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Gene Dmel\CdGAPr

General Information
Symbol	Dmel\CdGAPr	Species	D. melanogaster
Name	CdGAPr	Annotation symbol	CG10538
Feature type	protein_coding_gene	FlyBase ID	FBgn0032821
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	d-CdGAPr, GAP
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	38A3-38A3	Sequence location	2L:19,775,110..19,791,900 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene CdGAPr is referred to in FlyBase by the symbol Dmel\CdGAPr (CG10538, FBgn0032821). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: GTPase activator activity. There is experimental evidence that it is involved in the biological process: retinal ganglion cell axon guidance. 14 alleles are reported. The phenotype of these alleles is annotated with: embryonic/larval optic stalk. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Rho GTPase activation protein; Rho GTPase-activating protein domain; Src homology-3 domain; Variant SH3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1632537_at completely aligns to an exonic region of only a subset of 1 of the 3 FlyBase-annotated transcript isoforms of CdGAPr. Gene sequence location is 2L:19775110..19791900.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA03289 BKN45443 BKN20505
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 38A3-38A3   Limits computationally determined from genome sequence between P{EP}EP623&P{PZ}spi01068 and P{lacW}l(2)k10239k10239
Experimentally Determined Cytological Location
Cytogenetic map Notes References 38A5-38A5     (Sagnier, 1999.12.23)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CdGAPr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone LD 27836 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CdGAPr-RA FBtr0081318  NM_136158   7534   1843 CdGAPr-RB FBtr0300966  NM_001169546   6384   1842 CdGAPr-RC FBtr0300967  NM_001169547   6378   1840
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CdGAPr-PA   FBpp0080851   204.2   1843   7.12     NP_610002   AAF53844 CdGAPr-PB   FBpp0290188   204.1   1842   7.12     NP_001163017   ACZ94303 CdGAPr-PC   FBpp0290189   203.9   1840   7.12     NP_001163018   ACZ94304
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Rho GTPase-activating protein domain (IPR000198) Src homology-3 domain (IPR001452) Rho GTPase activation protein (IPR008936) Variant SH3 (IPR011511)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439369   AA539425   AA949080   AE014134 AAF53844   AE014134 ACZ94303   AE014134 ACZ94304   AF218776 AAF44627   AI531010   AI533527   AI534690   AI534879   AI534907   AI944695   AW942778   AY118541 AAM49910   BE977498   BE978021   BF496273   BF496391   BF501602   BF504145   BG639474   BP555431   BP555432   BT015264 AAT94493   CL528298   CL610245   CO189137   CO263896   CO266387   CO271946   CO285151   CO291264   CO291735   CO304301   CO310466   CO328114   CO344138   CW848242   CZ484715   EC073038   EC081806   EC198390   EC205823   EC214016   EC214436   EC225103   EC232155   EC235466   EC239584   EC241232   EC246264   EC259639   EV578360
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VIS1 E1JHM1 E1JHM0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous & uniform   (Sagnier et al., 2000) Comment:maternally contributed embryonic stage 5   organism | 0-10% egg length   (Sagnier et al., 2000) Comment:confined to posterior pole embryonic stage 6   organism | faint & ubiquitous   (Sagnier et al., 2000) embryonic stage 6 -- 8   cephalic furrow   (Sagnier et al., 2000) ventral neurogenic region   (Sagnier et al., 2000) embryonic stage 9 -- 11   sensory mother cell   (Sagnier et al., 2000) embryonic stage 13 -- 14   embryonic thoracic segment | posterior compartment   (Sagnier et al., 2000) embryonic abdominal segment 1 | posterior compartment   (Sagnier et al., 2000) chordotonal organ precursor cell   (Sagnier et al., 2000) embryonic stage 17   epidermis | posterior & restricted   (Sagnier et al., 2000) Comment:ring of epidermal expression and two pairs bilateral patches at posterior end northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4   organism   (Sagnier et al., 2000) Comment:reference states 0-2 hours third instar larval stage   organism   (Sagnier et al., 2000) adult stage | male   organism   (Sagnier et al., 2000) Comment:both transcripts expressed adult stage | female   organism   (Sagnier et al., 2000)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032821    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032821 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032821 expression level Developmental Stage   Expression Level embryo 00-02hr    2109 embryo 02-04hr    2204 embryo 04-06hr    2619 embryo 06-08hr    2852 embryo 08-10hr    2758 embryo 10-12hr    1742 embryo 12-14hr    2347 embryo 14-16hr    2733 embryo 16-18hr    1703 embryo 18-20hr    1023 embryo 20-22hr    1082 embryo 22-24hr    1167 larva L1    725 larva L2    1024 larva L3 12hr old    478 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    721 larva L3 puffstage 7-9    795 white prepupae new    938 white prepupae 12hr    1306 white prepupae 24hr    1610 pupae 2d postWPP    2985 pupae 3d postWPP    1145 pupae 4d postWPP    560 adult male 01day    893 adult male 05day    1044 adult male 30day    1036 adult female 01day    804 adult female 05day    1203 adult female 30day    1290 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2109) embryo 02-04hr  (2204) embryo 04-06hr  (2619) embryo 06-08hr  (2852) embryo 08-10hr  (2758) embryo 10-12hr  (1742) embryo 12-14hr  (2347) embryo 14-16hr  (2733) embryo 16-18hr  (1703) embryo 18-20hr  (1023) embryo 20-22hr  (1082) embryo 22-24hr  (1167) larva L1  (725) larva L2  (1024) larva L3 12hr old  (478) larva L3 puffstage 1-2  (363) larva L3 puffstage 3-6  (721) larva L3 puffstage 7-9  (795) white prepupae new  (938) white prepupae 12hr  (1306) white prepupae 24hr  (1610) pupae 2d postWPP  (2985) pupae 3d postWPP  (1145) pupae 4d postWPP  (560) adult male 01day  (893) adult male 05day  (1044) adult male 30day  (1036) adult female 01day  (804) adult female 05day  (1203) adult female 30day  (1290) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2109) embryo 02-04hr  (2204) embryo 04-06hr  (2619) embryo 06-08hr  (2852) embryo 08-10hr  (2758) embryo 10-12hr  (1742) embryo 12-14hr  (2347) embryo 14-16hr  (2733) embryo 16-18hr  (1703) embryo 18-20hr    1023 embryo 20-22hr    1082 embryo 22-24hr    1167 larva L1    725 larva L2    1024 larva L3 12hr old    478 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    721 larva L3 puffstage 7-9    795 white prepupae new    938 white prepupae 12hr    1306 white prepupae 24hr  (1610) pupae 2d postWPP  (2985) pupae 3d postWPP    1145 pupae 4d postWPP    560 adult male 01day    893 adult male 05day    1044 adult male 30day    1036 adult female 01day    804 adult female 05day    1203 adult female 30day    1290 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2109 embryo 02-04hr    2204 embryo 04-06hr    2619 embryo 06-08hr    2852 embryo 08-10hr    2758 embryo 10-12hr    1742 embryo 12-14hr    2347 embryo 14-16hr    2733 embryo 16-18hr    1703 embryo 18-20hr    1023 embryo 20-22hr    1082 embryo 22-24hr    1167 larva L1    725 larva L2    1024 larva L3 12hr old    478 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    721 larva L3 puffstage 7-9    795 white prepupae new    938 white prepupae 12hr    1306 white prepupae 24hr    1610 pupae 2d postWPP    2985 pupae 3d postWPP    1145 pupae 4d postWPP    560 adult male 01day    893 adult male 05day    1044 adult male 30day    1036 adult female 01day    804 adult female 05day    1203 adult female 30day    1290 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2109 embryo 02-04hr    2204 embryo 04-06hr    2619 embryo 06-08hr    2852 embryo 08-10hr    2758 embryo 10-12hr    1742 embryo 12-14hr    2347 embryo 14-16hr    2733 embryo 16-18hr    1703 embryo 18-20hr    1023 embryo 20-22hr    1082 embryo 22-24hr    1167 larva L1    725 larva L2    1024 larva L3 12hr old    478 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    721 larva L3 puffstage 7-9    795 white prepupae new    938 white prepupae 12hr    1306 white prepupae 24hr    1610 pupae 2d postWPP    2985 pupae 3d postWPP    1145 pupae 4d postWPP    560 adult male 01day    893 adult male 05day    1044 adult male 30day    1036 adult female 01day    804 adult female 05day    1203 adult female 30day    1290 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032821 expression level Developmental Stage   Expression Level embryo 00-02hr    2109 embryo 02-04hr    2204 embryo 04-06hr    2619 embryo 06-08hr    2852 embryo 08-10hr    2758 embryo 10-12hr    1742 embryo 12-14hr    2347 embryo 14-16hr    2733 embryo 16-18hr    1703 embryo 18-20hr    1023 embryo 20-22hr    1082 embryo 22-24hr    1167 larva L1    725 larva L2    1024 larva L3 12hr old    478 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    721 larva L3 puffstage 7-9    795 white prepupae new    938 white prepupae 12hr    1306 white prepupae 24hr    1610 pupae 2d postWPP    2985 pupae 3d postWPP    1145 pupae 4d postWPP    560 adult male 01day    893 adult male 05day    1044 adult male 30day    1036 adult female 01day    804 adult female 05day    1203 adult female 30day    1290 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2109) embryo 02-04hr  (2204) embryo 04-06hr  (2619) embryo 06-08hr  (2852) embryo 08-10hr  (2758) embryo 10-12hr  (1742) embryo 12-14hr  (2347) embryo 14-16hr  (2733) embryo 16-18hr  (1703) embryo 18-20hr  (1023) embryo 20-22hr  (1082) embryo 22-24hr  (1167) larva L1  (725) larva L2  (1024) larva L3 12hr old  (478) larva L3 puffstage 1-2  (363) larva L3 puffstage 3-6  (721) larva L3 puffstage 7-9  (795) white prepupae new  (938) white prepupae 12hr  (1306) white prepupae 24hr  (1610) pupae 2d postWPP  (2985) pupae 3d postWPP  (1145) pupae 4d postWPP  (560) adult male 01day  (893) adult male 05day  (1044) adult male 30day  (1036) adult female 01day  (804) adult female 05day  (1203) adult female 30day  (1290) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2109 embryo 02-04hr  2204 embryo 04-06hr  (2619) embryo 06-08hr  (2852) embryo 08-10hr  (2758) embryo 10-12hr  1742 embryo 12-14hr  2347 embryo 14-16hr  (2733) embryo 16-18hr  1703 embryo 18-20hr    1023 embryo 20-22hr    1082 embryo 22-24hr    1167 larva L1    725 larva L2    1024 larva L3 12hr old    478 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    721 larva L3 puffstage 7-9    795 white prepupae new    938 white prepupae 12hr    1306 white prepupae 24hr  1610 pupae 2d postWPP  (2985) pupae 3d postWPP    1145 pupae 4d postWPP    560 adult male 01day    893 adult male 05day    1044 adult male 30day    1036 adult female 01day    804 adult female 05day    1203 adult female 30day    1290 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2109 embryo 02-04hr    2204 embryo 04-06hr    2619 embryo 06-08hr    2852 embryo 08-10hr    2758 embryo 10-12hr    1742 embryo 12-14hr    2347 embryo 14-16hr    2733 embryo 16-18hr    1703 embryo 18-20hr    1023 embryo 20-22hr    1082 embryo 22-24hr    1167 larva L1    725 larva L2    1024 larva L3 12hr old    478 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    721 larva L3 puffstage 7-9    795 white prepupae new    938 white prepupae 12hr    1306 white prepupae 24hr    1610 pupae 2d postWPP    2985 pupae 3d postWPP    1145 pupae 4d postWPP    560 adult male 01day    893 adult male 05day    1044 adult male 30day    1036 adult female 01day    804 adult female 05day    1203 adult female 30day    1290 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2109 embryo 02-04hr    2204 embryo 04-06hr    2619 embryo 06-08hr    2852 embryo 08-10hr    2758 embryo 10-12hr    1742 embryo 12-14hr    2347 embryo 14-16hr    2733 embryo 16-18hr    1703 embryo 18-20hr    1023 embryo 20-22hr    1082 embryo 22-24hr    1167 larva L1    725 larva L2    1024 larva L3 12hr old    478 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    721 larva L3 puffstage 7-9    795 white prepupae new    938 white prepupae 12hr    1306 white prepupae 24hr    1610 pupae 2d postWPP    2985 pupae 3d postWPP    1145 pupae 4d postWPP    560 adult male 01day    893 adult male 05day    1044 adult male 30day    1036 adult female 01day    804 adult female 05day    1203 adult female 30day    1290 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032821    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032821 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032821 expression level Tissue   Expression Level Larval Central Nervous System    18.6 Larval Midgut    0.9 Larval Hindgut    3.4 Larval Malpighian Tubules    1.1 Larval Fat Body    0.4 Larval Salivary Gland    2.7 Larval Trachea    5.45 Larval Carcass    2.675 Adult Head    3.8 Adult Eye    8.375 Adult Brain    12.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.8 Adult Midgut    0.3 Adult Hindgut    1.6 Adult Malpighian Tubules    1 Adult Fat Body    3.3 Adult Salivary Gland    2.2 Adult Heart    3.4 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    0.9 Adult Testis    1.7 Adult Male Accessory Gland    3.4 Adult Carcass    2.4 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    18.6 Larval Midgut    0.9 Larval Hindgut    3.4 Larval Malpighian Tubules    1.1 Larval Fat Body    0.4 Larval Salivary Gland    2.7 Larval Trachea    5.45 Larval Carcass    2.675 Adult Head    3.8 Adult Eye    8.375 Adult Brain    12.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.8 Adult Midgut    0.3 Adult Hindgut    1.6 Adult Malpighian Tubules    1 Adult Fat Body    3.3 Adult Salivary Gland    2.2 Adult Heart    3.4 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    0.9 Adult Testis    1.7 Adult Male Accessory Gland    3.4 Adult Carcass    2.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    18.6 Larval Midgut    0.9 Larval Hindgut    3.4 Larval Malpighian Tubules    1.1 Larval Fat Body    0.4 Larval Salivary Gland    2.7 Larval Trachea    5.45 Larval Carcass    2.675 Adult Head    3.8 Adult Eye    8.375 Adult Brain    12.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.8 Adult Midgut    0.3 Adult Hindgut    1.6 Adult Malpighian Tubules    1 Adult Fat Body    3.3 Adult Salivary Gland    2.2 Adult Heart    3.4 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    0.9 Adult Testis    1.7 Adult Male Accessory Gland    3.4 Adult Carcass    2.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    18.6 Larval Midgut    0.9 Larval Hindgut    3.4 Larval Malpighian Tubules    1.1 Larval Fat Body    0.4 Larval Salivary Gland    2.7 Larval Trachea    5.45 Larval Carcass    2.675 Adult Head    3.8 Adult Eye    8.375 Adult Brain    12.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.8 Adult Midgut    0.3 Adult Hindgut    1.6 Adult Malpighian Tubules    1 Adult Fat Body    3.3 Adult Salivary Gland    2.2 Adult Heart    3.4 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    0.9 Adult Testis    1.7 Adult Male Accessory Gland    3.4 Adult Carcass    2.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032821 expression level Tissue   Expression Level Larval Central Nervous System    18.6 Larval Midgut    0.9 Larval Hindgut    3.4 Larval Malpighian Tubules    1.1 Larval Fat Body    0.4 Larval Salivary Gland    2.7 Larval Trachea    5.45 Larval Carcass    2.675 Adult Head    3.8 Adult Eye    8.375 Adult Brain    12.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.8 Adult Midgut    0.3 Adult Hindgut    1.6 Adult Malpighian Tubules    1 Adult Fat Body    3.3 Adult Salivary Gland    2.2 Adult Heart    3.4 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    0.9 Adult Testis    1.7 Adult Male Accessory Gland    3.4 Adult Carcass    2.4 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    18.6 Larval Midgut    0.9 Larval Hindgut    3.4 Larval Malpighian Tubules    1.1 Larval Fat Body    0.4 Larval Salivary Gland    2.7 Larval Trachea    5.45 Larval Carcass    2.675 Adult Head    3.8 Adult Eye    8.375 Adult Brain    12.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.8 Adult Midgut    0.3 Adult Hindgut    1.6 Adult Malpighian Tubules    1 Adult Fat Body    3.3 Adult Salivary Gland    2.2 Adult Heart    3.4 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    0.9 Adult Testis    1.7 Adult Male Accessory Gland    3.4 Adult Carcass    2.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    18.6 Larval Midgut    0.9 Larval Hindgut    3.4 Larval Malpighian Tubules    1.1 Larval Fat Body    0.4 Larval Salivary Gland    2.7 Larval Trachea    5.45 Larval Carcass    2.675 Adult Head    3.8 Adult Eye    8.375 Adult Brain    12.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.8 Adult Midgut    0.3 Adult Hindgut    1.6 Adult Malpighian Tubules    1 Adult Fat Body    3.3 Adult Salivary Gland    2.2 Adult Heart    3.4 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    0.9 Adult Testis    1.7 Adult Male Accessory Gland    3.4 Adult Carcass    2.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    18.6 Larval Midgut    0.9 Larval Hindgut    3.4 Larval Malpighian Tubules    1.1 Larval Fat Body    0.4 Larval Salivary Gland    2.7 Larval Trachea    5.45 Larval Carcass    2.675 Adult Head    3.8 Adult Eye    8.375 Adult Brain    12.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.8 Adult Midgut    0.3 Adult Hindgut    1.6 Adult Malpighian Tubules    1 Adult Fat Body    3.3 Adult Salivary Gland    2.2 Adult Heart    3.4 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    0.9 Adult Testis    1.7 Adult Male Accessory Gland    3.4 Adult Carcass    2.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3.8   NA  Eye    8.375   NA  Brain    12.4   18.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    5.8   0.9  Midgut    0.3   3.4  Hindgut    1.6   1.1  Malpighian Tubules    1   0.4  Fat Body    3.3   2.7  Salivary Gland    2.2   NA  Heart    3.4   5.45  Trachea    NA   NA  VirginFemale Spermatheca    2.4   NA  InseminatedFemale Spermatheca    4.4   NA  Ovary    0.9   NA  Testis    1.7   NA  Male Accessory Gland    3.4   2.675  Carcass    2.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032821 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10538-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CdGAPrEY13451 CdGAPrKG10431 Sterility Allele fertile CdGAPrEY13451 CdGAPrKG10431 Other Phenotypes Allele neuroanatomy defective CdGAPrEY13451 CdGAPrNP3053 neuroanatomy defective, with Scer\GAL4CdGAPr-NP3053 CdGAPrdsRNA.Scer\UAS neuroanatomy defective (with CdGAPrEY13451) CdGAPrNP3053 neuroanatomy defective (with CdGAPrNP3053) CdGAPrEY13451 neuroanatomy defective (with Df(2L)ED1303) CdGAPrEY13451 CdGAPrNP3053 Phenotype manifest in Allele embryonic/larval optic stalk CdGAPrEY13451 CdGAPrNP3053 embryonic/larval optic stalk, with Scer\GAL4CdGAPr-NP3053 CdGAPrdsRNA.Scer\UAS embryonic/larval optic stalk (with CdGAPrEY13451) CdGAPrNP3053 embryonic/larval optic stalk (with CdGAPrNP3053) CdGAPrEY13451 embryonic/larval optic stalk (with Df(2L)ED1303) CdGAPrEY13451 CdGAPrNP3053
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of CdGAPr Class Mutagen Stocks Known lesion CdGAPrA248 2 -- CdGAPrEY09626 P-element activity 2 -- CdGAPrCB-6227-3 1 -- CdGAPrEY13451 P-element activity 1 -- CdGAPrf02203 piggyBac transposase 1 -- CdGAPrKG10431 P-element activity 1 -- CdGAPrNP1282 1 -- CdGAPrNP2334 1 -- CdGAPrNP3053 loss of function allele 1 Yes CdGAPrdsRNA.H.Scer\UAS 0 -- CdGAPrPw+5 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CdGAPr Class Mutagen Stocks Known lesion CdGAPrdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 2 Yes CdGAPrGD6570 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CdGAPrKK100409 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6045 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6570} NA P{KK100409} NA P{UAS-CdGAPr-dsRNA} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS3}CdGAPrCB-6227-3 NA P{SUPor-P}CdGAPrKG10431 NA PBac{5HPw+}CdGAPrA248 NA PBac{PB}c05413 NA PBac{WH}CdGAPrf02203 NA insertion of mobile activating element P{EPgy2}CdGAPrEY09626 NA P{EPgy2}CdGAPrEY13451 NA insertion of enhancer trap P{lacW}CdGAPrPw+5 No P{lacW}l(2)SH2280SH2280 No insertion of enhancer trap binary system P{GawB}CdGAPrNP1282 No P{GawB}CdGAPrNP2334 No P{GawB}CdGAPrNP3053 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
retinal ganglion cell axon guidance inferred from mutant phenotype (assigned by UniProtKB) (Murakami et al., 2007, Sagnier et al., 2000)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
GTPase activator activity inferred from sequence or structural similarity (Sagnier, 1999.12.23) inferred from sequence or structural similarity with Saccharomyces RGA1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
signal transduction inferred from electronic annotation with InterPro:IPR000198, InterPro:IPR008936 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR000198, InterPro:IPR008936 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CdGAPr allele Gene References unspecified Fak56D (Murakami et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61243 DroID - A comprehensive database of gene and protein interactions. • FBgn0032821 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35267
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15474 Dere\GG21607 Dgri\GH13043 Dmoj\GI18189 Dper\GL25619 Dpse\GA10382 Dsec\GM16986 Dsim\GD21733 Dvir\GJ14675 Dwil\GK15216 Dyak\GE12627
Curated drosophilid orthologs	Dpse\GA10382   Dsim\GD21733 (Findlay et al., 2009)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007240-PA Aedes aegypti (mosquito) AGAP009303-PA Anopheles gambiae (mosquito) XP_624644.1 Apis mellifera (honey bee) XP_001943121.1 Acyrthosiphon pisum (pea aphid) BGIBMGA011353-PA Bombyx mori (silk worm) ENSBTAP00000012813 Bos taurus (bovine) CPIJ012517 Culex pipens (mosquito) ENSECAP00000017004 Equus caballus (horse) ENSGACP00000026655 Gymnopilus aculeatus (mushroom) ENSP00000264344 Homo sapiens (human) ISCW023139-PA Ixodes scapularis (deer tick) ENSMODP00000017552 Monodelphis domestica (gray opossum) ENSMUSP00000048601 Mus musculus (house mouse) XP_001606950.1 Nasonia vitripennis (wasp) PHUM003013-PA Pediculus humanus (human body louse) XP_968224.2 Tribolium castaneum (red flour beetle) ENSTNIP00000014582 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014730 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000038109 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10236 LH24483 ISCW023139 FBgn0230355 FBgn0217221 FBgn0201882 FBgn0193155 FBgn0171899 JGI_V11_46980 FBgn0070439 FBgn0163203 FBgn0140928 FBgn0120520 FBgn0113785 FBgn0092499 CPIJ012517 BGIBMGA011353 ACYPI004995 GB18281 AGAP009303 AAEL007240 PB24956 PHUM288580 GLEAN_06051
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	16527 y1; P{SUPor-P}CdGAPrKG10431 6437 y1 w*; P{UAS-CdGAPr-dsRNA}6.1 6438 y1 w*; P{UAS-CdGAPr-dsRNA}3.1 21418 y1 w67c23; P{EPgy2}CdGAPrEY13451 20045 y1 w67c23; P{EPgy2}CdGAPrEY09626/CyO 16078 y1 w1118; PBac{5HPw+}CdGAPrA248/CyO
Harvard	- PBac{WH}CdGAPrf02203
Kyoto	104357 w*; P{GawB}CdGAPrNP3053 123985 w1118; P{RS3}CdGAPrCB-6227-3 112889 w*; P{GawB}CdGAPrNP2334 / CyO 103967 y* w*; P{GawB}CdGAPrNP1282 / CyO, P{UAS-lacZ.UW14}UW14 114580 yd2 w1118 P{ey-FLP.N}2; P{EPgy2}CdGAPrEY09626 P{neoFRT}40A/CyO y+
	More stocks available...
Genomic Clones ( 1 )
	BACR48M05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 42 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD27836 LD38535
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05445 AT10035 AT10179 AT16974 LD13919 LD17545 SD01180 SD01860 SD05383 SD07674
Other clones	87 28798 35587 60159 70445 98999 107287 120778 211006.2 214373.37 bs04c11 bs64g05 bs72d05 CK01.2C.A8 CK01.52D.H11 CK01.97B.E10 Dmel_dig_018101_0628_1726 EK043132 EK076938 EK105249 EK136814 EK146224 EK168351 EK198055 EK221750 EK244311 EP08608 EP18730 FGM235C04 SD01144
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032821 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35267
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: GAP CG10538 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of GAP CG10538 was sequence comparison (date:000327). (FlyBase, 1996-)
Other Comments
	CdGAPr is required for normal optic stalk morphogenesis. (Murakami et al., 2007) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136158 NM_001169546 NM_001169547 RefSeq (Proteins) • NP_610002 NP_001163017 NP_001163018 DDBJ / EMBL / GenBank • AA439369 AA949080 AAF44627 AAF53844 AAM49910 AAT94493 ACZ94303 ACZ94304 AF218776 AI944695 AW942778 AY118541 BT015264 CL528298 CL610245 CW848242 CZ484715 Entrez Gene - A searchable database of RefSeq genes. • 35267 UniProtKB/TrEMBL • E1JHM0 E1JHM1 Q9VIS1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Rho GTPase-activating protein domain (IPR000198) Src homology-3 domain (IPR001452) Rho GTPase activation protein (IPR008936) Variant SH3 (IPR011511)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61243 DroID - A comprehensive database of gene and protein interactions. • FBgn0032821 DRSC - Results from RNAi screens. • FBgn0032821 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032821 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10538-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032821 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35267 InParanoid A subset of ortholog calls from InParanoid. • AAEL007240-PA Aedes aegypti (mosquito) AGAP009303-PA Anopheles gambiae (mosquito) XP_624644.1 Apis mellifera (honey bee) XP_001943121.1 Acyrthosiphon pisum (pea aphid) BGIBMGA011353-PA Bombyx mori (silk worm) ENSBTAP00000012813 Bos taurus (bovine) CPIJ012517 Culex pipens (mosquito) ENSECAP00000017004 Equus caballus (horse) ENSGACP00000026655 Gymnopilus aculeatus (mushroom) ENSP00000264344 Homo sapiens (human) ISCW023139-PA Ixodes scapularis (deer tick) ENSMODP00000017552 Monodelphis domestica (gray opossum) ENSMUSP00000048601 Mus musculus (house mouse) XP_001606950.1 Nasonia vitripennis (wasp) PHUM003013-PA Pediculus humanus (human body louse) XP_968224.2 Tribolium castaneum (red flour beetle) ENSTNIP00000014582 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014730 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000038109 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35267 modMine - Data generated by the modENCODE project. • FBgn0032821 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10236 LH24483 ISCW023139 FBgn0230355 FBgn0217221 FBgn0201882 FBgn0193155 FBgn0171899 JGI_V11_46980 FBgn0070439 FBgn0163203 FBgn0140928 FBgn0120520 FBgn0113785 FBgn0092499 CPIJ012517 BGIBMGA011353 ACYPI004995 GB18281 AGAP009303 AAEL007240 PB24956 PHUM288580 GLEAN_06051
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	10538 (Hu, 2005) CdGAPr (Murakami et al., 2007, Bakal et al., 2007, Nir et al., 2010) CG10538 (Hu, 2005, Murakami et al., 2007, Keleman et al., 2009.8.5) d-CdGAPr (Sagnier et al., 2000, Sagnier, 1999.12.23) FBgn 32821 (Lehmann et al., 2010) GAP (FamiliarityBreedsContempt, 1999.11, Li, 1999.11, )
Name Synonym	CdGAPr
Secondary FlyBase IDs
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 8 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Computer file  ( 3 )
Recent research papers ( 2 )
	Lehmann et al., 2010, BMC Evol. Biol. 10: 156 Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication. [FBrf0211127] Nir et al., 2010, Genome Res. 20(3): 372--380 Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. [FBrf0210162] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...