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Gene Dmel\Updo

General Information
Symbol	Dmel\Updo	Species	D. melanogaster
Name	Updo	Annotation symbol	CG1818
Feature type	protein_coding_gene	FlyBase ID	FBgn0033428
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	45F5-45F5	Sequence location	2R:5,472,148..5,473,631 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Updo is referred to in FlyBase by the symbol Dmel\Updo (CG1818, FBgn0033428). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: uroporphyrinogen decarboxylase activity. It is reported to be involved in the biological process: heme biosynthetic process; porphyrin-containing compound biosynthetic process. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Uroporphyrinogen decarboxylase (URO-D); Uroporphyrinogen decarboxylase HemE. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult heart, adult fat body, larval/adult salivary gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1627448_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Updo. Gene sequence location is 2R:5472148..5473631.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 45F5-45F5   Limits computationally determined from genome sequence between P{lacW}l(2)k09501k09501 and P{PZ}Mmp202353&P{PZ}Uba105642
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Updo for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Updo-RA FBtr0088524  NM_136657   1299   356
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Updo-PA   FBpp0087607   40.0   356   6.52     NP_610501   AAF58922
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Uroporphyrinogen decarboxylase (URO-D) (IPR000257) Uroporphyrinogen decarboxylase HemE (IPR006361)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696990   AE013599 AAF58922   AI260239   AY119238 AAM51098   AY231662   BE976385   BF501891   BH256427   BI243708   BI637149   BI637407   BI637668   BI639090   BT044350   BX040360   CO155955   CO270693   CO299838   CO320696   CO326013   EC062276   EC078721   EC197840   EC220162   EC251791   EC265741   EV583066
UniProtKB/Swiss-Prot	Q9V595
UniProtKB/TrEMBL	B7YZR9 Q8MRV9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | intense & ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) Comment:rapidly degraded organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval midgut   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult heart, adult fat body, larval/adult salivary gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    314.45 Larval Midgut    243.5 Larval Hindgut    296.3 Larval Malpighian Tubules    331.1 Larval Fat Body    216 Larval Salivary Gland    516.5 Larval Trachea    344.425 Larval Carcass    345.075 Adult Head    329.2 Adult Eye    306.525 Adult Brain    324.2 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    766.1 Adult Midgut    351.1 Adult Hindgut    699.6 Adult Malpighian Tubules    291.7 Adult Fat Body    879.1 Adult Salivary Gland    893.9 Adult Heart    1025.8 Adult VirginFemale Spermatheca    472 Adult InseminatedFemale Spermatheca    458.6 Adult Ovary    439.5 Adult Testis    152.1 Adult Male Accessory Gland    463.9 Adult Carcass    780.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    314.45 Larval Midgut    243.5 Larval Hindgut    296.3 Larval Malpighian Tubules    331.1 Larval Fat Body    216 Larval Salivary Gland  516.5 Larval Trachea    344.425 Larval Carcass    345.075 Adult Head    329.2 Adult Eye    306.525 Adult Brain    324.2 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop  (766.1) Adult Midgut    351.1 Adult Hindgut  (699.6) Adult Malpighian Tubules    291.7 Adult Fat Body  (879.1) Adult Salivary Gland  (893.9) Adult Heart  (1025.8) Adult VirginFemale Spermatheca    472 Adult InseminatedFemale Spermatheca    458.6 Adult Ovary    439.5 Adult Testis    152.1 Adult Male Accessory Gland    463.9 Adult Carcass  (780.6) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    314.45 Larval Midgut    243.5 Larval Hindgut    296.3 Larval Malpighian Tubules    331.1 Larval Fat Body    216 Larval Salivary Gland    516.5 Larval Trachea    344.425 Larval Carcass    345.075 Adult Head    329.2 Adult Eye    306.525 Adult Brain    324.2 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    766.1 Adult Midgut    351.1 Adult Hindgut    699.6 Adult Malpighian Tubules    291.7 Adult Fat Body    879.1 Adult Salivary Gland    893.9 Adult Heart  1025.8 Adult VirginFemale Spermatheca    472 Adult InseminatedFemale Spermatheca    458.6 Adult Ovary    439.5 Adult Testis    152.1 Adult Male Accessory Gland    463.9 Adult Carcass    780.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    314.45 Larval Midgut    243.5 Larval Hindgut    296.3 Larval Malpighian Tubules    331.1 Larval Fat Body    216 Larval Salivary Gland    516.5 Larval Trachea    344.425 Larval Carcass    345.075 Adult Head    329.2 Adult Eye    306.525 Adult Brain    324.2 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    766.1 Adult Midgut    351.1 Adult Hindgut    699.6 Adult Malpighian Tubules    291.7 Adult Fat Body    879.1 Adult Salivary Gland    893.9 Adult Heart    1025.8 Adult VirginFemale Spermatheca    472 Adult InseminatedFemale Spermatheca    458.6 Adult Ovary    439.5 Adult Testis    152.1 Adult Male Accessory Gland    463.9 Adult Carcass    780.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    314.45 Larval Midgut    243.5 Larval Hindgut    296.3 Larval Malpighian Tubules    331.1 Larval Fat Body    216 Larval Salivary Gland    516.5 Larval Trachea    344.425 Larval Carcass    345.075 Adult Head    329.2 Adult Eye    306.525 Adult Brain    324.2 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    766.1 Adult Midgut    351.1 Adult Hindgut    699.6 Adult Malpighian Tubules    291.7 Adult Fat Body    879.1 Adult Salivary Gland    893.9 Adult Heart    1025.8 Adult VirginFemale Spermatheca    472 Adult InseminatedFemale Spermatheca    458.6 Adult Ovary    439.5 Adult Testis    152.1 Adult Male Accessory Gland    463.9 Adult Carcass    780.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    314.45 Larval Midgut    243.5 Larval Hindgut    296.3 Larval Malpighian Tubules    331.1 Larval Fat Body    216 Larval Salivary Gland  516.5 Larval Trachea    344.425 Larval Carcass    345.075 Adult Head    329.2 Adult Eye    306.525 Adult Brain    324.2 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop  766.1 Adult Midgut    351.1 Adult Hindgut  699.6 Adult Malpighian Tubules    291.7 Adult Fat Body  (879.1) Adult Salivary Gland  (893.9) Adult Heart  (1025.8) Adult VirginFemale Spermatheca    472 Adult InseminatedFemale Spermatheca    458.6 Adult Ovary    439.5 Adult Testis    152.1 Adult Male Accessory Gland    463.9 Adult Carcass  780.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    314.45 Larval Midgut    243.5 Larval Hindgut    296.3 Larval Malpighian Tubules    331.1 Larval Fat Body    216 Larval Salivary Gland    516.5 Larval Trachea    344.425 Larval Carcass    345.075 Adult Head    329.2 Adult Eye    306.525 Adult Brain    324.2 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    766.1 Adult Midgut    351.1 Adult Hindgut    699.6 Adult Malpighian Tubules    291.7 Adult Fat Body    879.1 Adult Salivary Gland    893.9 Adult Heart  1025.8 Adult VirginFemale Spermatheca    472 Adult InseminatedFemale Spermatheca    458.6 Adult Ovary    439.5 Adult Testis    152.1 Adult Male Accessory Gland    463.9 Adult Carcass    780.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    314.45 Larval Midgut    243.5 Larval Hindgut    296.3 Larval Malpighian Tubules    331.1 Larval Fat Body    216 Larval Salivary Gland    516.5 Larval Trachea    344.425 Larval Carcass    345.075 Adult Head    329.2 Adult Eye    306.525 Adult Brain    324.2 Adult Thoracic-Abdominal Ganglion    372.6 Adult Crop    766.1 Adult Midgut    351.1 Adult Hindgut    699.6 Adult Malpighian Tubules    291.7 Adult Fat Body    879.1 Adult Salivary Gland    893.9 Adult Heart    1025.8 Adult VirginFemale Spermatheca    472 Adult InseminatedFemale Spermatheca    458.6 Adult Ovary    439.5 Adult Testis    152.1 Adult Male Accessory Gland    463.9 Adult Carcass    780.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    329.2   NA  Eye    306.525   NA  Brain    324.2   314.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    372.6   NA  Crop    766.1   243.5  Midgut    351.1   296.3  Hindgut    699.6   331.1  Malpighian Tubules    291.7   216  Fat Body    879.1   516.5  Salivary Gland    893.9   NA  Heart    1025.8   344.425  Trachea    NA   NA  VirginFemale Spermatheca    472   NA  InseminatedFemale Spermatheca    458.6   NA  Ovary    439.5   NA  Testis    152.1   NA  Male Accessory Gland    463.9   345.075  Carcass    780.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    30 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    19 head, virgin 20-day female    22 head, mated 1-day female    17 head, mated 4-day female    18 head, mated 20-day female    18 head, mated 1-day male    33 head, mated 4-day male    26 head, mated 20-day male    41 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    25 digestive system, 4-day adult    18 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    41 carcass, 1-day adult    28 carcass, 4-day adult    40 carcass, 20-day adult    44 ovary, virgin 4-day female    44 ovary, mated 4-day female    42 testis, mated 4-day male    56 accessory gland, mated 4-day male    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (52) central nervous system, larvae L3  (30) central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    19 head, virgin 20-day female    22 head, mated 1-day female    17 head, mated 4-day female    18 head, mated 20-day female    18 head, mated 1-day male  (33) head, mated 4-day male  26 head, mated 20-day male  (41) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    7 digestive system, larvae L3 wandering  (30) digestive system, 1-day adult    25 digestive system, 4-day adult    18 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering  (41) carcass, 1-day adult  (28) carcass, 4-day adult  (40) carcass, 20-day adult  (44) ovary, virgin 4-day female  (44) ovary, mated 4-day female  (42) testis, mated 4-day male  (56) accessory gland, mated 4-day male  (39) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    30 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    19 head, virgin 20-day female    22 head, mated 1-day female    17 head, mated 4-day female    18 head, mated 20-day female    18 head, mated 1-day male    33 head, mated 4-day male    26 head, mated 20-day male    41 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    25 digestive system, 4-day adult    18 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    41 carcass, 1-day adult    28 carcass, 4-day adult    40 carcass, 20-day adult    44 ovary, virgin 4-day female    44 ovary, mated 4-day female    42 testis, mated 4-day male    56 accessory gland, mated 4-day male    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    30 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    19 head, virgin 20-day female    22 head, mated 1-day female    17 head, mated 4-day female    18 head, mated 20-day female    18 head, mated 1-day male    33 head, mated 4-day male    26 head, mated 20-day male    41 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    25 digestive system, 4-day adult    18 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    41 carcass, 1-day adult    28 carcass, 4-day adult    40 carcass, 20-day adult    44 ovary, virgin 4-day female    44 ovary, mated 4-day female    42 testis, mated 4-day male    56 accessory gland, mated 4-day male    39 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    30 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    19 head, virgin 20-day female    22 head, mated 1-day female    17 head, mated 4-day female    18 head, mated 20-day female    18 head, mated 1-day male    33 head, mated 4-day male    26 head, mated 20-day male    41 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    25 digestive system, 4-day adult    18 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    41 carcass, 1-day adult    28 carcass, 4-day adult    40 carcass, 20-day adult    44 ovary, virgin 4-day female    44 ovary, mated 4-day female    42 testis, mated 4-day male    56 accessory gland, mated 4-day male    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (52) central nervous system, larvae L3  30 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    19 head, virgin 20-day female    22 head, mated 1-day female    17 head, mated 4-day female    18 head, mated 20-day female    18 head, mated 1-day male  (33) head, mated 4-day male  26 head, mated 20-day male  (41) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    7 digestive system, larvae L3 wandering  30 digestive system, 1-day adult    25 digestive system, 4-day adult    18 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering  (41) carcass, 1-day adult  28 carcass, 4-day adult  (40) carcass, 20-day adult  (44) ovary, virgin 4-day female  (44) ovary, mated 4-day female  (42) testis, mated 4-day male  (56) accessory gland, mated 4-day male  (39) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    30 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    19 head, virgin 20-day female    22 head, mated 1-day female    17 head, mated 4-day female    18 head, mated 20-day female    18 head, mated 1-day male    33 head, mated 4-day male    26 head, mated 20-day male    41 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    25 digestive system, 4-day adult    18 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    41 carcass, 1-day adult    28 carcass, 4-day adult    40 carcass, 20-day adult    44 ovary, virgin 4-day female    44 ovary, mated 4-day female    42 testis, mated 4-day male    56 accessory gland, mated 4-day male    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    30 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    19 head, virgin 20-day female    22 head, mated 1-day female    17 head, mated 4-day female    18 head, mated 20-day female    18 head, mated 1-day male    33 head, mated 4-day male    26 head, mated 20-day male    41 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    25 digestive system, 4-day adult    18 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    6 carcass, larvae L3 wandering    41 carcass, 1-day adult    28 carcass, 4-day adult    40 carcass, 20-day adult    44 ovary, virgin 4-day female    44 ovary, mated 4-day female    42 testis, mated 4-day male    56 accessory gland, mated 4-day male    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    26 embryo 04-06hr    47 embryo 06-08hr    63 embryo 08-10hr    58 embryo 10-12hr    93 embryo 12-14hr    56 embryo 14-16hr    73 embryo 16-18hr    56 embryo 18-20hr    47 embryo 20-22hr    39 embryo 22-24hr    39 larva L1    71 larva L2    88 larva L3 12hr old    56 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    62 white prepupae new    74 white prepupae 12hr    47 white prepupae 24hr    55 pupae 2d postWPP    53 pupae 3d postWPP    66 pupae 4d postWPP    60 adult male 01day    58 adult male 05day    66 adult male 30day    75 adult female 01day    86 adult female 05day    73 adult female 30day    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (80) embryo 02-04hr  26 embryo 04-06hr  (47) embryo 06-08hr  (63) embryo 08-10hr  (58) embryo 10-12hr  (93) embryo 12-14hr  (56) embryo 14-16hr  (73) embryo 16-18hr  (56) embryo 18-20hr  (47) embryo 20-22hr  (39) embryo 22-24hr  (39) larva L1  (71) larva L2  (88) larva L3 12hr old  (56) larva L3 puffstage 1-2  (39) larva L3 puffstage 3-6  (48) larva L3 puffstage 7-9  (62) white prepupae new  (74) white prepupae 12hr  (47) white prepupae 24hr  (55) pupae 2d postWPP  (53) pupae 3d postWPP  (66) pupae 4d postWPP  (60) adult male 01day  (58) adult male 05day  (66) adult male 30day  (75) adult female 01day  (86) adult female 05day  (73) adult female 30day  (78) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    26 embryo 04-06hr    47 embryo 06-08hr    63 embryo 08-10hr    58 embryo 10-12hr    93 embryo 12-14hr    56 embryo 14-16hr    73 embryo 16-18hr    56 embryo 18-20hr    47 embryo 20-22hr    39 embryo 22-24hr    39 larva L1    71 larva L2    88 larva L3 12hr old    56 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    62 white prepupae new    74 white prepupae 12hr    47 white prepupae 24hr    55 pupae 2d postWPP    53 pupae 3d postWPP    66 pupae 4d postWPP    60 adult male 01day    58 adult male 05day    66 adult male 30day    75 adult female 01day    86 adult female 05day    73 adult female 30day    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    26 embryo 04-06hr    47 embryo 06-08hr    63 embryo 08-10hr    58 embryo 10-12hr    93 embryo 12-14hr    56 embryo 14-16hr    73 embryo 16-18hr    56 embryo 18-20hr    47 embryo 20-22hr    39 embryo 22-24hr    39 larva L1    71 larva L2    88 larva L3 12hr old    56 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    62 white prepupae new    74 white prepupae 12hr    47 white prepupae 24hr    55 pupae 2d postWPP    53 pupae 3d postWPP    66 pupae 4d postWPP    60 adult male 01day    58 adult male 05day    66 adult male 30day    75 adult female 01day    86 adult female 05day    73 adult female 30day    78 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    26 embryo 04-06hr    47 embryo 06-08hr    63 embryo 08-10hr    58 embryo 10-12hr    93 embryo 12-14hr    56 embryo 14-16hr    73 embryo 16-18hr    56 embryo 18-20hr    47 embryo 20-22hr    39 embryo 22-24hr    39 larva L1    71 larva L2    88 larva L3 12hr old    56 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    62 white prepupae new    74 white prepupae 12hr    47 white prepupae 24hr    55 pupae 2d postWPP    53 pupae 3d postWPP    66 pupae 4d postWPP    60 adult male 01day    58 adult male 05day    66 adult male 30day    75 adult female 01day    86 adult female 05day    73 adult female 30day    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (80) embryo 02-04hr  26 embryo 04-06hr  (47) embryo 06-08hr  (63) embryo 08-10hr  (58) embryo 10-12hr  (93) embryo 12-14hr  (56) embryo 14-16hr  (73) embryo 16-18hr  (56) embryo 18-20hr  (47) embryo 20-22hr  (39) embryo 22-24hr  (39) larva L1  (71) larva L2  (88) larva L3 12hr old  (56) larva L3 puffstage 1-2  (39) larva L3 puffstage 3-6  (48) larva L3 puffstage 7-9  (62) white prepupae new  (74) white prepupae 12hr  (47) white prepupae 24hr  (55) pupae 2d postWPP  (53) pupae 3d postWPP  (66) pupae 4d postWPP  (60) adult male 01day  (58) adult male 05day  (66) adult male 30day  (75) adult female 01day  (86) adult female 05day  (73) adult female 30day  (78) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    26 embryo 04-06hr    47 embryo 06-08hr    63 embryo 08-10hr    58 embryo 10-12hr    93 embryo 12-14hr    56 embryo 14-16hr    73 embryo 16-18hr    56 embryo 18-20hr    47 embryo 20-22hr    39 embryo 22-24hr    39 larva L1    71 larva L2    88 larva L3 12hr old    56 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    62 white prepupae new    74 white prepupae 12hr    47 white prepupae 24hr    55 pupae 2d postWPP    53 pupae 3d postWPP    66 pupae 4d postWPP    60 adult male 01day    58 adult male 05day    66 adult male 30day    75 adult female 01day    86 adult female 05day    73 adult female 30day    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    26 embryo 04-06hr    47 embryo 06-08hr    63 embryo 08-10hr    58 embryo 10-12hr    93 embryo 12-14hr    56 embryo 14-16hr    73 embryo 16-18hr    56 embryo 18-20hr    47 embryo 20-22hr    39 embryo 22-24hr    39 larva L1    71 larva L2    88 larva L3 12hr old    56 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    62 white prepupae new    74 white prepupae 12hr    47 white prepupae 24hr    55 pupae 2d postWPP    53 pupae 3d postWPP    66 pupae 4d postWPP    60 adult male 01day    58 adult male 05day    66 adult male 30day    75 adult female 01day    86 adult female 05day    73 adult female 30day    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    130 Schneider line 2 Sg4    104 embryonic 1182-4H    55 embryonic GM2    65 embryonic Kc167    66 embryonic S1    99 embryonic S3    81 leg disc CME L1    84 wing disc CME-W2    70 wing disc ML-DmD8    51 wing disc ML-DmD9    69 wing disc ML-DmD16-c3    36 wing disc ML-DmD21    123 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    120 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    100 mixed discs ML-DmD4-c1    87 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    256 tumorous blood cells mbn2    45 ovary fGS/OSS    59 ovary OSC    42 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (130) Schneider line 2 Sg4  (104) embryonic 1182-4H  (55) embryonic GM2  (65) embryonic Kc167  (66) embryonic S1  (99) embryonic S3  (81) leg disc CME L1  (84) wing disc CME-W2  (70) wing disc ML-DmD8  (51) wing disc ML-DmD9  (69) wing disc ML-DmD16-c3  (36) wing disc ML-DmD21  (123) wing disc ML-DmD32  (37) haltere disc ML-DmD17-c3  (120) eye-antennal disc ML-DmD11  (57) antennal disc ML-DmD20-c5  (100) mixed discs ML-DmD4-c1  (87) CNS ML-DmBG1-c1  (53) CNS ML-DmBG2-c2  (256) tumorous blood cells mbn2  (45) ovary fGS/OSS  (59) ovary OSC  (42) ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (130) Schneider line 2 Sg4  104 embryonic 1182-4H    55 embryonic GM2    65 embryonic Kc167    66 embryonic S1    99 embryonic S3    81 leg disc CME L1    84 wing disc CME-W2    70 wing disc ML-DmD8    51 wing disc ML-DmD9    69 wing disc ML-DmD16-c3    36 wing disc ML-DmD21  (123) wing disc ML-DmD32    37 haltere disc ML-DmD17-c3  (120) eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    100 mixed discs ML-DmD4-c1    87 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2  (256) tumorous blood cells mbn2    45 ovary fGS/OSS    59 ovary OSC    42 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    130 Schneider line 2 Sg4    104 embryonic 1182-4H    55 embryonic GM2    65 embryonic Kc167    66 embryonic S1    99 embryonic S3    81 leg disc CME L1    84 wing disc CME-W2    70 wing disc ML-DmD8    51 wing disc ML-DmD9    69 wing disc ML-DmD16-c3    36 wing disc ML-DmD21    123 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    120 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    100 mixed discs ML-DmD4-c1    87 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    256 tumorous blood cells mbn2    45 ovary fGS/OSS    59 ovary OSC    42 ovary OSS    22 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    130 Schneider line 2 Sg4    104 embryonic 1182-4H    55 embryonic GM2    65 embryonic Kc167    66 embryonic S1    99 embryonic S3    81 leg disc CME L1    84 wing disc CME-W2    70 wing disc ML-DmD8    51 wing disc ML-DmD9    69 wing disc ML-DmD16-c3    36 wing disc ML-DmD21    123 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    120 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    100 mixed discs ML-DmD4-c1    87 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    256 tumorous blood cells mbn2    45 ovary fGS/OSS    59 ovary OSC    42 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (130) Schneider line 2 Sg4  (104) embryonic 1182-4H  (55) embryonic GM2  (65) embryonic Kc167  (66) embryonic S1  (99) embryonic S3  (81) leg disc CME L1  (84) wing disc CME-W2  (70) wing disc ML-DmD8  (51) wing disc ML-DmD9  (69) wing disc ML-DmD16-c3  (36) wing disc ML-DmD21  (123) wing disc ML-DmD32  (37) haltere disc ML-DmD17-c3  (120) eye-antennal disc ML-DmD11  (57) antennal disc ML-DmD20-c5  (100) mixed discs ML-DmD4-c1  (87) CNS ML-DmBG1-c1  (53) CNS ML-DmBG2-c2  (256) tumorous blood cells mbn2  (45) ovary fGS/OSS  (59) ovary OSC  (42) ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  130 Schneider line 2 Sg4  104 embryonic 1182-4H    55 embryonic GM2    65 embryonic Kc167    66 embryonic S1    99 embryonic S3    81 leg disc CME L1    84 wing disc CME-W2    70 wing disc ML-DmD8    51 wing disc ML-DmD9    69 wing disc ML-DmD16-c3    36 wing disc ML-DmD21  123 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3  120 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    100 mixed discs ML-DmD4-c1    87 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2  (256) tumorous blood cells mbn2    45 ovary fGS/OSS    59 ovary OSC    42 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    130 Schneider line 2 Sg4    104 embryonic 1182-4H    55 embryonic GM2    65 embryonic Kc167    66 embryonic S1    99 embryonic S3    81 leg disc CME L1    84 wing disc CME-W2    70 wing disc ML-DmD8    51 wing disc ML-DmD9    69 wing disc ML-DmD16-c3    36 wing disc ML-DmD21    123 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    120 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    100 mixed discs ML-DmD4-c1    87 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    256 tumorous blood cells mbn2    45 ovary fGS/OSS    59 ovary OSC    42 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    29 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    35 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    76 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (39) cold shock, 4-day adult  (29) heat shock, 4-day adult  (34) Cadmium 50 mM 6 hrs, larvae L3  (41) Cadmium 50 mM 12 hrs, larvae L3  (35) Cadmium 50 mM 48 hrs, 4-day adult  (27) Cadmium 100 mM 48 hrs, 4-day adult  (35) Copper 0.5 mM 12 hrs, larvae L3  (31) Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3  (36) Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3  (63) Ethanol 5% 3 hrs, larvae L3  (31) Ethanol 10% 3 hrs, larvae L3  (35) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (30) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (33) Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult  (45) Paraquat 10 mM 48 hrs, 4-day adult  (76) Rotenone 2 μg 12 hrs, larvae L3  (36) Rotenone 8 μg 12 hrs, larvae L3  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    29 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    35 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    76 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    29 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    35 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    76 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    29 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    35 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    76 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (39) cold shock, 4-day adult  29 heat shock, 4-day adult  (34) Cadmium 50 mM 6 hrs, larvae L3  (41) Cadmium 50 mM 12 hrs, larvae L3  (35) Cadmium 50 mM 48 hrs, 4-day adult  27 Cadmium 100 mM 48 hrs, 4-day adult  (35) Copper 0.5 mM 12 hrs, larvae L3  31 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3  (36) Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3  (63) Ethanol 5% 3 hrs, larvae L3  31 Ethanol 10% 3 hrs, larvae L3  (35) Caffeine 1.5 mg/ml 4 hrs, larvae L3  30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (33) Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult  (45) Paraquat 10 mM 48 hrs, 4-day adult  (76) Rotenone 2 μg 12 hrs, larvae L3  (36) Rotenone 8 μg 12 hrs, larvae L3  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    29 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    35 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    76 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    29 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    35 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    35 Caffeine 1.5 mg/ml 4 hrs, larvae L3    30 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    76 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • FI07665 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033428 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1818-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Updo Class Mutagen Stocks Known lesion UpdoKG01041 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Updo Class Mutagen Stocks Known lesion UpdoKK101275 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes UpdoGD9526 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes UpdoNIG.1818R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel8049 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9526} NA P{KK101275} NA P{NIG.1818R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}UpdoKG01041 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
uroporphyrinogen decarboxylase activity inferred from sequence or structural similarity with InterPro:IPR006361 (Swiss-Prot Project Members, 2000.10.1)
Biological Process
CV term Evidence References
heme biosynthetic process non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) porphyrin-containing compound biosynthetic process inferred from electronic annotation with InterPro:IPR000257, InterPro:IPR006361 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Updo allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61817 DroID - A comprehensive database of gene and protein interactions. • FBgn0033428 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35986
Orthologs
OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG61C7G5 Dipteran inclusive ortholog search EOG6KPTKH Insect inclusive ortholog search EOG6BP07B Arthropod inclusive ortholog search EOG6573P4 Metazoa inclusive ortholog search EOG6D5FR8
Orthologs in Drosophila Species (EOG61C7G5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Updo     Drosophila simulans   Dsim\GD10665 Y   Drosophila sechellia   Dsec\GM21135 Y   Drosophila erecta   Dere\GG24087 Y   Drosophila yakuba   Dyak\Updo Y   Drosophila ananassae   Dana\GF12476 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14829 Y   Drosophila persimilis   Dper\GL17145 Y   Drosophila willistoni   Dwil\GK15945 Y   Drosophila virilis   Dvir\Updo Y   Drosophila mojavensis   Dmoj\GI18416 Y   Drosophila grimshawi   Dgri\GH22930 Y
Orthologs in non-Drosophila Dipterans (EOG6KPTKH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006693   Anopheles gambiae Malaria mosquito  Agam\AGAP011895   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010693
Orthologs in non-Dipteran Insects (EOG6BP07B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52530   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000578   Acromyrmex echinatior Panamanian leafcutter ant  Aech\hemE   Atta cephalotes Leafcutter ant  Acep\ACEP20596   Camponotus floridanus Florida carpenter ant  Cflo\hemE   Harpegnathos saltator Jerdons jumping ant  Hsal\hemE   Linepithema humile Argentine ant  Lhum\LH17991   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19652   Solenopsis invicta Red fire ant  Sinv\SINV17991   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004051   Bombyx mori Silkmoth  Bmor\BGIBMGA000937   Pediculus humanus Human body louse  Phum\PHUM523100   Tribolium castaneum Red flour beetle  Tcas\TC030590
Orthologs in non-Insect Arthropods (EOG6573P4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\hemE   Ixodes scapularis Deer tick  Isca\ISCW020804
Orthologs in non-Arthropod Metazoa (EOG6D5FR8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003073gn   Danio rerio Zebrafish  Drer\urod   Xenopus tropicalis Western clawed frog  Xtro\urod   Gallus gallus Domestic chicken  Ggal\UROD   Mus musculus House mouse  Mmus\Urod   Rattus norvegicus Norway rat  Rnor\Urod   Homo sapiens Human  Hsap\UROD
Human Orthologs (1)
Gene OMIM HGNC Hsap\UROD
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10665 Drosophila sechellia Dsec\GM21135 Drosophila erecta Dere\GG24087 Drosophila yakuba Dyak\Updo Drosophila ananassae Dana\GF12476 Drosophila pseudoobscura pseudoobscura Dpse\GA14829 Drosophila persimilis Dper\GL17145 Drosophila willistoni Dwil\GK15945 Drosophila virilis Dvir\Updo Drosophila mojavensis Dmoj\GI18416 Drosophila grimshawi Dgri\GH22930
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	13290 y1 w67c23; P{SUPor-P}UpdoKG01041/CyO
VDRC	v105642 P{KK101275}VIE-260B
Genomic Clones ( 1 )
	BACR48G21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD19419
Other clones	FI07665 yak-em_Updo
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17467 GM08859 LP03960 RE41425 SD19074 SD19727 SD21539
Other clones	7733 50712 181363 214343.50 526996 bs50a07 CK01.128D.F3 Dmel_dig_014943_0609_3358 EK099822 EK176724 EK287236 EN07110 EP03055
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033428 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35986
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Updo CG1818 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Updo CG1818 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136657 RefSeq (Proteins) • NP_610501 DDBJ / EMBL / GenBank • AAF58922 AAM51098 ACL83081 AY119238 BH256427 BI637407 Entrez Gene - A searchable database of RefSeq genes. • 35986 UniProtKB/Swiss-Prot • Q9V595 UniProtKB/TrEMBL • B7YZR9 Q8MRV9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Uroporphyrinogen decarboxylase (URO-D) (IPR000257) Uroporphyrinogen decarboxylase HemE (IPR006361) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • FI07665
Linkouts
	BioGRID - A database of protein and genetic interactions • 61817 DroID - A comprehensive database of gene and protein interactions. • FBgn0033428 DRSC - Results from RNAi screens. • FBgn0033428 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033428 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1818-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033428 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35986 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35986 modMine - Data generated by the modENCODE project. • FBgn0033428
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG1818 (Pile et al., 2003, Keleman et al., 2009.8.5) Updo (Bartolome and Charlesworth, 2006, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Updo
Secondary FlyBase IDs
References ( 19 )
Research paper	Bartolome and Charlesworth, 2006, Genetics 173(2): 779--791 Rates and patterns of chromosomal evolution in Drosophila pseudoobscura and D. miranda. [FBrf0193909] Bartolome and Charlesworth, 2006, Genetics 174(4): 2033--2044 Evolution of amino-acid sequences and codon usage on the Drosophila miranda neo-sex chromosomes. [FBrf0191994] Pile et al., 2003, J. Biol. Chem. 278(39): 37840--37848 The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: Implications for the regulation of energy metabolism. [FBrf0162185]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Protein sequence record	Swiss-Prot Project Members, 2000.10.1, UniProtKB: Q9V595 UROPORPHYRINOGEN DECARBOXYLASE (EC 4.1.1.37) (URO-D) (UPD). [FBrf0131955]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705] Zhu, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126704]