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Gene Dmel\Mio

General Information
Symbol	Dmel\Mio	Species	D. melanogaster
Name	Mlx interactor	Annotation symbol	CG18362
Feature type	protein_coding_gene	FlyBase ID	FBgn0032940
Gene Model Status	Current	Stock availability	13 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	39C1-39C2	Sequence location	2L:21,286,078..21,310,050 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Mlx interactor is referred to in FlyBase by the symbol Dmel\Mio (CG18362, FBgn0032940). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process: regulation of transcription, DNA-dependent. 19 alleles are reported. No phenotypic data is available. It has 11 annotated transcripts and 11 annotated polypeptides. Protein features are: Myc-type, basic helix-loop-helix (bHLH) domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules, larval/adult fat body, adult spermathecae, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult salivary gland, larval trachea, adult ovary, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628873_s_at completely aligns to an exonic region common to each of the 13 FlyBase-annotated transcript isoforms of Mio. Gene sequence location is 2L:21286078..21310050.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 39C1-39C2   Limits computationally determined from genome sequence between P{lacW}l(2)k14505k14505&P{lacW}l(2)k05106k05106 and P{PZ}l(2)05095a05095a
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mio for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mio-RA FBtr0081525  NM_165367   3837   1119 Mio-RB FBtr0081524  NM_136261   4276   1119 Mio-RE FBtr0081527  NM_165368   3300   925 Mio-RF FBtr0301457  NM_001169561   4834   1119 Mio-RG FBtr0301458  NM_001169562   3928   1119 Mio-RH FBtr0301459  NM_001169563   4837   1119 Mio-RI FBtr0301460  NM_001169564   4349   1119 Mio-RJ FBtr0301461  NM_001169565   4276   1119 Mio-RK FBtr0301462  NM_001169566   3830   1119 Mio-RL FBtr0301463  NM_001169567   3832   1119 Mio-RM FBtr0301464  NM_001169568   4068   1119
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mio-PA   FBpp0081053   125.2   1119   7.60     NP_724326   AAF53988 Mio-PB   FBpp0081052   125.2   1119   7.60     NP_610105   AAF53989 Mio-PE   FBpp0081055   103.0   925   8.64     NP_724327   AAN11112 Mio-PF   FBpp0290672   125.2   1119   7.60     NP_001163032   ACZ94318 Mio-PG   FBpp0290673   125.2   1119   7.60     NP_001163033   ACZ94319 Mio-PH   FBpp0290674   125.2   1119   7.60     NP_001163034   ACZ94320 Mio-PI   FBpp0290675   125.2   1119   7.60     NP_001163035   ACZ94321 Mio-PJ   FBpp0290676   125.2   1119   7.60     NP_001163036   ACZ94322 Mio-PK   FBpp0290677   125.2   1119   7.60     NP_001163037   ACZ94323 Mio-PL   FBpp0290678   125.2   1119   7.60     NP_001163038   ACZ94324 Mio-PM   FBpp0290679   125.2   1119   7.60     NP_001163039   ACZ94325
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Myc-type, basic helix-loop-helix (bHLH) domain (IPR011598)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA438672   AA439882   AA536583   AA539723   AA817663   AA941123   AA941707   AA948883   AA949050   AA949955   AA951393   AA952134   AE014134 AAF53988   AE014134 AAF53989   AE014134 AAN11112   AE014134 ACZ94318   AE014134 ACZ94319   AE014134 ACZ94320   AE014134 ACZ94321   AE014134 ACZ94322   AE014134 ACZ94323   AE014134 ACZ94324   AE014134 ACZ94325   AF264754 AAK20946   AF264755 AAK20947   AF264756 AAK20948   AI061902   AI107777   AI386736   AI405319   AI455433   AI456382   AI518638   AI519124   AI531757   AW943416   AY051894 AAK93318   BF494955   BG638493   BG638509   BG639588   BH615126   BI163805   BI229557   BI229964   BI232331   BI238538   BI238884   BI358609   BI361992   BI364009   BI369414   BI370152   BI374242   BI638101   BP558647   BT099679   BT133442   CK657007   CK661039   CL705865   CO187685   CO188744   CO263570   CO268403   CO275943   CO279414   CO280335   CO283664   CO290122   CO291294   CO296150   CO300311   CO306231   CO314755   CO316325   CO317720   CO323132   CO329918   CO330625   CO331137   CZ476875   CZ476909   CZ477346   CZ477347   EC057642   EC057767   EC061820   EC062445   EC066650   EC070523   EC071079   EC072762   EC076837   EC077438   EC077944   EC080642   EC082988   EC087172   EC088587   EC090254   EC090277   EC091034   EC091035   EC091036   EC194974   EC195130   EC196350   EC202873   EC203985   EC206086   EC209867   EC219359   EC220352   EC227909   EC233203   EC235777   EC250123   EV577443   EV585678
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8INT6 Q9VID4 Q9BKE5 Q9BKE4 Q8INT7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   amnioserosa   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 10 -- 15   amnioserosa   (Peyrefitte et al., 2001) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 13 -- 15   dorsal pharyngeal muscle primordium   (Peyrefitte et al., 2001) embryonic stage 13 -- 16   amnioserosa   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 16   embryonic/larval fat body   (Peyrefitte et al., 2001)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules, larval/adult fat body, adult spermathecae, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult salivary gland, larval trachea, adult ovary, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    205.375 Larval Midgut    402.7 Larval Hindgut    144.6 Larval Malpighian Tubules    628.3 Larval Fat Body    546.2 Larval Salivary Gland    298.2 Larval Trachea    215.15 Larval Carcass    159.175 Adult Head    247 Adult Eye    258.625 Adult Brain    266.8 Adult Thoracic-Abdominal Ganglion    242.3 Adult Crop    254.7 Adult Midgut    209.9 Adult Hindgut    196.3 Adult Malpighian Tubules    1592.9 Adult Fat Body    786.5 Adult Salivary Gland    343.2 Adult Heart    473.8 Adult VirginFemale Spermatheca    861 Adult InseminatedFemale Spermatheca    666.8 Adult Ovary    350.7 Adult Testis    98.1 Adult Male Accessory Gland    539.7 Adult Carcass    475.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    205.375 Larval Midgut    402.7 Larval Hindgut    144.6 Larval Malpighian Tubules  (628.3) Larval Fat Body  (546.2) Larval Salivary Gland    298.2 Larval Trachea    215.15 Larval Carcass    159.175 Adult Head    247 Adult Eye    258.625 Adult Brain    266.8 Adult Thoracic-Abdominal Ganglion    242.3 Adult Crop    254.7 Adult Midgut    209.9 Adult Hindgut    196.3 Adult Malpighian Tubules  (1592.9) Adult Fat Body  (786.5) Adult Salivary Gland    343.2 Adult Heart    473.8 Adult VirginFemale Spermatheca  (861) Adult InseminatedFemale Spermatheca  (666.8) Adult Ovary    350.7 Adult Testis    98.1 Adult Male Accessory Gland  (539.7) Adult Carcass    475.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    205.375 Larval Midgut    402.7 Larval Hindgut    144.6 Larval Malpighian Tubules    628.3 Larval Fat Body    546.2 Larval Salivary Gland    298.2 Larval Trachea    215.15 Larval Carcass    159.175 Adult Head    247 Adult Eye    258.625 Adult Brain    266.8 Adult Thoracic-Abdominal Ganglion    242.3 Adult Crop    254.7 Adult Midgut    209.9 Adult Hindgut    196.3 Adult Malpighian Tubules  (1592.9) Adult Fat Body    786.5 Adult Salivary Gland    343.2 Adult Heart    473.8 Adult VirginFemale Spermatheca    861 Adult InseminatedFemale Spermatheca    666.8 Adult Ovary    350.7 Adult Testis    98.1 Adult Male Accessory Gland    539.7 Adult Carcass    475.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    205.375 Larval Midgut    402.7 Larval Hindgut    144.6 Larval Malpighian Tubules    628.3 Larval Fat Body    546.2 Larval Salivary Gland    298.2 Larval Trachea    215.15 Larval Carcass    159.175 Adult Head    247 Adult Eye    258.625 Adult Brain    266.8 Adult Thoracic-Abdominal Ganglion    242.3 Adult Crop    254.7 Adult Midgut    209.9 Adult Hindgut    196.3 Adult Malpighian Tubules    1592.9 Adult Fat Body    786.5 Adult Salivary Gland    343.2 Adult Heart    473.8 Adult VirginFemale Spermatheca    861 Adult InseminatedFemale Spermatheca    666.8 Adult Ovary    350.7 Adult Testis    98.1 Adult Male Accessory Gland    539.7 Adult Carcass    475.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    205.375 Larval Midgut    402.7 Larval Hindgut    144.6 Larval Malpighian Tubules    628.3 Larval Fat Body    546.2 Larval Salivary Gland    298.2 Larval Trachea    215.15 Larval Carcass    159.175 Adult Head    247 Adult Eye    258.625 Adult Brain    266.8 Adult Thoracic-Abdominal Ganglion    242.3 Adult Crop    254.7 Adult Midgut    209.9 Adult Hindgut    196.3 Adult Malpighian Tubules    1592.9 Adult Fat Body    786.5 Adult Salivary Gland    343.2 Adult Heart    473.8 Adult VirginFemale Spermatheca    861 Adult InseminatedFemale Spermatheca    666.8 Adult Ovary    350.7 Adult Testis    98.1 Adult Male Accessory Gland    539.7 Adult Carcass    475.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    205.375 Larval Midgut    402.7 Larval Hindgut    144.6 Larval Malpighian Tubules  628.3 Larval Fat Body  546.2 Larval Salivary Gland    298.2 Larval Trachea    215.15 Larval Carcass    159.175 Adult Head    247 Adult Eye    258.625 Adult Brain    266.8 Adult Thoracic-Abdominal Ganglion    242.3 Adult Crop    254.7 Adult Midgut    209.9 Adult Hindgut    196.3 Adult Malpighian Tubules  (1592.9) Adult Fat Body  786.5 Adult Salivary Gland    343.2 Adult Heart    473.8 Adult VirginFemale Spermatheca  (861) Adult InseminatedFemale Spermatheca  666.8 Adult Ovary    350.7 Adult Testis    98.1 Adult Male Accessory Gland  539.7 Adult Carcass    475.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    205.375 Larval Midgut    402.7 Larval Hindgut    144.6 Larval Malpighian Tubules    628.3 Larval Fat Body    546.2 Larval Salivary Gland    298.2 Larval Trachea    215.15 Larval Carcass    159.175 Adult Head    247 Adult Eye    258.625 Adult Brain    266.8 Adult Thoracic-Abdominal Ganglion    242.3 Adult Crop    254.7 Adult Midgut    209.9 Adult Hindgut    196.3 Adult Malpighian Tubules  1592.9 Adult Fat Body    786.5 Adult Salivary Gland    343.2 Adult Heart    473.8 Adult VirginFemale Spermatheca    861 Adult InseminatedFemale Spermatheca    666.8 Adult Ovary    350.7 Adult Testis    98.1 Adult Male Accessory Gland    539.7 Adult Carcass    475.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    205.375 Larval Midgut    402.7 Larval Hindgut    144.6 Larval Malpighian Tubules    628.3 Larval Fat Body    546.2 Larval Salivary Gland    298.2 Larval Trachea    215.15 Larval Carcass    159.175 Adult Head    247 Adult Eye    258.625 Adult Brain    266.8 Adult Thoracic-Abdominal Ganglion    242.3 Adult Crop    254.7 Adult Midgut    209.9 Adult Hindgut    196.3 Adult Malpighian Tubules    1592.9 Adult Fat Body    786.5 Adult Salivary Gland    343.2 Adult Heart    473.8 Adult VirginFemale Spermatheca    861 Adult InseminatedFemale Spermatheca    666.8 Adult Ovary    350.7 Adult Testis    98.1 Adult Male Accessory Gland    539.7 Adult Carcass    475.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    247   NA  Eye    258.625   NA  Brain    266.8   205.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    242.3   NA  Crop    254.7   402.7  Midgut    209.9   144.6  Hindgut    196.3   628.3  Malpighian Tubules    1592.9   546.2  Fat Body    786.5   298.2  Salivary Gland    343.2   NA  Heart    473.8   215.15  Trachea    NA   NA  VirginFemale Spermatheca    861   NA  InseminatedFemale Spermatheca    666.8   NA  Ovary    350.7   NA  Testis    98.1   NA  Male Accessory Gland    539.7   159.175  Carcass    475.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    9 central nervous system, pupae P8    8 head, virgin 1-day female    18 head, virgin 4-day female    12 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    14 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    8 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    16 ovary, virgin 4-day female    30 ovary, mated 4-day female    29 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    9 central nervous system, pupae P8    8 head, virgin 1-day female    18 head, virgin 4-day female    12 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    14 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    8 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    16 ovary, virgin 4-day female  (30) ovary, mated 4-day female  (29) testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    9 central nervous system, pupae P8    8 head, virgin 1-day female    18 head, virgin 4-day female    12 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    14 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    8 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    16 ovary, virgin 4-day female    30 ovary, mated 4-day female    29 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    9 central nervous system, pupae P8    8 head, virgin 1-day female    18 head, virgin 4-day female    12 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    14 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    8 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    16 ovary, virgin 4-day female    30 ovary, mated 4-day female    29 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    9 central nervous system, pupae P8    8 head, virgin 1-day female    18 head, virgin 4-day female    12 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    14 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    8 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    16 ovary, virgin 4-day female    30 ovary, mated 4-day female    29 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    9 central nervous system, pupae P8    8 head, virgin 1-day female    18 head, virgin 4-day female    12 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    14 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    8 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    16 ovary, virgin 4-day female  30 ovary, mated 4-day female  29 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    9 central nervous system, pupae P8    8 head, virgin 1-day female    18 head, virgin 4-day female    12 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    14 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    8 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    16 ovary, virgin 4-day female    30 ovary, mated 4-day female    29 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    9 central nervous system, pupae P8    8 head, virgin 1-day female    18 head, virgin 4-day female    12 head, virgin 20-day female    17 head, mated 1-day female    17 head, mated 4-day female    12 head, mated 20-day female    14 head, mated 1-day male    15 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    14 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    8 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    16 ovary, virgin 4-day female    30 ovary, mated 4-day female    29 testis, mated 4-day male    3 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    47 embryo 04-06hr    48 embryo 06-08hr    56 embryo 08-10hr    48 embryo 10-12hr    33 embryo 12-14hr    50 embryo 14-16hr    48 embryo 16-18hr    73 embryo 18-20hr    100 embryo 20-22hr    102 embryo 22-24hr    131 larva L1    42 larva L2    32 larva L3 12hr old    24 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    18 white prepupae new    20 white prepupae 12hr    23 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    17 adult male 01day    19 adult male 05day    20 adult male 30day    21 adult female 01day    31 adult female 05day    40 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (47) embryo 04-06hr  (48) embryo 06-08hr  (56) embryo 08-10hr  (48) embryo 10-12hr  (33) embryo 12-14hr  (50) embryo 14-16hr  (48) embryo 16-18hr  (73) embryo 18-20hr  (100) embryo 20-22hr  (102) embryo 22-24hr  (131) larva L1  (42) larva L2  (32) larva L3 12hr old    24 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    18 white prepupae new    20 white prepupae 12hr    23 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    17 adult male 01day    19 adult male 05day    20 adult male 30day    21 adult female 01day  (31) adult female 05day  (40) adult female 30day  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    47 embryo 04-06hr    48 embryo 06-08hr    56 embryo 08-10hr    48 embryo 10-12hr    33 embryo 12-14hr    50 embryo 14-16hr    48 embryo 16-18hr    73 embryo 18-20hr    100 embryo 20-22hr  102 embryo 22-24hr  (131) larva L1    42 larva L2    32 larva L3 12hr old    24 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    18 white prepupae new    20 white prepupae 12hr    23 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    17 adult male 01day    19 adult male 05day    20 adult male 30day    21 adult female 01day    31 adult female 05day    40 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    47 embryo 04-06hr    48 embryo 06-08hr    56 embryo 08-10hr    48 embryo 10-12hr    33 embryo 12-14hr    50 embryo 14-16hr    48 embryo 16-18hr    73 embryo 18-20hr    100 embryo 20-22hr    102 embryo 22-24hr    131 larva L1    42 larva L2    32 larva L3 12hr old    24 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    18 white prepupae new    20 white prepupae 12hr    23 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    17 adult male 01day    19 adult male 05day    20 adult male 30day    21 adult female 01day    31 adult female 05day    40 adult female 30day    40 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    47 embryo 04-06hr    48 embryo 06-08hr    56 embryo 08-10hr    48 embryo 10-12hr    33 embryo 12-14hr    50 embryo 14-16hr    48 embryo 16-18hr    73 embryo 18-20hr    100 embryo 20-22hr    102 embryo 22-24hr    131 larva L1    42 larva L2    32 larva L3 12hr old    24 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    18 white prepupae new    20 white prepupae 12hr    23 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    17 adult male 01day    19 adult male 05day    20 adult male 30day    21 adult female 01day    31 adult female 05day    40 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (47) embryo 04-06hr  (48) embryo 06-08hr  (56) embryo 08-10hr  (48) embryo 10-12hr  (33) embryo 12-14hr  (50) embryo 14-16hr  (48) embryo 16-18hr  (73) embryo 18-20hr  (100) embryo 20-22hr  (102) embryo 22-24hr  (131) larva L1  (42) larva L2  32 larva L3 12hr old    24 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    18 white prepupae new    20 white prepupae 12hr    23 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    17 adult male 01day    19 adult male 05day    20 adult male 30day    21 adult female 01day  31 adult female 05day  (40) adult female 30day  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    47 embryo 04-06hr    48 embryo 06-08hr    56 embryo 08-10hr    48 embryo 10-12hr    33 embryo 12-14hr    50 embryo 14-16hr    48 embryo 16-18hr    73 embryo 18-20hr    100 embryo 20-22hr  102 embryo 22-24hr  131 larva L1    42 larva L2    32 larva L3 12hr old    24 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    18 white prepupae new    20 white prepupae 12hr    23 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    17 adult male 01day    19 adult male 05day    20 adult male 30day    21 adult female 01day    31 adult female 05day    40 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    47 embryo 04-06hr    48 embryo 06-08hr    56 embryo 08-10hr    48 embryo 10-12hr    33 embryo 12-14hr    50 embryo 14-16hr    48 embryo 16-18hr    73 embryo 18-20hr    100 embryo 20-22hr    102 embryo 22-24hr    131 larva L1    42 larva L2    32 larva L3 12hr old    24 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    18 white prepupae new    20 white prepupae 12hr    23 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    13 pupae 4d postWPP    17 adult male 01day    19 adult male 05day    20 adult male 30day    21 adult female 01day    31 adult female 05day    40 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    8 embryonic 1182-4H    15 embryonic GM2    24 embryonic Kc167    12 embryonic S1    16 embryonic S3    9 leg disc CME L1    8 wing disc CME-W2    15 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    19 ovary fGS/OSS    20 ovary OSC    12 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    8 embryonic 1182-4H    15 embryonic GM2    24 embryonic Kc167    12 embryonic S1    16 embryonic S3    9 leg disc CME L1    8 wing disc CME-W2    15 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2  26 tumorous blood cells mbn2    19 ovary fGS/OSS    20 ovary OSC    12 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    8 embryonic 1182-4H    15 embryonic GM2    24 embryonic Kc167    12 embryonic S1    16 embryonic S3    9 leg disc CME L1    8 wing disc CME-W2    15 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    19 ovary fGS/OSS    20 ovary OSC    12 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    8 embryonic 1182-4H    15 embryonic GM2    24 embryonic Kc167    12 embryonic S1    16 embryonic S3    9 leg disc CME L1    8 wing disc CME-W2    15 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    19 ovary fGS/OSS    20 ovary OSC    12 ovary OSS    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    8 embryonic 1182-4H    15 embryonic GM2    24 embryonic Kc167    12 embryonic S1    16 embryonic S3    9 leg disc CME L1    8 wing disc CME-W2    15 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    19 ovary fGS/OSS    20 ovary OSC    12 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    8 embryonic 1182-4H    15 embryonic GM2    24 embryonic Kc167    12 embryonic S1    16 embryonic S3    9 leg disc CME L1    8 wing disc CME-W2    15 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2  26 tumorous blood cells mbn2    19 ovary fGS/OSS    20 ovary OSC    12 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    8 embryonic 1182-4H    15 embryonic GM2    24 embryonic Kc167    12 embryonic S1    16 embryonic S3    9 leg disc CME L1    8 wing disc CME-W2    15 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    19 ovary fGS/OSS    20 ovary OSC    12 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    8 embryonic 1182-4H    15 embryonic GM2    24 embryonic Kc167    12 embryonic S1    16 embryonic S3    9 leg disc CME L1    8 wing disc CME-W2    15 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    19 ovary fGS/OSS    20 ovary OSC    12 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_09 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD38259 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032940 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18362-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Mio Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive MioYD1036 viable MioEY00908 Sterility Allele fertile MioEY00908 Other Phenotypes Allele feeding behavior defective | adult stage, with Scer\GAL4yolk MiodsRNA.Sym.Scer\UAS Phenotype manifest in Allele
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of Mio Class Mutagen Stocks Known lesion Miok05106 2 -- MioCB-6419-3 1 -- Miod09672 P-element activity 1 -- MioEY00908 P-element activity 1 -- Miof00925 1 -- MioKG04302 P-element activity 1 -- MioMI02153 1 -- MioNP1568 1 -- MioCPTI003395 piggyBac transposase 0 Yes Miod09728 P-element activity 0 -- Miod10611 P-element activity 0 -- MioNP4218 0 -- MioYD1036 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mio Class Mutagen Stocks Known lesion MioGD12723 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes MioJF02400 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MioT:Avic\GFP-SF,T:Zzzz\FLAG,T:Zzzz\PSP.CS,T:Zzzz\TEV.CS,T:Zzzz\BLRP in vitro construct - coding region fusion 1 Yes MiodsRNA.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes MioKK109174 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes MioNIG.18362R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Rev4 (Hewes et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12723} NA P{KK109174} NA P{NIG.18362R} NA P{TRiP.JF02400} NA P{UAS-Mio.dsRNA.Sym} NA characterization construct PBac{Mio-GFP.FPTB} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Gr39ak05106 No P{lacW}l(2)SH2227SH2227 No insertion of mobile activating element P{EPgy2}MioEY00908 NA P{XP}Miod09672 NA P{XP}Miod09728 NA P{XP}Miod10611 NA miscellaneous insertions Mi{MIC}MioMI02153 NA P{RS3}MioCB-6419-3 NA P{SUPor-P}MioKG04302 NA PBac{768.FSVS-0}MioCPTI003395 NA PBac{HpaI-GFP.A}MioYD1036 NA PBac{WH}Miof00925 NA insertion of enhancer trap binary system P{GawB}MioNP1568 No P{GawB}MioNP4218 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
protein dimerization activity inferred from electronic annotation with InterPro:IPR011598 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with EMBL:AF056184 (FlyBase, 1992-) non-traceable author statement (Cairo, 2000.5.9)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with Max (Peyrefitte et al., 2001)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with EMBL:AF056184 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
RNA-protein
Interacting group Assay References
Mio - B52 systematic evolution of ligands by exponential enrichment, full identification by DNA sequencing, electrophoretic mobility shift assay, autoradiography (Kim et al., 2003)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mio allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61352 DroID - A comprehensive database of gene and protein interactions. • FBgn0032940 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35402
Orthologs
OrthoDB Orthologs (51) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6CC4KT Dipteran inclusive ortholog search EOG676K7B Insect inclusive ortholog search EOG6CZ99W Arthropod inclusive ortholog search EOG6QFTV8 Metazoa inclusive ortholog search EOG66QKN5
Orthologs in Drosophila Species (EOG6CC4KT)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Mio     Drosophila simulans   Dsim\GD21641 Y   Drosophila sechellia   Dsec\GM23262 Y   Drosophila erecta   Dere\GG21509 Y   Drosophila yakuba   Dyak\GE12990 Y   Drosophila ananassae   Dana\GF15566 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14905 Y   Drosophila persimilis   Dper\GL26357 Y   Drosophila willistoni   Dwil\GK18680 Y   Drosophila virilis   Dvir\GJ18379 Y   Drosophila mojavensis   Dmoj\GI17432 Y   Drosophila grimshawi   Dgri\GH13021 Y
Orthologs in non-Drosophila Dipterans (EOG676K7B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007271   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013944   Anopheles gambiae Malaria mosquito  Agam\AGAP009806   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008846
Orthologs in non-Dipteran Insects (EOG6CZ99W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Mio   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002493   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14948   Atta cephalotes Leafcutter ant  Acep\ACEP17922   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23170   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14507   Linepithema humile Argentine ant  Lhum\LH19566   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17894   Solenopsis invicta Red fire ant  Sinv\SINV18500   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008807   Bombyx mori Silkmoth  Bmor\BGIBMGA006808   Pediculus humanus Human body louse  Phum\PHUM369750   Tribolium castaneum Red flour beetle  Tcas\TC010471
Orthologs in non-Insect Arthropods (EOG6QFTV8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\BEX4   Daphnia pulex Water flea  Dpux\IRGC
Orthologs in non-Arthropod Metazoa (EOG66QKN5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mml-1 Y Caenorhabditis elegans Nematode  Cele\mxl-2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008845gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005787gn Y Danio rerio Zebrafish  Drer\mlxip Y Danio rerio Zebrafish  Drer\si:ch1073-189o9.1 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030310 Y Xenopus tropicalis Western clawed frog  Xtro\mlx Y Xenopus tropicalis Western clawed frog  Xtro\mlxip Y Gallus gallus Domestic chicken  Ggal\MLX Y Gallus gallus Domestic chicken  Ggal\MLXIPL Y Gallus gallus Domestic chicken  Ggal\MLXIP Y Mus musculus House mouse  Mmus\Mlx Y Mus musculus House mouse  Mmus\Mlxipl Y Mus musculus House mouse  Mmus\Mlxip Y Rattus norvegicus Norway rat  Rnor\Mlx Y Rattus norvegicus Norway rat  Rnor\Mlxip Y Homo sapiens Human  Hsap\MLXIP Y Homo sapiens Human  Hsap\ENSG00000009950 Y Homo sapiens Human  Hsap\MLX Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\MLXIP     Hsap\ENSG00000009950     Hsap\MLX
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21641 Drosophila sechellia Dsec\GM23262 Drosophila erecta Dere\GG21509 Drosophila yakuba Dyak\GE12990 Drosophila ananassae Dana\GF15566 Drosophila pseudoobscura pseudoobscura Dpse\GA14905 Drosophila persimilis Dper\GL26357 Drosophila willistoni Dwil\GK18680 Drosophila virilis Dvir\GJ18379 Drosophila mojavensis Dmoj\GI17432 Drosophila grimshawi Dgri\GH13021
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	42279 w1118; PBac{Mio-GFP.FPTB}VK00033 27059 y1 v1; P{TRiP.JF02400}attP2 20102 y1 w67c23; P{EPgy2}MioEY00908 34282 y1 w*; Mi{MIC}MioMI02153/SM6a 13366 y1 w67c23; P{SUPor-P}MioKG04302 10562 y1 w67c23; P{lacW}Gr39ak05106/CyO
Harvard	- P{XP}Miod09672 - PBac{WH}Miof00925
Kyoto	124095 w1118; P{RS3}MioCB-6419-3 102338 y1 w67c23 ; P{lacW}Gr39ak05106 / CyO
VDRC	v52606 w1118 P{GD12723}v52606 v52607 w1118 P{GD12723}v52607
	More stocks available...
Genomic Clones ( 1 )
	BACR34H23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 88 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD38259 RE22394
Other clones	FI20159
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03745 GH05627 GH16922 GH25281 LD12993 LD14563 LD17345 LD18031 LD25090 LD27558 LD28533 LD29207 LD31826 LD34966 LD36386 LD38551 LP20124 LP22919 RE03314 RE27363 RE27869 RE28380 RE35027 RE41989 RE45438 RE46440 RE49029 RE55589 RE56566 RE61784 SD20308
Other clones	20259 31328 39870 53806 74451 80476 109271 117960 147180 160826 160842 164018 167264 191280 191602 192651 CK01.10A.C8 CK01.28C.H6 CK01.35C.H3 CK01.36D.E4 CK01.50D.C6 CK01.93D.E3 CK01.100B.E10 CK01.113A.D10 CK01.119D.D10 CK01.145A.C5 CK01.168C.E3 Dmel_dig_012012_0671_2257 Dmel_dig_017673_0653_1300 EK031350 EK041743 EK073118 EK077349 EK088938 EK091247 EK119211 EK134254 EK153813 EK164029 EK177920 EK189805 EK212852 EK237722 EK250558 EK264528 EK268854 EK294148 EK295752 EK298534 FGM316C06 LD24192 LD27073 LD27794 SD03013
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032940 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35402
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mio CG18362 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Mio CG18362 was sequence identity (date:011221). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136261 NM_165367 NM_165368 NM_001169561 NM_001169562 NM_001169563 NM_001169564 NM_001169565 NM_001169566 NM_001169567 NM_001169568 RefSeq (Proteins) • NP_610105 NP_724326 NP_724327 NP_001163032 NP_001163033 NP_001163034 NP_001163035 NP_001163036 NP_001163037 NP_001163038 NP_001163039 DDBJ / EMBL / GenBank • AAF53988 AAF53989 AAK20946 AAK20947 AAK20948 AAK93318 AAN11111 AAN11112 AAN11113 ACZ94318 ACZ94319 ACZ94320 ACZ94321 ACZ94322 ACZ94323 ACZ94324 ACZ94325 AF264754 AF264755 AF264756 AI518638 AW943416 AY051894 BH615126 CL705865 CZ476875 CZ476909 CZ477346 CZ477347 Entrez Gene - A searchable database of RefSeq genes. • 35402 UniProtKB/TrEMBL • Q8INT6 Q8INT7 Q9BKE4 Q9BKE5 Q9VID4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Myc-type, basic helix-loop-helix (bHLH) domain (IPR011598) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD38259
Linkouts
	BioGRID - A database of protein and genetic interactions • 61352 DroID - A comprehensive database of gene and protein interactions. • FBgn0032940 DRSC - Results from RNAi screens. • FBgn0032940 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032940 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18362-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032940 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35402 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35402 modMine - Data generated by the modENCODE project. • FBgn0032940
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	154826_at (Kristensen et al., 2005) anon-39Da   bHLHd12 (Stevens et al., 2008) CG18362 (Hewes et al., 2003, Peyrefitte et al., 2001, Ledent and Vervoort, 2001, Quinones-Coello, 2007, Quinones-Coello, 2007, Stevens et al., 2008, Stevens et al., 2008, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5) dmondo (Billin et al., 2000) Mio (Quinones-Coello, 2007, Quinones-Coello, 2007, Sassu et al., 2012, Alic et al., 2011, Ren et al., 2011, Cairo et al., 2001, Japanese National Institute of Genetics, 2012.5.21) Mondo (McFerrin and Atchley, 2012) unnamed (Clyne et al., 2000)
Name Synonym	Mlx interactor   WBSCR14-related (Cairo et al., 2001)
Secondary FlyBase IDs
	FBgn0041170
References ( 41 )
Generate a list of	All references relating to this gene ( 41 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 11 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Musselman et al., 2013, J. Biol. Chem. 288(12): 8028--8042 Role of Fat Body Lipogenesis in Protection against the Effects of Caloric Overload in Drosophila. [FBrf0221124] McFerrin and Atchley, 2012, PLoS ONE 7(4): e34803 A novel N-terminal domain may dictate the glucose response of Mondo proteins. [FBrf0219762] Sassu et al., 2012, Biochem. Biophys. Res. Commun. 426(1): 43--48 Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila. [FBrf0219467] Alic et al., 2011, Mol. Syst. Biol. 7: 502 Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. [FBrf0214014] Ren et al., 2011, Hum. Mol. Genet. 20(17): 3424--3436 A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome. [FBrf0214639] Show all research papers ...