• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\hebe

General Information
Symbol	Dmel\hebe	Species	D. melanogaster
Name	hebe	Annotation symbol	CG1623
Feature type	protein_coding_gene	FlyBase ID	FBgn0033448
Gene Model Status	Current	Stock availability	18 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	46B4-46B4	Sequence location	2R:5,715,609..5,724,147 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene hebe is referred to in FlyBase by the symbol Dmel\hebe (CG1623, FBgn0033448). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: determination of adult lifespan. 22 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, adult fat body, larval salivary gland, larval trachea, adult spermathecae, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636899_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of hebe. Gene sequence location is 2R:5715609..5724147.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 46B4-46B4   Limits computationally determined from genome sequence between P{lacW}l(2)k09221k09221&P{PZ}dap04454 and P{lacW}l(2)k05420k05420
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\hebe for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) hebe-RB FBtr0088486  NM_165699   1850   456 hebe-RD FBtr0088487  NM_165700   1956   456 hebe-RE FBtr0088490  NM_165701   1825   456 hebe-RF FBtr0113061  NM_001103778   1820   456
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein hebe-PB   FBpp0087570   48.5   456   4.30     NP_724828   AAM68796 hebe-PD   FBpp0087571   48.5   456   4.30     NP_724829   AAM68798 hebe-PE   FBpp0087574   48.5   456   4.30     NP_724830   AAM68799 hebe-PF   FBpp0111974   48.5   456   4.30     NP_001097248   AAM68797
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAM68796   AE013599 AAM68797   AE013599 AAM68798   AE013599 AAM68799   AI133874   AI135618   AI296731   AI389462   AI402221   AI517602   AY051431 AAK92855   BF497605   BF498335   BF506537   BI163135   BI166493   BI167027   BI168077   BI169804   BI171172   BI171392   BI172448   BI214155   BI230325   BI239699   BI240185   BI354076   BI356675   BI362411   BI363119   BI365182   BI369639   BI370695   BI373968   BI375827   CK657002   CO187554   CO196560   CO280093   CO299142   CO311438   EC091147   EC213685   EC233738   EC240977   ES688936   ES688958   ES689054   ES689148   ES689577   ES689589   ES689618   ES689669   ES689685   ES689689   ES693565   ES693652   ES694152   ES695288   GH759864   GH810446   GH869573   GH906108   GH908991   GH913368   GH915714   GH935546
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K568
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic antennal sense organ   (Fisher et al., 2012) embryonic/larval posterior spiracle   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) midline ventral glial cell   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, adult fat body, larval salivary gland, larval trachea, adult spermathecae, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    98.075 Larval Midgut    1075 Larval Hindgut    610.3 Larval Malpighian Tubules    509 Larval Fat Body    49.2 Larval Salivary Gland    393.3 Larval Trachea    177.4 Larval Carcass    124.55 Adult Head    178.6 Adult Eye    210.9 Adult Brain    50.3 Adult Thoracic-Abdominal Ganglion    109.1 Adult Crop    376.8 Adult Midgut    925.2 Adult Hindgut    714.7 Adult Malpighian Tubules    811.4 Adult Fat Body    101.4 Adult Salivary Gland    3772.4 Adult Heart    38.8 Adult VirginFemale Spermatheca    187.4 Adult InseminatedFemale Spermatheca    222.6 Adult Ovary    44.9 Adult Testis    44.6 Adult Male Accessory Gland    543.5 Adult Carcass    164.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    98.075 Larval Midgut  (1075) Larval Hindgut  (610.3) Larval Malpighian Tubules  509 Larval Fat Body    49.2 Larval Salivary Gland    393.3 Larval Trachea    177.4 Larval Carcass    124.55 Adult Head    178.6 Adult Eye    210.9 Adult Brain    50.3 Adult Thoracic-Abdominal Ganglion    109.1 Adult Crop    376.8 Adult Midgut  (925.2) Adult Hindgut  (714.7) Adult Malpighian Tubules  (811.4) Adult Fat Body    101.4 Adult Salivary Gland  (3772.4) Adult Heart    38.8 Adult VirginFemale Spermatheca    187.4 Adult InseminatedFemale Spermatheca    222.6 Adult Ovary    44.9 Adult Testis    44.6 Adult Male Accessory Gland  (543.5) Adult Carcass    164.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    98.075 Larval Midgut  1075 Larval Hindgut    610.3 Larval Malpighian Tubules    509 Larval Fat Body    49.2 Larval Salivary Gland    393.3 Larval Trachea    177.4 Larval Carcass    124.55 Adult Head    178.6 Adult Eye    210.9 Adult Brain    50.3 Adult Thoracic-Abdominal Ganglion    109.1 Adult Crop    376.8 Adult Midgut    925.2 Adult Hindgut    714.7 Adult Malpighian Tubules    811.4 Adult Fat Body    101.4 Adult Salivary Gland  (3772.4) Adult Heart    38.8 Adult VirginFemale Spermatheca    187.4 Adult InseminatedFemale Spermatheca    222.6 Adult Ovary    44.9 Adult Testis    44.6 Adult Male Accessory Gland    543.5 Adult Carcass    164.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    98.075 Larval Midgut    1075 Larval Hindgut    610.3 Larval Malpighian Tubules    509 Larval Fat Body    49.2 Larval Salivary Gland    393.3 Larval Trachea    177.4 Larval Carcass    124.55 Adult Head    178.6 Adult Eye    210.9 Adult Brain    50.3 Adult Thoracic-Abdominal Ganglion    109.1 Adult Crop    376.8 Adult Midgut    925.2 Adult Hindgut    714.7 Adult Malpighian Tubules    811.4 Adult Fat Body    101.4 Adult Salivary Gland    3772.4 Adult Heart    38.8 Adult VirginFemale Spermatheca    187.4 Adult InseminatedFemale Spermatheca    222.6 Adult Ovary    44.9 Adult Testis    44.6 Adult Male Accessory Gland    543.5 Adult Carcass    164.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    98.075 Larval Midgut    1075 Larval Hindgut    610.3 Larval Malpighian Tubules    509 Larval Fat Body    49.2 Larval Salivary Gland    393.3 Larval Trachea    177.4 Larval Carcass    124.55 Adult Head    178.6 Adult Eye    210.9 Adult Brain    50.3 Adult Thoracic-Abdominal Ganglion    109.1 Adult Crop    376.8 Adult Midgut    925.2 Adult Hindgut    714.7 Adult Malpighian Tubules    811.4 Adult Fat Body    101.4 Adult Salivary Gland    3772.4 Adult Heart    38.8 Adult VirginFemale Spermatheca    187.4 Adult InseminatedFemale Spermatheca    222.6 Adult Ovary    44.9 Adult Testis    44.6 Adult Male Accessory Gland    543.5 Adult Carcass    164.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    98.075 Larval Midgut  (1075) Larval Hindgut  610.3 Larval Malpighian Tubules  509 Larval Fat Body    49.2 Larval Salivary Gland    393.3 Larval Trachea    177.4 Larval Carcass    124.55 Adult Head    178.6 Adult Eye    210.9 Adult Brain    50.3 Adult Thoracic-Abdominal Ganglion    109.1 Adult Crop    376.8 Adult Midgut  (925.2) Adult Hindgut  714.7 Adult Malpighian Tubules  811.4 Adult Fat Body    101.4 Adult Salivary Gland  (3772.4) Adult Heart    38.8 Adult VirginFemale Spermatheca    187.4 Adult InseminatedFemale Spermatheca    222.6 Adult Ovary    44.9 Adult Testis    44.6 Adult Male Accessory Gland  543.5 Adult Carcass    164.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    98.075 Larval Midgut  1075 Larval Hindgut    610.3 Larval Malpighian Tubules    509 Larval Fat Body    49.2 Larval Salivary Gland    393.3 Larval Trachea    177.4 Larval Carcass    124.55 Adult Head    178.6 Adult Eye    210.9 Adult Brain    50.3 Adult Thoracic-Abdominal Ganglion    109.1 Adult Crop    376.8 Adult Midgut    925.2 Adult Hindgut    714.7 Adult Malpighian Tubules    811.4 Adult Fat Body    101.4 Adult Salivary Gland  (3772.4) Adult Heart    38.8 Adult VirginFemale Spermatheca    187.4 Adult InseminatedFemale Spermatheca    222.6 Adult Ovary    44.9 Adult Testis    44.6 Adult Male Accessory Gland    543.5 Adult Carcass    164.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    98.075 Larval Midgut    1075 Larval Hindgut    610.3 Larval Malpighian Tubules    509 Larval Fat Body    49.2 Larval Salivary Gland    393.3 Larval Trachea    177.4 Larval Carcass    124.55 Adult Head    178.6 Adult Eye    210.9 Adult Brain    50.3 Adult Thoracic-Abdominal Ganglion    109.1 Adult Crop    376.8 Adult Midgut    925.2 Adult Hindgut    714.7 Adult Malpighian Tubules    811.4 Adult Fat Body    101.4 Adult Salivary Gland    3772.4 Adult Heart    38.8 Adult VirginFemale Spermatheca    187.4 Adult InseminatedFemale Spermatheca    222.6 Adult Ovary    44.9 Adult Testis    44.6 Adult Male Accessory Gland    543.5 Adult Carcass    164.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    178.6   NA  Eye    210.9   NA  Brain    50.3   98.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    109.1   NA  Crop    376.8   1075  Midgut    925.2   610.3  Hindgut    714.7   509  Malpighian Tubules    811.4   49.2  Fat Body    101.4   393.3  Salivary Gland    3772.4   NA  Heart    38.8   177.4  Trachea    NA   NA  VirginFemale Spermatheca    187.4   NA  InseminatedFemale Spermatheca    222.6   NA  Ovary    44.9   NA  Testis    44.6   NA  Male Accessory Gland    543.5   124.55  Carcass    164.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female    29 head, virgin 4-day female    30 head, virgin 20-day female    25 head, mated 1-day female    29 head, mated 4-day female    21 head, mated 20-day female    21 head, mated 1-day male    50 head, mated 4-day male    40 head, mated 20-day male    44 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    71 digestive system, 1-day adult    231 digestive system, 4-day adult    180 digestive system, 20-day adult    189 fat body, larvae L3 wandering    10 fat body, white prepupae    2 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    34 carcass, 4-day adult    38 carcass, 20-day adult    45 ovary, virgin 4-day female    6 ovary, mated 4-day female    7 testis, mated 4-day male    24 accessory gland, mated 4-day male    117 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (30) central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female  (29) head, virgin 4-day female  (30) head, virgin 20-day female    25 head, mated 1-day female  (29) head, mated 4-day female    21 head, mated 20-day female    21 head, mated 1-day male  (50) head, mated 4-day male  (40) head, mated 20-day male  (44) salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    2 digestive system, larvae L3 wandering  (71) digestive system, 1-day adult  (231) digestive system, 4-day adult  (180) digestive system, 20-day adult  (189) fat body, larvae L3 wandering    10 fat body, white prepupae    2 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult  (34) carcass, 4-day adult  (38) carcass, 20-day adult  (45) ovary, virgin 4-day female    6 ovary, mated 4-day female    7 testis, mated 4-day male    24 accessory gland, mated 4-day male  (117) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female    29 head, virgin 4-day female    30 head, virgin 20-day female    25 head, mated 1-day female    29 head, mated 4-day female    21 head, mated 20-day female    21 head, mated 1-day male    50 head, mated 4-day male    40 head, mated 20-day male    44 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    71 digestive system, 1-day adult  (231) digestive system, 4-day adult  (180) digestive system, 20-day adult  (189) fat body, larvae L3 wandering    10 fat body, white prepupae    2 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    34 carcass, 4-day adult    38 carcass, 20-day adult    45 ovary, virgin 4-day female    6 ovary, mated 4-day female    7 testis, mated 4-day male    24 accessory gland, mated 4-day male  (117) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female    29 head, virgin 4-day female    30 head, virgin 20-day female    25 head, mated 1-day female    29 head, mated 4-day female    21 head, mated 20-day female    21 head, mated 1-day male    50 head, mated 4-day male    40 head, mated 20-day male    44 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    71 digestive system, 1-day adult    231 digestive system, 4-day adult    180 digestive system, 20-day adult    189 fat body, larvae L3 wandering    10 fat body, white prepupae    2 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    34 carcass, 4-day adult    38 carcass, 20-day adult    45 ovary, virgin 4-day female    6 ovary, mated 4-day female    7 testis, mated 4-day male    24 accessory gland, mated 4-day male    117 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female    29 head, virgin 4-day female    30 head, virgin 20-day female    25 head, mated 1-day female    29 head, mated 4-day female    21 head, mated 20-day female    21 head, mated 1-day male    50 head, mated 4-day male    40 head, mated 20-day male    44 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    71 digestive system, 1-day adult    231 digestive system, 4-day adult    180 digestive system, 20-day adult    189 fat body, larvae L3 wandering    10 fat body, white prepupae    2 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    34 carcass, 4-day adult    38 carcass, 20-day adult    45 ovary, virgin 4-day female    6 ovary, mated 4-day female    7 testis, mated 4-day male    24 accessory gland, mated 4-day male    117 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  30 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female  29 head, virgin 4-day female  30 head, virgin 20-day female    25 head, mated 1-day female  29 head, mated 4-day female    21 head, mated 20-day female    21 head, mated 1-day male  (50) head, mated 4-day male  (40) head, mated 20-day male  (44) salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    2 digestive system, larvae L3 wandering  (71) digestive system, 1-day adult  (231) digestive system, 4-day adult  (180) digestive system, 20-day adult  (189) fat body, larvae L3 wandering    10 fat body, white prepupae    2 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult  (34) carcass, 4-day adult  (38) carcass, 20-day adult  (45) ovary, virgin 4-day female    6 ovary, mated 4-day female    7 testis, mated 4-day male    24 accessory gland, mated 4-day male  (117) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female    29 head, virgin 4-day female    30 head, virgin 20-day female    25 head, mated 1-day female    29 head, mated 4-day female    21 head, mated 20-day female    21 head, mated 1-day male    50 head, mated 4-day male    40 head, mated 20-day male    44 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    71 digestive system, 1-day adult  (231) digestive system, 4-day adult  (180) digestive system, 20-day adult  (189) fat body, larvae L3 wandering    10 fat body, white prepupae    2 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    34 carcass, 4-day adult    38 carcass, 20-day adult    45 ovary, virgin 4-day female    6 ovary, mated 4-day female    7 testis, mated 4-day male    24 accessory gland, mated 4-day male  117 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    12 central nervous system, pupae P8    4 head, virgin 1-day female    29 head, virgin 4-day female    30 head, virgin 20-day female    25 head, mated 1-day female    29 head, mated 4-day female    21 head, mated 20-day female    21 head, mated 1-day male    50 head, mated 4-day male    40 head, mated 20-day male    44 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    71 digestive system, 1-day adult    231 digestive system, 4-day adult    180 digestive system, 20-day adult    189 fat body, larvae L3 wandering    10 fat body, white prepupae    2 fat body, pupae P8    16 carcass, larvae L3 wandering    17 carcass, 1-day adult    34 carcass, 4-day adult    38 carcass, 20-day adult    45 ovary, virgin 4-day female    6 ovary, mated 4-day female    7 testis, mated 4-day male    24 accessory gland, mated 4-day male    117 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    11 embryo 14-16hr    35 embryo 16-18hr    54 embryo 18-20hr    112 embryo 20-22hr    170 embryo 22-24hr    141 larva L1    78 larva L2    111 larva L3 12hr old    67 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    8 white prepupae new    2 white prepupae 12hr    12 white prepupae 24hr    6 pupae 2d postWPP    30 pupae 3d postWPP    7 pupae 4d postWPP    51 adult male 01day    40 adult male 05day    49 adult male 30day    41 adult female 01day    37 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    11 embryo 14-16hr  (35) embryo 16-18hr  (54) embryo 18-20hr  (112) embryo 20-22hr  (170) embryo 22-24hr  (141) larva L1  (78) larva L2  (111) larva L3 12hr old  (67) larva L3 puffstage 1-2  (45) larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    8 white prepupae new    2 white prepupae 12hr    12 white prepupae 24hr    6 pupae 2d postWPP  (30) pupae 3d postWPP    7 pupae 4d postWPP  (51) adult male 01day  (40) adult male 05day  (49) adult male 30day  (41) adult female 01day  (37) adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    11 embryo 14-16hr    35 embryo 16-18hr    54 embryo 18-20hr  (112) embryo 20-22hr  (170) embryo 22-24hr  (141) larva L1    78 larva L2  (111) larva L3 12hr old    67 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    8 white prepupae new    2 white prepupae 12hr    12 white prepupae 24hr    6 pupae 2d postWPP    30 pupae 3d postWPP    7 pupae 4d postWPP    51 adult male 01day    40 adult male 05day    49 adult male 30day    41 adult female 01day    37 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    11 embryo 14-16hr    35 embryo 16-18hr    54 embryo 18-20hr    112 embryo 20-22hr    170 embryo 22-24hr    141 larva L1    78 larva L2    111 larva L3 12hr old    67 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    8 white prepupae new    2 white prepupae 12hr    12 white prepupae 24hr    6 pupae 2d postWPP    30 pupae 3d postWPP    7 pupae 4d postWPP    51 adult male 01day    40 adult male 05day    49 adult male 30day    41 adult female 01day    37 adult female 05day    24 adult female 30day    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    11 embryo 14-16hr    35 embryo 16-18hr    54 embryo 18-20hr    112 embryo 20-22hr    170 embryo 22-24hr    141 larva L1    78 larva L2    111 larva L3 12hr old    67 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    8 white prepupae new    2 white prepupae 12hr    12 white prepupae 24hr    6 pupae 2d postWPP    30 pupae 3d postWPP    7 pupae 4d postWPP    51 adult male 01day    40 adult male 05day    49 adult male 30day    41 adult female 01day    37 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    11 embryo 14-16hr  (35) embryo 16-18hr  (54) embryo 18-20hr  (112) embryo 20-22hr  (170) embryo 22-24hr  (141) larva L1  (78) larva L2  (111) larva L3 12hr old  (67) larva L3 puffstage 1-2  (45) larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    8 white prepupae new    2 white prepupae 12hr    12 white prepupae 24hr    6 pupae 2d postWPP  30 pupae 3d postWPP    7 pupae 4d postWPP  (51) adult male 01day  (40) adult male 05day  (49) adult male 30day  (41) adult female 01day  (37) adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    11 embryo 14-16hr    35 embryo 16-18hr    54 embryo 18-20hr  112 embryo 20-22hr  (170) embryo 22-24hr  141 larva L1    78 larva L2  111 larva L3 12hr old    67 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    8 white prepupae new    2 white prepupae 12hr    12 white prepupae 24hr    6 pupae 2d postWPP    30 pupae 3d postWPP    7 pupae 4d postWPP    51 adult male 01day    40 adult male 05day    49 adult male 30day    41 adult female 01day    37 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    11 embryo 14-16hr    35 embryo 16-18hr    54 embryo 18-20hr    112 embryo 20-22hr    170 embryo 22-24hr    141 larva L1    78 larva L2    111 larva L3 12hr old    67 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    8 white prepupae new    2 white prepupae 12hr    12 white prepupae 24hr    6 pupae 2d postWPP    30 pupae 3d postWPP    7 pupae 4d postWPP    51 adult male 01day    40 adult male 05day    49 adult male 30day    41 adult female 01day    37 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    5 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    3 embryonic S1    19 embryonic S3    0 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    5 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    3 embryonic S1    19 embryonic S3    0 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    5 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    3 embryonic S1    19 embryonic S3    0 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    5 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    3 embryonic S1    19 embryonic S3    0 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    5 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    3 embryonic S1    19 embryonic S3    0 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    5 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    3 embryonic S1    19 embryonic S3    0 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    5 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    3 embryonic S1    19 embryonic S3    0 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    5 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    3 embryonic S1    19 embryonic S3    0 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    5 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    29 cold shock, 4-day adult    21 heat shock, 4-day adult    61 Cadmium 50 mM 6 hrs, larvae L3    103 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    107 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    90 Zinc 4.5 mM 48 hrs, 4-day adult    45 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    113 Ethanol 10% 3 hrs, larvae L3    95 Caffeine 1.5 mg/ml 4 hrs, larvae L3    58 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    67 Rotenone 2 μg 12 hrs, larvae L3    87 Rotenone 8 μg 12 hrs, larvae L3    135 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (29) cold shock, 4-day adult    21 heat shock, 4-day adult  (61) Cadmium 50 mM 6 hrs, larvae L3  (103) Cadmium 50 mM 12 hrs, larvae L3  (37) Cadmium 50 mM 48 hrs, 4-day adult  (78) Cadmium 100 mM 48 hrs, 4-day adult  (31) Copper 0.5 mM 12 hrs, larvae L3  (107) Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3  (90) Zinc 4.5 mM 48 hrs, 4-day adult  (45) Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3  (113) Ethanol 10% 3 hrs, larvae L3  (95) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (58) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult  (27) Paraquat 5 mM 48 hrs, 4-day adult  (52) Paraquat 10 mM 48 hrs, 4-day adult  (67) Rotenone 2 μg 12 hrs, larvae L3  (87) Rotenone 8 μg 12 hrs, larvae L3  (135) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    29 cold shock, 4-day adult    21 heat shock, 4-day adult    61 Cadmium 50 mM 6 hrs, larvae L3  103 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3  107 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    90 Zinc 4.5 mM 48 hrs, 4-day adult    45 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3  (113) Ethanol 10% 3 hrs, larvae L3    95 Caffeine 1.5 mg/ml 4 hrs, larvae L3    58 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    67 Rotenone 2 μg 12 hrs, larvae L3    87 Rotenone 8 μg 12 hrs, larvae L3  (135) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    29 cold shock, 4-day adult    21 heat shock, 4-day adult    61 Cadmium 50 mM 6 hrs, larvae L3    103 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    107 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    90 Zinc 4.5 mM 48 hrs, 4-day adult    45 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    113 Ethanol 10% 3 hrs, larvae L3    95 Caffeine 1.5 mg/ml 4 hrs, larvae L3    58 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    67 Rotenone 2 μg 12 hrs, larvae L3    87 Rotenone 8 μg 12 hrs, larvae L3    135 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    29 cold shock, 4-day adult    21 heat shock, 4-day adult    61 Cadmium 50 mM 6 hrs, larvae L3    103 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    107 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    90 Zinc 4.5 mM 48 hrs, 4-day adult    45 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    113 Ethanol 10% 3 hrs, larvae L3    95 Caffeine 1.5 mg/ml 4 hrs, larvae L3    58 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    67 Rotenone 2 μg 12 hrs, larvae L3    87 Rotenone 8 μg 12 hrs, larvae L3    135 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  29 cold shock, 4-day adult    21 heat shock, 4-day adult  (61) Cadmium 50 mM 6 hrs, larvae L3  (103) Cadmium 50 mM 12 hrs, larvae L3  (37) Cadmium 50 mM 48 hrs, 4-day adult  (78) Cadmium 100 mM 48 hrs, 4-day adult  31 Copper 0.5 mM 12 hrs, larvae L3  (107) Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3  (90) Zinc 4.5 mM 48 hrs, 4-day adult  (45) Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3  (113) Ethanol 10% 3 hrs, larvae L3  (95) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (58) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult  27 Paraquat 5 mM 48 hrs, 4-day adult  (52) Paraquat 10 mM 48 hrs, 4-day adult  (67) Rotenone 2 μg 12 hrs, larvae L3  (87) Rotenone 8 μg 12 hrs, larvae L3  (135) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    29 cold shock, 4-day adult    21 heat shock, 4-day adult    61 Cadmium 50 mM 6 hrs, larvae L3  103 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3  107 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    90 Zinc 4.5 mM 48 hrs, 4-day adult    45 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3  113 Ethanol 10% 3 hrs, larvae L3    95 Caffeine 1.5 mg/ml 4 hrs, larvae L3    58 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    67 Rotenone 2 μg 12 hrs, larvae L3    87 Rotenone 8 μg 12 hrs, larvae L3  135 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    29 cold shock, 4-day adult    21 heat shock, 4-day adult    61 Cadmium 50 mM 6 hrs, larvae L3    103 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    107 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    90 Zinc 4.5 mM 48 hrs, 4-day adult    45 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    113 Ethanol 10% 3 hrs, larvae L3    95 Caffeine 1.5 mg/ml 4 hrs, larvae L3    58 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    67 Rotenone 2 μg 12 hrs, larvae L3    87 Rotenone 8 μg 12 hrs, larvae L3    135 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_20 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • GH10642 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033448 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1623-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 hebeGD9166 Other Phenotypes Allele long lived hebePdL hebeTn10\tetO.cLa long lived, with Scer\GAL4D42, Tn10\tetRM2.alt.Scer\UAS.T:Hsim\VP16 hebeTn10\tetO.cLa Phenotype manifest in Allele
Classical Alleles ( 18 )
For All Classical Alleles Show
Allele of hebe Class Mutagen Stocks Known lesion hebe5-SZ-3555 1 -- hebe5-SZ-3984 1 -- hebec00567 1 -- hebeCB-5273-3 1 -- hebeCB-6280-3 1 -- hebeKG00192 1 -- hebeMB00136 1 -- hebeMI06665 1 -- hebeNP0804 1 -- hebeNP0964 1 -- hebeNP1204 1 -- hebeNP3272 1 -- hebeNP6246 1 -- hebeNP6263 1 -- hebeSH2065 1 -- hebeBG01510 P-element activity 0 -- hebeEP2603 0 -- hebePdL 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of hebe Class Mutagen Stocks Known lesion hebeGD9166 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes hebeKK110084 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hebeNIG.1623R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes hebeTn10\tetO.cLa in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.1623R} NA characterization construct P{tetO-hebe.L} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}hebeMI06665 NA P{GT1}hebeBG01510 NA P{RS3}hebeCB-5273-3 NA P{RS3}hebeCB-6280-3 NA P{RS5}hebe5-SZ-3555 NA P{RS5}hebe5-SZ-3984 NA P{SUPor-P}hebeKG00192 NA PBac{PB}hebec00567 NA insertion of mobile activating element P{EP}hebeEP2603 NA P{PdL}hebe NA insertion of enhancer trap P{lacW}hebeSH2065 No insertion of enhancer trap binary system Mi{ET1}hebeMB00136 No P{GawB}21.2821.28 No P{GawB}hebeNP0804 No P{GawB}hebeNP0964 No P{GawB}hebeNP1204 No P{GawB}hebeNP3272 No P{GawB}hebeNP6246 No P{GawB}hebeNP6263 No
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
determination of adult lifespan inferred from mutant phenotype (Li and Tower, 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
hebe - Arf79F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hebe - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hebe - Cyp6a17 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hebe - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hebe - Tango7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hebe - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hebe - eIF4AIII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions hebe allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033448 DroID - A comprehensive database of gene and protein interactions. • FBgn0033448
Orthologs
OrthoDB Orthologs (9) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6NP7PP Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6NP7PP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\hebe     Drosophila sechellia   Dsec\GM20577 Y   Drosophila erecta   Dere\GG25259 Y   Drosophila yakuba   Dyak\GE22039 Y   Drosophila ananassae   Dana\GF11476 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14053 Y   Drosophila persimilis   Dper\GL17394 Y   Drosophila willistoni   Dwil\GK15612 Y   Drosophila grimshawi   Dgri\GH22845 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM20577 Drosophila erecta Dere\GG25259 Drosophila yakuba Dyak\GE22039 Drosophila ananassae Dana\GF11476 Drosophila pseudoobscura pseudoobscura Dpse\GA14053 Drosophila persimilis Dper\GL17394 Drosophila willistoni Dwil\GK15612 Drosophila virilis Dvir\GJ20827 Drosophila mojavensis Dmoj\GI21223 Drosophila grimshawi Dgri\GH22845
Stocks & Reagents
Stocks Listed in FlyBase ( 18 )
Bloomington	42418 y1 w*; Mi{MIC}hebeMI06665 22709 y1 w67c23; Mi{ET1}hebeMB00136 13058 y1 w67c23; P{SUPor-P}hebeKG00192
Harvard	- PBac{PB}hebec00567
Kyoto	123541 w1118; P{RS3}hebeCB-5273-3 124018 w1118; P{RS3}hebeCB-6280-3 126128 w1118; P{RS5}hebe5-SZ-3555 126270 w1118; P{RS5}hebe5-SZ-3984 112340 w*; P{GawB}hebeNP0804 / CyO; TM3, Ser1
VDRC	v107655 P{KK110084}VIE-260B v32665 w1118; P{GD9166}v32665/CyO v32666 w1118; P{GD9166}v32666/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR01L01 BACR30G11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 49 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10642
Other clones	DPiM_GH10642
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09043 AT11813 AT12729 GH13439 GH20641 GH28627 GM26184 LP10778 LP22911 RE02463 RE06637 RE07301 RE08619 RE10117 RE11082 RE12872 RE13150 RE14941 RE19873 RE36268 RE36872 RE42866 RE46959 RE47854 RE50421 RE55883 RE57416 RE61455 RE63709
Other clones	39152 102889 CK01.35C.C6 CK01.117B.A12 EK005727 EK030333 EK152449 EK174624 EK224551 RC0-DL0001-140700-026-A11 RP003102275 RP003106227 RP003147334 RP003210153 RP003239276 RP003246240 RP003327529 RP003548714
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033448 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36011
Antibody Information
Other Information
Discoverer
Etymology
	Named 'hebe' after an immortal deity from Greek mythology. (Li and Tower, 2009)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: hebe CG1623 (Li and Tower, 2009)
Source for database merge of
Additional comments
Other Comments
	Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene. (Hansen et al., 2009) Overexpression of hebe preferentially in adult motor-neurons increases female life span. (Li and Tower, 2009) Ubiquitous overexpression of hebe in adult females modulates fecundity. (Li and Tower, 2009)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165699 NM_165700 NM_165701 NM_001103778 RefSeq (Proteins) • NP_724828 NP_724829 NP_724830 NP_001097248 DDBJ / EMBL / GenBank • AAK92855 AAM68796 AAM68797 AAM68798 AAM68799 AI133874 AI402221 AY051431 Entrez Gene - A searchable database of RefSeq genes. • 36011 UniProtKB/TrEMBL • Q7K568
Other Crossreferences
	BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH10642
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033448 DroID - A comprehensive database of gene and protein interactions. • FBgn0033448 DRSC - Results from RNAi screens. • FBgn0033448 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033448 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1623-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033448 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36011 modMine - Data generated by the modENCODE project. • FBgn0033448
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG1623 (Li and Tower, 2009, Edwards et al., 2006, Robin et al., 2007, Hansen et al., 2009, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21) hebe (Levis et al., 2011.12.16, Eddison et al., 2012)
Name Synonym	hebe (Li and Tower, 2009)
Secondary FlyBase IDs
References ( 23 )
Generate a list of	All references relating to this gene ( 23 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 )
Recent research papers ( 2 )
	Eddison et al., 2012, PLoS ONE 7(12): e51684 A genetic screen for olfactory habituation mutations in Drosophila: analysis of novel foraging alleles and an underlying neural circuit. [FBrf0220425] Dottorini et al., 2011, BMC Bioinformatics 12: 34 Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...