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Gene Dmel\RpL21

General Information
Symbol	Dmel\RpL21	Species	D. melanogaster
Name	Ribosomal protein L21	Annotation symbol	CG12775
Feature type	protein_coding_gene	FlyBase ID	FBgn0032987
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	40F6-40F6	Sequence location	2L:22,247,111..22,247,833 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ribosomal protein L21 is referred to in FlyBase by the symbol Dmel\RpL21 (CG12775, FBgn0032987). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: structural constituent of ribosome. There is experimental evidence that it is involved in the biological process: mitotic spindle elongation; mitotic spindle organization; centrosome duplication. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Ribosomal protein L21e; Ribosomal protein L21e, conserved site; Translation protein SH3-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636712_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RpL21. Gene sequence location is 2L:22247111..22247833.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood ribosome day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood References Alonso and Santaren, 2006, J. Proteome Res. 5(8): 2025--2032
FB2012_01	References Müller et al., 2010, EMBO J. 29(19): 3344--3357 Sequence features HFA03704 BKN20357 Controlled Vocabulary Terms centrosome duplication
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 40F6-40F6   Limits computationally determined from genome sequence between P{lacW}Df31k05815 and P{PZ}cul-202074&P{lacW}l(2)k08110k08110
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RpL21 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RpL21-RA FBtr0085961  NM_136300   649   159
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RpL21-PA   FBpp0085314   18.5   159   11.23     NP_610144   AAF57259
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L21e, conserved site (IPR018259) Ribosomal protein L21e (IPR001147) Translation protein SH3-like (IPR008991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202820   AA246819   AA391773   AA539507   AA539981   AA567152   AA567271   AA567286   AA695929   AA696222   AA802428   AA802547   AA803105   AA803777   AA941437   AE014134 AAF57259   AF083276   AF083277   AI106665   AI108496   AI109217   AI114133   AI134235   AI134523   AI135954   AI257005   AI259552   AI292540   AI293957   AI295976   AI386911   AI387392   AI404107   AI513057   AI519484   AI520487   AI530752   AI534459   AI546656   AY071556 AAL49178   AY231806   AY232061   BE975378   BG635654   BG636204   BG637326   BG637614   BG640689   BG640886   BI142217   BI161519   BI161627   BI161628   BI162842   BI163048   BI163153   BI163816   BI164288   BI165429   BI166736   BI167409   BI167563   BI167712   BI169714   BI171620   BI171894   BI212441   BI213142   BI213897   BI215910   BI216443   BI227906   BI228598   BI228718   BI230224   BI230395   BI231327   BI231416   BI232335   BI234633   BI235281   BI236728   BI239823   BI241271   BI241282   BI241832   BI243446   BI352216   BI352753   BI352852   BI353416   BI353790   BI354043   BI354070   BI354838   BI355731   BI356806   BI361414   BI361955   BI363588   BI364869   BI369518   BI369519   BI369898   BI369930   BI370703   BI371024   BI371060   BI371162   BI371361   BI372513   BI374867   BI374893   BI481923   BI482243   BI483717   BI483931   BI484609   BI485376   BI487167   BI563372   BI564031   BI564196   BI564211   BI565126   BI565167   BI565340   BI565445   BI566054   BI566319   BI566360   BI566536   BI566756   BI566949   BI567020   BI567284   BI567293   BI567306   BI567398   BI567495   BI567542   BI567777   BI567779   BI567888   BI568429   BI568504   BI569244   BI569245   BI569374   BI569375   BI569589   BI569799   BI569823   BI569998   BI570017   BI570077   BI570388   BI570439   BI572699   BI573561   BI573562   BI573767   BI573768   BI574475   BI574499   BI575204   BI575238   BI575240   BI575497   BI575655   BI575739   BI575988   BI576019   BI576024   BI576435   BI576626   BI576754   BI576843   BI577238   BI578768   BI581565   BI582979   BI583040   BI583103   BI584169   BI584339   BI584584   BI584730   BI585053   BI585068   BI585176   BI585909   BI586481   BI586518   BI587174   BI587264   BI587315   BI587959   BI588694   BI588997   BI589009   BI589031   BI589118   BI589218   BI589330   BI589565   BI589930   BI590043   BI590045   BI590115   BI590530   BI591664   BI592191   BI592386   BI592761   BI604305   BI604597   BI604642   BI605166   BI605433   BI605636   BI606913   BI607477   BI607791   BI608747   BI608800   BI611228   BI611553   BI613210   BI613356   BI613564   BI613639   BI614679   BI615002   BI615208   BI615533   BI615766   BI615935   BI616121   BI616787   BI617605   BI618121   BI618694   BI619062   BI619276   BI619342   BI619535   BI620340   BI620484   BI620742   BI621162   BI621237   BI621892   BI623021   BI623071   BI623339   BI623362   BI623689   BI624313   BI624556   BI624760   BI625661   BI626319   BI626840   BI626890   BI626925   BI627330   BI628317   BI628427   BI628530   BI628761   BI630057   BI630644   BI631056   BI631748   BI632359   BI632816   BI634089   BI634236   BI634479   BI634678   BI634733   BI634882   BI635145   BI635664   BI636518   BI637129   BI637547   BI640048   BP540340   BP540341   BP540924   BP540925   BP540985   BP540986   BP541139   BP541140   BP541378   BP541626   BP541648   BP541892   BP542068   BP542927   BP542928   BP542984   BP542985   BP543737   BP543738   BP544246   BP544247   BP544918   BP544919   BP545242   BP545243   BP545362   BP545363   BP545877   BP546421   BP546450   BP547158   BP547215   BP547254   BP548370   BP548886   BP549437   BP549438   BP549448   BP549943   BP550788   BP550789   BP551034   BP551035   BP551379   BP551380   BP552671   BP552672   BP553002   BP553003   BP553583   BP553584   BP553717   BP553718   BP556190   BP556191   BP556376   BP556377   BP556431   BP556432   BP556674   BP556675   BP559061   BP559062   BP559524   BP560174   BP560175   BT001760 AAN71515   CA805297   CK445205   CK658490   CK662193   CK662219   CO152817   CO152964   CO153124   CO153825   CO153840   CO153994   CO154125   CO154553   CO154655   CO154871   CO155191   CO155581   CO155732   CO155859   CO155951   CO156368   CO156419   CO156626   CO156656   CO156710   CO156840   CO156950   CO179888   CO180064   CO180073   CO184107   CO185224   CO191201   CO191472   CO191654   CO194500   CO194573   CO195592   CO195715   CO195752   CO267116   CO273039   CO273651   CO274975   CO279600   CO285330   CO294638   CO299080   CO308277   CO312017   CO319885   CO319896   CO323874   CO329243   CO332959   CO333195   CO335459   CO335906   CO336189   CO336265   CO336336   CO336473   CO336611   CO336662   CO337160   CO337769   CO337815   CO338296   CO338327   CO338409   CO338628   CO338716   DN154149   EC060428   EC074018   EC077660   EC078577   EC084395   EC086925   EC198040   EC198324   EC201401   EC203315   EC223759   EC228292   EC237995   EC239799   EC245738   EC250445   EC250639   EC260829   EC261152   EC261646   EC261685   EC261700   EC261749   EC261856   EC261935   EC261989   EC262032   EC262307   EC262781   EC262836   EC263032   EC263262   EC263577   EC263907   EC264133   EC264390   EC264879   EC264889   EC265061   EC266223   EC266399   EC266517   EC266712   EC266723   EC266744   EC267046   EC267431   EC267615   EC267786   EC267890   EC267961   EV575355   EV578953   EV579160   EV579504   EV580908   EV581216   EV582898   EV585115   EV586584   EV586594   EV587689   EV590982   EV593529   EV593532   EV594714   EV594812   EV594990   EV595130   EV595812   EV598214   GH739302   GH739634   GH740414   GH740934   GH743532   GH743746   GH744194   GH744524   GH745433   GH745881   GH763223   GH763904   GH764240   GH765314   GH766530   GH766842   GH767151   GH779446   GH779499   GH779668
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V9M7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032987    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032987 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032987 expression level Developmental Stage   Expression Level embryo 00-02hr    93101 embryo 02-04hr    155950 embryo 04-06hr    194852 embryo 06-08hr    177774 embryo 08-10hr    226495 embryo 10-12hr    324786 embryo 12-14hr    180424 embryo 14-16hr    130281 embryo 16-18hr    157987 embryo 18-20hr    121748 embryo 20-22hr    145232 embryo 22-24hr    194330 larva L1    159287 larva L2    149505 larva L3 12hr old    115459 larva L3 puffstage 1-2    109103 larva L3 puffstage 3-6    88908 larva L3 puffstage 7-9    112938 white prepupae new    103627 white prepupae 12hr    98687 white prepupae 24hr    97874 pupae 2d postWPP    83773 pupae 3d postWPP    69883 pupae 4d postWPP    54414 adult male 01day    46067 adult male 05day    40174 adult male 30day    43779 adult female 01day    91637 adult female 05day    118095 adult female 30day    114329 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (93101) embryo 02-04hr  (155950) embryo 04-06hr  (194852) embryo 06-08hr  (177774) embryo 08-10hr  (226495) embryo 10-12hr  (324786) embryo 12-14hr  (180424) embryo 14-16hr  (130281) embryo 16-18hr  (157987) embryo 18-20hr  (121748) embryo 20-22hr  (145232) embryo 22-24hr  (194330) larva L1  (159287) larva L2  (149505) larva L3 12hr old  (115459) larva L3 puffstage 1-2  (109103) larva L3 puffstage 3-6  (88908) larva L3 puffstage 7-9  (112938) white prepupae new  (103627) white prepupae 12hr  (98687) white prepupae 24hr  (97874) pupae 2d postWPP  (83773) pupae 3d postWPP  (69883) pupae 4d postWPP  (54414) adult male 01day  (46067) adult male 05day  (40174) adult male 30day  (43779) adult female 01day  (91637) adult female 05day  (118095) adult female 30day  (114329) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (93101) embryo 02-04hr  (155950) embryo 04-06hr  (194852) embryo 06-08hr  (177774) embryo 08-10hr  (226495) embryo 10-12hr  (324786) embryo 12-14hr  (180424) embryo 14-16hr  (130281) embryo 16-18hr  (157987) embryo 18-20hr  (121748) embryo 20-22hr  (145232) embryo 22-24hr  (194330) larva L1  (159287) larva L2  (149505) larva L3 12hr old  (115459) larva L3 puffstage 1-2  (109103) larva L3 puffstage 3-6  (88908) larva L3 puffstage 7-9  (112938) white prepupae new  (103627) white prepupae 12hr  (98687) white prepupae 24hr  (97874) pupae 2d postWPP  (83773) pupae 3d postWPP  (69883) pupae 4d postWPP  (54414) adult male 01day  (46067) adult male 05day  (40174) adult male 30day  (43779) adult female 01day  (91637) adult female 05day  (118095) adult female 30day  (114329) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (93101) embryo 02-04hr  (155950) embryo 04-06hr  (194852) embryo 06-08hr  (177774) embryo 08-10hr  (226495) embryo 10-12hr  (324786) embryo 12-14hr  (180424) embryo 14-16hr  (130281) embryo 16-18hr  (157987) embryo 18-20hr  (121748) embryo 20-22hr  (145232) embryo 22-24hr  (194330) larva L1  (159287) larva L2  (149505) larva L3 12hr old  (115459) larva L3 puffstage 1-2  (109103) larva L3 puffstage 3-6  (88908) larva L3 puffstage 7-9  (112938) white prepupae new  (103627) white prepupae 12hr  (98687) white prepupae 24hr  (97874) pupae 2d postWPP  (83773) pupae 3d postWPP  (69883) pupae 4d postWPP  (54414) adult male 01day  (46067) adult male 05day  (40174) adult male 30day  (43779) adult female 01day  (91637) adult female 05day  (118095) adult female 30day  (114329) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    93101 embryo 02-04hr    155950 embryo 04-06hr    194852 embryo 06-08hr    177774 embryo 08-10hr    226495 embryo 10-12hr    324786 embryo 12-14hr    180424 embryo 14-16hr    130281 embryo 16-18hr    157987 embryo 18-20hr    121748 embryo 20-22hr    145232 embryo 22-24hr    194330 larva L1    159287 larva L2    149505 larva L3 12hr old    115459 larva L3 puffstage 1-2    109103 larva L3 puffstage 3-6    88908 larva L3 puffstage 7-9    112938 white prepupae new    103627 white prepupae 12hr    98687 white prepupae 24hr    97874 pupae 2d postWPP    83773 pupae 3d postWPP    69883 pupae 4d postWPP    54414 adult male 01day    46067 adult male 05day    40174 adult male 30day    43779 adult female 01day    91637 adult female 05day    118095 adult female 30day    114329 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032987 expression level Developmental Stage   Expression Level embryo 00-02hr    93101 embryo 02-04hr    155950 embryo 04-06hr    194852 embryo 06-08hr    177774 embryo 08-10hr    226495 embryo 10-12hr    324786 embryo 12-14hr    180424 embryo 14-16hr    130281 embryo 16-18hr    157987 embryo 18-20hr    121748 embryo 20-22hr    145232 embryo 22-24hr    194330 larva L1    159287 larva L2    149505 larva L3 12hr old    115459 larva L3 puffstage 1-2    109103 larva L3 puffstage 3-6    88908 larva L3 puffstage 7-9    112938 white prepupae new    103627 white prepupae 12hr    98687 white prepupae 24hr    97874 pupae 2d postWPP    83773 pupae 3d postWPP    69883 pupae 4d postWPP    54414 adult male 01day    46067 adult male 05day    40174 adult male 30day    43779 adult female 01day    91637 adult female 05day    118095 adult female 30day    114329 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (93101) embryo 02-04hr  (155950) embryo 04-06hr  (194852) embryo 06-08hr  (177774) embryo 08-10hr  (226495) embryo 10-12hr  (324786) embryo 12-14hr  (180424) embryo 14-16hr  (130281) embryo 16-18hr  (157987) embryo 18-20hr  (121748) embryo 20-22hr  (145232) embryo 22-24hr  (194330) larva L1  (159287) larva L2  (149505) larva L3 12hr old  (115459) larva L3 puffstage 1-2  (109103) larva L3 puffstage 3-6  (88908) larva L3 puffstage 7-9  (112938) white prepupae new  (103627) white prepupae 12hr  (98687) white prepupae 24hr  (97874) pupae 2d postWPP  (83773) pupae 3d postWPP  (69883) pupae 4d postWPP  (54414) adult male 01day  (46067) adult male 05day  (40174) adult male 30day  (43779) adult female 01day  (91637) adult female 05day  (118095) adult female 30day  (114329) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (93101) embryo 02-04hr  (155950) embryo 04-06hr  (194852) embryo 06-08hr  (177774) embryo 08-10hr  (226495) embryo 10-12hr  (324786) embryo 12-14hr  (180424) embryo 14-16hr  (130281) embryo 16-18hr  (157987) embryo 18-20hr  (121748) embryo 20-22hr  (145232) embryo 22-24hr  (194330) larva L1  (159287) larva L2  (149505) larva L3 12hr old  (115459) larva L3 puffstage 1-2  (109103) larva L3 puffstage 3-6  (88908) larva L3 puffstage 7-9  (112938) white prepupae new  (103627) white prepupae 12hr  (98687) white prepupae 24hr  (97874) pupae 2d postWPP  (83773) pupae 3d postWPP  (69883) pupae 4d postWPP  (54414) adult male 01day  (46067) adult male 05day  (40174) adult male 30day  (43779) adult female 01day  (91637) adult female 05day  (118095) adult female 30day  (114329) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (93101) embryo 02-04hr  (155950) embryo 04-06hr  (194852) embryo 06-08hr  (177774) embryo 08-10hr  (226495) embryo 10-12hr  (324786) embryo 12-14hr  (180424) embryo 14-16hr  (130281) embryo 16-18hr  (157987) embryo 18-20hr  (121748) embryo 20-22hr  (145232) embryo 22-24hr  (194330) larva L1  (159287) larva L2  (149505) larva L3 12hr old  (115459) larva L3 puffstage 1-2  (109103) larva L3 puffstage 3-6  (88908) larva L3 puffstage 7-9  (112938) white prepupae new  (103627) white prepupae 12hr  (98687) white prepupae 24hr  (97874) pupae 2d postWPP  (83773) pupae 3d postWPP  (69883) pupae 4d postWPP  (54414) adult male 01day  (46067) adult male 05day  (40174) adult male 30day  (43779) adult female 01day  (91637) adult female 05day  (118095) adult female 30day  (114329) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    93101 embryo 02-04hr    155950 embryo 04-06hr    194852 embryo 06-08hr    177774 embryo 08-10hr    226495 embryo 10-12hr    324786 embryo 12-14hr    180424 embryo 14-16hr    130281 embryo 16-18hr    157987 embryo 18-20hr    121748 embryo 20-22hr    145232 embryo 22-24hr    194330 larva L1    159287 larva L2    149505 larva L3 12hr old    115459 larva L3 puffstage 1-2    109103 larva L3 puffstage 3-6    88908 larva L3 puffstage 7-9    112938 white prepupae new    103627 white prepupae 12hr    98687 white prepupae 24hr    97874 pupae 2d postWPP    83773 pupae 3d postWPP    69883 pupae 4d postWPP    54414 adult male 01day    46067 adult male 05day    40174 adult male 30day    43779 adult female 01day    91637 adult female 05day    118095 adult female 30day    114329 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032987    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032987 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032987 expression level Tissue   Expression Level Larval Central Nervous System    2862.225 Larval Midgut    4529.7 Larval Hindgut    4618.3 Larval Malpighian Tubules    5451 Larval Fat Body    7254.2 Larval Salivary Gland    7222.8 Larval Trachea    5873 Larval Carcass    4886.75 Adult Head    4660.2 Adult Eye    7493.175 Adult Brain    3528.6 Adult Thoracic-Abdominal Ganglion    4878.6 Adult Crop    5828.1 Adult Midgut    4970 Adult Hindgut    5111.2 Adult Malpighian Tubules    6320.5 Adult Fat Body    5985.2 Adult Salivary Gland    12873.3 Adult Heart    6708.375 Adult VirginFemale Spermatheca    4868.4 Adult InseminatedFemale Spermatheca    5037.6 Adult Ovary    3421.5 Adult Testis    1271.7 Adult Male Accessory Gland    8370.3 Adult Carcass    5368.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2862.225) Larval Midgut  (4529.7) Larval Hindgut  (4618.3) Larval Malpighian Tubules  (5451) Larval Fat Body  (7254.2) Larval Salivary Gland  (7222.8) Larval Trachea  (5873) Larval Carcass  (4886.75) Adult Head  (4660.2) Adult Eye  (7493.175) Adult Brain  (3528.6) Adult Thoracic-Abdominal Ganglion  (4878.6) Adult Crop  (5828.1) Adult Midgut  (4970) Adult Hindgut  (5111.2) Adult Malpighian Tubules  (6320.5) Adult Fat Body  (5985.2) Adult Salivary Gland  (12873.3) Adult Heart  (6708.375) Adult VirginFemale Spermatheca  (4868.4) Adult InseminatedFemale Spermatheca  (5037.6) Adult Ovary  (3421.5) Adult Testis  (1271.7) Adult Male Accessory Gland  (8370.3) Adult Carcass  (5368.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2862.225) Larval Midgut  (4529.7) Larval Hindgut  (4618.3) Larval Malpighian Tubules  (5451) Larval Fat Body  (7254.2) Larval Salivary Gland  (7222.8) Larval Trachea  (5873) Larval Carcass  (4886.75) Adult Head  (4660.2) Adult Eye  (7493.175) Adult Brain  (3528.6) Adult Thoracic-Abdominal Ganglion  (4878.6) Adult Crop  (5828.1) Adult Midgut  (4970) Adult Hindgut  (5111.2) Adult Malpighian Tubules  (6320.5) Adult Fat Body  (5985.2) Adult Salivary Gland  (12873.3) Adult Heart  (6708.375) Adult VirginFemale Spermatheca  (4868.4) Adult InseminatedFemale Spermatheca  (5037.6) Adult Ovary  (3421.5) Adult Testis  (1271.7) Adult Male Accessory Gland  (8370.3) Adult Carcass  (5368.2) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2862.225 Larval Midgut    4529.7 Larval Hindgut    4618.3 Larval Malpighian Tubules    5451 Larval Fat Body    7254.2 Larval Salivary Gland    7222.8 Larval Trachea    5873 Larval Carcass    4886.75 Adult Head    4660.2 Adult Eye    7493.175 Adult Brain    3528.6 Adult Thoracic-Abdominal Ganglion    4878.6 Adult Crop    5828.1 Adult Midgut    4970 Adult Hindgut    5111.2 Adult Malpighian Tubules    6320.5 Adult Fat Body    5985.2 Adult Salivary Gland    12873.3 Adult Heart    6708.375 Adult VirginFemale Spermatheca    4868.4 Adult InseminatedFemale Spermatheca    5037.6 Adult Ovary    3421.5 Adult Testis    1271.7 Adult Male Accessory Gland    8370.3 Adult Carcass    5368.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032987 expression level Tissue   Expression Level Larval Central Nervous System    2862.225 Larval Midgut    4529.7 Larval Hindgut    4618.3 Larval Malpighian Tubules    5451 Larval Fat Body    7254.2 Larval Salivary Gland    7222.8 Larval Trachea    5873 Larval Carcass    4886.75 Adult Head    4660.2 Adult Eye    7493.175 Adult Brain    3528.6 Adult Thoracic-Abdominal Ganglion    4878.6 Adult Crop    5828.1 Adult Midgut    4970 Adult Hindgut    5111.2 Adult Malpighian Tubules    6320.5 Adult Fat Body    5985.2 Adult Salivary Gland    12873.3 Adult Heart    6708.375 Adult VirginFemale Spermatheca    4868.4 Adult InseminatedFemale Spermatheca    5037.6 Adult Ovary    3421.5 Adult Testis    1271.7 Adult Male Accessory Gland    8370.3 Adult Carcass    5368.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2862.225) Larval Midgut  (4529.7) Larval Hindgut  (4618.3) Larval Malpighian Tubules  (5451) Larval Fat Body  (7254.2) Larval Salivary Gland  (7222.8) Larval Trachea  (5873) Larval Carcass  (4886.75) Adult Head  (4660.2) Adult Eye  (7493.175) Adult Brain  (3528.6) Adult Thoracic-Abdominal Ganglion  (4878.6) Adult Crop  (5828.1) Adult Midgut  (4970) Adult Hindgut  (5111.2) Adult Malpighian Tubules  (6320.5) Adult Fat Body  (5985.2) Adult Salivary Gland  (12873.3) Adult Heart  (6708.375) Adult VirginFemale Spermatheca  (4868.4) Adult InseminatedFemale Spermatheca  (5037.6) Adult Ovary  (3421.5) Adult Testis  (1271.7) Adult Male Accessory Gland  (8370.3) Adult Carcass  (5368.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2862.225) Larval Midgut  (4529.7) Larval Hindgut  (4618.3) Larval Malpighian Tubules  (5451) Larval Fat Body  (7254.2) Larval Salivary Gland  (7222.8) Larval Trachea  (5873) Larval Carcass  (4886.75) Adult Head  (4660.2) Adult Eye  (7493.175) Adult Brain  (3528.6) Adult Thoracic-Abdominal Ganglion  (4878.6) Adult Crop  (5828.1) Adult Midgut  (4970) Adult Hindgut  (5111.2) Adult Malpighian Tubules  (6320.5) Adult Fat Body  (5985.2) Adult Salivary Gland  (12873.3) Adult Heart  (6708.375) Adult VirginFemale Spermatheca  (4868.4) Adult InseminatedFemale Spermatheca  (5037.6) Adult Ovary  (3421.5) Adult Testis  1271.7 Adult Male Accessory Gland  (8370.3) Adult Carcass  (5368.2) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2862.225 Larval Midgut    4529.7 Larval Hindgut    4618.3 Larval Malpighian Tubules    5451 Larval Fat Body    7254.2 Larval Salivary Gland    7222.8 Larval Trachea    5873 Larval Carcass    4886.75 Adult Head    4660.2 Adult Eye    7493.175 Adult Brain    3528.6 Adult Thoracic-Abdominal Ganglion    4878.6 Adult Crop    5828.1 Adult Midgut    4970 Adult Hindgut    5111.2 Adult Malpighian Tubules    6320.5 Adult Fat Body    5985.2 Adult Salivary Gland    12873.3 Adult Heart    6708.375 Adult VirginFemale Spermatheca    4868.4 Adult InseminatedFemale Spermatheca    5037.6 Adult Ovary    3421.5 Adult Testis    1271.7 Adult Male Accessory Gland    8370.3 Adult Carcass    5368.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4660.2   NA  Eye    7493.175   NA  Brain    3528.6   2862.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4878.6   NA  Crop    5828.1   4529.7  Midgut    4970   4618.3  Hindgut    5111.2   5451  Malpighian Tubules    6320.5   7254.2  Fat Body    5985.2   7222.8  Salivary Gland    12873.3   NA  Heart    6708.375   5873  Trachea    NA   NA  VirginFemale Spermatheca    4868.4   NA  InseminatedFemale Spermatheca    5037.6   NA  Ovary    3421.5   NA  Testis    1271.7   NA  Male Accessory Gland    8370.3   4886.75  Carcass    5368.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_22
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032987 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12775-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 RpL21GD7827 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of RpL21 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RpL21 Class Mutagen Stocks Known lesion RpL21GD7827 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RpL21KK100261 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7827} NA P{KK100261} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
centrosome duplication inferred from mutant phenotype (Müller et al., 2010) mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Cermelli et al., 2006) ribosome inferred from direct assay (Alonso and Santaren, 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from electronic annotation with InterPro:IPR001147, InterPro:IPR018259 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
translation inferred from electronic annotation with InterPro:IPR001147, InterPro:IPR018259 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytosolic large ribosomal subunit inferred from sequence or structural similarity with UniProtKB:P20280 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RpL21 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61391 DroID - A comprehensive database of gene and protein interactions. • FBgn0032987 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35453
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22757 Dere\GG21369 Dgri\GH13288 Dmoj\GI17481 Dper\GL21175 Dpse\GA11806 Dsec\GM18795 Dsim\GD24352 Dvir\GJ15013 Dwil\GK19074 Dyak\GE12955
Curated drosophilid orthologs	Dpse\GA11806 (Yasuhara et al., 2005, ) Dyak\GE12955
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007715-PA Aedes aegypti (mosquito) AGAP012138-PA Anopheles gambiae (mosquito) XP_001120360.1 Apis mellifera (honey bee) XP_001952183.1 Acyrthosiphon pisum (pea aphid) At1g57660.1 Arabidopsis thaliana (wall cress) At1g57860.1 Arabidopsis thaliana (wall cress) 30914 Batrachochytrium dendrobatidis (chytrid fungus) 117218 Branchiostoma floridae (lancelet) 125590 Branchiostoma floridae (lancelet) XP_001900950.1 Brugia malayi (roundworm nematode) BGIBMGA001106-PA Bombyx mori (silk worm) ENSBTAP00000002160 Bos taurus (bovine) CAL0002747 Candida albicans (a form of yeast) CN08724 Caenorhabditis brenneri (small nematode) CBP04036 Caenorhabditis briggsae (nematode) CE00078 Caenorhabditis elegans (worm) ENSCAFP00000011720 Canis familiaris (dog) ENSCAFP00000017412 Canis familiaris (dog) CAGL0M06523g Candida glabrata (haploid yeast) Chro.60285 Cryptosporidium hominis (obligate parasite) ENSCINP00000022064 Ciona intestinalis (sea squirt) JA00138 Caenorhabditis japonica (nematode) CMR150C Cyanidioschyzon merolae (red alga) cn05221 Cryptococcus neoformans (yeast-like fungus) cgd6_2460 Cryptosporidium parvum (protozoan parasite) CPIJ002183 Culex pipens (mosquito) ENSCPOP00000018273 Cavia porcellus (guinea pig) 24354 Chlamidomonas reinhardtii (green alga) RP18103 Caenorhabditis remanei (nematode) ENSCSAVP00000016700 Ciona savignyi (sedentary tunicate) 159819 Capitella spl (polychaete worm) DDB0229962 Dictyostelium discoideum (amoeba) DEHA2B04928g Debaryomyces Hansenii (yeast) DEHA2C07920g Debaryomyces Hansenii (yeast) 305566 Daphnia pulex (daphnia) ENSDARP00000016158 Danio rerio (zebra fish) ENSECAP00000000816 Equus caballus (horse) ENSECAP00000008633 Equus caballus (horse) XP_655158 Entamoeba histolytica (anaerobic protozoan) XP_655273 Entamoeba histolytica (anaerobic protozoan) XP_655492 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000004068 Gymnopilus aculeatus (mushroom) ENSGALP00000029462 Gallus gallus (chicken) GL50803_15520 Giardia lamblia (flagellated protozoan) 103188 Hypsipyla robusta (cedar shoot borer) ENSP00000346027 Homo sapiens (human) ISCW017347-PA Ixodes scapularis (deer tick) KLLA0E23651g Kluyveromyces lactis (yeast) 226411 Lottia gigantea (owl limpet) LmjF16.0460 Leishmania major (virus) LmjF34.3650 Leishmania major (virus) 16125 Monocosta brevicollis (choanoflagellate) ENSMODP00000011120 Monodelphis domestica (gray opossum) ENSMODP00000029125 Monodelphis domestica (gray opossum) ENSMMUP00000030762 Macaca mulatta (rhesus monkey) ENSMMUP00000031864 Macaca mulatta (rhesus monkey) ENSMMUP00000032135 Macaca mulatta (rhesus monkey) ENSMMUP00000033495 Macaca mulatta (rhesus monkey) ENSMMUP00000038242 Macaca mulatta (rhesus monkey) ENSMUSP00000041652 Mus musculus (house mouse) ENSMUSP00000076636 Mus musculus (house mouse) ENSMUSP00000082241 Mus musculus (house mouse) ENSMUSP00000082360 Mus musculus (house mouse) ENSMUSP00000087218 Mus musculus (house mouse) 237086 Nematostella vectensis (starlet anemone) XP_001608245.1 Nasonia vitripennis (wasp) ENSOANP00000014414 Ornithorynchus anatinus (platypus) ENSORLP00000011048 Oryzias latipes (japanese killifish) LOC_Os03g04750.1 Oryza sativa (asian rice) LOC_Os10g32820.1 Oryza sativa (asian rice) 23086 Ostreococcus tauri (green alga) PF14_0240 Plasmodium falciparum (protozoal parasite) PHUM006839-PA Pediculus humanus (human body louse) PP02507 Pristionchus pacificus (nematode) 106900 Physcomitrella patens (moss) 158496 Physcomitrella patens (moss) 171540 Physcomitrella patens (moss) 213645 Physcomitrella patens (moss) ENSPPYP00000005578 Pongo pygmaeus (orangutan) ENSPPYP00000005960 Pongo pygmaeus (orangutan) 71550 Phytophthora ramorum (sudden oak death pathogen) 127040 Phytophthora sojae (root rot pathogen) 817491 Populus trichocarpa (black cottonwood) ENSPTRP00000009758 Pan troglodytes (chimpanzee) PVX_085225 Plasmodium vivax (protozoal parasite) ENSRNOP00000001265 Rattus norvegicus (norway rat) ENSRNOP00000039786 Rattus norvegicus (norway rat) ENSRNOP00000041966 Rattus norvegicus (norway rat) ENSRNOP00000046409 Rattus norvegicus (norway rat) ENSRNOP00000048808 Rattus norvegicus (norway rat) ENSRNOP00000051312 Rattus norvegicus (norway rat) 147299 Sorghum bicolor (sorghum) 4745904 Sorghum bicolor (sorghum) YBR191W Saccharomyces cerevisiae (budding yeast) YPL079W Saccharomyces cerevisiae (budding yeast) Smp_022560.2 Schistosoma mansoni (trematode parasite) SPAC959.08 Schizosaccharomyces pombe (fission yeast) SPBC365.03c Schizosaccharomyces pombe (fission yeast) XP_783316.1 Strongylocentrotus purpuratus (purple sea urchin) 37276 Trichoplax adhaerens (metazoa) TA15220 Theileria annulata (apicomplexan parasite) XP_974171.1 Tribolium castaneum (red flour beetle) Tc00.1047053506405.149 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507251.20 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000002780 Tetraodon nigroviridis (green spotted pufferfish) TP02_0089 Theileria parva (parasitic protozoan) 29007 Thalassiosira pseudonana (marine diatom) ENSTRUP00000012160 Takifugu rubripes (pufferfish Takifugu) 99.m00148 Tetrahymena thermophila (ciliate protozoa) 84270.m00583 Trichomonas vaginalis (parasitic flagellated protozoan) 85052.m00062 Trichomonas vaginalis (parasitic flagellated protozoan) 88043.m00116 Trichomonas vaginalis (parasitic flagellated protozoan) 89444.m00058 Trichomonas vaginalis (parasitic flagellated protozoan) 95694.m00039 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000021590 Xenopus tropicalis (frog) YALI0F05522g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12200 NV10368 LH19278 ISCW017347 FBgn0068456 FBgn0221072 FBgn0202212 FBgn0195699 FBgn0173700 JGI_V11_305566 FBgn0071855 FBgn0158769 FBgn0140225 FBgn0120764 FBgn0113548 FBgn0099751 CPIJ002183 BGIBMGA001106 ACYPI006688 GB16182 AGAP012138 AAEL007715 PHUM122500 GLEAN_07932
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v105819 P{KK100261}VIE-260B v32016 w1118; P{GD7827}v32016
Genomic Clones ( 2 )
	BACR13A13 BACR13E23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 484 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE62581 RH06526
Other clones	yak-ad_CG12775 yak-em_CG12775
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH07342 GH08341 GH11635 GH12011 GH15465 GH17911 GH23706 GM01144 GM02253 GM02270 GM04785 GM05318 GM05542 GM07013 GM15273 GM18345 GM20605 GM21069 GM23540 GM25141 GM26078 GM26173 GM28543 GM32126 LD05807 LD17669 LD19293 LD39093 LD40664 LD45278 LP02987 LP07228 LP22225 LP22264 RE02085 RE02484 RE03328 RE03938 RE05329 RE07790 RE07970 RE08156 RE10972 RE13784 RE18479 RE19535 RE20778 RE21478 RE22678 RE23578 RE25292 RE26186 RE31107 RE32835 RE36418 RE38302 RE38314 RE39014 RE41090 RE43028 RE45620 RE46387 RE48461 RE50060 RE56235 RE57424 RE58001 RE59492 RE66641 RE66901 RE67738 RE68689 RE70682 RE70891 RH01980 RH02247 RH02325 RH02706 RH02771 RH03596 RH03688 RH09827 RH13437 RH13502 RH17884 RH23687 RH23828 RH24516 RH25610 RH27789 RH29786 RH30095 RH30643 RH31582 RH32042 RH32491 RH39140 RH42316 RH42494 RH42742 RH44126 RH45205 RH50586 RH51946 RH52550 RH56015 RH56826 RH56962 RH62817 RH67907 RH67996 RH69618 SD01309 SD07282 SD09840 SD11829 SD13121 SD13813 SD15246 SD16252 SD16393 SD17078 SD18222 SD19051 SD19588 SD22815 SD26122 SD26690
Other clones	9853 11105 21153 34097 52907 55353 65584 75464 77071 125904 147610 153735 176543 176571 190045 280335 281230 473680 521744 522076 522865 523027 523167 523870 523979 524164 524203 524520 525023 525522 525647 527775 527912 528053 528162 528295 533502 533901 542843 557086 557164 557751 557888 562226 569619 569661 571246 571279 571370 572860 575640 bs41h11 Dmel_dig_007388_0583_2013 Dmel_dig_008725_0700_1534 Dmel_dig_008847_0694_1323 Dmel_dig_013891_0683_0665 Dmel_dig_014600_0608_1920 Dmel_dig_015527_0639_2126 Dmel_dig_018440_0634_0585 Dmel_dig_019789_0595_3486 Dmel_neb_010923_0910_1284 Dmel_neb_012365_0622_1327 Dmel_neb_012479_0073_2844 Dmel_neb_012694_0666_1885 Dmel_neb_012695_0140_2213 Dmel_neb_012882_0141_3093 Dmel_neb_013141_0691_2767 Dmel_neb_014162_0626_1515 Dmel_neb_014400_0571_1455 Dmel_neb_015382_0407_1958 Dmel_neb_015703_0616_1284 Dmel_neb_015803_0700_0509 EC00449 EC00849 EC00860 EC27128 EC29959 EC30428 EC31130 EC31613 EC38668 EC38828 EC40629 EC40829 EC40885 EK109332 EK111739 EK116102 EK135450 EK148750 EK168755 EK174450 EK191801 EK191856 EK207338 EK227708 EK257339 EK281315 EK281335 EK292333 EK305242 EK306158 EN00516 EN00940 EN01327 EN02908 EN02926 EN03250 EN03538 EN04343 EN04537 EN04945 EN05537 EN06353 EN06638 EN06855 EN07106 EN07929 EN08030 EN08432 EN08508 EN08650 EN09417 EN09635 EN10360 EN11450 EN12023 EN12158 EN12329 EN12613 EN12905 EN13002 EN13938 EN15252 EN15341 EN16427 EN16515 EN16729 EN17225 EN17454 ESG0117c.B21_B03 FGA002D09 FGA009A11 FGA009F04 FGA011A01 FGC001A04 FGC003F10 FGC003H08 FGC006F10 FGC008G04 FGC017G01 FGC018A06 FGC022B03 FGC024H02 FGC028E05 FGC030C03 FGC030H05 FGH001E03 FGH106C03 FGH106E08 FGH114A08 FGH114F05 FGH115A08 FGH127A11 FGM002D05 FGM101E05 FGM101E10 FGM104D05 FGM209B04 FGM210E11 FGM212E09 FGM220B02 FGM222A07 FGM225B11 FGM225H08 FGM301H07 FGM303B06 FGM303E02 FGM304H06 FGM318F06 FGM321D09 FGM325B01 GH06736 GH10826 GH13885 GH17295 GM05802 GM14242 LD03152 LD11530 LD25574 LP04285 LP09755 LP14342 LP15436 RE01023 RE01087 RE02346 RE06944 RE10194 RE13434 RE17534 RE26349 RE28384 RE30366 RE55726 RE55727 RE56272 RE57823 RE57872 RE58236 RE62552 RE64546 RE64905 RE72684 RH01377 RH01462 RH01688 RH01952 RH02222 RH03013 RH03455 RH03594 RH04163 RH08309 RH09154 RH09286 RH10054 RH10539 RH11730 RH17407 RH19078 RH21408 RH21473 RH21553 RH23149 RH23519 RH23994 RH24276 RH24536 RH24652 RH26433 RH26476 RH27661 RH27857 RH28894 RH29703 RH29772 RH30660 RH30702 RH30802 RH31178 RH31416 RH31742 RH32428 RH32484 RH32993 RH33225 RH33384 RH33484 RH34001 RH35153 RH35531 RH35580 RH35707 RH35945 RH35966 RH36212 RH36490 RH36760 RH36847 RH37193 RH37296 RH37412 RH37431 RH37658 RH37770 RH37903 RH37960 RH38358 RH38360 RH38592 RH38643 RH38881 RH38951 RH39874 RH40071 RH42841 RH44516 RH44781 RH45516 RH45844 RH45980 RH46860 RH47989 RH48675 RH49575 RH50027 RH50278 RH50360 RH51461 RH51642 RH52464 RH53446 RH55077 RH55142 RH55477 RH55546 RH56683 RH57504 RH59019 RH59926 RH60461 RH61386 RH62862 RH63093 RH63221 RH63853 RH64135 RH64410 RH66129 RH67002 RH68059 RH68611 RH70020 RH70074 RH70706 RH71030 RH71473 RH73767 RH74554 RP001006371 RP001006519 RP001011193 RP001015519 RP001016116 RP001021199 RP001021424 RP001021931 RP001025861 RP001032087 RP001032669 RP001032948 RP001033532 RP001033617 RP001034292 RP001040522 RP001040788 RP001044068 RP001051865 RP001054698 SD12054
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032987 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35453
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG12775 anon-EST:Posey18 (Bayraktaroglu, 2000.11.2) Source for merge of: CG12775 BcDNA:RH06526 (FlyBase, 1996-)
Additional comments	"RpL21" likely corresponds to "M(2)39F". (Marygold et al., 2007) Source for merge of CG12775 BcDNA:RH06526 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) Likely Minute gene. (Marygold et al., 2007) Deletions removing RpL21 but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes. (Marygold et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136300 RefSeq (Proteins) • NP_610144 DDBJ / EMBL / GenBank • AAF57259 AAL49178 AAN71515 AF083276 AF083277 AY071556 BI374893 BI591664 BT001760 Entrez Gene - A searchable database of RefSeq genes. • 35453 UniProtKB/TrEMBL • Q9V9M7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L21e, conserved site (IPR018259) Ribosomal protein L21e (IPR001147) Translation protein SH3-like (IPR008991)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61391 DroID - A comprehensive database of gene and protein interactions. • FBgn0032987 DRSC - Results from RNAi screens. • FBgn0032987 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032987 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12775-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032987 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35453 InParanoid A subset of ortholog calls from InParanoid. • AAEL007715-PA Aedes aegypti (mosquito) AGAP012138-PA Anopheles gambiae (mosquito) XP_001120360.1 Apis mellifera (honey bee) XP_001952183.1 Acyrthosiphon pisum (pea aphid) At1g57660.1 Arabidopsis thaliana (wall cress) At1g57860.1 Arabidopsis thaliana (wall cress) 30914 Batrachochytrium dendrobatidis (chytrid fungus) 117218 Branchiostoma floridae (lancelet) 125590 Branchiostoma floridae (lancelet) XP_001900950.1 Brugia malayi (roundworm nematode) BGIBMGA001106-PA Bombyx mori (silk worm) ENSBTAP00000002160 Bos taurus (bovine) CAL0002747 Candida albicans (a form of yeast) CN08724 Caenorhabditis brenneri (small nematode) CBP04036 Caenorhabditis briggsae (nematode) CE00078 Caenorhabditis elegans (worm) ENSCAFP00000011720 Canis familiaris (dog) ENSCAFP00000017412 Canis familiaris (dog) CAGL0M06523g Candida glabrata (haploid yeast) Chro.60285 Cryptosporidium hominis (obligate parasite) ENSCINP00000022064 Ciona intestinalis (sea squirt) JA00138 Caenorhabditis japonica (nematode) CMR150C Cyanidioschyzon merolae (red alga) cn05221 Cryptococcus neoformans (yeast-like fungus) cgd6_2460 Cryptosporidium parvum (protozoan parasite) CPIJ002183 Culex pipens (mosquito) ENSCPOP00000018273 Cavia porcellus (guinea pig) 24354 Chlamidomonas reinhardtii (green alga) RP18103 Caenorhabditis remanei (nematode) ENSCSAVP00000016700 Ciona savignyi (sedentary tunicate) 159819 Capitella spl (polychaete worm) DDB0229962 Dictyostelium discoideum (amoeba) DEHA2B04928g Debaryomyces Hansenii (yeast) DEHA2C07920g Debaryomyces Hansenii (yeast) 305566 Daphnia pulex (daphnia) ENSDARP00000016158 Danio rerio (zebra fish) ENSECAP00000000816 Equus caballus (horse) ENSECAP00000008633 Equus caballus (horse) XP_655158 Entamoeba histolytica (anaerobic protozoan) XP_655273 Entamoeba histolytica (anaerobic protozoan) XP_655492 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000004068 Gymnopilus aculeatus (mushroom) ENSGALP00000029462 Gallus gallus (chicken) GL50803_15520 Giardia lamblia (flagellated protozoan) 103188 Hypsipyla robusta (cedar shoot borer) ENSP00000346027 Homo sapiens (human) ISCW017347-PA Ixodes scapularis (deer tick) KLLA0E23651g Kluyveromyces lactis (yeast) 226411 Lottia gigantea (owl limpet) LmjF16.0460 Leishmania major (virus) LmjF34.3650 Leishmania major (virus) 16125 Monocosta brevicollis (choanoflagellate) ENSMODP00000011120 Monodelphis domestica (gray opossum) ENSMODP00000029125 Monodelphis domestica (gray opossum) ENSMMUP00000030762 Macaca mulatta (rhesus monkey) ENSMMUP00000031864 Macaca mulatta (rhesus monkey) ENSMMUP00000032135 Macaca mulatta (rhesus monkey) ENSMMUP00000033495 Macaca mulatta (rhesus monkey) ENSMMUP00000038242 Macaca mulatta (rhesus monkey) ENSMUSP00000041652 Mus musculus (house mouse) ENSMUSP00000076636 Mus musculus (house mouse) ENSMUSP00000082241 Mus musculus (house mouse) ENSMUSP00000082360 Mus musculus (house mouse) ENSMUSP00000087218 Mus musculus (house mouse) 237086 Nematostella vectensis (starlet anemone) XP_001608245.1 Nasonia vitripennis (wasp) ENSOANP00000014414 Ornithorynchus anatinus (platypus) ENSORLP00000011048 Oryzias latipes (japanese killifish) LOC_Os03g04750.1 Oryza sativa (asian rice) LOC_Os10g32820.1 Oryza sativa (asian rice) 23086 Ostreococcus tauri (green alga) PF14_0240 Plasmodium falciparum (protozoal parasite) PHUM006839-PA Pediculus humanus (human body louse) PP02507 Pristionchus pacificus (nematode) 106900 Physcomitrella patens (moss) 158496 Physcomitrella patens (moss) 171540 Physcomitrella patens (moss) 213645 Physcomitrella patens (moss) ENSPPYP00000005578 Pongo pygmaeus (orangutan) ENSPPYP00000005960 Pongo pygmaeus (orangutan) 71550 Phytophthora ramorum (sudden oak death pathogen) 127040 Phytophthora sojae (root rot pathogen) 817491 Populus trichocarpa (black cottonwood) ENSPTRP00000009758 Pan troglodytes (chimpanzee) PVX_085225 Plasmodium vivax (protozoal parasite) ENSRNOP00000001265 Rattus norvegicus (norway rat) ENSRNOP00000039786 Rattus norvegicus (norway rat) ENSRNOP00000041966 Rattus norvegicus (norway rat) ENSRNOP00000046409 Rattus norvegicus (norway rat) ENSRNOP00000048808 Rattus norvegicus (norway rat) ENSRNOP00000051312 Rattus norvegicus (norway rat) 147299 Sorghum bicolor (sorghum) 4745904 Sorghum bicolor (sorghum) YBR191W Saccharomyces cerevisiae (budding yeast) YPL079W Saccharomyces cerevisiae (budding yeast) Smp_022560.2 Schistosoma mansoni (trematode parasite) SPAC959.08 Schizosaccharomyces pombe (fission yeast) SPBC365.03c Schizosaccharomyces pombe (fission yeast) XP_783316.1 Strongylocentrotus purpuratus (purple sea urchin) 37276 Trichoplax adhaerens (metazoa) TA15220 Theileria annulata (apicomplexan parasite) XP_974171.1 Tribolium castaneum (red flour beetle) Tc00.1047053506405.149 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507251.20 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000002780 Tetraodon nigroviridis (green spotted pufferfish) TP02_0089 Theileria parva (parasitic protozoan) 29007 Thalassiosira pseudonana (marine diatom) ENSTRUP00000012160 Takifugu rubripes (pufferfish Takifugu) 99.m00148 Tetrahymena thermophila (ciliate protozoa) 84270.m00583 Trichomonas vaginalis (parasitic flagellated protozoan) 85052.m00062 Trichomonas vaginalis (parasitic flagellated protozoan) 88043.m00116 Trichomonas vaginalis (parasitic flagellated protozoan) 89444.m00058 Trichomonas vaginalis (parasitic flagellated protozoan) 95694.m00039 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000021590 Xenopus tropicalis (frog) YALI0F05522g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35453 modMine - Data generated by the modENCODE project. • FBgn0032987 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12200 NV10368 LH19278 ISCW017347 FBgn0068456 FBgn0221072 FBgn0202212 FBgn0195699 FBgn0173700 JGI_V11_305566 FBgn0071855 FBgn0158769 FBgn0140225 FBgn0120764 FBgn0113548 FBgn0099751 CPIJ002183 BGIBMGA001106 ACYPI006688 GB16182 AGAP012138 AAEL007715 PHUM122500 GLEAN_07932
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	anon-EST:Posey18   anon-EST:Posey30   BcDNA:RH06526   CG12775 (Boutros et al., 2004, King et al., 2002.9.23, Cermelli et al., 2006, Goshima et al., 2007, Marygold et al., 2007, Keleman et al., 2009.8.5, Cammarato et al., 2011) RpL21 (Cermelli et al., 2006, Goshima et al., 2007, Marygold et al., 2007, Zhou et al., 2008) RPL21 (Pinnola et al., 2007) Rp L21 (Alonso and Santaren, 2006)
Name Synonym	Ribosomal protein L21 (Ashburner and Marygold, 2004.7.2, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBan0012775 FBgn0026278 FBgn0064845
References ( 27 )
Generate a list of	All references relating to this gene ( 27 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 2 ) Computer file  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Müller et al., 2010, EMBO J. 29(19): 3344--3357 Proteomic and functional analysis of the mitotic Drosophila centrosome. [FBrf0212030] Show all research papers ...