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Gene Dmel\Dpit47

General Information
Symbol	Dmel\Dpit47	Species	D. melanogaster
Name	DNA polymerase interacting tpr containing protein of 47kD	Annotation symbol	CG3189
Feature type	protein_coding_gene	FlyBase ID	FBgn0033083
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	42C3-42C3	Sequence location	2R:2,548,155..2,549,623 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene DNA polymerase interacting tpr containing protein of 47kD is referred to in FlyBase by the symbol Dmel\Dpit47 (CG3189, FBgn0033083). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Tetratricopeptide repeat; Tetratricopeptide repeat-containing; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1636273_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Dpit47. Gene sequence location is 2R:2548155..2549623.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN21437 HFA04985
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42C3-42C3   Limits computationally determined from genome sequence between P{lacW}geminink14019&P{PZ}Adf101349 and P{lacW}ublk03203&P{PZ}CG328709967
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dpit47 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dpit47-RA FBtr0086146  NM_080367   1412   396
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dpit47-PA   FBpp0085479   46.9   396   5.98     NP_525106   AAF57368
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing (IPR013026) Tetratricopeptide repeat (IPR019734)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57368   AI517329   BF485727   BF496132   BI238487   BI240490   BI374175   BP552603   BP552604   BT011560   BX019010   CK657807   CO338654   DU708641   EC083162   EC201870   EC264422   EV578574   EV579787
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z6M6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033083    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033083 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033083 expression level Developmental Stage   Expression Level embryo 00-02hr    3797 embryo 02-04hr    2204 embryo 04-06hr    1064 embryo 06-08hr    1843 embryo 08-10hr    2287 embryo 10-12hr    2688 embryo 12-14hr    1286 embryo 14-16hr    1011 embryo 16-18hr    654 embryo 18-20hr    613 embryo 20-22hr    549 embryo 22-24hr    550 larva L1    1525 larva L2    1229 larva L3 12hr old    903 larva L3 puffstage 1-2    1010 larva L3 puffstage 3-6    1319 larva L3 puffstage 7-9    1409 white prepupae new    1213 white prepupae 12hr    1768 white prepupae 24hr    1795 pupae 2d postWPP    952 pupae 3d postWPP    690 pupae 4d postWPP    828 adult male 01day    1102 adult male 05day    1416 adult male 30day    1347 adult female 01day    1919 adult female 05day    2729 adult female 30day    3026 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3797) embryo 02-04hr  (2204) embryo 04-06hr  (1064) embryo 06-08hr  (1843) embryo 08-10hr  (2287) embryo 10-12hr  (2688) embryo 12-14hr  (1286) embryo 14-16hr  (1011) embryo 16-18hr  (654) embryo 18-20hr  (613) embryo 20-22hr  (549) embryo 22-24hr  (550) larva L1  (1525) larva L2  (1229) larva L3 12hr old  (903) larva L3 puffstage 1-2  (1010) larva L3 puffstage 3-6  (1319) larva L3 puffstage 7-9  (1409) white prepupae new  (1213) white prepupae 12hr  (1768) white prepupae 24hr  (1795) pupae 2d postWPP  (952) pupae 3d postWPP  (690) pupae 4d postWPP  (828) adult male 01day  (1102) adult male 05day  (1416) adult male 30day  (1347) adult female 01day  (1919) adult female 05day  (2729) adult female 30day  (3026) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3797) embryo 02-04hr  (2204) embryo 04-06hr    1064 embryo 06-08hr  (1843) embryo 08-10hr  (2287) embryo 10-12hr  (2688) embryo 12-14hr    1286 embryo 14-16hr    1011 embryo 16-18hr    654 embryo 18-20hr    613 embryo 20-22hr    549 embryo 22-24hr    550 larva L1  (1525) larva L2    1229 larva L3 12hr old    903 larva L3 puffstage 1-2    1010 larva L3 puffstage 3-6    1319 larva L3 puffstage 7-9  1409 white prepupae new    1213 white prepupae 12hr  (1768) white prepupae 24hr  (1795) pupae 2d postWPP    952 pupae 3d postWPP    690 pupae 4d postWPP    828 adult male 01day    1102 adult male 05day  1416 adult male 30day    1347 adult female 01day  (1919) adult female 05day  (2729) adult female 30day  (3026) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3797 embryo 02-04hr    2204 embryo 04-06hr    1064 embryo 06-08hr    1843 embryo 08-10hr    2287 embryo 10-12hr    2688 embryo 12-14hr    1286 embryo 14-16hr    1011 embryo 16-18hr    654 embryo 18-20hr    613 embryo 20-22hr    549 embryo 22-24hr    550 larva L1    1525 larva L2    1229 larva L3 12hr old    903 larva L3 puffstage 1-2    1010 larva L3 puffstage 3-6    1319 larva L3 puffstage 7-9    1409 white prepupae new    1213 white prepupae 12hr    1768 white prepupae 24hr    1795 pupae 2d postWPP    952 pupae 3d postWPP    690 pupae 4d postWPP    828 adult male 01day    1102 adult male 05day    1416 adult male 30day    1347 adult female 01day    1919 adult female 05day    2729 adult female 30day    3026 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3797 embryo 02-04hr    2204 embryo 04-06hr    1064 embryo 06-08hr    1843 embryo 08-10hr    2287 embryo 10-12hr    2688 embryo 12-14hr    1286 embryo 14-16hr    1011 embryo 16-18hr    654 embryo 18-20hr    613 embryo 20-22hr    549 embryo 22-24hr    550 larva L1    1525 larva L2    1229 larva L3 12hr old    903 larva L3 puffstage 1-2    1010 larva L3 puffstage 3-6    1319 larva L3 puffstage 7-9    1409 white prepupae new    1213 white prepupae 12hr    1768 white prepupae 24hr    1795 pupae 2d postWPP    952 pupae 3d postWPP    690 pupae 4d postWPP    828 adult male 01day    1102 adult male 05day    1416 adult male 30day    1347 adult female 01day    1919 adult female 05day    2729 adult female 30day    3026 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033083 expression level Developmental Stage   Expression Level embryo 00-02hr    3797 embryo 02-04hr    2204 embryo 04-06hr    1064 embryo 06-08hr    1843 embryo 08-10hr    2287 embryo 10-12hr    2688 embryo 12-14hr    1286 embryo 14-16hr    1011 embryo 16-18hr    654 embryo 18-20hr    613 embryo 20-22hr    549 embryo 22-24hr    550 larva L1    1525 larva L2    1229 larva L3 12hr old    903 larva L3 puffstage 1-2    1010 larva L3 puffstage 3-6    1319 larva L3 puffstage 7-9    1409 white prepupae new    1213 white prepupae 12hr    1768 white prepupae 24hr    1795 pupae 2d postWPP    952 pupae 3d postWPP    690 pupae 4d postWPP    828 adult male 01day    1102 adult male 05day    1416 adult male 30day    1347 adult female 01day    1919 adult female 05day    2729 adult female 30day    3026 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3797) embryo 02-04hr  (2204) embryo 04-06hr  (1064) embryo 06-08hr  (1843) embryo 08-10hr  (2287) embryo 10-12hr  (2688) embryo 12-14hr  (1286) embryo 14-16hr  (1011) embryo 16-18hr  (654) embryo 18-20hr  (613) embryo 20-22hr  (549) embryo 22-24hr  (550) larva L1  (1525) larva L2  (1229) larva L3 12hr old  (903) larva L3 puffstage 1-2  (1010) larva L3 puffstage 3-6  (1319) larva L3 puffstage 7-9  (1409) white prepupae new  (1213) white prepupae 12hr  (1768) white prepupae 24hr  (1795) pupae 2d postWPP  (952) pupae 3d postWPP  (690) pupae 4d postWPP  (828) adult male 01day  (1102) adult male 05day  (1416) adult male 30day  (1347) adult female 01day  (1919) adult female 05day  (2729) adult female 30day  (3026) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3797) embryo 02-04hr  2204 embryo 04-06hr    1064 embryo 06-08hr  1843 embryo 08-10hr  2287 embryo 10-12hr  (2688) embryo 12-14hr    1286 embryo 14-16hr    1011 embryo 16-18hr    654 embryo 18-20hr    613 embryo 20-22hr    549 embryo 22-24hr    550 larva L1  1525 larva L2    1229 larva L3 12hr old    903 larva L3 puffstage 1-2    1010 larva L3 puffstage 3-6    1319 larva L3 puffstage 7-9  1409 white prepupae new    1213 white prepupae 12hr  1768 white prepupae 24hr  1795 pupae 2d postWPP    952 pupae 3d postWPP    690 pupae 4d postWPP    828 adult male 01day    1102 adult male 05day  1416 adult male 30day    1347 adult female 01day  1919 adult female 05day  (2729) adult female 30day  (3026) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3797 embryo 02-04hr    2204 embryo 04-06hr    1064 embryo 06-08hr    1843 embryo 08-10hr    2287 embryo 10-12hr    2688 embryo 12-14hr    1286 embryo 14-16hr    1011 embryo 16-18hr    654 embryo 18-20hr    613 embryo 20-22hr    549 embryo 22-24hr    550 larva L1    1525 larva L2    1229 larva L3 12hr old    903 larva L3 puffstage 1-2    1010 larva L3 puffstage 3-6    1319 larva L3 puffstage 7-9    1409 white prepupae new    1213 white prepupae 12hr    1768 white prepupae 24hr    1795 pupae 2d postWPP    952 pupae 3d postWPP    690 pupae 4d postWPP    828 adult male 01day    1102 adult male 05day    1416 adult male 30day    1347 adult female 01day    1919 adult female 05day    2729 adult female 30day    3026 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3797 embryo 02-04hr    2204 embryo 04-06hr    1064 embryo 06-08hr    1843 embryo 08-10hr    2287 embryo 10-12hr    2688 embryo 12-14hr    1286 embryo 14-16hr    1011 embryo 16-18hr    654 embryo 18-20hr    613 embryo 20-22hr    549 embryo 22-24hr    550 larva L1    1525 larva L2    1229 larva L3 12hr old    903 larva L3 puffstage 1-2    1010 larva L3 puffstage 3-6    1319 larva L3 puffstage 7-9    1409 white prepupae new    1213 white prepupae 12hr    1768 white prepupae 24hr    1795 pupae 2d postWPP    952 pupae 3d postWPP    690 pupae 4d postWPP    828 adult male 01day    1102 adult male 05day    1416 adult male 30day    1347 adult female 01day    1919 adult female 05day    2729 adult female 30day    3026 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033083    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033083 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033083 expression level Tissue   Expression Level Larval Central Nervous System    158.6 Larval Midgut    35.7 Larval Hindgut    57.4 Larval Malpighian Tubules    61.6 Larval Fat Body    30.3 Larval Salivary Gland    63.6 Larval Trachea    113.925 Larval Carcass    81.85 Adult Head    55.7 Adult Eye    69.9 Adult Brain    65 Adult Thoracic-Abdominal Ganglion    63.7 Adult Crop    77.8 Adult Midgut    59.3 Adult Hindgut    76.5 Adult Malpighian Tubules    74.2 Adult Fat Body    54.8 Adult Salivary Gland    62.3 Adult Heart    45.425 Adult VirginFemale Spermatheca    48.6 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    124.2 Adult Testis    30.9 Adult Male Accessory Gland    90.5 Adult Carcass    57.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    158.6 Larval Midgut    35.7 Larval Hindgut    57.4 Larval Malpighian Tubules    61.6 Larval Fat Body    30.3 Larval Salivary Gland    63.6 Larval Trachea    113.925 Larval Carcass    81.85 Adult Head    55.7 Adult Eye    69.9 Adult Brain    65 Adult Thoracic-Abdominal Ganglion    63.7 Adult Crop    77.8 Adult Midgut    59.3 Adult Hindgut    76.5 Adult Malpighian Tubules    74.2 Adult Fat Body    54.8 Adult Salivary Gland    62.3 Adult Heart    45.425 Adult VirginFemale Spermatheca    48.6 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    124.2 Adult Testis    30.9 Adult Male Accessory Gland    90.5 Adult Carcass    57.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    158.6 Larval Midgut    35.7 Larval Hindgut    57.4 Larval Malpighian Tubules    61.6 Larval Fat Body    30.3 Larval Salivary Gland    63.6 Larval Trachea    113.925 Larval Carcass    81.85 Adult Head    55.7 Adult Eye    69.9 Adult Brain    65 Adult Thoracic-Abdominal Ganglion    63.7 Adult Crop    77.8 Adult Midgut    59.3 Adult Hindgut    76.5 Adult Malpighian Tubules    74.2 Adult Fat Body    54.8 Adult Salivary Gland    62.3 Adult Heart    45.425 Adult VirginFemale Spermatheca    48.6 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    124.2 Adult Testis    30.9 Adult Male Accessory Gland    90.5 Adult Carcass    57.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    158.6 Larval Midgut    35.7 Larval Hindgut    57.4 Larval Malpighian Tubules    61.6 Larval Fat Body    30.3 Larval Salivary Gland    63.6 Larval Trachea    113.925 Larval Carcass    81.85 Adult Head    55.7 Adult Eye    69.9 Adult Brain    65 Adult Thoracic-Abdominal Ganglion    63.7 Adult Crop    77.8 Adult Midgut    59.3 Adult Hindgut    76.5 Adult Malpighian Tubules    74.2 Adult Fat Body    54.8 Adult Salivary Gland    62.3 Adult Heart    45.425 Adult VirginFemale Spermatheca    48.6 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    124.2 Adult Testis    30.9 Adult Male Accessory Gland    90.5 Adult Carcass    57.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033083 expression level Tissue   Expression Level Larval Central Nervous System    158.6 Larval Midgut    35.7 Larval Hindgut    57.4 Larval Malpighian Tubules    61.6 Larval Fat Body    30.3 Larval Salivary Gland    63.6 Larval Trachea    113.925 Larval Carcass    81.85 Adult Head    55.7 Adult Eye    69.9 Adult Brain    65 Adult Thoracic-Abdominal Ganglion    63.7 Adult Crop    77.8 Adult Midgut    59.3 Adult Hindgut    76.5 Adult Malpighian Tubules    74.2 Adult Fat Body    54.8 Adult Salivary Gland    62.3 Adult Heart    45.425 Adult VirginFemale Spermatheca    48.6 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    124.2 Adult Testis    30.9 Adult Male Accessory Gland    90.5 Adult Carcass    57.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    158.6 Larval Midgut    35.7 Larval Hindgut    57.4 Larval Malpighian Tubules    61.6 Larval Fat Body    30.3 Larval Salivary Gland    63.6 Larval Trachea    113.925 Larval Carcass    81.85 Adult Head    55.7 Adult Eye    69.9 Adult Brain    65 Adult Thoracic-Abdominal Ganglion    63.7 Adult Crop    77.8 Adult Midgut    59.3 Adult Hindgut    76.5 Adult Malpighian Tubules    74.2 Adult Fat Body    54.8 Adult Salivary Gland    62.3 Adult Heart    45.425 Adult VirginFemale Spermatheca    48.6 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    124.2 Adult Testis    30.9 Adult Male Accessory Gland    90.5 Adult Carcass    57.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    158.6 Larval Midgut    35.7 Larval Hindgut    57.4 Larval Malpighian Tubules    61.6 Larval Fat Body    30.3 Larval Salivary Gland    63.6 Larval Trachea    113.925 Larval Carcass    81.85 Adult Head    55.7 Adult Eye    69.9 Adult Brain    65 Adult Thoracic-Abdominal Ganglion    63.7 Adult Crop    77.8 Adult Midgut    59.3 Adult Hindgut    76.5 Adult Malpighian Tubules    74.2 Adult Fat Body    54.8 Adult Salivary Gland    62.3 Adult Heart    45.425 Adult VirginFemale Spermatheca    48.6 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    124.2 Adult Testis    30.9 Adult Male Accessory Gland    90.5 Adult Carcass    57.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    158.6 Larval Midgut    35.7 Larval Hindgut    57.4 Larval Malpighian Tubules    61.6 Larval Fat Body    30.3 Larval Salivary Gland    63.6 Larval Trachea    113.925 Larval Carcass    81.85 Adult Head    55.7 Adult Eye    69.9 Adult Brain    65 Adult Thoracic-Abdominal Ganglion    63.7 Adult Crop    77.8 Adult Midgut    59.3 Adult Hindgut    76.5 Adult Malpighian Tubules    74.2 Adult Fat Body    54.8 Adult Salivary Gland    62.3 Adult Heart    45.425 Adult VirginFemale Spermatheca    48.6 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    124.2 Adult Testis    30.9 Adult Male Accessory Gland    90.5 Adult Carcass    57.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    55.7   NA  Eye    69.9   NA  Brain    65   158.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    63.7   NA  Crop    77.8   35.7  Midgut    59.3   57.4  Hindgut    76.5   61.6  Malpighian Tubules    74.2   30.3  Fat Body    54.8   63.6  Salivary Gland    62.3   NA  Heart    45.425   113.925  Trachea    NA   NA  VirginFemale Spermatheca    48.6   NA  InseminatedFemale Spermatheca    65.5   NA  Ovary    124.2   NA  Testis    30.9   NA  Male Accessory Gland    90.5   81.85  Carcass    57.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033083 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3189-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Dpit47LA00491 viable, with Scer\GAL4pnr-MD237 Dpit47GD10397 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Dpit47 Class Mutagen Stocks Known lesion Dpit47LA00491 P-element activity 2 -- Dpit4704065 P-element activity 0 -- Dpit47SH1569 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dpit47 Class Mutagen Stocks Known lesion Dpit47GD10397 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dpit47KK101386 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)hfl-37 (Rendina et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10397} NA P{KK101386} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Dpit47SH1569 No P{PZ}Dpit4704065 No insertion of mobile activating element P{Mae-UAS.6.11}Dpit47LA00491 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Crevel et al., 2001)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR011990 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dpit47 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61464 DroID - A comprehensive database of gene and protein interactions. • FBgn0033083 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35565
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13804 Dere\GG10816 Dgri\GH20065 Dmoj\GI18783 Dper\GL10216 Dpse\GA24121 Dsec\GM20865 Dsim\GD10316 Dvir\GJ21809 Dwil\GK19623 Dyak\GE24643
Curated drosophilid orthologs	Dpse\GA16548
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008743-PA Aedes aegypti (mosquito) AGAP012044-PA Anopheles gambiae (mosquito) XP_624121.1 Apis mellifera (honey bee) XP_001950450.1 Acyrthosiphon pisum (pea aphid) At1g04130.1 Arabidopsis thaliana (wall cress) 21274 Batrachochytrium dendrobatidis (chytrid fungus) 104591 Branchiostoma floridae (lancelet) XP_001898584.1 Brugia malayi (roundworm nematode) BGIBMGA004496-PA Bombyx mori (silk worm) ENSBTAP00000021186 Bos taurus (bovine) CAL0005143 Candida albicans (a form of yeast) CN08303 Caenorhabditis brenneri (small nematode) CBP00586 Caenorhabditis briggsae (nematode) CE29583 Caenorhabditis elegans (worm) ENSCAFP00000028041 Canis familiaris (dog) CAGL0H07425g Candida glabrata (haploid yeast) Chro.70071 Cryptosporidium hominis (obligate parasite) ENSCINP00000016972 Ciona intestinalis (sea squirt) JA09029 Caenorhabditis japonica (nematode) CMT570C Cyanidioschyzon merolae (red alga) cn12269 Cryptococcus neoformans (yeast-like fungus) cgd7_570 Cryptosporidium parvum (protozoan parasite) CPIJ012513 Culex pipens (mosquito) ENSCPOP00000018560 Cavia porcellus (guinea pig) RP28832 Caenorhabditis remanei (nematode) 91257 Capitella spl (polychaete worm) DDB0186885 Dictyostelium discoideum (amoeba) DEHA2D09064g Debaryomyces Hansenii (yeast) 306258 Daphnia pulex (daphnia) ENSDARP00000065211 Danio rerio (zebra fish) ENSECAP00000006270 Equus caballus (horse) XP_652329 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000009576 Gymnopilus aculeatus (mushroom) ENSGALP00000017524 Gallus gallus (chicken) ENSP00000360329 Homo sapiens (human) ISCW017962-PA Ixodes scapularis (deer tick) KLLA0B09966g Kluyveromyces lactis (yeast) 102857 Lottia gigantea (owl limpet) LmjF33.0700 Leishmania major (virus) 33288 Monocosta brevicollis (choanoflagellate) ENSMODP00000004760 Monodelphis domestica (gray opossum) ENSMMUP00000025219 Macaca mulatta (rhesus monkey) ENSMUSP00000026480 Mus musculus (house mouse) 33659 Nematostella vectensis (starlet anemone) XP_001605496.1 Nasonia vitripennis (wasp) ENSORLP00000012423 Oryzias latipes (japanese killifish) LOC_Os03g53910.1 Oryza sativa (asian rice) 9974 Ostreococcus tauri (green alga) PHUM009437-PA Pediculus humanus (human body louse) ENSPPYP00000001529 Pongo pygmaeus (orangutan) 75150 Phytophthora ramorum (sudden oak death pathogen) 133236 Phytophthora sojae (root rot pathogen) 553283 Populus trichocarpa (black cottonwood) 4867874 Sorghum bicolor (sorghum) YBR155W Saccharomyces cerevisiae (budding yeast) Smp_155480 Schistosoma mansoni (trematode parasite) SPAC17A2.04c Schizosaccharomyces pombe (fission yeast) XP_001189962.1 Strongylocentrotus purpuratus (purple sea urchin) 57799 Trichoplax adhaerens (metazoa) XP_001814592.1 Tribolium castaneum (red flour beetle) Tc00.1047053506577.70 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507709.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000021278 Tetraodon nigroviridis (green spotted pufferfish) TP04_0687 Theileria parva (parasitic protozoan) ENSTRUP00000047526 Takifugu rubripes (pufferfish Takifugu) 188.m00064 Tetrahymena thermophila (ciliate protozoa) 96092.m00209 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000043240 Xenopus tropicalis (frog) YALI0F10153g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14140 NV13838 LH22148 ISCW017962 FBgn0241751 FBgn0221621 FBgn0208927 FBgn0182088 FBgn0175746 JGI_V11_306258 FBgn0245520 FBgn0147826 FBgn0141522 FBgn0127529 FBgn0103121 FBgn0090831 CPIJ012513 BGIBMGA004496 ACYPI002014 GB11600 AGAP012044 AAEL008743 PHUM418330 GLEAN_15303
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	22239 y1 w*; P{Mae-UAS.6.11}Dpit47LA00491/CyO; ?/TM3, Sb1 Ser1
Kyoto	120491 y* w*; P{Mae-UAS.6.11}Dpit47LA00491
VDRC	v34017 w1118; P{GD10397}v34017
Genomic Clones ( 1 )
	BACR01C10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT19681
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09849 GH28041 LP24388 RE34965 RE37342 RE61702
Other clones	1996 82701 572886 Dmel_dig_004567_0594_2820 Dmel_dig_015789_0645_2735 EN17312 FGM219G01
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033083 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35565
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Identification: in a yeast two hybrid screen, using DNApol-α180 protein as a bait. (Crevel et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080367 RefSeq (Proteins) • NP_525106 DDBJ / EMBL / GenBank • AAF57368 BF485727 DU708641 Entrez Gene - A searchable database of RefSeq genes. • 35565 UniProtKB/TrEMBL • A1Z6M6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing (IPR013026) Tetratricopeptide repeat (IPR019734)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61464 DroID - A comprehensive database of gene and protein interactions. • FBgn0033083 DRSC - Results from RNAi screens. • FBgn0033083 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033083 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3189-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033083 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35565 InParanoid A subset of ortholog calls from InParanoid. • AAEL008743-PA Aedes aegypti (mosquito) AGAP012044-PA Anopheles gambiae (mosquito) XP_624121.1 Apis mellifera (honey bee) XP_001950450.1 Acyrthosiphon pisum (pea aphid) At1g04130.1 Arabidopsis thaliana (wall cress) 21274 Batrachochytrium dendrobatidis (chytrid fungus) 104591 Branchiostoma floridae (lancelet) XP_001898584.1 Brugia malayi (roundworm nematode) BGIBMGA004496-PA Bombyx mori (silk worm) ENSBTAP00000021186 Bos taurus (bovine) CAL0005143 Candida albicans (a form of yeast) CN08303 Caenorhabditis brenneri (small nematode) CBP00586 Caenorhabditis briggsae (nematode) CE29583 Caenorhabditis elegans (worm) ENSCAFP00000028041 Canis familiaris (dog) CAGL0H07425g Candida glabrata (haploid yeast) Chro.70071 Cryptosporidium hominis (obligate parasite) ENSCINP00000016972 Ciona intestinalis (sea squirt) JA09029 Caenorhabditis japonica (nematode) CMT570C Cyanidioschyzon merolae (red alga) cn12269 Cryptococcus neoformans (yeast-like fungus) cgd7_570 Cryptosporidium parvum (protozoan parasite) CPIJ012513 Culex pipens (mosquito) ENSCPOP00000018560 Cavia porcellus (guinea pig) RP28832 Caenorhabditis remanei (nematode) 91257 Capitella spl (polychaete worm) DDB0186885 Dictyostelium discoideum (amoeba) DEHA2D09064g Debaryomyces Hansenii (yeast) 306258 Daphnia pulex (daphnia) ENSDARP00000065211 Danio rerio (zebra fish) ENSECAP00000006270 Equus caballus (horse) XP_652329 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000009576 Gymnopilus aculeatus (mushroom) ENSGALP00000017524 Gallus gallus (chicken) ENSP00000360329 Homo sapiens (human) ISCW017962-PA Ixodes scapularis (deer tick) KLLA0B09966g Kluyveromyces lactis (yeast) 102857 Lottia gigantea (owl limpet) LmjF33.0700 Leishmania major (virus) 33288 Monocosta brevicollis (choanoflagellate) ENSMODP00000004760 Monodelphis domestica (gray opossum) ENSMMUP00000025219 Macaca mulatta (rhesus monkey) ENSMUSP00000026480 Mus musculus (house mouse) 33659 Nematostella vectensis (starlet anemone) XP_001605496.1 Nasonia vitripennis (wasp) ENSORLP00000012423 Oryzias latipes (japanese killifish) LOC_Os03g53910.1 Oryza sativa (asian rice) 9974 Ostreococcus tauri (green alga) PHUM009437-PA Pediculus humanus (human body louse) ENSPPYP00000001529 Pongo pygmaeus (orangutan) 75150 Phytophthora ramorum (sudden oak death pathogen) 133236 Phytophthora sojae (root rot pathogen) 553283 Populus trichocarpa (black cottonwood) 4867874 Sorghum bicolor (sorghum) YBR155W Saccharomyces cerevisiae (budding yeast) Smp_155480 Schistosoma mansoni (trematode parasite) SPAC17A2.04c Schizosaccharomyces pombe (fission yeast) XP_001189962.1 Strongylocentrotus purpuratus (purple sea urchin) 57799 Trichoplax adhaerens (metazoa) XP_001814592.1 Tribolium castaneum (red flour beetle) Tc00.1047053506577.70 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507709.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000021278 Tetraodon nigroviridis (green spotted pufferfish) TP04_0687 Theileria parva (parasitic protozoan) ENSTRUP00000047526 Takifugu rubripes (pufferfish Takifugu) 188.m00064 Tetrahymena thermophila (ciliate protozoa) 96092.m00209 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000043240 Xenopus tropicalis (frog) YALI0F10153g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35565 modMine - Data generated by the modENCODE project. • FBgn0033083 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14140 NV13838 LH22148 ISCW017962 FBgn0241751 FBgn0221621 FBgn0208927 FBgn0182088 FBgn0175746 JGI_V11_306258 FBgn0245520 FBgn0147826 FBgn0141522 FBgn0127529 FBgn0103121 FBgn0090831 CPIJ012513 BGIBMGA004496 ACYPI002014 GB11600 AGAP012044 AAEL008743 PHUM418330 GLEAN_15303
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG3189 (Gandhi et al., 2007, Keleman et al., 2009.8.5) Dpit47 (Rendina et al., 2010, Ayroles et al., 2009)
Name Synonym	DNA polymerase interacting tpr containing protein of 47kD (Crevel et al., 2001)
Secondary FlyBase IDs
References ( 18 )
Research paper	Ayroles et al., 2009, Nature Genetics 41(3): 299--307 Systems genetics of complex traits in Drosophila melanogaster. [FBrf0206705] Crevel et al., 2001, J. Cell Sci. 114(11): 2015--2025 The Drosophila Dpit47 protein is a nuclear Hsp90 co-chaperone that interacts with DNA polymerase . [FBrf0136756]
Supplementary material	Rendina et al., 2010, Genetics 186(1): Supporting Information. [FBrf0212743] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Gandhi et al., 2007, Nat. Genet. 38(3): Supplementary Information [FBrf0208882] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Merriam, 2005.11.18, Merriam insertions. Merriam insertions. [FBrf0195913] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Li, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126682]