [FBrf0187798]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Bakal et al., 2007, Science 316(5832): Supporting online material. [FBrf0204776] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Gelbart, 2008.3.31, DG.xml DG.xml [FBrf0204101] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Myrick et al., 2005.5.16, Deletion Generator Project genomic insertion collection. Deletion Generator Project genomic insertion collection. [FBrf0188490] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Li, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126682]