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Gene Dmel\CG14591

General Information
Symbol	Dmel\CG14591	Species	D. melanogaster
Name		Annotation symbol	CG14591
Feature type	protein_coding_gene	FlyBase ID	FBgn0033054
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	42A8-42A8	Sequence location	2R:1,924,063..1,928,087 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG14591 (FBgn0033054). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640767_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of CG14591. Gene sequence location is 2R:1924063..1928087.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA04868 BKN21595
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42A8-42A8   Limits computationally determined from genome sequence between P{PZ}l(2)0985109851&P{lacW}Src42Ak10108 and P{lacW}l(2)k09848k09848&P{EP}EP407
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG14591 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG14591-RA FBtr0086025  NM_136352   1732   332 CG14591-RB FBtr0086026  NM_165456   1771   332 CG14591-RC FBtr0302827  NM_001201935   1627   332 CG14591-RD FBtr0302828  NM_001201936   1578   332
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG14591-PA   FBpp0085361   37.6   332   6.88     NP_610196   AAF57289 CG14591-PB   FBpp0085362   37.6   332   6.88     NP_724447   AAM68341 CG14591-PC   FBpp0291967   37.6   332   6.88     NP_001188864   ADV37113 CG14591-PD   FBpp0291968   37.6   332   6.88     NP_001188865   ADV37114
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57289   AE013599 AAM68341   AE013599 ADV37113   AE013599 ADV37114   AI533722   AY075538 AAL68345   BI573388   BI573389   BI575070   BI581652   BI584352   BI585627   BI617378   BI618922   BT001831 AAN71586   CO178138   CO190093   CO274494   CO277995   CO283345   CO287284   CO344005   DN154104   EC069104   EC073482   EC195756   EC200145   EC203298   EC224926   EC227189   EC234617   EC238828   EC243965   EC244416   EC257427   GH944759   GH969345   GH970509   GH971591   GH980205
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JRB2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033054    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033054 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033054 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    18 embryo 04-06hr    33 embryo 06-08hr    28 embryo 08-10hr    39 embryo 10-12hr    141 embryo 12-14hr    189 embryo 14-16hr    413 embryo 16-18hr    668 embryo 18-20hr    624 embryo 20-22hr    657 embryo 22-24hr    700 larva L1    839 larva L2    256 larva L3 12hr old    73 larva L3 puffstage 1-2    125 larva L3 puffstage 3-6    219 larva L3 puffstage 7-9    327 white prepupae new    359 white prepupae 12hr    540 white prepupae 24hr    508 pupae 2d postWPP    579 pupae 3d postWPP    1627 pupae 4d postWPP    4129 adult male 01day    1999 adult male 05day    2081 adult male 30day    1984 adult female 01day    1017 adult female 05day    297 adult female 30day    232 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    18 embryo 04-06hr    33 embryo 06-08hr    28 embryo 08-10hr    39 embryo 10-12hr  (141) embryo 12-14hr  (189) embryo 14-16hr  (413) embryo 16-18hr  (668) embryo 18-20hr  (624) embryo 20-22hr  (657) embryo 22-24hr  (700) larva L1  (839) larva L2  (256) larva L3 12hr old    73 larva L3 puffstage 1-2  (125) larva L3 puffstage 3-6  (219) larva L3 puffstage 7-9  (327) white prepupae new  (359) white prepupae 12hr  (540) white prepupae 24hr  (508) pupae 2d postWPP  (579) pupae 3d postWPP  (1627) pupae 4d postWPP  (4129) adult male 01day  (1999) adult male 05day  (2081) adult male 30day  (1984) adult female 01day  (1017) adult female 05day  (297) adult female 30day  (232) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    18 embryo 04-06hr    33 embryo 06-08hr    28 embryo 08-10hr    39 embryo 10-12hr    141 embryo 12-14hr    189 embryo 14-16hr    413 embryo 16-18hr    668 embryo 18-20hr    624 embryo 20-22hr    657 embryo 22-24hr    700 larva L1    839 larva L2    256 larva L3 12hr old    73 larva L3 puffstage 1-2    125 larva L3 puffstage 3-6    219 larva L3 puffstage 7-9    327 white prepupae new    359 white prepupae 12hr    540 white prepupae 24hr    508 pupae 2d postWPP    579 pupae 3d postWPP  (1627) pupae 4d postWPP  (4129) adult male 01day  (1999) adult male 05day  (2081) adult male 30day  (1984) adult female 01day    1017 adult female 05day    297 adult female 30day    232 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    18 embryo 04-06hr    33 embryo 06-08hr    28 embryo 08-10hr    39 embryo 10-12hr    141 embryo 12-14hr    189 embryo 14-16hr    413 embryo 16-18hr    668 embryo 18-20hr    624 embryo 20-22hr    657 embryo 22-24hr    700 larva L1    839 larva L2    256 larva L3 12hr old    73 larva L3 puffstage 1-2    125 larva L3 puffstage 3-6    219 larva L3 puffstage 7-9    327 white prepupae new    359 white prepupae 12hr    540 white prepupae 24hr    508 pupae 2d postWPP    579 pupae 3d postWPP    1627 pupae 4d postWPP    4129 adult male 01day    1999 adult male 05day    2081 adult male 30day    1984 adult female 01day    1017 adult female 05day    297 adult female 30day    232 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    18 embryo 04-06hr    33 embryo 06-08hr    28 embryo 08-10hr    39 embryo 10-12hr    141 embryo 12-14hr    189 embryo 14-16hr    413 embryo 16-18hr    668 embryo 18-20hr    624 embryo 20-22hr    657 embryo 22-24hr    700 larva L1    839 larva L2    256 larva L3 12hr old    73 larva L3 puffstage 1-2    125 larva L3 puffstage 3-6    219 larva L3 puffstage 7-9    327 white prepupae new    359 white prepupae 12hr    540 white prepupae 24hr    508 pupae 2d postWPP    579 pupae 3d postWPP    1627 pupae 4d postWPP    4129 adult male 01day    1999 adult male 05day    2081 adult male 30day    1984 adult female 01day    1017 adult female 05day    297 adult female 30day    232 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033054 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    18 embryo 04-06hr    33 embryo 06-08hr    28 embryo 08-10hr    39 embryo 10-12hr    141 embryo 12-14hr    189 embryo 14-16hr    413 embryo 16-18hr    668 embryo 18-20hr    624 embryo 20-22hr    657 embryo 22-24hr    700 larva L1    839 larva L2    256 larva L3 12hr old    73 larva L3 puffstage 1-2    125 larva L3 puffstage 3-6    219 larva L3 puffstage 7-9    327 white prepupae new    359 white prepupae 12hr    540 white prepupae 24hr    508 pupae 2d postWPP    579 pupae 3d postWPP    1627 pupae 4d postWPP    4129 adult male 01day    1999 adult male 05day    2081 adult male 30day    1984 adult female 01day    1017 adult female 05day    297 adult female 30day    232 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    18 embryo 04-06hr    33 embryo 06-08hr    28 embryo 08-10hr    39 embryo 10-12hr  141 embryo 12-14hr  (189) embryo 14-16hr  (413) embryo 16-18hr  (668) embryo 18-20hr  (624) embryo 20-22hr  (657) embryo 22-24hr  (700) larva L1  (839) larva L2  (256) larva L3 12hr old    73 larva L3 puffstage 1-2  125 larva L3 puffstage 3-6  (219) larva L3 puffstage 7-9  (327) white prepupae new  (359) white prepupae 12hr  (540) white prepupae 24hr  (508) pupae 2d postWPP  (579) pupae 3d postWPP  (1627) pupae 4d postWPP  (4129) adult male 01day  (1999) adult male 05day  (2081) adult male 30day  (1984) adult female 01day  (1017) adult female 05day  (297) adult female 30day  (232) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    18 embryo 04-06hr    33 embryo 06-08hr    28 embryo 08-10hr    39 embryo 10-12hr    141 embryo 12-14hr    189 embryo 14-16hr    413 embryo 16-18hr    668 embryo 18-20hr    624 embryo 20-22hr    657 embryo 22-24hr    700 larva L1    839 larva L2    256 larva L3 12hr old    73 larva L3 puffstage 1-2    125 larva L3 puffstage 3-6    219 larva L3 puffstage 7-9    327 white prepupae new    359 white prepupae 12hr    540 white prepupae 24hr    508 pupae 2d postWPP    579 pupae 3d postWPP  1627 pupae 4d postWPP  (4129) adult male 01day  1999 adult male 05day  2081 adult male 30day  1984 adult female 01day    1017 adult female 05day    297 adult female 30day    232 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    18 embryo 04-06hr    33 embryo 06-08hr    28 embryo 08-10hr    39 embryo 10-12hr    141 embryo 12-14hr    189 embryo 14-16hr    413 embryo 16-18hr    668 embryo 18-20hr    624 embryo 20-22hr    657 embryo 22-24hr    700 larva L1    839 larva L2    256 larva L3 12hr old    73 larva L3 puffstage 1-2    125 larva L3 puffstage 3-6    219 larva L3 puffstage 7-9    327 white prepupae new    359 white prepupae 12hr    540 white prepupae 24hr    508 pupae 2d postWPP    579 pupae 3d postWPP    1627 pupae 4d postWPP    4129 adult male 01day    1999 adult male 05day    2081 adult male 30day    1984 adult female 01day    1017 adult female 05day    297 adult female 30day    232 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    18 embryo 04-06hr    33 embryo 06-08hr    28 embryo 08-10hr    39 embryo 10-12hr    141 embryo 12-14hr    189 embryo 14-16hr    413 embryo 16-18hr    668 embryo 18-20hr    624 embryo 20-22hr    657 embryo 22-24hr    700 larva L1    839 larva L2    256 larva L3 12hr old    73 larva L3 puffstage 1-2    125 larva L3 puffstage 3-6    219 larva L3 puffstage 7-9    327 white prepupae new    359 white prepupae 12hr    540 white prepupae 24hr    508 pupae 2d postWPP    579 pupae 3d postWPP    1627 pupae 4d postWPP    4129 adult male 01day    1999 adult male 05day    2081 adult male 30day    1984 adult female 01day    1017 adult female 05day    297 adult female 30day    232 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033054    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033054 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033054 expression level Tissue   Expression Level Larval Central Nervous System    265.25 Larval Midgut no informative data Larval Hindgut    2.9 Larval Malpighian Tubules    4.9 Larval Fat Body no informative data Larval Salivary Gland    6.8 Larval Trachea no informative data Larval Carcass    5.55 Adult Head    711.7 Adult Eye    1989 Adult Brain    620.5 Adult Thoracic-Abdominal Ganglion    782.1 Adult Crop    20.5 Adult Midgut no informative data Adult Hindgut    5.6 Adult Malpighian Tubules    6.1 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1 Adult Testis    70.9 Adult Male Accessory Gland    2 Adult Carcass    101.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    265.25 Larval Midgut no informative data Larval Hindgut    2.9 Larval Malpighian Tubules    4.9 Larval Fat Body no informative data Larval Salivary Gland    6.8 Larval Trachea no informative data Larval Carcass    5.55 Adult Head  (711.7) Adult Eye  (1989) Adult Brain  (620.5) Adult Thoracic-Abdominal Ganglion  (782.1) Adult Crop    20.5 Adult Midgut no informative data Adult Hindgut    5.6 Adult Malpighian Tubules    6.1 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1 Adult Testis    70.9 Adult Male Accessory Gland    2 Adult Carcass    101.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    265.25 Larval Midgut no informative data Larval Hindgut    2.9 Larval Malpighian Tubules    4.9 Larval Fat Body no informative data Larval Salivary Gland    6.8 Larval Trachea no informative data Larval Carcass    5.55 Adult Head    711.7 Adult Eye  (1989) Adult Brain    620.5 Adult Thoracic-Abdominal Ganglion    782.1 Adult Crop    20.5 Adult Midgut no informative data Adult Hindgut    5.6 Adult Malpighian Tubules    6.1 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1 Adult Testis    70.9 Adult Male Accessory Gland    2 Adult Carcass    101.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    265.25 Larval Midgut no informative data Larval Hindgut    2.9 Larval Malpighian Tubules    4.9 Larval Fat Body no informative data Larval Salivary Gland    6.8 Larval Trachea no informative data Larval Carcass    5.55 Adult Head    711.7 Adult Eye    1989 Adult Brain    620.5 Adult Thoracic-Abdominal Ganglion    782.1 Adult Crop    20.5 Adult Midgut no informative data Adult Hindgut    5.6 Adult Malpighian Tubules    6.1 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1 Adult Testis    70.9 Adult Male Accessory Gland    2 Adult Carcass    101.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033054 expression level Tissue   Expression Level Larval Central Nervous System    265.25 Larval Midgut no informative data Larval Hindgut    2.9 Larval Malpighian Tubules    4.9 Larval Fat Body no informative data Larval Salivary Gland    6.8 Larval Trachea no informative data Larval Carcass    5.55 Adult Head    711.7 Adult Eye    1989 Adult Brain    620.5 Adult Thoracic-Abdominal Ganglion    782.1 Adult Crop    20.5 Adult Midgut no informative data Adult Hindgut    5.6 Adult Malpighian Tubules    6.1 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1 Adult Testis    70.9 Adult Male Accessory Gland    2 Adult Carcass    101.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    265.25 Larval Midgut no informative data Larval Hindgut    2.9 Larval Malpighian Tubules    4.9 Larval Fat Body no informative data Larval Salivary Gland    6.8 Larval Trachea no informative data Larval Carcass    5.55 Adult Head  711.7 Adult Eye  (1989) Adult Brain  620.5 Adult Thoracic-Abdominal Ganglion  782.1 Adult Crop    20.5 Adult Midgut no informative data Adult Hindgut    5.6 Adult Malpighian Tubules    6.1 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1 Adult Testis    70.9 Adult Male Accessory Gland    2 Adult Carcass    101.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    265.25 Larval Midgut no informative data Larval Hindgut    2.9 Larval Malpighian Tubules    4.9 Larval Fat Body no informative data Larval Salivary Gland    6.8 Larval Trachea no informative data Larval Carcass    5.55 Adult Head    711.7 Adult Eye  (1989) Adult Brain    620.5 Adult Thoracic-Abdominal Ganglion    782.1 Adult Crop    20.5 Adult Midgut no informative data Adult Hindgut    5.6 Adult Malpighian Tubules    6.1 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1 Adult Testis    70.9 Adult Male Accessory Gland    2 Adult Carcass    101.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    265.25 Larval Midgut no informative data Larval Hindgut    2.9 Larval Malpighian Tubules    4.9 Larval Fat Body no informative data Larval Salivary Gland    6.8 Larval Trachea no informative data Larval Carcass    5.55 Adult Head    711.7 Adult Eye    1989 Adult Brain    620.5 Adult Thoracic-Abdominal Ganglion    782.1 Adult Crop    20.5 Adult Midgut no informative data Adult Hindgut    5.6 Adult Malpighian Tubules    6.1 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1 Adult Testis    70.9 Adult Male Accessory Gland    2 Adult Carcass    101.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea no informative data Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    711.7   NA  Eye    1989   NA  Brain    620.5   265.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    782.1   NA  Crop    20.5   no informative data  Midgut    no informative data   2.9  Hindgut    5.6   4.9  Malpighian Tubules    6.1   no informative data  Fat Body    no informative data   6.8  Salivary Gland    no informative data   NA  Heart    4.5   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    1   NA  Testis    70.9   NA  Male Accessory Gland    2   5.55  Carcass    101.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033054 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14591-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG14591 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG14591LH260 viable, with Scer\GAL4pnr-MD237 CG14591GD1813 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG14591 Class Mutagen Stocks Known lesion CG14591MI01876 1 -- CG14591LH15 Delta2-3 0 Yes CG14591LH260 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG14591 Class Mutagen Stocks Known lesion CG14591GD1813 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG14591KK101544 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7085 (Ryder, 2004.4.26)
Not disrupted in	Df(2R)SCAPΔ910 (Matthews et al., 2010)
Partially disrupted in	Df(2R)tbceLH15 (Jin et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1813} NA P{KK101544} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}CG14591MI01876 NA P{GT1}BG01672BG01672 NA P{SUPor-P}KG09112 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG14591 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0033054
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13824 Dere\GG10837 Dgri\GH22818 Dmoj\GI21194 Dper\GL17784 Dpse\GA13101 Dsec\GM16487 Dsim\GD10339 Dvir\GJ20798 Dwil\GK22003 Dyak\GE19431
Curated drosophilid orthologs	Dpse\GA13101
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008760-PA Aedes aegypti (mosquito) AGAP012707-PA Anopheles gambiae (mosquito) XP_396516.2 Apis mellifera (honey bee) 120158 Branchiostoma floridae (lancelet) XP_001899661.1 Brugia malayi (roundworm nematode) CN21323 Caenorhabditis brenneri (small nematode) CBP10616 Caenorhabditis briggsae (nematode) CE41304 Caenorhabditis elegans (worm) ENSCAFP00000026726 Canis familiaris (dog) ENSCINP00000008479 Ciona intestinalis (sea squirt) CPIJ016127 Culex pipens (mosquito) ENSCPOP00000004860 Cavia porcellus (guinea pig) RP30985 Caenorhabditis remanei (nematode) ENSCSAVP00000014445 Ciona savignyi (sedentary tunicate) 93026 Capitella spl (polychaete worm) 61547 Daphnia pulex (daphnia) ENSECAP00000005667 Equus caballus (horse) ENSGACP00000026812 Gymnopilus aculeatus (mushroom) ENSGALP00000013094 Gallus gallus (chicken) 183886 Hypsipyla robusta (cedar shoot borer) ENSP00000361143 Homo sapiens (human) 55380 Lottia gigantea (owl limpet) ENSMODP00000037993 Monodelphis domestica (gray opossum) ENSMMUP00000030050 Macaca mulatta (rhesus monkey) ENSMUSP00000108518 Mus musculus (house mouse) 186001 Nematostella vectensis (starlet anemone) XP_001606307.1 Nasonia vitripennis (wasp) ENSORLP00000013062 Oryzias latipes (japanese killifish) PHUM005000-PA Pediculus humanus (human body louse) PP22571 Pristionchus pacificus (nematode) ENSPPYP00000023092 Pongo pygmaeus (orangutan) ENSRNOP00000005633 Rattus norvegicus (norway rat) Smp_146490 Schistosoma mansoni (trematode parasite) XP_001199575.1 Strongylocentrotus purpuratus (purple sea urchin) 38465 Trichoplax adhaerens (metazoa) XP_973485.1 Tribolium castaneum (red flour beetle) ENSTRUP00000005470 Takifugu rubripes (pufferfish Takifugu) 3686.m00025 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000027170 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15950 NV11690 LH20328 FBgn0236774 FBgn0223988 FBgn0207935 FBgn0182111 FBgn0171402 JGI_V11_61547 FBgn0073139 FBgn0155387 FBgn0143924 FBgn0130275 FBgn0103142 FBgn0090851 CPIJ016127 GB18878 AGAP012707 AAEL008760 PHUM137580 GLEAN_10398
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	34256 y1 w*; Mi{MIC}CG14591MI01876
VDRC	v9945 w1118; P{GD1813}v9945 v9944 w1118; P{GD1813}v9944/TM3
Genomic Clones ( 2 )
	BACR13P06 BACR39E09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 32 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH09039 RH47694
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH19183 RH23533 RH25248 RH27926 RH49867
Other clones	12778 16738 43583 56660 57141 83234 125530 167335 214287.43 CK01.34C.D5 CK01.69B.D8 EK046506 EK055447 EK065434 EK114257 EK128053 EK162915 EK179807 EP18513 RP004237944 RP004242810 RP004410373 RP004426657 RP004442626 SD05652
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033054 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35531
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136352 NM_165456 NM_001201935 NM_001201936 RefSeq (Proteins) • NP_610196 NP_724447 NP_001188864 NP_001188865 DDBJ / EMBL / GenBank • AAF57289 AAL68345 AAM68341 AAN71586 ADV37113 ADV37114 AY075538 BI573388 BI573389 BI617378 BT001831 Entrez Gene - A searchable database of RefSeq genes. • 35531 UniProtKB/TrEMBL • Q7JRB2
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0033054 DRSC - Results from RNAi screens. • FBgn0033054 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033054 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14591-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033054 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35531 InParanoid A subset of ortholog calls from InParanoid. • AAEL008760-PA Aedes aegypti (mosquito) AGAP012707-PA Anopheles gambiae (mosquito) XP_396516.2 Apis mellifera (honey bee) 120158 Branchiostoma floridae (lancelet) XP_001899661.1 Brugia malayi (roundworm nematode) CN21323 Caenorhabditis brenneri (small nematode) CBP10616 Caenorhabditis briggsae (nematode) CE41304 Caenorhabditis elegans (worm) ENSCAFP00000026726 Canis familiaris (dog) ENSCINP00000008479 Ciona intestinalis (sea squirt) CPIJ016127 Culex pipens (mosquito) ENSCPOP00000004860 Cavia porcellus (guinea pig) RP30985 Caenorhabditis remanei (nematode) ENSCSAVP00000014445 Ciona savignyi (sedentary tunicate) 93026 Capitella spl (polychaete worm) 61547 Daphnia pulex (daphnia) ENSECAP00000005667 Equus caballus (horse) ENSGACP00000026812 Gymnopilus aculeatus (mushroom) ENSGALP00000013094 Gallus gallus (chicken) 183886 Hypsipyla robusta (cedar shoot borer) ENSP00000361143 Homo sapiens (human) 55380 Lottia gigantea (owl limpet) ENSMODP00000037993 Monodelphis domestica (gray opossum) ENSMMUP00000030050 Macaca mulatta (rhesus monkey) ENSMUSP00000108518 Mus musculus (house mouse) 186001 Nematostella vectensis (starlet anemone) XP_001606307.1 Nasonia vitripennis (wasp) ENSORLP00000013062 Oryzias latipes (japanese killifish) PHUM005000-PA Pediculus humanus (human body louse) PP22571 Pristionchus pacificus (nematode) ENSPPYP00000023092 Pongo pygmaeus (orangutan) ENSRNOP00000005633 Rattus norvegicus (norway rat) Smp_146490 Schistosoma mansoni (trematode parasite) XP_001199575.1 Strongylocentrotus purpuratus (purple sea urchin) 38465 Trichoplax adhaerens (metazoa) XP_973485.1 Tribolium castaneum (red flour beetle) ENSTRUP00000005470 Takifugu rubripes (pufferfish Takifugu) 3686.m00025 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000027170 Xenopus tropicalis (frog) modMine - Data generated by the modENCODE project. • FBgn0033054 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15950 NV11690 LH20328 FBgn0236774 FBgn0223988 FBgn0207935 FBgn0182111 FBgn0171402 JGI_V11_61547 FBgn0073139 FBgn0155387 FBgn0143924 FBgn0130275 FBgn0103142 FBgn0090851 CPIJ016127 GB18878 AGAP012707 AAEL008760 PHUM137580 GLEAN_10398
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG14591 (Sambandan et al., 2006, Mensch et al., 2008, Jin et al., 2009, Morozova et al., 2007, Mensch et al., 2010, Matthews et al., 2010, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 17 )
Research paper	Morozova et al., 2011, Genetics 187(4): 1193--1205 Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. [FBrf0214377] Matthews et al., 2010, Genetics 185(1): 189--198 Activation of Sterol Regulatory Element Binding Proteins in the Absence of Scap in Drosophila melanogaster. [FBrf0210903] Mensch et al., 2010, PLoS ONE 5(6): e11229 Stage-Specific Effects of Candidate Heterochronic Genes on Variation in Developmental Time along an Altitudinal Cline of Drosophila melanogaster. [FBrf0211152] Jin et al., 2009, Development 136(9): 1571--1581 Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation. [FBrf0209976] Mensch et al., 2008, BMC Dev. Biol. 8: 78 Identifying candidate genes affecting developmental time in Drosophila melanogaster: pervasive pleiotropy and gene-by-environment interaction. [FBrf0205813] Morozova et al., 2007, Genome Biol. 8(10): R231 Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. [FBrf0205161] Sambandan et al., 2006, Genetics 174(3): 1349--1363 Dynamic genetic interactions determine odor-guided behavior in Drosophila melanogaster. [FBrf0192106]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Bellen, 2011.1.31, set919.xml set919.xml [FBrf0212923] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]