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Gene Dmel\CG12343

General Information
Symbol	Dmel\CG12343	Species	D. melanogaster
Name		Annotation symbol	CG12343
Feature type	protein_coding_gene	FlyBase ID	FBgn0033556
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	47C1-47C1	Sequence location	2R:6,709,743..6,710,826 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG12343 (FBgn0033556). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: neurogenesis. 3 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: mRNA splicing factor SYF2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634281_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG12343. Gene sequence location is 2R:6709743..6710826.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA06135 BKN21895 Controlled Vocabulary Terms neurogenesis
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 47C1-47C1   Limits computationally determined from genome sequence between P{lacW}l(2)k00909k00909&P{EP}EP2619EP2619 and P{lacW}l(2)k15826k15826&P{EP}EP471
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG12343 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG12343-RA FBtr0088247  NM_136773   1084   226
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG12343-PA   FBpp0087342   26.5   226   10.18     NP_610617   AAF58745
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • mRNA splicing factor SYF2 (IPR013260)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58745   BT022631   CL527776   CO189679   CO307356   EC057018   EC226473   EC229860   GH740318   GH743403   GH743623   GH745737   GH761917   GH765154   GH767194   GH767630   GH767682   GH779671   GH779821
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V5Q4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033556    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033556 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033556 expression level Developmental Stage   Expression Level embryo 00-02hr    2381 embryo 02-04hr    3774 embryo 04-06hr    3883 embryo 06-08hr    3419 embryo 08-10hr    3400 embryo 10-12hr    3736 embryo 12-14hr    2610 embryo 14-16hr    1200 embryo 16-18hr    1716 embryo 18-20hr    1581 embryo 20-22hr    2207 embryo 22-24hr    2216 larva L1    699 larva L2    944 larva L3 12hr old    665 larva L3 puffstage 1-2    856 larva L3 puffstage 3-6    1438 larva L3 puffstage 7-9    1916 white prepupae new    1915 white prepupae 12hr    1825 white prepupae 24hr    1942 pupae 2d postWPP    2051 pupae 3d postWPP    1346 pupae 4d postWPP    723 adult male 01day    1507 adult male 05day    1944 adult male 30day    1200 adult female 01day    695 adult female 05day    1606 adult female 30day    1684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2381) embryo 02-04hr  (3774) embryo 04-06hr  (3883) embryo 06-08hr  (3419) embryo 08-10hr  (3400) embryo 10-12hr  (3736) embryo 12-14hr  (2610) embryo 14-16hr  (1200) embryo 16-18hr  (1716) embryo 18-20hr  (1581) embryo 20-22hr  (2207) embryo 22-24hr  (2216) larva L1  (699) larva L2  (944) larva L3 12hr old  (665) larva L3 puffstage 1-2  (856) larva L3 puffstage 3-6  (1438) larva L3 puffstage 7-9  (1916) white prepupae new  (1915) white prepupae 12hr  (1825) white prepupae 24hr  (1942) pupae 2d postWPP  (2051) pupae 3d postWPP  (1346) pupae 4d postWPP  (723) adult male 01day  (1507) adult male 05day  (1944) adult male 30day  (1200) adult female 01day  (695) adult female 05day  (1606) adult female 30day  (1684) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2381) embryo 02-04hr  (3774) embryo 04-06hr  (3883) embryo 06-08hr  (3419) embryo 08-10hr  (3400) embryo 10-12hr  (3736) embryo 12-14hr  (2610) embryo 14-16hr    1200 embryo 16-18hr  (1716) embryo 18-20hr  (1581) embryo 20-22hr  (2207) embryo 22-24hr  (2216) larva L1    699 larva L2    944 larva L3 12hr old    665 larva L3 puffstage 1-2    856 larva L3 puffstage 3-6  1438 larva L3 puffstage 7-9  (1916) white prepupae new  (1915) white prepupae 12hr  (1825) white prepupae 24hr  (1942) pupae 2d postWPP  (2051) pupae 3d postWPP    1346 pupae 4d postWPP    723 adult male 01day  1507 adult male 05day  (1944) adult male 30day    1200 adult female 01day    695 adult female 05day  (1606) adult female 30day  (1684) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2381 embryo 02-04hr    3774 embryo 04-06hr    3883 embryo 06-08hr    3419 embryo 08-10hr    3400 embryo 10-12hr    3736 embryo 12-14hr    2610 embryo 14-16hr    1200 embryo 16-18hr    1716 embryo 18-20hr    1581 embryo 20-22hr    2207 embryo 22-24hr    2216 larva L1    699 larva L2    944 larva L3 12hr old    665 larva L3 puffstage 1-2    856 larva L3 puffstage 3-6    1438 larva L3 puffstage 7-9    1916 white prepupae new    1915 white prepupae 12hr    1825 white prepupae 24hr    1942 pupae 2d postWPP    2051 pupae 3d postWPP    1346 pupae 4d postWPP    723 adult male 01day    1507 adult male 05day    1944 adult male 30day    1200 adult female 01day    695 adult female 05day    1606 adult female 30day    1684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2381 embryo 02-04hr    3774 embryo 04-06hr    3883 embryo 06-08hr    3419 embryo 08-10hr    3400 embryo 10-12hr    3736 embryo 12-14hr    2610 embryo 14-16hr    1200 embryo 16-18hr    1716 embryo 18-20hr    1581 embryo 20-22hr    2207 embryo 22-24hr    2216 larva L1    699 larva L2    944 larva L3 12hr old    665 larva L3 puffstage 1-2    856 larva L3 puffstage 3-6    1438 larva L3 puffstage 7-9    1916 white prepupae new    1915 white prepupae 12hr    1825 white prepupae 24hr    1942 pupae 2d postWPP    2051 pupae 3d postWPP    1346 pupae 4d postWPP    723 adult male 01day    1507 adult male 05day    1944 adult male 30day    1200 adult female 01day    695 adult female 05day    1606 adult female 30day    1684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033556 expression level Developmental Stage   Expression Level embryo 00-02hr    2381 embryo 02-04hr    3774 embryo 04-06hr    3883 embryo 06-08hr    3419 embryo 08-10hr    3400 embryo 10-12hr    3736 embryo 12-14hr    2610 embryo 14-16hr    1200 embryo 16-18hr    1716 embryo 18-20hr    1581 embryo 20-22hr    2207 embryo 22-24hr    2216 larva L1    699 larva L2    944 larva L3 12hr old    665 larva L3 puffstage 1-2    856 larva L3 puffstage 3-6    1438 larva L3 puffstage 7-9    1916 white prepupae new    1915 white prepupae 12hr    1825 white prepupae 24hr    1942 pupae 2d postWPP    2051 pupae 3d postWPP    1346 pupae 4d postWPP    723 adult male 01day    1507 adult male 05day    1944 adult male 30day    1200 adult female 01day    695 adult female 05day    1606 adult female 30day    1684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2381) embryo 02-04hr  (3774) embryo 04-06hr  (3883) embryo 06-08hr  (3419) embryo 08-10hr  (3400) embryo 10-12hr  (3736) embryo 12-14hr  (2610) embryo 14-16hr  (1200) embryo 16-18hr  (1716) embryo 18-20hr  (1581) embryo 20-22hr  (2207) embryo 22-24hr  (2216) larva L1  (699) larva L2  (944) larva L3 12hr old  (665) larva L3 puffstage 1-2  (856) larva L3 puffstage 3-6  (1438) larva L3 puffstage 7-9  (1916) white prepupae new  (1915) white prepupae 12hr  (1825) white prepupae 24hr  (1942) pupae 2d postWPP  (2051) pupae 3d postWPP  (1346) pupae 4d postWPP  (723) adult male 01day  (1507) adult male 05day  (1944) adult male 30day  (1200) adult female 01day  (695) adult female 05day  (1606) adult female 30day  (1684) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2381 embryo 02-04hr  (3774) embryo 04-06hr  (3883) embryo 06-08hr  (3419) embryo 08-10hr  (3400) embryo 10-12hr  (3736) embryo 12-14hr  (2610) embryo 14-16hr    1200 embryo 16-18hr  1716 embryo 18-20hr  1581 embryo 20-22hr  2207 embryo 22-24hr  2216 larva L1    699 larva L2    944 larva L3 12hr old    665 larva L3 puffstage 1-2    856 larva L3 puffstage 3-6  1438 larva L3 puffstage 7-9  1916 white prepupae new  1915 white prepupae 12hr  1825 white prepupae 24hr  1942 pupae 2d postWPP  2051 pupae 3d postWPP    1346 pupae 4d postWPP    723 adult male 01day  1507 adult male 05day  1944 adult male 30day    1200 adult female 01day    695 adult female 05day  1606 adult female 30day  1684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2381 embryo 02-04hr    3774 embryo 04-06hr    3883 embryo 06-08hr    3419 embryo 08-10hr    3400 embryo 10-12hr    3736 embryo 12-14hr    2610 embryo 14-16hr    1200 embryo 16-18hr    1716 embryo 18-20hr    1581 embryo 20-22hr    2207 embryo 22-24hr    2216 larva L1    699 larva L2    944 larva L3 12hr old    665 larva L3 puffstage 1-2    856 larva L3 puffstage 3-6    1438 larva L3 puffstage 7-9    1916 white prepupae new    1915 white prepupae 12hr    1825 white prepupae 24hr    1942 pupae 2d postWPP    2051 pupae 3d postWPP    1346 pupae 4d postWPP    723 adult male 01day    1507 adult male 05day    1944 adult male 30day    1200 adult female 01day    695 adult female 05day    1606 adult female 30day    1684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2381 embryo 02-04hr    3774 embryo 04-06hr    3883 embryo 06-08hr    3419 embryo 08-10hr    3400 embryo 10-12hr    3736 embryo 12-14hr    2610 embryo 14-16hr    1200 embryo 16-18hr    1716 embryo 18-20hr    1581 embryo 20-22hr    2207 embryo 22-24hr    2216 larva L1    699 larva L2    944 larva L3 12hr old    665 larva L3 puffstage 1-2    856 larva L3 puffstage 3-6    1438 larva L3 puffstage 7-9    1916 white prepupae new    1915 white prepupae 12hr    1825 white prepupae 24hr    1942 pupae 2d postWPP    2051 pupae 3d postWPP    1346 pupae 4d postWPP    723 adult male 01day    1507 adult male 05day    1944 adult male 30day    1200 adult female 01day    695 adult female 05day    1606 adult female 30day    1684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033556    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033556 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033556 expression level Tissue   Expression Level Larval Central Nervous System    230.8 Larval Midgut    89.6 Larval Hindgut    136.5 Larval Malpighian Tubules    325.5 Larval Fat Body    198.7 Larval Salivary Gland    127.8 Larval Trachea    283.425 Larval Carcass    108.725 Adult Head    213.9 Adult Eye    370.7 Adult Brain    238.8 Adult Thoracic-Abdominal Ganglion    182.8 Adult Crop    352.3 Adult Midgut    157.1 Adult Hindgut    198.6 Adult Malpighian Tubules    326.5 Adult Fat Body    139.9 Adult Salivary Gland    188.7 Adult Heart    202.225 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    324.6 Adult Ovary    283.5 Adult Testis    321.1 Adult Male Accessory Gland    207.7 Adult Carcass    174.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    230.8 Larval Midgut    89.6 Larval Hindgut    136.5 Larval Malpighian Tubules    325.5 Larval Fat Body    198.7 Larval Salivary Gland    127.8 Larval Trachea    283.425 Larval Carcass    108.725 Adult Head    213.9 Adult Eye    370.7 Adult Brain    238.8 Adult Thoracic-Abdominal Ganglion    182.8 Adult Crop    352.3 Adult Midgut    157.1 Adult Hindgut    198.6 Adult Malpighian Tubules    326.5 Adult Fat Body    139.9 Adult Salivary Gland    188.7 Adult Heart    202.225 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    324.6 Adult Ovary    283.5 Adult Testis    321.1 Adult Male Accessory Gland    207.7 Adult Carcass    174.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    230.8 Larval Midgut    89.6 Larval Hindgut    136.5 Larval Malpighian Tubules    325.5 Larval Fat Body    198.7 Larval Salivary Gland    127.8 Larval Trachea    283.425 Larval Carcass    108.725 Adult Head    213.9 Adult Eye    370.7 Adult Brain    238.8 Adult Thoracic-Abdominal Ganglion    182.8 Adult Crop    352.3 Adult Midgut    157.1 Adult Hindgut    198.6 Adult Malpighian Tubules    326.5 Adult Fat Body    139.9 Adult Salivary Gland    188.7 Adult Heart    202.225 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    324.6 Adult Ovary    283.5 Adult Testis    321.1 Adult Male Accessory Gland    207.7 Adult Carcass    174.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    230.8 Larval Midgut    89.6 Larval Hindgut    136.5 Larval Malpighian Tubules    325.5 Larval Fat Body    198.7 Larval Salivary Gland    127.8 Larval Trachea    283.425 Larval Carcass    108.725 Adult Head    213.9 Adult Eye    370.7 Adult Brain    238.8 Adult Thoracic-Abdominal Ganglion    182.8 Adult Crop    352.3 Adult Midgut    157.1 Adult Hindgut    198.6 Adult Malpighian Tubules    326.5 Adult Fat Body    139.9 Adult Salivary Gland    188.7 Adult Heart    202.225 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    324.6 Adult Ovary    283.5 Adult Testis    321.1 Adult Male Accessory Gland    207.7 Adult Carcass    174.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033556 expression level Tissue   Expression Level Larval Central Nervous System    230.8 Larval Midgut    89.6 Larval Hindgut    136.5 Larval Malpighian Tubules    325.5 Larval Fat Body    198.7 Larval Salivary Gland    127.8 Larval Trachea    283.425 Larval Carcass    108.725 Adult Head    213.9 Adult Eye    370.7 Adult Brain    238.8 Adult Thoracic-Abdominal Ganglion    182.8 Adult Crop    352.3 Adult Midgut    157.1 Adult Hindgut    198.6 Adult Malpighian Tubules    326.5 Adult Fat Body    139.9 Adult Salivary Gland    188.7 Adult Heart    202.225 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    324.6 Adult Ovary    283.5 Adult Testis    321.1 Adult Male Accessory Gland    207.7 Adult Carcass    174.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    230.8 Larval Midgut    89.6 Larval Hindgut    136.5 Larval Malpighian Tubules    325.5 Larval Fat Body    198.7 Larval Salivary Gland    127.8 Larval Trachea    283.425 Larval Carcass    108.725 Adult Head    213.9 Adult Eye    370.7 Adult Brain    238.8 Adult Thoracic-Abdominal Ganglion    182.8 Adult Crop    352.3 Adult Midgut    157.1 Adult Hindgut    198.6 Adult Malpighian Tubules    326.5 Adult Fat Body    139.9 Adult Salivary Gland    188.7 Adult Heart    202.225 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    324.6 Adult Ovary    283.5 Adult Testis    321.1 Adult Male Accessory Gland    207.7 Adult Carcass    174.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    230.8 Larval Midgut    89.6 Larval Hindgut    136.5 Larval Malpighian Tubules    325.5 Larval Fat Body    198.7 Larval Salivary Gland    127.8 Larval Trachea    283.425 Larval Carcass    108.725 Adult Head    213.9 Adult Eye    370.7 Adult Brain    238.8 Adult Thoracic-Abdominal Ganglion    182.8 Adult Crop    352.3 Adult Midgut    157.1 Adult Hindgut    198.6 Adult Malpighian Tubules    326.5 Adult Fat Body    139.9 Adult Salivary Gland    188.7 Adult Heart    202.225 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    324.6 Adult Ovary    283.5 Adult Testis    321.1 Adult Male Accessory Gland    207.7 Adult Carcass    174.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    230.8 Larval Midgut    89.6 Larval Hindgut    136.5 Larval Malpighian Tubules    325.5 Larval Fat Body    198.7 Larval Salivary Gland    127.8 Larval Trachea    283.425 Larval Carcass    108.725 Adult Head    213.9 Adult Eye    370.7 Adult Brain    238.8 Adult Thoracic-Abdominal Ganglion    182.8 Adult Crop    352.3 Adult Midgut    157.1 Adult Hindgut    198.6 Adult Malpighian Tubules    326.5 Adult Fat Body    139.9 Adult Salivary Gland    188.7 Adult Heart    202.225 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    324.6 Adult Ovary    283.5 Adult Testis    321.1 Adult Male Accessory Gland    207.7 Adult Carcass    174.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    213.9   NA  Eye    370.7   NA  Brain    238.8   230.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    182.8   NA  Crop    352.3   89.6  Midgut    157.1   136.5  Hindgut    198.6   325.5  Malpighian Tubules    326.5   198.7  Fat Body    139.9   127.8  Salivary Gland    188.7   NA  Heart    202.225   283.425  Trachea    NA   NA  VirginFemale Spermatheca    312.8   NA  InseminatedFemale Spermatheca    324.6   NA  Ovary    283.5   NA  Testis    321.1   NA  Male Accessory Gland    207.7   108.725  Carcass    174.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033556 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12343-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 CG12343GD7576 lethal | pupal stage, with Scer\GAL4pnr-MD237 CG12343GD7576 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 CG12343GD7576 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 CG12343GD7576 visible, with Scer\GAL4pnr-MD237 CG12343GD7576 Phenotype manifest in Allele ganglion mother cell | larval stage, with Scer\GAL41407 CG12343GD7576 mesothoracic tergum, with Scer\GAL4pnr-MD237 CG12343GD7576
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG12343 Class Mutagen Stocks Known lesion CG12343EY04947 P-element activity 2 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG12343 Class Mutagen Stocks Known lesion CG12343GD7576 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG12343KK101844 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7112 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7576} NA P{KK101844} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG12343EY04947 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG12343 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033556 DroID - A comprehensive database of gene and protein interactions. • FBgn0033556 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36143
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11082 Dere\GG22714 Dgri\GH21431 Dmoj\GI20654 Dper\GL17175 Dpse\GA11568 Dsec\GM20490 Dsim\GD25952 Dvir\GJ20403 Dwil\GK15740 Dyak\GE13071
Curated drosophilid orthologs	Dpse\GA11568
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005880-PA Aedes aegypti (mosquito) AGAP010515-PA Anopheles gambiae (mosquito) XP_394026.1 Apis mellifera (honey bee) XP_001952630.1 Acyrthosiphon pisum (pea aphid) At2g16860.1 Arabidopsis thaliana (wall cress) 36608 Batrachochytrium dendrobatidis (chytrid fungus) 238139 Branchiostoma floridae (lancelet) 254518 Branchiostoma floridae (lancelet) XP_001897729.1 Brugia malayi (roundworm nematode) BGIBMGA009114-PA Bombyx mori (silk worm) ENSBTAP00000002165 Bos taurus (bovine) CN16466 Caenorhabditis brenneri (small nematode) CBP25827 Caenorhabditis briggsae (nematode) CE39587 Caenorhabditis elegans (worm) ENSCAFP00000019001 Canis familiaris (dog) ENSCINP00000006136 Ciona intestinalis (sea squirt) JA15674 Caenorhabditis japonica (nematode) cn12030 Cryptococcus neoformans (yeast-like fungus) CPIJ008327 Culex pipens (mosquito) ENSCPOP00000004790 Cavia porcellus (guinea pig) 101665 Chlamidomonas reinhardtii (green alga) RP27972 Caenorhabditis remanei (nematode) ENSCSAVP00000011324 Ciona savignyi (sedentary tunicate) 20848 Capitella spl (polychaete worm) DDB0233593 Dictyostelium discoideum (amoeba) DEHA2C03366g Debaryomyces Hansenii (yeast) 109004 Daphnia pulex (daphnia) ENSDARP00000021097 Danio rerio (zebra fish) ENSECAP00000009907 Equus caballus (horse) ENSGACP00000009699 Gymnopilus aculeatus (mushroom) ENSGALP00000001891 Gallus gallus (chicken) 184929 Hypsipyla robusta (cedar shoot borer) ENSP00000236273 Homo sapiens (human) 184158 Lottia gigantea (owl limpet) ENSMODP00000032187 Monodelphis domestica (gray opossum) ENSMMUP00000003967 Macaca mulatta (rhesus monkey) ENSMUSP00000030622 Mus musculus (house mouse) 169197 Nematostella vectensis (starlet anemone) XP_001600215.1 Nasonia vitripennis (wasp) ENSOANP00000015167 Ornithorynchus anatinus (platypus) ENSORLP00000021925 Oryzias latipes (japanese killifish) LOC_Os06g49740.1 Oryza sativa (asian rice) PHUM005381-PA Pediculus humanus (human body louse) PP10830 Pristionchus pacificus (nematode) 117104 Physcomitrella patens (moss) ENSPPYP00000001980 Pongo pygmaeus (orangutan) 72767 Phytophthora ramorum (sudden oak death pathogen) 130306 Phytophthora sojae (root rot pathogen) 831321 Populus trichocarpa (black cottonwood) ENSPTRP00000000615 Pan troglodytes (chimpanzee) ENSRNOP00000024271 Rattus norvegicus (norway rat) 4771818 Sorghum bicolor (sorghum) Smp_064500 Schistosoma mansoni (trematode parasite) SPBC3E7.13c Schizosaccharomyces pombe (fission yeast) XP_001176731.1 Strongylocentrotus purpuratus (purple sea urchin) XP_968841.1 Tribolium castaneum (red flour beetle) ENSTNIP00000020031 Tetraodon nigroviridis (green spotted pufferfish) TP03_0221 Theileria parva (parasitic protozoan) ENSTRUP00000003451 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000049327 Xenopus tropicalis (frog) YALI0B03036g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13106 NV11010 LH16930 ISCW003252 FBgn0230775 FBgn0217743 FBgn0207543 FBgn0197229 FBgn0175372 JGI_V11_109004 FBgn0071619 FBgn0154778 FBgn0143389 FBgn0128893 FBgn0114879 FBgn0088122 CPIJ008327 BGIBMGA009114 ACYPI002151 GB14256 AGAP010515 AAEL005880 PB20183 PHUM268280 GLEAN_06199
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	16628 y1 w67c23; P{EPgy2}CG12343EY04947/CyO
Kyoto	114434 yd2 w1118 P{ey-FLP.N}2; P{neoFRT}42D P{EPgy2}CG12343EY04947 /CyO y+
VDRC	v105982 P{KK101844}VIE-260B v31737 w1118; P{GD7576}v31737 v31738 w1118; P{GD7576}v31738
Genomic Clones ( 1 )
	BACR13J10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP07727
Other clones	DPiM_IP07727
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	149377 CK01.6D.A4 CK01.55C.H4 EK044862 EK254424 RP001016106 RP001019992 RP001020079 RP001021046 RP001023018 RP001023054 RP001026003 RP001026397 RP001042972 RP001046885 RP001049503
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033556 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36143
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136773 RefSeq (Proteins) • NP_610617 DDBJ / EMBL / GenBank • AAF58745 CL527776 Entrez Gene - A searchable database of RefSeq genes. • 36143 UniProtKB/TrEMBL • Q9V5Q4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • mRNA splicing factor SYF2 (IPR013260)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033556 DroID - A comprehensive database of gene and protein interactions. • FBgn0033556 DRSC - Results from RNAi screens. • FBgn0033556 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033556 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12343-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033556 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36143 InParanoid A subset of ortholog calls from InParanoid. • AAEL005880-PA Aedes aegypti (mosquito) AGAP010515-PA Anopheles gambiae (mosquito) XP_394026.1 Apis mellifera (honey bee) XP_001952630.1 Acyrthosiphon pisum (pea aphid) At2g16860.1 Arabidopsis thaliana (wall cress) 36608 Batrachochytrium dendrobatidis (chytrid fungus) 238139 Branchiostoma floridae (lancelet) 254518 Branchiostoma floridae (lancelet) XP_001897729.1 Brugia malayi (roundworm nematode) BGIBMGA009114-PA Bombyx mori (silk worm) ENSBTAP00000002165 Bos taurus (bovine) CN16466 Caenorhabditis brenneri (small nematode) CBP25827 Caenorhabditis briggsae (nematode) CE39587 Caenorhabditis elegans (worm) ENSCAFP00000019001 Canis familiaris (dog) ENSCINP00000006136 Ciona intestinalis (sea squirt) JA15674 Caenorhabditis japonica (nematode) cn12030 Cryptococcus neoformans (yeast-like fungus) CPIJ008327 Culex pipens (mosquito) ENSCPOP00000004790 Cavia porcellus (guinea pig) 101665 Chlamidomonas reinhardtii (green alga) RP27972 Caenorhabditis remanei (nematode) ENSCSAVP00000011324 Ciona savignyi (sedentary tunicate) 20848 Capitella spl (polychaete worm) DDB0233593 Dictyostelium discoideum (amoeba) DEHA2C03366g Debaryomyces Hansenii (yeast) 109004 Daphnia pulex (daphnia) ENSDARP00000021097 Danio rerio (zebra fish) ENSECAP00000009907 Equus caballus (horse) ENSGACP00000009699 Gymnopilus aculeatus (mushroom) ENSGALP00000001891 Gallus gallus (chicken) 184929 Hypsipyla robusta (cedar shoot borer) ENSP00000236273 Homo sapiens (human) 184158 Lottia gigantea (owl limpet) ENSMODP00000032187 Monodelphis domestica (gray opossum) ENSMMUP00000003967 Macaca mulatta (rhesus monkey) ENSMUSP00000030622 Mus musculus (house mouse) 169197 Nematostella vectensis (starlet anemone) XP_001600215.1 Nasonia vitripennis (wasp) ENSOANP00000015167 Ornithorynchus anatinus (platypus) ENSORLP00000021925 Oryzias latipes (japanese killifish) LOC_Os06g49740.1 Oryza sativa (asian rice) PHUM005381-PA Pediculus humanus (human body louse) PP10830 Pristionchus pacificus (nematode) 117104 Physcomitrella patens (moss) ENSPPYP00000001980 Pongo pygmaeus (orangutan) 72767 Phytophthora ramorum (sudden oak death pathogen) 130306 Phytophthora sojae (root rot pathogen) 831321 Populus trichocarpa (black cottonwood) ENSPTRP00000000615 Pan troglodytes (chimpanzee) ENSRNOP00000024271 Rattus norvegicus (norway rat) 4771818 Sorghum bicolor (sorghum) Smp_064500 Schistosoma mansoni (trematode parasite) SPBC3E7.13c Schizosaccharomyces pombe (fission yeast) XP_001176731.1 Strongylocentrotus purpuratus (purple sea urchin) XP_968841.1 Tribolium castaneum (red flour beetle) ENSTNIP00000020031 Tetraodon nigroviridis (green spotted pufferfish) TP03_0221 Theileria parva (parasitic protozoan) ENSTRUP00000003451 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000049327 Xenopus tropicalis (frog) YALI0B03036g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36143 modMine - Data generated by the modENCODE project. • FBgn0033556 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13106 NV11010 LH16930 ISCW003252 FBgn0230775 FBgn0217743 FBgn0207543 FBgn0197229 FBgn0175372 JGI_V11_109004 FBgn0071619 FBgn0154778 FBgn0143389 FBgn0128893 FBgn0114879 FBgn0088122 CPIJ008327 BGIBMGA009114 ACYPI002151 GB14256 AGAP010515 AAEL005880 PB20183 PHUM268280 GLEAN_06199
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG12343 (Keleman et al., 2009.8.5, Herold et al., 2009) Syf2 (FBrf0198798)
Name Synonym
Secondary FlyBase IDs
References ( 10 )
Research paper	Herold et al., 2009, Mol. Cell. Biol. 29(1): 281--301 Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. [FBrf0207172]
Supplementary material	Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Protein sequence record	Pre-mRNA-splicing factor Syf2. [FBrf0198798]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177]