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Gene Dmel\Cul-2

General Information
Symbol	Dmel\Cul-2	Species	D. melanogaster
Name	Cullin-2	Annotation symbol	CG1512
Feature type	protein_coding_gene	FlyBase ID	FBgn0032956
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	CUL2, l(2)02074
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	39E3-39E6	Sequence location	2L:21,658,752..21,663,218 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cullin-2 is referred to in FlyBase by the symbol Dmel\Cul-2 (CG1512, FBgn0032956). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: ubiquitin protein ligase binding. There is experimental evidence that it is involved in the biological process: growth of a germarium-derived egg chamber; regulation of synaptic growth at neuromuscular junction; neurogenesis. 9 alleles are reported. The phenotypes of these alleles are annotated with: interfollicle cell; terminal filament; oocyte; mesothoracic tergum; egg chamber; germarium; nurse cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cullin homology; Cullin protein, neddylation domain; Cullin repeat-like-containing domain; Cullin, N-terminal; Cullin, conserved site; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637515_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Cul-2. Gene sequence location is 2L:21658752..21663218.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Controlled Vocabulary Terms regulation of synaptic growth at neuromuscular junction growth of a germarium-derived egg chamber References Makunin and Yurlova, 2010, Genetika, Moscow 46(9): 1202--1204 Ayyub, 2011, J. Genet. 90(2): 239--249 Sequence features HFA03710 BKN20636
FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Controlled Vocabulary Terms day 6 of adulthood day 5 of adulthood male day 7 of adulthood spermatozoon
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 39E3-39E6   Limits computationally determined from genome sequence between P{lacW}Df31k05815 and P{PZ}cul-202074&P{lacW}l(2)k08110k08110
Experimentally Determined Cytological Location
Cytogenetic map Notes References 39F1-39F2   (determined by in situ hybridisation)   (Spradling et al., 1999) 39E5-39E7   39F1--2   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cul-2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cul-2-RA FBtr0085899  NM_165390   2929   753 Cul-2-RB FBtr0085900  NM_136273   2822   753
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cul-2-PA   FBpp0085254   87.4   753   6.91     NP_724352   AAF57224 Cul-2-PB   FBpp0085255   87.4   753   6.91     NP_610117   AAG22124
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cullin, N-terminal (IPR001373) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991) Cullin, conserved site (IPR016157) Cullin homology (IPR016158) Cullin repeat-like-containing domain (IPR016159) Cullin protein, neddylation domain (IPR019559)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696646   AE014134 AAF57224   AE014134 AAG22124   AI456285   AI517046   AI518728   AI533723   AW943328   AY061434 AAL28982   BE977057   BG635496   BG638871   BG639762   BI165869   BI169118   BI234665   BI236830   BI236895   BI487148   BI640633   BP549119   CK661189   CL705836   CO179118   CO185574   CO186577   CO187379   CO270496   CO276630   CO283728   CO284928   CO285231   CO290314   CO290471   CO292431   CO294894   CO297691   CO302013   CO304400   CO307441   CO326199   CO326846   CO331046   CO339655   CO342975   CO343954   EC070125   EC071675   EC075090   EC080330   EC085012   EC085301   EC195900   EC197001   EC203632   EC205056   EC207810   EC208412   EC217299   EC219213   EC229263   EC229264   EC246019   EC247477   EC253142   EC253658   EC254334   EC254374   EC257422   EC261395   EL886410   EL886633   EL886743   G00597
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V9R2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032956    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032956 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032956 expression level Developmental Stage   Expression Level embryo 00-02hr    3714 embryo 02-04hr    2903 embryo 04-06hr    3611 embryo 06-08hr    3187 embryo 08-10hr    3415 embryo 10-12hr    2350 embryo 12-14hr    2775 embryo 14-16hr    1175 embryo 16-18hr    1518 embryo 18-20hr    1342 embryo 20-22hr    1409 embryo 22-24hr    1918 larva L1    1167 larva L2    1279 larva L3 12hr old    1143 larva L3 puffstage 1-2    1366 larva L3 puffstage 3-6    2192 larva L3 puffstage 7-9    3196 white prepupae new    2808 white prepupae 12hr    2542 white prepupae 24hr    2837 pupae 2d postWPP    2870 pupae 3d postWPP    2368 pupae 4d postWPP    2537 adult male 01day    2478 adult male 05day    2577 adult male 30day    2060 adult female 01day    1386 adult female 05day    2795 adult female 30day    2444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3714) embryo 02-04hr  (2903) embryo 04-06hr  (3611) embryo 06-08hr  (3187) embryo 08-10hr  (3415) embryo 10-12hr  (2350) embryo 12-14hr  (2775) embryo 14-16hr  (1175) embryo 16-18hr  (1518) embryo 18-20hr  (1342) embryo 20-22hr  (1409) embryo 22-24hr  (1918) larva L1  (1167) larva L2  (1279) larva L3 12hr old  (1143) larva L3 puffstage 1-2  (1366) larva L3 puffstage 3-6  (2192) larva L3 puffstage 7-9  (3196) white prepupae new  (2808) white prepupae 12hr  (2542) white prepupae 24hr  (2837) pupae 2d postWPP  (2870) pupae 3d postWPP  (2368) pupae 4d postWPP  (2537) adult male 01day  (2478) adult male 05day  (2577) adult male 30day  (2060) adult female 01day  (1386) adult female 05day  (2795) adult female 30day  (2444) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3714) embryo 02-04hr  (2903) embryo 04-06hr  (3611) embryo 06-08hr  (3187) embryo 08-10hr  (3415) embryo 10-12hr  (2350) embryo 12-14hr  (2775) embryo 14-16hr    1175 embryo 16-18hr  (1518) embryo 18-20hr    1342 embryo 20-22hr  1409 embryo 22-24hr  (1918) larva L1    1167 larva L2    1279 larva L3 12hr old    1143 larva L3 puffstage 1-2    1366 larva L3 puffstage 3-6  (2192) larva L3 puffstage 7-9  (3196) white prepupae new  (2808) white prepupae 12hr  (2542) white prepupae 24hr  (2837) pupae 2d postWPP  (2870) pupae 3d postWPP  (2368) pupae 4d postWPP  (2537) adult male 01day  (2478) adult male 05day  (2577) adult male 30day  (2060) adult female 01day    1386 adult female 05day  (2795) adult female 30day  (2444) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3714 embryo 02-04hr    2903 embryo 04-06hr    3611 embryo 06-08hr    3187 embryo 08-10hr    3415 embryo 10-12hr    2350 embryo 12-14hr    2775 embryo 14-16hr    1175 embryo 16-18hr    1518 embryo 18-20hr    1342 embryo 20-22hr    1409 embryo 22-24hr    1918 larva L1    1167 larva L2    1279 larva L3 12hr old    1143 larva L3 puffstage 1-2    1366 larva L3 puffstage 3-6    2192 larva L3 puffstage 7-9    3196 white prepupae new    2808 white prepupae 12hr    2542 white prepupae 24hr    2837 pupae 2d postWPP    2870 pupae 3d postWPP    2368 pupae 4d postWPP    2537 adult male 01day    2478 adult male 05day    2577 adult male 30day    2060 adult female 01day    1386 adult female 05day    2795 adult female 30day    2444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3714 embryo 02-04hr    2903 embryo 04-06hr    3611 embryo 06-08hr    3187 embryo 08-10hr    3415 embryo 10-12hr    2350 embryo 12-14hr    2775 embryo 14-16hr    1175 embryo 16-18hr    1518 embryo 18-20hr    1342 embryo 20-22hr    1409 embryo 22-24hr    1918 larva L1    1167 larva L2    1279 larva L3 12hr old    1143 larva L3 puffstage 1-2    1366 larva L3 puffstage 3-6    2192 larva L3 puffstage 7-9    3196 white prepupae new    2808 white prepupae 12hr    2542 white prepupae 24hr    2837 pupae 2d postWPP    2870 pupae 3d postWPP    2368 pupae 4d postWPP    2537 adult male 01day    2478 adult male 05day    2577 adult male 30day    2060 adult female 01day    1386 adult female 05day    2795 adult female 30day    2444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032956 expression level Developmental Stage   Expression Level embryo 00-02hr    3714 embryo 02-04hr    2903 embryo 04-06hr    3611 embryo 06-08hr    3187 embryo 08-10hr    3415 embryo 10-12hr    2350 embryo 12-14hr    2775 embryo 14-16hr    1175 embryo 16-18hr    1518 embryo 18-20hr    1342 embryo 20-22hr    1409 embryo 22-24hr    1918 larva L1    1167 larva L2    1279 larva L3 12hr old    1143 larva L3 puffstage 1-2    1366 larva L3 puffstage 3-6    2192 larva L3 puffstage 7-9    3196 white prepupae new    2808 white prepupae 12hr    2542 white prepupae 24hr    2837 pupae 2d postWPP    2870 pupae 3d postWPP    2368 pupae 4d postWPP    2537 adult male 01day    2478 adult male 05day    2577 adult male 30day    2060 adult female 01day    1386 adult female 05day    2795 adult female 30day    2444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3714) embryo 02-04hr  (2903) embryo 04-06hr  (3611) embryo 06-08hr  (3187) embryo 08-10hr  (3415) embryo 10-12hr  (2350) embryo 12-14hr  (2775) embryo 14-16hr  (1175) embryo 16-18hr  (1518) embryo 18-20hr  (1342) embryo 20-22hr  (1409) embryo 22-24hr  (1918) larva L1  (1167) larva L2  (1279) larva L3 12hr old  (1143) larva L3 puffstage 1-2  (1366) larva L3 puffstage 3-6  (2192) larva L3 puffstage 7-9  (3196) white prepupae new  (2808) white prepupae 12hr  (2542) white prepupae 24hr  (2837) pupae 2d postWPP  (2870) pupae 3d postWPP  (2368) pupae 4d postWPP  (2537) adult male 01day  (2478) adult male 05day  (2577) adult male 30day  (2060) adult female 01day  (1386) adult female 05day  (2795) adult female 30day  (2444) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3714) embryo 02-04hr  (2903) embryo 04-06hr  (3611) embryo 06-08hr  (3187) embryo 08-10hr  (3415) embryo 10-12hr  2350 embryo 12-14hr  (2775) embryo 14-16hr    1175 embryo 16-18hr  1518 embryo 18-20hr    1342 embryo 20-22hr  1409 embryo 22-24hr  1918 larva L1    1167 larva L2    1279 larva L3 12hr old    1143 larva L3 puffstage 1-2    1366 larva L3 puffstage 3-6  2192 larva L3 puffstage 7-9  (3196) white prepupae new  (2808) white prepupae 12hr  (2542) white prepupae 24hr  (2837) pupae 2d postWPP  (2870) pupae 3d postWPP  2368 pupae 4d postWPP  (2537) adult male 01day  (2478) adult male 05day  (2577) adult male 30day  2060 adult female 01day    1386 adult female 05day  (2795) adult female 30day  2444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3714 embryo 02-04hr    2903 embryo 04-06hr    3611 embryo 06-08hr    3187 embryo 08-10hr    3415 embryo 10-12hr    2350 embryo 12-14hr    2775 embryo 14-16hr    1175 embryo 16-18hr    1518 embryo 18-20hr    1342 embryo 20-22hr    1409 embryo 22-24hr    1918 larva L1    1167 larva L2    1279 larva L3 12hr old    1143 larva L3 puffstage 1-2    1366 larva L3 puffstage 3-6    2192 larva L3 puffstage 7-9    3196 white prepupae new    2808 white prepupae 12hr    2542 white prepupae 24hr    2837 pupae 2d postWPP    2870 pupae 3d postWPP    2368 pupae 4d postWPP    2537 adult male 01day    2478 adult male 05day    2577 adult male 30day    2060 adult female 01day    1386 adult female 05day    2795 adult female 30day    2444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3714 embryo 02-04hr    2903 embryo 04-06hr    3611 embryo 06-08hr    3187 embryo 08-10hr    3415 embryo 10-12hr    2350 embryo 12-14hr    2775 embryo 14-16hr    1175 embryo 16-18hr    1518 embryo 18-20hr    1342 embryo 20-22hr    1409 embryo 22-24hr    1918 larva L1    1167 larva L2    1279 larva L3 12hr old    1143 larva L3 puffstage 1-2    1366 larva L3 puffstage 3-6    2192 larva L3 puffstage 7-9    3196 white prepupae new    2808 white prepupae 12hr    2542 white prepupae 24hr    2837 pupae 2d postWPP    2870 pupae 3d postWPP    2368 pupae 4d postWPP    2537 adult male 01day    2478 adult male 05day    2577 adult male 30day    2060 adult female 01day    1386 adult female 05day    2795 adult female 30day    2444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032956    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032956 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032956 expression level Tissue   Expression Level Larval Central Nervous System    315.95 Larval Midgut    86 Larval Hindgut    205.4 Larval Malpighian Tubules    174.8 Larval Fat Body    418.1 Larval Salivary Gland    225.9 Larval Trachea    102.15 Larval Carcass    239.875 Adult Head    156.2 Adult Eye    78.975 Adult Brain    279.6 Adult Thoracic-Abdominal Ganglion    204.4 Adult Crop    226 Adult Midgut    101.9 Adult Hindgut    145.8 Adult Malpighian Tubules    212.5 Adult Fat Body    239.1 Adult Salivary Gland    121 Adult Heart    113.75 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    210.9 Adult Ovary    472.4 Adult Testis    348.3 Adult Male Accessory Gland    145.5 Adult Carcass    166 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    315.95 Larval Midgut    86 Larval Hindgut    205.4 Larval Malpighian Tubules    174.8 Larval Fat Body    418.1 Larval Salivary Gland    225.9 Larval Trachea    102.15 Larval Carcass    239.875 Adult Head    156.2 Adult Eye    78.975 Adult Brain    279.6 Adult Thoracic-Abdominal Ganglion    204.4 Adult Crop    226 Adult Midgut    101.9 Adult Hindgut    145.8 Adult Malpighian Tubules    212.5 Adult Fat Body    239.1 Adult Salivary Gland    121 Adult Heart    113.75 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    210.9 Adult Ovary    472.4 Adult Testis    348.3 Adult Male Accessory Gland    145.5 Adult Carcass    166 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    315.95 Larval Midgut    86 Larval Hindgut    205.4 Larval Malpighian Tubules    174.8 Larval Fat Body    418.1 Larval Salivary Gland    225.9 Larval Trachea    102.15 Larval Carcass    239.875 Adult Head    156.2 Adult Eye    78.975 Adult Brain    279.6 Adult Thoracic-Abdominal Ganglion    204.4 Adult Crop    226 Adult Midgut    101.9 Adult Hindgut    145.8 Adult Malpighian Tubules    212.5 Adult Fat Body    239.1 Adult Salivary Gland    121 Adult Heart    113.75 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    210.9 Adult Ovary    472.4 Adult Testis    348.3 Adult Male Accessory Gland    145.5 Adult Carcass    166 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    315.95 Larval Midgut    86 Larval Hindgut    205.4 Larval Malpighian Tubules    174.8 Larval Fat Body    418.1 Larval Salivary Gland    225.9 Larval Trachea    102.15 Larval Carcass    239.875 Adult Head    156.2 Adult Eye    78.975 Adult Brain    279.6 Adult Thoracic-Abdominal Ganglion    204.4 Adult Crop    226 Adult Midgut    101.9 Adult Hindgut    145.8 Adult Malpighian Tubules    212.5 Adult Fat Body    239.1 Adult Salivary Gland    121 Adult Heart    113.75 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    210.9 Adult Ovary    472.4 Adult Testis    348.3 Adult Male Accessory Gland    145.5 Adult Carcass    166 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032956 expression level Tissue   Expression Level Larval Central Nervous System    315.95 Larval Midgut    86 Larval Hindgut    205.4 Larval Malpighian Tubules    174.8 Larval Fat Body    418.1 Larval Salivary Gland    225.9 Larval Trachea    102.15 Larval Carcass    239.875 Adult Head    156.2 Adult Eye    78.975 Adult Brain    279.6 Adult Thoracic-Abdominal Ganglion    204.4 Adult Crop    226 Adult Midgut    101.9 Adult Hindgut    145.8 Adult Malpighian Tubules    212.5 Adult Fat Body    239.1 Adult Salivary Gland    121 Adult Heart    113.75 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    210.9 Adult Ovary    472.4 Adult Testis    348.3 Adult Male Accessory Gland    145.5 Adult Carcass    166 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    315.95 Larval Midgut    86 Larval Hindgut    205.4 Larval Malpighian Tubules    174.8 Larval Fat Body    418.1 Larval Salivary Gland    225.9 Larval Trachea    102.15 Larval Carcass    239.875 Adult Head    156.2 Adult Eye    78.975 Adult Brain    279.6 Adult Thoracic-Abdominal Ganglion    204.4 Adult Crop    226 Adult Midgut    101.9 Adult Hindgut    145.8 Adult Malpighian Tubules    212.5 Adult Fat Body    239.1 Adult Salivary Gland    121 Adult Heart    113.75 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    210.9 Adult Ovary    472.4 Adult Testis    348.3 Adult Male Accessory Gland    145.5 Adult Carcass    166 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    315.95 Larval Midgut    86 Larval Hindgut    205.4 Larval Malpighian Tubules    174.8 Larval Fat Body    418.1 Larval Salivary Gland    225.9 Larval Trachea    102.15 Larval Carcass    239.875 Adult Head    156.2 Adult Eye    78.975 Adult Brain    279.6 Adult Thoracic-Abdominal Ganglion    204.4 Adult Crop    226 Adult Midgut    101.9 Adult Hindgut    145.8 Adult Malpighian Tubules    212.5 Adult Fat Body    239.1 Adult Salivary Gland    121 Adult Heart    113.75 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    210.9 Adult Ovary    472.4 Adult Testis    348.3 Adult Male Accessory Gland    145.5 Adult Carcass    166 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    315.95 Larval Midgut    86 Larval Hindgut    205.4 Larval Malpighian Tubules    174.8 Larval Fat Body    418.1 Larval Salivary Gland    225.9 Larval Trachea    102.15 Larval Carcass    239.875 Adult Head    156.2 Adult Eye    78.975 Adult Brain    279.6 Adult Thoracic-Abdominal Ganglion    204.4 Adult Crop    226 Adult Midgut    101.9 Adult Hindgut    145.8 Adult Malpighian Tubules    212.5 Adult Fat Body    239.1 Adult Salivary Gland    121 Adult Heart    113.75 Adult VirginFemale Spermatheca    183.1 Adult InseminatedFemale Spermatheca    210.9 Adult Ovary    472.4 Adult Testis    348.3 Adult Male Accessory Gland    145.5 Adult Carcass    166 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    156.2   NA  Eye    78.975   NA  Brain    279.6   315.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    204.4   NA  Crop    226   86  Midgut    101.9   205.4  Hindgut    145.8   174.8  Malpighian Tubules    212.5   418.1  Fat Body    239.1   225.9  Salivary Gland    121   NA  Heart    113.75   102.15  Trachea    NA   NA  VirginFemale Spermatheca    183.1   NA  InseminatedFemale Spermatheca    210.9   NA  Ovary    472.4   NA  Testis    348.3   NA  Male Accessory Gland    145.5   239.875  Carcass    166 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032956 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1512-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 Cul-2GD8913 lethal | pupal stage, with Scer\GAL4pnr-MD237 Cul-2GD8913 lethal | recessive Cul-202074 Cul-205230 viable Cul-2EY09124 Sterility Allele female sterile Cul-2EY09124 fertile Cul-2EY09124 Other Phenotypes Allele neuroanatomy defective, with Scer\GAL4elav.PU Cul-2GD8913 neuroanatomy defective (with Cul-202074) Cul-2EY09124 neuroanatomy defective (with Cul-2EY09124) Cul-202074 neuroanatomy defective | larval stage, with Scer\GAL41407 Cul-2GD8913 visible, with Scer\GAL4pnr-MD237 Cul-2GD8913 Phenotype manifest in Allele egg chamber Cul-2EY09124 embryonic/larval neuroblast | larval stage, with Scer\GAL41407 Cul-2GD8913 ganglion mother cell | larval stage, with Scer\GAL41407 Cul-2GD8913 germarium Cul-2EY09124 interfollicle cell Cul-2EY09124 mesothoracic tergum, with Scer\GAL4pnr-MD237 Cul-2GD8913 NMJ bouton | larval stage | supernumerary, with Scer\GAL4elav.PU Cul-2GD8913 NMJ bouton | larval stage | supernumerary (with Cul-202074) Cul-2EY09124 NMJ bouton | larval stage | supernumerary (with Cul-2EY09124) Cul-202074 nurse cell Cul-2EY09124 oocyte Cul-2EY09124 terminal filament Cul-2EY09124
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Cul-2 Class Mutagen Stocks Known lesion Cul-202074 P-element activity 1 -- Cul-2EY09124 P-element activity 1 -- Cul-205230 P-element activity 0 -- Cul-2F33.8 spontaneous 0 Yes Cul-2SH0832 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cul-2 Class Mutagen Stocks Known lesion Cul-2GD8913 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Cul-2HM05237 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cul-2HMS01398 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cul-2KK100540 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)305 (Kerridge, 1996.11.6) Df(2L)BSC103 (Deal and Cook, 2005.3.10) Df(2L)Exel7082 (Ryder, 2004.4.26) Df(2L)TE38A-2 (Kerridge, 1996.11.6) Df(2L)TW65 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)TW161 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2L)TW158 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.HM05237} NA P{TRiP.HMS01398} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Cul-2SH0832 No P{lacW}l(2)SH2339SH2339 No P{PZ}Cul-202074 No P{PZ}Cul-205230 No insertion of mobile activating element P{EPgy2}Cul-2EY09124 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
growth of a germarium-derived egg chamber inferred from mutant phenotype (Ayyub, 2011) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (Ayyub, 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ubiquitin protein ligase binding inferred from electronic annotation with InterPro:IPR001373, InterPro:IPR016157, InterPro:IPR016158, InterPro:IPR019559 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
ubiquitin-dependent protein catabolic process inferred from electronic annotation with InterPro:IPR001373, InterPro:IPR016157, InterPro:IPR016158, InterPro:IPR019559 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cullin-RING ubiquitin ligase complex inferred from electronic annotation with InterPro:IPR001373, InterPro:IPR016157, InterPro:IPR016158, InterPro:IPR019559 (FlyBase Curators et al., 2004-) nuclear ubiquitin ligase complex inferred from sequence or structural similarity with EMBL:AF083216 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cul-2 allele Gene References cul-202074 tsh (Kerridge, 1996.11.6)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61365 DroID - A comprehensive database of gene and protein interactions. • FBgn0032956 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35420
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15487 Dere\GG21342 Dgri\GH10784 Dmoj\GI17442 Dper\GL25796 Dpse\GA13508 Dsec\GM16141 Dsim\GD24329 Dvir\GJ14230 Dyak\GE12924
Curated drosophilid orthologs	Dpse\GA13508
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006929-PA Aedes aegypti (mosquito) AGAP003605-PA Anopheles gambiae (mosquito) XP_001946605.1 Acyrthosiphon pisum (pea aphid) 84491 Batrachochytrium dendrobatidis (chytrid fungus) 89705 Branchiostoma floridae (lancelet) 91151 Branchiostoma floridae (lancelet) ENSBTAP00000051032 Bos taurus (bovine) CN19366 Caenorhabditis brenneri (small nematode) CBP29214 Caenorhabditis briggsae (nematode) CE32774 Caenorhabditis elegans (worm) ENSCAFP00000005533 Canis familiaris (dog) ENSCINP00000004560 Ciona intestinalis (sea squirt) ENSCPOP00000001536 Cavia porcellus (guinea pig) RP44281 Caenorhabditis remanei (nematode) ENSCSAVP00000004060 Ciona savignyi (sedentary tunicate) 175514 Capitella spl (polychaete worm) 255909 Daphnia pulex (daphnia) ENSDARP00000016182 Danio rerio (zebra fish) ENSECAP00000013580 Equus caballus (horse) XP_652906 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000002274 Gymnopilus aculeatus (mushroom) ENSGALP00000011473 Gallus gallus (chicken) 190953 Hypsipyla robusta (cedar shoot borer) ENSP00000363880 Homo sapiens (human) ISCW021256-PA Ixodes scapularis (deer tick) 207667 Lottia gigantea (owl limpet) ENSMODP00000008610 Monodelphis domestica (gray opossum) ENSMMUP00000036016 Macaca mulatta (rhesus monkey) ENSMUSP00000078988 Mus musculus (house mouse) 178205 Nematostella vectensis (starlet anemone) XP_001599116.1 Nasonia vitripennis (wasp) ENSOANP00000009681 Ornithorynchus anatinus (platypus) ENSORLP00000006015 Oryzias latipes (japanese killifish) PHUM002468-PA Pediculus humanus (human body louse) PP29376 Pristionchus pacificus (nematode) ENSPPYP00000022294 Pongo pygmaeus (orangutan) ENSPTRP00000004129 Pan troglodytes (chimpanzee) ENSRNOP00000051033 Rattus norvegicus (norway rat) Smp_079740 Schistosoma mansoni (trematode parasite) 22645 Trichoplax adhaerens (metazoa) XP_974579.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011574 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000029922 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000019375 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19007 NV18061 LH24642 ISCW021256 FBgn0230638 FBgn0201445 FBgn0195676 FBgn0171057 JGI_V11_255909 JGI_V11_58155 FBgn0073544 FBgn0163380 FBgn0140186 FBgn0118265 FBgn0113521 FBgn0092512 ACYPI005859 ACYPI002700 GB15833 AGAP003605 AAEL006929 PHUM422860 GLEAN_15524
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	11176 P{PZ}Cul-202074 cn1/CyO; ry506 19883 y1 w67c23; P{EPgy2}Cul-2EY09124 34988 y1 sc* v1; P{TRiP.HMS01398}attP2 30494 y1 sc* v1; P{TRiP.HM05237}attP2/TM3, Sb1
VDRC	v105101 P{KK100540}VIE-260B v19297 w1118; P{GD8913}v19297 v19298 w1118; P{GD8913}v19298
Genomic Clones ( 1 )
	BACR12I17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 63 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD36177
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH27670 GM08061 LP20416 RE05854 RE10203 RE30408 RE32951 RE33024 RE70662 SD12925 SD23575
Other clones	883 44839 52828 57028 71818 78489 194522 214213.12 214311.10 214319.19 214321.8 214385.7 556924 bs59c11 CK01.6D.F10 CK01.23B.F4 CK01.26C.C8 CK01.74C.E1 CK01.86A.C2 CK01.94C.F8 CK01.95B.C3 CK01.109D.C7 EK010241 EK021254 EK028641 EK058517 EK073656 EK074110 EK099112 EK121710 EK164164 EK167607 EK168544 EK170342 EK182901 EK200156 EK207928 EK244609 EK254562 EK297340 EP02448 EP03430 EP04738 EP15845 EP18420 FGM003G06 IP17679 IP17879 IP17979 LD38431 SD05653
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032956 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35420
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Cul-2 cul-2 (FlyBase, 2009-)
Source for database merge of	Source for merge of: cul-2 l(2)02074 (Khush, 2003.2.25)
Additional comments	Renamed to be consistent with FlyBase nomenclature rules. (FlyBase, 2009-) "l(2)02074" probably corresponds to "CG1512"; the P{PZ} insertion in the "l(2)0207402074" allele maps only 24bp upstream of the 5' end of the CT3821 transcript of "CG1512". (Misra, 2000.8.25)
Other Comments
	S2 cells are treated with dsRNA made from templates generated with primers directed against this gene to assess effect on degradation of dup and geminin genes. (Higa et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136273 NM_165390 RefSeq (Proteins) • NP_610117 NP_724352 DDBJ / EMBL / GenBank • AAF57224 AAG22124 AAL28982 AI456285 AW943328 AY061434 CL705836 G00597 Entrez Gene - A searchable database of RefSeq genes. • 35420 UniProtKB/TrEMBL • Q9V9R2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cullin, N-terminal (IPR001373) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991) Cullin, conserved site (IPR016157) Cullin homology (IPR016158) Cullin repeat-like-containing domain (IPR016159) Cullin protein, neddylation domain (IPR019559)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61365 DroID - A comprehensive database of gene and protein interactions. • FBgn0032956 DRSC - Results from RNAi screens. • FBgn0032956 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032956 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1512-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032956 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35420 InParanoid A subset of ortholog calls from InParanoid. • AAEL006929-PA Aedes aegypti (mosquito) AGAP003605-PA Anopheles gambiae (mosquito) XP_001946605.1 Acyrthosiphon pisum (pea aphid) 84491 Batrachochytrium dendrobatidis (chytrid fungus) 89705 Branchiostoma floridae (lancelet) 91151 Branchiostoma floridae (lancelet) ENSBTAP00000051032 Bos taurus (bovine) CN19366 Caenorhabditis brenneri (small nematode) CBP29214 Caenorhabditis briggsae (nematode) CE32774 Caenorhabditis elegans (worm) ENSCAFP00000005533 Canis familiaris (dog) ENSCINP00000004560 Ciona intestinalis (sea squirt) ENSCPOP00000001536 Cavia porcellus (guinea pig) RP44281 Caenorhabditis remanei (nematode) ENSCSAVP00000004060 Ciona savignyi (sedentary tunicate) 175514 Capitella spl (polychaete worm) 255909 Daphnia pulex (daphnia) ENSDARP00000016182 Danio rerio (zebra fish) ENSECAP00000013580 Equus caballus (horse) XP_652906 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000002274 Gymnopilus aculeatus (mushroom) ENSGALP00000011473 Gallus gallus (chicken) 190953 Hypsipyla robusta (cedar shoot borer) ENSP00000363880 Homo sapiens (human) ISCW021256-PA Ixodes scapularis (deer tick) 207667 Lottia gigantea (owl limpet) ENSMODP00000008610 Monodelphis domestica (gray opossum) ENSMMUP00000036016 Macaca mulatta (rhesus monkey) ENSMUSP00000078988 Mus musculus (house mouse) 178205 Nematostella vectensis (starlet anemone) XP_001599116.1 Nasonia vitripennis (wasp) ENSOANP00000009681 Ornithorynchus anatinus (platypus) ENSORLP00000006015 Oryzias latipes (japanese killifish) PHUM002468-PA Pediculus humanus (human body louse) PP29376 Pristionchus pacificus (nematode) ENSPPYP00000022294 Pongo pygmaeus (orangutan) ENSPTRP00000004129 Pan troglodytes (chimpanzee) ENSRNOP00000051033 Rattus norvegicus (norway rat) Smp_079740 Schistosoma mansoni (trematode parasite) 22645 Trichoplax adhaerens (metazoa) XP_974579.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011574 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000029922 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000019375 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35420 modMine - Data generated by the modENCODE project. • FBgn0032956 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19007 NV18061 LH24642 ISCW021256 FBgn0230638 FBgn0201445 FBgn0195676 FBgn0171057 JGI_V11_255909 JGI_V11_58155 FBgn0073544 FBgn0163380 FBgn0140186 FBgn0118265 FBgn0113521 FBgn0092512 ACYPI005859 ACYPI002700 GB15833 AGAP003605 AAEL006929 PHUM422860 GLEAN_15524
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG1512 (Donaldson et al., 2004, Khush, 2003.2.25, Ou et al., 2002, Misra, 2000.8.25, Perkins et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Makunin and Yurlova, 2010, Makunin and Yurlova, 2010) CUL2 (Higa et al., 2003) Cul2 (Ou et al., 2003, Zhu et al., 2005, Reynolds et al., 2008) Cul-2 (Wasbrough et al., 2010) cul-2 (Haag-Liautard et al., 2007, Zhang et al., 2007, Akdemir et al., 2007, Neumüller et al., 2011, Ayyub, 2011) cul2 (Ayyub, 2011) DMcul-2 (Filippov et al., 2000) l(2)02074 (Khush, 2003.2.25, Misra, 2000.8.25, Spradling et al., 1999, Kerridge, 1996.11.6, BDGP Project Members, 1994-1999, )
Name Synonym	cul-2   Cullin-2
Secondary FlyBase IDs
	FBgn0010507
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 12 ) FlyBase analysis  ( 3 ) Computer file  ( 3 ) Curated genome annotation  ( 1 )
Recent research papers ( 4 )
	Ayyub, 2011, J. Genet. 90(2): 239--249 Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila. [FBrf0214802] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Makunin and Yurlova, 2010, Russ. J. Genet. 46(9): 1067--1069 LTR retrotransposons as source of promoters in the drosophila genome. [FBrf0215194] Makunin and Yurlova, 2010, Genetika, Moscow 46(9): 1202--1204 [LTR retrotransposons as source of promoters in the Drosophila genome]. [FBrf0212258] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...