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Gene Dmel\proPO45

General Information
Symbol	Dmel\proPO45	Species	D. melanogaster
Name	prophenoloxidase 45	Annotation symbol	CG8193
Feature type	protein_coding_gene	FlyBase ID	FBgn0033367
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	PPO2, proPO45, PO45
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	45A1-45A1	Sequence location	2R:4,929,766..4,932,214 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene prophenoloxidase 45 is referred to in FlyBase by the symbol Dmel\proPO45 (CG8193, FBgn0033367). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: L-DOPA monooxygenase activity; dopamine monooxygenase activity. It is reported to be involved in the biological process: dopamine metabolic process. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Hemocyanin, C-terminal; Hemocyanin, N-terminal; Hemocyanin/hexamerin; Hemocyanin/hexamerin middle domain; Immunoglobulin E-set; Tyrosinase; Uncharacterised domain, di-copper centre. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages, during late larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult heart, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, larval hindgut, larval/adult fat body, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1633048_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG8193. Gene sequence location is 2R:4929766..4932214.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 45A1-45A1   Limits computationally determined from genome sequence between P{lacW}babok16912 and P{lacW}l(2)k16529k16529
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\proPO45 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) proPO45-RA FBtr0088663  NM_136599   2280   684
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein proPO45-PA   FBpp0087744   79.3   684   6.97     NP_610443   AAF59001
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Hemocyanin/hexamerin middle domain (IPR000896) Tyrosinase (IPR002227) Hemocyanin, C-terminal (IPR005203) Hemocyanin, N-terminal (IPR005204) Uncharacterised domain, di-copper centre (IPR008922) Hemocyanin/hexamerin (IPR013788) Immunoglobulin E-set (IPR014756)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF59001   AB055857   AI108746   AI257599   AI388255   AI514688   AI514690   AW940287   AY060652 AAL28200   AY061624   BI216016   BI238655   BI243941   BI358080   BI365011   BI483149   BI485347   BI485752   BI563706   BI580791   BI584395   BI586671   BI604316   BI613202   BI616866   BI619441   BI620487   BI620517   BI627370   BI627442   CK657283   CO180971   CO186192   CO269060   CO299787   CO303402   CO307505   CO331176   CO339197   CO343598   EC088993   EC194501   EC197206   EC240406   EC258499   EC260004   GH942916   GH945690   GH947039   GH949863   GH957027   GH967392   GH978006
UniProtKB/Swiss-Prot	Q9V521
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   procrystal cell   (Fisher et al., 2012) embryonic stage 13 -- 16   crystal cell   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004) extracellular space inferred from direct assay (Asano and Takebuchi, 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult heart, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, larval hindgut, larval/adult fat body, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    35.525 Larval Midgut    38.2 Larval Hindgut    144.4 Larval Malpighian Tubules    48.6 Larval Fat Body    169.8 Larval Salivary Gland    24.8 Larval Trachea    424.4 Larval Carcass    986.275 Adult Head    586.2 Adult Eye    88.275 Adult Brain    288.9 Adult Thoracic-Abdominal Ganglion    225.3 Adult Crop    39.3 Adult Midgut    24.5 Adult Hindgut    15.1 Adult Malpighian Tubules    18.4 Adult Fat Body    110.9 Adult Salivary Gland    34.5 Adult Heart    2006.975 Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    41.1 Adult Ovary    14.2 Adult Testis    94.4 Adult Male Accessory Gland    20 Adult Carcass    729.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    35.525 Larval Midgut    38.2 Larval Hindgut    144.4 Larval Malpighian Tubules    48.6 Larval Fat Body    169.8 Larval Salivary Gland    24.8 Larval Trachea    424.4 Larval Carcass  (986.275) Adult Head  (586.2) Adult Eye    88.275 Adult Brain    288.9 Adult Thoracic-Abdominal Ganglion    225.3 Adult Crop    39.3 Adult Midgut    24.5 Adult Hindgut    15.1 Adult Malpighian Tubules    18.4 Adult Fat Body    110.9 Adult Salivary Gland    34.5 Adult Heart  (2006.975) Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    41.1 Adult Ovary    14.2 Adult Testis    94.4 Adult Male Accessory Gland    20 Adult Carcass  (729.1) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    35.525 Larval Midgut    38.2 Larval Hindgut    144.4 Larval Malpighian Tubules    48.6 Larval Fat Body    169.8 Larval Salivary Gland    24.8 Larval Trachea    424.4 Larval Carcass    986.275 Adult Head    586.2 Adult Eye    88.275 Adult Brain    288.9 Adult Thoracic-Abdominal Ganglion    225.3 Adult Crop    39.3 Adult Midgut    24.5 Adult Hindgut    15.1 Adult Malpighian Tubules    18.4 Adult Fat Body    110.9 Adult Salivary Gland    34.5 Adult Heart  (2006.975) Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    41.1 Adult Ovary    14.2 Adult Testis    94.4 Adult Male Accessory Gland    20 Adult Carcass    729.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    35.525 Larval Midgut    38.2 Larval Hindgut    144.4 Larval Malpighian Tubules    48.6 Larval Fat Body    169.8 Larval Salivary Gland    24.8 Larval Trachea    424.4 Larval Carcass    986.275 Adult Head    586.2 Adult Eye    88.275 Adult Brain    288.9 Adult Thoracic-Abdominal Ganglion    225.3 Adult Crop    39.3 Adult Midgut    24.5 Adult Hindgut    15.1 Adult Malpighian Tubules    18.4 Adult Fat Body    110.9 Adult Salivary Gland    34.5 Adult Heart    2006.975 Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    41.1 Adult Ovary    14.2 Adult Testis    94.4 Adult Male Accessory Gland    20 Adult Carcass    729.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    35.525 Larval Midgut    38.2 Larval Hindgut    144.4 Larval Malpighian Tubules    48.6 Larval Fat Body    169.8 Larval Salivary Gland    24.8 Larval Trachea    424.4 Larval Carcass    986.275 Adult Head    586.2 Adult Eye    88.275 Adult Brain    288.9 Adult Thoracic-Abdominal Ganglion    225.3 Adult Crop    39.3 Adult Midgut    24.5 Adult Hindgut    15.1 Adult Malpighian Tubules    18.4 Adult Fat Body    110.9 Adult Salivary Gland    34.5 Adult Heart    2006.975 Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    41.1 Adult Ovary    14.2 Adult Testis    94.4 Adult Male Accessory Gland    20 Adult Carcass    729.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    35.525 Larval Midgut    38.2 Larval Hindgut    144.4 Larval Malpighian Tubules    48.6 Larval Fat Body    169.8 Larval Salivary Gland    24.8 Larval Trachea    424.4 Larval Carcass  (986.275) Adult Head  586.2 Adult Eye    88.275 Adult Brain    288.9 Adult Thoracic-Abdominal Ganglion    225.3 Adult Crop    39.3 Adult Midgut    24.5 Adult Hindgut    15.1 Adult Malpighian Tubules    18.4 Adult Fat Body    110.9 Adult Salivary Gland    34.5 Adult Heart  (2006.975) Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    41.1 Adult Ovary    14.2 Adult Testis    94.4 Adult Male Accessory Gland    20 Adult Carcass  729.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    35.525 Larval Midgut    38.2 Larval Hindgut    144.4 Larval Malpighian Tubules    48.6 Larval Fat Body    169.8 Larval Salivary Gland    24.8 Larval Trachea    424.4 Larval Carcass    986.275 Adult Head    586.2 Adult Eye    88.275 Adult Brain    288.9 Adult Thoracic-Abdominal Ganglion    225.3 Adult Crop    39.3 Adult Midgut    24.5 Adult Hindgut    15.1 Adult Malpighian Tubules    18.4 Adult Fat Body    110.9 Adult Salivary Gland    34.5 Adult Heart  (2006.975) Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    41.1 Adult Ovary    14.2 Adult Testis    94.4 Adult Male Accessory Gland    20 Adult Carcass    729.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    35.525 Larval Midgut    38.2 Larval Hindgut    144.4 Larval Malpighian Tubules    48.6 Larval Fat Body    169.8 Larval Salivary Gland    24.8 Larval Trachea    424.4 Larval Carcass    986.275 Adult Head    586.2 Adult Eye    88.275 Adult Brain    288.9 Adult Thoracic-Abdominal Ganglion    225.3 Adult Crop    39.3 Adult Midgut    24.5 Adult Hindgut    15.1 Adult Malpighian Tubules    18.4 Adult Fat Body    110.9 Adult Salivary Gland    34.5 Adult Heart    2006.975 Adult VirginFemale Spermatheca    55 Adult InseminatedFemale Spermatheca    41.1 Adult Ovary    14.2 Adult Testis    94.4 Adult Male Accessory Gland    20 Adult Carcass    729.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    586.2   NA  Eye    88.275   NA  Brain    288.9   35.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    225.3   NA  Crop    39.3   no informative data  Midgut    no informative data   144.4  Hindgut    no informative data   no informative data  Malpighian Tubules    no informative data   169.8  Fat Body    110.9   no informative data  Salivary Gland    no informative data   NA  Heart    2006.975   424.4  Trachea    NA   NA  VirginFemale Spermatheca    55   NA  InseminatedFemale Spermatheca    41.1   NA  Ovary    no informative data   NA  Testis    94.4   NA  Male Accessory Gland    no informative data   986.275  Carcass    729.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    19 head, virgin 4-day female    110 head, virgin 20-day female    39 head, mated 1-day female    43 head, mated 4-day female    117 head, mated 20-day female    70 head, mated 1-day male    24 head, mated 4-day male    164 head, mated 20-day male    54 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    13 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    32 carcass, 4-day adult    29 carcass, 20-day adult    4 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    19 head, virgin 4-day female  (110) head, virgin 20-day female  (39) head, mated 1-day female  (43) head, mated 4-day female  (117) head, mated 20-day female  (70) head, mated 1-day male    24 head, mated 4-day male  (164) head, mated 20-day male  (54) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    13 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult  (32) carcass, 4-day adult  (29) carcass, 20-day adult    4 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    19 head, virgin 4-day female  (110) head, virgin 20-day female    39 head, mated 1-day female    43 head, mated 4-day female  (117) head, mated 20-day female    70 head, mated 1-day male    24 head, mated 4-day male  (164) head, mated 20-day male    54 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    13 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    32 carcass, 4-day adult    29 carcass, 20-day adult    4 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    19 head, virgin 4-day female    110 head, virgin 20-day female    39 head, mated 1-day female    43 head, mated 4-day female    117 head, mated 20-day female    70 head, mated 1-day male    24 head, mated 4-day male    164 head, mated 20-day male    54 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    13 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    32 carcass, 4-day adult    29 carcass, 20-day adult    4 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    19 head, virgin 4-day female    110 head, virgin 20-day female    39 head, mated 1-day female    43 head, mated 4-day female    117 head, mated 20-day female    70 head, mated 1-day male    24 head, mated 4-day male    164 head, mated 20-day male    54 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    13 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    32 carcass, 4-day adult    29 carcass, 20-day adult    4 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    19 head, virgin 4-day female  (110) head, virgin 20-day female  (39) head, mated 1-day female  (43) head, mated 4-day female  (117) head, mated 20-day female  (70) head, mated 1-day male    24 head, mated 4-day male  (164) head, mated 20-day male  (54) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    13 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult  32 carcass, 4-day adult  29 carcass, 20-day adult    4 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    19 head, virgin 4-day female  110 head, virgin 20-day female    39 head, mated 1-day female    43 head, mated 4-day female  117 head, mated 20-day female    70 head, mated 1-day male    24 head, mated 4-day male  (164) head, mated 20-day male    54 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    13 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    32 carcass, 4-day adult    29 carcass, 20-day adult    4 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    19 head, virgin 4-day female    110 head, virgin 20-day female    39 head, mated 1-day female    43 head, mated 4-day female    117 head, mated 20-day female    70 head, mated 1-day male    24 head, mated 4-day male    164 head, mated 20-day male    54 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    13 digestive system, 4-day adult    3 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    32 carcass, 4-day adult    29 carcass, 20-day adult    4 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    8 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages, during late larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    3 embryo 06-08hr    27 embryo 08-10hr    49 embryo 10-12hr    91 embryo 12-14hr    80 embryo 14-16hr    132 embryo 16-18hr    85 embryo 18-20hr    15 embryo 20-22hr    6 embryo 22-24hr    5 larva L1    14 larva L2    40 larva L3 12hr old    35 larva L3 puffstage 1-2    158 larva L3 puffstage 3-6    82 larva L3 puffstage 7-9    19 white prepupae new    16 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    6 adult male 01day    6 adult male 05day    26 adult male 30day    10 adult female 01day    4 adult female 05day    6 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    3 embryo 06-08hr  (27) embryo 08-10hr  (49) embryo 10-12hr  (91) embryo 12-14hr  (80) embryo 14-16hr  (132) embryo 16-18hr  (85) embryo 18-20hr    15 embryo 20-22hr    6 embryo 22-24hr    5 larva L1    14 larva L2  (40) larva L3 12hr old  (35) larva L3 puffstage 1-2  (158) larva L3 puffstage 3-6  (82) larva L3 puffstage 7-9    19 white prepupae new    16 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    6 adult male 01day    6 adult male 05day  26 adult male 30day    10 adult female 01day    4 adult female 05day    6 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    3 embryo 06-08hr    27 embryo 08-10hr    49 embryo 10-12hr    91 embryo 12-14hr    80 embryo 14-16hr  (132) embryo 16-18hr    85 embryo 18-20hr    15 embryo 20-22hr    6 embryo 22-24hr    5 larva L1    14 larva L2    40 larva L3 12hr old    35 larva L3 puffstage 1-2  (158) larva L3 puffstage 3-6    82 larva L3 puffstage 7-9    19 white prepupae new    16 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    6 adult male 01day    6 adult male 05day    26 adult male 30day    10 adult female 01day    4 adult female 05day    6 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    3 embryo 06-08hr    27 embryo 08-10hr    49 embryo 10-12hr    91 embryo 12-14hr    80 embryo 14-16hr    132 embryo 16-18hr    85 embryo 18-20hr    15 embryo 20-22hr    6 embryo 22-24hr    5 larva L1    14 larva L2    40 larva L3 12hr old    35 larva L3 puffstage 1-2    158 larva L3 puffstage 3-6    82 larva L3 puffstage 7-9    19 white prepupae new    16 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    6 adult male 01day    6 adult male 05day    26 adult male 30day    10 adult female 01day    4 adult female 05day    6 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    3 embryo 06-08hr    27 embryo 08-10hr    49 embryo 10-12hr    91 embryo 12-14hr    80 embryo 14-16hr    132 embryo 16-18hr    85 embryo 18-20hr    15 embryo 20-22hr    6 embryo 22-24hr    5 larva L1    14 larva L2    40 larva L3 12hr old    35 larva L3 puffstage 1-2    158 larva L3 puffstage 3-6    82 larva L3 puffstage 7-9    19 white prepupae new    16 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    6 adult male 01day    6 adult male 05day    26 adult male 30day    10 adult female 01day    4 adult female 05day    6 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    3 embryo 06-08hr  27 embryo 08-10hr  (49) embryo 10-12hr  (91) embryo 12-14hr  (80) embryo 14-16hr  (132) embryo 16-18hr  (85) embryo 18-20hr    15 embryo 20-22hr    6 embryo 22-24hr    5 larva L1    14 larva L2  (40) larva L3 12hr old  (35) larva L3 puffstage 1-2  (158) larva L3 puffstage 3-6  (82) larva L3 puffstage 7-9    19 white prepupae new    16 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    6 adult male 01day    6 adult male 05day  26 adult male 30day    10 adult female 01day    4 adult female 05day    6 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    3 embryo 06-08hr    27 embryo 08-10hr    49 embryo 10-12hr    91 embryo 12-14hr    80 embryo 14-16hr  132 embryo 16-18hr    85 embryo 18-20hr    15 embryo 20-22hr    6 embryo 22-24hr    5 larva L1    14 larva L2    40 larva L3 12hr old    35 larva L3 puffstage 1-2  (158) larva L3 puffstage 3-6    82 larva L3 puffstage 7-9    19 white prepupae new    16 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    6 adult male 01day    6 adult male 05day    26 adult male 30day    10 adult female 01day    4 adult female 05day    6 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    3 embryo 06-08hr    27 embryo 08-10hr    49 embryo 10-12hr    91 embryo 12-14hr    80 embryo 14-16hr    132 embryo 16-18hr    85 embryo 18-20hr    15 embryo 20-22hr    6 embryo 22-24hr    5 larva L1    14 larva L2    40 larva L3 12hr old    35 larva L3 puffstage 1-2    158 larva L3 puffstage 3-6    82 larva L3 puffstage 7-9    19 white prepupae new    16 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    6 adult male 01day    6 adult male 05day    26 adult male 30day    10 adult female 01day    4 adult female 05day    6 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    28 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    39 wing disc CME-W2    9 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    444 wing disc ML-DmD21    82 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4  (28) embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1  (39) wing disc CME-W2    9 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3  (444) wing disc ML-DmD21  (82) wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    28 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    39 wing disc CME-W2    9 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3  (444) wing disc ML-DmD21    82 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    28 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    39 wing disc CME-W2    9 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    444 wing disc ML-DmD21    82 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    28 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    39 wing disc CME-W2    9 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    444 wing disc ML-DmD21    82 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4  28 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1  (39) wing disc CME-W2    9 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3  (444) wing disc ML-DmD21  (82) wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    28 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    39 wing disc CME-W2    9 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3  (444) wing disc ML-DmD21    82 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    28 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    39 wing disc CME-W2    9 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    444 wing disc ML-DmD21    82 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    217 Cadmium 50 mM 12 hrs, larvae L3    53 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    157 Ethanol 10% 3 hrs, larvae L3    69 Caffeine 1.5 mg/ml 4 hrs, larvae L3    89 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    183 Rotenone 8 μg 12 hrs, larvae L3    236 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult  (35) Cadmium 50 mM 6 hrs, larvae L3  (217) Cadmium 50 mM 12 hrs, larvae L3  (53) Cadmium 50 mM 48 hrs, 4-day adult  (97) Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3  (157) Ethanol 10% 3 hrs, larvae L3  (69) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (89) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3  (183) Rotenone 8 μg 12 hrs, larvae L3  (236) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3  (217) Cadmium 50 mM 12 hrs, larvae L3    53 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3  (157) Ethanol 10% 3 hrs, larvae L3    69 Caffeine 1.5 mg/ml 4 hrs, larvae L3    89 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3  (183) Rotenone 8 μg 12 hrs, larvae L3  (236) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    217 Cadmium 50 mM 12 hrs, larvae L3    53 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    157 Ethanol 10% 3 hrs, larvae L3    69 Caffeine 1.5 mg/ml 4 hrs, larvae L3    89 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    183 Rotenone 8 μg 12 hrs, larvae L3    236 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    217 Cadmium 50 mM 12 hrs, larvae L3    53 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    157 Ethanol 10% 3 hrs, larvae L3    69 Caffeine 1.5 mg/ml 4 hrs, larvae L3    89 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    183 Rotenone 8 μg 12 hrs, larvae L3    236 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult  (35) Cadmium 50 mM 6 hrs, larvae L3  (217) Cadmium 50 mM 12 hrs, larvae L3  (53) Cadmium 50 mM 48 hrs, 4-day adult  (97) Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3  (157) Ethanol 10% 3 hrs, larvae L3  (69) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (89) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3  (183) Rotenone 8 μg 12 hrs, larvae L3  (236) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3  (217) Cadmium 50 mM 12 hrs, larvae L3    53 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3  (157) Ethanol 10% 3 hrs, larvae L3    69 Caffeine 1.5 mg/ml 4 hrs, larvae L3    89 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3  (183) Rotenone 8 μg 12 hrs, larvae L3  (236) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    217 Cadmium 50 mM 12 hrs, larvae L3    53 Cadmium 50 mM 48 hrs, 4-day adult    97 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    157 Ethanol 10% 3 hrs, larvae L3    69 Caffeine 1.5 mg/ml 4 hrs, larvae L3    89 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    183 Rotenone 8 μg 12 hrs, larvae L3    236 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • GH07976 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033367 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8193-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for proPO45 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 proPO45GD13836 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of proPO45 Class Mutagen Stocks Known lesion proPO45MB05593 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of proPO45 Class Mutagen Stocks Known lesion proPO45GD13836 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes proPO45GD16864 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes proPO45KK112850 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes proPO45NIG.8193R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes proPO45Scer\UAS.cNa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{proPO45-lacZ.F} No P{proPO45-lacZ.GATAmut} No P{proPO45-lacZ.RUNXmut} No
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}proPO45MB05593 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
dopamine monooxygenase activity inferred from direct assay (Li et al., 2012) L-DOPA monooxygenase activity inferred from direct assay (Li et al., 2012)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004) extracellular space inferred from direct assay (Asano and Takebuchi, 2009)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
dopamine metabolic process inferred by curator from GO:0036264 (Li et al., 2012) metabolic process inferred from electronic annotation with InterPro:IPR002227 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
proPO45 - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) proPO45 - CG34205 experimental knowledge based (Guruharsha et al., 2011) proPO45 - CG4390 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) proPO45 - CG9466 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) proPO45 - Dbp73D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) proPO45 - Fer2LCH experimental knowledge based (Guruharsha et al., 2011) proPO45 - Rfabg experimental knowledge based (Guruharsha et al., 2011) proPO45 - Su(fu) anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) proPO45 - mRpL43 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) proPO45 - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) proPO45 - nonA-l anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) proPO45 - p24-1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) proPO45 - proPO59 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) proPO45 - yellow-f experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions proPO45 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61748 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033367 DroID - A comprehensive database of gene and protein interactions. • FBgn0033367 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35910
Orthologs
OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FN535 Dipteran inclusive ortholog search EOG61ZFK0 Insect inclusive ortholog search EOG6M0CWQ Arthropod inclusive ortholog search EOG6DFN3J Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6FN535)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\proPO45     Drosophila simulans   Dsim\GD10111 Y   Drosophila sechellia   Dsec\GM20638 Y   Drosophila erecta   Dere\GG10592 Y   Drosophila yakuba   Dyak\GE22642 Y   Drosophila ananassae   Dana\GF12716 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20885 Y   Drosophila persimilis   Dper\GL16858 Y   Drosophila willistoni   Dwil\GK17810 Y   Drosophila virilis   Dvir\GJ21181     Drosophila mojavensis   Dmoj\GI19427 Y   Drosophila grimshawi   Dgri\GH20258 Y
Orthologs in non-Drosophila Dipterans (EOG61ZFK0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014544   Anopheles gambiae Malaria mosquito  Agam\PPO1   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007275
Orthologs in non-Dipteran Insects (EOG6M0CWQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\PPO Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014407 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014408 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005509 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14265 Y Atta cephalotes Leafcutter ant  Acep\ACEP18806 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13023 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17968 Y Linepithema humile Argentine ant  Lhum\LH14237 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB19558 Y Solenopsis invicta Red fire ant  Sinv\SINV17713 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004484 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI072244 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012764 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012763 Y Pediculus humanus Human body louse  Phum\PHUM448900 Y Tribolium castaneum Red flour beetle  Tcas\TC000325 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15848 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15849 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_14907 Y
Orthologs in non-Insect Arthropods (EOG6DFN3J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_326755 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10111 Drosophila sechellia Dsec\GM20638 Drosophila erecta Dere\GG10592 Drosophila yakuba Dyak\GE22642 Drosophila ananassae Dana\GF12716 Drosophila pseudoobscura pseudoobscura Dpse\GA20885 Drosophila persimilis Dper\GL16858 Drosophila willistoni Dwil\GK17810 Drosophila mojavensis Dmoj\GI19427 Drosophila grimshawi Dgri\GH20258
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	25223 w1118; Mi{ET1}proPO45MB05593
VDRC	v107772 P{KK112850}VIE-260B v50284 w1118; P{GD16864}v50284 v26941 w1118; P{GD13836}v26941/CyO
Genomic Clones ( 1 )
	BACR08E17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 50 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH07976 SD09866
Other clones	DPiM_GH07976
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH19084 LD41176 LD41178 LP06009 LP23464 RE22807 RE35161 RE41761 RE44751 RE50229 RE65991 RE68658 RE69092 RE75025 RH23581 RH26754 RH34385 RH42308 RH46975 RH50475 RH51645 RH51678 RH68660 RH68763 RH69630
Other clones	149138 214373.47 214441.40 CK01.17B.D10 CK01.17B.E4 CK01.122C.D12 EC13267 EK016747 EK093448 EK176532 EK241307 EK254719 EK298756 EP01050 EP17335 RP004067088 RP004182498 RP004214073 RP004228140 RP004253692 RP004265462 RP004467604
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033367 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35910
Antibody Information
	polyclonal (Asano and Takebuchi, 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: proPO45 CG8193 (Ferjoux et al., 2007)
Source for database merge of
Additional comments	Developmental expression profile and immunoblot analyses indicate that CG2952 does not encode the A3 phenol oxidase component originally described in FBrf0017315 and it is more likely that CG8193 encodes the A3 component of phenol oxidase. There is a discrepancy between the location of CG8193 and that of the mutant Dox-3 strains described in FBrf0043263. Thus it is possible that these mutant strains do not affect the structural locus for the A3 phenol oxidase component originally described in FBrf0017315, but instead represent a modifying factor. (Asano and Takebuchi, 2009) FlyBase curator comment: The "Dox-3, Dopa oxidase-3" locus originally described in FBrf0043263 had incorrectly been merged with the gene corresponding to the CG2952 annotation in FlyBase, based on the GenBank accession AB055857. The merged gene was called "Dox-A3, Diphenol oxidase A3" (FBgn0000487) in FlyBase, since it had been proposed (in FBrf0043263) that the Dox-3 locus was the structural locus for the A3 phenol oxidase component originally described in FBrf0017315. However, as pointed out in FBrf0207791, the AB055857 accession is chimeric, containing portions of CG2952 and CG8193 (both of are predicted to encode prophenol oxidases based on their sequence) and also of CG14196. Evidence in FBrf0207791 (developmental expression profile, immunoblot analyses) indicates that CG2952 does not encode the A3 phenol oxidase component originally described in FBrf0017315 and it is more likely that CG8193 encodes the A3 component. However FBrf0207791 notes there is a discrepancy between the location of CG8193 and that of the mutant Dox-3 strains described in FBrf0043263. Thus it is possible that these mutant strains do not affect the structural locus for the A3 phenol oxidase component originally described in FBrf0017315, but instead represent a modifying factor. Due to the uncertainty over the various components, the "Dox-A3" (FBgn0000487) gene has been split into two separate genes in FlyBase (release FB_2009_09): a gene representing the CG2952 annotation (this annotation and the gene symbol have been renamed to CG42640 in release 5.22 of the genome annotation to avoid confusion) and "Dox-3, Dopa oxidase-3", representing the locus originally described in FBrf0043263. The CG8193 gene record (FBgn0033367) remains as a separate gene record in FlyBase until more evidence is available to determine whether or not it encodes the structural locus for the A3 phenol oxidase and whether or not the Dox-3 strains affect this locus. (Millburn, 2009.9.4)
Other Comments
	FlyBase curator comment: The AB055857 accession is chimeric, containing portions of CG2952 and CG8193 (both of are predicted to encode prophenol oxidases based on their sequence) and also of CG14196. (Asada, 2001.2.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136599 RefSeq (Proteins) • NP_610443 DDBJ / EMBL / GenBank • AAF59001 AAL28200 AB055857 AI108746 AW940287 AY060652 Entrez Gene - A searchable database of RefSeq genes. • 35910 UniProtKB/Swiss-Prot • Q9V521
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Hemocyanin/hexamerin middle domain (IPR000896) Tyrosinase (IPR002227) Hemocyanin, C-terminal (IPR005203) Hemocyanin, N-terminal (IPR005204) Uncharacterised domain, di-copper centre (IPR008922) Hemocyanin/hexamerin (IPR013788) Immunoglobulin E-set (IPR014756) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH07976
Linkouts
	BioGRID - A database of protein and genetic interactions • 61748 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033367 DroID - A comprehensive database of gene and protein interactions. • FBgn0033367 DRSC - Results from RNAi screens. • FBgn0033367 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033367 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8193-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033367 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35910 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35910 modMine - Data generated by the modENCODE project. • FBgn0033367
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG8193 (Ye et al., 2009, Waterhouse et al., 2007, Altenhein et al., 2006, Christophides et al., 2002, Ferjoux et al., 2007, Keleman et al., 2009.8.5, Giot et al., 2003, Scherfer et al., 2004, Karlsson et al., 2004, Asano and Takebuchi, 2009, Riedl et al., 2005, Longworth et al., 2012, Puri et al., 2008, Ejsmont et al., 2009, Cammarato et al., 2011, Reumer et al., 2009, O'Keefe et al., 2011, Waltzer et al., 2003, Millburn, 2009.9.4, Osman et al., 2009, Nam et al., 2008, Tomancak et al., 2007, Wertheim et al., 2005, Japanese National Institute of Genetics, 2012.5.21, Li et al., 2012) DmePPO2 (Burmester, 2001) PO45 (Osman et al., 2009, Bras et al., 2012) PPO2 (Nam et al., 2008, Li et al., 2012, Chen et al., 2012) proPO45 (Ferjoux et al., 2007, ) ProPO45 (Reumer et al., 2009)
Name Synonym	prophenoloxidase 45
Secondary FlyBase IDs
References ( 41 )
Generate a list of	All references relating to this gene ( 41 )
List References by type	Research paper  ( 25 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 5 )
	Bras et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(13): 4986--4991 Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis. [FBrf0217882] Chen et al., 2012, Dev. Comp. Immunol. 38(1): 88--97 Specific amino acids affecting Drosophila melanogaster prophenoloxidase activity in vitro. [FBrf0219007] Li et al., 2012, Dev. Comp. Immunol. 36(4): 648--656 Properties of Drosophila melanogaster prophenoloxidases expressed in Escherichia coli. [FBrf0217383] Longworth et al., 2012, PLoS Genet. 8(4): e1002618 A Shared Role for RBF1 and dCAP-D3 in the Regulation of Transcription with Consequences for Innate Immunity. [FBrf0218058] O'Keefe et al., 2011, Hum. Mol. Genet. 20(3): 497--509 Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. [FBrf0212691] Show all research papers ...