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Gene Dmel\CG8232

General Information
Symbol	Dmel\CG8232	Species	D. melanogaster
Name		Annotation symbol	CG8232
Feature type	protein_coding_gene	FlyBase ID	FBgn0033352
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	PAN2
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	44F8-44F9	Sequence location	2R:4,815,674..4,820,608 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG8232 (FBgn0033352). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: nuclear-transcribed mRNA poly(A) tail shortening. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Exonuclease; Exonuclease, RNase T/DNA polymerase III; Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2; Ribonuclease H-like domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules, larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636801_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG8232. Gene sequence location is 2R:4815674..4820608.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 44F8-44F9   Limits computationally determined from genome sequence between P{lacW}Dmnk16109&P{lacW}Gγ1k08017 and P{lacW}babok16912
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG8232 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG8232-RA FBtr0088654  NM_136583   4051   1241 CG8232-RB FBtr0339303     4048   1240
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG8232-PA   FBpp0087735   139.0   1241   5.98     NP_610427   AAF59018 CG8232-PB   FBpp0308411   138.9   1240   6.04
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40-repeat-containing domain (IPR017986) Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (IPR001394) Exonuclease (IPR006055) Ribonuclease H-like domain (IPR012337) Exonuclease, RNase T/DNA polymerase III (IPR013520) WD40/YVTN repeat-like-containing domain (IPR015943)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201976   AA201977   AA202111   AA391531   AA817074   AA941071   AA949122   AA949855   AE013599 AAF59018   AI295217   AI386928   AI387219   AI455236   AI512244   AI515367   AI516001   AI518057   AI518806   AI519534   AI520265   AI531435   AI534128   AI542192   AI543143   AI543498   AY095049 AAM11377   AY119601 AAM50255   BF493056   BF493057   BF504564   BG638575   BI162830   BI163152   BI163577   BI164371   BI164382   BI164860   BI165787   BI170821   BI214524   BI230331   BI231930   BI234177   BI236503   BI238929   BI375727   BI482320   BI580423   BI637320   BI637748   BI638905   BI639556   BI639672   BI640837   BI641623   BT031142   CA807838   CK657713   CK658307   CK661282   CO184030   CO271197   CO274992   CO321828   CO323640   CO326947   CO332571   CZ482620   EC062599   EC062858   EC067831   EC077999   EC208867   EC258015   EC259090   ES690263   EV587233   EV587669
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z7K9 Q8SWW0 Q8MRI7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules, larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    388.85 Larval Midgut    352.5 Larval Hindgut    396.3 Larval Malpighian Tubules    963.6 Larval Fat Body    283.8 Larval Salivary Gland    777.9 Larval Trachea    312.55 Larval Carcass    259.975 Adult Head    222.7 Adult Eye    211.8 Adult Brain    239.4 Adult Thoracic-Abdominal Ganglion    229.1 Adult Crop    379.2 Adult Midgut    286.6 Adult Hindgut    346.1 Adult Malpighian Tubules    478.1 Adult Fat Body    233.3 Adult Salivary Gland    688.5 Adult Heart    179.25 Adult VirginFemale Spermatheca    253.4 Adult InseminatedFemale Spermatheca    194.9 Adult Ovary    294.1 Adult Testis    92.1 Adult Male Accessory Gland    321.4 Adult Carcass    203.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    388.85 Larval Midgut    352.5 Larval Hindgut    396.3 Larval Malpighian Tubules  (963.6) Larval Fat Body    283.8 Larval Salivary Gland  (777.9) Larval Trachea    312.55 Larval Carcass    259.975 Adult Head    222.7 Adult Eye    211.8 Adult Brain    239.4 Adult Thoracic-Abdominal Ganglion    229.1 Adult Crop    379.2 Adult Midgut    286.6 Adult Hindgut    346.1 Adult Malpighian Tubules    478.1 Adult Fat Body    233.3 Adult Salivary Gland  (688.5) Adult Heart    179.25 Adult VirginFemale Spermatheca    253.4 Adult InseminatedFemale Spermatheca    194.9 Adult Ovary    294.1 Adult Testis    92.1 Adult Male Accessory Gland    321.4 Adult Carcass    203.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    388.85 Larval Midgut    352.5 Larval Hindgut    396.3 Larval Malpighian Tubules    963.6 Larval Fat Body    283.8 Larval Salivary Gland    777.9 Larval Trachea    312.55 Larval Carcass    259.975 Adult Head    222.7 Adult Eye    211.8 Adult Brain    239.4 Adult Thoracic-Abdominal Ganglion    229.1 Adult Crop    379.2 Adult Midgut    286.6 Adult Hindgut    346.1 Adult Malpighian Tubules    478.1 Adult Fat Body    233.3 Adult Salivary Gland    688.5 Adult Heart    179.25 Adult VirginFemale Spermatheca    253.4 Adult InseminatedFemale Spermatheca    194.9 Adult Ovary    294.1 Adult Testis    92.1 Adult Male Accessory Gland    321.4 Adult Carcass    203.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    388.85 Larval Midgut    352.5 Larval Hindgut    396.3 Larval Malpighian Tubules    963.6 Larval Fat Body    283.8 Larval Salivary Gland    777.9 Larval Trachea    312.55 Larval Carcass    259.975 Adult Head    222.7 Adult Eye    211.8 Adult Brain    239.4 Adult Thoracic-Abdominal Ganglion    229.1 Adult Crop    379.2 Adult Midgut    286.6 Adult Hindgut    346.1 Adult Malpighian Tubules    478.1 Adult Fat Body    233.3 Adult Salivary Gland    688.5 Adult Heart    179.25 Adult VirginFemale Spermatheca    253.4 Adult InseminatedFemale Spermatheca    194.9 Adult Ovary    294.1 Adult Testis    92.1 Adult Male Accessory Gland    321.4 Adult Carcass    203.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    388.85 Larval Midgut    352.5 Larval Hindgut    396.3 Larval Malpighian Tubules    963.6 Larval Fat Body    283.8 Larval Salivary Gland    777.9 Larval Trachea    312.55 Larval Carcass    259.975 Adult Head    222.7 Adult Eye    211.8 Adult Brain    239.4 Adult Thoracic-Abdominal Ganglion    229.1 Adult Crop    379.2 Adult Midgut    286.6 Adult Hindgut    346.1 Adult Malpighian Tubules    478.1 Adult Fat Body    233.3 Adult Salivary Gland    688.5 Adult Heart    179.25 Adult VirginFemale Spermatheca    253.4 Adult InseminatedFemale Spermatheca    194.9 Adult Ovary    294.1 Adult Testis    92.1 Adult Male Accessory Gland    321.4 Adult Carcass    203.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    388.85 Larval Midgut    352.5 Larval Hindgut    396.3 Larval Malpighian Tubules  (963.6) Larval Fat Body    283.8 Larval Salivary Gland  777.9 Larval Trachea    312.55 Larval Carcass    259.975 Adult Head    222.7 Adult Eye    211.8 Adult Brain    239.4 Adult Thoracic-Abdominal Ganglion    229.1 Adult Crop    379.2 Adult Midgut    286.6 Adult Hindgut    346.1 Adult Malpighian Tubules    478.1 Adult Fat Body    233.3 Adult Salivary Gland  688.5 Adult Heart    179.25 Adult VirginFemale Spermatheca    253.4 Adult InseminatedFemale Spermatheca    194.9 Adult Ovary    294.1 Adult Testis    92.1 Adult Male Accessory Gland    321.4 Adult Carcass    203.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    388.85 Larval Midgut    352.5 Larval Hindgut    396.3 Larval Malpighian Tubules    963.6 Larval Fat Body    283.8 Larval Salivary Gland    777.9 Larval Trachea    312.55 Larval Carcass    259.975 Adult Head    222.7 Adult Eye    211.8 Adult Brain    239.4 Adult Thoracic-Abdominal Ganglion    229.1 Adult Crop    379.2 Adult Midgut    286.6 Adult Hindgut    346.1 Adult Malpighian Tubules    478.1 Adult Fat Body    233.3 Adult Salivary Gland    688.5 Adult Heart    179.25 Adult VirginFemale Spermatheca    253.4 Adult InseminatedFemale Spermatheca    194.9 Adult Ovary    294.1 Adult Testis    92.1 Adult Male Accessory Gland    321.4 Adult Carcass    203.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    388.85 Larval Midgut    352.5 Larval Hindgut    396.3 Larval Malpighian Tubules    963.6 Larval Fat Body    283.8 Larval Salivary Gland    777.9 Larval Trachea    312.55 Larval Carcass    259.975 Adult Head    222.7 Adult Eye    211.8 Adult Brain    239.4 Adult Thoracic-Abdominal Ganglion    229.1 Adult Crop    379.2 Adult Midgut    286.6 Adult Hindgut    346.1 Adult Malpighian Tubules    478.1 Adult Fat Body    233.3 Adult Salivary Gland    688.5 Adult Heart    179.25 Adult VirginFemale Spermatheca    253.4 Adult InseminatedFemale Spermatheca    194.9 Adult Ovary    294.1 Adult Testis    92.1 Adult Male Accessory Gland    321.4 Adult Carcass    203.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    222.7   NA  Eye    211.8   NA  Brain    239.4   388.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    229.1   NA  Crop    379.2   352.5  Midgut    286.6   396.3  Hindgut    346.1   963.6  Malpighian Tubules    478.1   283.8  Fat Body    233.3   777.9  Salivary Gland    688.5   NA  Heart    179.25   312.55  Trachea    NA   NA  VirginFemale Spermatheca    253.4   NA  InseminatedFemale Spermatheca    194.9   NA  Ovary    294.1   NA  Testis    92.1   NA  Male Accessory Gland    321.4   259.975  Carcass    203.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    27 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    13 digestive system, 4-day adult    11 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    20 carcass, larvae L3 wandering    28 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    32 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (27) central nervous system, larvae L3  (27) central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    19 digestive system, larvae L3 wandering  (30) digestive system, 1-day adult    13 digestive system, 4-day adult    11 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    20 carcass, larvae L3 wandering  (28) carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female  (32) ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    27 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    13 digestive system, 4-day adult    11 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    20 carcass, larvae L3 wandering    28 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    32 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    27 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    13 digestive system, 4-day adult    11 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    20 carcass, larvae L3 wandering    28 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    32 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    27 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    13 digestive system, 4-day adult    11 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    20 carcass, larvae L3 wandering    28 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    32 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  27 central nervous system, larvae L3  27 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    19 digestive system, larvae L3 wandering  30 digestive system, 1-day adult    13 digestive system, 4-day adult    11 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    20 carcass, larvae L3 wandering  28 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female  32 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    27 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    13 digestive system, 4-day adult    11 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    20 carcass, larvae L3 wandering    28 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    32 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    27 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    13 digestive system, 4-day adult    11 digestive system, 20-day adult    16 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    20 carcass, larvae L3 wandering    28 carcass, 1-day adult    9 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    32 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    55 embryo 04-06hr    54 embryo 06-08hr    45 embryo 08-10hr    42 embryo 10-12hr    34 embryo 12-14hr    36 embryo 14-16hr    35 embryo 16-18hr    28 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    12 larva L2    15 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    35 white prepupae new    32 white prepupae 12hr    46 white prepupae 24hr    40 pupae 2d postWPP    33 pupae 3d postWPP    16 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    19 adult female 05day    26 adult female 30day    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (55) embryo 04-06hr  (54) embryo 06-08hr  (45) embryo 08-10hr  (42) embryo 10-12hr  (34) embryo 12-14hr  (36) embryo 14-16hr  (35) embryo 16-18hr  (28) embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    12 larva L2    15 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6  (30) larva L3 puffstage 7-9  (35) white prepupae new  (32) white prepupae 12hr  (46) white prepupae 24hr  (40) pupae 2d postWPP  (33) pupae 3d postWPP    16 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    19 adult female 05day  26 adult female 30day  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    55 embryo 04-06hr    54 embryo 06-08hr    45 embryo 08-10hr    42 embryo 10-12hr    34 embryo 12-14hr    36 embryo 14-16hr    35 embryo 16-18hr    28 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    12 larva L2    15 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    35 white prepupae new    32 white prepupae 12hr    46 white prepupae 24hr    40 pupae 2d postWPP    33 pupae 3d postWPP    16 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    19 adult female 05day    26 adult female 30day    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    55 embryo 04-06hr    54 embryo 06-08hr    45 embryo 08-10hr    42 embryo 10-12hr    34 embryo 12-14hr    36 embryo 14-16hr    35 embryo 16-18hr    28 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    12 larva L2    15 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    35 white prepupae new    32 white prepupae 12hr    46 white prepupae 24hr    40 pupae 2d postWPP    33 pupae 3d postWPP    16 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    19 adult female 05day    26 adult female 30day    26 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    55 embryo 04-06hr    54 embryo 06-08hr    45 embryo 08-10hr    42 embryo 10-12hr    34 embryo 12-14hr    36 embryo 14-16hr    35 embryo 16-18hr    28 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    12 larva L2    15 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    35 white prepupae new    32 white prepupae 12hr    46 white prepupae 24hr    40 pupae 2d postWPP    33 pupae 3d postWPP    16 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    19 adult female 05day    26 adult female 30day    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (55) embryo 04-06hr  (54) embryo 06-08hr  (45) embryo 08-10hr  (42) embryo 10-12hr  (34) embryo 12-14hr  (36) embryo 14-16hr  (35) embryo 16-18hr  28 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    12 larva L2    15 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6  30 larva L3 puffstage 7-9  (35) white prepupae new  32 white prepupae 12hr  (46) white prepupae 24hr  (40) pupae 2d postWPP  (33) pupae 3d postWPP    16 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    19 adult female 05day  26 adult female 30day  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    55 embryo 04-06hr    54 embryo 06-08hr    45 embryo 08-10hr    42 embryo 10-12hr    34 embryo 12-14hr    36 embryo 14-16hr    35 embryo 16-18hr    28 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    12 larva L2    15 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    35 white prepupae new    32 white prepupae 12hr    46 white prepupae 24hr    40 pupae 2d postWPP    33 pupae 3d postWPP    16 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    19 adult female 05day    26 adult female 30day    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    55 embryo 04-06hr    54 embryo 06-08hr    45 embryo 08-10hr    42 embryo 10-12hr    34 embryo 12-14hr    36 embryo 14-16hr    35 embryo 16-18hr    28 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    12 larva L2    15 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    35 white prepupae new    32 white prepupae 12hr    46 white prepupae 24hr    40 pupae 2d postWPP    33 pupae 3d postWPP    16 pupae 4d postWPP    10 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    19 adult female 05day    26 adult female 30day    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    32 embryonic 1182-4H    40 embryonic GM2    56 embryonic Kc167    32 embryonic S1    66 embryonic S3    42 leg disc CME L1    35 wing disc CME-W2    39 wing disc ML-DmD8    35 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    25 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    29 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    21 ovary fGS/OSS    46 ovary OSC    46 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (42) Schneider line 2 Sg4  (32) embryonic 1182-4H  (40) embryonic GM2  (56) embryonic Kc167  (32) embryonic S1  (66) embryonic S3  (42) leg disc CME L1  (35) wing disc CME-W2  (39) wing disc ML-DmD8  (35) wing disc ML-DmD9  (41) wing disc ML-DmD16-c3  (32) wing disc ML-DmD21    25 wing disc ML-DmD32  (32) haltere disc ML-DmD17-c3  (49) eye-antennal disc ML-DmD11  (29) antennal disc ML-DmD20-c5  (29) mixed discs ML-DmD4-c1  (29) CNS ML-DmBG1-c1  (38) CNS ML-DmBG2-c2  (60) tumorous blood cells mbn2    21 ovary fGS/OSS  (46) ovary OSC  (46) ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    32 embryonic 1182-4H    40 embryonic GM2    56 embryonic Kc167    32 embryonic S1    66 embryonic S3    42 leg disc CME L1    35 wing disc CME-W2    39 wing disc ML-DmD8    35 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    25 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    29 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    21 ovary fGS/OSS    46 ovary OSC    46 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    32 embryonic 1182-4H    40 embryonic GM2    56 embryonic Kc167    32 embryonic S1    66 embryonic S3    42 leg disc CME L1    35 wing disc CME-W2    39 wing disc ML-DmD8    35 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    25 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    29 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    21 ovary fGS/OSS    46 ovary OSC    46 ovary OSS    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    32 embryonic 1182-4H    40 embryonic GM2    56 embryonic Kc167    32 embryonic S1    66 embryonic S3    42 leg disc CME L1    35 wing disc CME-W2    39 wing disc ML-DmD8    35 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    25 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    29 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    21 ovary fGS/OSS    46 ovary OSC    46 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (42) Schneider line 2 Sg4  32 embryonic 1182-4H  (40) embryonic GM2  (56) embryonic Kc167  32 embryonic S1  (66) embryonic S3  (42) leg disc CME L1  (35) wing disc CME-W2  (39) wing disc ML-DmD8  (35) wing disc ML-DmD9  (41) wing disc ML-DmD16-c3  32 wing disc ML-DmD21    25 wing disc ML-DmD32  32 haltere disc ML-DmD17-c3  (49) eye-antennal disc ML-DmD11  29 antennal disc ML-DmD20-c5  29 mixed discs ML-DmD4-c1  29 CNS ML-DmBG1-c1  (38) CNS ML-DmBG2-c2  (60) tumorous blood cells mbn2    21 ovary fGS/OSS  (46) ovary OSC  (46) ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    32 embryonic 1182-4H    40 embryonic GM2    56 embryonic Kc167    32 embryonic S1    66 embryonic S3    42 leg disc CME L1    35 wing disc CME-W2    39 wing disc ML-DmD8    35 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    25 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    29 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    21 ovary fGS/OSS    46 ovary OSC    46 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    32 embryonic 1182-4H    40 embryonic GM2    56 embryonic Kc167    32 embryonic S1    66 embryonic S3    42 leg disc CME L1    35 wing disc CME-W2    39 wing disc ML-DmD8    35 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    25 wing disc ML-DmD32    32 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    29 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    60 tumorous blood cells mbn2    21 ovary fGS/OSS    46 ovary OSC    46 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    9 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    9 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    9 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    9 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    9 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    9 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    9 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    9 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    22 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    17 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033352 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4875-RA;CG8232-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG8232f00130 Sterility Allele fertile CG8232f00130 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG8232 Class Mutagen Stocks Known lesion CG8232f00130 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG8232 Class Mutagen Stocks Known lesion CG8232GD13851 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG8232NIG.8232R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel8048 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13851} NA P{NIG.8232R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}CG8232f00130 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with UniProtKB:Q8SY33 (assigned by UniProtKB) (Braun et al., 2011)
Biological Process
CV term Evidence References
nuclear-transcribed mRNA poly(A) tail shortening inferred from genetic interaction with Pop2 (Bönisch et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR012337 (FlyBase Curators et al., 2004-) poly(A)-specific ribonuclease activity inferred from sequence or structural similarity with Saccharomyces PAN2 (FlyBase, 1992-) ubiquitin thiolesterase activity inferred from electronic annotation with InterPro:IPR001394 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
ubiquitin-dependent protein catabolic process inferred from electronic annotation with InterPro:IPR001394 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR006055 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG8232 - CG11486 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG8232 - gw anti tag coimmunoprecipitation, anti tag western blot (Braun et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG8232 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61731 DroID - A comprehensive database of gene and protein interactions. • FBgn0033352 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35893
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6J9NJ7 Dipteran inclusive ortholog search EOG6S7JXZ Insect inclusive ortholog search EOG6DV4G3 Arthropod inclusive ortholog search EOG64B8H2 Metazoa inclusive ortholog search EOG65F8G3
Orthologs in Drosophila Species (EOG6J9NJ7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG8232     Drosophila sechellia   Dsec\GM21079 Y   Drosophila erecta   Dere\GG23399 Y   Drosophila yakuba   Dyak\GE19240 Y   Drosophila ananassae   Dana\GF12217 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20915 Y   Drosophila persimilis   Dper\GL11682 Y   Drosophila willistoni   Dwil\GK10644 Y   Drosophila virilis   Dvir\GJ21307 Y   Drosophila mojavensis   Dmoj\GI18935 Y   Drosophila grimshawi   Dgri\GH23112 Y
Orthologs in non-Drosophila Dipterans (EOG6S7JXZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005564   Anopheles gambiae Malaria mosquito  Agam\AGAP010626   Anopheles gambiae Malaria mosquito  Agam\AGAP012780   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005737
Orthologs in non-Dipteran Insects (EOG6DV4G3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC724505   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009631   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20345   Atta cephalotes Leafcutter ant  Acep\ACEP25234   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14450   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14945   Linepithema humile Argentine ant  Lhum\LH16564   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20823   Solenopsis invicta Red fire ant  Sinv\SINV13564   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004478   Bombyx mori Silkmoth  Bmor\BGIBMGA005275   Bombyx mori Silkmoth  Bmor\BGIBMGA005276   Pediculus humanus Human body louse  Phum\PHUM614080   Tribolium castaneum Red flour beetle  Tcas\TC006714
Orthologs in non-Insect Arthropods (EOG64B8H2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Fetub   Ixodes scapularis Deer tick  Isca\ISCW019107
Orthologs in non-Arthropod Metazoa (EOG65F8G3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F31E3.4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017065gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020437gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003537gn   Danio rerio Zebrafish  Drer\pan2   Xenopus tropicalis Western clawed frog  Xtro\pan2   Gallus gallus Domestic chicken  Ggal\ENSGALG00000002779   Mus musculus House mouse  Mmus\Pan2   Rattus norvegicus Norway rat  Rnor\Pan2   Homo sapiens Human  Hsap\ENSG00000135473
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000135473
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10614 Drosophila sechellia Dsec\GM21079 Drosophila erecta Dere\GG23399 Drosophila yakuba Dyak\GE19240 Drosophila ananassae Dana\GF12217 Drosophila pseudoobscura pseudoobscura Dpse\GA20915 Drosophila persimilis Dper\GL11682 Drosophila willistoni Dwil\GK10644 Drosophila virilis Dvir\GJ21307 Drosophila mojavensis Dmoj\GI18935 Drosophila grimshawi Dgri\GH23112
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	18295 w1118; PBac{WH}CG8232f00130
Harvard	- PBac{WH}CG8232f00130
Genomic Clones ( 1 )
	BACR02C23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 70 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22095 LD37466 LP04771
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT06147 GH17317 GH17678 LD02220 LD04602 LD04603 LD10189 LD25023 LD27896 LD35205 LD39158 LD40366 LD41732 LD44020 LD47160 LP08782 LP15151 LP20664 LP24229 RE02071 RE02483 RE03011 RE04036 RE04048 RE04618 RE05745 RE10123 RE12416 RE20357 RE25112 RE29835 RE32566 RE35301 RE63593 RE64996 RE74616 SD02470 SD06644 SD08334 SD09760 SD10280 SD19301 SD19817 SD21309 SD22167 SD22318 SD23845 SD25066
Other clones	55762 59617 161750 214379.5 214537.49 276976 AT01327 CK01.143A.A6 Dmel_neb_013558_0109_2681 Dmel_neb_014630_0104_3057 EC26953 EK102308 EK116135 EK186459 EK191015 EK303926 EP05031 ESG019d.E21_F07 LD29903
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033352 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35893
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136583 RefSeq (Proteins) • NP_610427 DDBJ / EMBL / GenBank • AA817074 AAF59018 AAM11377 AAM50255 AI455236 AI518057 AY095049 AY119601 CZ482620 Entrez Gene - A searchable database of RefSeq genes. • 35893 UniProtKB/TrEMBL • A1Z7K9 Q8MRI7 Q8SWW0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40-repeat-containing domain (IPR017986) Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (IPR001394) Exonuclease (IPR006055) Ribonuclease H-like domain (IPR012337) Exonuclease, RNase T/DNA polymerase III (IPR013520) WD40/YVTN repeat-like-containing domain (IPR015943)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61731 DroID - A comprehensive database of gene and protein interactions. • FBgn0033352 DRSC - Results from RNAi screens. • FBgn0033352 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033352 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4875-RA;CG8232-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033352 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35893 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35893 modMine - Data generated by the modENCODE project. • FBgn0033352
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG8232 (Hoopfer et al., 2008, Han et al., 2011, Zhang et al., 2012, Wittkopp et al., 2008, Tsou et al., 2012, Japanese National Institute of Genetics, 2012.5.21) PAN2 (Bönisch et al., 2007, Lauwers et al., 2009) Pan2 (Bönisch et al., 2007) pan2 (Lauwers et al., 2009)
Name Synonym
Secondary FlyBase IDs
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Tsou et al., 2012, PLoS ONE 7(8): e43112 Systematic Analysis of the Physiological Importance of Deubiquitinating Enzymes. [FBrf0219256] Braun et al., 2011, Mol. Cell 44(1): 120--133 GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. [FBrf0216988] Han et al., 2011, Curr. Biol. 21(22): 1878--1887 The 3'-to-5' Exoribonuclease Nibbler Shapes the 3' Ends of MicroRNAs Bound to Drosophila Argonaute1. [FBrf0216729] Show all research papers ...