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Gene Dmel\Ir48b

General Information
Symbol	Dmel\Ir48b	Species	D. melanogaster
Name	Ionotropic receptor 48b	Annotation symbol	CG13195
Feature type	protein_coding_gene	FlyBase ID	FBgn0033648
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	IR48b
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	48C2-48C2	Sequence location	2R:7,588,152..7,589,954 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ionotropic receptor 48b is referred to in FlyBase by the symbol Dmel\Ir48b (CG13195, FBgn0033648). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ligand-gated ion channel activity. Based on sequence similarity, it is predicted to be involved in the biological process: detection of chemical stimulus. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely low expression to a trough of no expression detected. , at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1628545_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ir48b. Gene sequence location is 2R:7588152..7589954.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 48C2-48C2   Limits computationally determined from genome sequence between P{EP}walEP825&P{PZ}wal02516 and P{PZ}Ef1α48D01275
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ir48b for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ir48b-RA FBtr0088080  NM_136853   1803   600
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ir48b-PA   FBpp0087185   69.6   600   6.68     NP_610697   AAF58625
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58625
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z8N9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    1 Larval Hindgut    4.8 Larval Malpighian Tubules    3.7 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    0.55 Larval Carcass    3.85 Adult Head    1.2 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    1.2 Adult Midgut    1.6 Adult Hindgut    1.9 Adult Malpighian Tubules    2.4 Adult Fat Body    2.7 Adult Salivary Gland    2.7 Adult Heart    1.625 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    1 Adult Testis    1.1 Adult Male Accessory Gland    17.4 Adult Carcass    6.1 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    1 Larval Hindgut    4.8 Larval Malpighian Tubules    3.7 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    0.55 Larval Carcass    3.85 Adult Head    1.2 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    1.2 Adult Midgut    1.6 Adult Hindgut    1.9 Adult Malpighian Tubules    2.4 Adult Fat Body    2.7 Adult Salivary Gland    2.7 Adult Heart    1.625 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    1 Adult Testis    1.1 Adult Male Accessory Gland    17.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    1 Larval Hindgut    4.8 Larval Malpighian Tubules    3.7 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    0.55 Larval Carcass    3.85 Adult Head    1.2 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    1.2 Adult Midgut    1.6 Adult Hindgut    1.9 Adult Malpighian Tubules    2.4 Adult Fat Body    2.7 Adult Salivary Gland    2.7 Adult Heart    1.625 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    1 Adult Testis    1.1 Adult Male Accessory Gland    17.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    1 Larval Hindgut    4.8 Larval Malpighian Tubules    3.7 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    0.55 Larval Carcass    3.85 Adult Head    1.2 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    1.2 Adult Midgut    1.6 Adult Hindgut    1.9 Adult Malpighian Tubules    2.4 Adult Fat Body    2.7 Adult Salivary Gland    2.7 Adult Heart    1.625 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    1 Adult Testis    1.1 Adult Male Accessory Gland    17.4 Adult Carcass    6.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    1 Larval Hindgut    4.8 Larval Malpighian Tubules    3.7 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    0.55 Larval Carcass    3.85 Adult Head    1.2 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    1.2 Adult Midgut    1.6 Adult Hindgut    1.9 Adult Malpighian Tubules    2.4 Adult Fat Body    2.7 Adult Salivary Gland    2.7 Adult Heart    1.625 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    1 Adult Testis    1.1 Adult Male Accessory Gland    17.4 Adult Carcass    6.1 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    1 Larval Hindgut    4.8 Larval Malpighian Tubules    3.7 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    0.55 Larval Carcass    3.85 Adult Head    1.2 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    1.2 Adult Midgut    1.6 Adult Hindgut    1.9 Adult Malpighian Tubules    2.4 Adult Fat Body    2.7 Adult Salivary Gland    2.7 Adult Heart    1.625 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    1 Adult Testis    1.1 Adult Male Accessory Gland    17.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    1 Larval Hindgut    4.8 Larval Malpighian Tubules    3.7 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    0.55 Larval Carcass    3.85 Adult Head    1.2 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    1.2 Adult Midgut    1.6 Adult Hindgut    1.9 Adult Malpighian Tubules    2.4 Adult Fat Body    2.7 Adult Salivary Gland    2.7 Adult Heart    1.625 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    1 Adult Testis    1.1 Adult Male Accessory Gland    17.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    1 Larval Hindgut    4.8 Larval Malpighian Tubules    3.7 Larval Fat Body    1.3 Larval Salivary Gland    2 Larval Trachea    0.55 Larval Carcass    3.85 Adult Head    1.2 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    4.2 Adult Crop    1.2 Adult Midgut    1.6 Adult Hindgut    1.9 Adult Malpighian Tubules    2.4 Adult Fat Body    2.7 Adult Salivary Gland    2.7 Adult Heart    1.625 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    1 Adult Testis    1.1 Adult Male Accessory Gland    17.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1.2   NA  Eye    1.1   NA  Brain    0.9   2.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.2   NA  Crop    1.2   1  Midgut    1.6   4.8  Hindgut    1.9   3.7  Malpighian Tubules    2.4   1.3  Fat Body    2.7   2  Salivary Gland    2.7   NA  Heart    1.625   0.55  Trachea    NA   NA  VirginFemale Spermatheca    0.5   NA  InseminatedFemale Spermatheca    0.7   NA  Ovary    1   NA  Testis    1.1   NA  Male Accessory Gland    no informative data   3.85  Carcass    6.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033648 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13195-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Ir48bGD1938 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Ir48b Class Mutagen Stocks Known lesion Ir48bMB02315 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ir48b Class Mutagen Stocks Known lesion Ir48bGD1938 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ir48bKK106336 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK106336} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Ir48bMB02315 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
ligand-gated ion channel activity inferred from sequence model (Benton et al., 2009)
Biological Process
CV term Evidence References
detection of chemical stimulus inferred from sequence or structural similarity with Ir92a (Benton et al., 2009)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence model (Benton et al., 2009)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ir48b allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0033648
Orthologs
OrthoDB Orthologs (21) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6KD75X Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG690654 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6KD75X)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ir48b     Drosophila simulans   Dsim\GD25887 Y   Drosophila simulans   Dsim\GD25888     Drosophila sechellia   Dsec\GM20411 Y   Drosophila erecta   Dere\GG22633 Y   Drosophila yakuba   Dyak\GE13502 Y   Drosophila yakuba   Dyak\GE13503     Drosophila ananassae   Dana\GF13407 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12110 Y   Drosophila persimilis   Dper\GL10252 Y   Drosophila willistoni   Dwil\GK17922 Y   Drosophila virilis   Dvir\GJ21458 Y   Drosophila mojavensis   Dmoj\GI18381 Y   Drosophila grimshawi   Dgri\GH22898 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG690654)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015473 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15623 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15625 Y Tribolium castaneum Red flour beetle  Tcas\TC005361 Y Tribolium castaneum Red flour beetle  Tcas\TC000845 Y Tribolium castaneum Red flour beetle  Tcas\TC011308 Y Tribolium castaneum Red flour beetle  Tcas\TC015624 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25887 Drosophila sechellia Dsec\GM20411 Drosophila erecta Dere\GG22633 Drosophila yakuba Dyak\GE13502 Drosophila ananassae Dana\GF13407 Drosophila pseudoobscura pseudoobscura Dpse\GA12110 Drosophila persimilis Dper\GL10252 Drosophila willistoni Dwil\GK17922 Drosophila virilis Dvir\GJ21458 Drosophila mojavensis Dmoj\GI18381 Drosophila grimshawi Dgri\GH22898
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	23473 w1118; Mi{ET1}Ir48bMB02315
VDRC	v107565 P{KK106336}VIE-260B v45912 w1118; P{GD1938}v45912 v45913 w1118; P{GD1938}v45913/TM3
Genomic Clones ( 2 )
	BACR35F01 BACR38D12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033648 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36254
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ir48b CG13195 (Benton et al., 2009)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136853 RefSeq (Proteins) • NP_610697 DDBJ / EMBL / GenBank • AAF58625 Entrez Gene - A searchable database of RefSeq genes. • 36254 UniProtKB/TrEMBL • A1Z8N9
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0033648 DRSC - Results from RNAi screens. • FBgn0033648 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033648 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13195-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033648 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36254 modMine - Data generated by the modENCODE project. • FBgn0033648
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG13195 (Croset et al., 2010, Benton et al., 2009, Keleman et al., 2009.8.5, Kadam et al., 2009) DmelIR48b (Croset et al., 2010) Ir48b   IR48b (Benton et al., 2009, Croset et al., 2010)
Name Synonym	CG13195   ionotropic receptor 48b (Benton et al., 2009) Ionotropic receptor 48b
Secondary FlyBase IDs
References ( 10 )
Research paper	Croset et al., 2010, PLoS Genet. 6(8): e1001064 Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. [FBrf0211681] Benton et al., 2009, Cell 136(1): 149--162 Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. [FBrf0206496] Kadam et al., 2009, Development 136(5): 739--747 FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation. [FBrf0206790] Stathopoulos et al., 2004, Genes Dev. 18(6): 687--699 pyramus and thisbe: fGF genes that pattern the mesoderm of Drosophila embryos. [FBrf0174649]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Croset et al., 2010, PLoS Genet. 6(8): Supporting Information: Table S3. [FBrf0219605] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Bellen, 2007.4.5, batch731.xml batch731.xml [FBrf0191801] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]