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Gene Dmel\Gadd45

General Information
Symbol	Dmel\Gadd45	Species	D. melanogaster
Name	Gadd45	Annotation symbol	CG11086
Feature type	protein_coding_gene	FlyBase ID	FBgn0033153
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	D-GADD45
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	43A2-43A2	Sequence location	2R:3,136,668..3,138,160 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Gadd45 is referred to in FlyBase by the symbol Dmel\Gadd45 (CG11086, FBgn0033153). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: JNK cascade; regulation of oviposition. 5 alleles are reported. The phenotypes of these alleles are annotated with: chorion; follicle cell; egg chamber; dorsal appendage; nurse cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Ribosomal protein L7Ae/L30e/S12e/Gadd45. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1625139_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Gadd45. Gene sequence location is 2R:3136668..3138160.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN25210 HFA06033
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 43A2-43A2   Limits computationally determined from genome sequence between P{lacW}vimark16722 and P{lacW}cosk16101
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gadd45 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gadd45-RA FBtr0089049  NM_136420   1493   163
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gadd45-PA   FBpp0088120   18.1   163   4.22     NP_610264   AAF59278
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L7Ae/L30e/S12e/Gadd45 (IPR004038)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF59278   AY113626 AAM29631   BI213100   BI237299   BI241174   BI241311   BI587732   BI588392   BI605225   BI608927   BI635397   BI641768   BT088861   CA804121   CA804384   CO154119   CO332032   EC205229   EC260934   GH738969   GH741396   GH742180   GH742514   GH742544   GH742852   GH743896   GH744002   GH744708   GH745023   GH746849   GH762492   GH763220   GH765001   GH765426   GH765929   GH766052   GH767876   GH767942   GH768952   GH769556   GH769792
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MYS8 A1Z6W5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033153    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033153 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033153 expression level Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    22 embryo 08-10hr    70 embryo 10-12hr    768 embryo 12-14hr    651 embryo 14-16hr    407 embryo 16-18hr    802 embryo 18-20hr    1142 embryo 20-22hr    730 embryo 22-24hr    788 larva L1    408 larva L2    578 larva L3 12hr old    406 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    647 larva L3 puffstage 7-9    1335 white prepupae new    2211 white prepupae 12hr    2618 white prepupae 24hr    1107 pupae 2d postWPP    1116 pupae 3d postWPP    571 pupae 4d postWPP    5207 adult male 01day    449 adult male 05day    496 adult male 30day    575 adult female 01day    503 adult female 05day    356 adult female 30day    431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    22 embryo 08-10hr    70 embryo 10-12hr  (768) embryo 12-14hr  (651) embryo 14-16hr  (407) embryo 16-18hr  (802) embryo 18-20hr  (1142) embryo 20-22hr  (730) embryo 22-24hr  (788) larva L1  (408) larva L2  (578) larva L3 12hr old  (406) larva L3 puffstage 1-2  (403) larva L3 puffstage 3-6  (647) larva L3 puffstage 7-9  (1335) white prepupae new  (2211) white prepupae 12hr  (2618) white prepupae 24hr  (1107) pupae 2d postWPP  (1116) pupae 3d postWPP  (571) pupae 4d postWPP  (5207) adult male 01day  (449) adult male 05day  (496) adult male 30day  (575) adult female 01day  (503) adult female 05day  (356) adult female 30day  (431) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    22 embryo 08-10hr    70 embryo 10-12hr    768 embryo 12-14hr    651 embryo 14-16hr    407 embryo 16-18hr    802 embryo 18-20hr    1142 embryo 20-22hr    730 embryo 22-24hr    788 larva L1    408 larva L2    578 larva L3 12hr old    406 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    647 larva L3 puffstage 7-9    1335 white prepupae new  (2211) white prepupae 12hr  (2618) white prepupae 24hr    1107 pupae 2d postWPP    1116 pupae 3d postWPP    571 pupae 4d postWPP  (5207) adult male 01day    449 adult male 05day    496 adult male 30day    575 adult female 01day    503 adult female 05day    356 adult female 30day    431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    22 embryo 08-10hr    70 embryo 10-12hr    768 embryo 12-14hr    651 embryo 14-16hr    407 embryo 16-18hr    802 embryo 18-20hr    1142 embryo 20-22hr    730 embryo 22-24hr    788 larva L1    408 larva L2    578 larva L3 12hr old    406 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    647 larva L3 puffstage 7-9    1335 white prepupae new    2211 white prepupae 12hr    2618 white prepupae 24hr    1107 pupae 2d postWPP    1116 pupae 3d postWPP    571 pupae 4d postWPP    5207 adult male 01day    449 adult male 05day    496 adult male 30day    575 adult female 01day    503 adult female 05day    356 adult female 30day    431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    22 embryo 08-10hr    70 embryo 10-12hr    768 embryo 12-14hr    651 embryo 14-16hr    407 embryo 16-18hr    802 embryo 18-20hr    1142 embryo 20-22hr    730 embryo 22-24hr    788 larva L1    408 larva L2    578 larva L3 12hr old    406 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    647 larva L3 puffstage 7-9    1335 white prepupae new    2211 white prepupae 12hr    2618 white prepupae 24hr    1107 pupae 2d postWPP    1116 pupae 3d postWPP    571 pupae 4d postWPP    5207 adult male 01day    449 adult male 05day    496 adult male 30day    575 adult female 01day    503 adult female 05day    356 adult female 30day    431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033153 expression level Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    22 embryo 08-10hr    70 embryo 10-12hr    768 embryo 12-14hr    651 embryo 14-16hr    407 embryo 16-18hr    802 embryo 18-20hr    1142 embryo 20-22hr    730 embryo 22-24hr    788 larva L1    408 larva L2    578 larva L3 12hr old    406 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    647 larva L3 puffstage 7-9    1335 white prepupae new    2211 white prepupae 12hr    2618 white prepupae 24hr    1107 pupae 2d postWPP    1116 pupae 3d postWPP    571 pupae 4d postWPP    5207 adult male 01day    449 adult male 05day    496 adult male 30day    575 adult female 01day    503 adult female 05day    356 adult female 30day    431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    22 embryo 08-10hr    70 embryo 10-12hr  (768) embryo 12-14hr  (651) embryo 14-16hr  (407) embryo 16-18hr  (802) embryo 18-20hr  (1142) embryo 20-22hr  (730) embryo 22-24hr  (788) larva L1  (408) larva L2  (578) larva L3 12hr old  (406) larva L3 puffstage 1-2  (403) larva L3 puffstage 3-6  (647) larva L3 puffstage 7-9  (1335) white prepupae new  (2211) white prepupae 12hr  (2618) white prepupae 24hr  (1107) pupae 2d postWPP  (1116) pupae 3d postWPP  (571) pupae 4d postWPP  (5207) adult male 01day  (449) adult male 05day  (496) adult male 30day  (575) adult female 01day  (503) adult female 05day  (356) adult female 30day  (431) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    22 embryo 08-10hr    70 embryo 10-12hr    768 embryo 12-14hr    651 embryo 14-16hr    407 embryo 16-18hr    802 embryo 18-20hr    1142 embryo 20-22hr    730 embryo 22-24hr    788 larva L1    408 larva L2    578 larva L3 12hr old    406 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    647 larva L3 puffstage 7-9    1335 white prepupae new  2211 white prepupae 12hr  (2618) white prepupae 24hr    1107 pupae 2d postWPP    1116 pupae 3d postWPP    571 pupae 4d postWPP  (5207) adult male 01day    449 adult male 05day    496 adult male 30day    575 adult female 01day    503 adult female 05day    356 adult female 30day    431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    22 embryo 08-10hr    70 embryo 10-12hr    768 embryo 12-14hr    651 embryo 14-16hr    407 embryo 16-18hr    802 embryo 18-20hr    1142 embryo 20-22hr    730 embryo 22-24hr    788 larva L1    408 larva L2    578 larva L3 12hr old    406 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    647 larva L3 puffstage 7-9    1335 white prepupae new    2211 white prepupae 12hr    2618 white prepupae 24hr    1107 pupae 2d postWPP    1116 pupae 3d postWPP    571 pupae 4d postWPP    5207 adult male 01day    449 adult male 05day    496 adult male 30day    575 adult female 01day    503 adult female 05day    356 adult female 30day    431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    22 embryo 08-10hr    70 embryo 10-12hr    768 embryo 12-14hr    651 embryo 14-16hr    407 embryo 16-18hr    802 embryo 18-20hr    1142 embryo 20-22hr    730 embryo 22-24hr    788 larva L1    408 larva L2    578 larva L3 12hr old    406 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    647 larva L3 puffstage 7-9    1335 white prepupae new    2211 white prepupae 12hr    2618 white prepupae 24hr    1107 pupae 2d postWPP    1116 pupae 3d postWPP    571 pupae 4d postWPP    5207 adult male 01day    449 adult male 05day    496 adult male 30day    575 adult female 01day    503 adult female 05day    356 adult female 30day    431 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033153    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033153 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033153 expression level Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut no informative data Larval Hindgut    55.7 Larval Malpighian Tubules    112.5 Larval Fat Body    52.4 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    60.95 Adult Head no informative data Adult Eye no informative data Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    83.3 Adult Malpighian Tubules no informative data Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    81.375 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4 Adult Ovary no informative data Adult Testis    8.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut no informative data Larval Hindgut    55.7 Larval Malpighian Tubules    112.5 Larval Fat Body    52.4 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    60.95 Adult Head no informative data Adult Eye no informative data Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    83.3 Adult Malpighian Tubules no informative data Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    81.375 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4 Adult Ovary no informative data Adult Testis    8.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut no informative data Larval Hindgut    55.7 Larval Malpighian Tubules    112.5 Larval Fat Body    52.4 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    60.95 Adult Head no informative data Adult Eye no informative data Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    83.3 Adult Malpighian Tubules no informative data Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    81.375 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4 Adult Ovary no informative data Adult Testis    8.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut no informative data Larval Hindgut    55.7 Larval Malpighian Tubules    112.5 Larval Fat Body    52.4 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    60.95 Adult Head no informative data Adult Eye no informative data Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    83.3 Adult Malpighian Tubules no informative data Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    81.375 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4 Adult Ovary no informative data Adult Testis    8.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033153 expression level Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut no informative data Larval Hindgut    55.7 Larval Malpighian Tubules    112.5 Larval Fat Body    52.4 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    60.95 Adult Head no informative data Adult Eye no informative data Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    83.3 Adult Malpighian Tubules no informative data Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    81.375 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4 Adult Ovary no informative data Adult Testis    8.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut no informative data Larval Hindgut    55.7 Larval Malpighian Tubules    112.5 Larval Fat Body    52.4 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    60.95 Adult Head no informative data Adult Eye no informative data Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    83.3 Adult Malpighian Tubules no informative data Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    81.375 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4 Adult Ovary no informative data Adult Testis    8.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut no informative data Larval Hindgut    55.7 Larval Malpighian Tubules    112.5 Larval Fat Body    52.4 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    60.95 Adult Head no informative data Adult Eye no informative data Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    83.3 Adult Malpighian Tubules no informative data Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    81.375 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4 Adult Ovary no informative data Adult Testis    8.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.175 Larval Midgut no informative data Larval Hindgut    55.7 Larval Malpighian Tubules    112.5 Larval Fat Body    52.4 Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass    60.95 Adult Head no informative data Adult Eye no informative data Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    83.3 Adult Malpighian Tubules no informative data Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    81.375 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    4 Adult Ovary no informative data Adult Testis    8.8 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass     Adult Head no informative data Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary no informative data Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    43.8   6.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    27.9   NA  Crop    no informative data   no informative data  Midgut    no informative data   55.7  Hindgut    83.3   112.5  Malpighian Tubules    no informative data   52.4  Fat Body    8.6   no informative data  Salivary Gland    no informative data   NA  Heart    81.375   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    2.4   NA  InseminatedFemale Spermatheca    4   NA  Ovary    no informative data   NA  Testis    8.8   NA  Male Accessory Gland    no informative data   60.95  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_18
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033153 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11086-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PU Gadd45Scer\UAS.P\T.cPa lethal, with Scer\GAL4tub.PU Gadd45Scer\UAS.P\T.cPa viable, with Scer\GAL4pnr-MD237 Gadd45GD7193 Other Phenotypes Allele locomotor rhythm defective, with Scer\GAL41407 Gadd45Scer\UAS.P\T.cPa locomotor rhythm defective | RU486 conditional, with Scer\GAL4elav.Switch.PO Gadd45Scer\UAS.P\T.cPa long lived, with Scer\GAL41407 Gadd45Scer\UAS.P\T.cPa long lived | RU486 conditional, with Scer\GAL4elav.Switch.PO Gadd45Scer\UAS.P\T.cPa Phenotype manifest in Allele chorion, with Scer\GAL4nos.UTR.T:Hsim\VP16 Gadd45Scer\UAS.P\T.cPa dorsal appendage, with Scer\GAL4nos.UTR.T:Hsim\VP16 Gadd45Scer\UAS.P\T.cPa egg chamber, with Scer\GAL4CY2 Gadd45Scer\UAS.P\T.cPa follicle cell, with Scer\GAL4CY2 Gadd45Scer\UAS.P\T.cPa nurse cell, with Scer\GAL4CY2 Gadd45Scer\UAS.P\T.cPa
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Gadd45 Class Mutagen Stocks Known lesion Gadd45NP0351 2 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gadd45 Class Mutagen Stocks Known lesion Gadd45GD7193 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Gadd45HMS01436 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gadd45KK104250 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gadd45Scer\UAS.P\T.cPa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7193} NA P{KK104250} NA P{TRiP.HMS01436} NA P{UASp-Gadd45.P} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}Gadd45NP0351 No miscellaneous insertions P{SUPor-P}KG01674 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
JNK cascade inferred from genetic interaction with hep (Peretz et al., 2007) regulation of oviposition inferred from mutant phenotype (Plyusnina et al., 2011)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Peretz et al., 2007)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gadd45 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61528 DroID - A comprehensive database of gene and protein interactions. • FBgn0033153 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35646
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12703 Dere\GG23269 Dgri\GH21525 Dmoj\GI19497 Dper\GL11158 Dpse\GA10750 Dsec\GM20942 Dsim\GD15338 Dvir\GJ21062 Dwil\GK21796 Dyak\GE19117
Curated drosophilid orthologs	Dpse\GA10750
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006883-PA Aedes aegypti (mosquito) AGAP007651-PA Anopheles gambiae (mosquito) BGIBMGA013938-PA Bombyx mori (silk worm) ENSBTAP00000003943 Bos taurus (bovine) ENSCAFP00000003178 Canis familiaris (dog) CPIJ012801 Culex pipens (mosquito) ENSCPOP00000005239 Cavia porcellus (guinea pig) 207799 Capitella spl (polychaete worm) ENSDARP00000065648 Danio rerio (zebra fish) ENSECAP00000020922 Equus caballus (horse) ENSGACP00000023707 Gymnopilus aculeatus (mushroom) ENSP00000252506 Homo sapiens (human) 227883 Lottia gigantea (owl limpet) ENSMODP00000001469 Monodelphis domestica (gray opossum) ENSMMUP00000008955 Macaca mulatta (rhesus monkey) ENSMUSP00000021903 Mus musculus (house mouse) 248405 Nematostella vectensis (starlet anemone) ENSOANP00000012371 Ornithorynchus anatinus (platypus) ENSORLP00000018482 Oryzias latipes (japanese killifish) ENSPPYP00000021697 Pongo pygmaeus (orangutan) ENSPTRP00000036056 Pan troglodytes (chimpanzee) ENSRNOP00000018251 Rattus norvegicus (norway rat) XP_975522.1 Tribolium castaneum (red flour beetle) ENSTNIP00000019775 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000032612 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000055911 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV30286 LH20955 FBgn0236477 FBgn0223781 FBgn0208196 FBgn0187006 FBgn0175823 FBgn0070806 FBgn0148768 FBgn0142235 FBgn0128987 FBgn0115420 FBgn0089737 CPIJ012801 BGIBMGA013938 AGAP007650 AGAP007651 AAEL006886 AAEL006883 GLEAN_08827
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	35023 y1 sc* v1; P{TRiP.HMS01436}attP2
Kyoto	103594 y* w*; P{GawB}Gadd45NP0351 / CyO, P{UAS-lacZ.UW14}UW14 112149 y* w*; P{GawB}Gadd45NP0351 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v100413 P{KK104250}VIE-260B v18690 w1118; P{GD7193}v18690 v18691 w1118; P{GD7193}v18691/TM3
Genomic Clones ( 1 )
	BACR26B18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 39 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH70774
Other clones	FI09246
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE18426 RE33508 RE38191 RE38345 RH13647 RH28594 RH29589 SD16739 SD25377
Other clones	274677 523159 EK302342 EN03528 ESG0112a.B21.1_H03 ESG0113b.B21.1_F06 RP001005005 RP001005010 RP001005513 RP001007616 RP001009054 RP001011216 RP001016343 RP001017682 RP001021716 RP001024547 RP001025157 RP001026019 RP001029956 RP001033338 RP001038306 RP001038931 RP001040347 RP001042710 RP001044569 RP001046264 RP001050774 RP001050826
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033153 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35646
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Gadd45 CG11086 (Shotts and Abdu, 2006)
Source for database merge of	Source for merge of: CG11086 BcDNA:RH70774 (FlyBase, 1996-)
Additional comments	Source for merge of CG11086 BcDNA:RH70774 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136420 RefSeq (Proteins) • NP_610264 DDBJ / EMBL / GenBank • AAF59278 AAM29631 AY113626 BI605225 Entrez Gene - A searchable database of RefSeq genes. • 35646 UniProtKB/TrEMBL • A1Z6W5 Q8MYS8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L7Ae/L30e/S12e/Gadd45 (IPR004038)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61528 DroID - A comprehensive database of gene and protein interactions. • FBgn0033153 DRSC - Results from RNAi screens. • FBgn0033153 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033153 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11086-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033153 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35646 InParanoid A subset of ortholog calls from InParanoid. • AAEL006883-PA Aedes aegypti (mosquito) AGAP007651-PA Anopheles gambiae (mosquito) BGIBMGA013938-PA Bombyx mori (silk worm) ENSBTAP00000003943 Bos taurus (bovine) ENSCAFP00000003178 Canis familiaris (dog) CPIJ012801 Culex pipens (mosquito) ENSCPOP00000005239 Cavia porcellus (guinea pig) 207799 Capitella spl (polychaete worm) ENSDARP00000065648 Danio rerio (zebra fish) ENSECAP00000020922 Equus caballus (horse) ENSGACP00000023707 Gymnopilus aculeatus (mushroom) ENSP00000252506 Homo sapiens (human) 227883 Lottia gigantea (owl limpet) ENSMODP00000001469 Monodelphis domestica (gray opossum) ENSMMUP00000008955 Macaca mulatta (rhesus monkey) ENSMUSP00000021903 Mus musculus (house mouse) 248405 Nematostella vectensis (starlet anemone) ENSOANP00000012371 Ornithorynchus anatinus (platypus) ENSORLP00000018482 Oryzias latipes (japanese killifish) ENSPPYP00000021697 Pongo pygmaeus (orangutan) ENSPTRP00000036056 Pan troglodytes (chimpanzee) ENSRNOP00000018251 Rattus norvegicus (norway rat) XP_975522.1 Tribolium castaneum (red flour beetle) ENSTNIP00000019775 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000032612 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000055911 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/gadd45.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35646 modMine - Data generated by the modENCODE project. • FBgn0033153 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV30286 LH20955 FBgn0236477 FBgn0223781 FBgn0208196 FBgn0187006 FBgn0175823 FBgn0070806 FBgn0148768 FBgn0142235 FBgn0128987 FBgn0115420 FBgn0089737 CPIJ012801 BGIBMGA013938 AGAP007650 AGAP007651 AAEL006886 AAEL006883 GLEAN_08827
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	BcDNA:RH70774   CG11086 (Markstein et al., 2002, De Gregorio et al., 2002, FlyBase, 1996-, Shotts and Abdu, 2006, Peretz and Abdu, 2007, Weake et al., 2008, Kadener et al., 2007, Peretz et al., 2007, Brandt et al., 2008, Stramer et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) D-GADD45 (Peretz and Abdu, 2007, Peretz et al., 2007) GADD45 (Shotts and Abdu, 2006, Stramer et al., 2008, Plyusnina et al., 2011) Gadd45 (Blanco et al., 2010, Buchon et al., 2009) GG1086 (Plyusnina et al., 2011)
Name Synonym	Gadd45   growth arrest and DNA damage-inducible gene 45 (Stramer et al., 2008)
Secondary FlyBase IDs
	FBgn0062909
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Plyusnina et al., 2011, Biogerontology 12(3): 211--226 Increase of Drosophila melanogaster lifespan due to D-GADD45 overexpression in the nervous system. [FBrf0213783] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...