Dscam, Down syndrome cell adhesion molecule, l(2)43Bc, Drosophila Down syndrome cell adhesion molecule, Neu1
95 alternative exons are arranged in four clusters.The exon 4, 6, 9, and 17 clusters contain 12, 48, 33, and 2 variable exons, respectively. The exons within each cluster are alternatively spliced in a mutually exclusive manner such that Dscam mRNAs contain only one variable exon from each cluster.
Dscam can potentially encode 38,016 different mRNAs by virtue of alternative splicing. The Dscam gene contains 115 exons, 20 of which are constitutively spliced and 95 of which are alternatively spliced FBrf0139679
Annotated transcripts do not represent all possible combinations of alternative exons.
All variable Dscam exons from GB:AF260530 have been annotated in at least one transcript. Where possible, they have been annotated in a combination found in an mRNA characterized in FBrf0128634 or FBrf0156018. Remaining variable exons 6.11, 6.17, 6.29, 6.31, 6.38, 6.40, 6.41, 9.10, 9.28, and 9.29 have been arbitrarily joined with other variable exons.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Variant in sequenced strain: frameshift at 2R:7342645 affects one of the 33 alternative exons for exon 9.
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dscam1 using the Feature Mapper tool.
Isoform-specific expression patterns are observed. Alternative exon 4 variants of Dscam1 are expressed at different frequencies in the mushroom body. In class IV dendritic arborizing neurons, the splicing of Dscam1 exon 4 is probabilistic, not deterministic. The frequency of inclusion of particular exon 4 variants is different between cell types, and changes over time.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Dscam1 in GBrowse 2