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Gene Dmel\Tsp42Ec

General Information
Symbol	Dmel\Tsp42Ec	Species	D. melanogaster
Name	Tetraspanin 42Ec	Annotation symbol	CG12847
Feature type	protein_coding_gene	FlyBase ID	FBgn0033124
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	42E5-42E5	Sequence location	2R:2,893,952..2,896,127 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Tetraspanin 42Ec is referred to in FlyBase by the symbol Dmel\Tsp42Ec (CG12847, FBgn0033124). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Tetraspanin; Tetraspanin, EC2 domain; Tetraspanin, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. Comments on Affy2 ProbeSet: ProbeSet 1630051_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Tsp42Ec. Gene sequence location is 2R:2893952..2896127.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References FlyBase Curators, 2010-, Gene Ontology (GO) annotation review.
FB2012_01	Sequence features BKN24971 HFA06192
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42E5-42E5   Limits computationally determined from genome sequence between P{lacW}vimark16722 and P{lacW}cosk16101
Experimentally Determined Cytological Location
Cytogenetic map Notes References 42E-42E     (Todres, 2000.6.1)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tsp42Ec for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tsp42Ec-RA FBtr0086179  NM_078905   1020   232
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tsp42Ec-PA   FBpp0085511   25.4   232   4.28     NP_523629   AAF59313
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tetraspanin (IPR018499) Tetraspanin, subgroup (IPR000301) Tetraspanin, EC2 domain (IPR008952)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF59313   AF274016 AAF90142   AI259420   AY118995 AAM50855   CO179932   CO180434   CO291544   CO303547   CO308949   CO309453   CO328216   CO330812   CO339293   EC077123   EC078982   EC084821   EC224010   EC224936   EC249641   EC254101   EC254192   EV576561   GH941932   GH942971   GH943936   GH944355   GH944425   GH946137   GH949124   GH954791   GH954827   GH956282   GH958983   GH959507   GH960029   GH962027   GH963377   GH969627   GH970152   GH970334   GH973226   GH975248   GH978094   GH980602   GH981994   GH982245   GH983260   GH983981   GH984058   GH984616
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9NB13
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033124    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033124 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033124 expression level Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    56 embryo 04-06hr    384 embryo 06-08hr    41 embryo 08-10hr    50 embryo 10-12hr    42 embryo 12-14hr    27 embryo 14-16hr    331 embryo 16-18hr    1669 embryo 18-20hr    5230 embryo 20-22hr    8203 embryo 22-24hr    7748 larva L1    5546 larva L2    3375 larva L3 12hr old    2766 larva L3 puffstage 1-2    4634 larva L3 puffstage 3-6    3626 larva L3 puffstage 7-9    2474 white prepupae new    1332 white prepupae 12hr    523 white prepupae 24hr    113 pupae 2d postWPP    84 pupae 3d postWPP    34 pupae 4d postWPP    961 adult male 01day    1435 adult male 05day    2387 adult male 30day    1719 adult female 01day    2251 adult female 05day    1149 adult female 30day    1475 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    56 embryo 04-06hr  (384) embryo 06-08hr    41 embryo 08-10hr    50 embryo 10-12hr    42 embryo 12-14hr    27 embryo 14-16hr  (331) embryo 16-18hr  (1669) embryo 18-20hr  (5230) embryo 20-22hr  (8203) embryo 22-24hr  (7748) larva L1  (5546) larva L2  (3375) larva L3 12hr old  (2766) larva L3 puffstage 1-2  (4634) larva L3 puffstage 3-6  (3626) larva L3 puffstage 7-9  (2474) white prepupae new  (1332) white prepupae 12hr  (523) white prepupae 24hr  (113) pupae 2d postWPP    84 pupae 3d postWPP    34 pupae 4d postWPP  (961) adult male 01day  (1435) adult male 05day  (2387) adult male 30day  (1719) adult female 01day  (2251) adult female 05day  (1149) adult female 30day  (1475) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    56 embryo 04-06hr    384 embryo 06-08hr    41 embryo 08-10hr    50 embryo 10-12hr    42 embryo 12-14hr    27 embryo 14-16hr    331 embryo 16-18hr  (1669) embryo 18-20hr  (5230) embryo 20-22hr  (8203) embryo 22-24hr  (7748) larva L1  (5546) larva L2  (3375) larva L3 12hr old  (2766) larva L3 puffstage 1-2  (4634) larva L3 puffstage 3-6  (3626) larva L3 puffstage 7-9  (2474) white prepupae new    1332 white prepupae 12hr    523 white prepupae 24hr    113 pupae 2d postWPP    84 pupae 3d postWPP    34 pupae 4d postWPP    961 adult male 01day  1435 adult male 05day  (2387) adult male 30day  (1719) adult female 01day  (2251) adult female 05day    1149 adult female 30day  1475 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    56 embryo 04-06hr    384 embryo 06-08hr    41 embryo 08-10hr    50 embryo 10-12hr    42 embryo 12-14hr    27 embryo 14-16hr    331 embryo 16-18hr    1669 embryo 18-20hr    5230 embryo 20-22hr    8203 embryo 22-24hr    7748 larva L1    5546 larva L2    3375 larva L3 12hr old    2766 larva L3 puffstage 1-2    4634 larva L3 puffstage 3-6    3626 larva L3 puffstage 7-9    2474 white prepupae new    1332 white prepupae 12hr    523 white prepupae 24hr    113 pupae 2d postWPP    84 pupae 3d postWPP    34 pupae 4d postWPP    961 adult male 01day    1435 adult male 05day    2387 adult male 30day    1719 adult female 01day    2251 adult female 05day    1149 adult female 30day    1475 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    56 embryo 04-06hr    384 embryo 06-08hr    41 embryo 08-10hr    50 embryo 10-12hr    42 embryo 12-14hr    27 embryo 14-16hr    331 embryo 16-18hr    1669 embryo 18-20hr    5230 embryo 20-22hr    8203 embryo 22-24hr    7748 larva L1    5546 larva L2    3375 larva L3 12hr old    2766 larva L3 puffstage 1-2    4634 larva L3 puffstage 3-6    3626 larva L3 puffstage 7-9    2474 white prepupae new    1332 white prepupae 12hr    523 white prepupae 24hr    113 pupae 2d postWPP    84 pupae 3d postWPP    34 pupae 4d postWPP    961 adult male 01day    1435 adult male 05day    2387 adult male 30day    1719 adult female 01day    2251 adult female 05day    1149 adult female 30day    1475 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033124 expression level Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    56 embryo 04-06hr    384 embryo 06-08hr    41 embryo 08-10hr    50 embryo 10-12hr    42 embryo 12-14hr    27 embryo 14-16hr    331 embryo 16-18hr    1669 embryo 18-20hr    5230 embryo 20-22hr    8203 embryo 22-24hr    7748 larva L1    5546 larva L2    3375 larva L3 12hr old    2766 larva L3 puffstage 1-2    4634 larva L3 puffstage 3-6    3626 larva L3 puffstage 7-9    2474 white prepupae new    1332 white prepupae 12hr    523 white prepupae 24hr    113 pupae 2d postWPP    84 pupae 3d postWPP    34 pupae 4d postWPP    961 adult male 01day    1435 adult male 05day    2387 adult male 30day    1719 adult female 01day    2251 adult female 05day    1149 adult female 30day    1475 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    56 embryo 04-06hr  (384) embryo 06-08hr    41 embryo 08-10hr    50 embryo 10-12hr    42 embryo 12-14hr    27 embryo 14-16hr  (331) embryo 16-18hr  (1669) embryo 18-20hr  (5230) embryo 20-22hr  (8203) embryo 22-24hr  (7748) larva L1  (5546) larva L2  (3375) larva L3 12hr old  (2766) larva L3 puffstage 1-2  (4634) larva L3 puffstage 3-6  (3626) larva L3 puffstage 7-9  (2474) white prepupae new  (1332) white prepupae 12hr  (523) white prepupae 24hr  113 pupae 2d postWPP    84 pupae 3d postWPP    34 pupae 4d postWPP  (961) adult male 01day  (1435) adult male 05day  (2387) adult male 30day  (1719) adult female 01day  (2251) adult female 05day  (1149) adult female 30day  (1475) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    56 embryo 04-06hr    384 embryo 06-08hr    41 embryo 08-10hr    50 embryo 10-12hr    42 embryo 12-14hr    27 embryo 14-16hr    331 embryo 16-18hr  1669 embryo 18-20hr  (5230) embryo 20-22hr  (8203) embryo 22-24hr  (7748) larva L1  (5546) larva L2  (3375) larva L3 12hr old  (2766) larva L3 puffstage 1-2  (4634) larva L3 puffstage 3-6  (3626) larva L3 puffstage 7-9  (2474) white prepupae new    1332 white prepupae 12hr    523 white prepupae 24hr    113 pupae 2d postWPP    84 pupae 3d postWPP    34 pupae 4d postWPP    961 adult male 01day  1435 adult male 05day  2387 adult male 30day  1719 adult female 01day  2251 adult female 05day    1149 adult female 30day  1475 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    56 embryo 04-06hr    384 embryo 06-08hr    41 embryo 08-10hr    50 embryo 10-12hr    42 embryo 12-14hr    27 embryo 14-16hr    331 embryo 16-18hr    1669 embryo 18-20hr    5230 embryo 20-22hr    8203 embryo 22-24hr    7748 larva L1    5546 larva L2    3375 larva L3 12hr old    2766 larva L3 puffstage 1-2    4634 larva L3 puffstage 3-6    3626 larva L3 puffstage 7-9    2474 white prepupae new    1332 white prepupae 12hr    523 white prepupae 24hr    113 pupae 2d postWPP    84 pupae 3d postWPP    34 pupae 4d postWPP    961 adult male 01day    1435 adult male 05day    2387 adult male 30day    1719 adult female 01day    2251 adult female 05day    1149 adult female 30day    1475 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    56 embryo 04-06hr    384 embryo 06-08hr    41 embryo 08-10hr    50 embryo 10-12hr    42 embryo 12-14hr    27 embryo 14-16hr    331 embryo 16-18hr    1669 embryo 18-20hr    5230 embryo 20-22hr    8203 embryo 22-24hr    7748 larva L1    5546 larva L2    3375 larva L3 12hr old    2766 larva L3 puffstage 1-2    4634 larva L3 puffstage 3-6    3626 larva L3 puffstage 7-9    2474 white prepupae new    1332 white prepupae 12hr    523 white prepupae 24hr    113 pupae 2d postWPP    84 pupae 3d postWPP    34 pupae 4d postWPP    961 adult male 01day    1435 adult male 05day    2387 adult male 30day    1719 adult female 01day    2251 adult female 05day    1149 adult female 30day    1475 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033124    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033124 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033124 expression level Tissue   Expression Level Larval Central Nervous System    4.825 Larval Midgut    2643.7 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    7.3 Larval Trachea    9.925 Larval Carcass    8.475 Adult Head    7.9 Adult Eye no informative data Adult Brain    3.8 Adult Thoracic-Abdominal Ganglion    7.6 Adult Crop no informative data Adult Midgut    2352.3 Adult Hindgut no informative data Adult Malpighian Tubules    41.6 Adult Fat Body    8.5 Adult Salivary Gland no informative data Adult Heart    6.3 Adult VirginFemale Spermatheca    6 Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    1.7 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    9.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.825 Larval Midgut  (2643.7) Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    7.3 Larval Trachea    9.925 Larval Carcass    8.475 Adult Head    7.9 Adult Eye no informative data Adult Brain    3.8 Adult Thoracic-Abdominal Ganglion    7.6 Adult Crop no informative data Adult Midgut  (2352.3) Adult Hindgut no informative data Adult Malpighian Tubules    41.6 Adult Fat Body    8.5 Adult Salivary Gland no informative data Adult Heart    6.3 Adult VirginFemale Spermatheca    6 Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    1.7 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    9.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.825 Larval Midgut  (2643.7) Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    7.3 Larval Trachea    9.925 Larval Carcass    8.475 Adult Head    7.9 Adult Eye no informative data Adult Brain    3.8 Adult Thoracic-Abdominal Ganglion    7.6 Adult Crop no informative data Adult Midgut  (2352.3) Adult Hindgut no informative data Adult Malpighian Tubules    41.6 Adult Fat Body    8.5 Adult Salivary Gland no informative data Adult Heart    6.3 Adult VirginFemale Spermatheca    6 Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    1.7 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    9.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.825 Larval Midgut    2643.7 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    7.3 Larval Trachea    9.925 Larval Carcass    8.475 Adult Head    7.9 Adult Eye no informative data Adult Brain    3.8 Adult Thoracic-Abdominal Ganglion    7.6 Adult Crop no informative data Adult Midgut    2352.3 Adult Hindgut no informative data Adult Malpighian Tubules    41.6 Adult Fat Body    8.5 Adult Salivary Gland no informative data Adult Heart    6.3 Adult VirginFemale Spermatheca    6 Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    1.7 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    9.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033124 expression level Tissue   Expression Level Larval Central Nervous System    4.825 Larval Midgut    2643.7 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    7.3 Larval Trachea    9.925 Larval Carcass    8.475 Adult Head    7.9 Adult Eye no informative data Adult Brain    3.8 Adult Thoracic-Abdominal Ganglion    7.6 Adult Crop no informative data Adult Midgut    2352.3 Adult Hindgut no informative data Adult Malpighian Tubules    41.6 Adult Fat Body    8.5 Adult Salivary Gland no informative data Adult Heart    6.3 Adult VirginFemale Spermatheca    6 Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    1.7 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    9.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.825 Larval Midgut  (2643.7) Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    7.3 Larval Trachea    9.925 Larval Carcass    8.475 Adult Head    7.9 Adult Eye no informative data Adult Brain    3.8 Adult Thoracic-Abdominal Ganglion    7.6 Adult Crop no informative data Adult Midgut  (2352.3) Adult Hindgut no informative data Adult Malpighian Tubules    41.6 Adult Fat Body    8.5 Adult Salivary Gland no informative data Adult Heart    6.3 Adult VirginFemale Spermatheca    6 Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    1.7 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    9.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.825 Larval Midgut  (2643.7) Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    7.3 Larval Trachea    9.925 Larval Carcass    8.475 Adult Head    7.9 Adult Eye no informative data Adult Brain    3.8 Adult Thoracic-Abdominal Ganglion    7.6 Adult Crop no informative data Adult Midgut  (2352.3) Adult Hindgut no informative data Adult Malpighian Tubules    41.6 Adult Fat Body    8.5 Adult Salivary Gland no informative data Adult Heart    6.3 Adult VirginFemale Spermatheca    6 Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    1.7 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    9.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.825 Larval Midgut    2643.7 Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    7.3 Larval Trachea    9.925 Larval Carcass    8.475 Adult Head    7.9 Adult Eye no informative data Adult Brain    3.8 Adult Thoracic-Abdominal Ganglion    7.6 Adult Crop no informative data Adult Midgut    2352.3 Adult Hindgut no informative data Adult Malpighian Tubules    41.6 Adult Fat Body    8.5 Adult Salivary Gland no informative data Adult Heart    6.3 Adult VirginFemale Spermatheca    6 Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    1.7 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    9.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    7.9   NA  Eye    no informative data   NA  Brain    3.8   4.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    7.6   NA  Crop    no informative data   2643.7  Midgut    2352.3   no informative data  Hindgut    no informative data   no informative data  Malpighian Tubules    41.6   no informative data  Fat Body    8.5   7.3  Salivary Gland    no informative data   NA  Heart    6.3   9.925  Trachea    NA   NA  VirginFemale Spermatheca    6   NA  InseminatedFemale Spermatheca    9.9   NA  Ovary    1.7   NA  Testis    5.1   NA  Male Accessory Gland    no informative data   8.475  Carcass    9.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033124 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12847-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Tsp42Ec Stages(s) 1-3 Stages(s) 4-6 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Tsp42EcGD1839 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Tsp42Ec Class Mutagen Stocks Known lesion Tsp42EcMB06423 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tsp42Ec Class Mutagen Stocks Known lesion Tsp42EcGD1839 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Δ42E (Lin et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1839} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Tsp42EcMB06423 No
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
	There is no information supporting a biological process or molecular function term for this gene. (Based on a review of available data on: 2011-06-30)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR000301, InterPro:IPR008952, InterPro:IPR018499 (FlyBase Curators et al., 2004-) inferred from sequence model (Fradkin et al., 2002) inferred from sequence or structural similarity (Todres et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tsp42Ec allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61501 DroID - A comprehensive database of gene and protein interactions. • FBgn0033124 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35612
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12680 Dere\GG23242 Dgri\GH21497 Dmoj\GI19466 Dper\GL11135 Dpse\GA11852 Dsec\GM20914 Dsim\GD10443 Dvir\GJ15126 Dwil\GK21773 Dyak\GE19092
Curated drosophilid orthologs	Dpse\GA11852
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0236453 FBgn0223758 FBgn0202323 FBgn0182214 FBgn0175795 FBgn0071901 FBgn0148745 FBgn0142204 FBgn0128959 FBgn0115393 FBgn0089714
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	25620 w1118; Mi{ET1}Tsp42EcMB06423
VDRC	v37149 w1118; P{GD1839}v37149 v37150 w1118; P{GD1839}v37150 v43534 w1118; P{GD1839}v43534
Genomic Clones ( 2 )
	BACR29G01 BACR36G11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 47 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP02831
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	41692 70578 83397 121933 156971 193015 214307.28 214411.41 Dmel_dig_005463_0642_2214 EC00551 EC01551 EK197616 EK217662 EK242054 EK259751 EK296230 EP01540 EP08754 RP004017220 RP004081890 RP004108218 RP004108807 RP004187069 RP004196772 RP004202347 RP004203341 RP004211847 RP004222238 RP004222837 RP004226546 RP004239780 RP004240702 RP004241945 RP004244280 RP004256620 RP004260945 RP004264041 RP004346827 RP004385100 RP004429010 RP004431091 RP004438449 RP004515082 RP004529660 RP004550651 RP004557379
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033124 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35612
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tsp42Ec CG12847 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Tsp42Ec CG12847 was sequence comparison (date:000815). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078905 RefSeq (Proteins) • NP_523629 DDBJ / EMBL / GenBank • AAF59313 AAF90142 AAM50855 AF274016 AI259420 AY118995 Entrez Gene - A searchable database of RefSeq genes. • 35612 UniProtKB/TrEMBL • Q9NB13
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tetraspanin (IPR018499) Tetraspanin, subgroup (IPR000301) Tetraspanin, EC2 domain (IPR008952)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61501 DroID - A comprehensive database of gene and protein interactions. • FBgn0033124 DRSC - Results from RNAi screens. • FBgn0033124 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033124 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12847-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033124 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35612 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35612 modMine - Data generated by the modENCODE project. • FBgn0033124 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0236453 FBgn0223758 FBgn0202323 FBgn0182214 FBgn0175795 FBgn0071901 FBgn0148745 FBgn0142204 FBgn0128959 FBgn0115393 FBgn0089714
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG12847 (Fradkin et al., 2002, Todres et al., 2000, Riedl et al., 2005) Dm.Tsp42Ec (Todres et al., 2000) Tsp42Ec (Yamamoto et al., 2009.2.25, Riedl et al., 2005)
Name Synonym	tetraspanin 42E (Silverman et al., 2003) Tetraspanin 42Ec (Todres, 2000.6.1)
Secondary FlyBase IDs
References ( 19 )
Research paper	Lin et al., 2005, Proc. Natl. Acad. Sci. USA 102(36): 12831--12836 A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. [FBrf0188263] Riedl et al., 2005, Behav. Genet. 35(3): 231--244 Drosophila soluble guanylyl cyclase mutants exhibit increased foraging locomotion: behavioral and genomic investigations. [FBrf0187131] Vodovar et al., 2005, Proc. Natl. Acad. Sci. USA 102(32): 11414--11419 Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species. [FBrf0188279] Silverman et al., 2003, J. Biol. Chem. 278(49): 48928--48934 Immune activation of NF-kappaB and JNK requires Drosophila TAK1. [FBrf0167753] Fradkin et al., 2002, Proc. Natl. Acad. Sci. USA 99(21): 13663--13668 Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. [FBrf0152316] Todres et al., 2000, Insect Molec. Biol. 9(6): 581--590 The tetraspanin superfamily in insects. [FBrf0132356]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Yamamoto et al., 2009.2.25, Microarray analysis of Df(2R)nap9. Microarray analysis of Df(2R)nap9. [FBrf0207893] Bellen, 2008.9.12, set814.xml set814.xml [FBrf0205645] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Robertson, 2000.4.13, FlyBase error report for CG12847 on Thu Apr 13 09:46:55 2000. FlyBase error report for CG12847 on Thu Apr 13 09:46:55 2000. [FBrf0128949]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
DNA/RNA sequence record	Todres, 2000.6.1, GenBank/EMBL/DDBJ: AF274016 Drosophila melanogaster tetraspanin 42Ec mRNA, complete cds. [FBrf0130967]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]