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Gene Dmel\Etf-QO

General Information
Symbol	Dmel\Etf-QO	Species	D. melanogaster
Name	Electron transfer flavoprotein-ubiquinone oxidoreductase	Annotation symbol	CG12140
Feature type	protein_coding_gene	FlyBase ID	FBgn0033465
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	46C4-46C4	Sequence location	2R:5,798,398..5,800,993 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Electron transfer flavoprotein-ubiquinone oxidoreductase is referred to in FlyBase by the symbol Dmel\Etf-QO (CG12140, FBgn0033465). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: electron-transferring-flavoprotein dehydrogenase activity. There is experimental evidence that it is involved in the biological process: fatty acid beta-oxidation. 8 alleles are reported. The phenotype of these alleles is annotated with: embryonic/larval cuticle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Electron transfer flavoprotein-ubiquinone oxidoreductase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1628777_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG12140. Gene sequence location is 2R:5798398..5800993.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 46C4-46C4   Limits computationally determined from genome sequence between P{lacW}l(2)k07803k07803&P{lacW}l(2)k08816k08816 and P{lacW}l(2)k08601k08601
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Etf-QO for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Etf-QO-RA FBtr0088384  NM_136692   2300   604 Etf-QO-RB FBtr0308338  NM_001259302   2243   604
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Etf-QO-PA   FBpp0087472   66.0   604   6.63     NP_610536   AAF58873 Etf-QO-PB   FBpp0300657   66.0   604   6.63     NP_001246231   AFH07986
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Electron transfer flavoprotein-ubiquinone oxidoreductase (IPR007859) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME12140
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA438623   AA820739   AE013599 AAF58873   AE013599 AFH07986   AI108012   AY113586 AAM29591   BF499037   BI163669   BI165200   BI173622   BI227989   BI367081   BI368244   BI615740   BI634704   CK660882   CO265369   CO282923   CO294249   CO312584   CO331209   CZ483940   CZ488252   EC088790   EC201442   EC234089   EC248350   EL873952   EV580396   EV581723   EV585456   EV599715   GH740305   GH741380   GH742802   GH744113   GH744359   GH747053   GH768612   GH779712
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JWF1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008) mitochondrion inferred from direct assay (Alonso et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    113.975 Larval Midgut    310.3 Larval Hindgut    352.6 Larval Malpighian Tubules    193 Larval Fat Body    547.9 Larval Salivary Gland    358.5 Larval Trachea    199.725 Larval Carcass    275.375 Adult Head    455.9 Adult Eye    193.025 Adult Brain    102.3 Adult Thoracic-Abdominal Ganglion    97.3 Adult Crop    633.9 Adult Midgut    320.5 Adult Hindgut    402.3 Adult Malpighian Tubules    524.3 Adult Fat Body    1385.8 Adult Salivary Gland    175.7 Adult Heart    690.975 Adult VirginFemale Spermatheca    1183.6 Adult InseminatedFemale Spermatheca    1002.9 Adult Ovary    238.4 Adult Testis    21.1 Adult Male Accessory Gland    124.5 Adult Carcass    861.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    113.975 Larval Midgut    310.3 Larval Hindgut    352.6 Larval Malpighian Tubules    193 Larval Fat Body  (547.9) Larval Salivary Gland    358.5 Larval Trachea    199.725 Larval Carcass    275.375 Adult Head    455.9 Adult Eye    193.025 Adult Brain    102.3 Adult Thoracic-Abdominal Ganglion    97.3 Adult Crop  (633.9) Adult Midgut    320.5 Adult Hindgut    402.3 Adult Malpighian Tubules  524.3 Adult Fat Body  (1385.8) Adult Salivary Gland    175.7 Adult Heart  (690.975) Adult VirginFemale Spermatheca  (1183.6) Adult InseminatedFemale Spermatheca  (1002.9) Adult Ovary    238.4 Adult Testis    21.1 Adult Male Accessory Gland    124.5 Adult Carcass  (861.6) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    113.975 Larval Midgut    310.3 Larval Hindgut    352.6 Larval Malpighian Tubules    193 Larval Fat Body    547.9 Larval Salivary Gland    358.5 Larval Trachea    199.725 Larval Carcass    275.375 Adult Head    455.9 Adult Eye    193.025 Adult Brain    102.3 Adult Thoracic-Abdominal Ganglion    97.3 Adult Crop    633.9 Adult Midgut    320.5 Adult Hindgut    402.3 Adult Malpighian Tubules    524.3 Adult Fat Body  (1385.8) Adult Salivary Gland    175.7 Adult Heart    690.975 Adult VirginFemale Spermatheca  (1183.6) Adult InseminatedFemale Spermatheca  1002.9 Adult Ovary    238.4 Adult Testis    21.1 Adult Male Accessory Gland    124.5 Adult Carcass    861.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    113.975 Larval Midgut    310.3 Larval Hindgut    352.6 Larval Malpighian Tubules    193 Larval Fat Body    547.9 Larval Salivary Gland    358.5 Larval Trachea    199.725 Larval Carcass    275.375 Adult Head    455.9 Adult Eye    193.025 Adult Brain    102.3 Adult Thoracic-Abdominal Ganglion    97.3 Adult Crop    633.9 Adult Midgut    320.5 Adult Hindgut    402.3 Adult Malpighian Tubules    524.3 Adult Fat Body    1385.8 Adult Salivary Gland    175.7 Adult Heart    690.975 Adult VirginFemale Spermatheca    1183.6 Adult InseminatedFemale Spermatheca    1002.9 Adult Ovary    238.4 Adult Testis    21.1 Adult Male Accessory Gland    124.5 Adult Carcass    861.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    113.975 Larval Midgut    310.3 Larval Hindgut    352.6 Larval Malpighian Tubules    193 Larval Fat Body    547.9 Larval Salivary Gland    358.5 Larval Trachea    199.725 Larval Carcass    275.375 Adult Head    455.9 Adult Eye    193.025 Adult Brain    102.3 Adult Thoracic-Abdominal Ganglion    97.3 Adult Crop    633.9 Adult Midgut    320.5 Adult Hindgut    402.3 Adult Malpighian Tubules    524.3 Adult Fat Body    1385.8 Adult Salivary Gland    175.7 Adult Heart    690.975 Adult VirginFemale Spermatheca    1183.6 Adult InseminatedFemale Spermatheca    1002.9 Adult Ovary    238.4 Adult Testis    21.1 Adult Male Accessory Gland    124.5 Adult Carcass    861.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    113.975 Larval Midgut    310.3 Larval Hindgut    352.6 Larval Malpighian Tubules    193 Larval Fat Body  547.9 Larval Salivary Gland    358.5 Larval Trachea    199.725 Larval Carcass    275.375 Adult Head    455.9 Adult Eye    193.025 Adult Brain    102.3 Adult Thoracic-Abdominal Ganglion    97.3 Adult Crop  633.9 Adult Midgut    320.5 Adult Hindgut    402.3 Adult Malpighian Tubules  524.3 Adult Fat Body  (1385.8) Adult Salivary Gland    175.7 Adult Heart  690.975 Adult VirginFemale Spermatheca  (1183.6) Adult InseminatedFemale Spermatheca  (1002.9) Adult Ovary    238.4 Adult Testis    21.1 Adult Male Accessory Gland    124.5 Adult Carcass  (861.6) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    113.975 Larval Midgut    310.3 Larval Hindgut    352.6 Larval Malpighian Tubules    193 Larval Fat Body    547.9 Larval Salivary Gland    358.5 Larval Trachea    199.725 Larval Carcass    275.375 Adult Head    455.9 Adult Eye    193.025 Adult Brain    102.3 Adult Thoracic-Abdominal Ganglion    97.3 Adult Crop    633.9 Adult Midgut    320.5 Adult Hindgut    402.3 Adult Malpighian Tubules    524.3 Adult Fat Body  1385.8 Adult Salivary Gland    175.7 Adult Heart    690.975 Adult VirginFemale Spermatheca  1183.6 Adult InseminatedFemale Spermatheca  1002.9 Adult Ovary    238.4 Adult Testis    21.1 Adult Male Accessory Gland    124.5 Adult Carcass    861.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    113.975 Larval Midgut    310.3 Larval Hindgut    352.6 Larval Malpighian Tubules    193 Larval Fat Body    547.9 Larval Salivary Gland    358.5 Larval Trachea    199.725 Larval Carcass    275.375 Adult Head    455.9 Adult Eye    193.025 Adult Brain    102.3 Adult Thoracic-Abdominal Ganglion    97.3 Adult Crop    633.9 Adult Midgut    320.5 Adult Hindgut    402.3 Adult Malpighian Tubules    524.3 Adult Fat Body    1385.8 Adult Salivary Gland    175.7 Adult Heart    690.975 Adult VirginFemale Spermatheca    1183.6 Adult InseminatedFemale Spermatheca    1002.9 Adult Ovary    238.4 Adult Testis    21.1 Adult Male Accessory Gland    124.5 Adult Carcass    861.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    455.9   NA  Eye    193.025   NA  Brain    102.3   113.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    97.3   NA  Crop    633.9   310.3  Midgut    320.5   352.6  Hindgut    402.3   193  Malpighian Tubules    524.3   547.9  Fat Body    1385.8   358.5  Salivary Gland    175.7   NA  Heart    690.975   199.725  Trachea    NA   NA  VirginFemale Spermatheca    1183.6   NA  InseminatedFemale Spermatheca    1002.9   NA  Ovary    238.4   NA  Testis    21.1   NA  Male Accessory Gland    124.5   275.375  Carcass    861.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    14 central nervous system, pupae P8    11 head, virgin 1-day female    43 head, virgin 4-day female    29 head, virgin 20-day female    48 head, mated 1-day female    27 head, mated 4-day female    35 head, mated 20-day female    40 head, mated 1-day male    47 head, mated 4-day male    36 head, mated 20-day male    48 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    50 digestive system, 4-day adult    35 digestive system, 20-day adult    38 fat body, larvae L3 wandering    51 fat body, white prepupae    27 fat body, pupae P8    23 carcass, larvae L3 wandering    24 carcass, 1-day adult    46 carcass, 4-day adult    38 carcass, 20-day adult    46 ovary, virgin 4-day female    47 ovary, mated 4-day female    39 testis, mated 4-day male    9 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    14 central nervous system, pupae P8    11 head, virgin 1-day female  (43) head, virgin 4-day female  (29) head, virgin 20-day female  (48) head, mated 1-day female  (27) head, mated 4-day female  (35) head, mated 20-day female  (40) head, mated 1-day male  (47) head, mated 4-day male  (36) head, mated 20-day male  (48) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    13 digestive system, larvae L3 wandering  (31) digestive system, 1-day adult  (50) digestive system, 4-day adult  (35) digestive system, 20-day adult  (38) fat body, larvae L3 wandering  (51) fat body, white prepupae  (27) fat body, pupae P8    23 carcass, larvae L3 wandering    24 carcass, 1-day adult  (46) carcass, 4-day adult  (38) carcass, 20-day adult  (46) ovary, virgin 4-day female  (47) ovary, mated 4-day female  (39) testis, mated 4-day male    9 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    14 central nervous system, pupae P8    11 head, virgin 1-day female    43 head, virgin 4-day female    29 head, virgin 20-day female    48 head, mated 1-day female    27 head, mated 4-day female    35 head, mated 20-day female    40 head, mated 1-day male    47 head, mated 4-day male    36 head, mated 20-day male    48 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    50 digestive system, 4-day adult    35 digestive system, 20-day adult    38 fat body, larvae L3 wandering    51 fat body, white prepupae    27 fat body, pupae P8    23 carcass, larvae L3 wandering    24 carcass, 1-day adult    46 carcass, 4-day adult    38 carcass, 20-day adult    46 ovary, virgin 4-day female    47 ovary, mated 4-day female    39 testis, mated 4-day male    9 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    14 central nervous system, pupae P8    11 head, virgin 1-day female    43 head, virgin 4-day female    29 head, virgin 20-day female    48 head, mated 1-day female    27 head, mated 4-day female    35 head, mated 20-day female    40 head, mated 1-day male    47 head, mated 4-day male    36 head, mated 20-day male    48 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    50 digestive system, 4-day adult    35 digestive system, 20-day adult    38 fat body, larvae L3 wandering    51 fat body, white prepupae    27 fat body, pupae P8    23 carcass, larvae L3 wandering    24 carcass, 1-day adult    46 carcass, 4-day adult    38 carcass, 20-day adult    46 ovary, virgin 4-day female    47 ovary, mated 4-day female    39 testis, mated 4-day male    9 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    14 central nervous system, pupae P8    11 head, virgin 1-day female    43 head, virgin 4-day female    29 head, virgin 20-day female    48 head, mated 1-day female    27 head, mated 4-day female    35 head, mated 20-day female    40 head, mated 1-day male    47 head, mated 4-day male    36 head, mated 20-day male    48 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    50 digestive system, 4-day adult    35 digestive system, 20-day adult    38 fat body, larvae L3 wandering    51 fat body, white prepupae    27 fat body, pupae P8    23 carcass, larvae L3 wandering    24 carcass, 1-day adult    46 carcass, 4-day adult    38 carcass, 20-day adult    46 ovary, virgin 4-day female    47 ovary, mated 4-day female    39 testis, mated 4-day male    9 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    14 central nervous system, pupae P8    11 head, virgin 1-day female  (43) head, virgin 4-day female  29 head, virgin 20-day female  (48) head, mated 1-day female  27 head, mated 4-day female  (35) head, mated 20-day female  (40) head, mated 1-day male  (47) head, mated 4-day male  (36) head, mated 20-day male  (48) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    13 digestive system, larvae L3 wandering  31 digestive system, 1-day adult  (50) digestive system, 4-day adult  (35) digestive system, 20-day adult  (38) fat body, larvae L3 wandering  (51) fat body, white prepupae  27 fat body, pupae P8    23 carcass, larvae L3 wandering    24 carcass, 1-day adult  (46) carcass, 4-day adult  (38) carcass, 20-day adult  (46) ovary, virgin 4-day female  (47) ovary, mated 4-day female  (39) testis, mated 4-day male    9 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    14 central nervous system, pupae P8    11 head, virgin 1-day female    43 head, virgin 4-day female    29 head, virgin 20-day female    48 head, mated 1-day female    27 head, mated 4-day female    35 head, mated 20-day female    40 head, mated 1-day male    47 head, mated 4-day male    36 head, mated 20-day male    48 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    50 digestive system, 4-day adult    35 digestive system, 20-day adult    38 fat body, larvae L3 wandering    51 fat body, white prepupae    27 fat body, pupae P8    23 carcass, larvae L3 wandering    24 carcass, 1-day adult    46 carcass, 4-day adult    38 carcass, 20-day adult    46 ovary, virgin 4-day female    47 ovary, mated 4-day female    39 testis, mated 4-day male    9 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    14 central nervous system, pupae P8    11 head, virgin 1-day female    43 head, virgin 4-day female    29 head, virgin 20-day female    48 head, mated 1-day female    27 head, mated 4-day female    35 head, mated 20-day female    40 head, mated 1-day male    47 head, mated 4-day male    36 head, mated 20-day male    48 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    50 digestive system, 4-day adult    35 digestive system, 20-day adult    38 fat body, larvae L3 wandering    51 fat body, white prepupae    27 fat body, pupae P8    23 carcass, larvae L3 wandering    24 carcass, 1-day adult    46 carcass, 4-day adult    38 carcass, 20-day adult    46 ovary, virgin 4-day female    47 ovary, mated 4-day female    39 testis, mated 4-day male    9 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    19 embryo 04-06hr    5 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    22 embryo 12-14hr    21 embryo 14-16hr    26 embryo 16-18hr    25 embryo 18-20hr    28 embryo 20-22hr    26 embryo 22-24hr    30 larva L1    41 larva L2    62 larva L3 12hr old    65 larva L3 puffstage 1-2    43 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    26 white prepupae new    29 white prepupae 12hr    23 white prepupae 24hr    26 pupae 2d postWPP    28 pupae 3d postWPP    27 pupae 4d postWPP    23 adult male 01day    51 adult male 05day    46 adult male 30day    39 adult female 01day    44 adult female 05day    50 adult female 30day    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52) embryo 02-04hr    19 embryo 04-06hr    5 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    22 embryo 12-14hr    21 embryo 14-16hr  26 embryo 16-18hr    25 embryo 18-20hr  (28) embryo 20-22hr  26 embryo 22-24hr  (30) larva L1  (41) larva L2  (62) larva L3 12hr old  (65) larva L3 puffstage 1-2  (43) larva L3 puffstage 3-6  (29) larva L3 puffstage 7-9  26 white prepupae new  (29) white prepupae 12hr    23 white prepupae 24hr  26 pupae 2d postWPP  (28) pupae 3d postWPP  (27) pupae 4d postWPP    23 adult male 01day  (51) adult male 05day  (46) adult male 30day  (39) adult female 01day  (44) adult female 05day  (50) adult female 30day  (51) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    19 embryo 04-06hr    5 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    22 embryo 12-14hr    21 embryo 14-16hr    26 embryo 16-18hr    25 embryo 18-20hr    28 embryo 20-22hr    26 embryo 22-24hr    30 larva L1    41 larva L2    62 larva L3 12hr old    65 larva L3 puffstage 1-2    43 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    26 white prepupae new    29 white prepupae 12hr    23 white prepupae 24hr    26 pupae 2d postWPP    28 pupae 3d postWPP    27 pupae 4d postWPP    23 adult male 01day    51 adult male 05day    46 adult male 30day    39 adult female 01day    44 adult female 05day    50 adult female 30day    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    19 embryo 04-06hr    5 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    22 embryo 12-14hr    21 embryo 14-16hr    26 embryo 16-18hr    25 embryo 18-20hr    28 embryo 20-22hr    26 embryo 22-24hr    30 larva L1    41 larva L2    62 larva L3 12hr old    65 larva L3 puffstage 1-2    43 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    26 white prepupae new    29 white prepupae 12hr    23 white prepupae 24hr    26 pupae 2d postWPP    28 pupae 3d postWPP    27 pupae 4d postWPP    23 adult male 01day    51 adult male 05day    46 adult male 30day    39 adult female 01day    44 adult female 05day    50 adult female 30day    51 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    19 embryo 04-06hr    5 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    22 embryo 12-14hr    21 embryo 14-16hr    26 embryo 16-18hr    25 embryo 18-20hr    28 embryo 20-22hr    26 embryo 22-24hr    30 larva L1    41 larva L2    62 larva L3 12hr old    65 larva L3 puffstage 1-2    43 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    26 white prepupae new    29 white prepupae 12hr    23 white prepupae 24hr    26 pupae 2d postWPP    28 pupae 3d postWPP    27 pupae 4d postWPP    23 adult male 01day    51 adult male 05day    46 adult male 30day    39 adult female 01day    44 adult female 05day    50 adult female 30day    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52) embryo 02-04hr    19 embryo 04-06hr    5 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    22 embryo 12-14hr    21 embryo 14-16hr  26 embryo 16-18hr    25 embryo 18-20hr  28 embryo 20-22hr  26 embryo 22-24hr  30 larva L1  (41) larva L2  (62) larva L3 12hr old  (65) larva L3 puffstage 1-2  (43) larva L3 puffstage 3-6  29 larva L3 puffstage 7-9  26 white prepupae new  29 white prepupae 12hr    23 white prepupae 24hr  26 pupae 2d postWPP  28 pupae 3d postWPP  27 pupae 4d postWPP    23 adult male 01day  (51) adult male 05day  (46) adult male 30day  (39) adult female 01day  (44) adult female 05day  (50) adult female 30day  (51) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    19 embryo 04-06hr    5 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    22 embryo 12-14hr    21 embryo 14-16hr    26 embryo 16-18hr    25 embryo 18-20hr    28 embryo 20-22hr    26 embryo 22-24hr    30 larva L1    41 larva L2    62 larva L3 12hr old    65 larva L3 puffstage 1-2    43 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    26 white prepupae new    29 white prepupae 12hr    23 white prepupae 24hr    26 pupae 2d postWPP    28 pupae 3d postWPP    27 pupae 4d postWPP    23 adult male 01day    51 adult male 05day    46 adult male 30day    39 adult female 01day    44 adult female 05day    50 adult female 30day    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    19 embryo 04-06hr    5 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    22 embryo 12-14hr    21 embryo 14-16hr    26 embryo 16-18hr    25 embryo 18-20hr    28 embryo 20-22hr    26 embryo 22-24hr    30 larva L1    41 larva L2    62 larva L3 12hr old    65 larva L3 puffstage 1-2    43 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    26 white prepupae new    29 white prepupae 12hr    23 white prepupae 24hr    26 pupae 2d postWPP    28 pupae 3d postWPP    27 pupae 4d postWPP    23 adult male 01day    51 adult male 05day    46 adult male 30day    39 adult female 01day    44 adult female 05day    50 adult female 30day    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    31 embryonic 1182-4H    32 embryonic GM2    35 embryonic Kc167    13 embryonic S1    44 embryonic S3    83 leg disc CME L1    22 wing disc CME-W2    32 wing disc ML-DmD8    25 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    51 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    45 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    29 ovary fGS/OSS    17 ovary OSC    24 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (59) Schneider line 2 Sg4  (31) embryonic 1182-4H  (32) embryonic GM2  (35) embryonic Kc167    13 embryonic S1  (44) embryonic S3  (83) leg disc CME L1    22 wing disc CME-W2  (32) wing disc ML-DmD8    25 wing disc ML-DmD9  (42) wing disc ML-DmD16-c3    20 wing disc ML-DmD21  (51) wing disc ML-DmD32  (28) haltere disc ML-DmD17-c3  (55) eye-antennal disc ML-DmD11  (64) antennal disc ML-DmD20-c5  (41) mixed discs ML-DmD4-c1  (45) CNS ML-DmBG1-c1  (28) CNS ML-DmBG2-c2  (34) tumorous blood cells mbn2  (29) ovary fGS/OSS    17 ovary OSC    24 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    31 embryonic 1182-4H    32 embryonic GM2    35 embryonic Kc167    13 embryonic S1    44 embryonic S3    83 leg disc CME L1    22 wing disc CME-W2    32 wing disc ML-DmD8    25 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    51 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    45 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    29 ovary fGS/OSS    17 ovary OSC    24 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    31 embryonic 1182-4H    32 embryonic GM2    35 embryonic Kc167    13 embryonic S1    44 embryonic S3    83 leg disc CME L1    22 wing disc CME-W2    32 wing disc ML-DmD8    25 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    51 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    45 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    29 ovary fGS/OSS    17 ovary OSC    24 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    31 embryonic 1182-4H    32 embryonic GM2    35 embryonic Kc167    13 embryonic S1    44 embryonic S3    83 leg disc CME L1    22 wing disc CME-W2    32 wing disc ML-DmD8    25 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    51 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    45 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    29 ovary fGS/OSS    17 ovary OSC    24 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (59) Schneider line 2 Sg4  31 embryonic 1182-4H  32 embryonic GM2  (35) embryonic Kc167    13 embryonic S1  (44) embryonic S3  (83) leg disc CME L1    22 wing disc CME-W2  32 wing disc ML-DmD8    25 wing disc ML-DmD9  (42) wing disc ML-DmD16-c3    20 wing disc ML-DmD21  (51) wing disc ML-DmD32  28 haltere disc ML-DmD17-c3  (55) eye-antennal disc ML-DmD11  (64) antennal disc ML-DmD20-c5  (41) mixed discs ML-DmD4-c1  (45) CNS ML-DmBG1-c1  28 CNS ML-DmBG2-c2  (34) tumorous blood cells mbn2  29 ovary fGS/OSS    17 ovary OSC    24 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    31 embryonic 1182-4H    32 embryonic GM2    35 embryonic Kc167    13 embryonic S1    44 embryonic S3    83 leg disc CME L1    22 wing disc CME-W2    32 wing disc ML-DmD8    25 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    51 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    45 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    29 ovary fGS/OSS    17 ovary OSC    24 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    31 embryonic 1182-4H    32 embryonic GM2    35 embryonic Kc167    13 embryonic S1    44 embryonic S3    83 leg disc CME L1    22 wing disc CME-W2    32 wing disc ML-DmD8    25 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    51 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    64 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    45 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    29 ovary fGS/OSS    17 ovary OSC    24 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    12 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    41 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    48 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    50 Caffeine 1.5 mg/ml 4 hrs, larvae L3    53 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    46 Rotenone 8 μg 12 hrs, larvae L3    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    12 heat shock, 4-day adult  (45) Cadmium 50 mM 6 hrs, larvae L3  (54) Cadmium 50 mM 12 hrs, larvae L3  (36) Cadmium 50 mM 48 hrs, 4-day adult  (41) Cadmium 100 mM 48 hrs, 4-day adult  (37) Copper 0.5 mM 12 hrs, larvae L3  (48) Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (49) Ethanol 5% 3 hrs, larvae L3  (57) Ethanol 10% 3 hrs, larvae L3  (50) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (53) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (39) Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult  (44) Rotenone 2 μg 12 hrs, larvae L3  (46) Rotenone 8 μg 12 hrs, larvae L3  (62) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    12 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    41 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    48 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    50 Caffeine 1.5 mg/ml 4 hrs, larvae L3    53 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    46 Rotenone 8 μg 12 hrs, larvae L3    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    12 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    41 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    48 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    50 Caffeine 1.5 mg/ml 4 hrs, larvae L3    53 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    46 Rotenone 8 μg 12 hrs, larvae L3    62 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    12 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    41 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    48 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    50 Caffeine 1.5 mg/ml 4 hrs, larvae L3    53 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    46 Rotenone 8 μg 12 hrs, larvae L3    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    12 heat shock, 4-day adult  (45) Cadmium 50 mM 6 hrs, larvae L3  (54) Cadmium 50 mM 12 hrs, larvae L3  (36) Cadmium 50 mM 48 hrs, 4-day adult  (41) Cadmium 100 mM 48 hrs, 4-day adult  (37) Copper 0.5 mM 12 hrs, larvae L3  (48) Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (49) Ethanol 5% 3 hrs, larvae L3  (57) Ethanol 10% 3 hrs, larvae L3  (50) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (53) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (39) Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult  (44) Rotenone 2 μg 12 hrs, larvae L3  (46) Rotenone 8 μg 12 hrs, larvae L3  (62) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    12 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    41 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    48 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    50 Caffeine 1.5 mg/ml 4 hrs, larvae L3    53 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    46 Rotenone 8 μg 12 hrs, larvae L3    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    12 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    54 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    41 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    48 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    25 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    57 Ethanol 10% 3 hrs, larvae L3    50 Caffeine 1.5 mg/ml 4 hrs, larvae L3    53 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    39 Caffeine 25 mg/ml 48 hrs, 4-day adult    24 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    46 Rotenone 8 μg 12 hrs, larvae L3    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033465 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12140-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Etf-QOA68V) Etf-QOf05640 Etf-QOG65E Etf-QOS104F lethal (with Etf-QOf05640) Etf-QOA68V Etf-QOG65E Etf-QOS104F lethal (with Etf-QOG65E) Etf-QOA68V Etf-QOf05640 Etf-QOS104F lethal (with Etf-QOS104F) Etf-QOA68V Etf-QOf05640 Etf-QOG65E lethal | embryonic stage | germline clone Etf-QOA68V Etf-QOG65E Etf-QOS104F viable, with Scer\GAL4pnr-MD237 Etf-QOGD5277 Other Phenotypes Allele increased cell death | embryonic stage | germline clone Etf-QOA68V Etf-QOG65E Etf-QOS104F Phenotype manifest in Allele embryonic/larval cuticle Etf-QOG65E Etf-QOA68V Etf-QOS104F
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Etf-QO Class Mutagen Stocks Known lesion Etf-QOf05640 piggyBac transposase 2 -- Etf-QOf01468 piggyBac transposase 1 -- Etf-QOA68V hypomorphic allele - molecular evidence ethyl methanesulfonate 0 Yes Etf-QOG65E hypomorphic allele - molecular evidence ethyl methanesulfonate 0 Yes Etf-QOS104F hypomorphic allele - molecular evidence ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Etf-QO Class Mutagen Stocks Known lesion Etf-QOGD5277 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Etf-QOKK102746 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Etf-QONIG.12140R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Etf-QOf01468 NA PBac{WH}Etf-QOf05640 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
electron-transferring-flavoprotein dehydrogenase activity inferred from direct assay (Alves et al., 2012)
Biological Process
CV term Evidence References
fatty acid beta-oxidation inferred from mutant phenotype (Alves et al., 2012)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008) mitochondrion inferred from direct assay (Alonso et al., 2005)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
electron-transferring-flavoprotein dehydrogenase activity inferred from sequence or structural similarity with UniProtKB:Q08822 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:Q16134 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
oxidative phosphorylation inferred from sequence or structural similarity with UniProtKB:Q16134 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrial inner membrane inferred from sequence or structural similarity with UniProtKB:Q08822 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:Q16134 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Etf-QO allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61859 DroID - A comprehensive database of gene and protein interactions. • FBgn0033465 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36031
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XKVSH Dipteran inclusive ortholog search EOG64QT83 Insect inclusive ortholog search EOG6189HJ Arthropod inclusive ortholog search EOG6XWDCZ Metazoa inclusive ortholog search EOG6C5RBH
Orthologs in Drosophila Species (EOG6XKVSH)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Etf-QO     Drosophila simulans   Dsim\GD10700 Y   Drosophila sechellia   Dsec\GM21168 Y   Drosophila erecta   Dere\GG24120 Y   Drosophila yakuba   Dyak\GE19317 Y   Drosophila ananassae   Dana\GF13564 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11432 Y   Drosophila persimilis   Dper\GL16763 Y   Drosophila willistoni   Dwil\GK15743 Y   Drosophila virilis   Dvir\GJ22483 Y   Drosophila mojavensis   Dmoj\GI19419 Y   Drosophila grimshawi   Dgri\GH20249 Y
Orthologs in non-Drosophila Dipterans (EOG64QT83)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007526   Anopheles gambiae Malaria mosquito  Agam\AGAP005894   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000098
Orthologs in non-Dipteran Insects (EOG6189HJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46322   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008088   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11741   Atta cephalotes Leafcutter ant  Acep\ACEP19019   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21752   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15949   Linepithema humile Argentine ant  Lhum\LH16354   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14297   Solenopsis invicta Red fire ant  Sinv\SINV19287   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003634   Bombyx mori Silkmoth  Bmor\BGIBMGA009420   Pediculus humanus Human body louse  Phum\PHUM061240   Tribolium castaneum Red flour beetle  Tcas\GLEAN_08256
Orthologs in non-Insect Arthropods (EOG6XWDCZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_304399   Daphnia pulex Water flea  Dpux\JGI_V11_116184   Daphnia pulex Water flea  Dpux\JGI_V11_13292   Ixodes scapularis Deer tick  Isca\ISCW019563
Orthologs in non-Arthropod Metazoa (EOG6C5RBH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\let-721   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013502gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002881gn   Danio rerio Zebrafish  Drer\etfdh   Xenopus tropicalis Western clawed frog  Xtro\etfdh   Gallus gallus Domestic chicken  Ggal\ETFDH   Mus musculus House mouse  Mmus\Etfdh   Rattus norvegicus Norway rat  Rnor\Etfdh   Homo sapiens Human  Hsap\ETFDH
Human Orthologs (1)
Gene OMIM HGNC Hsap\ETFDH
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10700 Drosophila sechellia Dsec\GM21168 Drosophila erecta Dere\GG24120 Drosophila yakuba Dyak\GE19317 Drosophila ananassae Dana\GF13564 Drosophila pseudoobscura pseudoobscura Dpse\GA11432 Drosophila persimilis Dper\GL16763 Drosophila willistoni Dwil\GK15743 Drosophila virilis Dvir\GJ22483 Drosophila mojavensis Dmoj\GI19419 Drosophila grimshawi Dgri\GH20249
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	18892 w1118; PBac{WH}Etf-QOf05640
Harvard	- PBac{WH}Etf-QOf01468 - PBac{WH}Etf-QOf05640
VDRC	v15508 w1118; P{GD5277}v15508
Genomic Clones ( 2 )
	BACR01L01 BACR30G11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 35 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH38923
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT13523 GH05935 LD12941 LD24611 LP19825 RE03128 RE05040 RE16579 RE25386 RE52755 RE54177 RH45475
Other clones	45623 76488 104444 145615 Dmel_dig_002683_0682_3603 Dmel_dig_007465_0605_0590 Dmel_dig_017487_0580_2882 Dmel_neb_015437_0919_3057 EK142503 EK161762 EK206425 EK229344 EK298827 IP14035 RP001007551 RP001020490 RP001020845 RP001040571 RP001040795 RP001043081 RP001051208 RP001051521
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033465 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36031
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136692 NM_001259302 RefSeq (Proteins) • NP_610536 NP_001246231 DDBJ / EMBL / GenBank • AAF58873 AAM29591 AFH07986 AY113586 BI634704 CZ483940 CZ488252 Entrez Gene - A searchable database of RefSeq genes. • 36031 UniProtKB/TrEMBL • Q7JWF1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Electron transfer flavoprotein-ubiquinone oxidoreductase (IPR007859) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME12140
Linkouts
	BioGRID - A database of protein and genetic interactions • 61859 DroID - A comprehensive database of gene and protein interactions. • FBgn0033465 DRSC - Results from RNAi screens. • FBgn0033465 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033465 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12140-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033465 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36031 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36031 modMine - Data generated by the modENCODE project. • FBgn0033465
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG12140 (Fujikawa et al., 2009, Cammarato et al., 2011, Alves et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Beller et al., 2006, True et al., 2005, Tripoli et al., 2005, Hughes et al., 2008, Fernández-Ayala et al., 2010, Keleman et al., 2009.8.5, Yano et al., 2012) CG 12140 (Alonso et al., 2005) ETF:QO (Alves et al., 2012) Etf-QO
Name Synonym	electron transfer flavoprotein:ubiquinone oxidoreductase (Alves et al., 2012) Electron transfer flavoprotein-ubiquinone oxidoreductase (Tripoli et al., 2005, )
Secondary FlyBase IDs
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Alves et al., 2012, Biochim. Biophys. Acta 1822(8): 1284--1292 Mutations at the flavin binding site of ETF:QO yield a MADD-like severe phenotype in Drosophila. [FBrf0218632] Yano et al., 2012, J. Neurogenet. 26(1): 53--63 Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843] Show all research papers ...