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Gene Dmel\Kua

General Information
Symbol	Dmel\Kua	Species	D. melanogaster
Name	Kua	Annotation symbol	CG10723
Feature type	protein_coding_gene	FlyBase ID	FBgn0032850
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	38B.18
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	38C1-38C1	Sequence location	2L:20,097,858..20,103,375 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Kua is referred to in FlyBase by the symbol Dmel\Kua (CG10723, FBgn0032850). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Kua-ubiquitin conjugating enzyme hybrid, localisation. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult Malpighian tubules, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1629215_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Kua. Gene sequence location is 2L:20097858..20103375.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA02100 BKN28655
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 38C1-38C1   Limits computationally determined from genome sequence between P{EP}nebEP642 and P{lacW}k09005
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Kua for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Kua-RA FBtr0081336  NM_136182   1878   310 Kua-RB FBtr0303230  NM_001201927   1878   310
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Kua-PA   FBpp0080868   35.4   310   8.17     NP_610026   AAF53878 Kua-PB   FBpp0292322   35.4   310   8.17     NP_001188856   ADV37105
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Kua-ubiquitin conjugating enzyme hybrid, localisation (IPR019547)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53878   AC004364   AE014134 ADV37105   AF152361 AAF00151   BT029029   BT126266   CO185739   CO339000   EC061538   EL869633   EL869634
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V3B5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032850    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032850 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032850 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    34 embryo 04-06hr    26 embryo 06-08hr    13 embryo 08-10hr    13 embryo 10-12hr    25 embryo 12-14hr    38 embryo 14-16hr    68 embryo 16-18hr    137 embryo 18-20hr    184 embryo 20-22hr    143 embryo 22-24hr    187 larva L1    127 larva L2    46 larva L3 12hr old    65 larva L3 puffstage 1-2    139 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    76 white prepupae new    44 white prepupae 12hr    61 white prepupae 24hr    105 pupae 2d postWPP    153 pupae 3d postWPP    249 pupae 4d postWPP    167 adult male 01day    202 adult male 05day    265 adult male 30day    291 adult female 01day    88 adult female 05day    37 adult female 30day    64 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    34 embryo 04-06hr    26 embryo 06-08hr    13 embryo 08-10hr    13 embryo 10-12hr    25 embryo 12-14hr    38 embryo 14-16hr    68 embryo 16-18hr  (137) embryo 18-20hr  (184) embryo 20-22hr  (143) embryo 22-24hr  (187) larva L1  (127) larva L2    46 larva L3 12hr old    65 larva L3 puffstage 1-2  (139) larva L3 puffstage 3-6  (114) larva L3 puffstage 7-9    76 white prepupae new    44 white prepupae 12hr    61 white prepupae 24hr  105 pupae 2d postWPP  (153) pupae 3d postWPP  (249) pupae 4d postWPP  (167) adult male 01day  (202) adult male 05day  (265) adult male 30day  (291) adult female 01day    88 adult female 05day    37 adult female 30day    64 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    34 embryo 04-06hr    26 embryo 06-08hr    13 embryo 08-10hr    13 embryo 10-12hr    25 embryo 12-14hr    38 embryo 14-16hr    68 embryo 16-18hr    137 embryo 18-20hr    184 embryo 20-22hr    143 embryo 22-24hr    187 larva L1    127 larva L2    46 larva L3 12hr old    65 larva L3 puffstage 1-2    139 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    76 white prepupae new    44 white prepupae 12hr    61 white prepupae 24hr    105 pupae 2d postWPP    153 pupae 3d postWPP    249 pupae 4d postWPP    167 adult male 01day    202 adult male 05day    265 adult male 30day    291 adult female 01day    88 adult female 05day    37 adult female 30day    64 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    34 embryo 04-06hr    26 embryo 06-08hr    13 embryo 08-10hr    13 embryo 10-12hr    25 embryo 12-14hr    38 embryo 14-16hr    68 embryo 16-18hr    137 embryo 18-20hr    184 embryo 20-22hr    143 embryo 22-24hr    187 larva L1    127 larva L2    46 larva L3 12hr old    65 larva L3 puffstage 1-2    139 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    76 white prepupae new    44 white prepupae 12hr    61 white prepupae 24hr    105 pupae 2d postWPP    153 pupae 3d postWPP    249 pupae 4d postWPP    167 adult male 01day    202 adult male 05day    265 adult male 30day    291 adult female 01day    88 adult female 05day    37 adult female 30day    64 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    34 embryo 04-06hr    26 embryo 06-08hr    13 embryo 08-10hr    13 embryo 10-12hr    25 embryo 12-14hr    38 embryo 14-16hr    68 embryo 16-18hr    137 embryo 18-20hr    184 embryo 20-22hr    143 embryo 22-24hr    187 larva L1    127 larva L2    46 larva L3 12hr old    65 larva L3 puffstage 1-2    139 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    76 white prepupae new    44 white prepupae 12hr    61 white prepupae 24hr    105 pupae 2d postWPP    153 pupae 3d postWPP    249 pupae 4d postWPP    167 adult male 01day    202 adult male 05day    265 adult male 30day    291 adult female 01day    88 adult female 05day    37 adult female 30day    64 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032850 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    34 embryo 04-06hr    26 embryo 06-08hr    13 embryo 08-10hr    13 embryo 10-12hr    25 embryo 12-14hr    38 embryo 14-16hr    68 embryo 16-18hr    137 embryo 18-20hr    184 embryo 20-22hr    143 embryo 22-24hr    187 larva L1    127 larva L2    46 larva L3 12hr old    65 larva L3 puffstage 1-2    139 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    76 white prepupae new    44 white prepupae 12hr    61 white prepupae 24hr    105 pupae 2d postWPP    153 pupae 3d postWPP    249 pupae 4d postWPP    167 adult male 01day    202 adult male 05day    265 adult male 30day    291 adult female 01day    88 adult female 05day    37 adult female 30day    64 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    34 embryo 04-06hr    26 embryo 06-08hr    13 embryo 08-10hr    13 embryo 10-12hr    25 embryo 12-14hr    38 embryo 14-16hr    68 embryo 16-18hr  137 embryo 18-20hr  (184) embryo 20-22hr  143 embryo 22-24hr  (187) larva L1  127 larva L2    46 larva L3 12hr old    65 larva L3 puffstage 1-2  139 larva L3 puffstage 3-6  114 larva L3 puffstage 7-9    76 white prepupae new    44 white prepupae 12hr    61 white prepupae 24hr  105 pupae 2d postWPP  (153) pupae 3d postWPP  (249) pupae 4d postWPP  (167) adult male 01day  (202) adult male 05day  (265) adult male 30day  (291) adult female 01day    88 adult female 05day    37 adult female 30day    64 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    34 embryo 04-06hr    26 embryo 06-08hr    13 embryo 08-10hr    13 embryo 10-12hr    25 embryo 12-14hr    38 embryo 14-16hr    68 embryo 16-18hr    137 embryo 18-20hr    184 embryo 20-22hr    143 embryo 22-24hr    187 larva L1    127 larva L2    46 larva L3 12hr old    65 larva L3 puffstage 1-2    139 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    76 white prepupae new    44 white prepupae 12hr    61 white prepupae 24hr    105 pupae 2d postWPP    153 pupae 3d postWPP    249 pupae 4d postWPP    167 adult male 01day    202 adult male 05day    265 adult male 30day    291 adult female 01day    88 adult female 05day    37 adult female 30day    64 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    34 embryo 04-06hr    26 embryo 06-08hr    13 embryo 08-10hr    13 embryo 10-12hr    25 embryo 12-14hr    38 embryo 14-16hr    68 embryo 16-18hr    137 embryo 18-20hr    184 embryo 20-22hr    143 embryo 22-24hr    187 larva L1    127 larva L2    46 larva L3 12hr old    65 larva L3 puffstage 1-2    139 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    76 white prepupae new    44 white prepupae 12hr    61 white prepupae 24hr    105 pupae 2d postWPP    153 pupae 3d postWPP    249 pupae 4d postWPP    167 adult male 01day    202 adult male 05day    265 adult male 30day    291 adult female 01day    88 adult female 05day    37 adult female 30day    64 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    34 embryo 04-06hr    26 embryo 06-08hr    13 embryo 08-10hr    13 embryo 10-12hr    25 embryo 12-14hr    38 embryo 14-16hr    68 embryo 16-18hr    137 embryo 18-20hr    184 embryo 20-22hr    143 embryo 22-24hr    187 larva L1    127 larva L2    46 larva L3 12hr old    65 larva L3 puffstage 1-2    139 larva L3 puffstage 3-6    114 larva L3 puffstage 7-9    76 white prepupae new    44 white prepupae 12hr    61 white prepupae 24hr    105 pupae 2d postWPP    153 pupae 3d postWPP    249 pupae 4d postWPP    167 adult male 01day    202 adult male 05day    265 adult male 30day    291 adult female 01day    88 adult female 05day    37 adult female 30day    64 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032850    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032850 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult Malpighian tubules, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032850 expression level Tissue   Expression Level Larval Central Nervous System    4.025 Larval Midgut    68.6 Larval Hindgut    23.1 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    5.2 Larval Trachea    1.85 Larval Carcass    4.55 Adult Head    20.3 Adult Eye    2.775 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    16.7 Adult Crop    3.8 Adult Midgut    35.6 Adult Hindgut    26.7 Adult Malpighian Tubules    160.9 Adult Fat Body no informative data Adult Salivary Gland    7.2 Adult Heart    3.875 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.7 Adult Testis    103.7 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.025 Larval Midgut    68.6 Larval Hindgut    23.1 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    5.2 Larval Trachea    1.85 Larval Carcass    4.55 Adult Head    20.3 Adult Eye    2.775 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    16.7 Adult Crop    3.8 Adult Midgut    35.6 Adult Hindgut    26.7 Adult Malpighian Tubules    160.9 Adult Fat Body no informative data Adult Salivary Gland    7.2 Adult Heart    3.875 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.7 Adult Testis    103.7 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.025 Larval Midgut    68.6 Larval Hindgut    23.1 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    5.2 Larval Trachea    1.85 Larval Carcass    4.55 Adult Head    20.3 Adult Eye    2.775 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    16.7 Adult Crop    3.8 Adult Midgut    35.6 Adult Hindgut    26.7 Adult Malpighian Tubules    160.9 Adult Fat Body no informative data Adult Salivary Gland    7.2 Adult Heart    3.875 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.7 Adult Testis    103.7 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.025 Larval Midgut    68.6 Larval Hindgut    23.1 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    5.2 Larval Trachea    1.85 Larval Carcass    4.55 Adult Head    20.3 Adult Eye    2.775 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    16.7 Adult Crop    3.8 Adult Midgut    35.6 Adult Hindgut    26.7 Adult Malpighian Tubules    160.9 Adult Fat Body no informative data Adult Salivary Gland    7.2 Adult Heart    3.875 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.7 Adult Testis    103.7 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032850 expression level Tissue   Expression Level Larval Central Nervous System    4.025 Larval Midgut    68.6 Larval Hindgut    23.1 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    5.2 Larval Trachea    1.85 Larval Carcass    4.55 Adult Head    20.3 Adult Eye    2.775 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    16.7 Adult Crop    3.8 Adult Midgut    35.6 Adult Hindgut    26.7 Adult Malpighian Tubules    160.9 Adult Fat Body no informative data Adult Salivary Gland    7.2 Adult Heart    3.875 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.7 Adult Testis    103.7 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.025 Larval Midgut    68.6 Larval Hindgut    23.1 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    5.2 Larval Trachea    1.85 Larval Carcass    4.55 Adult Head    20.3 Adult Eye    2.775 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    16.7 Adult Crop    3.8 Adult Midgut    35.6 Adult Hindgut    26.7 Adult Malpighian Tubules    160.9 Adult Fat Body no informative data Adult Salivary Gland    7.2 Adult Heart    3.875 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.7 Adult Testis    103.7 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.025 Larval Midgut    68.6 Larval Hindgut    23.1 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    5.2 Larval Trachea    1.85 Larval Carcass    4.55 Adult Head    20.3 Adult Eye    2.775 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    16.7 Adult Crop    3.8 Adult Midgut    35.6 Adult Hindgut    26.7 Adult Malpighian Tubules    160.9 Adult Fat Body no informative data Adult Salivary Gland    7.2 Adult Heart    3.875 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.7 Adult Testis    103.7 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.025 Larval Midgut    68.6 Larval Hindgut    23.1 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    5.2 Larval Trachea    1.85 Larval Carcass    4.55 Adult Head    20.3 Adult Eye    2.775 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    16.7 Adult Crop    3.8 Adult Midgut    35.6 Adult Hindgut    26.7 Adult Malpighian Tubules    160.9 Adult Fat Body no informative data Adult Salivary Gland    7.2 Adult Heart    3.875 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.7 Adult Testis    103.7 Adult Male Accessory Gland    6.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    20.3   NA  Eye    2.775   NA  Brain    8.8   4.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    16.7   NA  Crop    3.8   68.6  Midgut    35.6   23.1  Hindgut    26.7   no informative data  Malpighian Tubules    160.9   no informative data  Fat Body    no informative data   5.2  Salivary Gland    7.2   NA  Heart    3.875   1.85  Trachea    NA   NA  VirginFemale Spermatheca    5   NA  InseminatedFemale Spermatheca    5.3   NA  Ovary    2.7   NA  Testis    103.7   NA  Male Accessory Gland    6.1   4.55  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032850 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10723-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 KuaGD3661 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Kua Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Kua Class Mutagen Stocks Known lesion KuaGD3661 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes KuaKK108655 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3661} NA P{KK108655} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Kua allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0032850 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35300
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14450 Dere\GG21223 Dgri\GH13660 Dmoj\GI17412 Dper\GL26353 Dpse\GA10523 Dsec\GM17394 Dsim\GD24246 Dvir\GJ18345 Dwil\GK18676 Dyak\GE13298
Curated drosophilid orthologs	Dpse\GA10523
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001208-PA Aedes aegypti (mosquito) AGAP009703-PA Anopheles gambiae (mosquito) XP_396481.2 Apis mellifera (honey bee) At4g27030.1 Arabidopsis thaliana (wall cress) 260186 Branchiostoma floridae (lancelet) XP_001899832.1 Brugia malayi (roundworm nematode) BGIBMGA006224-PA Bombyx mori (silk worm) ENSBTAP00000013376 Bos taurus (bovine) CN17594 Caenorhabditis brenneri (small nematode) CBP31106 Caenorhabditis briggsae (nematode) CE22373 Caenorhabditis elegans (worm) ENSCAFP00000032303 Canis familiaris (dog) ENSCINP00000018140 Ciona intestinalis (sea squirt) JA09140 Caenorhabditis japonica (nematode) CPIJ005919 Culex pipens (mosquito) ENSCPOP00000014411 Cavia porcellus (guinea pig) 118667 Chlamidomonas reinhardtii (green alga) RP25135 Caenorhabditis remanei (nematode) ENSCSAVP00000004414 Ciona savignyi (sedentary tunicate) 120395 Capitella spl (polychaete worm) DDB0190504 Dictyostelium discoideum (amoeba) 218891 Daphnia pulex (daphnia) ENSDARP00000004945 Danio rerio (zebra fish) ENSECAP00000012971 Equus caballus (horse) ENSGACP00000015635 Gymnopilus aculeatus (mushroom) 111107 Hypsipyla robusta (cedar shoot borer) ENSP00000344166 Homo sapiens (human) ISCW002059-PA Ixodes scapularis (deer tick) 221531 Lottia gigantea (owl limpet) LmjF21.0440 Leishmania major (virus) ENSMMUP00000016037 Macaca mulatta (rhesus monkey) ENSMUSP00000006587 Mus musculus (house mouse) 103791 Nematostella vectensis (starlet anemone) 229327 Nematostella vectensis (starlet anemone) XP_001604133.1 Nasonia vitripennis (wasp) ENSOANP00000013826 Ornithorynchus anatinus (platypus) ENSORLP00000018871 Oryzias latipes (japanese killifish) LOC_Os08g08850.1 Oryza sativa (asian rice) 5033 Ostreococcus tauri (green alga) PP16410 Pristionchus pacificus (nematode) 25795 Physcomitrella patens (moss) ENSPPYP00000012429 Pongo pygmaeus (orangutan) 242721 Populus trichocarpa (black cottonwood) ENSPTRP00000052039 Pan troglodytes (chimpanzee) ENSRNOP00000051995 Rattus norvegicus (norway rat) 5044309 Sorghum bicolor (sorghum) XP_001182779.1 Strongylocentrotus purpuratus (purple sea urchin) 55713 Trichoplax adhaerens (metazoa) XP_975362.1 Tribolium castaneum (red flour beetle) Tc00.1047053511367.210 Trypanosoma cruzi (parasitic trypanosome) 17362 Thalassiosira pseudonana (marine diatom) ENSTRUP00000018469 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000051783 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11148 NV11394 LH20432 ISCW007247 ISCW002059 FBgn0230984 FBgn0220674 FBgn0205504 FBgn0195594 FBgn0172304 JGI_V11_218891 FBgn0070580 FBgn0163935 FBgn0140156 FBgn0121136 FBgn0113403 FBgn0091477 CPIJ005919 BGIBMGA006224 GB10104 AGAP009703 AAEL001208 GLEAN_13062
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v101360 P{KK108655}VIE-260B v30304 w1118; P{GD3661}v30304 v30305 w1118; P{GD3661}v30305
Genomic Clones ( 1 )
	BACR10H13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP01723
Other clones	FI14826
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	35247 EK011408 EP00607 IP01724
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032850 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35300
Antibody Information
Other Information
Discoverer
Etymology
	The designation "Kua" is after the Catalan word "cua", meaning "queue" or "tail". (Thomson et al., 2000)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Kua CG10723 (FlyBase, 1996-)
Additional comments	Source for merge of Kua CG10723 was Swiss-Prot update (date:001001). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136182 NM_001201927 RefSeq (Proteins) • NP_610026 NP_001188856 DDBJ / EMBL / GenBank • AAF00151 AAF53878 AC004364 ADV37105 AF152361 Entrez Gene - A searchable database of RefSeq genes. • 35300 UniProtKB/TrEMBL • Q9V3B5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Kua-ubiquitin conjugating enzyme hybrid, localisation (IPR019547)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0032850 DRSC - Results from RNAi screens. • FBgn0032850 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032850 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10723-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032850 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35300 InParanoid A subset of ortholog calls from InParanoid. • AAEL001208-PA Aedes aegypti (mosquito) AGAP009703-PA Anopheles gambiae (mosquito) XP_396481.2 Apis mellifera (honey bee) At4g27030.1 Arabidopsis thaliana (wall cress) 260186 Branchiostoma floridae (lancelet) XP_001899832.1 Brugia malayi (roundworm nematode) BGIBMGA006224-PA Bombyx mori (silk worm) ENSBTAP00000013376 Bos taurus (bovine) CN17594 Caenorhabditis brenneri (small nematode) CBP31106 Caenorhabditis briggsae (nematode) CE22373 Caenorhabditis elegans (worm) ENSCAFP00000032303 Canis familiaris (dog) ENSCINP00000018140 Ciona intestinalis (sea squirt) JA09140 Caenorhabditis japonica (nematode) CPIJ005919 Culex pipens (mosquito) ENSCPOP00000014411 Cavia porcellus (guinea pig) 118667 Chlamidomonas reinhardtii (green alga) RP25135 Caenorhabditis remanei (nematode) ENSCSAVP00000004414 Ciona savignyi (sedentary tunicate) 120395 Capitella spl (polychaete worm) DDB0190504 Dictyostelium discoideum (amoeba) 218891 Daphnia pulex (daphnia) ENSDARP00000004945 Danio rerio (zebra fish) ENSECAP00000012971 Equus caballus (horse) ENSGACP00000015635 Gymnopilus aculeatus (mushroom) 111107 Hypsipyla robusta (cedar shoot borer) ENSP00000344166 Homo sapiens (human) ISCW002059-PA Ixodes scapularis (deer tick) 221531 Lottia gigantea (owl limpet) LmjF21.0440 Leishmania major (virus) ENSMMUP00000016037 Macaca mulatta (rhesus monkey) ENSMUSP00000006587 Mus musculus (house mouse) 103791 Nematostella vectensis (starlet anemone) 229327 Nematostella vectensis (starlet anemone) XP_001604133.1 Nasonia vitripennis (wasp) ENSOANP00000013826 Ornithorynchus anatinus (platypus) ENSORLP00000018871 Oryzias latipes (japanese killifish) LOC_Os08g08850.1 Oryza sativa (asian rice) 5033 Ostreococcus tauri (green alga) PP16410 Pristionchus pacificus (nematode) 25795 Physcomitrella patens (moss) ENSPPYP00000012429 Pongo pygmaeus (orangutan) 242721 Populus trichocarpa (black cottonwood) ENSPTRP00000052039 Pan troglodytes (chimpanzee) ENSRNOP00000051995 Rattus norvegicus (norway rat) 5044309 Sorghum bicolor (sorghum) XP_001182779.1 Strongylocentrotus purpuratus (purple sea urchin) 55713 Trichoplax adhaerens (metazoa) XP_975362.1 Tribolium castaneum (red flour beetle) Tc00.1047053511367.210 Trypanosoma cruzi (parasitic trypanosome) 17362 Thalassiosira pseudonana (marine diatom) ENSTRUP00000018469 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000051783 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35300 modMine - Data generated by the modENCODE project. • FBgn0032850 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11148 NV11394 LH20432 ISCW007247 ISCW002059 FBgn0230984 FBgn0220674 FBgn0205504 FBgn0195594 FBgn0172304 JGI_V11_218891 FBgn0070580 FBgn0163935 FBgn0140156 FBgn0121136 FBgn0113403 FBgn0091477 CPIJ005919 BGIBMGA006224 GB10104 AGAP009703 AAEL001208 GLEAN_13062
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	38B.18 (McGill Drosophila Genome Project, 2001.9.25, Butler, 2001, Butler et al., 2001) CG10723 (Butler, 2001, Butler et al., 2001, Keleman et al., 2009.8.5) Kua
Name Synonym	Kua
Secondary FlyBase IDs
References ( 12 )
Research paper	Butler et al., 2001, Genetics 158(4): 1597--1614 Map position and expression of the genes in the 38 region of Drosophila. [FBrf0138405] Thomson et al., 2000, Genome Res. 10(11): 1743--1756 Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. [FBrf0137432]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Butler, 2001, Genetics 158(4): Supplemental Material 3. Gene predictions and transcripts of the cytological region 38. [FBrf0139854]
Review	Long, 2000, Genome Res. 10(11): 1655--1657 A new function evolved from gene fusion. [FBrf0134869]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] McGill Drosophila Genome Project, 2001.9.25, FASTA sequences of Gene Predictions of the 38 region. FASTA sequences of Gene Predictions of the 38 region. [FBrf0139855]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
DNA/RNA sequence record	Thomson, 1999.5.18, GenBank/EMBL/DDBJ: AF152361 Drosophila melanogaster Kua protein mRNA, partial cds. [FBrf0132019]