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Gene Dmel\dream

General Information
Symbol	Dmel\dream	Species	D. melanogaster
Name	dream	Annotation symbol	CG7863
Feature type	protein_coding_gene	FlyBase ID	FBgn0033051
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	strica, Strica/Dream
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	42A8-42A8	Sequence location	2R:1,907,816..1,910,649 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dream is referred to in FlyBase by the symbol Dmel\dream (CG7863, FBgn0033051). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cysteine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process: salivary gland histolysis; programmed cell death; nurse cell apoptotic process; positive regulation of compound eye retinal cell programmed cell death. 11 alleles are reported. The phenotypes of these alleles are annotated with: eye; egg chamber. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Peptidase C14, ICE, catalytic subunit p20; Peptidase C14, caspase catalytic; Peptidase C14, caspase non-catalytic subunit p10; Peptidase C14, caspase precursor p45; Peptidase C14, caspase precursor p45, core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body, larval salivary gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632790_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dream. Gene sequence location is 2R:1907816..1910649.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42A8-42A8   Limits computationally determined from genome sequence between P{PZ}l(2)0985109851&P{lacW}Src42Ak10108 and P{lacW}l(2)k09848k09848&P{EP}EP407
Experimentally Determined Cytological Location
Cytogenetic map Notes References 42A3-42A16     (Doumanis, 2000.3.8)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dream for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dream-RA FBtr0086028  NM_136349   2163   527 dream-RB FBtr0335289  NM_001273789   2720   527
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dream-PA   FBpp0085364   57.4   527   10.48     NP_610193   AAF57292 dream-PB   FBpp0307275   57.4   527   10.48     NP_001260718   AGB93252
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C14, ICE, catalytic subunit p20 (IPR001309) Peptidase C14, caspase non-catalytic subunit p10 (IPR002138) Peptidase C14, caspase precursor p45 (IPR002398) Peptidase C14, caspase catalytic (IPR011600) Peptidase C14, caspase precursor p45, core (IPR015917)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA438962   AE013599 AAF57292   AF242735 AAF78902   AF275814 AAF78092   AE013599 AGB93252   AI295546   AW942269   BI371552   BI484291   BI577925   BI632260   BI638496   BT024233   CK660449   CO154783   CO154809   CO303777   CO305371   CO311367   CO323173   CZ467754   DN153937   EC051705   EC052732   EC054725   EC056029   EC063173   EC076305   EC086946   EC202344   EC262860   GH748000   GH748078   GH748194   GH749780   GH749844   GH750911   GH751040   GH752422   GH752802   GH753705   GH753873   GH754130   GH755590   GH755921   GH756530   GH757853   GH758245   GH759088   GH759611   GH760814   GH761067   GH761392   GH770470   GH771368   GH772091   GH772842   GH774231   GH774894   GH775190   GH775303   GH778206   GH782086   GH782431   GH782940   GH784060   GH784409   GH786138   GH786199   GH786215   GH786380   GH787097   GH787271   GH787528   GH788519   GH789511   GH790175   GH790658   GH791085   GH791895   GH792144   GH794294   GH795274   GH795517   GH795625   GH795696   GH796234   GH796824   GH797436   GH797510   GH798299   GH799056   GH801111   GH802794   GH803715   GH803753   GH804574   GH805143   GH805409   GH805447   GH805565   GH805803   GH806105   GH806187   GH806353   GH806847   GH806903   GH807390   GH809551   GH810806   GH810946   GH811062   GH812497   GH812499   GH812765   GH814136   GH815307   GH815462   GH817128   GH821130   GH822559   GH828275   GH828527   GH830526   GH830707   GH831487   GH832329   GH833618   GH833887   GH835330   GH835384   GH835560   GH836071   GH837026   GH837253   GH838070   GH838443   GH839551   GH839566   GH840030   GH840411   GH840441   GH843117   GH844810   GH845196   GH846104   GH849995   GH850223   GH851723   GH852262   GH852453   GH853160   GH853616   GH853801   GH853991   GH854255   GH854626   GH856046   GH856234   GH856453   GH856871   GH856950   GH857987   GH858709   GH858959   GH859011   GH859684   GH862040   GH864421   GH866076   GH866561   GH866803   GH867002   GH867907   GH869069   GH871043   GH871124   GH872431   GH876162   GH877439   GH877888   GH879812   GH880217   GH880302   GH881095   GH881406   GH881593   GH881787   GH883366   GH883522   GH883622   GH883687   GH884097   GH884658   GH884697   GH884786   GH885427   GH886121   GH886373   GH889550   GH890614   GH890758   GH891116   GH892454   GH893231   GH893620   GH896413   GH896708   GH897752   GH898180   GH898587   GH899476   GH900244   GH900261   GH900765   GH902358   GH903019   GH903112   GH903942   GH904408   GH905299   GH906180   GH906522   GH907319   GH908174   GH908442   GH908646   GH909838   GH910321   GH913407   GH913554   GH913611   GH914419   GH916068   GH916450   GH917281   GH918407   GH919406   GH921350   GH924899   GH925333   GH925585   GH925860   GH927112   GH927278   GH927356   GH927861   GH927887   GH928423   GH928704   GH930451   GH930484   GH930664   GH931228   GH931612   GH932266   GH933222   GH933515   GH933843   GH934712   GH937000
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KHK9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 1 -- 4   organism | ubiquitous   (Doumanis et al., 2001) Comment:maternally contributed embryonic stage 5 -- 17   organism | restricted   (Doumanis et al., 2001) third instar larval stage   embryonic/larval midgut   (Doumanis et al., 2001) embryonic/larval proventriculus   (Doumanis et al., 2001) embryonic/larval salivary gland   (Doumanis et al., 2001) adult stage | female & oogenesis stage S10   nurse cell   • cytoplasm (Doumanis et al., 2001) adult stage | femaleoogenesis stage S11 -- S12   oocyte   • cytoplasm (Doumanis et al., 2001) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Doumanis et al., 2001) pupal stage   salivary gland   (Lee et al., 2003) RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Doumanis et al., 2001) Comment:expression is higher in pupae and adults
Additional Descriptive Data
	The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue. (Lee et al., 2003)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Doumanis et al., 2001)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body, larval salivary gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    17.5 Larval Midgut    309.7 Larval Hindgut    124.6 Larval Malpighian Tubules    299.6 Larval Fat Body    170.1 Larval Salivary Gland    251.1 Larval Trachea    94.2 Larval Carcass    102.475 Adult Head    11.2 Adult Eye    1.95 Adult Brain    6 Adult Thoracic-Abdominal Ganglion    5.3 Adult Crop    3.8 Adult Midgut    212.7 Adult Hindgut    46.9 Adult Malpighian Tubules    183.2 Adult Fat Body    15.5 Adult Salivary Gland    6.6 Adult Heart    18.525 Adult VirginFemale Spermatheca    24.4 Adult InseminatedFemale Spermatheca    35.3 Adult Ovary    79.5 Adult Testis    8.8 Adult Male Accessory Gland    42.8 Adult Carcass    8.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    17.5 Larval Midgut    309.7 Larval Hindgut    124.6 Larval Malpighian Tubules    299.6 Larval Fat Body    170.1 Larval Salivary Gland    251.1 Larval Trachea    94.2 Larval Carcass    102.475 Adult Head    11.2 Adult Eye    1.95 Adult Brain    6 Adult Thoracic-Abdominal Ganglion    5.3 Adult Crop    3.8 Adult Midgut    212.7 Adult Hindgut    46.9 Adult Malpighian Tubules    183.2 Adult Fat Body    15.5 Adult Salivary Gland    6.6 Adult Heart    18.525 Adult VirginFemale Spermatheca    24.4 Adult InseminatedFemale Spermatheca    35.3 Adult Ovary    79.5 Adult Testis    8.8 Adult Male Accessory Gland    42.8 Adult Carcass    8.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    17.5 Larval Midgut    309.7 Larval Hindgut    124.6 Larval Malpighian Tubules    299.6 Larval Fat Body    170.1 Larval Salivary Gland    251.1 Larval Trachea    94.2 Larval Carcass    102.475 Adult Head    11.2 Adult Eye    1.95 Adult Brain    6 Adult Thoracic-Abdominal Ganglion    5.3 Adult Crop    3.8 Adult Midgut    212.7 Adult Hindgut    46.9 Adult Malpighian Tubules    183.2 Adult Fat Body    15.5 Adult Salivary Gland    6.6 Adult Heart    18.525 Adult VirginFemale Spermatheca    24.4 Adult InseminatedFemale Spermatheca    35.3 Adult Ovary    79.5 Adult Testis    8.8 Adult Male Accessory Gland    42.8 Adult Carcass    8.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    17.5 Larval Midgut    309.7 Larval Hindgut    124.6 Larval Malpighian Tubules    299.6 Larval Fat Body    170.1 Larval Salivary Gland    251.1 Larval Trachea    94.2 Larval Carcass    102.475 Adult Head    11.2 Adult Eye    1.95 Adult Brain    6 Adult Thoracic-Abdominal Ganglion    5.3 Adult Crop    3.8 Adult Midgut    212.7 Adult Hindgut    46.9 Adult Malpighian Tubules    183.2 Adult Fat Body    15.5 Adult Salivary Gland    6.6 Adult Heart    18.525 Adult VirginFemale Spermatheca    24.4 Adult InseminatedFemale Spermatheca    35.3 Adult Ovary    79.5 Adult Testis    8.8 Adult Male Accessory Gland    42.8 Adult Carcass    8.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    17.5 Larval Midgut    309.7 Larval Hindgut    124.6 Larval Malpighian Tubules    299.6 Larval Fat Body    170.1 Larval Salivary Gland    251.1 Larval Trachea    94.2 Larval Carcass    102.475 Adult Head    11.2 Adult Eye    1.95 Adult Brain    6 Adult Thoracic-Abdominal Ganglion    5.3 Adult Crop    3.8 Adult Midgut    212.7 Adult Hindgut    46.9 Adult Malpighian Tubules    183.2 Adult Fat Body    15.5 Adult Salivary Gland    6.6 Adult Heart    18.525 Adult VirginFemale Spermatheca    24.4 Adult InseminatedFemale Spermatheca    35.3 Adult Ovary    79.5 Adult Testis    8.8 Adult Male Accessory Gland    42.8 Adult Carcass    8.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    17.5 Larval Midgut    309.7 Larval Hindgut    124.6 Larval Malpighian Tubules    299.6 Larval Fat Body    170.1 Larval Salivary Gland    251.1 Larval Trachea    94.2 Larval Carcass    102.475 Adult Head    11.2 Adult Eye    1.95 Adult Brain    6 Adult Thoracic-Abdominal Ganglion    5.3 Adult Crop    3.8 Adult Midgut    212.7 Adult Hindgut    46.9 Adult Malpighian Tubules    183.2 Adult Fat Body    15.5 Adult Salivary Gland    6.6 Adult Heart    18.525 Adult VirginFemale Spermatheca    24.4 Adult InseminatedFemale Spermatheca    35.3 Adult Ovary    79.5 Adult Testis    8.8 Adult Male Accessory Gland    42.8 Adult Carcass    8.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    17.5 Larval Midgut    309.7 Larval Hindgut    124.6 Larval Malpighian Tubules    299.6 Larval Fat Body    170.1 Larval Salivary Gland    251.1 Larval Trachea    94.2 Larval Carcass    102.475 Adult Head    11.2 Adult Eye    1.95 Adult Brain    6 Adult Thoracic-Abdominal Ganglion    5.3 Adult Crop    3.8 Adult Midgut    212.7 Adult Hindgut    46.9 Adult Malpighian Tubules    183.2 Adult Fat Body    15.5 Adult Salivary Gland    6.6 Adult Heart    18.525 Adult VirginFemale Spermatheca    24.4 Adult InseminatedFemale Spermatheca    35.3 Adult Ovary    79.5 Adult Testis    8.8 Adult Male Accessory Gland    42.8 Adult Carcass    8.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    17.5 Larval Midgut    309.7 Larval Hindgut    124.6 Larval Malpighian Tubules    299.6 Larval Fat Body    170.1 Larval Salivary Gland    251.1 Larval Trachea    94.2 Larval Carcass    102.475 Adult Head    11.2 Adult Eye    1.95 Adult Brain    6 Adult Thoracic-Abdominal Ganglion    5.3 Adult Crop    3.8 Adult Midgut    212.7 Adult Hindgut    46.9 Adult Malpighian Tubules    183.2 Adult Fat Body    15.5 Adult Salivary Gland    6.6 Adult Heart    18.525 Adult VirginFemale Spermatheca    24.4 Adult InseminatedFemale Spermatheca    35.3 Adult Ovary    79.5 Adult Testis    8.8 Adult Male Accessory Gland    42.8 Adult Carcass    8.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    1.95   NA  Brain    6   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    5.3   NA  Crop    3.8   309.7  Midgut    212.7   124.6  Hindgut    46.9   299.6  Malpighian Tubules    183.2   170.1  Fat Body    no informative data   251.1  Salivary Gland    6.6   NA  Heart    no informative data   94.2  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    79.5   NA  Testis    8.8   NA  Male Accessory Gland    42.8   102.475  Carcass    8.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    4 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    42 salivary gland, white prepupae    160 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    22 digestive system, 4-day adult    20 digestive system, 20-day adult    23 fat body, larvae L3 wandering    11 fat body, white prepupae    37 fat body, pupae P8    14 carcass, larvae L3 wandering    11 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    5 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    4 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering  (42) salivary gland, white prepupae  (160) digestive system, larvae L3 wandering  (60) digestive system, 1-day adult    22 digestive system, 4-day adult    20 digestive system, 20-day adult    23 fat body, larvae L3 wandering    11 fat body, white prepupae  (37) fat body, pupae P8    14 carcass, larvae L3 wandering    11 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    5 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    4 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    42 salivary gland, white prepupae  (160) digestive system, larvae L3 wandering    60 digestive system, 1-day adult    22 digestive system, 4-day adult    20 digestive system, 20-day adult    23 fat body, larvae L3 wandering    11 fat body, white prepupae    37 fat body, pupae P8    14 carcass, larvae L3 wandering    11 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    5 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    4 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    42 salivary gland, white prepupae    160 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    22 digestive system, 4-day adult    20 digestive system, 20-day adult    23 fat body, larvae L3 wandering    11 fat body, white prepupae    37 fat body, pupae P8    14 carcass, larvae L3 wandering    11 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    5 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    4 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    42 salivary gland, white prepupae    160 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    22 digestive system, 4-day adult    20 digestive system, 20-day adult    23 fat body, larvae L3 wandering    11 fat body, white prepupae    37 fat body, pupae P8    14 carcass, larvae L3 wandering    11 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    5 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    4 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering  (42) salivary gland, white prepupae  (160) digestive system, larvae L3 wandering  (60) digestive system, 1-day adult    22 digestive system, 4-day adult    20 digestive system, 20-day adult    23 fat body, larvae L3 wandering    11 fat body, white prepupae  (37) fat body, pupae P8    14 carcass, larvae L3 wandering    11 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    5 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    4 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    42 salivary gland, white prepupae  (160) digestive system, larvae L3 wandering    60 digestive system, 1-day adult    22 digestive system, 4-day adult    20 digestive system, 20-day adult    23 fat body, larvae L3 wandering    11 fat body, white prepupae    37 fat body, pupae P8    14 carcass, larvae L3 wandering    11 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    5 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    4 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    42 salivary gland, white prepupae    160 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    22 digestive system, 4-day adult    20 digestive system, 20-day adult    23 fat body, larvae L3 wandering    11 fat body, white prepupae    37 fat body, pupae P8    14 carcass, larvae L3 wandering    11 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    5 ovary, mated 4-day female    7 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    14 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    3 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    14 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    3 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    14 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    3 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    14 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    3 adult female 05day    3 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    14 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    3 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    14 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    3 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    14 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    3 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    4 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    14 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    3 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    124 Schneider line 2 Sg4    38 embryonic 1182-4H    59 embryonic GM2    75 embryonic Kc167    37 embryonic S1    41 embryonic S3    77 leg disc CME L1    59 wing disc CME-W2    31 wing disc ML-DmD8    16 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    27 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    52 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    43 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (124) Schneider line 2 Sg4  (38) embryonic 1182-4H  (59) embryonic GM2  (75) embryonic Kc167  (37) embryonic S1  (41) embryonic S3  (77) leg disc CME L1  (59) wing disc CME-W2  (31) wing disc ML-DmD8    16 wing disc ML-DmD9  (32) wing disc ML-DmD16-c3  (44) wing disc ML-DmD21  (27) wing disc ML-DmD32  (45) haltere disc ML-DmD17-c3  (52) eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1  (37) CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2  (43) ovary fGS/OSS    2 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (124) Schneider line 2 Sg4    38 embryonic 1182-4H    59 embryonic GM2    75 embryonic Kc167    37 embryonic S1    41 embryonic S3    77 leg disc CME L1    59 wing disc CME-W2    31 wing disc ML-DmD8    16 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    27 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    52 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    43 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    124 Schneider line 2 Sg4    38 embryonic 1182-4H    59 embryonic GM2    75 embryonic Kc167    37 embryonic S1    41 embryonic S3    77 leg disc CME L1    59 wing disc CME-W2    31 wing disc ML-DmD8    16 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    27 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    52 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    43 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    124 Schneider line 2 Sg4    38 embryonic 1182-4H    59 embryonic GM2    75 embryonic Kc167    37 embryonic S1    41 embryonic S3    77 leg disc CME L1    59 wing disc CME-W2    31 wing disc ML-DmD8    16 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    27 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    52 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    43 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (124) Schneider line 2 Sg4  (38) embryonic 1182-4H  (59) embryonic GM2  (75) embryonic Kc167  (37) embryonic S1  (41) embryonic S3  (77) leg disc CME L1  (59) wing disc CME-W2  31 wing disc ML-DmD8    16 wing disc ML-DmD9  32 wing disc ML-DmD16-c3  (44) wing disc ML-DmD21  27 wing disc ML-DmD32  (45) haltere disc ML-DmD17-c3  (52) eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1  (37) CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2  (43) ovary fGS/OSS    2 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  124 Schneider line 2 Sg4    38 embryonic 1182-4H    59 embryonic GM2    75 embryonic Kc167    37 embryonic S1    41 embryonic S3    77 leg disc CME L1    59 wing disc CME-W2    31 wing disc ML-DmD8    16 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    27 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    52 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    43 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    124 Schneider line 2 Sg4    38 embryonic 1182-4H    59 embryonic GM2    75 embryonic Kc167    37 embryonic S1    41 embryonic S3    77 leg disc CME L1    59 wing disc CME-W2    31 wing disc ML-DmD8    16 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    27 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    52 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    43 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    18 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    18 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    18 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    18 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    18 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    18 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    18 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    18 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_25 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • LD13366 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033051 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7863-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable dream1 dream2 dream3 dream4 viable, with Scer\GAL4pnr-MD237 dreamGD12308 Sterility Allele fertile dream1 dream2 dream3 dream4 Other Phenotypes Allele cell death defective dream2 dream3 cell death defective (with Df(2R)nap9) dream2 cell death defective (with dream2) dream3 cell death defective (with dream3) dream2 visible dreamGMR.PX Phenotype manifest in Allele egg chamber dream2 dream3 egg chamber (with Df(2R)nap9) dream2 egg chamber (with dream2) dream3 egg chamber (with dream3) dream2 eye dreamGMR.PX inter-ommatidial precursor cell | pupal stage P7 | supernumerary, with Scer\GAL4GMR.PF dreamdsRNA.Scer\UAS.cLa salivary gland | pupal stage, with Scer\GAL434B dreamdsRNA.Scer\UAS.cLa
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of dream Class Mutagen Stocks Known lesion dreame00821 piggyBac transposase 2 -- dreamd06491 hypomorphic allele - molecular evidence 1 -- dream4 amorphic allele - molecular evidence Delta2-3 0 Yes dream1 Delta2-3 0 Yes dream2 hypomorphic allele - molecular evidence Delta2-3 0 Yes dream3 hypomorphic allele - molecular evidence Delta2-3 0 Yes dreamc02188 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dream Class Mutagen Stocks Known lesion dreamGD12308 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dreamdsRNA.Scer\UAS.cLa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes dreamGMR.PX in vitro construct - regulatory fusion 0 Yes dreamNIG.7863R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7085 (Ryder, 2004.4.26) Df(2R)SCAPΔ910 (Matthews et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12308} NA P{NIG.7863R} NA characterization construct P{GMR-Strica.X} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}dreamc02188 NA PBac{RB}dreame00821 NA insertion of mobile activating element P{XP}dreamd06491 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
nurse cell apoptotic process inferred from genetic interaction with Nc (Baum et al., 2007) positive regulation of compound eye retinal cell programmed cell death inferred from mutant phenotype (Leulier et al., 2006) programmed cell death inferred from direct assay (Lee et al., 2011) salivary gland histolysis inferred from mutant phenotype (Leulier et al., 2006)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Doumanis et al., 2001)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase activity inferred from sequence or structural similarity with mouse Casp7 (FlyBase, 1992-) non-traceable author statement (Doumanis, 2000.3.8, Yoo, 2000.6.6, Gorski and Marra, 2002) traceable author statement (Kumar and Doumanis, 2000)
Biological Process
CV term Evidence References
programmed cell death traceable author statement (Richardson and Kumar, 2002) proteolysis inferred from electronic annotation with InterPro:IPR001309, InterPro:IPR002138, InterPro:IPR002398, InterPro:IPR011600 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
dream - B-H1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Bx42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG10086 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG10103 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG10660 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG10958 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG11191 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG11723 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG14109 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG14141 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG14262 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG14556 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG14718 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG14826 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG1486 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG15484 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG18619 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG31637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG4415 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG4951 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG5043 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG5343 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG5805 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG6123 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG6652 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG6852 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG7239 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG7669 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG7686 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG8010 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG8368 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CG8478 experimental knowledge based (Guruharsha et al., 2011) dream - CG8765 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - CanA1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Cdc23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Chi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Cp110 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Dgk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Drep-1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) dream - Ect4 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) dream - GABPI anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - GstE14 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Kr-h1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Lst8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Oamb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Orct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Pdk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Pitslre anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Rab10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Rad9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - RagC-D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - RluA-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - SCAR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Socs44A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Tak1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - Tsp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - al anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - atms anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - dimm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - eya anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - fd59A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - l(2)gl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - l(3)02640 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - lwr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - mael anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - msn experimental knowledge based (Guruharsha et al., 2011) dream - p-cup anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - pigeon anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - rumi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - sktl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - stv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - thoc7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - vig anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dream - yellow-f2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dream allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0033051
Orthologs
OrthoDB Orthologs (21) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PZJSW Dipteran inclusive ortholog search EOG6KWK2S Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6PZJSW)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\dream     Drosophila simulans   Dsim\GD10341 Y   Drosophila sechellia   Dsec\GM16490 Y   Drosophila erecta   Dere\GG10839 Y   Drosophila yakuba   Dyak\GE19433 Y   Drosophila ananassae   Dana\GF13826 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20641 Y   Drosophila persimilis   Dper\GL17786 Y   Drosophila willistoni   Dwil\GK17914 Y   Drosophila virilis   Dvir\GJ20868 Y   Drosophila mojavensis   Dmoj\GI21266 Y   Drosophila grimshawi   Dgri\GH22881 Y
Orthologs in non-Drosophila Dipterans (EOG6KWK2S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005963 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL017498 Y Aedes aegypti Yellow fever mosquito  Aaeg\CASPS17 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005956 Y Anopheles gambiae Malaria mosquito  Agam\CASPS12 Y Anopheles gambiae Malaria mosquito  Agam\CASPS9 Y Anopheles gambiae Malaria mosquito  Agam\CASPS13 Y Anopheles gambiae Malaria mosquito  Agam\CASPS10 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012580 Y
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10341 Drosophila sechellia Dsec\GM16490 Drosophila erecta Dere\GG10839 Drosophila yakuba Dyak\GE19433 Drosophila ananassae Dana\GF13826 Drosophila pseudoobscura pseudoobscura Dpse\GA20641 Drosophila persimilis Dper\GL17786 Drosophila willistoni Dwil\GK17914 Drosophila virilis Dvir\GJ20868 Drosophila mojavensis Dmoj\GI21266 Drosophila grimshawi Dgri\GH22881
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	17888 w1118; PBac{RB}dreame00821/CyO
Harvard	- P{XP}dreamd06491 - PBac{RB}dreame00821
VDRC	v22594 w1118; P{GD12308}v22594 v22593 w1118; P{GD12308}v22593/TM3
Genomic Clones ( 2 )
	BACR13P06 BACR39E09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 253 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD13366
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP09213 LP19051 RE58467 RE67370 RE71695 SD20794 SD25984
Other clones	64083 77412 102974 524143 EC051705 EC052732 EC054725 EC056029 EK138703 EK189860 EK224311 EK242733 EK248401 EN04804 EN04839 RP003000176 RP003009308 RP003011810 RP003012806 RP003013219 RP003014062 RP003014301 RP003014484 RP003016076 RP003018563 RP003019556 RP003021775 RP003024018 RP003024801 RP003026329 RP003029070 RP003029577 RP003030826 RP003032935 RP003040210 RP003040965 RP003042120 RP003042333 RP003049589 RP003052437 RP003052901 RP003053632 RP003054082 RP003054530 RP003055405 RP003055680 RP003057858 RP003063891 RP003071953 RP003072714 RP003075968 RP003076856 RP003077814 RP003079104 RP003079789 RP003082908 RP003083014 RP003083969 RP003088825 RP003090145 RP003094966 RP003095364 RP003097420 RP003097444 RP003097843 RP003101791 RP003102553 RP003111921 RP003116398 RP003118456 RP003119608 RP003119625 RP003122331 RP003124122 RP003126352 RP003126593 RP003129284 RP003135852 RP003136955 RP003140680 RP003140949 RP003141553 RP003148269 RP003150235 RP003150709 RP003151149 RP003152527 RP003155683 RP003156575 RP003166822 RP003169486 RP003169895 RP003171521 RP003182043 RP003184578 RP003184685 RP003186689 RP003193389 RP003210748 RP003211330 RP003212836 RP003212970 RP003216873 RP003220051 RP003221641 RP003222630 RP003223032 RP003236711 RP003238918 RP003239025 RP003242800 RP003243373 RP003251011 RP003252949 RP003254187 RP003258055 RP003260247 RP003268394 RP003275089 RP003277615 RP003283751 RP003287200 RP003291730 RP003294465 RP003309313 RP003312701 RP003318797 RP003325702 RP003330954 RP003333281 RP003339314 RP003350642 RP003357050 RP003359603 RP003365581 RP003369700 RP003370073 RP003370154 RP003373716 RP003375218 RP003376380 RP003376835 RP003377885 RP003381739 RP003387625 RP003393952 RP003397411 RP003403120 RP003404428 RP003405030 RP003405563 RP003405654 RP003405992 RP003406421 RP003406591 RP003409697 RP003412458 RP003416447 RP003416482 RP003418008 RP003419538 RP003423235 RP003423361 RP003423362 RP003424414 RP003430617 RP003433085 RP003434883 RP003438102 RP003439548 RP003443721 RP003450010 RP003450563 RP003453421 RP003458579 RP003460157 RP003460162 RP003460434 RP003460521 RP003465426 RP003466754 RP003467739 RP003469134 RP003469349 RP003474433 RP003475648 RP003476953 RP003479715 RP003481209 RP003481320 RP003482509 RP003484578 RP003485390 RP003488022 RP003488361 RP003490240 RP003490796 RP003497132 RP003497890 RP003501465 RP003505438 RP003506328 RP003506350 RP003508917 RP003509292 RP003512960 RP003517045 RP003525606 RP003529341 RP003530136 RP003536024 RP003537557 RP003551047 RP003560117 RP003561276 RP003562915 RP003566583 RP003569273 RP003570143 RP003572869 RP003574283 RP003578974 RP003579731 RP003584821 RP003585515 RP003589344 RP003595982 RP003601642 RP003603678 RP003604973 RP003605027 RP003605910 RP003611058 RP003613107 RP003616883 RP003622089 RP003651509 RP003657830 RP003658030 RP003668619 RP003674914 RP003676901 RP003679892 RP003682084 RP003682839
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033051 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35528
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dream CG7863 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of dream CG7863 was sequence comparison (date:000622). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136349 NM_001273789 RefSeq (Proteins) • NP_610193 NP_001260718 DDBJ / EMBL / GenBank • AA438962 AAF57292 AAF78092 AAF78902 AF242735 AF275814 AGB93252 AW942269 CZ467754 Entrez Gene - A searchable database of RefSeq genes. • 35528 UniProtKB/TrEMBL • Q7KHK9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C14, ICE, catalytic subunit p20 (IPR001309) Peptidase C14, caspase non-catalytic subunit p10 (IPR002138) Peptidase C14, caspase precursor p45 (IPR002398) Peptidase C14, caspase catalytic (IPR011600) Peptidase C14, caspase precursor p45, core (IPR015917) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD13366
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0033051 DRSC - Results from RNAi screens. • FBgn0033051 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033051 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7863-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033051 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35528 modMine - Data generated by the modENCODE project. • FBgn0033051
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG7863 (Lee et al., 2003, Boutros et al., 2002, ) dream (Ranz et al., 2004, Matthews et al., 2010, Terashima and Bownes, 2005, Japanese National Institute of Genetics, 2012.5.21) Dream (Amarneh et al., 2009) DREAM (Fan and Bergmann, 2010) Dream/Strica (Huh et al., 2007) strica (Baum et al., 2007, Kumar and Cakouros, 2004, Doumanis, 2000.3.8, McCall et al., 2007, Doumanis et al., 2001, Khammari et al., 2011, Leulier et al., 2006, Denton et al., 2009, Lee et al., 2011, Florentin and Arama, 2012) STRICA (Harvey et al., 2001) Strica (Chen et al., 2012, Kuranaga and Miura, 2007, Copeland et al., 2007) Strica/Dream (Richardson and Kumar, 2002, Gorski and Marra, 2002, Leulier et al., 2006, Martin et al., 2007) STRICA/DREAM (Kumar and Doumanis, 2000)
Name Synonym	dream (Terashima and Bownes, 2005) Ser/Thr-RIch-CAspase (Doumanis et al., 2001) Strica (Baehrecke, 2003, Xu et al., 2003, Xie and Birchler, 2007, Kornbluth and White, 2005) strica (Xie and Birchler, 2008)
Secondary FlyBase IDs
References ( 55 )
Generate a list of	All references relating to this gene ( 55 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 5 ) Review  ( 7 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Chen et al., 2012, Cell Death Differ. 19(10): 1655--1663 Effectors of alcohol-induced cell killing in Drosophila. [FBrf0219410] Florentin and Arama, 2012, J. Cell Biol. 196(4): 513--527 Caspase levels and execution efficiencies determine the apoptotic potential of the cell. [FBrf0217486] Khammari et al., 2011, Cell Death Differ. 18(5): 793--805 Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1. [FBrf0213412] Lee et al., 2011, J. Comp. Neurol. 519(1): 34--48 Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. [FBrf0212368] Xie et al., 2011, Genetics 188(4): 823--834 Inhibition of RNA interference and modulation of transposable element expression by cell death in Drosophila. [FBrf0214636] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...