• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Prx2540-2

General Information
Symbol	Dmel\Prx2540-2	Species	D. melanogaster
Name	Peroxiredoxin 2540-2	Annotation symbol	CG11765
Feature type	protein_coding_gene	FlyBase ID	FBgn0033518
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	Prx2540, DPx-2540-2
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	47A7-47A7	Sequence location	2R:6,306,223..6,307,266 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Peroxiredoxin 2540-2 is referred to in FlyBase by the symbol Dmel\Prx2540-2 (CG11765, FBgn0033518). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: thioredoxin peroxidase activity. There is experimental evidence that it is involved in the biological process: hydrogen peroxide catabolic process. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant; Peroxiredoxin, AhpC-type; Peroxiredoxin, C-terminal; Thioredoxin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, adult Malpighian tubules, adult fat body, adult spermathecae, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, adult hindgut, larval Malpighian tubules, adult heart, larval fat body, adult salivary gland, larval trachea, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633471_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Prx2540-2. Gene sequence location is 2R:6306223..6307266.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 47A7-47A7   Limits computationally determined from genome sequence between P{lacW}Hr46k10308 and P{PZ}lola00349&P{EP}lolaEP952
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Prx2540-2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Gene model reviewed during 5.44
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Prx2540-2-RA FBtr0088259  NM_078959   856   220
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Prx2540-2-PA   FBpp0087354   24.8   220   6.39     NP_523683   AAF58799
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant (IPR000866) Thioredoxin-like fold (IPR012336) Peroxiredoxin, C-terminal (IPR019479) Peroxiredoxin, AhpC-type (IPR024706)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58799   AF311880 AAG47824   AI533858   AY070952 AAL48574   AY075444   AY094953 AAM11306   BE976860   BE978069   BG636635   BG640900   BI141851   BI165247   BI483132   BI604278   BI615073   BI626463   BI632195   BI632616   BI633019   BI635192   BI635888   BI637168   BI638403   BI640290   BI641833   BP542475   BP549355   BP553192   BP554023   BP554363   BT120318   BT126013   CA807681   CO153480   CO155571   CO181234   EC267292   EC267510   GH740692   GH742396   GH742883   GH747357   GH765094   GH767181
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JX87 Q9GPQ0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi hindgut anlage in statu nascendi   (Fisher et al., 2012) posterior ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi yolk nucleus   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   yolk nucleus   (Fisher et al., 2012) embryonic stage 13 -- 16   plasmatocyte   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | intense   (Radyuk et al., 2001) third instar larval stage   organism | faint   (Radyuk et al., 2001) pupal stage   organism | faint   (Radyuk et al., 2001) day 1 of adulthood & male -- day 2 of adulthood & male   organism | faint   (Radyuk et al., 2001)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytosol inferred from direct assay (Radyuk et al., 2001)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, adult Malpighian tubules, adult fat body, adult spermathecae, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, adult hindgut, larval Malpighian tubules, adult heart, larval fat body, adult salivary gland, larval trachea, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    6.45 Larval Midgut    4487.8 Larval Hindgut    1612.7 Larval Malpighian Tubules    246.4 Larval Fat Body    210.4 Larval Salivary Gland    75.5 Larval Trachea    148.475 Larval Carcass    95.85 Adult Head    408.6 Adult Eye    78.7 Adult Brain    18 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    186.2 Adult Midgut    1654.4 Adult Hindgut    269.8 Adult Malpighian Tubules    556.2 Adult Fat Body    547.4 Adult Salivary Gland    304.3 Adult Heart    348.15 Adult VirginFemale Spermatheca    1335.4 Adult InseminatedFemale Spermatheca    719 Adult Ovary    48.2 Adult Testis    1670.7 Adult Male Accessory Gland    55.4 Adult Carcass    251.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.45 Larval Midgut  (4487.8) Larval Hindgut  (1612.7) Larval Malpighian Tubules    246.4 Larval Fat Body    210.4 Larval Salivary Gland    75.5 Larval Trachea    148.475 Larval Carcass    95.85 Adult Head    408.6 Adult Eye    78.7 Adult Brain    18 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    186.2 Adult Midgut  (1654.4) Adult Hindgut    269.8 Adult Malpighian Tubules  (556.2) Adult Fat Body  (547.4) Adult Salivary Gland    304.3 Adult Heart    348.15 Adult VirginFemale Spermatheca  (1335.4) Adult InseminatedFemale Spermatheca  (719) Adult Ovary    48.2 Adult Testis  (1670.7) Adult Male Accessory Gland    55.4 Adult Carcass    251.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.45 Larval Midgut  (4487.8) Larval Hindgut  (1612.7) Larval Malpighian Tubules    246.4 Larval Fat Body    210.4 Larval Salivary Gland    75.5 Larval Trachea    148.475 Larval Carcass    95.85 Adult Head    408.6 Adult Eye    78.7 Adult Brain    18 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    186.2 Adult Midgut  (1654.4) Adult Hindgut    269.8 Adult Malpighian Tubules    556.2 Adult Fat Body    547.4 Adult Salivary Gland    304.3 Adult Heart    348.15 Adult VirginFemale Spermatheca  (1335.4) Adult InseminatedFemale Spermatheca    719 Adult Ovary    48.2 Adult Testis  (1670.7) Adult Male Accessory Gland    55.4 Adult Carcass    251.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.45 Larval Midgut    4487.8 Larval Hindgut    1612.7 Larval Malpighian Tubules    246.4 Larval Fat Body    210.4 Larval Salivary Gland    75.5 Larval Trachea    148.475 Larval Carcass    95.85 Adult Head    408.6 Adult Eye    78.7 Adult Brain    18 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    186.2 Adult Midgut    1654.4 Adult Hindgut    269.8 Adult Malpighian Tubules    556.2 Adult Fat Body    547.4 Adult Salivary Gland    304.3 Adult Heart    348.15 Adult VirginFemale Spermatheca    1335.4 Adult InseminatedFemale Spermatheca    719 Adult Ovary    48.2 Adult Testis    1670.7 Adult Male Accessory Gland    55.4 Adult Carcass    251.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    6.45 Larval Midgut    4487.8 Larval Hindgut    1612.7 Larval Malpighian Tubules    246.4 Larval Fat Body    210.4 Larval Salivary Gland    75.5 Larval Trachea    148.475 Larval Carcass    95.85 Adult Head    408.6 Adult Eye    78.7 Adult Brain    18 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    186.2 Adult Midgut    1654.4 Adult Hindgut    269.8 Adult Malpighian Tubules    556.2 Adult Fat Body    547.4 Adult Salivary Gland    304.3 Adult Heart    348.15 Adult VirginFemale Spermatheca    1335.4 Adult InseminatedFemale Spermatheca    719 Adult Ovary    48.2 Adult Testis    1670.7 Adult Male Accessory Gland    55.4 Adult Carcass    251.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.45 Larval Midgut  (4487.8) Larval Hindgut  (1612.7) Larval Malpighian Tubules    246.4 Larval Fat Body    210.4 Larval Salivary Gland    75.5 Larval Trachea    148.475 Larval Carcass    95.85 Adult Head    408.6 Adult Eye    78.7 Adult Brain    18 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    186.2 Adult Midgut  (1654.4) Adult Hindgut    269.8 Adult Malpighian Tubules  556.2 Adult Fat Body  547.4 Adult Salivary Gland    304.3 Adult Heart    348.15 Adult VirginFemale Spermatheca  (1335.4) Adult InseminatedFemale Spermatheca  719 Adult Ovary    48.2 Adult Testis  (1670.7) Adult Male Accessory Gland    55.4 Adult Carcass    251.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.45 Larval Midgut  (4487.8) Larval Hindgut  1612.7 Larval Malpighian Tubules    246.4 Larval Fat Body    210.4 Larval Salivary Gland    75.5 Larval Trachea    148.475 Larval Carcass    95.85 Adult Head    408.6 Adult Eye    78.7 Adult Brain    18 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    186.2 Adult Midgut  1654.4 Adult Hindgut    269.8 Adult Malpighian Tubules    556.2 Adult Fat Body    547.4 Adult Salivary Gland    304.3 Adult Heart    348.15 Adult VirginFemale Spermatheca  1335.4 Adult InseminatedFemale Spermatheca    719 Adult Ovary    48.2 Adult Testis  1670.7 Adult Male Accessory Gland    55.4 Adult Carcass    251.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.45 Larval Midgut    4487.8 Larval Hindgut    1612.7 Larval Malpighian Tubules    246.4 Larval Fat Body    210.4 Larval Salivary Gland    75.5 Larval Trachea    148.475 Larval Carcass    95.85 Adult Head    408.6 Adult Eye    78.7 Adult Brain    18 Adult Thoracic-Abdominal Ganglion    15.6 Adult Crop    186.2 Adult Midgut    1654.4 Adult Hindgut    269.8 Adult Malpighian Tubules    556.2 Adult Fat Body    547.4 Adult Salivary Gland    304.3 Adult Heart    348.15 Adult VirginFemale Spermatheca    1335.4 Adult InseminatedFemale Spermatheca    719 Adult Ovary    48.2 Adult Testis    1670.7 Adult Male Accessory Gland    55.4 Adult Carcass    251.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    408.6   NA  Eye    78.7   NA  Brain    18   6.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    15.6   NA  Crop    186.2   4487.8  Midgut    1654.4   1612.7  Hindgut    269.8   246.4  Malpighian Tubules    556.2   210.4  Fat Body    547.4   75.5  Salivary Gland    304.3   NA  Heart    348.15   148.475  Trachea    NA   NA  VirginFemale Spermatheca    1335.4   NA  InseminatedFemale Spermatheca    719   NA  Ovary    48.2   NA  Testis    1670.7   NA  Male Accessory Gland    55.4   95.85  Carcass    251.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    87 head, virgin 4-day female    18 head, virgin 20-day female    84 head, mated 1-day female    41 head, mated 4-day female    42 head, mated 20-day female    45 head, mated 1-day male    64 head, mated 4-day male    55 head, mated 20-day male    78 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    25 digestive system, 4-day adult    19 digestive system, 20-day adult    41 fat body, larvae L3 wandering    58 fat body, white prepupae    37 fat body, pupae P8    30 carcass, larvae L3 wandering    3 carcass, 1-day adult    65 carcass, 4-day adult    43 carcass, 20-day adult    77 ovary, virgin 4-day female    17 ovary, mated 4-day female    13 testis, mated 4-day male    161 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female  (87) head, virgin 4-day female    18 head, virgin 20-day female  (84) head, mated 1-day female  (41) head, mated 4-day female  (42) head, mated 20-day female  (45) head, mated 1-day male  (64) head, mated 4-day male  (55) head, mated 20-day male  (78) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    25 digestive system, 4-day adult    19 digestive system, 20-day adult  (41) fat body, larvae L3 wandering  (58) fat body, white prepupae  (37) fat body, pupae P8  (30) carcass, larvae L3 wandering    3 carcass, 1-day adult  (65) carcass, 4-day adult  (43) carcass, 20-day adult  (77) ovary, virgin 4-day female    17 ovary, mated 4-day female    13 testis, mated 4-day male  (161) accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    87 head, virgin 4-day female    18 head, virgin 20-day female    84 head, mated 1-day female    41 head, mated 4-day female    42 head, mated 20-day female    45 head, mated 1-day male    64 head, mated 4-day male    55 head, mated 20-day male    78 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    25 digestive system, 4-day adult    19 digestive system, 20-day adult    41 fat body, larvae L3 wandering    58 fat body, white prepupae    37 fat body, pupae P8    30 carcass, larvae L3 wandering    3 carcass, 1-day adult    65 carcass, 4-day adult    43 carcass, 20-day adult    77 ovary, virgin 4-day female    17 ovary, mated 4-day female    13 testis, mated 4-day male  (161) accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    87 head, virgin 4-day female    18 head, virgin 20-day female    84 head, mated 1-day female    41 head, mated 4-day female    42 head, mated 20-day female    45 head, mated 1-day male    64 head, mated 4-day male    55 head, mated 20-day male    78 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    25 digestive system, 4-day adult    19 digestive system, 20-day adult    41 fat body, larvae L3 wandering    58 fat body, white prepupae    37 fat body, pupae P8    30 carcass, larvae L3 wandering    3 carcass, 1-day adult    65 carcass, 4-day adult    43 carcass, 20-day adult    77 ovary, virgin 4-day female    17 ovary, mated 4-day female    13 testis, mated 4-day male    161 accessory gland, mated 4-day male    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    87 head, virgin 4-day female    18 head, virgin 20-day female    84 head, mated 1-day female    41 head, mated 4-day female    42 head, mated 20-day female    45 head, mated 1-day male    64 head, mated 4-day male    55 head, mated 20-day male    78 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    25 digestive system, 4-day adult    19 digestive system, 20-day adult    41 fat body, larvae L3 wandering    58 fat body, white prepupae    37 fat body, pupae P8    30 carcass, larvae L3 wandering    3 carcass, 1-day adult    65 carcass, 4-day adult    43 carcass, 20-day adult    77 ovary, virgin 4-day female    17 ovary, mated 4-day female    13 testis, mated 4-day male    161 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female  (87) head, virgin 4-day female    18 head, virgin 20-day female  (84) head, mated 1-day female  (41) head, mated 4-day female  (42) head, mated 20-day female  (45) head, mated 1-day male  (64) head, mated 4-day male  (55) head, mated 20-day male  (78) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    25 digestive system, 4-day adult    19 digestive system, 20-day adult  (41) fat body, larvae L3 wandering  (58) fat body, white prepupae  (37) fat body, pupae P8  30 carcass, larvae L3 wandering    3 carcass, 1-day adult  (65) carcass, 4-day adult  (43) carcass, 20-day adult  (77) ovary, virgin 4-day female    17 ovary, mated 4-day female    13 testis, mated 4-day male  (161) accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    87 head, virgin 4-day female    18 head, virgin 20-day female    84 head, mated 1-day female    41 head, mated 4-day female    42 head, mated 20-day female    45 head, mated 1-day male    64 head, mated 4-day male    55 head, mated 20-day male    78 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    25 digestive system, 4-day adult    19 digestive system, 20-day adult    41 fat body, larvae L3 wandering    58 fat body, white prepupae    37 fat body, pupae P8    30 carcass, larvae L3 wandering    3 carcass, 1-day adult    65 carcass, 4-day adult    43 carcass, 20-day adult    77 ovary, virgin 4-day female    17 ovary, mated 4-day female    13 testis, mated 4-day male  (161) accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    87 head, virgin 4-day female    18 head, virgin 20-day female    84 head, mated 1-day female    41 head, mated 4-day female    42 head, mated 20-day female    45 head, mated 1-day male    64 head, mated 4-day male    55 head, mated 20-day male    78 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    25 digestive system, 4-day adult    19 digestive system, 20-day adult    41 fat body, larvae L3 wandering    58 fat body, white prepupae    37 fat body, pupae P8    30 carcass, larvae L3 wandering    3 carcass, 1-day adult    65 carcass, 4-day adult    43 carcass, 20-day adult    77 ovary, virgin 4-day female    17 ovary, mated 4-day female    13 testis, mated 4-day male    161 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    11 embryo 04-06hr    8 embryo 06-08hr    29 embryo 08-10hr    82 embryo 10-12hr    54 embryo 12-14hr    31 embryo 14-16hr    11 embryo 16-18hr    25 embryo 18-20hr    27 embryo 20-22hr    32 embryo 22-24hr    23 larva L1    8 larva L2    16 larva L3 12hr old    20 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    29 white prepupae 24hr    18 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    24 adult male 01day    32 adult male 05day    33 adult male 30day    13 adult female 01day    12 adult female 05day    7 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    11 embryo 04-06hr    8 embryo 06-08hr  (29) embryo 08-10hr  (82) embryo 10-12hr  (54) embryo 12-14hr  (31) embryo 14-16hr    11 embryo 16-18hr    25 embryo 18-20hr  (27) embryo 20-22hr  (32) embryo 22-24hr    23 larva L1    8 larva L2    16 larva L3 12hr old    20 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr  (29) white prepupae 24hr    18 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    24 adult male 01day  (32) adult male 05day  (33) adult male 30day    13 adult female 01day    12 adult female 05day    7 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    11 embryo 04-06hr    8 embryo 06-08hr    29 embryo 08-10hr    82 embryo 10-12hr    54 embryo 12-14hr    31 embryo 14-16hr    11 embryo 16-18hr    25 embryo 18-20hr    27 embryo 20-22hr    32 embryo 22-24hr    23 larva L1    8 larva L2    16 larva L3 12hr old    20 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    29 white prepupae 24hr    18 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    24 adult male 01day    32 adult male 05day    33 adult male 30day    13 adult female 01day    12 adult female 05day    7 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    11 embryo 04-06hr    8 embryo 06-08hr    29 embryo 08-10hr    82 embryo 10-12hr    54 embryo 12-14hr    31 embryo 14-16hr    11 embryo 16-18hr    25 embryo 18-20hr    27 embryo 20-22hr    32 embryo 22-24hr    23 larva L1    8 larva L2    16 larva L3 12hr old    20 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    29 white prepupae 24hr    18 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    24 adult male 01day    32 adult male 05day    33 adult male 30day    13 adult female 01day    12 adult female 05day    7 adult female 30day    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    11 embryo 04-06hr    8 embryo 06-08hr    29 embryo 08-10hr    82 embryo 10-12hr    54 embryo 12-14hr    31 embryo 14-16hr    11 embryo 16-18hr    25 embryo 18-20hr    27 embryo 20-22hr    32 embryo 22-24hr    23 larva L1    8 larva L2    16 larva L3 12hr old    20 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    29 white prepupae 24hr    18 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    24 adult male 01day    32 adult male 05day    33 adult male 30day    13 adult female 01day    12 adult female 05day    7 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    11 embryo 04-06hr    8 embryo 06-08hr  29 embryo 08-10hr  (82) embryo 10-12hr  (54) embryo 12-14hr  31 embryo 14-16hr    11 embryo 16-18hr    25 embryo 18-20hr  27 embryo 20-22hr  32 embryo 22-24hr    23 larva L1    8 larva L2    16 larva L3 12hr old    20 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr  29 white prepupae 24hr    18 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    24 adult male 01day  32 adult male 05day  (33) adult male 30day    13 adult female 01day    12 adult female 05day    7 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    11 embryo 04-06hr    8 embryo 06-08hr    29 embryo 08-10hr    82 embryo 10-12hr    54 embryo 12-14hr    31 embryo 14-16hr    11 embryo 16-18hr    25 embryo 18-20hr    27 embryo 20-22hr    32 embryo 22-24hr    23 larva L1    8 larva L2    16 larva L3 12hr old    20 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    29 white prepupae 24hr    18 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    24 adult male 01day    32 adult male 05day    33 adult male 30day    13 adult female 01day    12 adult female 05day    7 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    11 embryo 04-06hr    8 embryo 06-08hr    29 embryo 08-10hr    82 embryo 10-12hr    54 embryo 12-14hr    31 embryo 14-16hr    11 embryo 16-18hr    25 embryo 18-20hr    27 embryo 20-22hr    32 embryo 22-24hr    23 larva L1    8 larva L2    16 larva L3 12hr old    20 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    29 white prepupae 24hr    18 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    24 adult male 01day    32 adult male 05day    33 adult male 30day    13 adult female 01day    12 adult female 05day    7 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    9 embryonic 1182-4H    170 embryonic GM2    12 embryonic Kc167    2 embryonic S1    9 embryonic S3    7 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    84 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    12 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (55) Schneider line 2 Sg4    9 embryonic 1182-4H  (170) embryonic GM2    12 embryonic Kc167    2 embryonic S1    9 embryonic S3    7 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11  (84) antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2  (58) tumorous blood cells mbn2    12 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    9 embryonic 1182-4H  (170) embryonic GM2    12 embryonic Kc167    2 embryonic S1    9 embryonic S3    7 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    84 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    12 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    9 embryonic 1182-4H    170 embryonic GM2    12 embryonic Kc167    2 embryonic S1    9 embryonic S3    7 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    84 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    12 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    9 embryonic 1182-4H    170 embryonic GM2    12 embryonic Kc167    2 embryonic S1    9 embryonic S3    7 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    84 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    12 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (55) Schneider line 2 Sg4    9 embryonic 1182-4H  (170) embryonic GM2    12 embryonic Kc167    2 embryonic S1    9 embryonic S3    7 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11  (84) antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2  (58) tumorous blood cells mbn2    12 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    9 embryonic 1182-4H  (170) embryonic GM2    12 embryonic Kc167    2 embryonic S1    9 embryonic S3    7 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    84 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    12 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    55 Schneider line 2 Sg4    9 embryonic 1182-4H    170 embryonic GM2    12 embryonic Kc167    2 embryonic S1    9 embryonic S3    7 leg disc CME L1    7 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    23 eye-antennal disc ML-DmD11    84 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    12 ovary fGS/OSS    6 ovary OSC    1 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    15 heat shock, 4-day adult    43 Cadmium 50 mM 6 hrs, larvae L3    47 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    36 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    102 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    32 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    59 Caffeine 1.5 mg/ml 4 hrs, larvae L3    108 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    80 Rotenone 2 μg 12 hrs, larvae L3    149 Rotenone 8 μg 12 hrs, larvae L3    158 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    15 heat shock, 4-day adult  (43) Cadmium 50 mM 6 hrs, larvae L3  (47) Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult  (36) Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3  (102) Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult  (32) Ethanol 2.5% 3 hrs, larvae L3  (40) Ethanol 5% 3 hrs, larvae L3  (48) Ethanol 10% 3 hrs, larvae L3  (59) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (108) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (36) Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult  (36) Paraquat 10 mM 48 hrs, 4-day adult  (80) Rotenone 2 μg 12 hrs, larvae L3  (149) Rotenone 8 μg 12 hrs, larvae L3  (158) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    15 heat shock, 4-day adult    43 Cadmium 50 mM 6 hrs, larvae L3    47 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    36 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3  102 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    32 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    59 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (108) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    80 Rotenone 2 μg 12 hrs, larvae L3  (149) Rotenone 8 μg 12 hrs, larvae L3  (158) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    15 heat shock, 4-day adult    43 Cadmium 50 mM 6 hrs, larvae L3    47 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    36 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    102 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    32 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    59 Caffeine 1.5 mg/ml 4 hrs, larvae L3    108 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    80 Rotenone 2 μg 12 hrs, larvae L3    149 Rotenone 8 μg 12 hrs, larvae L3    158 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    15 heat shock, 4-day adult    43 Cadmium 50 mM 6 hrs, larvae L3    47 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    36 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    102 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    32 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    59 Caffeine 1.5 mg/ml 4 hrs, larvae L3    108 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    80 Rotenone 2 μg 12 hrs, larvae L3    149 Rotenone 8 μg 12 hrs, larvae L3    158 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    15 heat shock, 4-day adult  (43) Cadmium 50 mM 6 hrs, larvae L3  (47) Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult  (36) Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3  (102) Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult  32 Ethanol 2.5% 3 hrs, larvae L3  (40) Ethanol 5% 3 hrs, larvae L3  (48) Ethanol 10% 3 hrs, larvae L3  (59) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (108) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (36) Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult  (36) Paraquat 10 mM 48 hrs, 4-day adult  (80) Rotenone 2 μg 12 hrs, larvae L3  (149) Rotenone 8 μg 12 hrs, larvae L3  (158) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    15 heat shock, 4-day adult    43 Cadmium 50 mM 6 hrs, larvae L3    47 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    36 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3  102 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    32 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    59 Caffeine 1.5 mg/ml 4 hrs, larvae L3  108 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    80 Rotenone 2 μg 12 hrs, larvae L3  (149) Rotenone 8 μg 12 hrs, larvae L3  (158) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    15 heat shock, 4-day adult    43 Cadmium 50 mM 6 hrs, larvae L3    47 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    36 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    102 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    32 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    59 Caffeine 1.5 mg/ml 4 hrs, larvae L3    108 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    80 Rotenone 2 μg 12 hrs, larvae L3    149 Rotenone 8 μg 12 hrs, larvae L3    158 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
External Data & Images
Linkouts	BDGP expression data • RH69586 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033518 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11765-RA;CG11765-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Prx2540-2 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Prx2540-2 Class Mutagen Stocks Known lesion Prx2540-2MB04531 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Prx2540-2 Class Mutagen Stocks Known lesion Prx2540-2GL00617 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Prx2540-2KK115925 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Prx2540-2NIG.11765R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7379} NA P{GD7718} NA P{GD7859} NA P{KK115925} NA P{NIG.11765R} NA P{TRiP.GL00617} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}KG02620 NA insertion of enhancer trap binary system Mi{ET1}Prx2540-2MB04531 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
thioredoxin peroxidase activity inferred from direct assay (Radyuk et al., 2001)
Biological Process
CV term Evidence References
hydrogen peroxide catabolic process inferred from direct assay (Radyuk et al., 2001)
Cellular Component
CV term Evidence References
cytosol inferred from direct assay (Radyuk et al., 2001)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
antioxidant activity inferred from sequence or structural similarity with UniProtKB:O77834 (FlyBase, 1992-) non-traceable author statement (Orr et al., 2001) glutathione peroxidase activity inferred from sequence or structural similarity with UniProtKB:O77834 (FlyBase, 1992-) peroxidase activity inferred from sequence or structural similarity with mouse Prdx6 (FlyBase, 1992-) non-traceable author statement (Orr et al., 2001)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR000866, InterPro:IPR019479 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Prx2540-2 - Akap200 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Ald experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - AnxB10 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Bacc experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG10638 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG11267 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG14715 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG14762 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG14968 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG16817 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG1910 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG2767 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG2852 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG2862 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG30339 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG31917 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG3226 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG34133 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG4278 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG4598 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG5355 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG5380 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG5382 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG5844 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Prx2540-2 - CG6084 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG7091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG7675 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - CG7911 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG8036 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG8993 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG9391 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - CG9705 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Chd64 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Crc experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - D1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - Der-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - Df31 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Eb1 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Eip55E experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - EndoGI experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Eno experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - FK506-bp2 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - FKBP59 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Fim experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Fkbp13 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Gdi experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - GstE6 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - GstO3 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - GstT1 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Hop experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Hsc70Cb experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Inos experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Jupiter experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Mdh2 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Moe experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Nacα experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Nlp experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Npc2g anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - Ntf-2 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Oat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - PHGPx experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Pdi experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Pgd experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Pgk experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Pglym78 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Proct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - Prosα1 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Prosα6 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Prosβ5 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Rab11 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - RhoGDI experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Sh3β experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - TER94 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Tal experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Trx-2 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Trxr-1 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - Uch experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - awd experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - capt experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - chic experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - cib experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - dUTPase experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - dj-1β experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - dod experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - eIF-5A experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - fabp experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - fbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Prx2540-2 - kdn experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - mus209 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - regucalcin experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - scf experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - scu experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - smt3 experimental knowledge based (Guruharsha et al., 2011) Prx2540-2 - yip2 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Prx2540-2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61917 DroID - A comprehensive database of gene and protein interactions. • FBgn0033518 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36098
Orthologs
OrthoDB Orthologs (59) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6DBV10 Dipteran inclusive ortholog search EOG69S6GD Insect inclusive ortholog search EOG6QFV9F Arthropod inclusive ortholog search EOG693216 Metazoa inclusive ortholog search EOG6MSRSZ
Orthologs in Drosophila Species (EOG6DBV10)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG12896     Drosophila melanogaster fruit fly  Dmel\Prx2540-2     Drosophila melanogaster fruit fly  Dmel\Prx2540-1     Drosophila simulans   Dsim\GD25985   Y Drosophila simulans   Dsim\GD25983   Y Drosophila sechellia   Dsec\GM20524   Y Drosophila sechellia   Dsec\GM21213   Y Drosophila sechellia   Dsec\GM21216   Y Drosophila erecta   Dere\GG24165   Y Drosophila erecta   Dere\GG25209   Y Drosophila yakuba   Dyak\GE19359   Y Drosophila ananassae   Dana\GF12795   Y Drosophila ananassae   Dana\GF12122   Y Drosophila ananassae   Dana\GF12124   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA11614   Y Drosophila persimilis   Dper\GL11593   Y Drosophila willistoni   Dwil\GK18009   Y Drosophila willistoni   Dwil\GK17795   Y Drosophila virilis   Dvir\GJ20147   Y Drosophila mojavensis   Dmoj\GI20198   Y Drosophila grimshawi   Dgri\GH20103   Y Drosophila grimshawi   Dgri\GH21252   Y Drosophila grimshawi   Dgri\GH20104   Y
Orthologs in non-Drosophila Dipterans (EOG69S6GD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002309 Y Anopheles gambiae Malaria mosquito  Agam\TPX4 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011296 Y
Orthologs in non-Dipteran Insects (EOG6QFV9F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Tpx-5 Y Apis mellifera Western honey bee  Amel\Tpx-4 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008049 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008816 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19448 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19347 Y Atta cephalotes Leafcutter ant  Acep\ACEP12494 Y Atta cephalotes Leafcutter ant  Acep\ACEP24636 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12925 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15279 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20275 Y Linepithema humile Argentine ant  Lhum\LH13284 Y Linepithema humile Argentine ant  Lhum\LH20706 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB16555 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB22401 Y Solenopsis invicta Red fire ant  Sinv\SINV12717 Y Solenopsis invicta Red fire ant  Sinv\SINV22015 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009972 Y Bombyx mori Silkmoth  Bmor\Prx Y Pediculus humanus Human body louse  Phum\PHUM316680 Y Pediculus humanus Human body louse  Phum\PHUM137490 Y Tribolium castaneum Red flour beetle  Tcas\TC004948 Y Tribolium castaneum Red flour beetle  Tcas\TC013791 Y
Orthologs in non-Insect Arthropods (EOG693216)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Ap5z1 Y
Orthologs in non-Arthropod Metazoa (EOG6MSRSZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\prdx-6 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013368gn Y Danio rerio Zebrafish  Drer\prdx6 Y Xenopus tropicalis Western clawed frog  Xtro\prdx6 Y Gallus gallus Domestic chicken  Ggal\PRDX6 Y Mus musculus House mouse  Mmus\Prdx6b Y Mus musculus House mouse  Mmus\Prdx6 Y Rattus norvegicus Norway rat  Rnor\Prdx6 Y Homo sapiens Human  Hsap\PRDX6 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\PRDX6
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	37474 y1 sc* v1; P{TRiP.GL00617}attP40 24813 w1118; Mi{ET1}CAPMB04531 Mi{ET1}Prx2540-2MB04531
Genomic Clones ( 1 )
	BACR20O22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 39 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD11278 RE05093 RE05501 RH69586
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE65973 RH44595 RH67414 SD05829 SD12071 SD14384 SD15788 SD16462 SD17422 SD19106 SD20682 SD23108 SD25471 SD25838 SD26440 SD26970
Other clones	522454 525010 bs56h06 bs73d10 EC13842 EN02046 EN06340 ESG019a.E21_B07 FGC013E10 FGM101A10 FGM223A10 FGM227E12 FGM229D11 RP001019041 RP001020551 RP001022507 RP001040414 RP001044425 RP001055050
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033518 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36098
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078959 RefSeq (Proteins) • NP_523683 DDBJ / EMBL / GenBank • AAF58799 AAG47824 AAL48574 AAM11306 AF311880 AY070952 AY094953 BI165247 BI604278 Entrez Gene - A searchable database of RefSeq genes. • 36098 UniProtKB/TrEMBL • Q7JX87 Q9GPQ0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant (IPR000866) Thioredoxin-like fold (IPR012336) Peroxiredoxin, C-terminal (IPR019479) Peroxiredoxin, AhpC-type (IPR024706) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH69586
Linkouts
	BioGRID - A database of protein and genetic interactions • 61917 DroID - A comprehensive database of gene and protein interactions. • FBgn0033518 DRSC - Results from RNAi screens. • FBgn0033518 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033518 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11765-RA;CG11765-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033518 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36098 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36098 modMine - Data generated by the modENCODE project. • FBgn0033518
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG11765 (Li et al., 2003, Lai et al., 2007, Herranz et al., 2012, Ni et al., 2011.7.19, Strub et al., 2008, Lebo et al., 2009, Xu et al., 2004, Ellis and Carney, 2010, Keleman et al., 2009.8.5, Cammarato et al., 2011, Girardot et al., 2004, Rand et al., 2008) DPx2540 (Orr et al., 2001) DPx-2540-2 (Radyuk, 2000.10.10, Radyuk et al., 2001) Prx2540 (Orr, 2001.3.5, Boyd et al., 2011, Sun et al., 2012) Prx2540-2 (Lai et al., 2007, Smith et al., 2011, Gilchrist et al., 2008, Ellis and Carney, 2010, Japanese National Institute of Genetics, 2012.5.21, Kalajdzic et al., 2012, Herz et al., 2012)
Name Synonym	Peroxiredoxin (Bozoky et al., 2009) peroxiredoxin 2540 (Xi et al., 2008) Peroxiredoxin 2540 (Orr et al., 2001, Lebo et al., 2009, Harbison et al., 2005, Cammarato et al., 2011, Sun et al., 2012) Peroxiredoxin 2540-2
Secondary FlyBase IDs
References ( 41 )
Generate a list of	All references relating to this gene ( 41 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 8 )
	Li et al., 2013, PLoS Genet. 9(1): e1003230 HIF- and Non-HIF-Regulated Hypoxic Responses Require the Estrogen-Related Receptor in Drosophila melanogaster. [FBrf0220675] Herranz et al., 2012, BMC Genomics 13: 52 Microgravity simulation by diamagnetic levitation: effects of a strong gradient magnetic field on the transcriptional profile of Drosophila melanogaster. [FBrf0217750] Herz et al., 2012, Mol. Cell. Biol. 32(9): 1683--1693 Polycomb repressive complex 2-dependent and -independent functions of jarid2 in transcriptional regulation in Drosophila. [FBrf0218000] Kalajdzic et al., 2012, PLoS ONE 7(6): e40296 Use of mutagenesis, genetic mapping and next generation transcriptomics to investigate insecticide resistance mechanisms. [FBrf0218826] Sebald et al., 2012, PLoS ONE 7(8): e43144 CHD1 Contributes to Intestinal Resistance against Infection by P. aeruginosa in Drosophila melanogaster. [FBrf0219215] Sun et al., 2012, Aging Cell 11(5): 783--793 Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. [FBrf0219634] Boyd et al., 2011, Free Radical Biol. Med. 50(11): 1669--1678 Nectarine promotes longevity in Drosophila melanogaster. [FBrf0213612] Smith et al., 2011, Mol. Cell 44(6): 954--965 The little elongation complex regulates small nuclear RNA transcription. [FBrf0217100] Show all research papers ...