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Gene Dmel\CG12214

General Information
Symbol	Dmel\CG12214	Species	D. melanogaster
Name		Annotation symbol	CG12214
Feature type	protein_coding_gene	FlyBase ID	FBgn0033495
Gene Model Status	Current	Stock availability	8 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	46F3-46F3	Sequence location	2R:6,043,895..6,046,436 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG12214 (FBgn0033495). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 12 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Leucine-rich repeat. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, adult hindgut, larval Malpighian tubules, adult heart, adult salivary gland, adult testis, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, adult Malpighian tubules, larval/adult fat body, larval trachea, adult female reproductive system, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1633975_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG12214. Gene sequence location is 2R:6043895..6046436.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN27715 BKN46395 HFA06120
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 46F3-46F3   Limits computationally determined from genome sequence between P{PZ}Pfk06339&P{PZ}CCS03221 and P{lacW}Hr46k10308
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG12214 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG12214-RA FBtr0088370  NM_136718   2190   459 CG12214-RB FBtr0088369  NM_165754   2542   459
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG12214-PA   FBpp0087458   53.1   459   5.13     NP_610562   AAF58828 CG12214-PB   FBpp0087457   53.1   459   5.13     NP_724901   AAM68775
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat (IPR001611)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540733   AA540889   AA567597   AA802670   AA803141   AE013599 AAF58828   AE013599 AAM68775   AI107119   AI107451   AI109340   AI135348   AI258041   AI387113   AI402306   AI402841   AI404474   AI511620   AI511791   AI512115   AI513233   AY051458 AAK92882   BF496092   BF499861   BF501942   BG634120   BG634183   BI172031   BI172064   BI237554   BI241784   BI355493   BI361413   BI361451   BI366264   BI369622   BI481899   BI485100   BI486533   BI579754   BT088951   CL705902   CO271233   CO285966   CO287686   CO300345   CO303217   CO316541   CO322122   CZ472212   CZ473586   CZ477516   CZ477837   CZ490471   EC069887   EC085926   EC089421   EC200496   EC214424   EC234768   EC240170   GH738959   GH739856   GH740289   GH741495   GH741513   GH741987   GH743123   GH744391   GH744760   GH744826   GH761632   GH763859   GH763910   GH766538   GH767575   GH770039   GO254452
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K549
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033495    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033495 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033495 expression level Developmental Stage   Expression Level embryo 00-02hr    2850 embryo 02-04hr    457 embryo 04-06hr    91 embryo 06-08hr    214 embryo 08-10hr    460 embryo 10-12hr    1422 embryo 12-14hr    1203 embryo 14-16hr    1640 embryo 16-18hr    4933 embryo 18-20hr    7180 embryo 20-22hr    2724 embryo 22-24hr    3066 larva L1    759 larva L2    312 larva L3 12hr old    578 larva L3 puffstage 1-2    1090 larva L3 puffstage 3-6    2400 larva L3 puffstage 7-9    3870 white prepupae new    4365 white prepupae 12hr    3458 white prepupae 24hr    2420 pupae 2d postWPP    2370 pupae 3d postWPP    4229 pupae 4d postWPP    5423 adult male 01day    7109 adult male 05day    7828 adult male 30day    5829 adult female 01day    3094 adult female 05day    2376 adult female 30day    2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2850) embryo 02-04hr  (457) embryo 04-06hr    91 embryo 06-08hr  (214) embryo 08-10hr  (460) embryo 10-12hr  (1422) embryo 12-14hr  (1203) embryo 14-16hr  (1640) embryo 16-18hr  (4933) embryo 18-20hr  (7180) embryo 20-22hr  (2724) embryo 22-24hr  (3066) larva L1  (759) larva L2  (312) larva L3 12hr old  (578) larva L3 puffstage 1-2  (1090) larva L3 puffstage 3-6  (2400) larva L3 puffstage 7-9  (3870) white prepupae new  (4365) white prepupae 12hr  (3458) white prepupae 24hr  (2420) pupae 2d postWPP  (2370) pupae 3d postWPP  (4229) pupae 4d postWPP  (5423) adult male 01day  (7109) adult male 05day  (7828) adult male 30day  (5829) adult female 01day  (3094) adult female 05day  (2376) adult female 30day  (2243) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2850) embryo 02-04hr    457 embryo 04-06hr    91 embryo 06-08hr    214 embryo 08-10hr    460 embryo 10-12hr  1422 embryo 12-14hr    1203 embryo 14-16hr  (1640) embryo 16-18hr  (4933) embryo 18-20hr  (7180) embryo 20-22hr  (2724) embryo 22-24hr  (3066) larva L1    759 larva L2    312 larva L3 12hr old    578 larva L3 puffstage 1-2    1090 larva L3 puffstage 3-6  (2400) larva L3 puffstage 7-9  (3870) white prepupae new  (4365) white prepupae 12hr  (3458) white prepupae 24hr  (2420) pupae 2d postWPP  (2370) pupae 3d postWPP  (4229) pupae 4d postWPP  (5423) adult male 01day  (7109) adult male 05day  (7828) adult male 30day  (5829) adult female 01day  (3094) adult female 05day  (2376) adult female 30day  (2243) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2850 embryo 02-04hr    457 embryo 04-06hr    91 embryo 06-08hr    214 embryo 08-10hr    460 embryo 10-12hr    1422 embryo 12-14hr    1203 embryo 14-16hr    1640 embryo 16-18hr    4933 embryo 18-20hr    7180 embryo 20-22hr    2724 embryo 22-24hr    3066 larva L1    759 larva L2    312 larva L3 12hr old    578 larva L3 puffstage 1-2    1090 larva L3 puffstage 3-6    2400 larva L3 puffstage 7-9    3870 white prepupae new    4365 white prepupae 12hr    3458 white prepupae 24hr    2420 pupae 2d postWPP    2370 pupae 3d postWPP    4229 pupae 4d postWPP    5423 adult male 01day    7109 adult male 05day    7828 adult male 30day    5829 adult female 01day    3094 adult female 05day    2376 adult female 30day    2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2850 embryo 02-04hr    457 embryo 04-06hr    91 embryo 06-08hr    214 embryo 08-10hr    460 embryo 10-12hr    1422 embryo 12-14hr    1203 embryo 14-16hr    1640 embryo 16-18hr    4933 embryo 18-20hr    7180 embryo 20-22hr    2724 embryo 22-24hr    3066 larva L1    759 larva L2    312 larva L3 12hr old    578 larva L3 puffstage 1-2    1090 larva L3 puffstage 3-6    2400 larva L3 puffstage 7-9    3870 white prepupae new    4365 white prepupae 12hr    3458 white prepupae 24hr    2420 pupae 2d postWPP    2370 pupae 3d postWPP    4229 pupae 4d postWPP    5423 adult male 01day    7109 adult male 05day    7828 adult male 30day    5829 adult female 01day    3094 adult female 05day    2376 adult female 30day    2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033495 expression level Developmental Stage   Expression Level embryo 00-02hr    2850 embryo 02-04hr    457 embryo 04-06hr    91 embryo 06-08hr    214 embryo 08-10hr    460 embryo 10-12hr    1422 embryo 12-14hr    1203 embryo 14-16hr    1640 embryo 16-18hr    4933 embryo 18-20hr    7180 embryo 20-22hr    2724 embryo 22-24hr    3066 larva L1    759 larva L2    312 larva L3 12hr old    578 larva L3 puffstage 1-2    1090 larva L3 puffstage 3-6    2400 larva L3 puffstage 7-9    3870 white prepupae new    4365 white prepupae 12hr    3458 white prepupae 24hr    2420 pupae 2d postWPP    2370 pupae 3d postWPP    4229 pupae 4d postWPP    5423 adult male 01day    7109 adult male 05day    7828 adult male 30day    5829 adult female 01day    3094 adult female 05day    2376 adult female 30day    2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2850) embryo 02-04hr  (457) embryo 04-06hr    91 embryo 06-08hr  (214) embryo 08-10hr  (460) embryo 10-12hr  (1422) embryo 12-14hr  (1203) embryo 14-16hr  (1640) embryo 16-18hr  (4933) embryo 18-20hr  (7180) embryo 20-22hr  (2724) embryo 22-24hr  (3066) larva L1  (759) larva L2  (312) larva L3 12hr old  (578) larva L3 puffstage 1-2  (1090) larva L3 puffstage 3-6  (2400) larva L3 puffstage 7-9  (3870) white prepupae new  (4365) white prepupae 12hr  (3458) white prepupae 24hr  (2420) pupae 2d postWPP  (2370) pupae 3d postWPP  (4229) pupae 4d postWPP  (5423) adult male 01day  (7109) adult male 05day  (7828) adult male 30day  (5829) adult female 01day  (3094) adult female 05day  (2376) adult female 30day  (2243) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2850) embryo 02-04hr    457 embryo 04-06hr    91 embryo 06-08hr    214 embryo 08-10hr    460 embryo 10-12hr  1422 embryo 12-14hr    1203 embryo 14-16hr  1640 embryo 16-18hr  (4933) embryo 18-20hr  (7180) embryo 20-22hr  (2724) embryo 22-24hr  (3066) larva L1    759 larva L2    312 larva L3 12hr old    578 larva L3 puffstage 1-2    1090 larva L3 puffstage 3-6  2400 larva L3 puffstage 7-9  (3870) white prepupae new  (4365) white prepupae 12hr  (3458) white prepupae 24hr  2420 pupae 2d postWPP  2370 pupae 3d postWPP  (4229) pupae 4d postWPP  (5423) adult male 01day  (7109) adult male 05day  (7828) adult male 30day  (5829) adult female 01day  (3094) adult female 05day  2376 adult female 30day  2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2850 embryo 02-04hr    457 embryo 04-06hr    91 embryo 06-08hr    214 embryo 08-10hr    460 embryo 10-12hr    1422 embryo 12-14hr    1203 embryo 14-16hr    1640 embryo 16-18hr    4933 embryo 18-20hr    7180 embryo 20-22hr    2724 embryo 22-24hr    3066 larva L1    759 larva L2    312 larva L3 12hr old    578 larva L3 puffstage 1-2    1090 larva L3 puffstage 3-6    2400 larva L3 puffstage 7-9    3870 white prepupae new    4365 white prepupae 12hr    3458 white prepupae 24hr    2420 pupae 2d postWPP    2370 pupae 3d postWPP    4229 pupae 4d postWPP    5423 adult male 01day    7109 adult male 05day    7828 adult male 30day    5829 adult female 01day    3094 adult female 05day    2376 adult female 30day    2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2850 embryo 02-04hr    457 embryo 04-06hr    91 embryo 06-08hr    214 embryo 08-10hr    460 embryo 10-12hr    1422 embryo 12-14hr    1203 embryo 14-16hr    1640 embryo 16-18hr    4933 embryo 18-20hr    7180 embryo 20-22hr    2724 embryo 22-24hr    3066 larva L1    759 larva L2    312 larva L3 12hr old    578 larva L3 puffstage 1-2    1090 larva L3 puffstage 3-6    2400 larva L3 puffstage 7-9    3870 white prepupae new    4365 white prepupae 12hr    3458 white prepupae 24hr    2420 pupae 2d postWPP    2370 pupae 3d postWPP    4229 pupae 4d postWPP    5423 adult male 01day    7109 adult male 05day    7828 adult male 30day    5829 adult female 01day    3094 adult female 05day    2376 adult female 30day    2243 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033495    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033495 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, adult hindgut, larval Malpighian tubules, adult heart, adult salivary gland, adult testis, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, adult Malpighian tubules, larval/adult fat body, larval trachea, adult female reproductive system, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033495 expression level Tissue   Expression Level Larval Central Nervous System    104.65 Larval Midgut    478.7 Larval Hindgut    463 Larval Malpighian Tubules    661.5 Larval Fat Body    113.1 Larval Salivary Gland    34.6 Larval Trachea    459.5 Larval Carcass    86.375 Adult Head    677.3 Adult Eye    779.425 Adult Brain    1202.6 Adult Thoracic-Abdominal Ganglion    963.8 Adult Crop    1251.2 Adult Midgut    541.8 Adult Hindgut    900.9 Adult Malpighian Tubules    421.2 Adult Fat Body    410.5 Adult Salivary Gland    811.4 Adult Heart    620.75 Adult VirginFemale Spermatheca    494.2 Adult InseminatedFemale Spermatheca    495.9 Adult Ovary    366.7 Adult Testis    886.9 Adult Male Accessory Gland    473.2 Adult Carcass    757.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    104.65 Larval Midgut    478.7 Larval Hindgut    463 Larval Malpighian Tubules  (661.5) Larval Fat Body    113.1 Larval Salivary Gland    34.6 Larval Trachea    459.5 Larval Carcass    86.375 Adult Head  (677.3) Adult Eye  (779.425) Adult Brain  (1202.6) Adult Thoracic-Abdominal Ganglion  (963.8) Adult Crop  (1251.2) Adult Midgut  (541.8) Adult Hindgut  (900.9) Adult Malpighian Tubules    421.2 Adult Fat Body    410.5 Adult Salivary Gland  (811.4) Adult Heart  (620.75) Adult VirginFemale Spermatheca    494.2 Adult InseminatedFemale Spermatheca    495.9 Adult Ovary    366.7 Adult Testis  (886.9) Adult Male Accessory Gland    473.2 Adult Carcass  (757.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    104.65 Larval Midgut    478.7 Larval Hindgut    463 Larval Malpighian Tubules    661.5 Larval Fat Body    113.1 Larval Salivary Gland    34.6 Larval Trachea    459.5 Larval Carcass    86.375 Adult Head    677.3 Adult Eye    779.425 Adult Brain  (1202.6) Adult Thoracic-Abdominal Ganglion    963.8 Adult Crop  (1251.2) Adult Midgut    541.8 Adult Hindgut    900.9 Adult Malpighian Tubules    421.2 Adult Fat Body    410.5 Adult Salivary Gland    811.4 Adult Heart    620.75 Adult VirginFemale Spermatheca    494.2 Adult InseminatedFemale Spermatheca    495.9 Adult Ovary    366.7 Adult Testis    886.9 Adult Male Accessory Gland    473.2 Adult Carcass    757.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    104.65 Larval Midgut    478.7 Larval Hindgut    463 Larval Malpighian Tubules    661.5 Larval Fat Body    113.1 Larval Salivary Gland    34.6 Larval Trachea    459.5 Larval Carcass    86.375 Adult Head    677.3 Adult Eye    779.425 Adult Brain    1202.6 Adult Thoracic-Abdominal Ganglion    963.8 Adult Crop    1251.2 Adult Midgut    541.8 Adult Hindgut    900.9 Adult Malpighian Tubules    421.2 Adult Fat Body    410.5 Adult Salivary Gland    811.4 Adult Heart    620.75 Adult VirginFemale Spermatheca    494.2 Adult InseminatedFemale Spermatheca    495.9 Adult Ovary    366.7 Adult Testis    886.9 Adult Male Accessory Gland    473.2 Adult Carcass    757.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033495 expression level Tissue   Expression Level Larval Central Nervous System    104.65 Larval Midgut    478.7 Larval Hindgut    463 Larval Malpighian Tubules    661.5 Larval Fat Body    113.1 Larval Salivary Gland    34.6 Larval Trachea    459.5 Larval Carcass    86.375 Adult Head    677.3 Adult Eye    779.425 Adult Brain    1202.6 Adult Thoracic-Abdominal Ganglion    963.8 Adult Crop    1251.2 Adult Midgut    541.8 Adult Hindgut    900.9 Adult Malpighian Tubules    421.2 Adult Fat Body    410.5 Adult Salivary Gland    811.4 Adult Heart    620.75 Adult VirginFemale Spermatheca    494.2 Adult InseminatedFemale Spermatheca    495.9 Adult Ovary    366.7 Adult Testis    886.9 Adult Male Accessory Gland    473.2 Adult Carcass    757.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    104.65 Larval Midgut    478.7 Larval Hindgut    463 Larval Malpighian Tubules  661.5 Larval Fat Body    113.1 Larval Salivary Gland    34.6 Larval Trachea    459.5 Larval Carcass    86.375 Adult Head  677.3 Adult Eye  779.425 Adult Brain  (1202.6) Adult Thoracic-Abdominal Ganglion  (963.8) Adult Crop  (1251.2) Adult Midgut  541.8 Adult Hindgut  (900.9) Adult Malpighian Tubules    421.2 Adult Fat Body    410.5 Adult Salivary Gland  811.4 Adult Heart  620.75 Adult VirginFemale Spermatheca    494.2 Adult InseminatedFemale Spermatheca    495.9 Adult Ovary    366.7 Adult Testis  (886.9) Adult Male Accessory Gland    473.2 Adult Carcass  757.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    104.65 Larval Midgut    478.7 Larval Hindgut    463 Larval Malpighian Tubules    661.5 Larval Fat Body    113.1 Larval Salivary Gland    34.6 Larval Trachea    459.5 Larval Carcass    86.375 Adult Head    677.3 Adult Eye    779.425 Adult Brain  1202.6 Adult Thoracic-Abdominal Ganglion    963.8 Adult Crop  1251.2 Adult Midgut    541.8 Adult Hindgut    900.9 Adult Malpighian Tubules    421.2 Adult Fat Body    410.5 Adult Salivary Gland    811.4 Adult Heart    620.75 Adult VirginFemale Spermatheca    494.2 Adult InseminatedFemale Spermatheca    495.9 Adult Ovary    366.7 Adult Testis    886.9 Adult Male Accessory Gland    473.2 Adult Carcass    757.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    104.65 Larval Midgut    478.7 Larval Hindgut    463 Larval Malpighian Tubules    661.5 Larval Fat Body    113.1 Larval Salivary Gland    34.6 Larval Trachea    459.5 Larval Carcass    86.375 Adult Head    677.3 Adult Eye    779.425 Adult Brain    1202.6 Adult Thoracic-Abdominal Ganglion    963.8 Adult Crop    1251.2 Adult Midgut    541.8 Adult Hindgut    900.9 Adult Malpighian Tubules    421.2 Adult Fat Body    410.5 Adult Salivary Gland    811.4 Adult Heart    620.75 Adult VirginFemale Spermatheca    494.2 Adult InseminatedFemale Spermatheca    495.9 Adult Ovary    366.7 Adult Testis    886.9 Adult Male Accessory Gland    473.2 Adult Carcass    757.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    677.3   NA  Eye    779.425   NA  Brain    1202.6   104.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    963.8   NA  Crop    1251.2   478.7  Midgut    541.8   463  Hindgut    900.9   661.5  Malpighian Tubules    421.2   113.1  Fat Body    410.5   34.6  Salivary Gland    811.4   NA  Heart    620.75   459.5  Trachea    NA   NA  VirginFemale Spermatheca    494.2   NA  InseminatedFemale Spermatheca    495.9   NA  Ovary    366.7   NA  Testis    886.9   NA  Male Accessory Gland    473.2   86.375  Carcass    757.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033495 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12214-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG12214 Stages(s) 1-3 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG12214EY02157 viable, with Scer\GAL4pnr-MD237 CG12214GD7531 Sterility Allele fertile CG12214EY02157 Phenotype manifest in Allele wing | posterior compartment, with Scer\GAL4en-e16E CG12214UY1505
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of CG12214 Class Mutagen Stocks Known lesion CG12214d01405 P-element activity 1 -- CG12214d03837 P-element activity 1 -- CG12214EY02157 P-element activity 1 -- CG12214f07734 piggyBac transposase 1 -- CG12214G18151 P-element activity 1 -- CG12214KG03017 1 -- CG12214d10941 P-element activity 0 -- CG12214d11637 P-element activity 0 -- CG12214e00818 0 -- CG12214UY1505 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG12214 Class Mutagen Stocks Known lesion CG12214GD7531 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG12214KK107715 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7531} NA P{KK107715} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}KCNQEP2118 NA P{EP}KCNQG18151 NA P{EPgy2}CG12214EY02157 NA P{Mae-UAS.6.11}CG12214UY1505 NA P{XP}CG12214d01405 NA P{XP}CG12214d03837 NA P{XP}CG12214d10941 NA P{XP}CG12214d11637 NA miscellaneous insertions P{SUPor-P}CG12214KG03017 NA PBac{RB}KCNQe00818 NA PBac{WH}CG12214f07734 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG12214 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033495 DroID - A comprehensive database of gene and protein interactions. • FBgn0033495 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36072
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12136 Dere\GG25228 Dgri\GH20121 Dmoj\GI20213 Dper\GL10489 Dpse\GA11483 Dsec\GM20547 Dsim\GD26002 Dvir\GJ20163 Dwil\GK10690 Dyak\GE21743
Curated drosophilid orthologs	Dpse\GA11483
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004440-PA Aedes aegypti (mosquito) AGAP011141-PA Anopheles gambiae (mosquito) XP_625182.2 Apis mellifera (honey bee) XP_001944005.1 Acyrthosiphon pisum (pea aphid) 185718 Branchiostoma floridae (lancelet) 67597 Branchiostoma floridae (lancelet) BGIBMGA008544-PA Bombyx mori (silk worm) ENSBTAP00000024242 Bos taurus (bovine) CN15579 Caenorhabditis brenneri (small nematode) CBP03626 Caenorhabditis briggsae (nematode) CE04255 Caenorhabditis elegans (worm) ENSCAFP00000017451 Canis familiaris (dog) JA14381 Caenorhabditis japonica (nematode) CPIJ013337 Culex pipens (mosquito) ENSCPOP00000008911 Cavia porcellus (guinea pig) RP31450 Caenorhabditis remanei (nematode) 44184 Capitella spl (polychaete worm) 309060 Daphnia pulex (daphnia) ENSDARP00000009239 Danio rerio (zebra fish) ENSECAP00000010801 Equus caballus (horse) ENSGACP00000006676 Gymnopilus aculeatus (mushroom) ENSGALP00000029054 Gallus gallus (chicken) ENSP00000284259 Homo sapiens (human) 104573 Lottia gigantea (owl limpet) ENSMODP00000016316 Monodelphis domestica (gray opossum) ENSMMUP00000000114 Macaca mulatta (rhesus monkey) ENSMUSP00000065125 Mus musculus (house mouse) 193641 Nematostella vectensis (starlet anemone) XP_001602437.1 Nasonia vitripennis (wasp) ENSOANP00000010030 Ornithorynchus anatinus (platypus) ENSORLP00000012459 Oryzias latipes (japanese killifish) 30383 Ostreococcus tauri (green alga) MAL7P1.25 Plasmodium falciparum (protozoal parasite) PHUM001456-PA Pediculus humanus (human body louse) ENSPPYP00000004556 Pongo pygmaeus (orangutan) 79394 Phytophthora ramorum (sudden oak death pathogen) 86227 Phytophthora ramorum (sudden oak death pathogen) 128175 Phytophthora sojae (root rot pathogen) 128178 Phytophthora sojae (root rot pathogen) ENSPTRP00000007526 Pan troglodytes (chimpanzee) PVX_087925 Plasmodium vivax (protozoal parasite) ENSRNOP00000047676 Rattus norvegicus (norway rat) XP_795187.1 Strongylocentrotus purpuratus (purple sea urchin) TA14060 Theileria annulata (apicomplexan parasite) XP_973523.2 Tribolium castaneum (red flour beetle) Tc00.1047053506691.80 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508153.980 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017376 Tetraodon nigroviridis (green spotted pufferfish) TP02_0599 Theileria parva (parasitic protozoan) ENSTRUP00000016746 Takifugu rubripes (pufferfish Takifugu) 88141.m00116 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000037162 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15774 LH21886 FBgn0238989 FBgn0212703 FBgn0207303 FBgn0197278 FBgn0175429 JGI_V11_309060 FBgn0071534 FBgn0148099 FBgn0142949 FBgn0127585 FBgn0117352 FBgn0089175 CPIJ013337 BGIBMGA008545 BGIBMGA008544 ACYPI008551 ACYPI006677 GB12899 AGAP011141 AAEL004440 PB21950 PHUM229460 GLEAN_07700
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	20138 y1 w67c23; P{EPgy2}CG12214EY02157 13767 y1 w67c23; P{SUPor-P}CG12214KG03017 27434 y1 w*; P{EP}KCNQG18151 CG12214G18151
Harvard	- P{XP}CG12214d01405 - P{XP}CG12214d03837 - PBac{WH}CG12214f07734
VDRC	v105480 P{KK107715}VIE-260B v31689 w1118; P{GD7531}v31689
Genomic Clones ( 1 )
	BACR09J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 68 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH13040
Other clones	DPiM_GH13040 MIP04546
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09796 AT14632 AT17531 AT30191 AT30310 GH05142 GH06426 GH08491 GH17549 GH21317 GH22148 GH24213 GM06080 GM10304 GM31079 HL01511 LD20523 LD20741 LD43088 LD43315 LD43840 LP01126 RE13954 RE13994 RE33802 RE38951 RE45618 RE45667 RE51765 RE55864 RE64516 RE68375 RE69975 RE73832
Other clones	59157 61570 61582 120630 161651 CK01.78D.G11 CK01.114C.B8 EK061321 EK066506 EK102462 EK178006 EK187254 EK240612 EK265223 RP01442 RP001000337 RP001004387 RP001006722 RP001009101 RP001012847 RP001015796 RP001019820 RP001026089 RP001026579 RP001029059 RP001032319 RP001033383 RP001043970 RP001044562 RP001051700 RP001052433
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033495 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36072
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136718 NM_165754 RefSeq (Proteins) • NP_610562 NP_724901 DDBJ / EMBL / GenBank • AAF58828 AAK92882 AAM68775 AI135348 AI513233 AY051458 CL705902 CZ472212 CZ473586 CZ477516 CZ477837 CZ490471 Entrez Gene - A searchable database of RefSeq genes. • 36072 UniProtKB/TrEMBL • Q7K549
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat (IPR001611)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033495 DroID - A comprehensive database of gene and protein interactions. • FBgn0033495 DRSC - Results from RNAi screens. • FBgn0033495 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033495 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12214-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033495 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36072 InParanoid A subset of ortholog calls from InParanoid. • AAEL004440-PA Aedes aegypti (mosquito) AGAP011141-PA Anopheles gambiae (mosquito) XP_625182.2 Apis mellifera (honey bee) XP_001944005.1 Acyrthosiphon pisum (pea aphid) 185718 Branchiostoma floridae (lancelet) 67597 Branchiostoma floridae (lancelet) BGIBMGA008544-PA Bombyx mori (silk worm) ENSBTAP00000024242 Bos taurus (bovine) CN15579 Caenorhabditis brenneri (small nematode) CBP03626 Caenorhabditis briggsae (nematode) CE04255 Caenorhabditis elegans (worm) ENSCAFP00000017451 Canis familiaris (dog) JA14381 Caenorhabditis japonica (nematode) CPIJ013337 Culex pipens (mosquito) ENSCPOP00000008911 Cavia porcellus (guinea pig) RP31450 Caenorhabditis remanei (nematode) 44184 Capitella spl (polychaete worm) 309060 Daphnia pulex (daphnia) ENSDARP00000009239 Danio rerio (zebra fish) ENSECAP00000010801 Equus caballus (horse) ENSGACP00000006676 Gymnopilus aculeatus (mushroom) ENSGALP00000029054 Gallus gallus (chicken) ENSP00000284259 Homo sapiens (human) 104573 Lottia gigantea (owl limpet) ENSMODP00000016316 Monodelphis domestica (gray opossum) ENSMMUP00000000114 Macaca mulatta (rhesus monkey) ENSMUSP00000065125 Mus musculus (house mouse) 193641 Nematostella vectensis (starlet anemone) XP_001602437.1 Nasonia vitripennis (wasp) ENSOANP00000010030 Ornithorynchus anatinus (platypus) ENSORLP00000012459 Oryzias latipes (japanese killifish) 30383 Ostreococcus tauri (green alga) MAL7P1.25 Plasmodium falciparum (protozoal parasite) PHUM001456-PA Pediculus humanus (human body louse) ENSPPYP00000004556 Pongo pygmaeus (orangutan) 79394 Phytophthora ramorum (sudden oak death pathogen) 86227 Phytophthora ramorum (sudden oak death pathogen) 128175 Phytophthora sojae (root rot pathogen) 128178 Phytophthora sojae (root rot pathogen) ENSPTRP00000007526 Pan troglodytes (chimpanzee) PVX_087925 Plasmodium vivax (protozoal parasite) ENSRNOP00000047676 Rattus norvegicus (norway rat) XP_795187.1 Strongylocentrotus purpuratus (purple sea urchin) TA14060 Theileria annulata (apicomplexan parasite) XP_973523.2 Tribolium castaneum (red flour beetle) Tc00.1047053506691.80 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508153.980 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017376 Tetraodon nigroviridis (green spotted pufferfish) TP02_0599 Theileria parva (parasitic protozoan) ENSTRUP00000016746 Takifugu rubripes (pufferfish Takifugu) 88141.m00116 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000037162 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36072 modMine - Data generated by the modENCODE project. • FBgn0033495 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15774 LH21886 FBgn0238989 FBgn0212703 FBgn0207303 FBgn0197278 FBgn0175429 JGI_V11_309060 FBgn0071534 FBgn0148099 FBgn0142949 FBgn0127585 FBgn0117352 FBgn0089175 CPIJ013337 BGIBMGA008545 BGIBMGA008544 ACYPI008551 ACYPI006677 GB12899 AGAP011141 AAEL004440 PB21950 PHUM229460 GLEAN_07700
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG12214 (Chang et al., 2008, Wang et al., 2004, Keleman et al., 2009.8.5, Pauli et al., 2010)
Name Synonym
Secondary FlyBase IDs
References ( 16 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Pauli et al., 2010, Curr. Biol. 20(20): 1787--1798 A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands. [FBrf0212124] Chang et al., 2008, PLoS ONE 3(9): e3209 Modeling spinal muscular atrophy in Drosophila. [FBrf0206033] Wang et al., 2004, GenomeBiol. 5(9): R69 Function-informed transcriptome analysis of Drosophila renal tubule. [FBrf0180324] Raisin et al., 2003, Genetics 164(3): 1015--1025 A new genetic locus controlling growth and proliferation in Drosophila melanogaster. [FBrf0160859]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Bellen, 2009.5.5, BDGP_2009_0507.GenExel.xml BDGP_2009_0507.GenExel.xml [FBrf0207859] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]