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General Information
Symbol
Dmel\Mmp2
Species
D. melanogaster
Name
Matrix metalloproteinase 2
Annotation Symbol
CG1794
Feature Type
FlyBase ID
FBgn0033438
Gene Model Status
Stock Availability
Enzyme Name (EC)
Neprilysin (3.4.24.11)
Procollagen N-endopeptidase (3.4.24.14)
Stromelysin 1 (3.4.24.17)
Meprin A (3.4.24.18)
Procollagen C-endopeptidase (3.4.24.19)
Astacin (3.4.24.21)
Stromelysin 2 (3.4.24.22)
Matrilysin (3.4.24.23)
Gelatinase A (3.4.24.24)
Gelatinase B (3.4.24.35)
Saccharolysin (3.4.24.37)
Pitrilysin (3.4.24.55)
Insulysin (3.4.24.56)
O-sialoglycoprotein endopeptidase (3.4.24.57)
Mitochondrial intermediate peptidase (3.4.24.59)
Nardilysin (3.4.24.61)
Mitochondrial processing peptidase (3.4.24.64)
Bontoxilysin (3.4.24.69)
Oligopeptidase A (3.4.24.70)
Endothelin-converting enzyme 1 (3.4.24.71)
Fibrolase (3.4.24.72)
Gene Snapshot
Matrix metalloproteinase 2 (Mmp2) encodes a proteinase that cleaves proteins in the extracellular matrix. It contributes to remodeling the body plan during metamorphosis; matrix and tissue remodeling during axon fasciculation, dendritic reshaping, wound healing, and ovulation; and down-regulating follicle stem cell proliferation. [Date last reviewed: 2019-03-14]
Also Known As

l(2)02353, dmmp2, Dm2-MMP

Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:9,611,139..9,683,858 [-]
Recombination map

2-61

RefSeq locus
NT_033778 REGION:9611139..9683858
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (34 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001303987
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR006026, InterPro:IPR021190
(assigned by InterPro )
Biological Process (26 terms)
Terms Based on Experimental Evidence (24 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001303987
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001303987
(assigned by GO_Central )
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR021190
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000810753
(assigned by GO_Central )
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the peptidase M10A family. (Q8MPP3)
Catalytic Activity (EC)
Experimental Evidence
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1' (3.4.24.11)
Cleaves the N-propeptide of collagen chain alpha-1(I) at Pro-|-Gln and of alpha-1(II) and alpha-2(I) at Ala-|-Gln (3.4.24.14)
Preferential cleavage where P1', P2' and P3' are hydrophobic residues (3.4.24.17)
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues (3.4.24.18)
Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III (3.4.24.19)
Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2' (3.4.24.21)
Similar to stromelysin 1, but action on collagen types III, IV and V is weak (3.4.24.22)
Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin (3.4.24.23)
No action on collagen types I, II, IV, V (3.4.24.23)
Cleaves gelatin chain alpha-2(I) > alpha-1(I) (3.4.24.23)
Cleavage of gelatin type I and collagen types IV, V, VII, X (3.4.24.24)
Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln (3.4.24.24)
Cleavage of gelatin types I and V and collagen types IV and V (3.4.24.35)
Cleavage of Pro-|-Phe and Ala-|-Ala bonds (3.4.24.37)
Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain (3.4.24.55)
Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon (3.4.24.55)
Degradation of insulin, glucagon and other polypeptides (3.4.24.56)
No action on proteins (3.4.24.56)
Hydrolysis of O-sialoglycoproteins (3.4.24.57)
Cleaves 31-Arg-|-Asp-32 bond in glycophorin A (3.4.24.57)
Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated (3.4.24.57)
Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion (3.4.24.59)
Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys (3.4.24.61)
Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2 (3.4.24.64)
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin (3.4.24.69)
No detected action on small molecule substrates (3.4.24.69)
Hydrolysis of oligopeptides, with broad specificity (3.4.24.70)
Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5) (3.4.24.70)
Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1 (3.4.24.71)
Hydrolysis of 14-Ala-|-Leu-15 in insulin B chain and 413-Lys-|-Leu-414 in alpha-chain of fibrinogen (3.4.24.72)
Predictions / Assertions
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1' (3.4.24.11)
Cleaves the N-propeptide of collagen chain alpha-1(I) at Pro-|-Gln and of alpha-1(II) and alpha-2(I) at Ala-|-Gln (3.4.24.14)
Preferential cleavage where P1', P2' and P3' are hydrophobic residues (3.4.24.17)
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues (3.4.24.18)
Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III (3.4.24.19)
Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2' (3.4.24.21)
Similar to stromelysin 1, but action on collagen types III, IV and V is weak (3.4.24.22)
Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin (3.4.24.23)
No action on collagen types I, II, IV, V (3.4.24.23)
Cleaves gelatin chain alpha-2(I) > alpha-1(I) (3.4.24.23)
Cleavage of gelatin type I and collagen types IV, V, VII, X (3.4.24.24)
Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln (3.4.24.24)
Cleavage of gelatin types I and V and collagen types IV and V (3.4.24.35)
Cleavage of Pro-|-Phe and Ala-|-Ala bonds (3.4.24.37)
Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain (3.4.24.55)
Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon (3.4.24.55)
Degradation of insulin, glucagon and other polypeptides (3.4.24.56)
No action on proteins (3.4.24.56)
Hydrolysis of O-sialoglycoproteins (3.4.24.57)
Cleaves 31-Arg-|-Asp-32 bond in glycophorin A (3.4.24.57)
Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated (3.4.24.57)
Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion (3.4.24.59)
Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys (3.4.24.61)
Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2 (3.4.24.64)
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin (3.4.24.69)
No detected action on small molecule substrates (3.4.24.69)
Hydrolysis of oligopeptides, with broad specificity (3.4.24.70)
Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5) (3.4.24.70)
Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1 (3.4.24.71)
Hydrolysis of 14-Ala-|-Leu-15 in insulin B chain and 413-Lys-|-Leu-414 in alpha-chain of fibrinogen (3.4.24.72)
Summaries
Pathway (FlyBase)
Negative Regulators of FGFR Signaling Pathway -
Negative regulators of Fibroblast Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on other effectors.
Negative Regulators of Wnt-TCF Signaling Pathway -
Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
Gene Group (FlyBase)
MATRIX METALLOPROTEASES -
Matrix metalloproteases (MMPs) belong to MEROPS family M10 and also to the group of peptidases known as the "metzincins", due to a conserved methionine C-terminal to the zinc ligands. They are secreted proteins that function extracellularly. They play important roles in the degradation of extracellular matrix proteins and altering signaling pathways. There are over 20 MMPs in vertebrates, but only 2 in D. melanogaster, which cleave different substrates. (Adapted from FBrf0235071 and FBrf0239469.)
Protein Function (UniProtKB)
Has metalloproteinase activity (PubMed:11967260). Required for larval tissue histolysis during metamorphosis and is involved in pupal head eversion and fusion of the wing imaginal tissue (PubMed:12530966). Required for growth of the dorsal air sac primordium and development of the dorsal air sacs (PubMed:19751719). Promotes embryonic motor axon fasciculation (PubMed:18045838). Cleaves and activates frac to promote motor axon bundling during outgrowth (PubMed:21471368). Promotes the reshaping of adult sensory neuron dendrites from a radial to lattice-like shape which occurs after eclosion by degrading the basement membrane on which the dendrites grow (PubMed:20412776). Involved in inhibition of follicle stem cell proliferation by cleaving Dlp, inhibiting its interaction with wg and preventing Dlp-mediated spreading of wg to follicle stem cells to enhance their proliferation (PubMed:25267296). Plays a role in wound healing (PubMed:22262460). Involved in fat body dissociation which occurs during metamorphosis by degrading basement membrane components, leading to destruction of cell-basement membrane junctions (PubMed:25520167). Required for posterior follicle cell degradation and ovulation (PubMed:25695427).
(UniProt, Q8MPP3)
Summary (Interactive Fly)

enzymes required for several stereotyped motor axon pathfinding decisions and essential for axon fasciculation - Mmp2 promotes dendrite reshaping through local degradation of the basement membrane - in trachea Mmp2 inhibits FGF morphogenetic function - Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Mmp2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0088501
4156
758
FBtr0334807
3412
606
FBtr0334808
3684
650
Additional Transcript Data and Comments
Reported size (kB)

3.4 (sequence analysis)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0087585
89.1
758
8.81
FBpp0306848
72.1
606
8.74
FBpp0306849
77.3
650
9.25
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

758 (aa); 89 (kD predicted)

Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mmp2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Mmp2 is widely expressed in the embryonic CNS. At stage 15, it is expressed in the midline glia and in approximately three other glial cells per hemisegment (as identified by repo expression, situated at the base of the motor nerve roots. These may correspond to the exit glia. Mmp2 is also expressed in a subset of neurons in the embyronic CNS including the tup-expressing neurons.

Mmp2 is expressed in many tissues from stage 10 including the mesoderm, stomatogastric nervous system, ectoderm, and the peripheral nervous system. Starting in stage 14, it is expressed in segmentally repeated cells in the developing central nervous system. It is expressed in gut constrictions in stages 15 and 16 and in the embryonic brain by stage 17. In wandering third instar larvae, Mmp2 is expressed widely in the wing disc, less in leg disc, and abundantly in the morphogenetic furrow and in developing ommatidia. Expression occurs in discrete foci throughout the ventral nerve cord and brain lobes and is strong in the optic lobe.

Mmp2 transcripts are detected in embryos, larvae, pupae, and adult males and females by RT-PCR. They are not detected by northern blot. They are observed by in situ hybridization in third instar larval imaginal discs and brain. Strong expression is seen in the eye disc behind the morphogenetic furrow and in the lamina.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data

Mmp2 protein localizes to the cell membrane.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mmp2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 122 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mmp2
Transgenic constructs containing regulatory region of Mmp2
Deletions and Duplications ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (29)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
5 of 15
Yes
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
Yes
4 of 15
No
No
4 of 15
No
Yes
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (27)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
6 of 15
Yes
Yes
6 of 15
Yes
Yes
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (25)
5 of 13
Yes
Yes
3 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
No
3 of 13
No
No
3 of 13
No
No
3 of 13
No
No
3 of 13
No
No
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (29)
5 of 12
Yes
No
3 of 12
No
Yes
3 of 12
No
No
3 of 12
No
No
3 of 12
No
Yes
3 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
No
2 of 12
No
No
2 of 12
No
Yes
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (30)
6 of 15
Yes
Yes
5 of 15
No
No
5 of 15
No
Yes
4 of 15
No
No
4 of 15
No
No
4 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
5 of 15
Yes
No
4 of 15
No
Yes
4 of 15
No
Yes
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (5)
3 of 9
Yes
No
2 of 9
No
No
2 of 9
No
No
2 of 9
No
No
2 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919056E )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503US )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03MR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06ZP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03DP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (4)
4 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Negative Regulators of FGFR Signaling Pathway -
    Negative regulators of Fibroblast Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on other effectors.
    Negative Regulators of Wnt-TCF Signaling Pathway -
    Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
    Metabolic Pathways
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map

    2-61

    Cytogenetic map
    Sequence location
    2R:9,611,139..9,683,858 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    45F6-46A1
    Limits computationally determined from genome sequence between P{lacW}l(2)k09501k09501 and P{PZ}Mmp202353&P{PZ}Uba105642
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    46A1-46A2
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (26)
    Genomic Clones (43)
    cDNA Clones (47)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: Mmp2 CG1794

    Source for database merge of

    Source for merge of: l(2)02353 Mmp2

    Source for merge of: Mmp2 anon-WO0118547.84

    Additional comments

    Source for merge of Mmp2 anon-WO0118547.84 was sequence comparison ( date:051113 ).

    Other Comments

    Mmp2 limits long-distance wg signaling in the germarium. Mmp2 protein cleaves dlp protein in cultured cells and is expressed in the apical cells (and a few anterior escort cells) of the germarium niche. Mmp2 may act to limit wg signaling in the the germarium by cleaving dlp protein near the wg source, resulting in relocation of dlp protein from the cell surface to intracellular vesicles, such that dlp can no longer contact wg protein and promote long-range wg signaling.

    Putative substrate for the kinase png.

    Mutants are pupal lethal and show defects in oogenesis.

    Area matching Drosophila EST AI238523.

    Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 77 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    ApoDroso - Functional genomic database for photoreceptor development, survival and function
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (18)
    Reported As
    Symbol Synonym
    Matrix metalloproteinase 2
    Mmp2
    (Diaz-de-la-Loza et al., 2020, Jevitt et al., 2020, Zhou and Boutros, 2020, Brunet Avalos et al., 2019, Kanda et al., 2019, Kockel et al., 2019, Meltzer et al., 2019, Ramos-Lewis and Page-McCaw, 2019, Swevers, 2019, Tegeder et al., 2019, Wittes and Schüpbach, 2019, Yang and Chien, 2019, Yang et al., 2019, Ariss et al., 2018, Cho et al., 2018, Gene Disruption Project members, 2018-, Li et al., 2018, Richardson and Portela, 2018, Tsai et al., 2018, Wu et al., 2018, Cannon et al., 2017, Fochler et al., 2017, Garlapow et al., 2017, Jia et al., 2017, Kline et al., 2017, LaFever et al., 2017, Purice et al., 2017, Clandinin and Owens, 2016-, Jin et al., 2016, Pearson et al., 2016, Small and Crawford, 2016, Casas-Tintó et al., 2015, Deady and Sun, 2015, Deady et al., 2015, Duff et al., 2015, Gene Disruption Project members, 2015-, Schleede and Blair, 2015, Zhai et al., 2015, Ashwal-Fluss et al., 2014, Bonnay et al., 2014, Depetris-Chauvin et al., 2014, Jia et al., 2014, Kim and Choe, 2014, Schinaman et al., 2014, Wang and Page-McCaw, 2014, Muha and Müller, 2013, Sen et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Nfonsam et al., 2012, Stevens and Page-McCaw, 2012, Sui et al., 2012, Miller et al., 2011, Schmidt et al., 2011, Xie and Auld, 2011, Aerts et al., 2010, Wang et al., 2010, Yasunaga et al., 2010, Glasheen et al., 2009, Guha et al., 2009, Shen et al., 2009, Gilchrist et al., 2008, McClure et al., 2008, Miller et al., 2008, Dominguez-Gimenez et al., 2007, Srivastava et al., 2007, Macdonald and Long, 2006, Meyer and Aberle, 2006, Ostrin et al., 2006, Curtin et al., 2005, Lee et al., 2005)
    anon-WO0118547.84
    Name Synonyms
    Matrix Metalloprotinase 2
    Matrix metalloproteinase
    matrix metalloprotease 2
    matrix metalloproteinase
    matrix metalloproteinase 2
    matrix metalloproteinase-2
    Secondary FlyBase IDs
    • FBgn0010512
    • FBgn0061593
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (181)