Gene Dmel\CdGAPr

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General Information

Symbol

Dmel\CdGAPr

Species

D. melanogaster

Name

CdGAPr

Annotation symbol

CG10538

Feature type

protein_coding_gene

FlyBase ID

FBgn0032821

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

38A3-38A3

Sequence location

2L:19,775,092..19,791,900 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol CdGAPr (CG10538, FBgn0032821). It has the cytological map location 38A3. Its sequence location is 2L:19775092..19791900. Its molecular function is described as GTPase activator activity. It is involved in the biological process signal transduction. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

38A3-38A3

Limits computationally determined from genome sequence between P{EP}EP623&P{PZ}spi⁰¹⁰⁶⁸ and P{lacW}l(2)k10239^k10239

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

38A5-38A5

(Sagnier, 1999.12.23)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\CdGAPr for information on other features

Comments on Gene Model

DGC clone LD 27836 appears problematic: incomplete CDS

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CdGAPr-RA

FBtr0081318

NM_136158

7552

1843

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CdGAPr-PA

FBpp0080851

204.2

1843

7.12

NP_610002

AAF53844

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0032821

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

RhoGAP (IPR000198)

Src homology-3 (IPR001452)

Rho GTPase activation protein (IPR008936)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

(Oliver, 2001.8.16)

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

8157

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AA949080

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0032821

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0032821

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0032821

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

Sterility

Allele

fertile

Phenotype manifest in

Allele

Classical Alleles ( 6 )

For All Classical Alleles Show

Allele of CdGAPr	Mutagen	Stocks	Known lesion
CdGAPr^EY09626	P-element activity	1	--
CdGAPr^EY13451	P-element activity	1	--
CdGAPr^KG10431	P-element activity	1	--
CdGAPr^Pw+5	P-element activity	0	Yes
CdGAPr^{dsRNA.H.Scer\UAS}		0	--
CdGAPr^f02203	piggyBac transposase	1	--

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CdGAPr	Class	Mutagen	Stocks	Known lesion
CdGAPr^GD6570		in vitro construct \| RNAi in vitro construct \| regulatory fusion	0	Yes
CdGAPr^{dsRNA.Scer\UAS}		in vitro construct \| regulatory fusion in vitro construct \| RNAi	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(2L)TW150

Disrupted in

Df(2L)Exel6045

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD6570}

P{UAS-CdGAPr-dsRNA}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EPgy2}CdGAPr^EY09626

P{EPgy2}CdGAPr^EY13451

miscellaneous insertions

PBac{5HPw⁺}A248

PBac{PB}c05413

PBac{WH}CdGAPr^f02203

P{SUPor-P}CdGAPr^KG10431

insertion of enhancer trap

P{lacW}CdGAPr^Pw+5

P{lacW}l(2)SH2280^SH2280

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 3 )

Molecular Function

CV term

Evidence

References

GTPase activator activity

inferred from sequence or structural similarity

(Sagnier, 1999.12.23)

inferred from sequence or structural similarity with SGD_LOCUS:RGA1; SGD:S0005653

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

signal transduction

inferred from electronic annotation with InterPro:IPR000198, InterPro:IPR008936

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

intracellular

inferred from electronic annotation with InterPro:IPR000198, InterPro:IPR008936

(FlyBase Curators et al., 2004-)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CdGAPr allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

61243

Drosophila PIMRider - The Drosophila Protein Interaction map

•

521612

Orthologs

Genome-wide drosophilid orthologs

Dpse\GA10382

Dana\GF15474

Dere\GG21607

Dgri\GH13043

Dmoj\GI18189

Dper\GL25619

Dsec\GM16986

Dsim\GD21733

Dvir\GJ14675

Dwil\GK15216

Dyak\GE12627

Curated drosophilid orthologs

Dpse\GA10382

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

MGI:2673998
Mus musculus (Informatics)
WBGene00009800
Caenorhabditis elegans (Wormbase)
WBGene00025070
Caenorhabditis briggsae (Wormbase)
AT1G08340.1
Arabidopsis thaliana (Arabidopsis)
ENSXETP00000038104
Xenopus tropicalis (Ensembl)
GSTENP00036578001
Tetraodon nigroviridis (Ensembl)
ENSRNOP00000033946
Rattus norvegicus (Ensembl)
ENSPTRP00000042699
Pan troglodytes (Ensembl)
ENSMODP00000017552
Monodelphis domestica (Ensembl)
ENSP00000320038
Homo sapiens (Ensembl)
ENSGALP00000018113
Gallus gallus (Ensembl)
ENSCINP00000007058
Ciona intestinalis (Ensembl)
ENSBTAP00000012817
Bos taurus (Ensembl)
ENSANGP00000010655
Anopheles gambiae (Ensembl)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 10 )

Harvard

PBac{PB}c05413

PBac{WH}CdGAPr^f02203

Szeged

P{lacW}l(2)SH2280^SH2280

Bloomington

17705

w¹¹¹⁸; PBac{PB}c05413/CyO

16527

y¹; P{SUPor-P}CdGAPr^KG10431

6437

y¹ w^*; P{UAS-CdGAPr-dsRNA}6.1

6438

y¹ w^*; P{UAS-CdGAPr-dsRNA}3.1

16078

y¹ w¹¹¹⁸; PBac{5HPw⁺}A248/CyO

21418

y¹ w^67c23; P{EPgy2}CdGAPr^EY13451

20045

y¹ w^67c23; P{EPgy2}CdGAPr^EY09626/CyO

Genomic Clones ( 1 )

BACR48M05

cDNA Clones ( 22 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0032821

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0032821

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for identity of: GAP CG10538 Source for identity of GAP CG10538 was sequence comparison (date:000327).

(FlyBase, 1996-)

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_136158

RefSeq (Proteins)

•

NP_610002

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

RhoGAP (IPR000198)

Src homology-3 (IPR001452)

Rho GTPase activation protein (IPR008936)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

61243

DEDB - Drosophila exon database: splicing graphs

•

8157

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0032821

Drosophila PIMRider - The Drosophila Protein Interaction map

•

521612

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0032821

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0032821

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0032821

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0032821

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0032821

InParanoid orthologs - Eukaryotic orthologs

•

MGI:2673998
Mus musculus (Informatics)
WBGene00009800
Caenorhabditis elegans (Wormbase)
WBGene00025070
Caenorhabditis briggsae (Wormbase)
AT1G08340.1
Arabidopsis thaliana (Arabidopsis)
ENSXETP00000038104
Xenopus tropicalis (Ensembl)
GSTENP00036578001
Tetraodon nigroviridis (Ensembl)
ENSRNOP00000033946
Rattus norvegicus (Ensembl)
ENSPTRP00000042699
Pan troglodytes (Ensembl)
ENSMODP00000017552
Monodelphis domestica (Ensembl)
ENSP00000320038
Homo sapiens (Ensembl)
ENSGALP00000018113
Gallus gallus (Ensembl)
ENSCINP00000007058
Ciona intestinalis (Ensembl)
ENSBTAP00000012817
Bos taurus (Ensembl)
ENSANGP00000010655
Anopheles gambiae (Ensembl)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0032821

University of Chicago Dev. Expression

•

FBgn0032821

Synonyms & Secondary IDs ( 5 )

Reported As

Symbol Synonym

10538

(Hu et al., 2005)

CdGAPr

CG10538

(Hu, 2005, )

d-CdGAPr

(Sagnier et al., 2000, Sagnier, 1999.12.23)

GAP

(FamiliarityBreedsContempt, 1999.11, Li, 1999.11, )

Name Synonym

CdGAPr

Secondary FlyBase IDs

References ( 21 )

Generate a list of

All references relating to this gene ( 21 )

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Recent research papers (0)

All research papers listed in FlyBase were published before 2006

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Recent reviews (0)

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