FlyBase Gene Report: Dmel\Cirl

General Information

Symbol

Dmel\Cirl

Species

D. melanogaster

Name

Calcium-independent receptor for α-latrotoxin

Annotation Symbol

CG8639

Feature Type

protein_coding_gene

FlyBase ID

FBgn0033313

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

G-protein coupled receptor - involved in the perception of tactile, proprioceptive, and auditory stimuli through chordotonal neurons of the PNS - sensitizes these neurons for the detection of mechanical stimulation by amplifying their input-output function (Interactive Fly, Cirl )

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

dCirl, latrophilin

Key Links

Genomic Location

Cytogenetic map

44D4-44D5

Sequence location

2R:8,614,722..8,625,203 [+]

Recombination map

2-59

RefSeq locus

NT_033778 REGION:8614722..8625203

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables carbohydrate binding

inferred from electronic annotation with InterPro:IPR000922

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables G protein-coupled receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000244280

(assigned by GO_Central )

(Gaudet et al., 2011)

enables latrotoxin receptor activity

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

Biological Process (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in adult locomotory behavior

inferred from mutant phenotype

(van der Voet et al., 2016)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000244280

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in cell surface receptor signaling pathway

inferred from electronic annotation with InterPro:IPR017981

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in G protein-coupled receptor signaling pathway

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

is_active_in integral component of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000244280

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

CLASS B GPCRs, SUBFAMILY B2

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. (A1Z7G7)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CLASS B GPCRs, SUBFAMILY B2 -: The B2 subfamily of Class B GPCRs are characterized by a long extracellular N-terminal domain and a GPCR proteolytic site (GPS), which is located within a conserved sixty residue domain N-terminally to the first transmembrane domain. (Adapted from FBrf0147071 and FBrf0221117).

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cirl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A1Z7G7)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.49

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cirl-RB

FBtr0290112

NM_001144148

6940

1643

Cirl-RE

FBtr0301363

NM_001169619

5860

1639

Cirl-RF

FBtr0305080

NM_001259275

3610

932

Cirl-RG

FBtr0305081

NM_136553

7571

1695

Cirl-RH

FBtr0305082

NM_001259276

7805

1643

Cirl-RI

FBtr0310448

NM_001273878

7631

1711

Cirl-RJ

FBtr0310449

NM_001273879

4305

1000

Cirl-RK

FBtr0310450

NM_001273880

4166

932

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Cirl-PB

FBpp0288551

180.0

1643

7.09

NP_001137620

ACL83074

Cirl-PE

FBpp0290577

179.5

1639

7.05

NP_001163090

ACZ94369

Cirl-PF

FBpp0293617

101.6

932

8.20

NP_001246204

AFH07959

Cirl-PG

FBpp0293618

185.8

1695

7.06

NP_610397

AAF59067

Cirl-PH

FBpp0293619

180.0

1643

7.09

NP_001246205

AFH07960

Cirl-PI

FBpp0302596

187.6

1711

7.00

NP_001260807

AGB93340

Cirl-PJ

FBpp0302597

109.2

1000

7.85

NP_001260808

AGB93341

Cirl-PK

FBpp0302598

101.6

932

8.20

NP_001260809

AGB93342

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1643 aa isoforms: Cirl-PB, Cirl-PH

932 aa isoforms: Cirl-PF, Cirl-PK

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.

(UniProt, A1Z7G7)

Post Translational Modification

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.

(UniProt, A1Z7G7)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cirl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

larva

(Scholz et al., 2015)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: TI{GAL4::p65}Cirl^GAL4-p65

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval abdominal lch5 neuron

(Scholz et al., 2017)

wandering third instar larval stage

larval abdominal lch5 neuron

(Scholz et al., 2015)

eo neuron of campaniform sensillum

(Scholz et al., 2015)

larval abdominal multidendritic neuron

(Scholz et al., 2015)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cirl in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cirl

View exonic expression by tissue for Dmel\Cirl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35846/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033313

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033313

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033313

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8639

Flygut - An atlas of the Drosophila adult midgut

FBgn0033313

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 13 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cirl

Transgenic constructs containing regulatory region of Cirl

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel8047

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

Cirl^GD14785

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

Cirl^GD14785

viable

Cirl^EY12930

Sterility

Allele

fertile

Cirl^EY12930

Other Phenotypes

Allele

abnormal developmental rate | embryonic stage

Cirl^KO.attP.w-

abnormal neurophysiology | larval stage

abnormal sensory perception | larval stage

abnormal sleep, with Scer\GAL4^elav.PU

hyperactive, with Scer\GAL4^elav.PU

hyperactive, with Scer\GAL4^nSyb.PU

Cirl^KK108383

Phenotype manifest in

Allele

embryonic epidermis

Cirl^KO.attP.w-

epithelial cell of wing disc | somatic clone

Cirl^KO.attP.w-

germ band

Cirl^KO.attP.w-

larval abdominal lch5 neuron

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (27)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ADGRL1

10 of 15

Yes

Hsap\ADGRL3

10 of 15

Yes

Hsap\ADGRL2

9 of 15

Yes

Hsap\ADGRL4

4 of 15

Yes

Hsap\ADGRE2

3 of 15

Yes

Hsap\ADGRE5

3 of 15

Yes

Hsap\ADGRE1

2 of 15

Yes

Hsap\ADGRE3

2 of 15

Yes

Hsap\ADGRG1

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Hsap\ADGRG6

2 of 15

Hsap\ADGRG7

2 of 15

Hsap\ADGRB1

1 of 15

Yes

Hsap\ADGRB2

1 of 15

Yes

Hsap\ADGRB3

1 of 15

Yes

Hsap\ADGRD1

1 of 15

Yes

Hsap\ADGRD2

1 of 15

Yes

Hsap\ADGRE4P

1 of 15

Yes

Hsap\ADGRF1

1 of 15

Hsap\ADGRF2

1 of 15

Yes

Hsap\ADGRF3

1 of 15

Yes

Hsap\ADGRF4

1 of 15

Yes

Hsap\ADGRF5

1 of 15

Hsap\EVA1C

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (24)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Adgrl1

11 of 15

Yes

Mmus\Adgrl2

9 of 15

Yes

Mmus\Adgrl3

9 of 15

Yes

Mmus\Adgrl4

4 of 15

Yes

Mmus\Adgre1

3 of 15

Yes

Mmus\Adgre4

2 of 15

Yes

Mmus\Adgre5

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

Mmus\Adgrb2

1 of 15

Yes

Mmus\Adgrb3

1 of 15

Yes

Mmus\Adgrd1

1 of 15

Yes

Mmus\Adgrf1

1 of 15

Mmus\Adgrf2

1 of 15

Yes

Mmus\Adgrf3

1 of 15

Yes

Mmus\Adgrf4

1 of 15

Yes

Mmus\Adgrf5

1 of 15

Mmus\Adgrg4

1 of 15

Mmus\Eva1c

1 of 15

Rattus norvegicus (Norway rat) (21)

Rnor\Adgrl2

9 of 13

Yes

Rnor\Adgrl1

6 of 13

Yes

Rnor\Adgrl3

6 of 13

Yes

Rnor\Adgre1

3 of 13

Yes

Rnor\Adgre5

3 of 13

Yes

Rnor\Adgrl4

3 of 13

Yes

Rnor\Adgrg2

2 of 13

Rnor\Adgrg3

2 of 13

Yes

Rnor\Adgrg5

2 of 13

Yes

Rnor\Adgrg6

2 of 13

Rnor\Adgrg7

2 of 13

Rnor\Adgrb2

1 of 13

Yes

Rnor\Adgrb3

1 of 13

Yes

Rnor\Adgrd1

1 of 13

Yes

Rnor\Adgre4

1 of 13

Yes

Rnor\Adgrf2

1 of 13

Yes

Rnor\Adgrf3

1 of 13

Yes

Rnor\Adgrf4

1 of 13

Yes

Rnor\Adgrf5

1 of 13

Yes

Rnor\Adgrg1

1 of 13

Yes

Rnor\Eva1c

1 of 13

Xenopus tropicalis (Western clawed frog) (12)

Xtro\adgrl1

3 of 12

Yes

Xtro\adgrg1

2 of 12

Yes

Xtro\adgrd1

1 of 12

Yes

Xtro\adgre1

1 of 12

Yes

Xtro\adgre5

1 of 12

Yes

Xtro\adgrf1

1 of 12

Yes

Xtro\adgrf3

1 of 12

Yes

Xtro\adgrl2

1 of 12

Yes

Xtro\adgrl3

1 of 12

Yes

Xtro\adgrv1

1 of 12

Yes

Xtro\eva1c

1 of 12

Xtro\LOC100498069

1 of 12

Yes

Danio rerio (Zebrafish) (65)

Drer\adgrl2a

9 of 15

Yes

Drer\adgrl3.1

6 of 15

Yes

Drer\LOC100535070

5 of 15

Yes

Drer\adgre5b.2

4 of 15

Yes

Drer\adgrl1a

4 of 15

Yes

Drer\adgrl4

4 of 15

Yes

Drer\LOC101884341

4 of 15

Yes

Drer\adgre5b.3

2 of 15

Yes

Drer\adgre7

2 of 15

Yes

Drer\adgre9

2 of 15

Yes

Drer\adgre10

2 of 15

Yes

Drer\adgre14

2 of 15

Yes

Drer\adgre15

2 of 15

Yes

Drer\adgrg1

2 of 15

Yes

Drer\adgrg2a

2 of 15

Yes

Drer\adgrg3

2 of 15

Yes

Drer\adgrg4a

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\LOC101886975

2 of 15

Yes

Drer\adgrb1a

1 of 15

Yes

Drer\adgrb2

1 of 15

Yes

Drer\adgrb3

1 of 15

Yes

Drer\adgrd2

1 of 15

Yes

Drer\adgre16

1 of 15

Yes

Drer\adgrf3a

1 of 15

Yes

Drer\adgrf6

1 of 15

Drer\adgrf7

1 of 15

Yes

Drer\adgrf8

1 of 15

Yes

Drer\adgrf11

1 of 15

Yes

Drer\adgrg7.1

1 of 15

Drer\adgrl1.1

1 of 15

Drer\adgrv1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\si:ch73-189n23.1

1 of 15

Drer\si:ch211-12h2.6

1 of 15

Drer\si:ch211-12h2.8

1 of 15

Drer\si:ch211-66i15.5

1 of 15

Drer\si:ch211-145c1.1

1 of 15

Drer\si:ch211-154a22.8

1 of 15

Drer\si:ch211-226h8.8

1 of 15

Drer\si:ch211-226h8.11

1 of 15

Drer\si:ch211-250e5.16

1 of 15

Drer\si:ch1073-75o15.4

1 of 15

Drer\si:dkey-90l23.1

1 of 15

Drer\si:dkey-240e12.6

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\lat-1

9 of 15

Yes

Cele\lat-2

6 of 15

Yes

Cele\mth-2

2 of 15

Yes

Cele\eva-1

1 of 15

Cele\fmi-1

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (23)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

mth

1 of 10

Pdfr

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

attention deficit hyperactivity disorder, susceptibility to (postulated), ADGRL3-related

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Cirl^KK108383

model of attention deficit hyperactivity disorder

CEA

(van der Voet et al., 2016)

Cirl^JF02674

model of attention deficit hyperactivity disorder

CEA

(van der Voet et al., 2016)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ADGRE2; adhesion G protein-coupled receptor E2

model of vibratory urticaria

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADGRL1; adhesion G protein-coupled receptor L1

10 of 15

616416

ADGRL3; adhesion G protein-coupled receptor L3

10 of 15

616417

ADGRL2; adhesion G protein-coupled receptor L2

9 of 15

607018

ADGRL4; adhesion G protein-coupled receptor L4

4 of 15

616419

ADGRE2; adhesion G protein-coupled receptor E2

3 of 15

606100

VIBRATORY URTICARIA; VBU

vibratory urticaria

ADGRE5; adhesion G protein-coupled receptor E5

3 of 15

601211

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cirl - Tollo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Lavalou et al., 2021)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.

(UniProt, A1Z7G7 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0033313

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0033313

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-59

Cytogenetic map

44D4-44D5

Sequence location

2R:8,614,722..8,625,203 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

44D4-44D5

Limits computationally determined from genome sequence between P{lacW}Rs1^k09514&P{lacW}l(2)k03110^k03110 and P{lacW}Vps25^k08904&P{lacW}ptc^k02507

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

44D-44E

(Lloyd et al., 2000)

Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.

(Lloyd et al., 2000)

Experimentally Determined Recombination Data

Location

2-59

(FlyBase, 2016)

2-57.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27524

y¹ v¹; P{TRiP.JF02674}attP2

93001

w^*; P{neoFRT}42D TI{TI}Cirl^N-RFP

21398

y¹ w^67c23; P{EPgy2}Cirl^EY12930

92999

y¹ w^*; P{neoFRT}42D Cirl^KO.attP.w+/CyO

91479

y¹ w^*; TI{CRIMIC.TG4.2}Cirl^{CR02244-TG4.2}/SM6a

93002

w^*; P{neoFRT}42D TI{TI}Cirl^N-RFP, P{tubP-GAL80}LL2/CyO

34821

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00136}attP2

93000

y¹ w^*; P{neoFRT}42D Cirl^KO.attP.w+, P{tubP-GAL80}LL2/CyO

VDRC

v100749

P{KK108383}VIE-260B

v29969

w¹¹¹⁸; P{GD14785}v29969

v318773

PBac{fTRG01155.sfGFP-TVPTBF}VK00033

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (152)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI14839

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0033313

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0033313

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

35846

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Scholz et al., 2015)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Cirl CG8639

(Verstreken and Bellen, 2000.9.4)

Source for database merge of

Source for merge of: Cirl BcDNA:GH07331

(FlyBase, 1996-)

Source for merge of: Cirl anon-WO0170980.7 anon-WO0170980.8

(FlyBase, 1996-)

Additional comments

Source for merge of Cirl BcDNA:GH07331 was a shared cDNA ( date:020730 ).

(FlyBase, 1996-)

Source for merge of Cirl anon-WO0170980.7 anon-WO0170980.8 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 67 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35846

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A1Z7G7

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

A1Z7G7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A1Z7G7

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0033313

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35846/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033313

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033313

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033313

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8639

Flygut - An atlas of the Drosophila adult midgut

FBgn0033313

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0033313

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

35846

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034516

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG8639

MARRVEL_MODEL - MARRVEL (model organism gene)

35846

modMine - A data warehouse for the modENCODE project

FBgn0033313

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0033313

DRSC - Results frm RNAi screens

FBgn0033313

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0033313

FlyMine - An integrated database for Drosophila genomics

FBgn0033313

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

ADGRL3

(Dalla Vecchia et al., 2019)

BcDNA:GH07331

CG8639

(Scholz et al., 2015, Li et al., 2013, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Metpally and Sowdhamini, 2005, Song et al., 2003, Harmar, 2001, Vanden Broeck, 2001, Brody and Cravchik, 2000)

CIRL

(Dannhäuser et al., 2020, Lloyd et al., 2000)

Cirl

(Evans et al., 2021, Lavalou et al., 2021, Liu et al., 2021, Saad and Hipfner, 2021, Aboukilila et al., 2020, Watanabe et al., 2020, Meltzer et al., 2019, Moreno-Salinas et al., 2019, Gene Disruption Project members, 2018-, Lou et al., 2017, Sarov et al., 2016, Scholz et al., 2015, Terriente-Felix et al., 2013, Younger et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Tan et al., 2012, Friedman et al., 2011, Krejcí et al., 2009)

anon-WO0170980.7

anon-WO0170980.8

dCirl

(Scholz et al., 2019, Scholz et al., 2017, Scholz et al., 2015)

dcirl

(Song et al., 2003)

Name Synonyms

Calcium-independent receptor for α-latrotoxin

Cirl

Latrophilin

(Scholz et al., 2015)

latrophilin