FB2020_06, released Dec 22, 2020

Gene: Dmel\Cirl

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General Information
Symbol
Dmel\Cirl
Species
D. melanogaster
Name
Calcium-independent receptor for α-latrotoxin
Annotation Symbol
CG8639
Feature Type
protein_coding_gene
FlyBase ID
FBgn0033313
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

dCirl, latrophilin

Key Links
Genomic Location
Cytogenetic map
44D4-44D5
Sequence location
2R:8,614,722..8,625,203 [+]
Recombination map

2-59

RefSeq locus
NT_033778 REGION:8614722..8625203
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables carbohydrate binding
inferred from electronic annotation with InterPro:IPR000922
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables G protein-coupled receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000244280
(assigned by GO_Central )
(Gaudet et al., 2011)
enables latrotoxin receptor activity
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Biological Process (6 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in adult locomotory behavior
inferred from mutant phenotype
(van der Voet et al., 2016)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000244280
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in cell surface receptor signaling pathway
inferred from electronic annotation with InterPro:IPR017981
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in G protein-coupled receptor signaling pathway
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
involved_in neurotransmitter secretion
non-traceable author statement
(Lloyd et al., 2000)
involved_in vesicle-mediated transport
non-traceable author statement
(Lloyd et al., 2000)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
located_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000244280
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in synaptic vesicle
non-traceable author statement
(Lloyd et al., 2000)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. (A1Z7G7)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CLASS B GPCRs, SUBFAMILY B2 -
The B2 subfamily of Class B GPCRs are characterized by a long extracellular N-terminal domain and a GPCR proteolytic site (GPS), which is located within a conserved sixty residue domain N-terminally to the first transmembrane domain. (Adapted from FBrf0147071 and FBrf0221117).
Summary (Interactive Fly)

G-protein coupled receptor - involved in the perception of tactile, proprioceptive, and auditory stimuli through chordotonal neurons of the PNS - sensitizes these neurons for the detection of mechanical stimulation by amplifying their input-output function

Gene Model and Products
Number of Transcripts
8
Number of Unique Polypeptides
6

Please see the JBrowse view of Dmel\Cirl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.49

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cirl-RB
FBtr0290112
NM_001144148
6940
1643
Cirl-RE
FBtr0301363
NM_001169619
5860
1639
Cirl-RF
FBtr0305080
NM_001259275
3610
932
Cirl-RG
FBtr0305081
NM_136553
7571
1695
Cirl-RH
FBtr0305082
NM_001259276
7805
1643
Cirl-RI
FBtr0310448
NM_001273878
7631
1711
Cirl-RJ
FBtr0310449
NM_001273879
4305
1000
Cirl-RK
FBtr0310450
NM_001273880
4166
932
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cirl-PB
FBpp0288551
180.0
1643
7.09
NP_001137620
ACL83074
Cirl-PE
FBpp0290577
179.5
1639
7.05
NP_001163090
ACZ94369
Cirl-PF
FBpp0293617
101.6
932
8.20
NP_001246204
AFH07959
Cirl-PG
FBpp0293618
185.8
1695
7.06
NP_610397
AAF59067
Cirl-PH
FBpp0293619
180.0
1643
7.09
NP_001246205
AFH07960
Cirl-PI
FBpp0302596
187.6
1711
7.00
NP_001260807
AGB93340
Cirl-PJ
FBpp0302597
109.2
1000
7.85
NP_001260808
AGB93341
Cirl-PK
FBpp0302598
101.6
932
8.20
NP_001260809
AGB93342
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1643 aa isoforms: Cirl-PB, Cirl-PH
932 aa isoforms: Cirl-PF, Cirl-PK
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.

(UniProt, A1Z7G7)
Post Translational Modification

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.

(UniProt, A1Z7G7)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cirl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
larva
(Scholz et al., 2015)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cirl in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cirl
Transgenic constructs containing regulatory region of Cirl
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (27)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ADGRL1
10 of 15
Yes
Yes
Hsap\ADGRL3
10 of 15
Yes
Yes
Hsap\ADGRL2
9 of 15
No
Yes
Hsap\ADGRL4
4 of 15
No
Yes
Hsap\ADGRE2
3 of 15
No
Yes
Hsap\ADGRE5
3 of 15
No
Yes
Hsap\ADGRE1
2 of 15
No
Yes
Hsap\ADGRE3
2 of 15
No
Yes
Hsap\ADGRG1
2 of 15
No
Yes
Hsap\ADGRG2
2 of 15
No
No
Hsap\ADGRG3
2 of 15
No
No
Hsap\ADGRG4
2 of 15
No
No
Hsap\ADGRG5
2 of 15
No
Yes
Hsap\ADGRG6
2 of 15
No
No
Hsap\ADGRG7
2 of 15
No
No
Hsap\ADGRB1
1 of 15
No
Yes
Hsap\ADGRB2
1 of 15
No
Yes
Hsap\ADGRB3
1 of 15
No
Yes
Hsap\ADGRD1
1 of 15
No
Yes
Hsap\ADGRD2
1 of 15
No
Yes
Hsap\ADGRE4P
1 of 15
No
Yes
Hsap\ADGRF1
1 of 15
No
No
Hsap\ADGRF2
1 of 15
No
Yes
Hsap\ADGRF3
1 of 15
No
Yes
Hsap\ADGRF4
1 of 15
No
Yes
Hsap\ADGRF5
1 of 15
No
No
Hsap\EVA1C
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (24)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Adgrl1
11 of 15
Yes
Yes
Mmus\Adgrl2
9 of 15
No
Yes
Mmus\Adgrl3
9 of 15
No
Yes
Mmus\Adgrl4
4 of 15
No
Yes
Mmus\Adgre1
3 of 15
No
Yes
Mmus\Adgre4
2 of 15
No
Yes
Mmus\Adgre5
2 of 15
No
Yes
Mmus\Adgrg1
2 of 15
No
No
Mmus\Adgrg2
2 of 15
No
No
Mmus\Adgrg3
2 of 15
No
No
Mmus\Adgrg5
2 of 15
No
No
Mmus\Adgrg6
2 of 15
No
No
Mmus\Adgrg7
2 of 15
No
No
Mmus\Adgrb1
1 of 15
No
Yes
Mmus\Adgrb2
1 of 15
No
Yes
Mmus\Adgrb3
1 of 15
No
Yes
Mmus\Adgrd1
1 of 15
No
Yes
Mmus\Adgrf1
1 of 15
No
No
Mmus\Adgrf2
1 of 15
No
Yes
Mmus\Adgrf3
1 of 15
No
Yes
Mmus\Adgrf4
1 of 15
No
Yes
Mmus\Adgrf5
1 of 15
No
No
Mmus\Adgrg4
1 of 15
No
No
Mmus\Eva1c
1 of 15
No
No
Rattus norvegicus (Norway rat) (21)
Rnor\Adgrl2
9 of 13
Yes
Yes
Rnor\Adgrl1
6 of 13
No
Yes
Rnor\Adgrl3
6 of 13
No
Yes
Rnor\Adgre1
3 of 13
No
Yes
Rnor\Adgre5
3 of 13
No
Yes
Rnor\Adgrl4
3 of 13
No
Yes
Rnor\Adgrg2
2 of 13
No
No
Rnor\Adgrg3
2 of 13
No
Yes
Rnor\Adgrg5
2 of 13
No
Yes
Rnor\Adgrg6
2 of 13
No
No
Rnor\Adgrg7
2 of 13
No
No
Rnor\Adgrb2
1 of 13
No
Yes
Rnor\Adgrb3
1 of 13
No
Yes
Rnor\Adgrd1
1 of 13
No
Yes
Rnor\Adgre4
1 of 13
No
Yes
Rnor\Adgrf2
1 of 13
No
Yes
Rnor\Adgrf3
1 of 13
No
Yes
Rnor\Adgrf4
1 of 13
No
Yes
Rnor\Adgrf5
1 of 13
No
Yes
Rnor\Adgrg1
1 of 13
No
Yes
Rnor\Eva1c
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\adgrl1
3 of 12
Yes
Yes
Xtro\adgrg1
2 of 12
No
Yes
Xtro\adgrd1
1 of 12
No
Yes
Xtro\adgre1
1 of 12
No
Yes
Xtro\adgre5
1 of 12
No
Yes
Xtro\adgrf1
1 of 12
No
Yes
Xtro\adgrf3
1 of 12
No
Yes
Xtro\adgrl2
1 of 12
No
Yes
Xtro\adgrl3
1 of 12
No
Yes
Xtro\adgrv1
1 of 12
No
Yes
Xtro\eva1c
1 of 12
No
No
Xtro\LOC100498069
1 of 12
No
Yes
Danio rerio (Zebrafish) (65)
Drer\adgrl2a
9 of 15
Yes
Yes
Drer\adgrl3.1
6 of 15
No
Yes
Drer\LOC100535070
5 of 15
No
Yes
Drer\adgre5b.2
4 of 15
No
Yes
Drer\adgrl1a
4 of 15
No
Yes
Drer\adgrl4
4 of 15
No
Yes
Drer\LOC101884341
4 of 15
No
Yes
Drer\adgre5b.3
2 of 15
No
Yes
Drer\adgre7
2 of 15
No
Yes
Drer\adgre9
2 of 15
No
Yes
Drer\adgre10
2 of 15
No
Yes
Drer\adgre14
2 of 15
No
Yes
Drer\adgre15
2 of 15
No
Yes
Drer\adgrg1
2 of 15
No
Yes
Drer\adgrg2a
2 of 15
No
Yes
Drer\adgrg3
2 of 15
No
Yes
Drer\adgrg4a
2 of 15
No
Yes
Drer\adgrg6
2 of 15
No
No
Drer\adgrg11
2 of 15
No
No
Drer\adgrl2b.1
2 of 15
No
No
Drer\LOC100536657
2 of 15
No
Yes
Drer\LOC101886975
2 of 15
No
Yes
Drer\adgrb1a
1 of 15
No
Yes
Drer\adgrb2
1 of 15
No
Yes
Drer\adgrb3
1 of 15
No
Yes
Drer\adgrd2
1 of 15
No
Yes
Drer\adgre16
1 of 15
No
Yes
Drer\adgrf3a
1 of 15
No
Yes
Drer\adgrf6
1 of 15
No
No
Drer\adgrf7
1 of 15
No
Yes
Drer\adgrf8
1 of 15
No
Yes
Drer\adgrf11
1 of 15
No
Yes
Drer\adgrg7.1
1 of 15
No
No
Drer\adgrl1.1
1 of 15
No
No
Drer\adgrv1
1 of 15
No
Yes
Drer\eva1c
1 of 15
No
No
Drer\LOC564755
1 of 15
No
No
Drer\LOC100331830
1 of 15
No
No
Drer\LOC100331909
1 of 15
No
No
Drer\LOC100535847
1 of 15
No
No
Drer\LOC101882949
1 of 15
No
No
Drer\LOC101883602
1 of 15
No
No
Drer\LOC101884937
1 of 15
No
Yes
Drer\si:ch73-189n23.1
1 of 15
No
No
Drer\si:ch211-12h2.6
1 of 15
No
No
Drer\si:ch211-12h2.8
1 of 15
No
No
Drer\si:ch211-66i15.5
1 of 15
No
No
Drer\si:ch211-145c1.1
1 of 15
No
No
Drer\si:ch211-154a22.8
1 of 15
No
No
Drer\si:ch211-226h8.8
1 of 15
No
No
Drer\si:ch211-226h8.11
1 of 15
No
No
Drer\si:ch211-250e5.16
1 of 15
No
No
Drer\si:ch1073-75o15.4
1 of 15
No
No
Drer\si:dkey-90l23.1
1 of 15
No
No
Drer\si:dkey-240e12.6
1 of 15
No
No
Drer\si:dkeyp-46h3.2
1 of 15
No
No
Drer\si:dkeyp-46h3.8
1 of 15
No
No
Drer\si:dkeyp-98a7.4
1 of 15
No
No
Drer\si:dkeyp-98a7.5
1 of 15
No
No
Drer\si:dkeyp-98a7.7
1 of 15
No
No
Drer\si:dkeyp-98a7.8
1 of 15
No
No
Drer\zgc:136410
1 of 15
No
No
Drer\zgc:153499
1 of 15
No
No
Drer\zgc:171717
1 of 15
No
No
Drer\zgc:171776
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\lat-1
9 of 15
Yes
Yes
Cele\lat-2
6 of 15
No
Yes
Cele\mth-2
2 of 15
No
Yes
Cele\eva-1
1 of 15
No
No
Cele\fmi-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919014J )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006777
Drosophila simulans
Dsim\GD10581
Drosophila sechellia
Dsec\GM21049
Drosophila erecta
Dere\GG23370
Drosophila yakuba
Dyak\GE19213
Drosophila ananassae
Dana\GF12369
Drosophila pseudoobscura pseudoobscura
Dpse\GA21229
Drosophila persimilis
Dper\GL10904
Drosophila willistoni
Dwil\GK21728
Drosophila virilis
Dvir\GJ21826
Drosophila mojavensis
Dmoj\GI18798
Drosophila grimshawi
Dgri\GH20083
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500NI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17009247
Glossina morsitans
Tsetse fly
Gmor\GMOY007634
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09901
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04058
Mayetiola destructor
Hessian fly
Mdes\Mdes001187
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRCIR
Anopheles darlingi
American malaria mosquito
Adar\ADAC003710
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007249
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0159 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005714
Danaus plexippus
Monarch butterfly
Dple\DPOGS208591-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016581
Apis florea
Little honeybee
Aflo\2147848211
Apis mellifera
Western honey bee
Amel\GB51611
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16874
Bombus terrestris
Buff-tailed bumblebee
Bter\15212119
Linepithema humile
Argentine ant
Lhum\LH24976
Linepithema humile
Argentine ant
Lhum\LH24977
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002291
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG029133
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03290
Tribolium castaneum
Red flour beetle
Tcas\TC034516
Pediculus humanus
Human body louse
Phum\PHUM461700
Rhodnius prolixus
Kissing bug
Rpro\RPRC003850
Rhodnius prolixus
Kissing bug
Rpro\RPRC000159
Rhodnius prolixus
Kissing bug
Rpro\RPRC011885
Cimex lectularius
Bed bug
Clec\CLEC007943
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005705
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14083
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00QQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006024
Strigamia maritima
European centipede
Smar\SMAR011200
Ixodes scapularis
Black-legged tick
Isca\ISCW012721
Ixodes scapularis
Black-legged tick
Isca\ISCW000464
Ixodes scapularis
Black-legged tick
Isca\ISCW019673
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72959.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61762.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59022.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g05800
Tetranychus urticae
Two-spotted spider mite
Turt\tetur12g01350
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g00150
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g00190
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_101007
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_216409
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01O6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Clect/Scop/7Tm
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lnb/Tm7_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gal/Lect/Lnb/7Tm/Gpcr_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sr/Fa58c/Lnb/7Tm/Gpcr
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lphn1L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gpr133_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_1864
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gpr133
Ciona intestinalis
Vase tunicate
Cint\LOC494390
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (23)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG11318
3 of 10
CG15556
3 of 10
CG42402
2 of 10
mthl1
2 of 10
mthl6
2 of 10
mthl7
2 of 10
mthl12
2 of 10
mthl13
2 of 10
CG15744
1 of 10
CG43968
1 of 10
Dh44-R1
1 of 10
Dh44-R2
1 of 10
mthl2
1 of 10
mthl3
1 of 10
mthl4
1 of 10
mthl5
1 of 10
mthl8
1 of 10
mthl9
1 of 10
mthl10
1 of 10
mthl11
1 of 10
mthl14
1 of 10
mth
1 of 10
Pdfr
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
ADGRE2; adhesion G protein-coupled receptor E2
model of  vibratory urticaria
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ADGRL1; adhesion G protein-coupled receptor L1
10 of 15
616416
      ADGRL3; adhesion G protein-coupled receptor L3
      10 of 15
      616417
          ADGRL2; adhesion G protein-coupled receptor L2
          9 of 15
          607018
              ADGRL4; adhesion G protein-coupled receptor L4
              4 of 15
              616419
                  ADGRE2; adhesion G protein-coupled receptor E2
                  3 of 15
                  606100
                  ADGRE5; adhesion G protein-coupled receptor E5
                  3 of 15
                  601211
                      Functional Complementation Data
                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                      Interactions
                      Summary of Physical Interactions
                      esyN Network Diagram
                      Interactions Browser
                      Summary of Genetic Interactions
                      esyN Network Diagram
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      External Data
                      Subunit Structure (UniProtKB)
                      Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.
                      (UniProt, A1Z7G7 )
                      Linkouts
                      DroID - A comprehensive database of gene and protein interactions.
                      Pathways
                      Signaling Pathways (FlyBase)
                      Metabolic Pathways
                      External Data
                      Linkouts
                      Genomic Location and Detailed Mapping Data
                      Chromosome (arm)
                      2R
                      Recombination map

                      2-59

                      Cytogenetic map
                      44D4-44D5
                      Sequence location
                      2R:8,614,722..8,625,203 [+]
                      FlyBase Computed Cytological Location
                      Cytogenetic map
                      Evidence for location
                      44D4-44D5
                      Limits computationally determined from genome sequence between P{lacW}Rs1k09514&P{lacW}l(2)k03110k03110 and P{lacW}Vps25k08904&P{lacW}ptck02507
                      Experimentally Determined Cytological Location
                      Cytogenetic map
                      Notes
                      References
                      44D-44E
                      (Lloyd et al., 2000)
                      Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.
                      (Lloyd et al., 2000)
                      Experimentally Determined Recombination Data
                      Location

                      2-59

                      (FlyBase, 2016)

                      2-57.8

                      (Comeron et al., 2012)
                      Left of (cM)
                      Right of (cM)
                      Notes
                      Stocks and Reagents
                      Stocks (6)
                      Genomic Clones (21)
                      cDNA Clones (152)
                       

                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                      cDNA clones, fully sequenced
                      BDGP DGC clones
                      Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      Antibody Information
                      Laboratory Generated Antibodies
                       

                      polyclonal

                      (Scholz et al., 2015)
                      Commercially Available Antibodies
                       
                      Other Information
                      Relationship to Other Genes
                      Source for database identify of

                      Source for identity of: Cirl CG8639

                      (Verstreken and Bellen, 2000.9.4)
                      Source for database merge of

                      Source for merge of: Cirl BcDNA:GH07331

                      (FlyBase, 1996-)

                      Source for merge of: Cirl anon-WO0170980.7 anon-WO0170980.8

                      (FlyBase, 1996-)
                      Additional comments

                      Source for merge of Cirl BcDNA:GH07331 was a shared cDNA ( date:020730 ).

                      (FlyBase, 1996-)

                      Source for merge of Cirl anon-WO0170980.7 anon-WO0170980.8 was sequence comparison ( date:051113 ).

                      (FlyBase, 1996-)
                      Other Comments

                      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                      (Kiger et al., 2003)
                      Origin and Etymology
                      Discoverer
                      Etymology
                      Identification
                      External Crossreferences and Linkouts ( 59 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      modMine - A data warehouse for the modENCODE project
                      Linkouts
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      FlyMine - An integrated database for Drosophila genomics
                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                      Synonyms and Secondary IDs (12)
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      References (62)