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Gene Dmel\egr

General Information
Symbol	Dmel\egr	Species	D. melanogaster
Name	eiger	Annotation symbol	CG12919
Feature type	protein_coding_gene	FlyBase ID	FBgn0033483
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	Ect1, regg1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	46E1-46E3	Sequence location	2R:5,965,870..5,971,715 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene eiger is referred to in FlyBase by the symbol Dmel\egr (CG12919, FBgn0033483). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: immune response; asymmetric protein localization involved in cell fate determination; melanization defense response; induction of apoptosis; JNK cascade; defense response to Gram-negative bacterium; apical protein localization. 16 alleles are reported. The phenotypes of these alleles are annotated with: eye; embryonic/larval optic stalk; adult abdomen; wing; scutellum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Tumour necrosis factor; Tumour necrosis factor, conserved site; Tumour necrosis factor-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules, adult heart. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval Malpighian tubules, larval fat body, adult salivary gland, adult carcass. Gene sequence location is 2R:5965870..5971715.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Babcock et al., 2011, Curr. Biol. 21(18): 1525--1533
FB2012_01	Sequence features BKN23624 HFA06233
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 46E1-46E3   Limits computationally determined from genome sequence between P{lacW}Adamk13906&P{EP}Pka-R2EP2162 and P{PZ}14-3-3ζ07103
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\egr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) egr-RA FBtr0088405  NM_165735   2142   415 egr-RB FBtr0088406  NM_206069   2149   409
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein egr-PA   FBpp0087493   46.9   415   5.63     NP_724878   AAF58848 egr-PB   FBpp0087494   46.3   409   5.74     NP_995791   AAS64883
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tumour necrosis factor (IPR006052) Tumour necrosis factor-like (IPR008983) Tumour necrosis factor, conserved site (IPR021184)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58848   AE013599 AAS64883   AB073865 BAC00950   AF149799 AAO15310   AF521176 AAM76710   AI260099   AY115551 AAM66763   AY119233 AAM51093   BG636194   BG640917   BI141711   BI620499   BI635992   BI636564   BI637732   BI638827   BT001838 AAN71595   BT021371 AAX33519   BT072996   CO178511   CO189569   CO280427   CO295235   CO302398   CO302657   CO312588   CO340966   CO344538   EC074045   EC074367   EC195363   EC199338   EC213795   EC241661   EC252599   EC255355   EC255905   GH941124   GH950657   GH961098   GH965589   GH967584   GH967811   GH968494   GH968856   GH970071   GH977144   GH981027   GH981043   GH982637
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IGD3 Q8MRW2 Q8MY88 Q8MUJ1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   dorsal ectoderm anlage   (Stathopoulos et al., 2002)
Additional Descriptive Data
	egr is expressed in the dorsal region of the embryo corresponding to the presumptive dorsal ectoderm. (Stathopoulos et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033483    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033483 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033483 expression level Developmental Stage   Expression Level embryo 00-02hr    196 embryo 02-04hr    3574 embryo 04-06hr    1973 embryo 06-08hr    1060 embryo 08-10hr    1750 embryo 10-12hr    1720 embryo 12-14hr    1836 embryo 14-16hr    1666 embryo 16-18hr    1739 embryo 18-20hr    1793 embryo 20-22hr    2166 embryo 22-24hr    2278 larva L1    1413 larva L2    952 larva L3 12hr old    1038 larva L3 puffstage 1-2    2152 larva L3 puffstage 3-6    2138 larva L3 puffstage 7-9    1736 white prepupae new    1576 white prepupae 12hr    2373 white prepupae 24hr    1654 pupae 2d postWPP    795 pupae 3d postWPP    920 pupae 4d postWPP    811 adult male 01day    1138 adult male 05day    1115 adult male 30day    1315 adult female 01day    763 adult female 05day    426 adult female 30day    532 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (196) embryo 02-04hr  (3574) embryo 04-06hr  (1973) embryo 06-08hr  (1060) embryo 08-10hr  (1750) embryo 10-12hr  (1720) embryo 12-14hr  (1836) embryo 14-16hr  (1666) embryo 16-18hr  (1739) embryo 18-20hr  (1793) embryo 20-22hr  (2166) embryo 22-24hr  (2278) larva L1  (1413) larva L2  (952) larva L3 12hr old  (1038) larva L3 puffstage 1-2  (2152) larva L3 puffstage 3-6  (2138) larva L3 puffstage 7-9  (1736) white prepupae new  (1576) white prepupae 12hr  (2373) white prepupae 24hr  (1654) pupae 2d postWPP  (795) pupae 3d postWPP  (920) pupae 4d postWPP  (811) adult male 01day  (1138) adult male 05day  (1115) adult male 30day  (1315) adult female 01day  (763) adult female 05day  (426) adult female 30day  (532) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    196 embryo 02-04hr  (3574) embryo 04-06hr  (1973) embryo 06-08hr    1060 embryo 08-10hr  (1750) embryo 10-12hr  (1720) embryo 12-14hr  (1836) embryo 14-16hr  (1666) embryo 16-18hr  (1739) embryo 18-20hr  (1793) embryo 20-22hr  (2166) embryo 22-24hr  (2278) larva L1  1413 larva L2    952 larva L3 12hr old    1038 larva L3 puffstage 1-2  (2152) larva L3 puffstage 3-6  (2138) larva L3 puffstage 7-9  (1736) white prepupae new  (1576) white prepupae 12hr  (2373) white prepupae 24hr  (1654) pupae 2d postWPP    795 pupae 3d postWPP    920 pupae 4d postWPP    811 adult male 01day    1138 adult male 05day    1115 adult male 30day    1315 adult female 01day    763 adult female 05day    426 adult female 30day    532 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    196 embryo 02-04hr    3574 embryo 04-06hr    1973 embryo 06-08hr    1060 embryo 08-10hr    1750 embryo 10-12hr    1720 embryo 12-14hr    1836 embryo 14-16hr    1666 embryo 16-18hr    1739 embryo 18-20hr    1793 embryo 20-22hr    2166 embryo 22-24hr    2278 larva L1    1413 larva L2    952 larva L3 12hr old    1038 larva L3 puffstage 1-2    2152 larva L3 puffstage 3-6    2138 larva L3 puffstage 7-9    1736 white prepupae new    1576 white prepupae 12hr    2373 white prepupae 24hr    1654 pupae 2d postWPP    795 pupae 3d postWPP    920 pupae 4d postWPP    811 adult male 01day    1138 adult male 05day    1115 adult male 30day    1315 adult female 01day    763 adult female 05day    426 adult female 30day    532 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    196 embryo 02-04hr    3574 embryo 04-06hr    1973 embryo 06-08hr    1060 embryo 08-10hr    1750 embryo 10-12hr    1720 embryo 12-14hr    1836 embryo 14-16hr    1666 embryo 16-18hr    1739 embryo 18-20hr    1793 embryo 20-22hr    2166 embryo 22-24hr    2278 larva L1    1413 larva L2    952 larva L3 12hr old    1038 larva L3 puffstage 1-2    2152 larva L3 puffstage 3-6    2138 larva L3 puffstage 7-9    1736 white prepupae new    1576 white prepupae 12hr    2373 white prepupae 24hr    1654 pupae 2d postWPP    795 pupae 3d postWPP    920 pupae 4d postWPP    811 adult male 01day    1138 adult male 05day    1115 adult male 30day    1315 adult female 01day    763 adult female 05day    426 adult female 30day    532 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033483 expression level Developmental Stage   Expression Level embryo 00-02hr    196 embryo 02-04hr    3574 embryo 04-06hr    1973 embryo 06-08hr    1060 embryo 08-10hr    1750 embryo 10-12hr    1720 embryo 12-14hr    1836 embryo 14-16hr    1666 embryo 16-18hr    1739 embryo 18-20hr    1793 embryo 20-22hr    2166 embryo 22-24hr    2278 larva L1    1413 larva L2    952 larva L3 12hr old    1038 larva L3 puffstage 1-2    2152 larva L3 puffstage 3-6    2138 larva L3 puffstage 7-9    1736 white prepupae new    1576 white prepupae 12hr    2373 white prepupae 24hr    1654 pupae 2d postWPP    795 pupae 3d postWPP    920 pupae 4d postWPP    811 adult male 01day    1138 adult male 05day    1115 adult male 30day    1315 adult female 01day    763 adult female 05day    426 adult female 30day    532 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (196) embryo 02-04hr  (3574) embryo 04-06hr  (1973) embryo 06-08hr  (1060) embryo 08-10hr  (1750) embryo 10-12hr  (1720) embryo 12-14hr  (1836) embryo 14-16hr  (1666) embryo 16-18hr  (1739) embryo 18-20hr  (1793) embryo 20-22hr  (2166) embryo 22-24hr  (2278) larva L1  (1413) larva L2  (952) larva L3 12hr old  (1038) larva L3 puffstage 1-2  (2152) larva L3 puffstage 3-6  (2138) larva L3 puffstage 7-9  (1736) white prepupae new  (1576) white prepupae 12hr  (2373) white prepupae 24hr  (1654) pupae 2d postWPP  (795) pupae 3d postWPP  (920) pupae 4d postWPP  (811) adult male 01day  (1138) adult male 05day  (1115) adult male 30day  (1315) adult female 01day  (763) adult female 05day  (426) adult female 30day  (532) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    196 embryo 02-04hr  (3574) embryo 04-06hr  1973 embryo 06-08hr    1060 embryo 08-10hr  1750 embryo 10-12hr  1720 embryo 12-14hr  1836 embryo 14-16hr  1666 embryo 16-18hr  1739 embryo 18-20hr  1793 embryo 20-22hr  2166 embryo 22-24hr  2278 larva L1  1413 larva L2    952 larva L3 12hr old    1038 larva L3 puffstage 1-2  2152 larva L3 puffstage 3-6  2138 larva L3 puffstage 7-9  1736 white prepupae new  1576 white prepupae 12hr  2373 white prepupae 24hr  1654 pupae 2d postWPP    795 pupae 3d postWPP    920 pupae 4d postWPP    811 adult male 01day    1138 adult male 05day    1115 adult male 30day    1315 adult female 01day    763 adult female 05day    426 adult female 30day    532 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    196 embryo 02-04hr    3574 embryo 04-06hr    1973 embryo 06-08hr    1060 embryo 08-10hr    1750 embryo 10-12hr    1720 embryo 12-14hr    1836 embryo 14-16hr    1666 embryo 16-18hr    1739 embryo 18-20hr    1793 embryo 20-22hr    2166 embryo 22-24hr    2278 larva L1    1413 larva L2    952 larva L3 12hr old    1038 larva L3 puffstage 1-2    2152 larva L3 puffstage 3-6    2138 larva L3 puffstage 7-9    1736 white prepupae new    1576 white prepupae 12hr    2373 white prepupae 24hr    1654 pupae 2d postWPP    795 pupae 3d postWPP    920 pupae 4d postWPP    811 adult male 01day    1138 adult male 05day    1115 adult male 30day    1315 adult female 01day    763 adult female 05day    426 adult female 30day    532 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    196 embryo 02-04hr    3574 embryo 04-06hr    1973 embryo 06-08hr    1060 embryo 08-10hr    1750 embryo 10-12hr    1720 embryo 12-14hr    1836 embryo 14-16hr    1666 embryo 16-18hr    1739 embryo 18-20hr    1793 embryo 20-22hr    2166 embryo 22-24hr    2278 larva L1    1413 larva L2    952 larva L3 12hr old    1038 larva L3 puffstage 1-2    2152 larva L3 puffstage 3-6    2138 larva L3 puffstage 7-9    1736 white prepupae new    1576 white prepupae 12hr    2373 white prepupae 24hr    1654 pupae 2d postWPP    795 pupae 3d postWPP    920 pupae 4d postWPP    811 adult male 01day    1138 adult male 05day    1115 adult male 30day    1315 adult female 01day    763 adult female 05day    426 adult female 30day    532 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033483    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033483 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules, adult heart. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval Malpighian tubules, larval fat body, adult salivary gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033483 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • S.C2R000679;CG12919-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for egr Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4GMR.PF egrScer\UAS.cIa viable egr1 egr3 egr66 viable, with Scer\GAL4pnr-MD237 egrGD12658 Other Phenotypes Allele immune response defective egr1 egr3 increased cell death, with Scer\GAL4C-765 egrScer\UAS.cMa increased cell death, with Scer\GAL4GMR.PF egrGS9830 egrScer\UAS.cla egrScer\UAS.cMa increased cell death | somatic clone, with Scer\GAL4GMR.PF egrScer\UAS.cIa visible, with Scer\GAL4GMR.PF egrGS9830 egrScer\UAS.cIa egrScer\UAS.cMa visible, with Scer\GAL4pnr-MD237 egrScer\UAS.cIa Phenotype manifest in Allele adult abdomen, with Scer\GAL4sca-537.4 egrGS9830 embryonic/larval hemolymph | third instar larval stage egr1 egr3 embryonic/larval hemolymph | third instar larval stage, with Scer\GAL4He.PZ egrScer\UAS.cIa embryonic/larval optic stalk, with Scer\GAL4GMR.PF egrScer\UAS.cIa eye, with Scer\GAL4GMR.PF egrGS9830 egrScer\UAS.cIa egrScer\UAS.cMa eye | somatic clone, with Scer\GAL4GMR.PF egrScer\UAS.cIa eye-antennal disc | somatic clone, with Scer\GAL4Act5C.PI egrScer\UAS.cIa eye photoreceptor cell | third instar larval stage, with Scer\GAL4GMR.PF egrScer\UAS.cIa macrochaeta & mesothoracic tergum, with Scer\GAL4sca-537.4 egrGS9830 macrochaeta & scutellum, with Scer\GAL4sca-537.4 egrGS9830 scutellum, with Scer\GAL4pnr-MD237 egrScer\UAS.cIa wing, with Scer\GAL4C-765 egrScer\UAS.cMa wing, with Scer\GAL4vg.PM egrGS9830 egrScer\UAS.cIa wing disc | somatic clone, with Scer\GAL4Ubx.PdC egrScer\UAS.cMa
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of egr Class Mutagen Stocks Known lesion egr5-HA-1174 1 -- egre02904 1 -- egre02940 1 -- egrMB06803 1 -- egr1 Delta2-3 0 Yes egr3 Delta2-3 0 Yes egr66 P-element activity 0 Yes egrGS9830 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of egr Class Mutagen Stocks Known lesion egrGD12658 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes egrIR.Scer\UAS in vitro construct 0 Yes egrKK103432 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes egrScer\UAS.cIa in vitro construct - regulatory fusion 0 Yes egrScer\UAS.cla in vitro construct - regulatory fusion 0 Yes egrScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes egrScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes egrΔTNF.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12658} NA P{KK103432} NA P{UAS-eiger.I} NA P{UAS-eiger.IR} NA P{UAS-eiger.M} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS5}egr5-HA-1174 NA P{Switch2}GSG1687 NA PBac{RB}egre02904 NA PBac{RB}egre02940 NA insertion of mobile activating element P{GSV6}egrGS9830 NA P{Mae-UAS.6.11}B2032B2032 NA insertion of enhancer trap binary system Mi{ET1}egrMB06803 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with wgn (Kanda et al., 2002)
Biological Process
CV term Evidence References
apical protein localization inferred from mutant phenotype (Wang et al., 2006) asymmetric protein localization involved in cell fate determination inferred from mutant phenotype (Wang et al., 2006) defense response to Gram-negative bacterium inferred from mutant phenotype (Brandt et al., 2004) immune response inferred from mutant phenotype (Brandt et al., 2004) induction of apoptosis inferred from genetic interaction with th (Igaki et al., 2002) inferred from mutant phenotype (Igaki et al., 2002) JNK cascade inferred from genetic interaction with bsk (Igaki et al., 2002) inferred from genetic interaction with hep (Igaki et al., 2002) inferred from genetic interaction with msn (Igaki et al., 2002) inferred from genetic interaction with Tak1 (Igaki et al., 2002) inferred from mutant phenotype (Igaki et al., 2002) melanization defense response inferred from mutant phenotype (Bidla et al., 2007)
Cellular Component
CV term Evidence References
membrane inferred from direct assay AND inferred from sequence or structural similarity (Igaki et al., 2002) plasma membrane inferred from direct assay (Igaki et al., 2009)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
tumor necrosis factor receptor binding inferred from electronic annotation with InterPro:IPR006052 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Igaki et al., 2002) non-traceable author statement (Igaki, 2001.11.2, Inohara, 1999.5.10, Leclerc and Reichhart, 2004, Moreno, 2002.6.13) traceable author statement (Stathopoulos and Levine, 2004)
Biological Process
CV term Evidence References
apoptotic process non-traceable author statement (Moreno, 2002.6.13, Lawen, 2003) JNK cascade non-traceable author statement (Moreno, 2002.6.13)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions egr allele Gene References egrGS9830 bsk (Igaki et al., 2002) hep (Igaki et al., 2002) Jra (Igaki et al., 2002) msn (Igaki et al., 2002) Nc (Igaki et al., 2002) Tak1 (Igaki et al., 2002) th (Igaki et al., 2002) wgn (Kanda et al., 2002) egrScer\UAS.cMa th (Moreno et al., 2002) unspecified bsk (Geuking et al., 2005) G56 (Geuking et al., 2005) G87 (Geuking et al., 2005) hep (Polaski et al., 2006) Tab2 (Geuking et al., 2005) Tak1 (Polaski et al., 2006, Geuking et al., 2005) Uba1 (Pfleger et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61882 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033483 DroID - A comprehensive database of gene and protein interactions. • FBgn0033483 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36054
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12016 Dere\GG24136 Dgri\GH21919 Dmoj\GI19269 Dper\GL17605 Dpse\GA24841 Dsec\GM21182 Dsim\GD10713 Dvir\GJ22146 Dwil\GK20644 Dyak\GE19335
Curated drosophilid orthologs	Dpse\GA11908
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010524-PA Aedes aegypti (mosquito) AGAP006771-PA Anopheles gambiae (mosquito) XP_001121117.1 Apis mellifera (honey bee) XP_001952590.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000042963 Bos taurus (bovine) CPIJ011491 Culex pipens (mosquito) ENSECAP00000017312 Equus caballus (horse) 164641 Hypsipyla robusta (cedar shoot borer) ENSMUSP00000104290 Mus musculus (house mouse) 200879 Nematostella vectensis (starlet anemone) XP_972476.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12707 LH19458 FBgn0236683 FBgn0222640 FBgn0209260 FBgn0182477 FBgn0176063 JGI_V11_309029 FBgn0246226 FBgn0155208 FBgn0142008 FBgn0129380 FBgn0116269 FBgn0089055 CPIJ011491 BGIBMGA003614 ACYPI51322 ACYPI33077 ACYPI001133 GB16764 AGAP006771 AAEL010524 GLEAN_13579
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	25526 w1118; Mi{ET1}egrMB06803
Harvard	- PBac{RB}egre02904 - PBac{RB}egre02940
Kyoto	125120 w1118; P{RS5}egr5-HA-1174
VDRC	v45252 w1118; P{GD12658}v45252 v45253 w1118; P{GD12658}v45253
Genomic Clones ( 2 )
	BACR06J01 BACR09J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 42 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP03784 RH51659 SD18286
Other clones	DPiM_LP03784 FI04811
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	SD12092 SD13795 SD15611 SD17545 SD19794 SD21218
Other clones	40089 55753 60254 104448 214281.40 214375.58 214481.10 CK01.54A.G10 CK01.71D.A4 EK044557 EK056926 EK154036 EK184056 EK184637 EK209001 EK229348 EP11641 EP19451 RP004170856 RP004219198 RP004235567 RP004235884 RP004270541 RP004301187 RP004432160 RP004449107 RP004454202 RP004462691 RP004465192 RP004491250 RP004539499
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033483 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36054
Antibody Information
Other Information
Discoverer
Etymology
	"eiger" stands for EDA-like cell death trigger. (Igaki et al., 2002) The protein is named "Eiger", in memory of the numerous mountaineers that have been killed by the Eiger Nordwand, the "wall of death". (Moreno et al., 2002)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: eiger CG12919 (FlyBase, 1996-)
Source for database merge of	Source for merge of: egr BcDNA:RH51659 (FlyBase, 1996-)
Additional comments	scaRNA:46E3 is located in intron of egr, on the opposite strand. (Tortoriello et al., 2009) Source for merge of egr BcDNA:RH51659 was a shared cDNA (date:030728). (FlyBase, 1996-) Source for identity of eiger CG12919 was sequence comparison (date:020710). (FlyBase, 1996-)
Other Comments
	Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008) egr is a physiological ligand for the JNK pathway. (Igaki et al., 2002) egr can induce inhibitor-of-apoptosis (IAP)-sensitive cell death through the activation of the JNK pathway. (Igaki et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165735 NM_206069 RefSeq (Proteins) • NP_724878 NP_995791 DDBJ / EMBL / GenBank • AAF58848 AAM51093 AAM66763 AAM76710 AAN71595 AAO15310 AAS64883 AAX33519 AB073865 AF149799 AF521176 AI260099 AY115551 AY119233 BAC00950 BI620499 BI636564 BT001838 BT021371 Entrez Gene - A searchable database of RefSeq genes. • 36054 UniProtKB/TrEMBL • Q8IGD3 Q8MRW2 Q8MUJ1 Q8MY88
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tumour necrosis factor (IPR006052) Tumour necrosis factor-like (IPR008983) Tumour necrosis factor, conserved site (IPR021184)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61882 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033483 DroID - A comprehensive database of gene and protein interactions. • FBgn0033483 DRSC - Results from RNAi screens. • FBgn0033483 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033483 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • S.C2R000679;CG12919-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033483 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36054 InParanoid A subset of ortholog calls from InParanoid. • AAEL010524-PA Aedes aegypti (mosquito) AGAP006771-PA Anopheles gambiae (mosquito) XP_001121117.1 Apis mellifera (honey bee) XP_001952590.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000042963 Bos taurus (bovine) CPIJ011491 Culex pipens (mosquito) ENSECAP00000017312 Equus caballus (horse) 164641 Hypsipyla robusta (cedar shoot borer) ENSMUSP00000104290 Mus musculus (house mouse) 200879 Nematostella vectensis (starlet anemone) XP_972476.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/eiger1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36054 modMine - Data generated by the modENCODE project. • FBgn0033483 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12707 LH19458 FBgn0236683 FBgn0222640 FBgn0209260 FBgn0182477 FBgn0176063 JGI_V11_309029 FBgn0246226 FBgn0155208 FBgn0142008 FBgn0129380 FBgn0116269 FBgn0089055 CPIJ011491 BGIBMGA003614 ACYPI51322 ACYPI33077 ACYPI001133 GB16764 AGAP006771 AAEL010524 GLEAN_13579
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	BcDNA:RH51659   CG12919 (Kai et al., 2005, Lee et al., 2003, Igaki et al., 2002, Grieder et al., 2007, Tortoriello et al., 2009, Keleman et al., 2009.8.5) darth (Chaudhary, 2002.5.28) dt1 (Inohara, 1999.5.10) Ect1 (Stathopoulos and Levine, 2004, Stathopoulos et al., 2002) egr (Pfleger et al., 2007, Peterson et al., 2007, Grieder et al., 2007, Akdemir et al., 2007, Ohsawa et al., 2011, Xue et al., 2007, Gilchrist et al., 2008, Bidla et al., 2007, Igaki et al., 2009, Tortoriello et al., 2009, Maezawa et al., 2009, Igaki et al., 2006, Zeitlinger et al., 2007, Zeitlinger et al., 2007, Geuking et al., 2009, Mallik and Lakhotia, 2009, Sun et al., 2010, Berkey et al., 2009, Froldi et al., 2010, Cordero et al., 2010, Grusche et al., 2011, Portela et al., 2010, Igboin et al., 2011) Egr (Wang et al., 2006, Neisch et al., 2010) regg1 (Igaki et al., 2002) Regg1 (Geuking et al., 2009)
Name Synonym	Drosophila aspartate rich TNF homolog (Chaudhary, 2002.5.28) Eiger (Leclerc and Reichhart, 2004, Moreno and Basler, 2003, Igaki, 2001.11.2, Wang et al., 2006, Bidla et al., 2007, Bauer et al., 2005, Bauer et al., 2005, Kuranaga and Miura, 2007, Brodsky et al., 2004, Xue et al., 2007, Bidla et al., 2007, Kato et al., 2009, Liu et al., 2009, Igaki et al., 2006, Igaki et al., 2006, Wu et al., 2009, Igboin et al., 2011) eiger (Igaki et al., 2002, Brandt et al., 2004, Nicholson et al., 2008, Pfleger et al., 2007, Wu and Silverman, 2007, Tiwari and Roy, 2009, Peterson et al., 2007, Polaski et al., 2006, Ohsawa et al., 2011, Liu and Lehmann, 2008, Zeitouni et al., 2007, Yan et al., 2009, Tortoriello et al., 2009, Zhu et al., 2008, Maezawa et al., 2009, Babcock et al., 2009, Smith-Bolton et al., 2009, Lee et al., 2006, Adelman et al., 2009, Cruz et al., 2009, Arya and Lakhotia, 2008, Firth and Baker, 2007, Sun et al., 2010, Berkey et al., 2009, Froldi et al., 2010, Zhao et al., 2010, Cordero et al., 2010, Rhiner et al., 2010, Tsuda et al., 2010, Portela et al., 2010, Gordon et al., 2008, Jiang et al., 2011) tumor necrosis factor family member DT1 (Inohara, 1999.5.10)
Secondary FlyBase IDs
	FBgn0062838 FBgn0064801
References ( 99 )
Generate a list of	All references relating to this gene ( 99 )
List References by type	Research paper  ( 61 ) Supplementary material  ( 7 ) Review  ( 12 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 4 ) Conference report  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 14 )
	Babcock et al., 2011, Curr. Biol. 21(18): 1525--1533 Hedgehog signaling regulates nociceptive sensitization. [FBrf0216292] Grusche et al., 2011, Dev. Biol. 350(2): 255--266 The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. [FBrf0212888] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Igboin et al., 2011, Infect. Immun. 79(1): 449--458 Porphyromonas gingivalis-Host Interactions in a Drosophila melanogaster Model. [FBrf0212619] Jiang et al., 2011, Oncogene 30(29): 3248--3260 Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. [FBrf0214488] Ohsawa et al., 2011, Dev. Cell 20(3): 315--328 Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila. [FBrf0213219] Cordero et al., 2010, Dev. Cell 18(6): 999--1011 Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. [FBrf0211264] Froldi et al., 2010, BMC Biol. 8: 33 The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy. [FBrf0210873] Neisch et al., 2010, J. Cell Biol. 189(2): 311--323 Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. [FBrf0210554] Portela et al., 2010, Dev. Cell 19(4): 562--573 Drosophila SPARC Is a Self-Protective Signal Expressed by Loser Cells during Cell Competition. [FBrf0212084] Rhiner et al., 2010, Dev. Cell 18(6): 985--998 Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. [FBrf0211273] Sun et al., 2010, J. Biomed. Sci. 17: 27 Damaged DNA-binding protein 2 (DDB2) protects against UV irradiation in human cells and Drosophila. [FBrf0210724] Tsuda et al., 2010, FEBS Lett. 584(22): 4689--4694 POSH promotes cell survival in Drosophila and in human RASF cells. [FBrf0212255] Zhao et al., 2010, PLoS ONE 5(7): e11701 Experimental selection for Drosophila survival in extremely high o(2) environments. [FBrf0211379] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...