Gene Dmel\Hydr1

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General Information

Symbol

Dmel\Hydr1

Species

D. melanogaster

Name

α/β hydrolase 1

Annotation symbol

CG8058

Feature type

protein_coding_gene

FlyBase ID

FBgn0033382

Gene Model Status

Current

Stock availability

4 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

45A11-45A11

Sequence location

2R:5,019,985..5,022,958 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene α/β hydrolase 1 is referred to in FlyBase by the symbol Dmel\Hydr1 (CG8058, FBgn0033382). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: lipase activity. Based on sequence similarity, it is predicted to be involved in the biological process: lipid metabolic process. 4 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: AB-hydrolase YheT, putative; Uncharacterised protein family UPF0017, hydrolase-like, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, adult Malpighian tubules, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1630623_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Hydr1. Gene sequence location is 2R:5019985..5022958.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

45A11-45A11

Limits computationally determined from genome sequence between P{lacW}l(2)45Ai^k00116&P{PZ}Su(var)2-10⁰³⁶⁹⁷ and P{lacW}CG8788^k04512&P{lacW}l(2)k13412^k13412

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Hydr1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Hydr1-RA

FBtr0088580

NM_136615

2195

525

Hydr1-RB

FBtr0300180

NM_165653

2072

438

Hydr1-RC

FBtr0302496

NM_001201963

2373

525

Hydr1-RD

FBtr0339360

2351

438

Hydr1-RE

FBtr0339361

1874

438

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Hydr1-PA

FBpp0087661

58.8

525

8.82

NP_610459

AAF58980

Hydr1-PB

FBpp0289417

49.2

438

8.35

NP_724757

AAM68811

Hydr1-PC

FBpp0291658

58.8

525

8.82

NP_001188892

ADV37141

Hydr1-PD

FBpp0308453

49.2

438

8.35

Hydr1-PE

FBpp0308454

49.2

438

8.35

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Uncharacterised protein family UPF0017, hydrolase-like, conserved site (IPR000952)

AB-hydrolase YheT, putative (IPR012020)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, adult Malpighian tubules, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland, adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		102.15
Larval Midgut		414.3
Larval Hindgut		107.3
Larval Malpighian Tubules		363.2
Larval Fat Body		87.9
Larval Salivary Gland		38.3
Larval Trachea		72.9
Larval Carcass		45.5
Adult Head		437.3
Adult Eye		332.7
Adult Brain		491.4
Adult Thoracic-Abdominal Ganglion		649.6
Adult Crop		119.9
Adult Midgut		433.6
Adult Hindgut		169.5
Adult Malpighian Tubules		1271.6
Adult Fat Body		385.4
Adult Salivary Gland		113.9
Adult Heart		251.15
Adult VirginFemale Spermatheca		295.9
Adult InseminatedFemale Spermatheca		400.7
Adult Ovary		174.3
Adult Testis		782.9
Adult Male Accessory Gland		226.6
Adult Carcass		408
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		102.15
Larval Midgut		414.3
Larval Hindgut		107.3
Larval Malpighian Tubules		363.2
Larval Fat Body		87.9
Larval Salivary Gland		38.3
Larval Trachea		72.9
Larval Carcass		45.5
Adult Head		437.3
Adult Eye		332.7
Adult Brain		491.4
Adult Thoracic-Abdominal Ganglion		(649.6)
Adult Crop		119.9
Adult Midgut		433.6
Adult Hindgut		169.5
Adult Malpighian Tubules		(1271.6)
Adult Fat Body		385.4
Adult Salivary Gland		113.9
Adult Heart		251.15
Adult VirginFemale Spermatheca		295.9
Adult InseminatedFemale Spermatheca		400.7
Adult Ovary		174.3
Adult Testis		(782.9)
Adult Male Accessory Gland		226.6
Adult Carcass		408
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		102.15
Larval Midgut		414.3
Larval Hindgut		107.3
Larval Malpighian Tubules		363.2
Larval Fat Body		87.9
Larval Salivary Gland		38.3
Larval Trachea		72.9
Larval Carcass		45.5
Adult Head		437.3
Adult Eye		332.7
Adult Brain		491.4
Adult Thoracic-Abdominal Ganglion		649.6
Adult Crop		119.9
Adult Midgut		433.6
Adult Hindgut		169.5
Adult Malpighian Tubules		(1271.6)
Adult Fat Body		385.4
Adult Salivary Gland		113.9
Adult Heart		251.15
Adult VirginFemale Spermatheca		295.9
Adult InseminatedFemale Spermatheca		400.7
Adult Ovary		174.3
Adult Testis		782.9
Adult Male Accessory Gland		226.6
Adult Carcass		408
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		102.15
Larval Midgut		414.3
Larval Hindgut		107.3
Larval Malpighian Tubules		363.2
Larval Fat Body		87.9
Larval Salivary Gland		38.3
Larval Trachea		72.9
Larval Carcass		45.5
Adult Head		437.3
Adult Eye		332.7
Adult Brain		491.4
Adult Thoracic-Abdominal Ganglion		649.6
Adult Crop		119.9
Adult Midgut		433.6
Adult Hindgut		169.5
Adult Malpighian Tubules		1271.6
Adult Fat Body		385.4
Adult Salivary Gland		113.9
Adult Heart		251.15
Adult VirginFemale Spermatheca		295.9
Adult InseminatedFemale Spermatheca		400.7
Adult Ovary		174.3
Adult Testis		782.9
Adult Male Accessory Gland		226.6
Adult Carcass		408
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		102.15
Larval Midgut		414.3
Larval Hindgut		107.3
Larval Malpighian Tubules		363.2
Larval Fat Body		87.9
Larval Salivary Gland		38.3
Larval Trachea		72.9
Larval Carcass		45.5
Adult Head		437.3
Adult Eye		332.7
Adult Brain		491.4
Adult Thoracic-Abdominal Ganglion		649.6
Adult Crop		119.9
Adult Midgut		433.6
Adult Hindgut		169.5
Adult Malpighian Tubules		1271.6
Adult Fat Body		385.4
Adult Salivary Gland		113.9
Adult Heart		251.15
Adult VirginFemale Spermatheca		295.9
Adult InseminatedFemale Spermatheca		400.7
Adult Ovary		174.3
Adult Testis		782.9
Adult Male Accessory Gland		226.6
Adult Carcass		408
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		102.15
Larval Midgut		414.3
Larval Hindgut		107.3
Larval Malpighian Tubules		363.2
Larval Fat Body		87.9
Larval Salivary Gland		38.3
Larval Trachea		72.9
Larval Carcass		45.5
Adult Head		437.3
Adult Eye		332.7
Adult Brain		491.4
Adult Thoracic-Abdominal Ganglion		649.6
Adult Crop		119.9
Adult Midgut		433.6
Adult Hindgut		169.5
Adult Malpighian Tubules		(1271.6)
Adult Fat Body		385.4
Adult Salivary Gland		113.9
Adult Heart		251.15
Adult VirginFemale Spermatheca		295.9
Adult InseminatedFemale Spermatheca		400.7
Adult Ovary		174.3
Adult Testis		782.9
Adult Male Accessory Gland		226.6
Adult Carcass		408
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		102.15
Larval Midgut		414.3
Larval Hindgut		107.3
Larval Malpighian Tubules		363.2
Larval Fat Body		87.9
Larval Salivary Gland		38.3
Larval Trachea		72.9
Larval Carcass		45.5
Adult Head		437.3
Adult Eye		332.7
Adult Brain		491.4
Adult Thoracic-Abdominal Ganglion		649.6
Adult Crop		119.9
Adult Midgut		433.6
Adult Hindgut		169.5
Adult Malpighian Tubules		1271.6
Adult Fat Body		385.4
Adult Salivary Gland		113.9
Adult Heart		251.15
Adult VirginFemale Spermatheca		295.9
Adult InseminatedFemale Spermatheca		400.7
Adult Ovary		174.3
Adult Testis		782.9
Adult Male Accessory Gland		226.6
Adult Carcass		408
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		102.15
Larval Midgut		414.3
Larval Hindgut		107.3
Larval Malpighian Tubules		363.2
Larval Fat Body		87.9
Larval Salivary Gland		38.3
Larval Trachea		72.9
Larval Carcass		45.5
Adult Head		437.3
Adult Eye		332.7
Adult Brain		491.4
Adult Thoracic-Abdominal Ganglion		649.6
Adult Crop		119.9
Adult Midgut		433.6
Adult Hindgut		169.5
Adult Malpighian Tubules		1271.6
Adult Fat Body		385.4
Adult Salivary Gland		113.9
Adult Heart		251.15
Adult VirginFemale Spermatheca		295.9
Adult InseminatedFemale Spermatheca		400.7
Adult Ovary		174.3
Adult Testis		782.9
Adult Male Accessory Gland		226.6
Adult Carcass		408
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	437.3
NA	Eye	332.7
NA	Brain	491.4
102.15	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	649.6
NA	Crop	119.9
414.3	Midgut	433.6
107.3	Hindgut	169.5
363.2	Malpighian Tubules	1271.6
87.9	Fat Body	385.4
38.3	Salivary Gland	113.9
NA	Heart	251.15
72.9	Trachea	NA
NA	VirginFemale Spermatheca	295.9
NA	InseminatedFemale Spermatheca	400.7
NA	Ovary	174.3
NA	Testis	782.9
NA	Male Accessory Gland	226.6
45.5	Carcass	408

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		4
central nervous system, pupae P8		2
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		20
head, mated 1-day female		11
head, mated 4-day female		13
head, mated 20-day female		15
head, mated 1-day male		18
head, mated 4-day male		17
head, mated 20-day male		21
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		8
digestive system, 1-day adult		17
digestive system, 4-day adult		14
digestive system, 20-day adult		19
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		8
carcass, larvae L3 wandering		3
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		13
ovary, virgin 4-day female		20
ovary, mated 4-day female		19
testis, mated 4-day male		64
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		4
central nervous system, pupae P8		2
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		20
head, mated 1-day female		11
head, mated 4-day female		13
head, mated 20-day female		15
head, mated 1-day male		18
head, mated 4-day male		17
head, mated 20-day male		21
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		8
digestive system, 1-day adult		17
digestive system, 4-day adult		14
digestive system, 20-day adult		19
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		8
carcass, larvae L3 wandering		3
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		13
ovary, virgin 4-day female		20
ovary, mated 4-day female		19
testis, mated 4-day male		(64)
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		4
central nervous system, pupae P8		2
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		20
head, mated 1-day female		11
head, mated 4-day female		13
head, mated 20-day female		15
head, mated 1-day male		18
head, mated 4-day male		17
head, mated 20-day male		21
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		8
digestive system, 1-day adult		17
digestive system, 4-day adult		14
digestive system, 20-day adult		19
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		8
carcass, larvae L3 wandering		3
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		13
ovary, virgin 4-day female		20
ovary, mated 4-day female		19
testis, mated 4-day male		64
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		4
central nervous system, pupae P8		2
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		20
head, mated 1-day female		11
head, mated 4-day female		13
head, mated 20-day female		15
head, mated 1-day male		18
head, mated 4-day male		17
head, mated 20-day male		21
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		8
digestive system, 1-day adult		17
digestive system, 4-day adult		14
digestive system, 20-day adult		19
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		8
carcass, larvae L3 wandering		3
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		13
ovary, virgin 4-day female		20
ovary, mated 4-day female		19
testis, mated 4-day male		64
accessory gland, mated 4-day male		8
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		4
central nervous system, pupae P8		2
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		20
head, mated 1-day female		11
head, mated 4-day female		13
head, mated 20-day female		15
head, mated 1-day male		18
head, mated 4-day male		17
head, mated 20-day male		21
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		8
digestive system, 1-day adult		17
digestive system, 4-day adult		14
digestive system, 20-day adult		19
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		8
carcass, larvae L3 wandering		3
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		13
ovary, virgin 4-day female		20
ovary, mated 4-day female		19
testis, mated 4-day male		64
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		4
central nervous system, pupae P8		2
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		20
head, mated 1-day female		11
head, mated 4-day female		13
head, mated 20-day female		15
head, mated 1-day male		18
head, mated 4-day male		17
head, mated 20-day male		21
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		8
digestive system, 1-day adult		17
digestive system, 4-day adult		14
digestive system, 20-day adult		19
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		8
carcass, larvae L3 wandering		3
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		13
ovary, virgin 4-day female		20
ovary, mated 4-day female		19
testis, mated 4-day male		(64)
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		4
central nervous system, pupae P8		2
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		20
head, mated 1-day female		11
head, mated 4-day female		13
head, mated 20-day female		15
head, mated 1-day male		18
head, mated 4-day male		17
head, mated 20-day male		21
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		8
digestive system, 1-day adult		17
digestive system, 4-day adult		14
digestive system, 20-day adult		19
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		8
carcass, larvae L3 wandering		3
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		13
ovary, virgin 4-day female		20
ovary, mated 4-day female		19
testis, mated 4-day male		64
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		20
central nervous system, larvae L3		4
central nervous system, pupae P8		2
head, virgin 1-day female		12
head, virgin 4-day female		14
head, virgin 20-day female		20
head, mated 1-day female		11
head, mated 4-day female		13
head, mated 20-day female		15
head, mated 1-day male		18
head, mated 4-day male		17
head, mated 20-day male		21
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		8
digestive system, 1-day adult		17
digestive system, 4-day adult		14
digestive system, 20-day adult		19
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		8
carcass, larvae L3 wandering		3
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		13
ovary, virgin 4-day female		20
ovary, mated 4-day female		19
testis, mated 4-day male		64
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed in adult male stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		33
embryo 02-04hr		27
embryo 04-06hr		31
embryo 06-08hr		28
embryo 08-10hr		20
embryo 10-12hr		11
embryo 12-14hr		8
embryo 14-16hr		9
embryo 16-18hr		8
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		11
larva L2		12
larva L3 12hr old		7
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		11
white prepupae new		9
white prepupae 12hr		13
white prepupae 24hr		16
pupae 2d postWPP		18
pupae 3d postWPP		20
pupae 4d postWPP		30
adult male 01day		55
adult male 05day		75
adult male 30day		68
adult female 01day		26
adult female 05day		24
adult female 30day		26
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(33)
embryo 02-04hr		(27)
embryo 04-06hr		(31)
embryo 06-08hr		(28)
embryo 08-10hr		20
embryo 10-12hr		11
embryo 12-14hr		8
embryo 14-16hr		9
embryo 16-18hr		8
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		11
larva L2		12
larva L3 12hr old		7
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		11
white prepupae new		9
white prepupae 12hr		13
white prepupae 24hr		16
pupae 2d postWPP		18
pupae 3d postWPP		20
pupae 4d postWPP		(30)
adult male 01day		(55)
adult male 05day		(75)
adult male 30day		(68)
adult female 01day		26
adult female 05day		24
adult female 30day		26
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		33
embryo 02-04hr		27
embryo 04-06hr		31
embryo 06-08hr		28
embryo 08-10hr		20
embryo 10-12hr		11
embryo 12-14hr		8
embryo 14-16hr		9
embryo 16-18hr		8
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		11
larva L2		12
larva L3 12hr old		7
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		11
white prepupae new		9
white prepupae 12hr		13
white prepupae 24hr		16
pupae 2d postWPP		18
pupae 3d postWPP		20
pupae 4d postWPP		30
adult male 01day		55
adult male 05day		75
adult male 30day		68
adult female 01day		26
adult female 05day		24
adult female 30day		26
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		33
embryo 02-04hr		27
embryo 04-06hr		31
embryo 06-08hr		28
embryo 08-10hr		20
embryo 10-12hr		11
embryo 12-14hr		8
embryo 14-16hr		9
embryo 16-18hr		8
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		11
larva L2		12
larva L3 12hr old		7
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		11
white prepupae new		9
white prepupae 12hr		13
white prepupae 24hr		16
pupae 2d postWPP		18
pupae 3d postWPP		20
pupae 4d postWPP		30
adult male 01day		55
adult male 05day		75
adult male 30day		68
adult female 01day		26
adult female 05day		24
adult female 30day		26
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		33
embryo 02-04hr		27
embryo 04-06hr		31
embryo 06-08hr		28
embryo 08-10hr		20
embryo 10-12hr		11
embryo 12-14hr		8
embryo 14-16hr		9
embryo 16-18hr		8
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		11
larva L2		12
larva L3 12hr old		7
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		11
white prepupae new		9
white prepupae 12hr		13
white prepupae 24hr		16
pupae 2d postWPP		18
pupae 3d postWPP		20
pupae 4d postWPP		30
adult male 01day		55
adult male 05day		75
adult male 30day		68
adult female 01day		26
adult female 05day		24
adult female 30day		26
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(33)
embryo 02-04hr		27
embryo 04-06hr		31
embryo 06-08hr		28
embryo 08-10hr		20
embryo 10-12hr		11
embryo 12-14hr		8
embryo 14-16hr		9
embryo 16-18hr		8
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		11
larva L2		12
larva L3 12hr old		7
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		11
white prepupae new		9
white prepupae 12hr		13
white prepupae 24hr		16
pupae 2d postWPP		18
pupae 3d postWPP		20
pupae 4d postWPP		30
adult male 01day		(55)
adult male 05day		(75)
adult male 30day		(68)
adult female 01day		26
adult female 05day		24
adult female 30day		26
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		33
embryo 02-04hr		27
embryo 04-06hr		31
embryo 06-08hr		28
embryo 08-10hr		20
embryo 10-12hr		11
embryo 12-14hr		8
embryo 14-16hr		9
embryo 16-18hr		8
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		11
larva L2		12
larva L3 12hr old		7
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		11
white prepupae new		9
white prepupae 12hr		13
white prepupae 24hr		16
pupae 2d postWPP		18
pupae 3d postWPP		20
pupae 4d postWPP		30
adult male 01day		55
adult male 05day		75
adult male 30day		68
adult female 01day		26
adult female 05day		24
adult female 30day		26
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		33
embryo 02-04hr		27
embryo 04-06hr		31
embryo 06-08hr		28
embryo 08-10hr		20
embryo 10-12hr		11
embryo 12-14hr		8
embryo 14-16hr		9
embryo 16-18hr		8
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		11
larva L2		12
larva L3 12hr old		7
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		11
white prepupae new		9
white prepupae 12hr		13
white prepupae 24hr		16
pupae 2d postWPP		18
pupae 3d postWPP		20
pupae 4d postWPP		30
adult male 01day		55
adult male 05day		75
adult male 30day		68
adult female 01day		26
adult female 05day		24
adult female 30day		26
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		14
Schneider line 2 Sg4		10
embryonic 1182-4H		9
embryonic GM2		10
embryonic Kc167		7
embryonic S1		13
embryonic S3		10
leg disc CME L1		8
wing disc CME-W2		9
wing disc ML-DmD8		10
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		8
wing disc ML-DmD21		5
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		12
CNS ML-DmBG2-c2		25
tumorous blood cells mbn2		5
ovary fGS/OSS		15
ovary OSC		4
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		14
Schneider line 2 Sg4		10
embryonic 1182-4H		9
embryonic GM2		10
embryonic Kc167		7
embryonic S1		13
embryonic S3		10
leg disc CME L1		8
wing disc CME-W2		9
wing disc ML-DmD8		10
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		8
wing disc ML-DmD21		5
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		12
CNS ML-DmBG2-c2		25
tumorous blood cells mbn2		5
ovary fGS/OSS		15
ovary OSC		4
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		14
Schneider line 2 Sg4		10
embryonic 1182-4H		9
embryonic GM2		10
embryonic Kc167		7
embryonic S1		13
embryonic S3		10
leg disc CME L1		8
wing disc CME-W2		9
wing disc ML-DmD8		10
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		8
wing disc ML-DmD21		5
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		12
CNS ML-DmBG2-c2		25
tumorous blood cells mbn2		5
ovary fGS/OSS		15
ovary OSC		4
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		14
Schneider line 2 Sg4		10
embryonic 1182-4H		9
embryonic GM2		10
embryonic Kc167		7
embryonic S1		13
embryonic S3		10
leg disc CME L1		8
wing disc CME-W2		9
wing disc ML-DmD8		10
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		8
wing disc ML-DmD21		5
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		12
CNS ML-DmBG2-c2		25
tumorous blood cells mbn2		5
ovary fGS/OSS		15
ovary OSC		4
ovary OSS		3
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		14
Schneider line 2 Sg4		10
embryonic 1182-4H		9
embryonic GM2		10
embryonic Kc167		7
embryonic S1		13
embryonic S3		10
leg disc CME L1		8
wing disc CME-W2		9
wing disc ML-DmD8		10
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		8
wing disc ML-DmD21		5
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		12
CNS ML-DmBG2-c2		25
tumorous blood cells mbn2		5
ovary fGS/OSS		15
ovary OSC		4
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		14
Schneider line 2 Sg4		10
embryonic 1182-4H		9
embryonic GM2		10
embryonic Kc167		7
embryonic S1		13
embryonic S3		10
leg disc CME L1		8
wing disc CME-W2		9
wing disc ML-DmD8		10
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		8
wing disc ML-DmD21		5
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		12
CNS ML-DmBG2-c2		25
tumorous blood cells mbn2		5
ovary fGS/OSS		15
ovary OSC		4
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		14
Schneider line 2 Sg4		10
embryonic 1182-4H		9
embryonic GM2		10
embryonic Kc167		7
embryonic S1		13
embryonic S3		10
leg disc CME L1		8
wing disc CME-W2		9
wing disc ML-DmD8		10
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		8
wing disc ML-DmD21		5
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		12
CNS ML-DmBG2-c2		25
tumorous blood cells mbn2		5
ovary fGS/OSS		15
ovary OSC		4
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		14
Schneider line 2 Sg4		10
embryonic 1182-4H		9
embryonic GM2		10
embryonic Kc167		7
embryonic S1		13
embryonic S3		10
leg disc CME L1		8
wing disc CME-W2		9
wing disc ML-DmD8		10
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		8
wing disc ML-DmD21		5
wing disc ML-DmD32		10
haltere disc ML-DmD17-c3		11
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		12
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		12
CNS ML-DmBG2-c2		25
tumorous blood cells mbn2		5
ovary fGS/OSS		15
ovary OSC		4
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		5
heat shock, 4-day adult		17
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		13
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		30
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		15
Caffeine 25 mg/ml 48 hrs, 4-day adult		7
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		32
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		5
heat shock, 4-day adult		17
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		13
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		(30)
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		15
Caffeine 25 mg/ml 48 hrs, 4-day adult		7
Paraquat 5 mM 48 hrs, 4-day adult		(30)
Paraquat 10 mM 48 hrs, 4-day adult		(32)
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		5
heat shock, 4-day adult		17
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		13
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		30
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		15
Caffeine 25 mg/ml 48 hrs, 4-day adult		7
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		32
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		5
heat shock, 4-day adult		17
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		13
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		30
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		15
Caffeine 25 mg/ml 48 hrs, 4-day adult		7
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		32
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		5
heat shock, 4-day adult		17
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		13
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		30
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		15
Caffeine 25 mg/ml 48 hrs, 4-day adult		7
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		32
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		5
heat shock, 4-day adult		17
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		13
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		30
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		15
Caffeine 25 mg/ml 48 hrs, 4-day adult		7
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		32
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		5
heat shock, 4-day adult		17
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		13
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		30
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		15
Caffeine 25 mg/ml 48 hrs, 4-day adult		7
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		32
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		5
heat shock, 4-day adult		17
Cadmium 50 mM 6 hrs, larvae L3		7
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		13
Zinc 5 mM 12 hrs, larvae L3		6
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		30
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		5
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		15
Caffeine 25 mg/ml 48 hrs, 4-day adult		7
Paraquat 5 mM 48 hrs, 4-day adult		30
Paraquat 10 mM 48 hrs, 4-day adult		32
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0033382

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG8058-RB

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for Hydr1

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

Hydr1^GD4530

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of Hydr1	Class	Mutagen	Stocks	Known lesion
Hydr1^MB04988			1	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Hydr1	Mutagen	Stocks	Known lesion
Hydr1^GD4530	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
Hydr1^KK101066	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Hydr1^NIG.8058R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{KK101066}

P{NIG.8058R}

Insertions

Type of insertions

Name

Expression data

insertion of enhancer trap binary system

Mi{ET1}Hydr1^MB04988

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

There is no information supporting a cellular component term for this gene.

(Based on a review of available data on: 2010-03-25)

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 3 terms )

Molecular Function

CV term

Evidence

References

carboxylesterase activity

inferred from electronic annotation with InterPro:IPR000952, InterPro:IPR012020

(FlyBase Curators et al., 2004-)

lipase activity

inferred from sequence alignment with Hydr2

(Wisotzkey et al., 2003)

Biological Process

CV term

Evidence

References

lipid metabolic process

inferred from sequence alignment with Hydr2

(Wisotzkey et al., 2003)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Hydr1 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

61768

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0033382

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

35930

Orthologs

OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6Q85H9

Dipteran inclusive ortholog search

EOG6BRWV7

Insect inclusive ortholog search

EOG663Z80

Arthropod inclusive ortholog search

EOG6RV17C

Metazoa inclusive ortholog search

EOG6P8TCC

Orthologs in Drosophila Species (EOG6Q85H9)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA24851

Drosophila persimilis

Dper\GL17624

Drosophila willistoni

Dwil\GK22950

Drosophila virilis

Dvir\GJ14963

Drosophila mojavensis

Dmoj\GI19583

Drosophila grimshawi

Dgri\GH20397

Orthologs in non-Drosophila Dipterans (EOG6BRWV7)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL015298

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010695

Anopheles gambiae

Malaria mosquito

Agam\AGAP006819

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ019675

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ002340

Orthologs in non-Dipteran Insects (EOG663Z80)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB53831

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006884

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006885

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH15046

Atta cephalotes

Leafcutter ant

Acep\ACEP27163

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO20318

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL15610

Linepithema humile

Argentine ant

Lhum\LH24840

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB23074

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008343

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003741

Bombyx mori

Silkmoth

Bmor\BGIBMGA014413

Pediculus humanus

Human body louse

Phum\PHUM616990

Orthologs in non-Insect Arthropods (EOG6RV17C)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Deer tick

Isca\ISCW021363

Ixodes scapularis

Deer tick

Isca\ISCW014293

Orthologs in non-Arthropod Metazoa (EOG6P8TCC)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\Y60A3A.7

Caenorhabditis elegans

Nematode

Cele\C44C1.5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_007127gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_003148gn

Danio rerio

Zebrafish

Drer\abhd3

Xenopus tropicalis

Western clawed frog

Xtro\abhd1

Xenopus tropicalis

Western clawed frog

Xtro\abhd3

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000031457

Gallus gallus

Domestic chicken

Ggal\ABHD3

Mus musculus

House mouse

Mmus\Abhd3

Rattus norvegicus

Norway rat

Rnor\Abhd1

Rattus norvegicus

Norway rat

Rnor\Abhd3

Homo sapiens

Human

Hsap\ABHD3

Homo sapiens

Human

Hsap\ABHD1

Human Orthologs (2)

Gene

OMIM

HGNC

Hsap\ABHD3

Hsap\ABHD1

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA24851

Drosophila persimilis

Dper\GL17624

Drosophila willistoni

Dwil\GK22950

Drosophila virilis

Dvir\GJ14963

Drosophila mojavensis

Dmoj\GI19583

Drosophila grimshawi

Dgri\GH20397

Stocks & Reagents

Stocks Listed in FlyBase ( 4 )

Bloomington

24314

w¹¹¹⁸; Mi{ET1}Hydr1^MB04988

VDRC

v108286

P{KK101066}VIE-260B

v13315

w¹¹¹⁸ P{GD4530}v13315

v13314

w¹¹¹⁸; P{GD4530}v13314

Genomic Clones ( 1 )

BACR10M14

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 32 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

GM08242

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0033382

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

35930

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for identity of: Hydr1 CG8058

(Wisotzkey et al., 2003)

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

35930

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Uncharacterised protein family UPF0017, hydrolase-like, conserved site (IPR000952)

AB-hydrolase YheT, putative (IPR012020)

Linkouts

BioGRID - A database of protein and genetic interactions

•

61768

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0033382

DRSC - Results from RNAi screens.

•

FBgn0033382

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0033382

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG8058-RB

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0033382

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

35930

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

35930

modMine - Data generated by the modENCODE project.

•

FBgn0033382

Synonyms & Secondary IDs ( 4 )

Reported As

Symbol Synonym

CG8058

(Wisotzkey et al., 2003, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21)

Dm.HYDR1

(Wisotzkey et al., 2003)

Hydr1

Name Synonym

CG8058

α/β hydrolase 1

Secondary FlyBase IDs

References ( 14 )

Research paper

Blanco et al., 2010, BMC Dev. Biol. 10: 94: Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812]
Asha et al., 2003, Genetics 163(1): 203--215: Analysis of ras-induced overproliferation in Drosophila hemocytes. [FBrf0155813]
Wisotzkey et al., 2003, J. Mol. Evol. 56(3): 351--361: Alpha/beta hydrolase2, a predicated gene adjacent to Mad in Drosophila melanogaster, belongs to a new global multigene family and is associated with obesity. [FBrf0159075]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Bellen, 2007.8.28, Set756.xml: Set756.xml [FBrf0200263]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

FlyBase analysis

FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase.: Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]