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Gene Dmel\Elp2

General Information
Symbol	Dmel\Elp2	Species	D. melanogaster
Name	Elongator complex protein 2	Annotation symbol	CG11887
Feature type	protein_coding_gene	FlyBase ID	FBgn0033540
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	Stip
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	47B1-47B1	Sequence location	2R:6,533,230..6,536,139 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Elongator complex protein 2 is referred to in FlyBase by the symbol Dmel\Elp2 (CG11887, FBgn0033540). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: endopeptidase activator activity. Based on sequence similarity, it is predicted to be involved in the biological process: proteasome assembly; transcription elongation from RNA polymerase II promoter. 5 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Regulator of chromosome condensation, RCC1; WD40 repeat; WD40 repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1627110_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Elp2. Gene sequence location is 2R:6533230..6536139.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN20793 HFA06095
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 47B1-47B1
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Elp2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Elp2-RA FBtr0088212  NM_136756   2548   794
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Elp2-PA   FBpp0087307   89.0   794   5.32     NP_610600   AAF58765
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Regulator of chromosome condensation, RCC1 (IPR000408) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58765   AI134127   AI387738   AI515618   AI542255   AW943910   AY052019 AAK93443   BG632624   BI214303   BI356175   BI357496   BI362662   BI367856   BI638763   CO181474   CO276351   CO333424   CZ469899   CZ469936   EC239469   EC251254   EC253631   ES689760   ES690597   ES690611   ES690620   ES690623   ES690626   ES690630   GH742553   GH743313   GH762846   GH766036   GO254406
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033540    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033540 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033540 expression level Developmental Stage   Expression Level embryo 00-02hr    195 embryo 02-04hr    288 embryo 04-06hr    872 embryo 06-08hr    1005 embryo 08-10hr    1095 embryo 10-12hr    946 embryo 12-14hr    871 embryo 14-16hr    425 embryo 16-18hr    456 embryo 18-20hr    399 embryo 20-22hr    970 embryo 22-24hr    966 larva L1    1362 larva L2    891 larva L3 12hr old    631 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    485 larva L3 puffstage 7-9    564 white prepupae new    622 white prepupae 12hr    632 white prepupae 24hr    689 pupae 2d postWPP    625 pupae 3d postWPP    337 pupae 4d postWPP    390 adult male 01day    292 adult male 05day    353 adult male 30day    294 adult female 01day    602 adult female 05day    818 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (195) embryo 02-04hr  (288) embryo 04-06hr  (872) embryo 06-08hr  (1005) embryo 08-10hr  (1095) embryo 10-12hr  (946) embryo 12-14hr  (871) embryo 14-16hr  (425) embryo 16-18hr  (456) embryo 18-20hr  (399) embryo 20-22hr  (970) embryo 22-24hr  (966) larva L1  (1362) larva L2  (891) larva L3 12hr old  (631) larva L3 puffstage 1-2  (403) larva L3 puffstage 3-6  (485) larva L3 puffstage 7-9  (564) white prepupae new  (622) white prepupae 12hr  (632) white prepupae 24hr  (689) pupae 2d postWPP  (625) pupae 3d postWPP  (337) pupae 4d postWPP  (390) adult male 01day  (292) adult male 05day  (353) adult male 30day  (294) adult female 01day  (602) adult female 05day  (818) adult female 30day  (810) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    195 embryo 02-04hr    288 embryo 04-06hr    872 embryo 06-08hr    1005 embryo 08-10hr    1095 embryo 10-12hr    946 embryo 12-14hr    871 embryo 14-16hr    425 embryo 16-18hr    456 embryo 18-20hr    399 embryo 20-22hr    970 embryo 22-24hr    966 larva L1    1362 larva L2    891 larva L3 12hr old    631 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    485 larva L3 puffstage 7-9    564 white prepupae new    622 white prepupae 12hr    632 white prepupae 24hr    689 pupae 2d postWPP    625 pupae 3d postWPP    337 pupae 4d postWPP    390 adult male 01day    292 adult male 05day    353 adult male 30day    294 adult female 01day    602 adult female 05day    818 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    195 embryo 02-04hr    288 embryo 04-06hr    872 embryo 06-08hr    1005 embryo 08-10hr    1095 embryo 10-12hr    946 embryo 12-14hr    871 embryo 14-16hr    425 embryo 16-18hr    456 embryo 18-20hr    399 embryo 20-22hr    970 embryo 22-24hr    966 larva L1    1362 larva L2    891 larva L3 12hr old    631 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    485 larva L3 puffstage 7-9    564 white prepupae new    622 white prepupae 12hr    632 white prepupae 24hr    689 pupae 2d postWPP    625 pupae 3d postWPP    337 pupae 4d postWPP    390 adult male 01day    292 adult male 05day    353 adult male 30day    294 adult female 01day    602 adult female 05day    818 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    195 embryo 02-04hr    288 embryo 04-06hr    872 embryo 06-08hr    1005 embryo 08-10hr    1095 embryo 10-12hr    946 embryo 12-14hr    871 embryo 14-16hr    425 embryo 16-18hr    456 embryo 18-20hr    399 embryo 20-22hr    970 embryo 22-24hr    966 larva L1    1362 larva L2    891 larva L3 12hr old    631 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    485 larva L3 puffstage 7-9    564 white prepupae new    622 white prepupae 12hr    632 white prepupae 24hr    689 pupae 2d postWPP    625 pupae 3d postWPP    337 pupae 4d postWPP    390 adult male 01day    292 adult male 05day    353 adult male 30day    294 adult female 01day    602 adult female 05day    818 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033540 expression level Developmental Stage   Expression Level embryo 00-02hr    195 embryo 02-04hr    288 embryo 04-06hr    872 embryo 06-08hr    1005 embryo 08-10hr    1095 embryo 10-12hr    946 embryo 12-14hr    871 embryo 14-16hr    425 embryo 16-18hr    456 embryo 18-20hr    399 embryo 20-22hr    970 embryo 22-24hr    966 larva L1    1362 larva L2    891 larva L3 12hr old    631 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    485 larva L3 puffstage 7-9    564 white prepupae new    622 white prepupae 12hr    632 white prepupae 24hr    689 pupae 2d postWPP    625 pupae 3d postWPP    337 pupae 4d postWPP    390 adult male 01day    292 adult male 05day    353 adult male 30day    294 adult female 01day    602 adult female 05day    818 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (195) embryo 02-04hr  (288) embryo 04-06hr  (872) embryo 06-08hr  (1005) embryo 08-10hr  (1095) embryo 10-12hr  (946) embryo 12-14hr  (871) embryo 14-16hr  (425) embryo 16-18hr  (456) embryo 18-20hr  (399) embryo 20-22hr  (970) embryo 22-24hr  (966) larva L1  (1362) larva L2  (891) larva L3 12hr old  (631) larva L3 puffstage 1-2  (403) larva L3 puffstage 3-6  (485) larva L3 puffstage 7-9  (564) white prepupae new  (622) white prepupae 12hr  (632) white prepupae 24hr  (689) pupae 2d postWPP  (625) pupae 3d postWPP  (337) pupae 4d postWPP  (390) adult male 01day  (292) adult male 05day  (353) adult male 30day  (294) adult female 01day  (602) adult female 05day  (818) adult female 30day  (810) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    195 embryo 02-04hr    288 embryo 04-06hr    872 embryo 06-08hr    1005 embryo 08-10hr    1095 embryo 10-12hr    946 embryo 12-14hr    871 embryo 14-16hr    425 embryo 16-18hr    456 embryo 18-20hr    399 embryo 20-22hr    970 embryo 22-24hr    966 larva L1    1362 larva L2    891 larva L3 12hr old    631 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    485 larva L3 puffstage 7-9    564 white prepupae new    622 white prepupae 12hr    632 white prepupae 24hr    689 pupae 2d postWPP    625 pupae 3d postWPP    337 pupae 4d postWPP    390 adult male 01day    292 adult male 05day    353 adult male 30day    294 adult female 01day    602 adult female 05day    818 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    195 embryo 02-04hr    288 embryo 04-06hr    872 embryo 06-08hr    1005 embryo 08-10hr    1095 embryo 10-12hr    946 embryo 12-14hr    871 embryo 14-16hr    425 embryo 16-18hr    456 embryo 18-20hr    399 embryo 20-22hr    970 embryo 22-24hr    966 larva L1    1362 larva L2    891 larva L3 12hr old    631 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    485 larva L3 puffstage 7-9    564 white prepupae new    622 white prepupae 12hr    632 white prepupae 24hr    689 pupae 2d postWPP    625 pupae 3d postWPP    337 pupae 4d postWPP    390 adult male 01day    292 adult male 05day    353 adult male 30day    294 adult female 01day    602 adult female 05day    818 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    195 embryo 02-04hr    288 embryo 04-06hr    872 embryo 06-08hr    1005 embryo 08-10hr    1095 embryo 10-12hr    946 embryo 12-14hr    871 embryo 14-16hr    425 embryo 16-18hr    456 embryo 18-20hr    399 embryo 20-22hr    970 embryo 22-24hr    966 larva L1    1362 larva L2    891 larva L3 12hr old    631 larva L3 puffstage 1-2    403 larva L3 puffstage 3-6    485 larva L3 puffstage 7-9    564 white prepupae new    622 white prepupae 12hr    632 white prepupae 24hr    689 pupae 2d postWPP    625 pupae 3d postWPP    337 pupae 4d postWPP    390 adult male 01day    292 adult male 05day    353 adult male 30day    294 adult female 01day    602 adult female 05day    818 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033540    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033540 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033540 expression level Tissue   Expression Level Larval Central Nervous System    104.425 Larval Midgut    54.4 Larval Hindgut    78.5 Larval Malpighian Tubules    37.1 Larval Fat Body    48.2 Larval Salivary Gland    126.1 Larval Trachea    73.6 Larval Carcass    123.85 Adult Head    44.5 Adult Eye    35.575 Adult Brain    48.7 Adult Thoracic-Abdominal Ganglion    49.2 Adult Crop    72.8 Adult Midgut    60.9 Adult Hindgut    57.4 Adult Malpighian Tubules    62.1 Adult Fat Body    89.3 Adult Salivary Gland    77 Adult Heart    47.025 Adult VirginFemale Spermatheca    74.8 Adult InseminatedFemale Spermatheca    85.3 Adult Ovary    83 Adult Testis    39.4 Adult Male Accessory Gland    136.8 Adult Carcass    51.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    104.425 Larval Midgut    54.4 Larval Hindgut    78.5 Larval Malpighian Tubules    37.1 Larval Fat Body    48.2 Larval Salivary Gland    126.1 Larval Trachea    73.6 Larval Carcass    123.85 Adult Head    44.5 Adult Eye    35.575 Adult Brain    48.7 Adult Thoracic-Abdominal Ganglion    49.2 Adult Crop    72.8 Adult Midgut    60.9 Adult Hindgut    57.4 Adult Malpighian Tubules    62.1 Adult Fat Body    89.3 Adult Salivary Gland    77 Adult Heart    47.025 Adult VirginFemale Spermatheca    74.8 Adult InseminatedFemale Spermatheca    85.3 Adult Ovary    83 Adult Testis    39.4 Adult Male Accessory Gland    136.8 Adult Carcass    51.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    104.425 Larval Midgut    54.4 Larval Hindgut    78.5 Larval Malpighian Tubules    37.1 Larval Fat Body    48.2 Larval Salivary Gland    126.1 Larval Trachea    73.6 Larval Carcass    123.85 Adult Head    44.5 Adult Eye    35.575 Adult Brain    48.7 Adult Thoracic-Abdominal Ganglion    49.2 Adult Crop    72.8 Adult Midgut    60.9 Adult Hindgut    57.4 Adult Malpighian Tubules    62.1 Adult Fat Body    89.3 Adult Salivary Gland    77 Adult Heart    47.025 Adult VirginFemale Spermatheca    74.8 Adult InseminatedFemale Spermatheca    85.3 Adult Ovary    83 Adult Testis    39.4 Adult Male Accessory Gland    136.8 Adult Carcass    51.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    104.425 Larval Midgut    54.4 Larval Hindgut    78.5 Larval Malpighian Tubules    37.1 Larval Fat Body    48.2 Larval Salivary Gland    126.1 Larval Trachea    73.6 Larval Carcass    123.85 Adult Head    44.5 Adult Eye    35.575 Adult Brain    48.7 Adult Thoracic-Abdominal Ganglion    49.2 Adult Crop    72.8 Adult Midgut    60.9 Adult Hindgut    57.4 Adult Malpighian Tubules    62.1 Adult Fat Body    89.3 Adult Salivary Gland    77 Adult Heart    47.025 Adult VirginFemale Spermatheca    74.8 Adult InseminatedFemale Spermatheca    85.3 Adult Ovary    83 Adult Testis    39.4 Adult Male Accessory Gland    136.8 Adult Carcass    51.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033540 expression level Tissue   Expression Level Larval Central Nervous System    104.425 Larval Midgut    54.4 Larval Hindgut    78.5 Larval Malpighian Tubules    37.1 Larval Fat Body    48.2 Larval Salivary Gland    126.1 Larval Trachea    73.6 Larval Carcass    123.85 Adult Head    44.5 Adult Eye    35.575 Adult Brain    48.7 Adult Thoracic-Abdominal Ganglion    49.2 Adult Crop    72.8 Adult Midgut    60.9 Adult Hindgut    57.4 Adult Malpighian Tubules    62.1 Adult Fat Body    89.3 Adult Salivary Gland    77 Adult Heart    47.025 Adult VirginFemale Spermatheca    74.8 Adult InseminatedFemale Spermatheca    85.3 Adult Ovary    83 Adult Testis    39.4 Adult Male Accessory Gland    136.8 Adult Carcass    51.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    104.425 Larval Midgut    54.4 Larval Hindgut    78.5 Larval Malpighian Tubules    37.1 Larval Fat Body    48.2 Larval Salivary Gland    126.1 Larval Trachea    73.6 Larval Carcass    123.85 Adult Head    44.5 Adult Eye    35.575 Adult Brain    48.7 Adult Thoracic-Abdominal Ganglion    49.2 Adult Crop    72.8 Adult Midgut    60.9 Adult Hindgut    57.4 Adult Malpighian Tubules    62.1 Adult Fat Body    89.3 Adult Salivary Gland    77 Adult Heart    47.025 Adult VirginFemale Spermatheca    74.8 Adult InseminatedFemale Spermatheca    85.3 Adult Ovary    83 Adult Testis    39.4 Adult Male Accessory Gland    136.8 Adult Carcass    51.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    104.425 Larval Midgut    54.4 Larval Hindgut    78.5 Larval Malpighian Tubules    37.1 Larval Fat Body    48.2 Larval Salivary Gland    126.1 Larval Trachea    73.6 Larval Carcass    123.85 Adult Head    44.5 Adult Eye    35.575 Adult Brain    48.7 Adult Thoracic-Abdominal Ganglion    49.2 Adult Crop    72.8 Adult Midgut    60.9 Adult Hindgut    57.4 Adult Malpighian Tubules    62.1 Adult Fat Body    89.3 Adult Salivary Gland    77 Adult Heart    47.025 Adult VirginFemale Spermatheca    74.8 Adult InseminatedFemale Spermatheca    85.3 Adult Ovary    83 Adult Testis    39.4 Adult Male Accessory Gland    136.8 Adult Carcass    51.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    104.425 Larval Midgut    54.4 Larval Hindgut    78.5 Larval Malpighian Tubules    37.1 Larval Fat Body    48.2 Larval Salivary Gland    126.1 Larval Trachea    73.6 Larval Carcass    123.85 Adult Head    44.5 Adult Eye    35.575 Adult Brain    48.7 Adult Thoracic-Abdominal Ganglion    49.2 Adult Crop    72.8 Adult Midgut    60.9 Adult Hindgut    57.4 Adult Malpighian Tubules    62.1 Adult Fat Body    89.3 Adult Salivary Gland    77 Adult Heart    47.025 Adult VirginFemale Spermatheca    74.8 Adult InseminatedFemale Spermatheca    85.3 Adult Ovary    83 Adult Testis    39.4 Adult Male Accessory Gland    136.8 Adult Carcass    51.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    44.5   NA  Eye    35.575   NA  Brain    48.7   104.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    49.2   NA  Crop    72.8   54.4  Midgut    60.9   78.5  Hindgut    57.4   37.1  Malpighian Tubules    62.1   48.2  Fat Body    89.3   126.1  Salivary Gland    77   NA  Heart    47.025   73.6  Trachea    NA   NA  VirginFemale Spermatheca    74.8   NA  InseminatedFemale Spermatheca    85.3   NA  Ovary    83   NA  Testis    39.4   NA  Male Accessory Gland    136.8   123.85  Carcass    51.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033540 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11887-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Elp2 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Elp2GD6738 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Elp2GD6738 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 Elp2GD6738
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Elp2 Class Mutagen Stocks Known lesion Elp2c05390 piggyBac transposase 1 -- Elp2c02284 0 -- Elp2c05343 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Elp2 Class Mutagen Stocks Known lesion Elp2GD6738 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Elp2KK100697 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}Elp2c02284 NA PBac{PB}Elp2c05343 NA PBac{PB}Elp2c05390 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
endopeptidase activator activity inferred from sequence or structural similarity with UniProtKB:Q16186 (assigned by UniProtKB) (FBrf0198885)
Biological Process
CV term Evidence References
proteasome assembly inferred from sequence or structural similarity with UniProtKB:Q16186 (assigned by UniProtKB) (FBrf0198885) transcription elongation from RNA polymerase II promoter inferred from sequence or structural similarity with UniProtKB:Q16186 (assigned by UniProtKB) (FBrf0198885)
Cellular Component
CV term Evidence References
proteasome complex inferred from sequence or structural similarity with UniProtKB:Q16186 (assigned by UniProtKB) (FBrf0198885)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Elp2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61932 DroID - A comprehensive database of gene and protein interactions. • FBgn0033540 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36123
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13770 Dere\GG20140 Dgri\GH21263 Dmoj\GI19340 Dper\GL17299 Dpse\GA11261 Dsec\GM21226 Dsim\GD10748 Dvir\GJ22219 Dwil\GK19482 Dyak\GE12828
Curated drosophilid orthologs	Dpse\GA11261
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004896-PA Aedes aegypti (mosquito) AGAP006889-PA Anopheles gambiae (mosquito) XP_396388.3 Apis mellifera (honey bee) XP_001949746.1 Acyrthosiphon pisum (pea aphid) At1g49540.1 Arabidopsis thaliana (wall cress) 36146 Batrachochytrium dendrobatidis (chytrid fungus) 206700 Branchiostoma floridae (lancelet) XP_001895165.1 Brugia malayi (roundworm nematode) ENSBTAP00000025227 Bos taurus (bovine) CAL0004181 Candida albicans (a form of yeast) CN11675 Caenorhabditis brenneri (small nematode) CBP27971 Caenorhabditis briggsae (nematode) CE34502 Caenorhabditis elegans (worm) ENSCAFP00000026340 Canis familiaris (dog) CAGL0K00957g Candida glabrata (haploid yeast) ENSCINP00000018483 Ciona intestinalis (sea squirt) JA04565 Caenorhabditis japonica (nematode) CMS119C Cyanidioschyzon merolae (red alga) cn02149 Cryptococcus neoformans (yeast-like fungus) CPIJ014207 Culex pipens (mosquito) ENSCPOP00000005068 Cavia porcellus (guinea pig) RP44197 Caenorhabditis remanei (nematode) ENSCSAVP00000001502 Ciona savignyi (sedentary tunicate) 179061 Capitella spl (polychaete worm) DDB0231759 Dictyostelium discoideum (amoeba) DEHA2B03278g Debaryomyces Hansenii (yeast) 309080 Daphnia pulex (daphnia) ENSDARP00000039748 Danio rerio (zebra fish) ENSECAP00000008385 Equus caballus (horse) ENSGACP00000007826 Gymnopilus aculeatus (mushroom) ENSGALP00000021535 Gallus gallus (chicken) 105279 Hypsipyla robusta (cedar shoot borer) ENSP00000350967 Homo sapiens (human) ISCW020327-PA Ixodes scapularis (deer tick) KLLA0F22000g Kluyveromyces lactis (yeast) 207709 Lottia gigantea (owl limpet) 31734 Monocosta brevicollis (choanoflagellate) ENSMODP00000000519 Monodelphis domestica (gray opossum) ENSMMUP00000024732 Macaca mulatta (rhesus monkey) ENSMUSP00000025120 Mus musculus (house mouse) XP_001599852.1 Nasonia vitripennis (wasp) ENSOANP00000016103 Ornithorynchus anatinus (platypus) ENSORLP00000004281 Oryzias latipes (japanese killifish) LOC_Os08g38570.1 Oryza sativa (asian rice) 701 Ostreococcus tauri (green alga) PHUM011053-PA Pediculus humanus (human body louse) 153828 Physcomitrella patens (moss) ENSPPYP00000010234 Pongo pygmaeus (orangutan) 142085 Phytophthora sojae (root rot pathogen) ENSPTRP00000040690 Pan troglodytes (chimpanzee) ENSRNOP00000020601 Rattus norvegicus (norway rat) 5008255 Sorghum bicolor (sorghum) YGR200C Saccharomyces cerevisiae (budding yeast) Smp_050730 Schistosoma mansoni (trematode parasite) SPCC895.06 Schizosaccharomyces pombe (fission yeast) XP_001183960.1 Strongylocentrotus purpuratus (purple sea urchin) 55003 Trichoplax adhaerens (metazoa) XP_974342.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005717 Tetraodon nigroviridis (green spotted pufferfish) 25824 Thalassiosira pseudonana (marine diatom) ENSTRUP00000027989 Takifugu rubripes (pufferfish Takifugu) 3810.m01836 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000041059 Xenopus tropicalis (frog) YALI0C23386g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV19147 LH16514 ISCW020327 FBgn0230548 FBgn0221480 FBgn0209332 FBgn0182512 FBgn0176107 JGI_V11_309080 FBgn0071315 FBgn0154902 FBgn0142078 FBgn0128725 FBgn0112334 FBgn0090797 CPIJ014207 BGIBMGA002831 ACYPI000542 GB17705 AGAP006889 AAEL004896 PB22850 PHUM573890 GLEAN_12601
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Harvard	- PBac{PB}Elp2c05390
VDRC	v105393 P{KK100697}VIE-260B v17560 w1118; P{GD6738}v17560
Genomic Clones ( 2 )
	BACR08L17 BACR31I21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD47515
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH18377 RE20070 RE42259 RE44006 RE47279 RE53717 SD08460 SD21135
Other clones	192602 214575.26 281623 EC14385 EK120603 EK306915 GH11494 RP01277 RP001012103 RP001012217 RP001016964 RP001026687
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033540 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36123
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Elp2 StIP (Lipardi and Paterson, 2009) Source for identity of: StIP CG11887 (Han and Harrison, 2006)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136756 RefSeq (Proteins) • NP_610600 DDBJ / EMBL / GenBank • AAF58765 AAF58765.2 AAK93443 AI515618 AW943910 AY052019 CZ469899 CZ469936 Entrez Gene - A searchable database of RefSeq genes. • 36123
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Regulator of chromosome condensation, RCC1 (IPR000408) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61932 DroID - A comprehensive database of gene and protein interactions. • FBgn0033540 DRSC - Results from RNAi screens. • FBgn0033540 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033540 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11887-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033540 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36123 InParanoid A subset of ortholog calls from InParanoid. • AAEL004896-PA Aedes aegypti (mosquito) AGAP006889-PA Anopheles gambiae (mosquito) XP_396388.3 Apis mellifera (honey bee) XP_001949746.1 Acyrthosiphon pisum (pea aphid) At1g49540.1 Arabidopsis thaliana (wall cress) 36146 Batrachochytrium dendrobatidis (chytrid fungus) 206700 Branchiostoma floridae (lancelet) XP_001895165.1 Brugia malayi (roundworm nematode) ENSBTAP00000025227 Bos taurus (bovine) CAL0004181 Candida albicans (a form of yeast) CN11675 Caenorhabditis brenneri (small nematode) CBP27971 Caenorhabditis briggsae (nematode) CE34502 Caenorhabditis elegans (worm) ENSCAFP00000026340 Canis familiaris (dog) CAGL0K00957g Candida glabrata (haploid yeast) ENSCINP00000018483 Ciona intestinalis (sea squirt) JA04565 Caenorhabditis japonica (nematode) CMS119C Cyanidioschyzon merolae (red alga) cn02149 Cryptococcus neoformans (yeast-like fungus) CPIJ014207 Culex pipens (mosquito) ENSCPOP00000005068 Cavia porcellus (guinea pig) RP44197 Caenorhabditis remanei (nematode) ENSCSAVP00000001502 Ciona savignyi (sedentary tunicate) 179061 Capitella spl (polychaete worm) DDB0231759 Dictyostelium discoideum (amoeba) DEHA2B03278g Debaryomyces Hansenii (yeast) 309080 Daphnia pulex (daphnia) ENSDARP00000039748 Danio rerio (zebra fish) ENSECAP00000008385 Equus caballus (horse) ENSGACP00000007826 Gymnopilus aculeatus (mushroom) ENSGALP00000021535 Gallus gallus (chicken) 105279 Hypsipyla robusta (cedar shoot borer) ENSP00000350967 Homo sapiens (human) ISCW020327-PA Ixodes scapularis (deer tick) KLLA0F22000g Kluyveromyces lactis (yeast) 207709 Lottia gigantea (owl limpet) 31734 Monocosta brevicollis (choanoflagellate) ENSMODP00000000519 Monodelphis domestica (gray opossum) ENSMMUP00000024732 Macaca mulatta (rhesus monkey) ENSMUSP00000025120 Mus musculus (house mouse) XP_001599852.1 Nasonia vitripennis (wasp) ENSOANP00000016103 Ornithorynchus anatinus (platypus) ENSORLP00000004281 Oryzias latipes (japanese killifish) LOC_Os08g38570.1 Oryza sativa (asian rice) 701 Ostreococcus tauri (green alga) PHUM011053-PA Pediculus humanus (human body louse) 153828 Physcomitrella patens (moss) ENSPPYP00000010234 Pongo pygmaeus (orangutan) 142085 Phytophthora sojae (root rot pathogen) ENSPTRP00000040690 Pan troglodytes (chimpanzee) ENSRNOP00000020601 Rattus norvegicus (norway rat) 5008255 Sorghum bicolor (sorghum) YGR200C Saccharomyces cerevisiae (budding yeast) Smp_050730 Schistosoma mansoni (trematode parasite) SPCC895.06 Schizosaccharomyces pombe (fission yeast) XP_001183960.1 Strongylocentrotus purpuratus (purple sea urchin) 55003 Trichoplax adhaerens (metazoa) XP_974342.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005717 Tetraodon nigroviridis (green spotted pufferfish) 25824 Thalassiosira pseudonana (marine diatom) ENSTRUP00000027989 Takifugu rubripes (pufferfish Takifugu) 3810.m01836 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000041059 Xenopus tropicalis (frog) YALI0C23386g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36123 modMine - Data generated by the modENCODE project. • FBgn0033540 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV19147 LH16514 ISCW020327 FBgn0230548 FBgn0221480 FBgn0209332 FBgn0182512 FBgn0176107 JGI_V11_309080 FBgn0071315 FBgn0154902 FBgn0142078 FBgn0128725 FBgn0112334 FBgn0090797 CPIJ014207 BGIBMGA002831 ACYPI000542 GB17705 AGAP006889 AAEL004896 PB22850 PHUM573890 GLEAN_12601
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG1187 (Han and Harrison, 2006) CG11887 (Han and Harrison, 2006, Han and Harrison, 2007, Han and Harrison, 2008, Keleman et al., 2009.8.5, Lipardi and Paterson, 2009) D-elp2 (Lipardi and Paterson, 2009) elp-2 (Lipardi and Paterson, 2009) Elp2   Stip (Han and Harrison, 2008) StIP (Han and Harrison, 2007, FBrf0198885, Han and Harrison, 2008)
Name Synonym	Elongator complex protein 2   StIP
Secondary FlyBase IDs
References ( 17 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Lipardi and Paterson, 2009, Proc. Natl. Acad. Sci. U.S.A. 106(37): 15645--15650 Identification of an RNA-dependent RNA polymerase in Drosophila involved in RNAi and transposon suppression. [FBrf0209161]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
Abstract	Han and Harrison, 2008, A. Dros. Res. Conf. 49: 353B The function of StIP in the JAK/STAT pathway. [FBrf0203820] Han and Harrison, 2007, A. Dros. Res. Conf. 48: 442A The function of StIP in the JAK/STAT pathway. [FBrf0198212] Han and Harrison, 2006, A. Dros. Res. Conf. 47: 380A The function of StIP in the JAK/STAT pathway. [FBrf0189403]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Protein sequence record	Putative elongator complex protein 2 (ELP2) (Stat3-interacting protein homolog). [FBrf0198885]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]