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Gene Dmel\Mmp2

General Information
Symbol	Dmel\Mmp2	Species	D. melanogaster
Name	Matrix metalloproteinase 2	Annotation symbol	CG1794
Feature type	protein_coding_gene	FlyBase ID	FBgn0033438
Gene Model Status	Current	Stock availability	29 publicly available
Also Known As	l(2)02353, Dm2-MMP, dmmp2
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	45F6-46A1	Sequence location	2R:5,498,644..5,571,363 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Matrix metalloproteinase 2 is referred to in FlyBase by the symbol Dmel\Mmp2 (CG1794, FBgn0033438). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: metalloendopeptidase activity. There is experimental evidence for 12 unique biological process terms, many of which group under: single-organism developmental process; open tracheal system development; system development; cellular process; cellular component organization or biogenesis; biological regulation; post-embryonic organ morphogenesis; instar larval or pupal morphogenesis; wound healing; cell fate commitment; multicellular organism reproduction. 119 alleles are reported. The phenotypes of these alleles are annotated with: interommatidial bristle; adult thorax; ommatidium. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Hemopexin-like domain; Hemopexin-like repeats; Metallopeptidase, catalytic domain; Peptidase M10, metallopeptidase; Peptidase M10A; Peptidase, metallopeptidase; Peptidoglycan binding-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1623299_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Mmp2. Gene sequence location is 2R:5498644..5571363.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 45F6-46A1   Limits computationally determined from genome sequence between P{lacW}l(2)k09501k09501 and P{PZ}Mmp202353&P{PZ}Uba105642
Experimentally Determined Cytological Location
Cytogenetic map Notes References 46A1-46A2   (determined by in situ hybridisation)   (Spradling et al., 1999) 46A1-46A2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mmp2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mmp2-RB FBtr0088501  NM_206066   4156   758 Mmp2-RC FBtr0334807  NM_001273901   3412   606 Mmp2-RD FBtr0334808  NM_136667   3684   650
Additional Transcript Data & Comments
Reported size (kB)	3.4 (sequence analysis) (Llano et al., 2002)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mmp2-PB   FBpp0087585   89.1   758   8.81     NP_995788   AAS64885 Mmp2-PC   FBpp0306848   72.1   606   8.74     NP_001260830   AGB93363 Mmp2-PD   FBpp0306849   77.3   650   9.25     NP_610511   AAF58911
Additional Polypeptide Data & Comments
Reported size (kDa)	758 (aa); 89 (kD predicted) (Llano et al., 2002)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Hemopexin-like repeats (IPR018487) Hemopexin-like domain (IPR000585) Peptidase M10, metallopeptidase (IPR001818) Peptidoglycan binding-like (IPR002477) Peptidase, metallopeptidase (IPR006026) Metallopeptidase, catalytic domain (IPR024079) Peptidase M10A (IPR021190)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58911   AE013599 AAS64885   AE013599 AGB93363   AI109935   AI238523   AI294722   AI387739   AI532094   AJ289232 CAC81969   AW944309   AX093960   AZ933385   BI229807   BI230861   BI369040   BI637095   BI639840   BT021212 AAX33360   BZ286233   CK132287   CK661702   CL632178   CO155412   CO178156   CO185868   CO189539   CO282410   CO283561   CO287313   CO287436   CO289742   CO291791   CO300635   CO301822   CO303724   CO304901   CO328267   CO340434   CO344359   CO344542   CO344676   CZ472361   CZ472734   CZ477135   CZ477136   CZ477528   CZ477663   CZ478317   CZ481044   CZ484560   CZ484681   CZ484682   CZ484918   CZ484919   CZ487779   CZ487780   CZ490253   DN154256   EC059098   EC062733   EC194691   EC195766   EC199601   EC201338   EC202294   EC210119   EC218305   EC219159   EC232752   EC234505   EC255113   EC255131   EC255410   EC255653   EC262922   EL875216   EL875217   EL884073   EL884189   EV600041   G00598
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MPP3 Q5BIL2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & pupal stage     (Llano et al., 2002) third instar larval stage   lamina   (Llano et al., 2002) wing disc   (Llano et al., 2002) embryonic/larval optic lobe   (Llano et al., 2002) morphogenetic furrow | posterior to   (Llano et al., 2002) eye disc   (Llano et al., 2002) adult stage | female     (Llano et al., 2002) adult stage | male     (Llano et al., 2002)
Additional Descriptive Data
	Mmp2 transcripts are detected in embryos, larvae, pupae, and adult males and females by RT-PCR. They are not detected by northern blot. They are observed by in situ hybridization in third instar larval imaginal discs and brain. Strong expression is seen in the eye disc behind the morphogenetic furrow and in the lamina. (Llano et al., 2002)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
	Mmp2 protein localizes to the cell membrane. (Llano et al., 2002)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
dendrite inferred from mutant phenotype (Kuo et al., 2005) plasma membrane inferred from direct assay (Llano et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    49.6 Larval Midgut    13 Larval Hindgut    5.8 Larval Malpighian Tubules    3 Larval Fat Body    14.5 Larval Salivary Gland    1 Larval Trachea    7.4 Larval Carcass    23.375 Adult Head    31.1 Adult Eye    15.325 Adult Brain    90.7 Adult Thoracic-Abdominal Ganglion    51.9 Adult Crop    17.3 Adult Midgut    16.2 Adult Hindgut    6.5 Adult Malpighian Tubules    3.7 Adult Fat Body    3.9 Adult Salivary Gland    14.1 Adult Heart    7.675 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    6 Adult Testis    3.8 Adult Male Accessory Gland    4.2 Adult Carcass    11.1 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    49.6 Larval Midgut    13 Larval Hindgut    5.8 Larval Malpighian Tubules    3 Larval Fat Body    14.5 Larval Salivary Gland    1 Larval Trachea    7.4 Larval Carcass    23.375 Adult Head    31.1 Adult Eye    15.325 Adult Brain    90.7 Adult Thoracic-Abdominal Ganglion    51.9 Adult Crop    17.3 Adult Midgut    16.2 Adult Hindgut    6.5 Adult Malpighian Tubules    3.7 Adult Fat Body    3.9 Adult Salivary Gland    14.1 Adult Heart    7.675 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    6 Adult Testis    3.8 Adult Male Accessory Gland    4.2 Adult Carcass    11.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    49.6 Larval Midgut    13 Larval Hindgut    5.8 Larval Malpighian Tubules    3 Larval Fat Body    14.5 Larval Salivary Gland    1 Larval Trachea    7.4 Larval Carcass    23.375 Adult Head    31.1 Adult Eye    15.325 Adult Brain    90.7 Adult Thoracic-Abdominal Ganglion    51.9 Adult Crop    17.3 Adult Midgut    16.2 Adult Hindgut    6.5 Adult Malpighian Tubules    3.7 Adult Fat Body    3.9 Adult Salivary Gland    14.1 Adult Heart    7.675 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    6 Adult Testis    3.8 Adult Male Accessory Gland    4.2 Adult Carcass    11.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    49.6 Larval Midgut    13 Larval Hindgut    5.8 Larval Malpighian Tubules    3 Larval Fat Body    14.5 Larval Salivary Gland    1 Larval Trachea    7.4 Larval Carcass    23.375 Adult Head    31.1 Adult Eye    15.325 Adult Brain    90.7 Adult Thoracic-Abdominal Ganglion    51.9 Adult Crop    17.3 Adult Midgut    16.2 Adult Hindgut    6.5 Adult Malpighian Tubules    3.7 Adult Fat Body    3.9 Adult Salivary Gland    14.1 Adult Heart    7.675 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    6 Adult Testis    3.8 Adult Male Accessory Gland    4.2 Adult Carcass    11.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    49.6 Larval Midgut    13 Larval Hindgut    5.8 Larval Malpighian Tubules    3 Larval Fat Body    14.5 Larval Salivary Gland    1 Larval Trachea    7.4 Larval Carcass    23.375 Adult Head    31.1 Adult Eye    15.325 Adult Brain    90.7 Adult Thoracic-Abdominal Ganglion    51.9 Adult Crop    17.3 Adult Midgut    16.2 Adult Hindgut    6.5 Adult Malpighian Tubules    3.7 Adult Fat Body    3.9 Adult Salivary Gland    14.1 Adult Heart    7.675 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    6 Adult Testis    3.8 Adult Male Accessory Gland    4.2 Adult Carcass    11.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    49.6 Larval Midgut    13 Larval Hindgut    5.8 Larval Malpighian Tubules    3 Larval Fat Body    14.5 Larval Salivary Gland    1 Larval Trachea    7.4 Larval Carcass    23.375 Adult Head    31.1 Adult Eye    15.325 Adult Brain    90.7 Adult Thoracic-Abdominal Ganglion    51.9 Adult Crop    17.3 Adult Midgut    16.2 Adult Hindgut    6.5 Adult Malpighian Tubules    3.7 Adult Fat Body    3.9 Adult Salivary Gland    14.1 Adult Heart    7.675 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    6 Adult Testis    3.8 Adult Male Accessory Gland    4.2 Adult Carcass    11.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    49.6 Larval Midgut    13 Larval Hindgut    5.8 Larval Malpighian Tubules    3 Larval Fat Body    14.5 Larval Salivary Gland    1 Larval Trachea    7.4 Larval Carcass    23.375 Adult Head    31.1 Adult Eye    15.325 Adult Brain    90.7 Adult Thoracic-Abdominal Ganglion    51.9 Adult Crop    17.3 Adult Midgut    16.2 Adult Hindgut    6.5 Adult Malpighian Tubules    3.7 Adult Fat Body    3.9 Adult Salivary Gland    14.1 Adult Heart    7.675 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    6 Adult Testis    3.8 Adult Male Accessory Gland    4.2 Adult Carcass    11.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    49.6 Larval Midgut    13 Larval Hindgut    5.8 Larval Malpighian Tubules    3 Larval Fat Body    14.5 Larval Salivary Gland    1 Larval Trachea    7.4 Larval Carcass    23.375 Adult Head    31.1 Adult Eye    15.325 Adult Brain    90.7 Adult Thoracic-Abdominal Ganglion    51.9 Adult Crop    17.3 Adult Midgut    16.2 Adult Hindgut    6.5 Adult Malpighian Tubules    3.7 Adult Fat Body    3.9 Adult Salivary Gland    14.1 Adult Heart    7.675 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.9 Adult Ovary    6 Adult Testis    3.8 Adult Male Accessory Gland    4.2 Adult Carcass    11.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    31.1   NA  Eye    15.325   NA  Brain    90.7   49.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    51.9   NA  Crop    17.3   no informative data  Midgut    no informative data   5.8  Hindgut    6.5   3  Malpighian Tubules    3.7   no informative data  Fat Body    3.9   1  Salivary Gland    no informative data   NA  Heart    7.675   7.4  Trachea    NA   NA  VirginFemale Spermatheca    1.4   NA  InseminatedFemale Spermatheca    2.9   NA  Ovary    6   NA  Testis    3.8   NA  Male Accessory Gland    4.2   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    57 central nervous system, pupae P8    80 head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    14 head, mated 20-day female    11 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    24 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    105 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    121 fat body, pupae P8    49 carcass, larvae L3 wandering    39 carcass, 1-day adult    5 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3  (57) central nervous system, pupae P8  (80) head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    14 head, mated 20-day female    11 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    24 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (105) digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae  (121) fat body, pupae P8  (49) carcass, larvae L3 wandering  (39) carcass, 1-day adult    5 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    57 central nervous system, pupae P8    80 head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    14 head, mated 20-day female    11 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    24 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  105 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae  (121) fat body, pupae P8    49 carcass, larvae L3 wandering    39 carcass, 1-day adult    5 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    57 central nervous system, pupae P8    80 head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    14 head, mated 20-day female    11 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    24 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    105 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    121 fat body, pupae P8    49 carcass, larvae L3 wandering    39 carcass, 1-day adult    5 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    57 central nervous system, pupae P8    80 head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    14 head, mated 20-day female    11 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    24 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    105 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    121 fat body, pupae P8    49 carcass, larvae L3 wandering    39 carcass, 1-day adult    5 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3  (57) central nervous system, pupae P8  (80) head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    14 head, mated 20-day female    11 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    24 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (105) digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae  (121) fat body, pupae P8  (49) carcass, larvae L3 wandering  (39) carcass, 1-day adult    5 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    57 central nervous system, pupae P8    80 head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    14 head, mated 20-day female    11 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    24 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  105 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae  121 fat body, pupae P8    49 carcass, larvae L3 wandering    39 carcass, 1-day adult    5 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    57 central nervous system, pupae P8    80 head, virgin 1-day female    17 head, virgin 4-day female    13 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    14 head, mated 20-day female    11 head, mated 1-day male    24 head, mated 4-day male    23 head, mated 20-day male    24 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    105 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    121 fat body, pupae P8    49 carcass, larvae L3 wandering    39 carcass, 1-day adult    5 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    11 embryo 10-12hr    15 embryo 12-14hr    17 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    8 larva L1    6 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    30 white prepupae new    69 white prepupae 12hr    100 white prepupae 24hr    53 pupae 2d postWPP    36 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    9 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    11 embryo 10-12hr    15 embryo 12-14hr    17 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    8 larva L1    6 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9  (30) white prepupae new  (69) white prepupae 12hr  (100) white prepupae 24hr  (53) pupae 2d postWPP  (36) pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    9 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    11 embryo 10-12hr    15 embryo 12-14hr    17 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    8 larva L1    6 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    30 white prepupae new    69 white prepupae 12hr    100 white prepupae 24hr    53 pupae 2d postWPP    36 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    9 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    11 embryo 10-12hr    15 embryo 12-14hr    17 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    8 larva L1    6 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    30 white prepupae new    69 white prepupae 12hr    100 white prepupae 24hr    53 pupae 2d postWPP    36 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    9 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    3 adult female 30day    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    11 embryo 10-12hr    15 embryo 12-14hr    17 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    8 larva L1    6 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    30 white prepupae new    69 white prepupae 12hr    100 white prepupae 24hr    53 pupae 2d postWPP    36 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    9 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    11 embryo 10-12hr    15 embryo 12-14hr    17 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    8 larva L1    6 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9  30 white prepupae new  (69) white prepupae 12hr  (100) white prepupae 24hr  (53) pupae 2d postWPP  (36) pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    9 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    11 embryo 10-12hr    15 embryo 12-14hr    17 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    8 larva L1    6 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    30 white prepupae new    69 white prepupae 12hr    100 white prepupae 24hr    53 pupae 2d postWPP    36 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    9 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    11 embryo 10-12hr    15 embryo 12-14hr    17 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    6 embryo 22-24hr    8 larva L1    6 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    30 white prepupae new    69 white prepupae 12hr    100 white prepupae 24hr    53 pupae 2d postWPP    36 pupae 3d postWPP    13 pupae 4d postWPP    11 adult male 01day    9 adult male 05day    4 adult male 30day    4 adult female 01day    7 adult female 05day    3 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    81 Schneider line 2 Sg4    8 embryonic 1182-4H    81 embryonic GM2    84 embryonic Kc167    3 embryonic S1    6 embryonic S3    8 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    69 wing disc ML-DmD9    103 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    58 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    47 ovary fGS/OSS    6 ovary OSC    4 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (81) Schneider line 2 Sg4    8 embryonic 1182-4H  (81) embryonic GM2  (84) embryonic Kc167    3 embryonic S1    6 embryonic S3    8 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8  (69) wing disc ML-DmD9  (103) wing disc ML-DmD16-c3  (60) wing disc ML-DmD21  (58) wing disc ML-DmD32  (29) haltere disc ML-DmD17-c3  (53) eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1  (48) CNS ML-DmBG1-c1  (38) CNS ML-DmBG2-c2    12 tumorous blood cells mbn2  (47) ovary fGS/OSS    6 ovary OSC    4 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    81 Schneider line 2 Sg4    8 embryonic 1182-4H    81 embryonic GM2    84 embryonic Kc167    3 embryonic S1    6 embryonic S3    8 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    69 wing disc ML-DmD9  103 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    58 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    47 ovary fGS/OSS    6 ovary OSC    4 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    81 Schneider line 2 Sg4    8 embryonic 1182-4H    81 embryonic GM2    84 embryonic Kc167    3 embryonic S1    6 embryonic S3    8 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    69 wing disc ML-DmD9    103 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    58 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    47 ovary fGS/OSS    6 ovary OSC    4 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    81 Schneider line 2 Sg4    8 embryonic 1182-4H    81 embryonic GM2    84 embryonic Kc167    3 embryonic S1    6 embryonic S3    8 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    69 wing disc ML-DmD9    103 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    58 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    47 ovary fGS/OSS    6 ovary OSC    4 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (81) Schneider line 2 Sg4    8 embryonic 1182-4H  (81) embryonic GM2  (84) embryonic Kc167    3 embryonic S1    6 embryonic S3    8 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8  (69) wing disc ML-DmD9  (103) wing disc ML-DmD16-c3  (60) wing disc ML-DmD21  (58) wing disc ML-DmD32  29 haltere disc ML-DmD17-c3  (53) eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1  (48) CNS ML-DmBG1-c1  (38) CNS ML-DmBG2-c2    12 tumorous blood cells mbn2  (47) ovary fGS/OSS    6 ovary OSC    4 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    81 Schneider line 2 Sg4    8 embryonic 1182-4H    81 embryonic GM2    84 embryonic Kc167    3 embryonic S1    6 embryonic S3    8 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    69 wing disc ML-DmD9  103 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    58 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    47 ovary fGS/OSS    6 ovary OSC    4 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    81 Schneider line 2 Sg4    8 embryonic 1182-4H    81 embryonic GM2    84 embryonic Kc167    3 embryonic S1    6 embryonic S3    8 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    69 wing disc ML-DmD9    103 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    58 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    53 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    47 ovary fGS/OSS    6 ovary OSC    4 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    29 cold shock, 4-day adult    29 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (29) cold shock, 4-day adult  (29) heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    29 cold shock, 4-day adult    29 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    29 cold shock, 4-day adult    29 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    29 cold shock, 4-day adult    29 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  29 cold shock, 4-day adult  29 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    29 cold shock, 4-day adult    29 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    29 cold shock, 4-day adult    29 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_25 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033438 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1794-RA;HDC05455
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage, with Scer\GAL4Cg.PA Mmp2Scer\UAS.cPa lethal | pupal stage Mmp2A218V Mmp2W307stop lethal | pupal stage (with Df(2R)Uba1-Mmp2) Mmp2W307stop lethal | pupal stage (with Mmp2A218V) Mmp2Df lethal | pupal stage (with Mmp2Df) Mmp2A218V Mmp2G535R Mmp2W307stop lethal | pupal stage (with Mmp2G535R) Mmp2Df lethal | pupal stage (with Mmp2W307stop) Mmp2Df lethal | recessive Mmp202353 Mmp205865 Mmp2k00604 Mmp2k00613 Mmp2k01002 Mmp2k06015 Mmp2k07511 Mmp2rK357 Mmp2rP247 partially lethal - majority die, with Scer\GAL4yolk Mmp2Scer\UAS.cPa partially lethal - majority die | larval stage Mmp2W307stop partially lethal - majority die | pupal stage (with Mmp2Df) Mmp2F219I partially lethal - majority die | pupal stage (with Mmp2F219I) Mmp2Df Sterility Allele sterile, with Scer\GAL4yolk Mmp2Scer\UAS.cPa Other Phenotypes Allele hyperplasia | third instar larval stage, with Scer\GAL4ap-md544 Mmp2dsRNA.Scer\UAS melanotic mass phenotype | pupal stage (with Mmp2Df) Mmp2G535R melanotic mass phenotype | pupal stage (with Mmp2G535R) Mmp2Df neuroanatomy defective | embryonic stage Mmp2W307stop neuroanatomy defective | embryonic stage, with Scer\GAL4repo.PU Mmp2Scer\UAS.cPa neuroanatomy defective | pupal stage Mmp2W307stop Phenotype manifest in Allele adult thorax, with Scer\GAL4pnr-MD237 Mmp2dsRNA.Scer\UAS basement membrane | pupal stage Mmp2k00604 dendritic arborizing neuron | P-stage Mmp2W307stop dorsal air sac primordium | third instar larval stage Mmp2W307stop dorsal air sac primordium | third instar larval stage, with Scer\GAL4ap-md544 Mmp2dsRNA.Scer\UAS dorsal air sac primordium | third instar larval stage, with Scer\GAL4btl.PS Mmp2dsRNA.Scer\UAS dorsal air sac primordium tip cell | third instar larval stage | heat sensitive, with Scer\GAL4btl.PS, Scer\GAL80ts.αTub84B Mmp2dsRNA.Scer\UAS.cWa embryonic/larval proventriculus | P-stage Mmp2W307stop embryonic/larval transverse connective | third instar larval stage Mmp2W307stop embryonic/larval transverse connective | third instar larval stage, with Scer\GAL4btl.PS Mmp2dsRNA.Scer\UAS gastric caecum | P-stage Mmp2W307stop head | pupal stage (with Df(2R)Uba1-Mmp2) Mmp2W307stop interommatidial bristle, with Scer\GAL4GMR.PF Mmp2Scer\UAS.cPa intersegmental nerve branch ISNb of A1-7 | embryonic stage Mmp2W307stop intersegmental nerve branch ISNb of A1-7 | embryonic stage, with Scer\GAL4repo.PU Mmp2Scer\UAS.cPa leg | pupal stage Mmp2k00604 mesothoracic tergum | pharate adult stage Mmp2A218V ommatidium, with Scer\GAL4GMR.PF Mmp2Scer\UAS.cPa segmental nerve branch SNa of A1-7 | embryonic stage, with Scer\GAL4repo.PU Mmp2Scer\UAS.cPa tracheal air sac | third instar larval stage | heat sensitive, with Scer\GAL4btl.PS, Scer\GAL80ts.αTub84B Mmp2dsRNA.Scer\UAS.cWa wing | pupal stage Mmp2k00604 wing disc | third instar larval stage Mmp2W307stop wing disc | third instar larval stage, with Scer\GAL4btl.PS Mmp2dsRNA.Scer\UAS
Classical Alleles ( 111 )
For All Classical Alleles Show
Allele of Mmp2 Class Mutagen Stocks Known lesion Mmp2k00604 P-element activity 2 -- Mmp202353 P-element activity 1 -- Mmp25-HA-2268 1 -- Mmp2BG00958 P-element activity 1 -- Mmp2c03509 1 -- Mmp2d01654 P-element activity 1 -- Mmp2d02296 P-element activity 1 -- Mmp2d10173 P-element activity 1 -- Mmp2d11062 P-element activity 1 -- Mmp2d11288 P-element activity 1 -- Mmp2DG24601 1 -- Mmp2e00430 piggyBac transposase 1 -- Mmp2e03275 piggyBac transposase 1 -- Mmp2EY08942 P-element activity 1 -- Mmp2f02065 piggyBac transposase 1 -- Mmp2f02173 piggyBac transposase 1 -- Mmp2f02410 piggyBac transposase 1 -- Mmp2f05155 piggyBac transposase 1 -- Mmp2f07513 piggyBac transposase 1 -- Mmp2KG01263 P-element activity 1 -- Mmp2MI00489 1 -- Mmp2MI02914 1 -- Mmp2MI03429 1 -- Mmp2NP0509 1 -- Mmp2NP3013 1 -- Mmp2UM-8243-3 1 -- Mmp201D09Y-K007 0 -- Mmp201D09Y-M002 0 -- Mmp201D09Y-M005 0 -- Mmp201D09Y-M007 0 -- Mmp201D09Y-M012 0 -- Mmp201D09Y-M014 0 -- Mmp201D09Y-M025 0 -- Mmp201D09Y-M032 0 -- Mmp201D09Y-M033 0 -- Mmp201D09Y-M045 0 -- Mmp201D09Y-M055 0 -- Mmp201D09Y-M060 0 -- Mmp201D09Y-M062 0 -- Mmp201D09Y-M064 0 -- Mmp201D09Y-M067 0 -- Mmp201D09Y-M068 0 -- Mmp201D09Y-M071 0 -- Mmp201D09Y-M078 0 -- Mmp201D09Y-M079 0 -- Mmp201D09Y-M080 0 -- Mmp201D09Y-M082 0 -- Mmp201D09Y-M088 0 -- Mmp201D09Y-M089 0 -- Mmp201D09Y-M095 0 -- Mmp201D09Y-M100 0 -- Mmp201D09Y-M102 0 -- Mmp201D09Y-M109 0 -- Mmp201D09Y-M110 0 -- Mmp201D09Y-M113 0 -- Mmp201D09Y-M114 0 -- Mmp201D09Y-M116 0 -- Mmp201D09Y-M117 0 -- Mmp201D09Y-M124 0 -- Mmp201D09Y-M126 0 -- Mmp201D09Y-M129 0 -- Mmp201D09Y-M137 0 -- Mmp201D09Y-M138 0 -- Mmp201D09Y-M146 0 -- Mmp201D09Y-M147 0 -- Mmp201D09Y-M149 0 -- Mmp201D09Y-M150 0 -- Mmp201D09Y-M155 0 -- Mmp201D09Y-M157 0 -- Mmp201D09Y-M158 0 -- Mmp201D09Y-M164 0 -- Mmp201D09Y-M165 0 -- Mmp201D09Y-M167 0 -- Mmp201D09Y-M169 0 -- Mmp201D09Y-M173 0 -- Mmp201D09Y-M175 0 -- Mmp201D09Y-M176 0 -- Mmp201D09Y-M180 0 -- Mmp201D09Y-M181 0 -- Mmp201D09Y-M184 0 -- Mmp201D09Y-M189 0 -- Mmp201D09Y-M190 0 -- Mmp201D09Y-M193 0 -- Mmp201D09Y-M194 0 -- Mmp201D09Y-M195 0 -- Mmp201D09Y-M196 0 -- Mmp201D09Y-M200 0 -- Mmp201D09Y-M204 0 -- Mmp201D09Y-M205 0 -- Mmp201D09Y-M206 0 -- Mmp201D09Y-M207 0 -- Mmp201D09Y-M210 0 -- Mmp201D09Y-M213 0 -- Mmp201D09Y-M214 0 -- Mmp201D09Y-M216 0 -- Mmp205865 P-element activity 0 -- Mmp2218 ethyl methanesulfonate 0 Yes Mmp2A218V ethyl methanesulfonate 0 Yes Mmp2d08891 0 -- Mmp2Df P-element activity 0 Yes Mmp2DG16407 0 -- Mmp2F219I ethyl methanesulfonate 0 Yes Mmp2G535R ethyl methanesulfonate 0 Yes Mmp2k00613 P-element activity 0 -- Mmp2k01002 P-element activity 0 -- Mmp2k06015 P-element activity 0 -- Mmp2k07511 P-element activity 0 -- Mmp2rK357 P-element activity 0 -- Mmp2rP247 P-element activity 0 -- Mmp2SH2100 0 -- Mmp2W307stop loss of function allele ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mmp2 Class Mutagen Stocks Known lesion Mmp2JF01337 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mmp2KK104713 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mmp2dsRNA.Scer\UAS.cWa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Mmp2dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Mmp2GD9489 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Mmp2MtnA.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mmp2NIG.1794-1R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Mmp2Scer\UAS.cPa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)B5 (BDGP Project Members, 1994-1999) Df(2R)Np4 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Np5 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(2R)BSC132 (Christensen and Cook, 2005.12.14) Df(2R)Uba1-Mmp2 (Page-McCaw et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9489} NA P{KK104713} NA P{NIG.1794-1R} NA P{TRiP.JF01337} NA P{UAS-Mmp2.dsRNA.W} NA P{UAS-Mmp2.P} NA P{UAS-Mmp2.RNAi} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Mmp2EY08942 NA P{XP}Mmp2d01654 NA P{XP}Mmp2d02296 NA P{XP}Mmp2d08891 NA P{XP}Mmp2d10173 NA P{XP}Mmp2d11062 NA P{XP}Mmp2d11288 NA miscellaneous insertions Mi{MIC}Mmp2MI00489 NA Mi{MIC}Mmp2MI02914 NA Mi{MIC}Mmp2MI03429 NA P{3'wHy}Mmp201D09Y-K007 NA P{3'wHy}Mmp201D09Y-M002 NA P{3'wHy}Mmp201D09Y-M005 NA P{3'wHy}Mmp201D09Y-M007 NA P{3'wHy}Mmp201D09Y-M012 NA P{3'wHy}Mmp201D09Y-M014 NA P{3'wHy}Mmp201D09Y-M025 NA P{3'wHy}Mmp201D09Y-M032 NA P{3'wHy}Mmp201D09Y-M033 NA P{3'wHy}Mmp201D09Y-M045 NA P{3'wHy}Mmp201D09Y-M055 NA P{3'wHy}Mmp201D09Y-M060 NA P{3'wHy}Mmp201D09Y-M062 NA P{3'wHy}Mmp201D09Y-M064 NA P{3'wHy}Mmp201D09Y-M067 NA P{3'wHy}Mmp201D09Y-M068 NA P{3'wHy}Mmp201D09Y-M071 NA P{3'wHy}Mmp201D09Y-M078 NA P{3'wHy}Mmp201D09Y-M079 NA P{3'wHy}Mmp201D09Y-M080 NA P{3'wHy}Mmp201D09Y-M082 NA P{3'wHy}Mmp201D09Y-M088 NA P{3'wHy}Mmp201D09Y-M089 NA P{3'wHy}Mmp201D09Y-M095 NA P{3'wHy}Mmp201D09Y-M100 NA P{3'wHy}Mmp201D09Y-M102 NA P{3'wHy}Mmp201D09Y-M109 NA P{3'wHy}Mmp201D09Y-M110 NA P{3'wHy}Mmp201D09Y-M113 NA P{3'wHy}Mmp201D09Y-M114 NA P{3'wHy}Mmp201D09Y-M116 NA P{3'wHy}Mmp201D09Y-M117 NA P{3'wHy}Mmp201D09Y-M124 NA P{3'wHy}Mmp201D09Y-M126 NA P{3'wHy}Mmp201D09Y-M129 NA P{3'wHy}Mmp201D09Y-M137 NA P{3'wHy}Mmp201D09Y-M138 NA P{3'wHy}Mmp201D09Y-M146 NA P{3'wHy}Mmp201D09Y-M147 NA P{3'wHy}Mmp201D09Y-M149 NA P{3'wHy}Mmp201D09Y-M150 NA P{3'wHy}Mmp201D09Y-M155 NA P{3'wHy}Mmp201D09Y-M157 NA P{3'wHy}Mmp201D09Y-M158 NA P{3'wHy}Mmp201D09Y-M164 NA P{3'wHy}Mmp201D09Y-M165 NA P{3'wHy}Mmp201D09Y-M167 NA P{3'wHy}Mmp201D09Y-M169 NA P{3'wHy}Mmp201D09Y-M173 NA P{3'wHy}Mmp201D09Y-M175 NA P{3'wHy}Mmp201D09Y-M176 NA P{3'wHy}Mmp201D09Y-M180 NA P{3'wHy}Mmp201D09Y-M181 NA P{3'wHy}Mmp201D09Y-M184 NA P{3'wHy}Mmp201D09Y-M189 NA P{3'wHy}Mmp201D09Y-M190 NA P{3'wHy}Mmp201D09Y-M193 NA P{3'wHy}Mmp201D09Y-M194 NA P{3'wHy}Mmp201D09Y-M195 NA P{3'wHy}Mmp201D09Y-M196 NA P{3'wHy}Mmp201D09Y-M200 NA P{3'wHy}Mmp201D09Y-M204 NA P{3'wHy}Mmp201D09Y-M205 NA P{3'wHy}Mmp201D09Y-M206 NA P{3'wHy}Mmp201D09Y-M207 NA P{3'wHy}Mmp201D09Y-M210 NA P{3'wHy}Mmp201D09Y-M213 NA P{3'wHy}Mmp201D09Y-M214 NA P{3'wHy}Mmp201D09Y-M216 NA P{GT1}Mmp2BG00958 NA P{RS3}Mmp2UM-8243-3 NA P{RS5}Mmp25-HA-2268 NA P{SUPor-P}Mmp2KG01263 NA P{wHy}Mmp2DG24601 NA PBac{PB}Mmp2c03509 NA PBac{RB}Mmp2e00430 NA PBac{RB}Mmp2e03275 NA PBac{WH}Mmp2f02065 NA PBac{WH}Mmp2f02173 NA PBac{WH}Mmp2f02410 NA PBac{WH}Mmp2f05155 NA PBac{WH}Mmp2f07513 NA insertion of enhancer trap binary system P{GawB}Mmp2NP0509 No P{GawB}Mmp2NP3013 No insertion of enhancer trap P{lacW}l(2)SH0610SH0610 No P{lacW}Mmp2k00604 No P{lacW}Mmp2k00613 No P{lacW}Mmp2k01002 No P{lacW}Mmp2k06015 No P{lacW}Mmp2k07511 No P{lacW}Mmp2SH2100 No P{PZ}Mmp202353 No P{PZ}Mmp205865 No P{PZ}Mmp2rK357 No P{PZ}Mmp2rP247 No
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
metalloendopeptidase activity inferred from direct assay (Llano et al., 2002)
Biological Process
CV term Evidence References
activation of innate immune response inferred from direct assay (Schmidt et al., 2011) basement membrane disassembly inferred from mutant phenotype (Srivastava et al., 2007) basement membrane organization inferred from mutant phenotype (Guha et al., 2009) imaginal disc eversion inferred from mutant phenotype (Srivastava et al., 2007) imaginal disc fusion, thorax closure inferred from mutant phenotype (Uhlirova and Bohmann, 2006) lateral inhibition inferred from mutant phenotype (Wang et al., 2010) negative regulation of fibroblast growth factor receptor signaling pathway inferred from direct assay (Wang et al., 2010) oogenesis inferred from mutant phenotype (Page-McCaw et al., 2002) open tracheal system development inferred from mutant phenotype (Wang et al., 2010) tracheal outgrowth, open tracheal system inferred from mutant phenotype (Guha et al., 2009) tracheal pit formation in open tracheal system inferred from mutant phenotype (Guha et al., 2009) wound healing inferred from mutant phenotype (Stevens and Page-McCaw, 2012)
Cellular Component
CV term Evidence References
dendrite inferred from mutant phenotype (Kuo et al., 2005) plasma membrane inferred from direct assay (Llano et al., 2002)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
metalloendopeptidase activity inferred from sequence or structural similarity with UniProtKB:Q11005 (FlyBase, 1992-) non-traceable author statement (Page-McCaw et al., 2002) zinc ion binding inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR006026, InterPro:IPR021190 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR006026, InterPro:IPR021190 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
extracellular matrix inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR021190 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Mmp2 - frac two hybrid (Miller et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mmp2 allele Gene References Mmp2Scer\UAS.cPa Timp (Page-McCaw et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61828 DroID - A comprehensive database of gene and protein interactions. • FBgn0033438 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35997
Orthologs
OrthoDB Orthologs (167) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BP1XD Dipteran inclusive ortholog search EOG6HQDSN Insect inclusive ortholog search EOG6TDZG2 Arthropod inclusive ortholog search EOG6Q83D5 Metazoa inclusive ortholog search EOG6BKHX2
Orthologs in Drosophila Species (EOG6BP1XD)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Mmp2     Drosophila simulans   Dsim\GD10058 Y   Drosophila sechellia   Dsec\GM20587 Y   Drosophila erecta   Dere\GG25269 Y   Drosophila yakuba   Dyak\GE22137 Y   Drosophila ananassae   Dana\GF11488 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA24215 Y   Drosophila persimilis   Dper\GL17329 Y   Drosophila willistoni   Dwil\GK15621 Y   Drosophila virilis   Dvir\GJ20836 Y   Drosophila mojavensis   Dmoj\GI21232 Y   Drosophila grimshawi   Dgri\GH22855 Y
Orthologs in non-Drosophila Dipterans (EOG6HQDSN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000788   Anopheles gambiae Malaria mosquito  Agam\AGAP011870   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001428
Orthologs in non-Dipteran Insects (EOG6TDZG2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB40857   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004063   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004061   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13609   Atta cephalotes Leafcutter ant  Acep\ACEP16890   Camponotus floridanus Florida carpenter ant  Cflo\CFLO11088   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19895   Linepithema humile Argentine ant  Lhum\LH18932   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12543   Solenopsis invicta Red fire ant  Sinv\SINV10468   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003426   Bombyx mori Silkmoth  Bmor\BGIBMGA005310   Pediculus humanus Human body louse  Phum\PHUM000210   Tribolium castaneum Red flour beetle  Tcas\Mmp2
Orthologs in non-Insect Arthropods (EOG6Q83D5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\psbA   Daphnia pulex Water flea  Dpux\JGI_V11_326457   Ixodes scapularis Deer tick  Isca\ISCW024483   Ixodes scapularis Deer tick  Isca\ISCW022900
Orthologs in non-Arthropod Metazoa (EOG6BKHX2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\zmp-1 Y Caenorhabditis elegans Nematode  Cele\H36L18.1 Y Caenorhabditis elegans Nematode  Cele\H19M22.3 Y Caenorhabditis elegans Nematode  Cele\T21D11.1 Y Caenorhabditis elegans Nematode  Cele\C31B8.8 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005576gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002029gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013670gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018472gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027328gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027604gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005723gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018156gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005385gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024003gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013669gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009925gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005577gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028749gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025345gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003703gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007980gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006014gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012549gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009924gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019540gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028748gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000567gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000566gn Y Danio rerio Zebrafish  Drer\CR848664.1 Y Danio rerio Zebrafish  Drer\mmp24 Y Danio rerio Zebrafish  Drer\ENSDARG00000013072 Y Danio rerio Zebrafish  Drer\CABZ01030094.1 Y Danio rerio Zebrafish  Drer\ENSDARG00000077290 Y Danio rerio Zebrafish  Drer\mmp14a Y Danio rerio Zebrafish  Drer\CABZ01029422.1 Y Danio rerio Zebrafish  Drer\ENSDARG00000087801 Y Danio rerio Zebrafish  Drer\mmp13b Y Danio rerio Zebrafish  Drer\mmp16b Y Danio rerio Zebrafish  Drer\ENSDARG00000089887 Y Danio rerio Zebrafish  Drer\mmp14b Y Danio rerio Zebrafish  Drer\mmp16a Y Danio rerio Zebrafish  Drer\ENSDARG00000059029 Y Danio rerio Zebrafish  Drer\mmp11b Y Danio rerio Zebrafish  Drer\ENSDARG00000051962 Y Danio rerio Zebrafish  Drer\OTTDARG00000028175 Y Danio rerio Zebrafish  Drer\ENSDARG00000091557 Y Danio rerio Zebrafish  Drer\mmp17a Y Danio rerio Zebrafish  Drer\mmp13a Y Danio rerio Zebrafish  Drer\mmp11a Y Xenopus tropicalis Western clawed frog  Xtro\mmp28 Y Xenopus tropicalis Western clawed frog  Xtro\mmp11 Y Xenopus tropicalis Western clawed frog  Xtro\mmp3 Y Xenopus tropicalis Western clawed frog  Xtro\mmp24 Y Xenopus tropicalis Western clawed frog  Xtro\mmp8 Y Xenopus tropicalis Western clawed frog  Xtro\mmp16 Y Xenopus tropicalis Western clawed frog  Xtro\mmp25 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031108 Y Xenopus tropicalis Western clawed frog  Xtro\mmp14 Y Xenopus tropicalis Western clawed frog  Xtro\mmp13l Y Xenopus tropicalis Western clawed frog  Xtro\mmp1 Y Xenopus tropicalis Western clawed frog  Xtro\mmp17 Y Xenopus tropicalis Western clawed frog  Xtro\mmp19 Y Xenopus tropicalis Western clawed frog  Xtro\mmp13 Y Xenopus tropicalis Western clawed frog  Xtro\mmp15 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031177 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000034187 Y Gallus gallus Domestic chicken  Ggal\MMP11 Y Gallus gallus Domestic chicken  Ggal\MMP28 Y Gallus gallus Domestic chicken  Ggal\MMP16 Y Gallus gallus Domestic chicken  Ggal\MMP17 Y Gallus gallus Domestic chicken  Ggal\MMP3 Y Gallus gallus Domestic chicken  Ggal\MMP7 Y Gallus gallus Domestic chicken  Ggal\MMP27 Y Gallus gallus Domestic chicken  Ggal\MMP1 Y Gallus gallus Domestic chicken  Ggal\MMP13 Y Gallus gallus Domestic chicken  Ggal\MMP15 Y Gallus gallus Domestic chicken  Ggal\MMP24 Y Mus musculus House mouse  Mmus\Mmp25 Y Mus musculus House mouse  Mmus\Mmp15 Y Mus musculus House mouse  Mmus\Mmp13 Y Mus musculus House mouse  Mmus\Mmp1a Y Mus musculus House mouse  Mmus\Mmp27 Y Mus musculus House mouse  Mmus\Mmp24 Y Mus musculus House mouse  Mmus\Mmp10 Y Mus musculus House mouse  Mmus\Mmp17 Y Mus musculus House mouse  Mmus\Mmp11 Y Mus musculus House mouse  Mmus\Mmp8 Y Mus musculus House mouse  Mmus\Mmp28 Y Mus musculus House mouse  Mmus\Mmp1b Y Mus musculus House mouse  Mmus\Mmp7 Y Mus musculus House mouse  Mmus\Mmp16 Y Mus musculus House mouse  Mmus\Mmp19 Y Mus musculus House mouse  Mmus\Mmp14 Y Mus musculus House mouse  Mmus\Mmp20 Y Mus musculus House mouse  Mmus\Mmp3 Y Rattus norvegicus Norway rat  Rnor\Mmp15 Y Rattus norvegicus Norway rat  Rnor\Mmp1b Y Rattus norvegicus Norway rat  Rnor\Mmp10 Y Rattus norvegicus Norway rat  Rnor\Mmp8 Y Rattus norvegicus Norway rat  Rnor\Mmp17 Y Rattus norvegicus Norway rat  Rnor\Mmp3 Y Rattus norvegicus Norway rat  Rnor\Mmp28 Y Rattus norvegicus Norway rat  Rnor\Mmp19 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029621 Y Rattus norvegicus Norway rat  Rnor\Mmp7 Y Rattus norvegicus Norway rat  Rnor\Mmp27 Y Rattus norvegicus Norway rat  Rnor\Mmp20 Y Rattus norvegicus Norway rat  Rnor\Mmp14 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000005708 Y Rattus norvegicus Norway rat  Rnor\Mmp12 Y Rattus norvegicus Norway rat  Rnor\Mmp13 Y Rattus norvegicus Norway rat  Rnor\Mmp1a Y Rattus norvegicus Norway rat  Rnor\Mmp11 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000043133 Y Homo sapiens Human  Hsap\MMP7 Y Homo sapiens Human  Hsap\MMP8 Y Homo sapiens Human  Hsap\MMP12 Y Homo sapiens Human  Hsap\MMP19 Y Homo sapiens Human  Hsap\MMP11 Y Homo sapiens Human  Hsap\MMP13 Y Homo sapiens Human  Hsap\MMP3 Y Homo sapiens Human  Hsap\MMP16 Y Homo sapiens Human  Hsap\MMP26 Y Homo sapiens Human  Hsap\MMP27 Y Homo sapiens Human  Hsap\MMP24 Y Homo sapiens Human  Hsap\MMP28 Y Homo sapiens Human  Hsap\MMP14 Y Homo sapiens Human  Hsap\MMP20 Y Homo sapiens Human  Hsap\MMP17 Y Homo sapiens Human  Hsap\MMP1 Y Homo sapiens Human  Hsap\MMP15 Y Homo sapiens Human  Hsap\MMP10 Y Homo sapiens Human  Hsap\MMP25 Y
Human Orthologs (19)
Gene OMIM HGNC Hsap\MMP7     Hsap\MMP8     Hsap\MMP12     Hsap\MMP19     Hsap\MMP11     Hsap\MMP13     Hsap\MMP3     Hsap\MMP16     Hsap\MMP26     Hsap\MMP27     Hsap\MMP24     Hsap\MMP28     Hsap\MMP14     Hsap\MMP20     Hsap\MMP17     Hsap\MMP1     Hsap\MMP15     Hsap\MMP10     Hsap\MMP25
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10058 Drosophila sechellia Dsec\GM20587 Drosophila erecta Dere\GG25269 Drosophila yakuba Dyak\GE22137 Drosophila ananassae Dana\GF11488 Drosophila pseudoobscura pseudoobscura Dpse\GA24215 Drosophila persimilis Dper\GL17329 Drosophila willistoni Dwil\GK15621 Drosophila virilis Dvir\GJ20836 Drosophila mojavensis Dmoj\GI21232 Drosophila grimshawi Dgri\GH22855
Stocks & Reagents
Stocks Listed in FlyBase ( 29 )
Harvard	- P{XP}Mmp2d01654 - P{XP}Mmp2d02296 - P{XP}Mmp2d10173 - P{XP}Mmp2d11062 - P{XP}Mmp2d11288 - PBac{PB}Mmp2c03509 - PBac{RB}Mmp2e00430 - PBac{RB}Mmp2e03275 - PBac{WH}Mmp2f02065 - PBac{WH}Mmp2f02173 - PBac{WH}Mmp2f02410
VDRC	v107888 P{KK104713}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR17M11 BACR48G21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 53 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD03462
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH09340 GH14579 GH18378 LP08160 LP13690 LP21363 RE16118 RE27665 RE55121 SD19012 SD22534
Other clones	19076 19399 45054 55411 57805 74696 102347 214311.45 214313.40 214377.46 214503.46 524827 CK01.12D.H9 CK01.60C.G2 CK01.69C.A2 CK01.92A.B6 CK01.98B.B6 Dmel_neb_013758_0901_2834 EK013830 EK044506 EK055533 EK065533 EK065843 EK071939 EK160416 EK163651 EK178840 EK182244 EK198305 EK204457 EK242628 EK246706 EN06013 EP08844 EP10638 EP19128 EP19455 EP19716 IP15236 IP15436 IP15536
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033438 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35997
Antibody Information
	polyclonal (Wang et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mmp2 CG1794 (Page-McCaw, 2002.3.18)
Source for database merge of	Source for merge of: l(2)02353 Mmp2 (Page-McCaw et al., 2003) Source for merge of: Mmp2 anon-WO0118547.84 (FlyBase, 1996-)
Additional comments	Source for merge of Mmp2 anon-WO0118547.84 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Putative substrate for the kinase png. (Lee et al., 2005) Mutants are pupal lethal and show defects in oogenesis. (Page-McCaw et al., 2002) Area matching Drosophila EST AI238523. (Davies, 2001.3.15) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136667 NM_206066 NM_001273901 RefSeq (Proteins) • NP_610511 NP_995788 NP_001260830 DDBJ / EMBL / GenBank • AAF58911 AAS64885 AAX33360 AGB93363 AI238523 AI532094 AJ289232 AW944309 AX093960 AZ933385 BT021212 BZ286233 CAC81969 CL632178 CZ472361 CZ472734 CZ477135 CZ477136 CZ477528 CZ477663 CZ478317 CZ481044 CZ484560 CZ484681 CZ484682 CZ484918 CZ484919 CZ487779 CZ487780 CZ490253 G00598 Entrez Gene - A searchable database of RefSeq genes. • 35997 UniProtKB/TrEMBL • Q5BIL2 Q8MPP3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Hemopexin-like repeats (IPR018487) Hemopexin-like domain (IPR000585) Peptidase M10, metallopeptidase (IPR001818) Peptidoglycan binding-like (IPR002477) Peptidase, metallopeptidase (IPR006026) Metallopeptidase, catalytic domain (IPR024079) Peptidase M10A (IPR021190)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61828 DroID - A comprehensive database of gene and protein interactions. • FBgn0033438 DRSC - Results from RNAi screens. • FBgn0033438 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033438 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1794-RA;HDC05455 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033438 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35997 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35997 modMine - Data generated by the modENCODE project. • FBgn0033438
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	2-MMP (Santamaria, 2000.5.25) anon-WO0118547.84   CG1794 (Coates et al., 2000, Huet et al., 2002, Keleman et al., 2009.8.5, Ostrin et al., 2006, Macdonald and Long, 2006, Ni et al., 2008, Aerts et al., 2010) dm-2MMP (Wei et al., 2003) Dm2-MMP (Llano et al., 2002) DM2-MMP (Miller et al., 2010) dmmp2 (Vidal et al., 2010, Singh et al., 2010) l(2)02353 (Page-McCaw et al., 2003, Spradling et al., 1999, Roch et al., 1998, BDGP Project Members, 1994-1999, ) MMP2 (Vidal et al., 2006, Meyer et al., 2011) Mmp2 (Lee et al., 2005, Curtin et al., 2005, Meyer and Aberle, 2006, Srivastava et al., 2007, Miller et al., 2011, Xie and Auld, 2011, Miller et al., 2008, McClure et al., 2008, Gilchrist et al., 2008, Dominguez-Gimenez et al., 2007, Glasheen et al., 2009, Guha et al., 2009, Ostrin et al., 2006, Wang et al., 2010, Macdonald and Long, 2006, Yasunaga et al., 2010, Shen et al., 2009, Aerts et al., 2010, Schmidt et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Stevens and Page-McCaw, 2012, Nfonsam et al., 2012, Sui et al., 2012) mmp2 (Vidal et al., 2006, Uhlirova and Bohmann, 2006, Beaucher et al., 2007, Siekhaus et al., 2010, Schmidt et al., 2011)
Name Synonym	matrix metalloprotease 2 (Wang et al., 2010) Matrix metalloproteinase (Macdonald and Long, 2006) matrix metalloproteinase (Schmidt et al., 2011) Matrix metalloproteinase 2 (Page-McCaw et al., 2002, Shen et al., 2009)
Secondary FlyBase IDs
	FBgn0010512 FBgn0061593
References ( 74 )
Generate a list of	All references relating to this gene ( 74 )
List References by type	Research paper  ( 42 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 3 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Patent  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 8 )
	Pitsouli and Perrimon, 2013, Sci. Signal. 6(263): ra12 The homeobox transcription factor cut coordinates patterning and growth during Drosophila airway remodeling. [FBrf0220848] Nfonsam et al., 2012, PLoS ONE 7(8): e44583 Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414] Stevens and Page-McCaw, 2012, Mol. Biol. Cell 23(6): 1068--1079 A secreted MMP is required for reepithelialization during wound healing. [FBrf0217752] Sui et al., 2012, Development 139(15): 2773--2782 The Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc. [FBrf0218841] Bond et al., 2011, Dev. Biol. 360(2): 286--296 ßFTZ-F1 and Matrix metalloproteinase 2 are required for fat-body remodeling in Drosophila. [FBrf0216600] Miller et al., 2011, J. Neurosci. 31(14): 5335--5347 Drosophila mmp2 regulates the matrix molecule faulty attraction (frac) to promote motor axon targeting in Drosophila. [FBrf0213409] Schmidt et al., 2011, Self Nonself 2(3): 125--141 Cleavage of PGRP-LC receptor in the Drosophila IMD pathway in response to live bacterial infection in S2 cells. [FBrf0218028] Xie and Auld, 2011, Development 138(17): 3813--3822 Integrins are necessary for the development and maintenance of the glial layers in the Drosophila peripheral nerve. [FBrf0214589] Show all research papers ...
Recent reviews ( 2 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Meyer et al., 2011, Europ. J. Cell Biol. 90(9): 770--778 Drosophila metalloproteases in development and differentiation: The role of ADAM proteins and their relatives. [FBrf0214506] Show all reviews ...