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FB2021_04, released August 17, 2021

Gene: Dmel\Nup44A

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General Information
Symbol
Dmel\Nup44A
Species
D. melanogaster
Name
Nucleoporin at 44A
Annotation Symbol
CG8722
Feature Type
protein_coding_gene
FlyBase ID
FBgn0033247
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
Nucleoporin at 44A (Nup44A) encodes a nuclear pore protein involved in TORC1 signaling, autophagy and oogenesis. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

seh1

Key Links
Genomic Location
Cytogenetic map
44A2-44A2
Sequence location
2R:7,988,462..7,991,283 [+]
Recombination map
2-58
RefSeq locus
NT_033778 REGION:7988462..7991283
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables structural molecule activity
inferred from electronic annotation with InterPro:IPR037363
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (9 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in cellular response to amino acid starvation
inferred from mutant phenotype
(assigned by UniProt )
(Bar-Peled et al., 2013)
involved_in germarium-derived egg chamber formation
inferred from mutant phenotype
(Wei et al., 2014)
involved_in negative regulation of autophagy
inferred from mutant phenotype
(Wei et al., 2014)
involved_in oogenesis
inferred from mutant phenotype
(Senger et al., 2011)
involved_in positive regulation of autophagy
inferred from mutant phenotype
(assigned by UniProt )
(Cai et al., 2016)
involved_in positive regulation of TOR signaling
inferred from mutant phenotype
(assigned by UniProt )
(Bar-Peled et al., 2013)
involved_in positive regulation of TORC1 signaling
inferred from mutant phenotype
(Wei et al., 2014)
involved_in regulation of mitotic cell cycle
inferred from mutant phenotype
(Senger et al., 2011)
NOT involved_in protein import into nucleus
inferred from mutant phenotype
(Chen and Xu, 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cellular response to amino acid starvation
inferred from biological aspect of ancestor with PANTHER:PTN000111887
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in positive regulation of TORC1 signaling
inferred from biological aspect of ancestor with PANTHER:PTN000111887
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in autolysosome
inferred from direct assay
(Wei et al., 2014)
located_in lysosome
inferred from direct assay
(Wei et al., 2014)
located_in nuclear envelope
inferred from direct assay
(Senger et al., 2011)
part_of Seh1-associated complex
inferred from direct assay
(Cai et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of GATOR2 complex
traceable author statement
(Cai et al., 2016)
part_of nuclear pore outer ring
inferred from biological aspect of ancestor with PANTHER:PTN000111811
(assigned by GO_Central )
(Gaudet et al., 2011)
part_of Seh1-associated complex
inferred from biological aspect of ancestor with PANTHER:PTN000111887
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000003068
(FlyBase Curators, 2008--)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the WD repeat SEC13 family. (Q7K2X8)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Nucleoporin at 44A (Nup44A) encodes a nuclear pore protein involved in TORC1 signaling, autophagy and oogenesis. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
NUCLEAR PORE COMPLEX -
The Nuclear Pore Complex (NPC) is a large protein complex embedded in the nuclear membrane that facilitates nucleocytoplasmic traffic. The NPC is composed of approximately 30 different proteins: the nucleoporins. The NPC displays 8-fold symmetry and each nucleoporin is present in multiple copies. From the central ring that forms the pore, filaments protrude into the cytoplasm (cytoplasmic filaments) and the nucleoplasm (nuclear basket). Many nucleoporins contain FG repeats which are thought to act as a diffusion barrier and docking sight for transport receptors (karyopherins). Export and import is controlled by the interaction of the karyopherins with localization and export sequences. (Adapted from FBrf0220062 and PMID:21495847).
GATOR2 COMPLEX -
GATOR2 is a subcomplex of the GATOR or SEA complex. It suppresses the Rag GTPase activating protein activity of the GATOR1 subcomplex, promoting TORC1 activity. (Adapted from FBrf0232362 and PMID:25934700).
Protein Function (UniProtKB)
Probable component of the nuclear pore complex (NPC) (By similarity). Involved in maintaining the localization of another nucleoporin Mtor to the nuclear envelope of early meiotic female germline cells (PubMed:21521741). It is not involved in recruiting the nucleoporins Mtor, Nup107, Nup153 and FG-containing nucleoporins to the NPC (PubMed:21521741). An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:27166823, PubMed:23723238). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:27166823, PubMed:23723238, PubMed:25512509). GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation growth under nutrient replete conditions and growth during female oocyte development (PubMed:21521741, PubMed:25512509, PubMed:23723238, PubMed:27166823). This component is required for activating TORC1 specifically in germline cells to promote cell growth and maintain the oocyte fate, probably influences the organization and/or function of microtubules within ovarian cysts, and promotes accumulation of another GATOR2 complex member mio in germline and somatic tissues (PubMed:27166823, PubMed:23723238, PubMed:25512509, PubMed:21521741). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:21521741, PubMed:25512509). In addition to its role in the regulation of the TORC1 complex, functions independently of TORC1 to prevent the inappropriate accumulation of autolysosomes in germline tissues (PubMed:27166823).
(UniProt, Q7K2X8)
Summary (Interactive Fly)

component of a nucleoporin subcomplex - a binding parter of Missing oocyte; regulates nuclear architecture and meiotic progression in early ovarian cysts

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Nup44A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Nup44A-RA
FBtr0088862
NM_136499
1208
354
Nup44A-RB
FBtr0088860
NM_165582
1283
354
Nup44A-RC
FBtr0088861
NM_165583
1331
354
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Nup44A-PA
FBpp0087938
39.5
354
6.70
NP_610343
AAF59154
Nup44A-PB
FBpp0087936
39.5
354
6.70
NP_724637
AAM68880
Nup44A-PC
FBpp0087937
39.5
354
6.70
NP_724638
AAM68881
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

354 aa isoforms: Nup44A-PA, Nup44A-PB, Nup44A-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Probable component of the nuclear pore complex (NPC) (By similarity). Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR2 subcomplex which is likely composed of mio, Nup44A/Seh1, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Interacts with mio (PubMed:21521741). Interacts with Wdr24 (PubMed:27166823).

(UniProt, Q7K2X8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nup44A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis
nurse cell
(Senger et al., 2011)
oocyte
(Senger et al., 2011)
ovariole
(Senger et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in autolysosome
inferred from direct assay
(Wei et al., 2014)
located_in lysosome
inferred from direct assay
(Wei et al., 2014)
located_in nuclear envelope
inferred from direct assay
(Senger et al., 2011)
part_of Seh1-associated complex
inferred from direct assay
(Cai et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Nup44A in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Nup44A
Transgenic constructs containing regulatory region of Nup44A
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel6055
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SEH1L
14 of 15
Yes
Yes
Hsap\SEC13
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Seh1l
14 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Seh1l
3 of 13
Yes
Yes
Rnor\Sec13
1 of 13
No
No
Rnor\Tmsb10
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\seh1l
13 of 12
Yes
Yes
Xtro\sec13
1 of 12
No
No
Danio rerio (Zebrafish) (2)
Drer\seh1l
14 of 15
Yes
Yes
Drer\sec13
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\npp-18
13 of 15
Yes
Yes
Cele\npp-20
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (3)
Atha\SEH1H
3 of 9
Yes
Yes
Atha\AT2G30050
1 of 9
No
No
Atha\AT3G01340
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SEH1
13 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\seh1
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190ACY )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006690
Drosophila simulans
Dsim\GD10530
Drosophila sechellia
Dsec\GM20999
Drosophila erecta
Dere\GG23322
Drosophila yakuba
Dyak\GE19167
Drosophila ananassae
Dana\GF13653
Drosophila pseudoobscura pseudoobscura
Dpse\GA21281
Drosophila persimilis
Dper\GL11480
Drosophila willistoni
Dwil\GK21742
Drosophila virilis
Dvir\GJ22120
Drosophila mojavensis
Dmoj\GI20394
Drosophila grimshawi
Dgri\GH21895
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915052E )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018332
Glossina morsitans
Tsetse fly
Gmor\GMOY003952
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03827
Mayetiola destructor
Hessian fly
Mdes\Mdes005984
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006311
Anopheles darlingi
American malaria mosquito
Adar\ADAC007632
Anopheles gambiae
Malaria mosquito
Agam\AGAP005174
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005525
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W053Q )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004202
Bombyx mori
Silkmoth
Bmor\BGIBMGA001967
Danaus plexippus
Monarch butterfly
Dple\DPOGS202879-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210460-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014580
Heliconius melpomene
Postman butterfly
Hmel\HMEL004164
Apis florea
Little honeybee
Aflo\2389893780
Apis florea
Little honeybee
Aflo\2280869620
Apis mellifera
Western honey bee
Amel\GB46714
Apis mellifera
Western honey bee
Amel\GB44792
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18203
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23051
Bombus terrestris
Buff-tailed bumblebee
Bter\15216297
Bombus terrestris
Buff-tailed bumblebee
Bter\15214124
Linepithema humile
Argentine ant
Lhum\LH21088
Linepithema humile
Argentine ant
Lhum\LH18574
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000cad
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00237f
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018235
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003069
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02208
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09502
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05369
Tribolium castaneum
Red flour beetle
Tcas\TC008957
Tribolium castaneum
Red flour beetle
Tcas\TC009902
Pediculus humanus
Human body louse
Phum\PHUM309530
Pediculus humanus
Human body louse
Phum\PHUM200070
Rhodnius prolixus
Kissing bug
Rpro\RPRC007713
Rhodnius prolixus
Kissing bug
Rpro\RPRC005795
Cimex lectularius
Bed bug
Clec\CLEC009380
Cimex lectularius
Bed bug
Clec\CLEC003479
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006367
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003680
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04180
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04652
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0500 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR000871
Strigamia maritima
European centipede
Smar\SMAR009867
Ixodes scapularis
Black-legged tick
Isca\ISCW011273
Ixodes scapularis
Black-legged tick
Isca\ISCW002741
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76932.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77554.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09610
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_301745
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09MA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slob
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_009327gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Seh1L
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006008
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009345
Gallus gallus
Domestic chicken
Ggal\SEH1L
Gallus gallus
Domestic chicken
Ggal\PXK
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Sec13
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SEH1L; SEH1 like nucleoporin
    14 of 15
    609263
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Nup44A
        enhanceable
        mio
        (Senger et al., 2011)
        Nup44A
        suppressible
        Nprl2
        (Wei et al., 2014)
        Nup44A
        suppressible
        Nprl3
        (Wei et al., 2014)
        Nup44A
        suppressible
        Tsc1
        (Wei et al., 2014)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        mio
        suppressible
        Nup44A
        (Senger et al., 2011)
        External Data
        Subunit Structure (UniProtKB)
        Probable component of the nuclear pore complex (NPC) (By similarity). Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR2 subcomplex which is likely composed of mio, Nup44A/Seh1, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Interacts with mio (PubMed:21521741). Interacts with Wdr24 (PubMed:27166823).
        (UniProt, Q7K2X8 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-58
        Cytogenetic map
        44A2-44A2
        Sequence location
        2R:7,988,462..7,991,283 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        44A2-44A2
        Limits computationally determined from genome sequence between P{lacW}CSN4k08018&P{lacW}l(2)k08504k08504 and P{lacW}Vps28k16503
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-58

        (FlyBase, 2016)

        2-57.2

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (9)
        Genomic Clones (10)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (30)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: nup44A CG8722

          (Fernandez-Funez et al., 2000)
          Source for database merge of
          Additional comments

          FlyBase Curator comment: Correspondence with author Lan Xu revealed that 'seh1' = CG8722.

          (Chen and Xu, 2010)
          Other Comments
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 56 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DRscDB
          EMBL-EBI Single Cell Expression Atlas
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL
          modMine - A data warehouse for the modENCODE project
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Linkouts
          ApoDroso - Functional genomic database for photoreceptor development, survival and function
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (12)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (68)