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Gene Dmel\CG10465

General Information
Symbol	Dmel\CG10465	Species	D. melanogaster
Name		Annotation symbol	CG10465
Feature type	protein_coding_gene	FlyBase ID	FBgn0033017
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	41E5-41E5	Sequence location	2R:1,227,207..1,228,496 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG10465 (FBgn0033017). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: voltage-gated potassium channel activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: potassium ion transport. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: BTB/POZ fold; BTB/POZ-like; Potassium channel, voltage dependent, Kv, tetramerisation. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult Malpighian tubules, larval fat body, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, larval/adult hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640138_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG10465. Gene sequence location is 2R:1227207..1228496.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA04848 BKN20092
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 41E5-41E5   Limits computationally determined from genome sequence between P{PZ}vlc07022&P{lacW}l(2)09851k08138 and P{PZ}l(2)0985109851&P{lacW}Src42Ak10108
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG10465 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG10465-RA FBtr0086094  NM_136321   1241   301
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG10465-PA   FBpp0085430   34.0   301   6.40     NP_610165   AAF57336
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Potassium channel, voltage dependent, Kv, tetramerisation (IPR003131) BTB/POZ fold (IPR011333)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392960   AA536453   AA695879   AE013599 AAF57336   AI513466   AI945006   AY071521 AAL49143   AY232114   BI362951   BI370484   BI641666   BP547406   CO178014   CO186508   CO193695   CO264583   CO266066   CO269822   CO281175   CO285794   CO288692   CO288723   CO292314   CO294252   CO294628   CO299630   CO309840   CO331480   CO331938   EC060913   EC062235   EC067479   EC070177   EC075060   EC195994   EC201443   EC201509   EC203046   EC205226   EC212713   EC214416   EC219025   EC220063   EC225011   EC233485   EC237554   EC240715   EC245120   EC247408   EC250961   FE862803   FE862849   FE862900   FE862949   FE863082   FE863138   GH739997   GH740865   GH741358   GH741786   GH744123   GH744623   GH745299   GH745671   GH747467   GH762186   GH763895   GH764923   GH765804   GH766098   GH766564   GH767496   GH767937   GH768723   GH769658   GH779475   GO254344
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JZ62
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033017    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033017 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033017 expression level Developmental Stage   Expression Level embryo 00-02hr    4396 embryo 02-04hr    6269 embryo 04-06hr    5573 embryo 06-08hr    3665 embryo 08-10hr    4597 embryo 10-12hr    3094 embryo 12-14hr    5126 embryo 14-16hr    1449 embryo 16-18hr    2494 embryo 18-20hr    1409 embryo 20-22hr    2203 embryo 22-24hr    3673 larva L1    1241 larva L2    1845 larva L3 12hr old    1259 larva L3 puffstage 1-2    1974 larva L3 puffstage 3-6    2270 larva L3 puffstage 7-9    4061 white prepupae new    3772 white prepupae 12hr    3461 white prepupae 24hr    3443 pupae 2d postWPP    3105 pupae 3d postWPP    2150 pupae 4d postWPP    925 adult male 01day    1829 adult male 05day    1463 adult male 30day    1114 adult female 01day    1179 adult female 05day    3715 adult female 30day    2933 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4396) embryo 02-04hr  (6269) embryo 04-06hr  (5573) embryo 06-08hr  (3665) embryo 08-10hr  (4597) embryo 10-12hr  (3094) embryo 12-14hr  (5126) embryo 14-16hr  (1449) embryo 16-18hr  (2494) embryo 18-20hr  (1409) embryo 20-22hr  (2203) embryo 22-24hr  (3673) larva L1  (1241) larva L2  (1845) larva L3 12hr old  (1259) larva L3 puffstage 1-2  (1974) larva L3 puffstage 3-6  (2270) larva L3 puffstage 7-9  (4061) white prepupae new  (3772) white prepupae 12hr  (3461) white prepupae 24hr  (3443) pupae 2d postWPP  (3105) pupae 3d postWPP  (2150) pupae 4d postWPP  (925) adult male 01day  (1829) adult male 05day  (1463) adult male 30day  (1114) adult female 01day  (1179) adult female 05day  (3715) adult female 30day  (2933) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4396) embryo 02-04hr  (6269) embryo 04-06hr  (5573) embryo 06-08hr  (3665) embryo 08-10hr  (4597) embryo 10-12hr  (3094) embryo 12-14hr  (5126) embryo 14-16hr  1449 embryo 16-18hr  (2494) embryo 18-20hr  1409 embryo 20-22hr  (2203) embryo 22-24hr  (3673) larva L1    1241 larva L2  (1845) larva L3 12hr old    1259 larva L3 puffstage 1-2  (1974) larva L3 puffstage 3-6  (2270) larva L3 puffstage 7-9  (4061) white prepupae new  (3772) white prepupae 12hr  (3461) white prepupae 24hr  (3443) pupae 2d postWPP  (3105) pupae 3d postWPP  (2150) pupae 4d postWPP    925 adult male 01day  (1829) adult male 05day  1463 adult male 30day    1114 adult female 01day    1179 adult female 05day  (3715) adult female 30day  (2933) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4396 embryo 02-04hr    6269 embryo 04-06hr    5573 embryo 06-08hr    3665 embryo 08-10hr    4597 embryo 10-12hr    3094 embryo 12-14hr    5126 embryo 14-16hr    1449 embryo 16-18hr    2494 embryo 18-20hr    1409 embryo 20-22hr    2203 embryo 22-24hr    3673 larva L1    1241 larva L2    1845 larva L3 12hr old    1259 larva L3 puffstage 1-2    1974 larva L3 puffstage 3-6    2270 larva L3 puffstage 7-9    4061 white prepupae new    3772 white prepupae 12hr    3461 white prepupae 24hr    3443 pupae 2d postWPP    3105 pupae 3d postWPP    2150 pupae 4d postWPP    925 adult male 01day    1829 adult male 05day    1463 adult male 30day    1114 adult female 01day    1179 adult female 05day    3715 adult female 30day    2933 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4396 embryo 02-04hr    6269 embryo 04-06hr    5573 embryo 06-08hr    3665 embryo 08-10hr    4597 embryo 10-12hr    3094 embryo 12-14hr    5126 embryo 14-16hr    1449 embryo 16-18hr    2494 embryo 18-20hr    1409 embryo 20-22hr    2203 embryo 22-24hr    3673 larva L1    1241 larva L2    1845 larva L3 12hr old    1259 larva L3 puffstage 1-2    1974 larva L3 puffstage 3-6    2270 larva L3 puffstage 7-9    4061 white prepupae new    3772 white prepupae 12hr    3461 white prepupae 24hr    3443 pupae 2d postWPP    3105 pupae 3d postWPP    2150 pupae 4d postWPP    925 adult male 01day    1829 adult male 05day    1463 adult male 30day    1114 adult female 01day    1179 adult female 05day    3715 adult female 30day    2933 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033017 expression level Developmental Stage   Expression Level embryo 00-02hr    4396 embryo 02-04hr    6269 embryo 04-06hr    5573 embryo 06-08hr    3665 embryo 08-10hr    4597 embryo 10-12hr    3094 embryo 12-14hr    5126 embryo 14-16hr    1449 embryo 16-18hr    2494 embryo 18-20hr    1409 embryo 20-22hr    2203 embryo 22-24hr    3673 larva L1    1241 larva L2    1845 larva L3 12hr old    1259 larva L3 puffstage 1-2    1974 larva L3 puffstage 3-6    2270 larva L3 puffstage 7-9    4061 white prepupae new    3772 white prepupae 12hr    3461 white prepupae 24hr    3443 pupae 2d postWPP    3105 pupae 3d postWPP    2150 pupae 4d postWPP    925 adult male 01day    1829 adult male 05day    1463 adult male 30day    1114 adult female 01day    1179 adult female 05day    3715 adult female 30day    2933 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4396) embryo 02-04hr  (6269) embryo 04-06hr  (5573) embryo 06-08hr  (3665) embryo 08-10hr  (4597) embryo 10-12hr  (3094) embryo 12-14hr  (5126) embryo 14-16hr  (1449) embryo 16-18hr  (2494) embryo 18-20hr  (1409) embryo 20-22hr  (2203) embryo 22-24hr  (3673) larva L1  (1241) larva L2  (1845) larva L3 12hr old  (1259) larva L3 puffstage 1-2  (1974) larva L3 puffstage 3-6  (2270) larva L3 puffstage 7-9  (4061) white prepupae new  (3772) white prepupae 12hr  (3461) white prepupae 24hr  (3443) pupae 2d postWPP  (3105) pupae 3d postWPP  (2150) pupae 4d postWPP  (925) adult male 01day  (1829) adult male 05day  (1463) adult male 30day  (1114) adult female 01day  (1179) adult female 05day  (3715) adult female 30day  (2933) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4396) embryo 02-04hr  (6269) embryo 04-06hr  (5573) embryo 06-08hr  (3665) embryo 08-10hr  (4597) embryo 10-12hr  (3094) embryo 12-14hr  (5126) embryo 14-16hr  1449 embryo 16-18hr  (2494) embryo 18-20hr  1409 embryo 20-22hr  2203 embryo 22-24hr  (3673) larva L1    1241 larva L2  1845 larva L3 12hr old    1259 larva L3 puffstage 1-2  1974 larva L3 puffstage 3-6  2270 larva L3 puffstage 7-9  (4061) white prepupae new  (3772) white prepupae 12hr  (3461) white prepupae 24hr  (3443) pupae 2d postWPP  (3105) pupae 3d postWPP  2150 pupae 4d postWPP    925 adult male 01day  1829 adult male 05day  1463 adult male 30day    1114 adult female 01day    1179 adult female 05day  (3715) adult female 30day  (2933) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4396 embryo 02-04hr    6269 embryo 04-06hr    5573 embryo 06-08hr    3665 embryo 08-10hr    4597 embryo 10-12hr    3094 embryo 12-14hr    5126 embryo 14-16hr    1449 embryo 16-18hr    2494 embryo 18-20hr    1409 embryo 20-22hr    2203 embryo 22-24hr    3673 larva L1    1241 larva L2    1845 larva L3 12hr old    1259 larva L3 puffstage 1-2    1974 larva L3 puffstage 3-6    2270 larva L3 puffstage 7-9    4061 white prepupae new    3772 white prepupae 12hr    3461 white prepupae 24hr    3443 pupae 2d postWPP    3105 pupae 3d postWPP    2150 pupae 4d postWPP    925 adult male 01day    1829 adult male 05day    1463 adult male 30day    1114 adult female 01day    1179 adult female 05day    3715 adult female 30day    2933 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4396 embryo 02-04hr    6269 embryo 04-06hr    5573 embryo 06-08hr    3665 embryo 08-10hr    4597 embryo 10-12hr    3094 embryo 12-14hr    5126 embryo 14-16hr    1449 embryo 16-18hr    2494 embryo 18-20hr    1409 embryo 20-22hr    2203 embryo 22-24hr    3673 larva L1    1241 larva L2    1845 larva L3 12hr old    1259 larva L3 puffstage 1-2    1974 larva L3 puffstage 3-6    2270 larva L3 puffstage 7-9    4061 white prepupae new    3772 white prepupae 12hr    3461 white prepupae 24hr    3443 pupae 2d postWPP    3105 pupae 3d postWPP    2150 pupae 4d postWPP    925 adult male 01day    1829 adult male 05day    1463 adult male 30day    1114 adult female 01day    1179 adult female 05day    3715 adult female 30day    2933 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033017    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033017 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult Malpighian tubules, larval fat body, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, larval/adult hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033017 expression level Tissue   Expression Level Larval Central Nervous System    562.15 Larval Midgut    354 Larval Hindgut    478.6 Larval Malpighian Tubules    610.6 Larval Fat Body    628.2 Larval Salivary Gland    494.2 Larval Trachea    483.325 Larval Carcass    382.6 Adult Head    405.5 Adult Eye    476.825 Adult Brain    500.2 Adult Thoracic-Abdominal Ganglion    586.2 Adult Crop    540.8 Adult Midgut    392.2 Adult Hindgut    458.8 Adult Malpighian Tubules    705.6 Adult Fat Body    266.7 Adult Salivary Gland    442.9 Adult Heart    328.825 Adult VirginFemale Spermatheca    508.7 Adult InseminatedFemale Spermatheca    499.4 Adult Ovary    900.8 Adult Testis    410.8 Adult Male Accessory Gland    461.9 Adult Carcass    239.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (562.15) Larval Midgut    354 Larval Hindgut    478.6 Larval Malpighian Tubules  (610.6) Larval Fat Body  (628.2) Larval Salivary Gland    494.2 Larval Trachea    483.325 Larval Carcass    382.6 Adult Head    405.5 Adult Eye    476.825 Adult Brain  500.2 Adult Thoracic-Abdominal Ganglion  (586.2) Adult Crop  (540.8) Adult Midgut    392.2 Adult Hindgut    458.8 Adult Malpighian Tubules  (705.6) Adult Fat Body    266.7 Adult Salivary Gland    442.9 Adult Heart    328.825 Adult VirginFemale Spermatheca  508.7 Adult InseminatedFemale Spermatheca    499.4 Adult Ovary  (900.8) Adult Testis    410.8 Adult Male Accessory Gland    461.9 Adult Carcass    239.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    562.15 Larval Midgut    354 Larval Hindgut    478.6 Larval Malpighian Tubules    610.6 Larval Fat Body    628.2 Larval Salivary Gland    494.2 Larval Trachea    483.325 Larval Carcass    382.6 Adult Head    405.5 Adult Eye    476.825 Adult Brain    500.2 Adult Thoracic-Abdominal Ganglion    586.2 Adult Crop    540.8 Adult Midgut    392.2 Adult Hindgut    458.8 Adult Malpighian Tubules    705.6 Adult Fat Body    266.7 Adult Salivary Gland    442.9 Adult Heart    328.825 Adult VirginFemale Spermatheca    508.7 Adult InseminatedFemale Spermatheca    499.4 Adult Ovary    900.8 Adult Testis    410.8 Adult Male Accessory Gland    461.9 Adult Carcass    239.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    562.15 Larval Midgut    354 Larval Hindgut    478.6 Larval Malpighian Tubules    610.6 Larval Fat Body    628.2 Larval Salivary Gland    494.2 Larval Trachea    483.325 Larval Carcass    382.6 Adult Head    405.5 Adult Eye    476.825 Adult Brain    500.2 Adult Thoracic-Abdominal Ganglion    586.2 Adult Crop    540.8 Adult Midgut    392.2 Adult Hindgut    458.8 Adult Malpighian Tubules    705.6 Adult Fat Body    266.7 Adult Salivary Gland    442.9 Adult Heart    328.825 Adult VirginFemale Spermatheca    508.7 Adult InseminatedFemale Spermatheca    499.4 Adult Ovary    900.8 Adult Testis    410.8 Adult Male Accessory Gland    461.9 Adult Carcass    239.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033017 expression level Tissue   Expression Level Larval Central Nervous System    562.15 Larval Midgut    354 Larval Hindgut    478.6 Larval Malpighian Tubules    610.6 Larval Fat Body    628.2 Larval Salivary Gland    494.2 Larval Trachea    483.325 Larval Carcass    382.6 Adult Head    405.5 Adult Eye    476.825 Adult Brain    500.2 Adult Thoracic-Abdominal Ganglion    586.2 Adult Crop    540.8 Adult Midgut    392.2 Adult Hindgut    458.8 Adult Malpighian Tubules    705.6 Adult Fat Body    266.7 Adult Salivary Gland    442.9 Adult Heart    328.825 Adult VirginFemale Spermatheca    508.7 Adult InseminatedFemale Spermatheca    499.4 Adult Ovary    900.8 Adult Testis    410.8 Adult Male Accessory Gland    461.9 Adult Carcass    239.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  562.15 Larval Midgut    354 Larval Hindgut    478.6 Larval Malpighian Tubules  610.6 Larval Fat Body  628.2 Larval Salivary Gland    494.2 Larval Trachea    483.325 Larval Carcass    382.6 Adult Head    405.5 Adult Eye    476.825 Adult Brain  500.2 Adult Thoracic-Abdominal Ganglion  586.2 Adult Crop  540.8 Adult Midgut    392.2 Adult Hindgut    458.8 Adult Malpighian Tubules  705.6 Adult Fat Body    266.7 Adult Salivary Gland    442.9 Adult Heart    328.825 Adult VirginFemale Spermatheca  508.7 Adult InseminatedFemale Spermatheca    499.4 Adult Ovary  (900.8) Adult Testis    410.8 Adult Male Accessory Gland    461.9 Adult Carcass    239.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    562.15 Larval Midgut    354 Larval Hindgut    478.6 Larval Malpighian Tubules    610.6 Larval Fat Body    628.2 Larval Salivary Gland    494.2 Larval Trachea    483.325 Larval Carcass    382.6 Adult Head    405.5 Adult Eye    476.825 Adult Brain    500.2 Adult Thoracic-Abdominal Ganglion    586.2 Adult Crop    540.8 Adult Midgut    392.2 Adult Hindgut    458.8 Adult Malpighian Tubules    705.6 Adult Fat Body    266.7 Adult Salivary Gland    442.9 Adult Heart    328.825 Adult VirginFemale Spermatheca    508.7 Adult InseminatedFemale Spermatheca    499.4 Adult Ovary    900.8 Adult Testis    410.8 Adult Male Accessory Gland    461.9 Adult Carcass    239.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    562.15 Larval Midgut    354 Larval Hindgut    478.6 Larval Malpighian Tubules    610.6 Larval Fat Body    628.2 Larval Salivary Gland    494.2 Larval Trachea    483.325 Larval Carcass    382.6 Adult Head    405.5 Adult Eye    476.825 Adult Brain    500.2 Adult Thoracic-Abdominal Ganglion    586.2 Adult Crop    540.8 Adult Midgut    392.2 Adult Hindgut    458.8 Adult Malpighian Tubules    705.6 Adult Fat Body    266.7 Adult Salivary Gland    442.9 Adult Heart    328.825 Adult VirginFemale Spermatheca    508.7 Adult InseminatedFemale Spermatheca    499.4 Adult Ovary    900.8 Adult Testis    410.8 Adult Male Accessory Gland    461.9 Adult Carcass    239.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    405.5   NA  Eye    476.825   NA  Brain    500.2   562.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    586.2   NA  Crop    540.8   354  Midgut    392.2   478.6  Hindgut    458.8   610.6  Malpighian Tubules    705.6   628.2  Fat Body    266.7   494.2  Salivary Gland    442.9   NA  Heart    328.825   483.325  Trachea    NA   NA  VirginFemale Spermatheca    508.7   NA  InseminatedFemale Spermatheca    499.4   NA  Ovary    900.8   NA  Testis    410.8   NA  Male Accessory Gland    461.9   382.6  Carcass    239.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033017 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10465-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG10465d00266 Sterility Allele fertile CG10465d00266 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG10465 Class Mutagen Stocks Known lesion CG10465d00266 P-element activity 2 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG10465 Class Mutagen Stocks Known lesion CG10465JF02026 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG10465KK105756 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG10465GD12590 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12590} NA P{KK105756} NA P{TRiP.JF02026} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{XP}CG10465d00266 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
voltage-gated potassium channel activity inferred from electronic annotation with InterPro:IPR003131 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
potassium ion transport inferred from electronic annotation with InterPro:IPR003131 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
voltage-gated potassium channel complex inferred from electronic annotation with InterPro:IPR003131 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG10465 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61401 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033017 DroID - A comprehensive database of gene and protein interactions. • FBgn0033017 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35488
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21506 Dere\GG10865 Dgri\GH23729 Dmoj\GI20668 Dper\GL11047 Dpse\GA10330 Dsec\GM11095 Dsim\GD10363 Dvir\GJ20417 Dwil\GK21368 Dyak\GE11245
Curated drosophilid orthologs	Dpse\GA10330   Dyak\GE11245
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP006173-PA Anopheles gambiae (mosquito) XP_396071.2 Apis mellifera (honey bee) XP_001948307.1 Acyrthosiphon pisum (pea aphid) 123788 Branchiostoma floridae (lancelet) 125524 Branchiostoma floridae (lancelet) XP_001892908.1 Brugia malayi (roundworm nematode) BGIBMGA006562-PA Bombyx mori (silk worm) ENSBTAP00000003492 Bos taurus (bovine) CN13699 Caenorhabditis brenneri (small nematode) CBP10832 Caenorhabditis briggsae (nematode) CE00608 Caenorhabditis elegans (worm) ENSCAFP00000016040 Canis familiaris (dog) ENSCINP00000017700 Ciona intestinalis (sea squirt) JA01947 Caenorhabditis japonica (nematode) ENSCPOP00000020200 Cavia porcellus (guinea pig) RP05121 Caenorhabditis remanei (nematode) ENSCSAVP00000005995 Ciona savignyi (sedentary tunicate) 179715 Capitella spl (polychaete worm) 299808 Daphnia pulex (daphnia) ENSDARP00000010288 Danio rerio (zebra fish) ENSECAP00000017192 Equus caballus (horse) ENSGACP00000012145 Gymnopilus aculeatus (mushroom) ENSGALP00000008235 Gallus gallus (chicken) 165746 Hypsipyla robusta (cedar shoot borer) ENSP00000228495 Homo sapiens (human) ISCW006712-PA Ixodes scapularis (deer tick) 117262 Lottia gigantea (owl limpet) ENSMODP00000024010 Monodelphis domestica (gray opossum) ENSMMUP00000025813 Macaca mulatta (rhesus monkey) ENSMUSP00000001125 Mus musculus (house mouse) 211141 Nematostella vectensis (starlet anemone) ENSORLP00000009396 Oryzias latipes (japanese killifish) PHUM005347-PA Pediculus humanus (human body louse) PP14809 Pristionchus pacificus (nematode) 104545 Physcomitrella patens (moss) ENSPPYP00000005629 Pongo pygmaeus (orangutan) ENSPTRP00000009199 Pan troglodytes (chimpanzee) ENSRNOP00000012245 Rattus norvegicus (norway rat) Smp_194580 Schistosoma mansoni (trematode parasite) XP_001185103.1 Strongylocentrotus purpuratus (purple sea urchin) 4579 Trichoplax adhaerens (metazoa) XP_967447.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018977 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000039043 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000042121 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11222 LH22961 ISCW006712 FBgn0068508 FBgn0223360 FBgn0207557 FBgn0182135 FBgn0166040 JGI_V11_299808 FBgn0070388 FBgn0148657 FBgn0143403 FBgn0131186 FBgn0127622 FBgn0103169 FBgn0098506 BGIBMGA006562 ACYPI008835 GB13359 AGAP006173 AAEL017339 PB25024 PHUM024100 GLEAN_12411
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	19138 w1118; P{XP}CG10465d00266 26002 y1 v1; P{TRiP.JF02026}attP2
Harvard	- P{XP}CG10465d00266
VDRC	v107131 P{KK105756}VIE-260B
Genomic Clones ( 2 )
	BACR02D22 BACR32F22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 75 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE57120
Other clones	DPiM_RE57120 yak-ad_CG10465
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM04707 LD12145 LD17068 LD45748 RE47647 SD25180
Other clones	30303 34649 38933 50117 71449 75414 76492 77341 77730 97230 119880 120503 192430 272941 274612 bs07h10 CK01.22A.F8 CK01.77D.H11 CK01.87C.D8 CK01.87C.H9 CK01.125B.F5 EC36636 EK020356 EK055008 EK060730 EK069148 EK069229 EK096018 EK139645 EK144835 EK156128 EK175961 EK199817 EK206433 EK207323 EK219454 EK299916 EK302047 FGH116F04 RM06769 RM06869 RM06969 RM07069 RM07169 RM07269 RP01102 RP001003404 RP001003806 RP001004082 RP001008776 RP001013417 RP001014932 RP001019617 RP001019701 RP001020822 RP001023495 RP001029285 RP001034799 RP001040284 RP001042249 RP001043580 RP001045901 RP001048600 RP001049244 RP001051450 RP001052650
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033017 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35488
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136321 RefSeq (Proteins) • NP_610165 DDBJ / EMBL / GenBank • AA695879 AAF57336 AAF57336.1 AAL49143 AI945006 AY071521 BI370484 Entrez Gene - A searchable database of RefSeq genes. • 35488 UniProtKB/TrEMBL • Q7JZ62
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Potassium channel, voltage dependent, Kv, tetramerisation (IPR003131) BTB/POZ fold (IPR011333)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61401 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033017 DroID - A comprehensive database of gene and protein interactions. • FBgn0033017 DRSC - Results from RNAi screens. • FBgn0033017 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033017 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10465-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033017 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35488 InParanoid A subset of ortholog calls from InParanoid. • AGAP006173-PA Anopheles gambiae (mosquito) XP_396071.2 Apis mellifera (honey bee) XP_001948307.1 Acyrthosiphon pisum (pea aphid) 123788 Branchiostoma floridae (lancelet) 125524 Branchiostoma floridae (lancelet) XP_001892908.1 Brugia malayi (roundworm nematode) BGIBMGA006562-PA Bombyx mori (silk worm) ENSBTAP00000003492 Bos taurus (bovine) CN13699 Caenorhabditis brenneri (small nematode) CBP10832 Caenorhabditis briggsae (nematode) CE00608 Caenorhabditis elegans (worm) ENSCAFP00000016040 Canis familiaris (dog) ENSCINP00000017700 Ciona intestinalis (sea squirt) JA01947 Caenorhabditis japonica (nematode) ENSCPOP00000020200 Cavia porcellus (guinea pig) RP05121 Caenorhabditis remanei (nematode) ENSCSAVP00000005995 Ciona savignyi (sedentary tunicate) 179715 Capitella spl (polychaete worm) 299808 Daphnia pulex (daphnia) ENSDARP00000010288 Danio rerio (zebra fish) ENSECAP00000017192 Equus caballus (horse) ENSGACP00000012145 Gymnopilus aculeatus (mushroom) ENSGALP00000008235 Gallus gallus (chicken) 165746 Hypsipyla robusta (cedar shoot borer) ENSP00000228495 Homo sapiens (human) ISCW006712-PA Ixodes scapularis (deer tick) 117262 Lottia gigantea (owl limpet) ENSMODP00000024010 Monodelphis domestica (gray opossum) ENSMMUP00000025813 Macaca mulatta (rhesus monkey) ENSMUSP00000001125 Mus musculus (house mouse) 211141 Nematostella vectensis (starlet anemone) ENSORLP00000009396 Oryzias latipes (japanese killifish) PHUM005347-PA Pediculus humanus (human body louse) PP14809 Pristionchus pacificus (nematode) 104545 Physcomitrella patens (moss) ENSPPYP00000005629 Pongo pygmaeus (orangutan) ENSPTRP00000009199 Pan troglodytes (chimpanzee) ENSRNOP00000012245 Rattus norvegicus (norway rat) Smp_194580 Schistosoma mansoni (trematode parasite) XP_001185103.1 Strongylocentrotus purpuratus (purple sea urchin) 4579 Trichoplax adhaerens (metazoa) XP_967447.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018977 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000039043 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000042121 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35488 modMine - Data generated by the modENCODE project. • FBgn0033017 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11222 LH22961 ISCW006712 FBgn0068508 FBgn0223360 FBgn0207557 FBgn0182135 FBgn0166040 JGI_V11_299808 FBgn0070388 FBgn0148657 FBgn0143403 FBgn0131186 FBgn0127622 FBgn0103169 FBgn0098506 BGIBMGA006562 ACYPI008835 GB13359 AGAP006173 AAEL017339 PB25024 PHUM024100 GLEAN_12411
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG10465 (Rossi et al., 2007, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
	FBan0010465
References ( 16 )
Research paper	Rossi et al., 2007, Genetics 175(2): 595--607 Cytogenetic and molecular characterization of heterochromatin gene models in Drosophila melanogaster. [FBrf0192814] Myster et al., 2004, Genetics 166(2): 807--822 Genetic and bioinformatic analysis of 41C and the 2R heterochromatin of Drosophila melanogaster: a window on the heterochromatin-euchromatin junction. [FBrf0174713] Corradini et al., 2003, Chromosoma 112(1): 26--37 FISH analysis of Drosophila melanogaster heterochromatin using BACs and P elements. [FBrf0160459]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 1.15.2009, Initial TRiP stock collection. Initial TRiP stock collection. [FBrf0206489] Drosophila Heterochromatin Genome Project, 2006, Release 5.1 of the annotated Drosophila melanogaster heterochromatin. Release 5.1 of the annotated Drosophila melanogaster heterochromatin. [FBrf0188763] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]