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Gene Dmel\Cul-4

General Information
Symbol	Dmel\Cul-4	Species	D. melanogaster
Name	Cullin-4	Annotation symbol	CG8711
Feature type	protein_coding_gene	FlyBase ID	FBgn0033260
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	CUL4, Cul-4
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	44A4-44A4	Sequence location	2R:3,989,765..3,993,819 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cullin-4 is referred to in FlyBase by the symbol Dmel\Cul-4 (CG8711, FBgn0033260). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process: mitotic cell cycle G2/M transition DNA damage checkpoint; eggshell chorion gene amplification; positive regulation of NFAT protein import into nucleus. 12 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cullin homology; Cullin protein, neddylation domain; Cullin repeat-like-containing domain; Cullin, N-terminal; Cullin, conserved site; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624041_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Cul-4. Gene sequence location is 2R:3989765..3993819.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Ayyub, 2011, J. Genet. 90(2): 239--249 Sequence features BKN21967 HFA07243
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 44A4-44A4   Limits computationally determined from genome sequence between P{lacW}Vps28k16503 and P{EP}kermitEP493
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cul-4 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cul-4-RA FBtr0088821  NM_136508   3342   821 Cul-4-RB FBtr0301355  NM_001169613   3405   821
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cul-4-PA   FBpp0087897   94.4   821   8.98     NP_610352   AAF59135 Cul-4-PB   FBpp0290569   94.4   821   8.98     NP_001163084   ACZ94363
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cullin, N-terminal (IPR001373) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991) Cullin, conserved site (IPR016157) Cullin homology (IPR016158) Cullin repeat-like-containing domain (IPR016159) Cullin protein, neddylation domain (IPR019559)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263213   AA391292   AA439298   AA821182   AE013599 AAF59135   AE013599 ACZ94363   AI259462   AI546387   AQ073653   AW941400   AY051648 AAK93072   BF493678   BF503025   BF506450   BG637102   BG638762   BH615090   BI227940   BI230884   BI231139   BI633065   BI637473   BI637823   BT021374 AAX33522   BT050475   CO179122   CO263092   CO263206   CO263711   CO269205   CO269766   CO279154   CO282552   CO285928   CO285935   CO287760   CO288289   CO288711   CO290566   CO292779   CO300836   CO305881   CO308636   CO310015   CO310118   CO310689   CO313993   CO314005   CO318557   CO319184   CO319240   CO319593   CO324118   CO327548   CO327549   CO342331   EC058412   EC059257   EC061223   EC062757   EC064585   EC070742   EC079849   EC081593   EC081773   EC082098   EC082746   EC086618   EC089146   EC089956   EC196822   EC201426   EC202813   EC204538   EC207308   EC213388   EC218891   EC219577   EC220030   EC224812   EC227237   EC227429   EC230521   EC231514   EC232890   EC237302   EC237963   EC242037   EC244164   EC245442   EC246632   EC246637   EC254539   EC259183   EC260483   ES696061   EV599386   GH748257   GH748803   GH749775   GH751149   GH753667   GH755943   GH755969   GH756875   GH756985   GH759078   GH780173   GH780539   GH782317   GH786449   GH787927   GH789509   GH790303   GH794922   GH796310   GH798621   GH799100   GH799154   GH799599   GH799973   GH801146   GH801281   GH801671   GH801853   GH806440   GH808263   GH808656   GH810203   GH810383   GH810772   GH810853   GH811005   GH812165   GH815288   GH815807   GH818742   GH818985   GH819144   GH820161   GH820539   GH821060   GH825553   GH830694   GH831415   GH831743   GH834173   GH835102   GH836043   GH837100   GH837150   GH837632   GH841550   GH841969   GH844081   GH846681   GH849952   GH850125   GH859296   GH862590   GH863141   GH864719   GH864841   GH865564   GH870211   GH877207   GH877642   GH878598   GH878728   GH883322   GH883364   GH884384   GH885274   GH896300   GH896667   GH897248   GH898286   GH898295   GH903768   GH906032   GH911698   GH912582   GH912663   GH912781   GH913061   GH913644   GH915477   GH919112   GH924201   GH925812   GH927450   GH929280   GH929409   GH930048   GH930416   GH932917   GH934902   GH938538   GH938810
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q961E0 Q5BI50
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033260    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033260 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033260 expression level Developmental Stage   Expression Level embryo 00-02hr    2590 embryo 02-04hr    1820 embryo 04-06hr    2737 embryo 06-08hr    2521 embryo 08-10hr    2493 embryo 10-12hr    1992 embryo 12-14hr    1819 embryo 14-16hr    966 embryo 16-18hr    993 embryo 18-20hr    662 embryo 20-22hr    1021 embryo 22-24hr    1051 larva L1    1022 larva L2    1086 larva L3 12hr old    944 larva L3 puffstage 1-2    847 larva L3 puffstage 3-6    1157 larva L3 puffstage 7-9    1475 white prepupae new    1397 white prepupae 12hr    1362 white prepupae 24hr    1443 pupae 2d postWPP    1051 pupae 3d postWPP    751 pupae 4d postWPP    672 adult male 01day    802 adult male 05day    845 adult male 30day    700 adult female 01day    1015 adult female 05day    2071 adult female 30day    1981 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2590) embryo 02-04hr  (1820) embryo 04-06hr  (2737) embryo 06-08hr  (2521) embryo 08-10hr  (2493) embryo 10-12hr  (1992) embryo 12-14hr  (1819) embryo 14-16hr  (966) embryo 16-18hr  (993) embryo 18-20hr  (662) embryo 20-22hr  (1021) embryo 22-24hr  (1051) larva L1  (1022) larva L2  (1086) larva L3 12hr old  (944) larva L3 puffstage 1-2  (847) larva L3 puffstage 3-6  (1157) larva L3 puffstage 7-9  (1475) white prepupae new  (1397) white prepupae 12hr  (1362) white prepupae 24hr  (1443) pupae 2d postWPP  (1051) pupae 3d postWPP  (751) pupae 4d postWPP  (672) adult male 01day  (802) adult male 05day  (845) adult male 30day  (700) adult female 01day  (1015) adult female 05day  (2071) adult female 30day  (1981) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2590) embryo 02-04hr  (1820) embryo 04-06hr  (2737) embryo 06-08hr  (2521) embryo 08-10hr  (2493) embryo 10-12hr  (1992) embryo 12-14hr  (1819) embryo 14-16hr    966 embryo 16-18hr    993 embryo 18-20hr    662 embryo 20-22hr    1021 embryo 22-24hr    1051 larva L1    1022 larva L2    1086 larva L3 12hr old    944 larva L3 puffstage 1-2    847 larva L3 puffstage 3-6    1157 larva L3 puffstage 7-9  1475 white prepupae new    1397 white prepupae 12hr    1362 white prepupae 24hr  1443 pupae 2d postWPP    1051 pupae 3d postWPP    751 pupae 4d postWPP    672 adult male 01day    802 adult male 05day    845 adult male 30day    700 adult female 01day    1015 adult female 05day  (2071) adult female 30day  (1981) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2590 embryo 02-04hr    1820 embryo 04-06hr    2737 embryo 06-08hr    2521 embryo 08-10hr    2493 embryo 10-12hr    1992 embryo 12-14hr    1819 embryo 14-16hr    966 embryo 16-18hr    993 embryo 18-20hr    662 embryo 20-22hr    1021 embryo 22-24hr    1051 larva L1    1022 larva L2    1086 larva L3 12hr old    944 larva L3 puffstage 1-2    847 larva L3 puffstage 3-6    1157 larva L3 puffstage 7-9    1475 white prepupae new    1397 white prepupae 12hr    1362 white prepupae 24hr    1443 pupae 2d postWPP    1051 pupae 3d postWPP    751 pupae 4d postWPP    672 adult male 01day    802 adult male 05day    845 adult male 30day    700 adult female 01day    1015 adult female 05day    2071 adult female 30day    1981 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2590 embryo 02-04hr    1820 embryo 04-06hr    2737 embryo 06-08hr    2521 embryo 08-10hr    2493 embryo 10-12hr    1992 embryo 12-14hr    1819 embryo 14-16hr    966 embryo 16-18hr    993 embryo 18-20hr    662 embryo 20-22hr    1021 embryo 22-24hr    1051 larva L1    1022 larva L2    1086 larva L3 12hr old    944 larva L3 puffstage 1-2    847 larva L3 puffstage 3-6    1157 larva L3 puffstage 7-9    1475 white prepupae new    1397 white prepupae 12hr    1362 white prepupae 24hr    1443 pupae 2d postWPP    1051 pupae 3d postWPP    751 pupae 4d postWPP    672 adult male 01day    802 adult male 05day    845 adult male 30day    700 adult female 01day    1015 adult female 05day    2071 adult female 30day    1981 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033260 expression level Developmental Stage   Expression Level embryo 00-02hr    2590 embryo 02-04hr    1820 embryo 04-06hr    2737 embryo 06-08hr    2521 embryo 08-10hr    2493 embryo 10-12hr    1992 embryo 12-14hr    1819 embryo 14-16hr    966 embryo 16-18hr    993 embryo 18-20hr    662 embryo 20-22hr    1021 embryo 22-24hr    1051 larva L1    1022 larva L2    1086 larva L3 12hr old    944 larva L3 puffstage 1-2    847 larva L3 puffstage 3-6    1157 larva L3 puffstage 7-9    1475 white prepupae new    1397 white prepupae 12hr    1362 white prepupae 24hr    1443 pupae 2d postWPP    1051 pupae 3d postWPP    751 pupae 4d postWPP    672 adult male 01day    802 adult male 05day    845 adult male 30day    700 adult female 01day    1015 adult female 05day    2071 adult female 30day    1981 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2590) embryo 02-04hr  (1820) embryo 04-06hr  (2737) embryo 06-08hr  (2521) embryo 08-10hr  (2493) embryo 10-12hr  (1992) embryo 12-14hr  (1819) embryo 14-16hr  (966) embryo 16-18hr  (993) embryo 18-20hr  (662) embryo 20-22hr  (1021) embryo 22-24hr  (1051) larva L1  (1022) larva L2  (1086) larva L3 12hr old  (944) larva L3 puffstage 1-2  (847) larva L3 puffstage 3-6  (1157) larva L3 puffstage 7-9  (1475) white prepupae new  (1397) white prepupae 12hr  (1362) white prepupae 24hr  (1443) pupae 2d postWPP  (1051) pupae 3d postWPP  (751) pupae 4d postWPP  (672) adult male 01day  (802) adult male 05day  (845) adult male 30day  (700) adult female 01day  (1015) adult female 05day  (2071) adult female 30day  (1981) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2590) embryo 02-04hr  1820 embryo 04-06hr  (2737) embryo 06-08hr  (2521) embryo 08-10hr  (2493) embryo 10-12hr  1992 embryo 12-14hr  1819 embryo 14-16hr    966 embryo 16-18hr    993 embryo 18-20hr    662 embryo 20-22hr    1021 embryo 22-24hr    1051 larva L1    1022 larva L2    1086 larva L3 12hr old    944 larva L3 puffstage 1-2    847 larva L3 puffstage 3-6    1157 larva L3 puffstage 7-9  1475 white prepupae new    1397 white prepupae 12hr    1362 white prepupae 24hr  1443 pupae 2d postWPP    1051 pupae 3d postWPP    751 pupae 4d postWPP    672 adult male 01day    802 adult male 05day    845 adult male 30day    700 adult female 01day    1015 adult female 05day  2071 adult female 30day  1981 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2590 embryo 02-04hr    1820 embryo 04-06hr    2737 embryo 06-08hr    2521 embryo 08-10hr    2493 embryo 10-12hr    1992 embryo 12-14hr    1819 embryo 14-16hr    966 embryo 16-18hr    993 embryo 18-20hr    662 embryo 20-22hr    1021 embryo 22-24hr    1051 larva L1    1022 larva L2    1086 larva L3 12hr old    944 larva L3 puffstage 1-2    847 larva L3 puffstage 3-6    1157 larva L3 puffstage 7-9    1475 white prepupae new    1397 white prepupae 12hr    1362 white prepupae 24hr    1443 pupae 2d postWPP    1051 pupae 3d postWPP    751 pupae 4d postWPP    672 adult male 01day    802 adult male 05day    845 adult male 30day    700 adult female 01day    1015 adult female 05day    2071 adult female 30day    1981 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2590 embryo 02-04hr    1820 embryo 04-06hr    2737 embryo 06-08hr    2521 embryo 08-10hr    2493 embryo 10-12hr    1992 embryo 12-14hr    1819 embryo 14-16hr    966 embryo 16-18hr    993 embryo 18-20hr    662 embryo 20-22hr    1021 embryo 22-24hr    1051 larva L1    1022 larva L2    1086 larva L3 12hr old    944 larva L3 puffstage 1-2    847 larva L3 puffstage 3-6    1157 larva L3 puffstage 7-9    1475 white prepupae new    1397 white prepupae 12hr    1362 white prepupae 24hr    1443 pupae 2d postWPP    1051 pupae 3d postWPP    751 pupae 4d postWPP    672 adult male 01day    802 adult male 05day    845 adult male 30day    700 adult female 01day    1015 adult female 05day    2071 adult female 30day    1981 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033260    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033260 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033260 expression level Tissue   Expression Level Larval Central Nervous System    408.525 Larval Midgut    197.9 Larval Hindgut    209.5 Larval Malpighian Tubules    196 Larval Fat Body    146.3 Larval Salivary Gland    312.5 Larval Trachea    328.1 Larval Carcass    251.525 Adult Head    135.3 Adult Eye    180.55 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    203.1 Adult Crop    203.9 Adult Midgut    148.5 Adult Hindgut    161 Adult Malpighian Tubules    239.7 Adult Fat Body    268.1 Adult Salivary Gland    189.6 Adult Heart    220.3 Adult VirginFemale Spermatheca    257.9 Adult InseminatedFemale Spermatheca    303.3 Adult Ovary    368.1 Adult Testis    69.7 Adult Male Accessory Gland    193.4 Adult Carcass    260.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    408.525 Larval Midgut    197.9 Larval Hindgut    209.5 Larval Malpighian Tubules    196 Larval Fat Body    146.3 Larval Salivary Gland    312.5 Larval Trachea    328.1 Larval Carcass    251.525 Adult Head    135.3 Adult Eye    180.55 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    203.1 Adult Crop    203.9 Adult Midgut    148.5 Adult Hindgut    161 Adult Malpighian Tubules    239.7 Adult Fat Body    268.1 Adult Salivary Gland    189.6 Adult Heart    220.3 Adult VirginFemale Spermatheca    257.9 Adult InseminatedFemale Spermatheca    303.3 Adult Ovary    368.1 Adult Testis    69.7 Adult Male Accessory Gland    193.4 Adult Carcass    260.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    408.525 Larval Midgut    197.9 Larval Hindgut    209.5 Larval Malpighian Tubules    196 Larval Fat Body    146.3 Larval Salivary Gland    312.5 Larval Trachea    328.1 Larval Carcass    251.525 Adult Head    135.3 Adult Eye    180.55 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    203.1 Adult Crop    203.9 Adult Midgut    148.5 Adult Hindgut    161 Adult Malpighian Tubules    239.7 Adult Fat Body    268.1 Adult Salivary Gland    189.6 Adult Heart    220.3 Adult VirginFemale Spermatheca    257.9 Adult InseminatedFemale Spermatheca    303.3 Adult Ovary    368.1 Adult Testis    69.7 Adult Male Accessory Gland    193.4 Adult Carcass    260.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    408.525 Larval Midgut    197.9 Larval Hindgut    209.5 Larval Malpighian Tubules    196 Larval Fat Body    146.3 Larval Salivary Gland    312.5 Larval Trachea    328.1 Larval Carcass    251.525 Adult Head    135.3 Adult Eye    180.55 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    203.1 Adult Crop    203.9 Adult Midgut    148.5 Adult Hindgut    161 Adult Malpighian Tubules    239.7 Adult Fat Body    268.1 Adult Salivary Gland    189.6 Adult Heart    220.3 Adult VirginFemale Spermatheca    257.9 Adult InseminatedFemale Spermatheca    303.3 Adult Ovary    368.1 Adult Testis    69.7 Adult Male Accessory Gland    193.4 Adult Carcass    260.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033260 expression level Tissue   Expression Level Larval Central Nervous System    408.525 Larval Midgut    197.9 Larval Hindgut    209.5 Larval Malpighian Tubules    196 Larval Fat Body    146.3 Larval Salivary Gland    312.5 Larval Trachea    328.1 Larval Carcass    251.525 Adult Head    135.3 Adult Eye    180.55 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    203.1 Adult Crop    203.9 Adult Midgut    148.5 Adult Hindgut    161 Adult Malpighian Tubules    239.7 Adult Fat Body    268.1 Adult Salivary Gland    189.6 Adult Heart    220.3 Adult VirginFemale Spermatheca    257.9 Adult InseminatedFemale Spermatheca    303.3 Adult Ovary    368.1 Adult Testis    69.7 Adult Male Accessory Gland    193.4 Adult Carcass    260.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    408.525 Larval Midgut    197.9 Larval Hindgut    209.5 Larval Malpighian Tubules    196 Larval Fat Body    146.3 Larval Salivary Gland    312.5 Larval Trachea    328.1 Larval Carcass    251.525 Adult Head    135.3 Adult Eye    180.55 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    203.1 Adult Crop    203.9 Adult Midgut    148.5 Adult Hindgut    161 Adult Malpighian Tubules    239.7 Adult Fat Body    268.1 Adult Salivary Gland    189.6 Adult Heart    220.3 Adult VirginFemale Spermatheca    257.9 Adult InseminatedFemale Spermatheca    303.3 Adult Ovary    368.1 Adult Testis    69.7 Adult Male Accessory Gland    193.4 Adult Carcass    260.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    408.525 Larval Midgut    197.9 Larval Hindgut    209.5 Larval Malpighian Tubules    196 Larval Fat Body    146.3 Larval Salivary Gland    312.5 Larval Trachea    328.1 Larval Carcass    251.525 Adult Head    135.3 Adult Eye    180.55 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    203.1 Adult Crop    203.9 Adult Midgut    148.5 Adult Hindgut    161 Adult Malpighian Tubules    239.7 Adult Fat Body    268.1 Adult Salivary Gland    189.6 Adult Heart    220.3 Adult VirginFemale Spermatheca    257.9 Adult InseminatedFemale Spermatheca    303.3 Adult Ovary    368.1 Adult Testis    69.7 Adult Male Accessory Gland    193.4 Adult Carcass    260.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    408.525 Larval Midgut    197.9 Larval Hindgut    209.5 Larval Malpighian Tubules    196 Larval Fat Body    146.3 Larval Salivary Gland    312.5 Larval Trachea    328.1 Larval Carcass    251.525 Adult Head    135.3 Adult Eye    180.55 Adult Brain    153.2 Adult Thoracic-Abdominal Ganglion    203.1 Adult Crop    203.9 Adult Midgut    148.5 Adult Hindgut    161 Adult Malpighian Tubules    239.7 Adult Fat Body    268.1 Adult Salivary Gland    189.6 Adult Heart    220.3 Adult VirginFemale Spermatheca    257.9 Adult InseminatedFemale Spermatheca    303.3 Adult Ovary    368.1 Adult Testis    69.7 Adult Male Accessory Gland    193.4 Adult Carcass    260.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    135.3   NA  Eye    180.55   NA  Brain    153.2   408.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    203.1   NA  Crop    203.9   197.9  Midgut    148.5   209.5  Hindgut    161   196  Malpighian Tubules    239.7   146.3  Fat Body    268.1   312.5  Salivary Gland    189.6   NA  Heart    220.3   328.1  Trachea    NA   NA  VirginFemale Spermatheca    257.9   NA  InseminatedFemale Spermatheca    303.3   NA  Ovary    368.1   NA  Testis    69.7   NA  Male Accessory Gland    193.4   251.525  Carcass    260.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033260 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8711-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone Cul-4unspecified lethal | second instar larval stage Cul-4G1-3 Cul-4G3-5 Cul-4JJ11 Cul-4L2-1 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Cul-4GD14006 Other Phenotypes Allele cell shape defective | somatic clone Cul-4L2-1 decreased cell death | somatic clone Cul-4KG02900 decreased cell number | somatic clone Cul-4G1-3 visible, with Scer\GAL4pnr-MD237 Cul-4GD14006 Phenotype manifest in Allele eye | somatic clone Cul-4unspecified follicle cell | second instar larval stage Cul-4G1-3 mesothoracic tergum, with Scer\GAL4pnr-MD237 Cul-4GD14006
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Cul-4 Class Mutagen Stocks Known lesion Cul-4KG02900 P-element activity 2 -- Cul-411L P-element activity 1 Yes Cul-46AP P-element activity 1 Yes Cul-4EP2518 P-element activity 1 -- Cul-4G1-3 P-element activity 0 Yes Cul-4G3-5 P-element activity 0 Yes Cul-4JJ11 ethyl methanesulfonate 0 Yes Cul-4L2-1 P-element activity 0 Yes Cul-4unspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cul-4 Class Mutagen Stocks Known lesion Cul-4GD14006 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cul-4KK101901 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cul-4G2935 0 --
Aneuploid Aberrations
Disrupted in	Df(2R)BSC266 (Christensen et al., 2008.12.28) Df(2R)BSC267 (Christensen et al., 2007.10.29) Df(2R)Exel6056 (Ryder, 2004.4.26) Df(2R)Exel7094 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data characterization construct P{UAS-Cul-4.Exel} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Cul-4EP2518 NA miscellaneous insertions P{SUPor-P}Cul-4KG02900 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
eggshell chorion gene amplification inferred from direct assay (Lin et al., 2009) mitotic cell cycle G2/M transition DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) positive regulation of NFAT protein import into nucleus inferred from mutant phenotype (Gwack et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ubiquitin-protein ligase activity inferred from sequence or structural similarity with Saccharomyces CDC53 (FlyBase, 1992-) ubiquitin protein ligase binding inferred from electronic annotation with InterPro:IPR001373, InterPro:IPR016157, InterPro:IPR016158, InterPro:IPR019559 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein ubiquitination involved in ubiquitin-dependent protein catabolic process inferred from sequence or structural similarity with UniProtKB:Q1361 (Hu et al., 2008)
Cellular Component
CV term Evidence References
cullin-RING ubiquitin ligase complex inferred from electronic annotation with InterPro:IPR001373, InterPro:IPR016157, InterPro:IPR016158, InterPro:IPR019559 (FlyBase Curators et al., 2004-) nuclear ubiquitin ligase complex inferred from sequence or structural similarity with Saccharomyces CDC53 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cul-4 allele Gene References unspecified H (Mueller et al., 2005) L (Singh et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61637 DroID - A comprehensive database of gene and protein interactions. • FBgn0033260 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35780
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11213 Dere\GG10678 Dgri\GH19988 Dmoj\GI20275 Dper\GL17383 Dpse\GA21273 Dsec\GM20725 Dvir\GJ20228 Dwil\GK23161 Dyak\GE23323
Curated drosophilid orthologs	Dpse\GA21273
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003466-PA Aedes aegypti (mosquito) AGAP007727-PA Anopheles gambiae (mosquito) XP_392800.3 Apis mellifera (honey bee) XP_001950946.1 Acyrthosiphon pisum (pea aphid) At5g46210.1 Arabidopsis thaliana (wall cress) 19177 Batrachochytrium dendrobatidis (chytrid fungus) 277112 Branchiostoma floridae (lancelet) XP_001896506.1 Brugia malayi (roundworm nematode) BGIBMGA005758-PA Bombyx mori (silk worm) ENSBTAP00000024713 Bos taurus (bovine) ENSCAFP00000027368 Canis familiaris (dog) ENSCINP00000002432 Ciona intestinalis (sea squirt) CMN113C Cyanidioschyzon merolae (red alga) CPIJ010574 Culex pipens (mosquito) ENSCPOP00000003183 Cavia porcellus (guinea pig) 133199 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000016385 Ciona savignyi (sedentary tunicate) 227595 Capitella spl (polychaete worm) DDB0266743 Dictyostelium discoideum (amoeba) 302594 Daphnia pulex (daphnia) ENSDARP00000079730 Danio rerio (zebra fish) ENSECAP00000021423 Equus caballus (horse) XP_657526 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000023009 Gymnopilus aculeatus (mushroom) ENSGALP00000013926 Gallus gallus (chicken) 185316 Hypsipyla robusta (cedar shoot borer) ENSP00000360373 Homo sapiens (human) ISCW006143-PA Ixodes scapularis (deer tick) 187016 Lottia gigantea (owl limpet) 15020 Monocosta brevicollis (choanoflagellate) ENSMODP00000037084 Monodelphis domestica (gray opossum) ENSMMUP00000025356 Macaca mulatta (rhesus monkey) ENSMUSP00000110771 Mus musculus (house mouse) 171734 Nematostella vectensis (starlet anemone) XP_001603521.1 Nasonia vitripennis (wasp) ENSOANP00000004087 Ornithorynchus anatinus (platypus) ENSORLP00000001369 Oryzias latipes (japanese killifish) LOC_Os03g57290.1 Oryza sativa (asian rice) 32109 Ostreococcus tauri (green alga) PFF1445c Plasmodium falciparum (protozoal parasite) PHUM002373-PA Pediculus humanus (human body louse) PP11431 Pristionchus pacificus (nematode) 193769 Physcomitrella patens (moss) ENSPPYP00000006296 Pongo pygmaeus (orangutan) 71522 Phytophthora ramorum (sudden oak death pathogen) 109251 Phytophthora sojae (root rot pathogen) 828634 Populus trichocarpa (black cottonwood) ENSPTRP00000038287 Pan troglodytes (chimpanzee) ENSRNOP00000058321 Rattus norvegicus (norway rat) 5048004 Sorghum bicolor (sorghum) Smp_082850.2 Schistosoma mansoni (trematode parasite) SPAC3A11.08 Schizosaccharomyces pombe (fission yeast) 24582 Trichoplax adhaerens (metazoa) TA17625 Theileria annulata (apicomplexan parasite) XP_001814199.1 Tribolium castaneum (red flour beetle) Tc00.1047053511075.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000003215 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024586 Takifugu rubripes (pufferfish Takifugu) 133.m00069 Tetrahymena thermophila (ciliate protozoa) 80222.m00144 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000009705 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16784 NV17699 LH11887 ISCW006143 FBgn0240518 FBgn0225123 FBgn0207368 FBgn0175606 JGI_V11_302594 FBgn0081261 FBgn0154986 FBgn0143011 FBgn0127452 FBgn0102984 FBgn0088253 CPIJ010574 BGIBMGA005758 ACYPI004467 GB11554 AGAP007727 AAEL003466 PHUM613890
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	17253 w1118; P{EP}Cul-4EP2518 13335 y1; P{SUPor-P}Cul-4KG02900/CyO; ry506 34053 y1 w*; P{FRT(whs)}G13 Cul-411L/CyO 34052 w*; Cul-46AP/CyO, P{GAL4-twi.G}2.2, P{UAS-2xEGFP}AH2.2
Kyoto	111538 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{SUPor-P}Cul-4KG02900 /CyO y+
VDRC	v105668 P{KK101901}VIE-260B v44829 w1118; P{GD14006}v44829
Genomic Clones ( 2 )
	BACR09N11 BACR38O04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 189 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM14815 LP02965
Other clones	FI05474
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02007 AT08920 AT18919 LD06302 LD10202 LD13828 LD35425 LD47949 LP02880 RE16144 RE19338 RE25332 SD14962 SD19510 SD19919 SD27036
Other clones	19054 28467 29628 44863 58303 64672 64720 72462 76130 81556 97429 98092 108363 108404 147099 156098 173005 175360 176150 214277.43 214443.37 214507.38 CK01.17A.D12 CK01.74C.G5 CK01.78D.F1 CK01.82B.H7 CK01.83D.E5 CK01.86B.F4 CK01.87D.C9 CK01.95C.A2 CK01.104B.H5 CK01.104D.F6 CK01.104D.G6 CK01.107A.F4 CK01.123B.H2 CK01.129B.C12 Dmel_neb_013760_0861_3211 EK058527 EK061206 EK061216 EK066707 EK068154 EK069211 EK074333 EK087431 EK087755 EK089354 EK093861 EK095842 EK133645 EK160713 EK179512 EK192639 EK200938 EK220246 EK220535 EK222306 EK234622 EK234655 EK249621 EK258951 EK272757 EK276518 EK277404 EK279255 EP07454 EP07455 EP14523 RP003012472 RP003033126 RP003041262 RP003071438 RP003073772 RP003077158 RP003087742 RP003093953 RP003095004 RP003096632 RP003102478 RP003110792 RP003110872 RP003111959 RP003112039 RP003118265 RP003127314 RP003127857 RP003156593 RP003167072 RP003167528 RP003174761 RP003174848 RP003181885 RP003189958 RP003192192 RP003195567 RP003197235 RP003199130 RP003200360 RP003200696 RP003203394 RP003209676 RP003212063 RP003214486 RP003230262 RP003230716 RP003234271 RP003234502 RP003236531 RP003238092 RP003254720 RP003258739 RP003267772 RP003270203 RP003280171 RP003302228 RP003308620 RP003323236 RP003328464 RP003347991 RP003359987 RP003368319 RP003371009 RP003377218 RP003377503 RP003381660 RP003387572 RP003390921 RP003411029 RP003420636 RP003429999 RP003438180 RP003440963 RP003444095 RP003451547 RP003453153 RP003453750 RP003458011 RP003463550 RP003466704 RP003474416 RP003477713 RP003478820 RP003485087 RP003489792 RP003491663 RP003492063 RP003493595 RP003522288 RP003545142 RP003547711 RP003548706 RP003580087 RP003580857 RP003581664 RP003587650 RP003602755 RP003614020 RP003617803 RP003624190 RP003627487 RP003635674 RP003644039 RP003644307 RP003651193 RP003654413 RP003654633 RP003669419 RP003670177 RP003671862 RP003682278
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033260 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35780
Antibody Information
	polyclonal (Lin et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Cul-4 cul-4 (FlyBase, 2009-)
Source for database merge of
Additional comments	Renamed to be consistent with FlyBase nomenclature rules. (FlyBase, 2009-)
Other Comments
	Cul-4 is involved in the gene amplification process in follicle cells. (Lin et al., 2009) Cul-4 is required for normal Orc2 localization at gene amplification foci of follicle cells. (Lin et al., 2009) cul-4 blocks degradation of dup protein after γ-irradiation. (Higa et al., 2003) S2 cells are treated with dsRNA made from templates generated with primers directed against this gene to assess effect on degradation of dup and geminin genes. (Higa et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136508 NM_001169613 RefSeq (Proteins) • NP_610352 NP_001163084 DDBJ / EMBL / GenBank • AA821182 AAF59135 AAK93072 AAX33522 ACZ94363 AQ073653 AW941400 AY051648 BH615090 BT021374 Entrez Gene - A searchable database of RefSeq genes. • 35780 UniProtKB/TrEMBL • Q5BI50 Q961E0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cullin, N-terminal (IPR001373) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991) Cullin, conserved site (IPR016157) Cullin homology (IPR016158) Cullin repeat-like-containing domain (IPR016159) Cullin protein, neddylation domain (IPR019559)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61637 DroID - A comprehensive database of gene and protein interactions. • FBgn0033260 DRSC - Results from RNAi screens. • FBgn0033260 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033260 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8711-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033260 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35780 InParanoid A subset of ortholog calls from InParanoid. • AAEL003466-PA Aedes aegypti (mosquito) AGAP007727-PA Anopheles gambiae (mosquito) XP_392800.3 Apis mellifera (honey bee) XP_001950946.1 Acyrthosiphon pisum (pea aphid) At5g46210.1 Arabidopsis thaliana (wall cress) 19177 Batrachochytrium dendrobatidis (chytrid fungus) 277112 Branchiostoma floridae (lancelet) XP_001896506.1 Brugia malayi (roundworm nematode) BGIBMGA005758-PA Bombyx mori (silk worm) ENSBTAP00000024713 Bos taurus (bovine) ENSCAFP00000027368 Canis familiaris (dog) ENSCINP00000002432 Ciona intestinalis (sea squirt) CMN113C Cyanidioschyzon merolae (red alga) CPIJ010574 Culex pipens (mosquito) ENSCPOP00000003183 Cavia porcellus (guinea pig) 133199 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000016385 Ciona savignyi (sedentary tunicate) 227595 Capitella spl (polychaete worm) DDB0266743 Dictyostelium discoideum (amoeba) 302594 Daphnia pulex (daphnia) ENSDARP00000079730 Danio rerio (zebra fish) ENSECAP00000021423 Equus caballus (horse) XP_657526 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000023009 Gymnopilus aculeatus (mushroom) ENSGALP00000013926 Gallus gallus (chicken) 185316 Hypsipyla robusta (cedar shoot borer) ENSP00000360373 Homo sapiens (human) ISCW006143-PA Ixodes scapularis (deer tick) 187016 Lottia gigantea (owl limpet) 15020 Monocosta brevicollis (choanoflagellate) ENSMODP00000037084 Monodelphis domestica (gray opossum) ENSMMUP00000025356 Macaca mulatta (rhesus monkey) ENSMUSP00000110771 Mus musculus (house mouse) 171734 Nematostella vectensis (starlet anemone) XP_001603521.1 Nasonia vitripennis (wasp) ENSOANP00000004087 Ornithorynchus anatinus (platypus) ENSORLP00000001369 Oryzias latipes (japanese killifish) LOC_Os03g57290.1 Oryza sativa (asian rice) 32109 Ostreococcus tauri (green alga) PFF1445c Plasmodium falciparum (protozoal parasite) PHUM002373-PA Pediculus humanus (human body louse) PP11431 Pristionchus pacificus (nematode) 193769 Physcomitrella patens (moss) ENSPPYP00000006296 Pongo pygmaeus (orangutan) 71522 Phytophthora ramorum (sudden oak death pathogen) 109251 Phytophthora sojae (root rot pathogen) 828634 Populus trichocarpa (black cottonwood) ENSPTRP00000038287 Pan troglodytes (chimpanzee) ENSRNOP00000058321 Rattus norvegicus (norway rat) 5048004 Sorghum bicolor (sorghum) Smp_082850.2 Schistosoma mansoni (trematode parasite) SPAC3A11.08 Schizosaccharomyces pombe (fission yeast) 24582 Trichoplax adhaerens (metazoa) TA17625 Theileria annulata (apicomplexan parasite) XP_001814199.1 Tribolium castaneum (red flour beetle) Tc00.1047053511075.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000003215 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024586 Takifugu rubripes (pufferfish Takifugu) 133.m00069 Tetrahymena thermophila (ciliate protozoa) 80222.m00144 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000009705 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/cul4.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35780 modMine - Data generated by the modENCODE project. • FBgn0033260 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16784 NV17699 LH11887 ISCW006143 FBgn0240518 FBgn0225123 FBgn0207368 FBgn0175606 JGI_V11_302594 FBgn0081261 FBgn0154986 FBgn0143011 FBgn0127452 FBgn0102984 FBgn0088253 CPIJ010574 BGIBMGA005758 ACYPI004467 GB11554 AGAP007727 AAEL003466 PHUM613890
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG8711 (Ou et al., 2002, Keleman et al., 2009.8.5, Lin et al., 2009) Cul-4 (Bjorklund et al., 2006, Gwack et al., 2007, Martin et al., 2007, ) CUL4 (Higa et al., 2003, Higa et al., 2006, Kondo and Perrimon, 2011) Cul4 (Ou et al., 2003, Lee and Zacharek, 2007, Zaratiegui, 2007, Zhu et al., 2005, Wu et al., 2005, Reynolds et al., 2008, Shibutani et al., 2008, Hu et al., 2008, Hall et al., 2008, Lin et al., 2009, Avet-Rochex et al., 2010) cul-4 (Christensen et al., 2007.10.29, Geng and MacDonald, 2007, Somma et al., 2008, Christensen et al., 2008.12.28) cul4 (Ayyub, 2011) dCul4 (Hu et al., 2008) DMcul-4 (Filippov et al., 2000)
Name Synonym	cul-4   cullin-4   Cullin-4
Secondary FlyBase IDs
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 3 ) Review  ( 2 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Computer file  ( 2 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Ayyub, 2011, J. Genet. 90(2): 239--249 Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila. [FBrf0214802] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Avet-Rochex et al., 2010, BMC Dev. Biol. 10: 65 An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. [FBrf0211137] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...