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Gene Dmel\fbl6

General Information
Symbol	Dmel\fbl6	Species	D. melanogaster
Name		Annotation symbol	CG13213
Feature type	protein_coding_gene	FlyBase ID	FBgn0033609
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	47E6-47F1	Sequence location	2R:7,172,653..7,177,253 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\fbl6 (CG13213, FBgn0033609). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 8 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: F-box domain, Skp2-like; Leucine-rich repeat. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1641381_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of fbl6. Gene sequence location is 2R:7172653..7177253.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN50609 BKN50843 HFA06335 BKN28474
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 47E6-47F1   Limits computationally determined from genome sequence between P{PZ}rM547 and P{lacW}Fppsk06103&P{lacW}Fppsk03514
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\fbl6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) fbl6-RA FBtr0088180  NM_136821   3676   720 fbl6-RB FBtr0088179  NM_165815   3351   720 fbl6-RC FBtr0088178  NM_165816   3072   720
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein fbl6-PA   FBpp0087276   77.7   720   7.44     NP_610665   AAF58680 fbl6-PB   FBpp0087275   77.7   720   7.44     NP_725019   AAF58681 fbl6-PC   FBpp0087274   77.7   720   7.44     NP_725020   AAM68724
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat (IPR001611) F-box domain, Skp2-like (IPR022364)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58680   AE013599 AAF58681   AE013599 AAM68724   AI402139   AI512481   AI534900   AI544242   AW944165   AY050225 AAK84924   BI367917   BI368991   BI371385   BI372246   BI374036   BI374529   BP552480   BT023808   CK131158   CL528074   CO190933   CO275996   CO289782   CO298738   CO304623   CO305160   CO306916   CO310871   CO314299   CO314439   CO324021   CO331753   CO331768   CO332983   CO343893   CO345369   CZ478625   EC061237   EC065709   EC065801   EC067888   EC076341   EC077322   EC080439   EC081720   EC087591   EC087880   EC197528   EC211770   EC228139   EC228739   EC235051   EC239687   EC241431   EC249107   EC250894   EC255027   EC259764   GH743042   GH762962   GH764888   GH768872   GH769544   GH941939   GH942643   GH943713   GH944727   GH947463   GH947682   GH949596   GH951380   GH960599   GH961376   GH962303   GH963085   GH964593   GH964655   GH964810   GH966943   GH968447   GH974971   GH975177   GH975458   GH977640   GH980136   GH981080   GH982214   GH982799
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q961T2 Q494G8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   mushroom body | restricted   (Kobayashi et al., 2006)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033609    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033609 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033609 expression level Developmental Stage   Expression Level embryo 00-02hr    1818 embryo 02-04hr    946 embryo 04-06hr    2169 embryo 06-08hr    2373 embryo 08-10hr    1846 embryo 10-12hr    1534 embryo 12-14hr    1322 embryo 14-16hr    801 embryo 16-18hr    598 embryo 18-20hr    535 embryo 20-22hr    485 embryo 22-24hr    543 larva L1    405 larva L2    414 larva L3 12hr old    305 larva L3 puffstage 1-2    442 larva L3 puffstage 3-6    744 larva L3 puffstage 7-9    891 white prepupae new    878 white prepupae 12hr    1149 white prepupae 24hr    1297 pupae 2d postWPP    1098 pupae 3d postWPP    581 pupae 4d postWPP    335 adult male 01day    569 adult male 05day    657 adult male 30day    608 adult female 01day    696 adult female 05day    1097 adult female 30day    1064 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1818) embryo 02-04hr  (946) embryo 04-06hr  (2169) embryo 06-08hr  (2373) embryo 08-10hr  (1846) embryo 10-12hr  (1534) embryo 12-14hr  (1322) embryo 14-16hr  (801) embryo 16-18hr  (598) embryo 18-20hr  (535) embryo 20-22hr  (485) embryo 22-24hr  (543) larva L1  (405) larva L2  (414) larva L3 12hr old  (305) larva L3 puffstage 1-2  (442) larva L3 puffstage 3-6  (744) larva L3 puffstage 7-9  (891) white prepupae new  (878) white prepupae 12hr  (1149) white prepupae 24hr  (1297) pupae 2d postWPP  (1098) pupae 3d postWPP  (581) pupae 4d postWPP  (335) adult male 01day  (569) adult male 05day  (657) adult male 30day  (608) adult female 01day  (696) adult female 05day  (1097) adult female 30day  (1064) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1818) embryo 02-04hr    946 embryo 04-06hr  (2169) embryo 06-08hr  (2373) embryo 08-10hr  (1846) embryo 10-12hr  (1534) embryo 12-14hr    1322 embryo 14-16hr    801 embryo 16-18hr    598 embryo 18-20hr    535 embryo 20-22hr    485 embryo 22-24hr    543 larva L1    405 larva L2    414 larva L3 12hr old    305 larva L3 puffstage 1-2    442 larva L3 puffstage 3-6    744 larva L3 puffstage 7-9    891 white prepupae new    878 white prepupae 12hr    1149 white prepupae 24hr    1297 pupae 2d postWPP    1098 pupae 3d postWPP    581 pupae 4d postWPP    335 adult male 01day    569 adult male 05day    657 adult male 30day    608 adult female 01day    696 adult female 05day    1097 adult female 30day    1064 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1818 embryo 02-04hr    946 embryo 04-06hr    2169 embryo 06-08hr    2373 embryo 08-10hr    1846 embryo 10-12hr    1534 embryo 12-14hr    1322 embryo 14-16hr    801 embryo 16-18hr    598 embryo 18-20hr    535 embryo 20-22hr    485 embryo 22-24hr    543 larva L1    405 larva L2    414 larva L3 12hr old    305 larva L3 puffstage 1-2    442 larva L3 puffstage 3-6    744 larva L3 puffstage 7-9    891 white prepupae new    878 white prepupae 12hr    1149 white prepupae 24hr    1297 pupae 2d postWPP    1098 pupae 3d postWPP    581 pupae 4d postWPP    335 adult male 01day    569 adult male 05day    657 adult male 30day    608 adult female 01day    696 adult female 05day    1097 adult female 30day    1064 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1818 embryo 02-04hr    946 embryo 04-06hr    2169 embryo 06-08hr    2373 embryo 08-10hr    1846 embryo 10-12hr    1534 embryo 12-14hr    1322 embryo 14-16hr    801 embryo 16-18hr    598 embryo 18-20hr    535 embryo 20-22hr    485 embryo 22-24hr    543 larva L1    405 larva L2    414 larva L3 12hr old    305 larva L3 puffstage 1-2    442 larva L3 puffstage 3-6    744 larva L3 puffstage 7-9    891 white prepupae new    878 white prepupae 12hr    1149 white prepupae 24hr    1297 pupae 2d postWPP    1098 pupae 3d postWPP    581 pupae 4d postWPP    335 adult male 01day    569 adult male 05day    657 adult male 30day    608 adult female 01day    696 adult female 05day    1097 adult female 30day    1064 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033609 expression level Developmental Stage   Expression Level embryo 00-02hr    1818 embryo 02-04hr    946 embryo 04-06hr    2169 embryo 06-08hr    2373 embryo 08-10hr    1846 embryo 10-12hr    1534 embryo 12-14hr    1322 embryo 14-16hr    801 embryo 16-18hr    598 embryo 18-20hr    535 embryo 20-22hr    485 embryo 22-24hr    543 larva L1    405 larva L2    414 larva L3 12hr old    305 larva L3 puffstage 1-2    442 larva L3 puffstage 3-6    744 larva L3 puffstage 7-9    891 white prepupae new    878 white prepupae 12hr    1149 white prepupae 24hr    1297 pupae 2d postWPP    1098 pupae 3d postWPP    581 pupae 4d postWPP    335 adult male 01day    569 adult male 05day    657 adult male 30day    608 adult female 01day    696 adult female 05day    1097 adult female 30day    1064 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1818) embryo 02-04hr  (946) embryo 04-06hr  (2169) embryo 06-08hr  (2373) embryo 08-10hr  (1846) embryo 10-12hr  (1534) embryo 12-14hr  (1322) embryo 14-16hr  (801) embryo 16-18hr  (598) embryo 18-20hr  (535) embryo 20-22hr  (485) embryo 22-24hr  (543) larva L1  (405) larva L2  (414) larva L3 12hr old  (305) larva L3 puffstage 1-2  (442) larva L3 puffstage 3-6  (744) larva L3 puffstage 7-9  (891) white prepupae new  (878) white prepupae 12hr  (1149) white prepupae 24hr  (1297) pupae 2d postWPP  (1098) pupae 3d postWPP  (581) pupae 4d postWPP  (335) adult male 01day  (569) adult male 05day  (657) adult male 30day  (608) adult female 01day  (696) adult female 05day  (1097) adult female 30day  (1064) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1818 embryo 02-04hr    946 embryo 04-06hr  2169 embryo 06-08hr  2373 embryo 08-10hr  1846 embryo 10-12hr  1534 embryo 12-14hr    1322 embryo 14-16hr    801 embryo 16-18hr    598 embryo 18-20hr    535 embryo 20-22hr    485 embryo 22-24hr    543 larva L1    405 larva L2    414 larva L3 12hr old    305 larva L3 puffstage 1-2    442 larva L3 puffstage 3-6    744 larva L3 puffstage 7-9    891 white prepupae new    878 white prepupae 12hr    1149 white prepupae 24hr    1297 pupae 2d postWPP    1098 pupae 3d postWPP    581 pupae 4d postWPP    335 adult male 01day    569 adult male 05day    657 adult male 30day    608 adult female 01day    696 adult female 05day    1097 adult female 30day    1064 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1818 embryo 02-04hr    946 embryo 04-06hr    2169 embryo 06-08hr    2373 embryo 08-10hr    1846 embryo 10-12hr    1534 embryo 12-14hr    1322 embryo 14-16hr    801 embryo 16-18hr    598 embryo 18-20hr    535 embryo 20-22hr    485 embryo 22-24hr    543 larva L1    405 larva L2    414 larva L3 12hr old    305 larva L3 puffstage 1-2    442 larva L3 puffstage 3-6    744 larva L3 puffstage 7-9    891 white prepupae new    878 white prepupae 12hr    1149 white prepupae 24hr    1297 pupae 2d postWPP    1098 pupae 3d postWPP    581 pupae 4d postWPP    335 adult male 01day    569 adult male 05day    657 adult male 30day    608 adult female 01day    696 adult female 05day    1097 adult female 30day    1064 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1818 embryo 02-04hr    946 embryo 04-06hr    2169 embryo 06-08hr    2373 embryo 08-10hr    1846 embryo 10-12hr    1534 embryo 12-14hr    1322 embryo 14-16hr    801 embryo 16-18hr    598 embryo 18-20hr    535 embryo 20-22hr    485 embryo 22-24hr    543 larva L1    405 larva L2    414 larva L3 12hr old    305 larva L3 puffstage 1-2    442 larva L3 puffstage 3-6    744 larva L3 puffstage 7-9    891 white prepupae new    878 white prepupae 12hr    1149 white prepupae 24hr    1297 pupae 2d postWPP    1098 pupae 3d postWPP    581 pupae 4d postWPP    335 adult male 01day    569 adult male 05day    657 adult male 30day    608 adult female 01day    696 adult female 05day    1097 adult female 30day    1064 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033609    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033609 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033609 expression level Tissue   Expression Level Larval Central Nervous System    311.325 Larval Midgut    69.9 Larval Hindgut    104.8 Larval Malpighian Tubules    126.5 Larval Fat Body    121.7 Larval Salivary Gland    184 Larval Trachea    218.4 Larval Carcass    117.275 Adult Head    148.9 Adult Eye    178.475 Adult Brain    279.3 Adult Thoracic-Abdominal Ganglion    201.3 Adult Crop    139 Adult Midgut    80 Adult Hindgut    103.9 Adult Malpighian Tubules    191.3 Adult Fat Body    82.5 Adult Salivary Gland    145.9 Adult Heart    82.45 Adult VirginFemale Spermatheca    191.5 Adult InseminatedFemale Spermatheca    183.6 Adult Ovary    269.7 Adult Testis    25.9 Adult Male Accessory Gland    165.6 Adult Carcass    95.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    311.325 Larval Midgut    69.9 Larval Hindgut    104.8 Larval Malpighian Tubules    126.5 Larval Fat Body    121.7 Larval Salivary Gland    184 Larval Trachea    218.4 Larval Carcass    117.275 Adult Head    148.9 Adult Eye    178.475 Adult Brain    279.3 Adult Thoracic-Abdominal Ganglion    201.3 Adult Crop    139 Adult Midgut    80 Adult Hindgut    103.9 Adult Malpighian Tubules    191.3 Adult Fat Body    82.5 Adult Salivary Gland    145.9 Adult Heart    82.45 Adult VirginFemale Spermatheca    191.5 Adult InseminatedFemale Spermatheca    183.6 Adult Ovary    269.7 Adult Testis    25.9 Adult Male Accessory Gland    165.6 Adult Carcass    95.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    311.325 Larval Midgut    69.9 Larval Hindgut    104.8 Larval Malpighian Tubules    126.5 Larval Fat Body    121.7 Larval Salivary Gland    184 Larval Trachea    218.4 Larval Carcass    117.275 Adult Head    148.9 Adult Eye    178.475 Adult Brain    279.3 Adult Thoracic-Abdominal Ganglion    201.3 Adult Crop    139 Adult Midgut    80 Adult Hindgut    103.9 Adult Malpighian Tubules    191.3 Adult Fat Body    82.5 Adult Salivary Gland    145.9 Adult Heart    82.45 Adult VirginFemale Spermatheca    191.5 Adult InseminatedFemale Spermatheca    183.6 Adult Ovary    269.7 Adult Testis    25.9 Adult Male Accessory Gland    165.6 Adult Carcass    95.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    311.325 Larval Midgut    69.9 Larval Hindgut    104.8 Larval Malpighian Tubules    126.5 Larval Fat Body    121.7 Larval Salivary Gland    184 Larval Trachea    218.4 Larval Carcass    117.275 Adult Head    148.9 Adult Eye    178.475 Adult Brain    279.3 Adult Thoracic-Abdominal Ganglion    201.3 Adult Crop    139 Adult Midgut    80 Adult Hindgut    103.9 Adult Malpighian Tubules    191.3 Adult Fat Body    82.5 Adult Salivary Gland    145.9 Adult Heart    82.45 Adult VirginFemale Spermatheca    191.5 Adult InseminatedFemale Spermatheca    183.6 Adult Ovary    269.7 Adult Testis    25.9 Adult Male Accessory Gland    165.6 Adult Carcass    95.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033609 expression level Tissue   Expression Level Larval Central Nervous System    311.325 Larval Midgut    69.9 Larval Hindgut    104.8 Larval Malpighian Tubules    126.5 Larval Fat Body    121.7 Larval Salivary Gland    184 Larval Trachea    218.4 Larval Carcass    117.275 Adult Head    148.9 Adult Eye    178.475 Adult Brain    279.3 Adult Thoracic-Abdominal Ganglion    201.3 Adult Crop    139 Adult Midgut    80 Adult Hindgut    103.9 Adult Malpighian Tubules    191.3 Adult Fat Body    82.5 Adult Salivary Gland    145.9 Adult Heart    82.45 Adult VirginFemale Spermatheca    191.5 Adult InseminatedFemale Spermatheca    183.6 Adult Ovary    269.7 Adult Testis    25.9 Adult Male Accessory Gland    165.6 Adult Carcass    95.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    311.325 Larval Midgut    69.9 Larval Hindgut    104.8 Larval Malpighian Tubules    126.5 Larval Fat Body    121.7 Larval Salivary Gland    184 Larval Trachea    218.4 Larval Carcass    117.275 Adult Head    148.9 Adult Eye    178.475 Adult Brain    279.3 Adult Thoracic-Abdominal Ganglion    201.3 Adult Crop    139 Adult Midgut    80 Adult Hindgut    103.9 Adult Malpighian Tubules    191.3 Adult Fat Body    82.5 Adult Salivary Gland    145.9 Adult Heart    82.45 Adult VirginFemale Spermatheca    191.5 Adult InseminatedFemale Spermatheca    183.6 Adult Ovary    269.7 Adult Testis    25.9 Adult Male Accessory Gland    165.6 Adult Carcass    95.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    311.325 Larval Midgut    69.9 Larval Hindgut    104.8 Larval Malpighian Tubules    126.5 Larval Fat Body    121.7 Larval Salivary Gland    184 Larval Trachea    218.4 Larval Carcass    117.275 Adult Head    148.9 Adult Eye    178.475 Adult Brain    279.3 Adult Thoracic-Abdominal Ganglion    201.3 Adult Crop    139 Adult Midgut    80 Adult Hindgut    103.9 Adult Malpighian Tubules    191.3 Adult Fat Body    82.5 Adult Salivary Gland    145.9 Adult Heart    82.45 Adult VirginFemale Spermatheca    191.5 Adult InseminatedFemale Spermatheca    183.6 Adult Ovary    269.7 Adult Testis    25.9 Adult Male Accessory Gland    165.6 Adult Carcass    95.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    311.325 Larval Midgut    69.9 Larval Hindgut    104.8 Larval Malpighian Tubules    126.5 Larval Fat Body    121.7 Larval Salivary Gland    184 Larval Trachea    218.4 Larval Carcass    117.275 Adult Head    148.9 Adult Eye    178.475 Adult Brain    279.3 Adult Thoracic-Abdominal Ganglion    201.3 Adult Crop    139 Adult Midgut    80 Adult Hindgut    103.9 Adult Malpighian Tubules    191.3 Adult Fat Body    82.5 Adult Salivary Gland    145.9 Adult Heart    82.45 Adult VirginFemale Spermatheca    191.5 Adult InseminatedFemale Spermatheca    183.6 Adult Ovary    269.7 Adult Testis    25.9 Adult Male Accessory Gland    165.6 Adult Carcass    95.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    148.9   NA  Eye    178.475   NA  Brain    279.3   311.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    201.3   NA  Crop    139   69.9  Midgut    80   104.8  Hindgut    103.9   126.5  Malpighian Tubules    191.3   121.7  Fat Body    82.5   184  Salivary Gland    145.9   NA  Heart    82.45   218.4  Trachea    NA   NA  VirginFemale Spermatheca    191.5   NA  InseminatedFemale Spermatheca    183.6   NA  Ovary    269.7   NA  Testis    25.9   NA  Male Accessory Gland    165.6   117.275  Carcass    95.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033609 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13213-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 fbl6GD7963 viable fbl6EY07953 Sterility Allele fertile fbl6EY07953 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 fbl6GD7963 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 fbl6GD7963 trichogen cell, with Scer\GAL4pnr-MD237 fbl6GD7963
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of fbl6 Class Mutagen Stocks Known lesion fbl6NP0326 2 Yes fbl6EY18388 P-element activity 1 -- fbl6d01591 0 -- fbl6e00781 piggyBac transposase 0 -- fbl6EY07953 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of fbl6 Class Mutagen Stocks Known lesion fbl6GD7963 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes fbl6JF01318 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fbl6KK108474 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6060 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK108474} NA P{TRiP.JF01318} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}fbl6EY07953 NA P{EPgy2}fbl6EY18388 NA P{XP}fbl6d01591 NA insertion of enhancer trap binary system P{GawB}fbl6NP0326 No miscellaneous insertions PBac{RB}fbl6e00781 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions fbl6 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61996 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033609 DroID - A comprehensive database of gene and protein interactions. • FBgn0033609 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36201
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12419 Dere\GG22677 Dgri\GH21935 Dmoj\GI19643 Dper\GL16743 Dpse\GA12126 Dsec\GM20455 Dsim\GD25923 Dvir\GJ15008 Dwil\GK21622 Dyak\GE13033
Curated drosophilid orthologs	Dpse\GA12126
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013568-PA Aedes aegypti (mosquito) AGAP006431-PA Anopheles gambiae (mosquito) XP_001945048.1 Acyrthosiphon pisum (pea aphid) 76210 Branchiostoma floridae (lancelet) ENSBTAP00000001141 Bos taurus (bovine) ENSCAFP00000002299 Canis familiaris (dog) CPIJ004608 Culex pipens (mosquito) ENSCPOP00000011963 Cavia porcellus (guinea pig) 200821 Capitella spl (polychaete worm) DDB0218617 Dictyostelium discoideum (amoeba) 23392 Daphnia pulex (daphnia) ENSECAP00000008196 Equus caballus (horse) ENSGACP00000003353 Gymnopilus aculeatus (mushroom) ENSP00000330098 Homo sapiens (human) KLLA0B04774g Kluyveromyces lactis (yeast) 132773 Lottia gigantea (owl limpet) ENSMODP00000013407 Monodelphis domestica (gray opossum) ENSMMUP00000009667 Macaca mulatta (rhesus monkey) ENSMUSP00000023219 Mus musculus (house mouse) 239446 Nematostella vectensis (starlet anemone) ENSOANP00000007200 Ornithorynchus anatinus (platypus) 34651 Ostreococcus tauri (green alga) PHUM003047-PA Pediculus humanus (human body louse) ENSPTRP00000035404 Pan troglodytes (chimpanzee) ENSRNOP00000035719 Rattus norvegicus (norway rat) XP_783241.2 Strongylocentrotus purpuratus (purple sea urchin) XP_972734.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230739 FBgn0223614 FBgn0202208 FBgn0197201 FBgn0175337 JGI_V11_23392 FBgn0072174 FBgn0154347 FBgn0142380 FBgn0129396 FBgn0114842 FBgn0089456 CPIJ004608 BGIBMGA007718 ACYPI010023 AGAP006431 AAEL013568 PHUM105680 GLEAN_04399
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	31482 y1 v1; P{TRiP.JF01318}attP2 23098 y1 w67c23; P{EPgy2}fbl6EY18388
Kyoto	103587 y* w*; P{GawB}fbl6NP0326 / CyO, P{UAS-lacZ.UW14}UW14 112137 y* w*; P{GawB}fbl6NP0326 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v100758 P{KK108474}VIE-260B v43004 w1118; P{GD7963}v43004 v43002 w1118; P{GD7963}v43002/TM3
Genomic Clones ( 2 )
	BACR09B12 BACR29G22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 80 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE55062 SD01170
Other clones	DPiM_RE55062
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH08521 GH08590 LD44368 RE53790 RE58263 RE59161 RE61546 RE62147 SD10727
Other clones	19337 60758 63163 100113 103288 104258 122152 125300 125345 145136 194126 214245.26 214471.20 274254 274344 280593 CK01.32A.D7 CK01.62B.D8 CK01.92B.A10 CK01.117D.H6 CK01.145A.D12 EK050134 EK072035 EK119346 EK173721 EK192263 EK222848 EK235653 EK236408 EK245318 EK247553 EK252762 EK301623 EK301644 EK305336 EP18314 EP21919 FGM219A04 RP001011177 RP001019023 RP001037812 RP001052964 RP001055914 RP004165732 RP004183719 RP004205831 RP004208944 RP004217105 RP004223567 RP004234025 RP004238313 RP004243068 RP004247762 RP004260851 RP004267757 RP004284783 RP004342500 RP004349218 RP004352935 RP004454698 RP004474470 RP004499050 RP004500362 RP004501876 RP004518098 RP004526679 RP004536005 RP004542925
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033609 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36201
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: fbl6 CG13213 (Roukens et al., 2008)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136821 NM_165815 NM_165816 RefSeq (Proteins) • NP_610665 NP_725019 NP_725020 DDBJ / EMBL / GenBank • AAF58680 AAF58681 AAK84924 AAM68724 AI534900 AW944165 AY050225 BI368991 CL528074 CZ478625 Entrez Gene - A searchable database of RefSeq genes. • 36201 UniProtKB/TrEMBL • Q494G8 Q961T2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat (IPR001611) F-box domain, Skp2-like (IPR022364)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61996 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033609 DroID - A comprehensive database of gene and protein interactions. • FBgn0033609 DRSC - Results from RNAi screens. • FBgn0033609 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033609 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13213-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033609 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36201 InParanoid A subset of ortholog calls from InParanoid. • AAEL013568-PA Aedes aegypti (mosquito) AGAP006431-PA Anopheles gambiae (mosquito) XP_001945048.1 Acyrthosiphon pisum (pea aphid) 76210 Branchiostoma floridae (lancelet) ENSBTAP00000001141 Bos taurus (bovine) ENSCAFP00000002299 Canis familiaris (dog) CPIJ004608 Culex pipens (mosquito) ENSCPOP00000011963 Cavia porcellus (guinea pig) 200821 Capitella spl (polychaete worm) DDB0218617 Dictyostelium discoideum (amoeba) 23392 Daphnia pulex (daphnia) ENSECAP00000008196 Equus caballus (horse) ENSGACP00000003353 Gymnopilus aculeatus (mushroom) ENSP00000330098 Homo sapiens (human) KLLA0B04774g Kluyveromyces lactis (yeast) 132773 Lottia gigantea (owl limpet) ENSMODP00000013407 Monodelphis domestica (gray opossum) ENSMMUP00000009667 Macaca mulatta (rhesus monkey) ENSMUSP00000023219 Mus musculus (house mouse) 239446 Nematostella vectensis (starlet anemone) ENSOANP00000007200 Ornithorynchus anatinus (platypus) 34651 Ostreococcus tauri (green alga) PHUM003047-PA Pediculus humanus (human body louse) ENSPTRP00000035404 Pan troglodytes (chimpanzee) ENSRNOP00000035719 Rattus norvegicus (norway rat) XP_783241.2 Strongylocentrotus purpuratus (purple sea urchin) XP_972734.1 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36201 modMine - Data generated by the modENCODE project. • FBgn0033609 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230739 FBgn0223614 FBgn0202208 FBgn0197201 FBgn0175337 JGI_V11_23392 FBgn0072174 FBgn0154347 FBgn0142380 FBgn0129396 FBgn0114842 FBgn0089456 CPIJ004608 BGIBMGA007718 ACYPI010023 AGAP006431 AAEL013568 PHUM105680 GLEAN_04399
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG13213 (Roukens et al., 2008, Kobayashi et al., 2006, Keleman et al., 2009.8.5, Ni et al., 2008) fbl6 (Roukens et al., 2008)
Name Synonym	CG13213
Secondary FlyBase IDs
References ( 20 )
Research paper	Ni et al., 2008, Nature Methods 5(1): 49--51 Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. [FBrf0200406] Roukens et al., 2008, Mol. Cell. Biol. 28(13): 4394--4406 Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination. [FBrf0205459] Kobayashi et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103(39): 14417--14422 Differential microarray analysis of Drosophila mushroom body transcripts using chemical ablation. [FBrf0194633] Boutros et al., 2002, Dev. Cell 3(5): 711--722 Sequential activation of signaling pathways during innate immune responses in Drosophila. [FBrf0151904] Brody et al., 2002, Mech. Dev. 113(1): 41--59 Identification of novel Drosophila neural precursor genes using a differential embryonic head cDNA screen. [FBrf0147137] Das et al., 2002, Dev. Genes Evol. 212(3): 134--140 A conserved F-box gene with unusual transcript localization. [FBrf0148953]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Review	Ou et al., 2003, Trends Genet. 19(7): 382--389 Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. [FBrf0160832]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Bellen, 2007.2.7, batch722.xml batch722.xml [FBrf0191800] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]