A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\KCNQ

General Information
SymbolDmel\KCNQSpeciesD. melanogaster
NameKCNQ potassium channelAnnotation symbolCG33135
Feature typeprotein_coding_geneFlyBase IDFBgn0033494
Gene Model StatusCurrent Stock availability 18 publicly available
Also Known AsDKCNQ, CG12215
Genomic Location
Chromosome (arm)2RRecombination map
Cytogenetic map46F3-46F5Sequence location2R:6,033,402..6,079,899 [-]

Genomic Maps

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modENCODE GBrowse
detailed view
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Automatically generated summary

See sections below for more information
The gene KCNQ potassium channel is referred to in FlyBase by the symbol Dmel\KCNQ (CG33135, FBgn0033494). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: voltage-gated potassium channel activity. There is experimental evidence that it is involved in the biological process: embryonic development via the syncytial blastoderm; cardiac muscle contraction; regulation of heart rate. 34 alleles are reported. The phenotype of these alleles is annotated with: adult heart. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Ion transport; Potassium channel, voltage dependent, KCNQ; Potassium channel, voltage dependent, KCNQ, C-terminal; Voltage-dependent potassium channel. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval hindgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult brain, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1626468_a_at partially aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of KCNQ: 9 out of 10 probes fall into this exonic region. Gene sequence location is 2R:6033402..6079899.

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Description
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FB2011_10
References
Polypeptides
Transcripts
FB2012_01
Alleles
Sequence features
References
Insertions
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
46F3-46F5  
 
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\KCNQ for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0088332 FBtr0301443 FBtr0310093 FBtr0310097 FBtr0301444 FBtr0310096 FBtr0310095 FBtr0299832 FBtr0310094 FBtr0088370 FBtr0088369 FBtr0299833 FBpp0087421 FBpp0289111 FBpp0301794 FBpp0290659 FBpp0301795 FBpp0290658 FBpp0289110 FBpp0301791 FBpp0301792 FBpp0301793 FBpp0087458 FBpp0087457 FBti0052864 FBti0035411 FBti0010825 FBti0038821 FBti0125081 FBti0047781 FBti0069502 FBti0115688 FBti0046678 FBti0053671 FBti0110120 FBti0036234 FBti0070703 FBti0070533 FBti0040041 FBti0055338 FBti0054475 FBti0010864 FBti0036904 FBti0021737 FBti0071156 FBti0112922 FBti0028068 FBti0028069 FBti0145630 FBti0066758 FBti0056354 FBti0049034 FBti0143144 FBti0053051
Comments on Gene Model
Gene model reviewed during 5.42
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0299832
  2149
  683
FBtr0299833
  2969
  774
FBtr0301443
  2702
  808
FBtr0301444
  3257
  993
FBtr0310093
 
  2693
  805
FBtr0310094
 
  2747
  823
FBtr0310095
 
  2795
  839
FBtr0310096
 
  2759
  827
FBtr0310097
 
  2621
  781
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0289110  
77.3  
683  
10.41  
FBpp0289111  
87.1  
774  
9.01  
FBpp0290658  
91.1  
808  
9.09  
FBpp0290659  
110.9  
993  
8.66  
FBpp0301791  
90.8  
805  
9.01  
 
 
FBpp0301792  
93.1  
823  
9.08  
 
 
FBpp0301793  
94.5  
839  
8.85  
 
 
FBpp0301794  
93.2  
827  
9.25  
 
 
FBpp0301795  
88.0  
781  
9.11  
 
 
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view CG18011-RA KCNQ-RE KCNQ-RG KCNQ-RK KCNQ-RF KCNQ-RJ KCNQ-RI KCNQ-RC KCNQ-RH CG12214-RA CG12214-RB KCNQ-RD
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0033494


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0033494
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0033494 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 14
embryo 02-04hr
 
 31
embryo 04-06hr
 
 54
embryo 06-08hr
 
 70
embryo 08-10hr
 
 64
embryo 10-12hr
 
 46
embryo 12-14hr
 
 49
embryo 14-16hr
 
 142
embryo 16-18hr
 
 465
embryo 18-20hr
 
 984
embryo 20-22hr
 
 1368
embryo 22-24hr
 
 1444
larva L1
 
 1521
larva L2
 
 1182
larva L3 12hr old
 
 1669
larva L3 puffstage 1-2
 
 501
larva L3 puffstage 3-6
 
 794
larva L3 puffstage 7-9
 
 784
white prepupae new
 
 281
white prepupae 12hr
 
 230
white prepupae 24hr
 
 98
pupae 2d postWPP
 
 222
pupae 3d postWPP
 
 767
pupae 4d postWPP
 
 801
adult male 01day
 
 905
adult male 05day
 
 877
adult male 30day
 
 916
adult female 01day
 
 633
adult female 05day
 
 316
adult female 30day
 
 294
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 14
embryo 02-04hr
 
 31
embryo 04-06hr
 
 54
embryo 06-08hr
 
 70
embryo 08-10hr
 
 64
embryo 10-12hr
 
 46
embryo 12-14hr
 
 49
embryo 14-16hr
 (142)
embryo 16-18hr
 (465)
embryo 18-20hr
 (984)
embryo 20-22hr
 (1368)
embryo 22-24hr
 (1444)
larva L1
 (1521)
larva L2
 (1182)
larva L3 12hr old
 (1669)
larva L3 puffstage 1-2
 (501)
larva L3 puffstage 3-6
 (794)
larva L3 puffstage 7-9
 (784)
white prepupae new
 (281)
white prepupae 12hr
 (230)
white prepupae 24hr
 
 98
pupae 2d postWPP
 (222)
pupae 3d postWPP
 (767)
pupae 4d postWPP
 (801)
adult male 01day
 (905)
adult male 05day
 (877)
adult male 30day
 (916)
adult female 01day
 (633)
adult female 05day
 (316)
adult female 30day
 (294)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 14
embryo 02-04hr
 
 31
embryo 04-06hr
 
 54
embryo 06-08hr
 
 70
embryo 08-10hr
 
 64
embryo 10-12hr
 
 46
embryo 12-14hr
 
 49
embryo 14-16hr
 
 142
embryo 16-18hr
 
 465
embryo 18-20hr
 
 984
embryo 20-22hr
 
 1368
embryo 22-24hr
 1444
larva L1
 (1521)
larva L2
 
 1182
larva L3 12hr old
 (1669)
larva L3 puffstage 1-2
 
 501
larva L3 puffstage 3-6
 
 794
larva L3 puffstage 7-9
 
 784
white prepupae new
 
 281
white prepupae 12hr
 
 230
white prepupae 24hr
 
 98
pupae 2d postWPP
 
 222
pupae 3d postWPP
 
 767
pupae 4d postWPP
 
 801
adult male 01day
 
 905
adult male 05day
 
 877
adult male 30day
 
 916
adult female 01day
 
 633
adult female 05day
 
 316
adult female 30day
 
 294
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 14
embryo 02-04hr
 
 31
embryo 04-06hr
 
 54
embryo 06-08hr
 
 70
embryo 08-10hr
 
 64
embryo 10-12hr
 
 46
embryo 12-14hr
 
 49
embryo 14-16hr
 
 142
embryo 16-18hr
 
 465
embryo 18-20hr
 
 984
embryo 20-22hr
 
 1368
embryo 22-24hr
 
 1444
larva L1
 
 1521
larva L2
 
 1182
larva L3 12hr old
 
 1669
larva L3 puffstage 1-2
 
 501
larva L3 puffstage 3-6
 
 794
larva L3 puffstage 7-9
 
 784
white prepupae new
 
 281
white prepupae 12hr
 
 230
white prepupae 24hr
 
 98
pupae 2d postWPP
 
 222
pupae 3d postWPP
 
 767
pupae 4d postWPP
 
 801
adult male 01day
 
 905
adult male 05day
 
 877
adult male 30day
 
 916
adult female 01day
 
 633
adult female 05day
 
 316
adult female 30day
 
 294
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 14
embryo 02-04hr
 
 31
embryo 04-06hr
 
 54
embryo 06-08hr
 
 70
embryo 08-10hr
 
 64
embryo 10-12hr
 
 46
embryo 12-14hr
 
 49
embryo 14-16hr
 
 142
embryo 16-18hr
 
 465
embryo 18-20hr
 
 984
embryo 20-22hr
 
 1368
embryo 22-24hr
 
 1444
larva L1
 
 1521
larva L2
 
 1182
larva L3 12hr old
 
 1669
larva L3 puffstage 1-2
 
 501
larva L3 puffstage 3-6
 
 794
larva L3 puffstage 7-9
 
 784
white prepupae new
 
 281
white prepupae 12hr
 
 230
white prepupae 24hr
 
 98
pupae 2d postWPP
 
 222
pupae 3d postWPP
 
 767
pupae 4d postWPP
 
 801
adult male 01day
 
 905
adult male 05day
 
 877
adult male 30day
 
 916
adult female 01day
 
 633
adult female 05day
 
 316
adult female 30day
 
 294
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0033494 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 14
embryo 02-04hr
 
 31
embryo 04-06hr
 
 54
embryo 06-08hr
 
 70
embryo 08-10hr
 
 64
embryo 10-12hr
 
 46
embryo 12-14hr
 
 49
embryo 14-16hr
 
 142
embryo 16-18hr
 
 465
embryo 18-20hr
 
 984
embryo 20-22hr
 
 1368
embryo 22-24hr
 
 1444
larva L1
 
 1521
larva L2
 
 1182
larva L3 12hr old
 
 1669
larva L3 puffstage 1-2
 
 501
larva L3 puffstage 3-6
 
 794
larva L3 puffstage 7-9
 
 784
white prepupae new
 
 281
white prepupae 12hr
 
 230
white prepupae 24hr
 
 98
pupae 2d postWPP
 
 222
pupae 3d postWPP
 
 767
pupae 4d postWPP
 
 801
adult male 01day
 
 905
adult male 05day
 
 877
adult male 30day
 
 916
adult female 01day
 
 633
adult female 05day
 
 316
adult female 30day
 
 294
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 14
embryo 02-04hr
 
 31
embryo 04-06hr
 
 54
embryo 06-08hr
 
 70
embryo 08-10hr
 
 64
embryo 10-12hr
 
 46
embryo 12-14hr
 
 49
embryo 14-16hr
 142
embryo 16-18hr
 (465)
embryo 18-20hr
 (984)
embryo 20-22hr
 (1368)
embryo 22-24hr
 (1444)
larva L1
 (1521)
larva L2
 (1182)
larva L3 12hr old
 (1669)
larva L3 puffstage 1-2
 (501)
larva L3 puffstage 3-6
 (794)
larva L3 puffstage 7-9
 (784)
white prepupae new
 (281)
white prepupae 12hr
 (230)
white prepupae 24hr
 
 98
pupae 2d postWPP
 (222)
pupae 3d postWPP
 (767)
pupae 4d postWPP
 (801)
adult male 01day
 (905)
adult male 05day
 (877)
adult male 30day
 (916)
adult female 01day
 (633)
adult female 05day
 (316)
adult female 30day
 (294)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 14
embryo 02-04hr
 
 31
embryo 04-06hr
 
 54
embryo 06-08hr
 
 70
embryo 08-10hr
 
 64
embryo 10-12hr
 
 46
embryo 12-14hr
 
 49
embryo 14-16hr
 
 142
embryo 16-18hr
 
 465
embryo 18-20hr
 
 984
embryo 20-22hr
 
 1368
embryo 22-24hr
 1444
larva L1
 1521
larva L2
 
 1182
larva L3 12hr old
 1669
larva L3 puffstage 1-2
 
 501
larva L3 puffstage 3-6
 
 794
larva L3 puffstage 7-9
 
 784
white prepupae new
 
 281
white prepupae 12hr
 
 230
white prepupae 24hr
 
 98
pupae 2d postWPP
 
 222
pupae 3d postWPP
 
 767
pupae 4d postWPP
 
 801
adult male 01day
 
 905
adult male 05day
 
 877
adult male 30day
 
 916
adult female 01day
 
 633
adult female 05day
 
 316
adult female 30day
 
 294
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 14
embryo 02-04hr
 
 31
embryo 04-06hr
 
 54
embryo 06-08hr
 
 70
embryo 08-10hr
 
 64
embryo 10-12hr
 
 46
embryo 12-14hr
 
 49
embryo 14-16hr
 
 142
embryo 16-18hr
 
 465
embryo 18-20hr
 
 984
embryo 20-22hr
 
 1368
embryo 22-24hr
 
 1444
larva L1
 
 1521
larva L2
 
 1182
larva L3 12hr old
 
 1669
larva L3 puffstage 1-2
 
 501
larva L3 puffstage 3-6
 
 794
larva L3 puffstage 7-9
 
 784
white prepupae new
 
 281
white prepupae 12hr
 
 230
white prepupae 24hr
 
 98
pupae 2d postWPP
 
 222
pupae 3d postWPP
 
 767
pupae 4d postWPP
 
 801
adult male 01day
 
 905
adult male 05day
 
 877
adult male 30day
 
 916
adult female 01day
 
 633
adult female 05day
 
 316
adult female 30day
 
 294
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 14
embryo 02-04hr
 
 31
embryo 04-06hr
 
 54
embryo 06-08hr
 
 70
embryo 08-10hr
 
 64
embryo 10-12hr
 
 46
embryo 12-14hr
 
 49
embryo 14-16hr
 
 142
embryo 16-18hr
 
 465
embryo 18-20hr
 
 984
embryo 20-22hr
 
 1368
embryo 22-24hr
 
 1444
larva L1
 
 1521
larva L2
 
 1182
larva L3 12hr old
 
 1669
larva L3 puffstage 1-2
 
 501
larva L3 puffstage 3-6
 
 794
larva L3 puffstage 7-9
 
 784
white prepupae new
 
 281
white prepupae 12hr
 
 230
white prepupae 24hr
 
 98
pupae 2d postWPP
 
 222
pupae 3d postWPP
 
 767
pupae 4d postWPP
 
 801
adult male 01day
 
 905
adult male 05day
 
 877
adult male 30day
 
 916
adult female 01day
 
 633
adult female 05day
 
 316
adult female 30day
 
 294
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0033494


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0033494
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval hindgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult brain, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult male accessory gland, larval carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0033494 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 20.225
Larval Midgut
 
 121
Larval Hindgut
 
 832.6
Larval Malpighian Tubules
 
 180.6
Larval Fat Body
 
 7.6
Larval Salivary Gland
 
 62
Larval Trachea
 
 39.075
Larval Carcass
 
 141.35
Adult Head
 
 47.2
Adult Eye
 
 186.3
Adult Brain
 
 139.7
Adult Thoracic-Abdominal Ganglion
 
 78.3
Adult Crop
 
 76.2
Adult Midgut
 
 269.5
Adult Hindgut
 
 170.4
Adult Malpighian Tubules
 
 245.1
Adult Fat Body
 
 7.8
Adult Salivary Gland
 
 67
Adult Heart
 
 17.425
Adult VirginFemale Spermatheca
 
 11.1
Adult InseminatedFemale Spermatheca
 
 14
Adult Ovary
 
 12.4
Adult Testis
 
 10.6
Adult Male Accessory Gland
 
 160.5
Adult Carcass
 
 27
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 20.225
Larval Midgut
 
 121
Larval Hindgut
 (832.6)
Larval Malpighian Tubules
 
 180.6
Larval Fat Body
 
 7.6
Larval Salivary Gland
 
 62
Larval Trachea
 
 39.075
Larval Carcass
 
 141.35
Adult Head
 
 47.2
Adult Eye
 
 186.3
Adult Brain
 
 139.7
Adult Thoracic-Abdominal Ganglion
 
 78.3
Adult Crop
 
 76.2
Adult Midgut
 
 269.5
Adult Hindgut
 
 170.4
Adult Malpighian Tubules
 
 245.1
Adult Fat Body
 
 7.8
Adult Salivary Gland
 
 67
Adult Heart
 
 17.425
Adult VirginFemale Spermatheca
 
 11.1
Adult InseminatedFemale Spermatheca
 
 14
Adult Ovary
 
 12.4
Adult Testis
 
 10.6
Adult Male Accessory Gland
 
 160.5
Adult Carcass
 
 27
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 20.225
Larval Midgut
 
 121
Larval Hindgut
 
 832.6
Larval Malpighian Tubules
 
 180.6
Larval Fat Body
 
 7.6
Larval Salivary Gland
 
 62
Larval Trachea
 
 39.075
Larval Carcass
 
 141.35
Adult Head
 
 47.2
Adult Eye
 
 186.3
Adult Brain
 
 139.7
Adult Thoracic-Abdominal Ganglion
 
 78.3
Adult Crop
 
 76.2
Adult Midgut
 
 269.5
Adult Hindgut
 
 170.4
Adult Malpighian Tubules
 
 245.1
Adult Fat Body
 
 7.8
Adult Salivary Gland
 
 67
Adult Heart
 
 17.425
Adult VirginFemale Spermatheca
 
 11.1
Adult InseminatedFemale Spermatheca
 
 14
Adult Ovary
 
 12.4
Adult Testis
 
 10.6
Adult Male Accessory Gland
 
 160.5
Adult Carcass
 
 27
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 20.225
Larval Midgut
 
 121
Larval Hindgut
 
 832.6
Larval Malpighian Tubules
 
 180.6
Larval Fat Body
 
 7.6
Larval Salivary Gland
 
 62
Larval Trachea
 
 39.075
Larval Carcass
 
 141.35
Adult Head
 
 47.2
Adult Eye
 
 186.3
Adult Brain
 
 139.7
Adult Thoracic-Abdominal Ganglion
 
 78.3
Adult Crop
 
 76.2
Adult Midgut
 
 269.5
Adult Hindgut
 
 170.4
Adult Malpighian Tubules
 
 245.1
Adult Fat Body
 
 7.8
Adult Salivary Gland
 
 67
Adult Heart
 
 17.425
Adult VirginFemale Spermatheca
 
 11.1
Adult InseminatedFemale Spermatheca
 
 14
Adult Ovary
 
 12.4
Adult Testis
 
 10.6
Adult Male Accessory Gland
 
 160.5
Adult Carcass
 
 27
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to maximum FBgn0033494 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 20.225
Larval Midgut
 
 121
Larval Hindgut
 
 832.6
Larval Malpighian Tubules
 
 180.6
Larval Fat Body
 
 7.6
Larval Salivary Gland
 
 62
Larval Trachea
 
 39.075
Larval Carcass
 
 141.35
Adult Head
 
 47.2
Adult Eye
 
 186.3
Adult Brain
 
 139.7
Adult Thoracic-Abdominal Ganglion
 
 78.3
Adult Crop
 
 76.2
Adult Midgut
 
 269.5
Adult Hindgut
 
 170.4
Adult Malpighian Tubules
 
 245.1
Adult Fat Body
 
 7.8
Adult Salivary Gland
 
 67
Adult Heart
 
 17.425
Adult VirginFemale Spermatheca
 
 11.1
Adult InseminatedFemale Spermatheca
 
 14
Adult Ovary
 
 12.4
Adult Testis
 
 10.6
Adult Male Accessory Gland
 
 160.5
Adult Carcass
 
 27
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 20.225
Larval Midgut
 
 121
Larval Hindgut
 (832.6)
Larval Malpighian Tubules
 
 180.6
Larval Fat Body
 
 7.6
Larval Salivary Gland
 
 62
Larval Trachea
 
 39.075
Larval Carcass
 
 141.35
Adult Head
 
 47.2
Adult Eye
 
 186.3
Adult Brain
 
 139.7
Adult Thoracic-Abdominal Ganglion
 
 78.3
Adult Crop
 
 76.2
Adult Midgut
 
 269.5
Adult Hindgut
 
 170.4
Adult Malpighian Tubules
 
 245.1
Adult Fat Body
 
 7.8
Adult Salivary Gland
 
 67
Adult Heart
 
 17.425
Adult VirginFemale Spermatheca
 
 11.1
Adult InseminatedFemale Spermatheca
 
 14
Adult Ovary
 
 12.4
Adult Testis
 
 10.6
Adult Male Accessory Gland
 
 160.5
Adult Carcass
 
 27
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 20.225
Larval Midgut
 
 121
Larval Hindgut
 
 832.6
Larval Malpighian Tubules
 
 180.6
Larval Fat Body
 
 7.6
Larval Salivary Gland
 
 62
Larval Trachea
 
 39.075
Larval Carcass
 
 141.35
Adult Head
 
 47.2
Adult Eye
 
 186.3
Adult Brain
 
 139.7
Adult Thoracic-Abdominal Ganglion
 
 78.3
Adult Crop
 
 76.2
Adult Midgut
 
 269.5
Adult Hindgut
 
 170.4
Adult Malpighian Tubules
 
 245.1
Adult Fat Body
 
 7.8
Adult Salivary Gland
 
 67
Adult Heart
 
 17.425
Adult VirginFemale Spermatheca
 
 11.1
Adult InseminatedFemale Spermatheca
 
 14
Adult Ovary
 
 12.4
Adult Testis
 
 10.6
Adult Male Accessory Gland
 
 160.5
Adult Carcass
 
 27
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 20.225
Larval Midgut
 
 121
Larval Hindgut
 
 832.6
Larval Malpighian Tubules
 
 180.6
Larval Fat Body
 
 7.6
Larval Salivary Gland
 
 62
Larval Trachea
 
 39.075
Larval Carcass
 
 141.35
Adult Head
 
 47.2
Adult Eye
 
 186.3
Adult Brain
 
 139.7
Adult Thoracic-Abdominal Ganglion
 
 78.3
Adult Crop
 
 76.2
Adult Midgut
 
 269.5
Adult Hindgut
 
 170.4
Adult Malpighian Tubules
 
 245.1
Adult Fat Body
 
 7.8
Adult Salivary Gland
 
 67
Adult Heart
 
 17.425
Adult VirginFemale Spermatheca
 
 11.1
Adult InseminatedFemale Spermatheca
 
 14
Adult Ovary
 
 12.4
Adult Testis
 
 10.6
Adult Male Accessory Gland
 
 160.5
Adult Carcass
 
 27
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 47.2
 
NA 
Eye
 
 186.3
 
NA 
Brain
 
 139.7
 
20.225 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 78.3
 
NA 
Crop
 
 76.2
 
121 
Midgut
 
 269.5
 
832.6 
Hindgut
 
 170.4
 
180.6 
Malpighian Tubules
 
 245.1
 
7.6 
Fat Body
 
 7.8
 
62 
Salivary Gland
 
 67
 
NA 
Heart
 
 17.425
 
39.075 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 11.1
 
NA 
InseminatedFemale Spermatheca
 
 14
 
NA 
Ovary
 
 12.4
 
NA 
Testis
 
 10.6
 
NA 
Male Accessory Gland
 
 160.5
 
141.35 
Carcass
 
 27

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
hide Classical Alleles ( 29 )
For All Classical Alleles Show

Allele of KCNQClassMutagenStocksKnown lesion
KCNQCB-0349-3
1 --
KCNQd07206
1 --
KCNQe00818
1 --
KCNQe02600
1 --
KCNQEY083641 --
KCNQf00040
1 --
KCNQf062891 --
KCNQf06625
1 --
KCNQG181511 --
KCNQMI02971
1 --
KCNQNP3423
1 --
KCNQNP4786
1 --
KCNQNP6285
1 --
KCNQ1860 Yes
KCNQ18Bloss of function allele0 Yes
KCNQ35Bloss of function allele0 Yes
KCNQ3700 Yes
KCNQ42B0 Yes
KCNQ53Bloss of function allele0 Yes
KCNQ64Bloss of function allele0 Yes
KCNQ970 Yes
KCNQCB-0350-3
0 --
KCNQd06419
0 --
KCNQe02205
0 --
KCNQEP20740 Yes
KCNQEP2118
0 --
KCNQEP25500 --
KCNQMI04206
0 --
KCNQSH0242
0 --
hide Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show

Allele of KCNQClassMutagenStocksKnown lesion
KCNQGD78652 Yes
KCNQGD37701 Yes
KCNQJF025621 Yes
KCNQKK1090391 Yes
KCNQScer\UAS.cOa0 Yes
hide Aneuploid Aberrations
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
insertion of enhancer trap binary system
insertion of enhancer trap
hide Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
hide Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term
References
Biological Process
CV term
References
inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term
References
inferred from sequence or structural similarity with UniProtKB:Q9NR82
non-traceable author statement
Biological Process
CV term
References
inferred from sequence or structural similarity with UniProtKB:Q9NR82
Cellular Component
CV term
References
inferred from sequence or structural similarity with UniProtKB:Q9NR82
hide Sequence Ontology: Class of Gene
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hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
KCNQ allele
Gene
References
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Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 18 )
Bloomington
Harvard
Kyoto
VDRC
hide Genomic Clones ( 1 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 324 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
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hide Relationship to Other Genes
Source for database identity of
Source for identity of: KCNQ CG12215 CG12915
Source for database merge of
Source for merge of: CG12215 CG12915
Additional comments
Annotations CG12215, CG12915 merged as CG33135 in release 3 of the genome annotation.
hide Other Comments
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym
Name Synonym
KCNQ potassium channel
 
KCNQ-type K+ channel
polyclonal
Secondary FlyBase IDs
  • FBgn0033493
hide References ( 38 )
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hide Recent research papers ( 3 )
Cavaliere and Hodge, 2011, PLoS ONE 6(9): e23898
Drosophila KCNQ Channel Displays Evolutionarily Conserved Electrophysiology and Pharmacology with Mammalian KCNQ Channels. [FBrf0215263]
Neely et al., 2010, Cell 141(1): 142--153
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. [FBrf0210524]
Reddy et al., 2010, Mol. Cell. Biol. 30(21): 5234--5244
Drosophila Transcription Factor Tramtrack69 Binds MEP1 To Recruit the Chromatin Remodeler NuRD. [FBrf0212010]
hide Recent reviews (0)
All reviews listed in FlyBase were published before 2010