Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir48c using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Ir48c in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The Ir48c gene, one of 44 "divergent" ionotropic receptor genes in D. melanogaster, may have been derived from an ancestral ionotropic receptor gene by retroposition, and in some cases, subsequent gene duplication.
FlyBase curator comment: 'Tango3' has been renamed to 'Ir48c' for the following reasons: i) This gene was originally named 'Tango3' based on a genome-wide RNAi screen (FBrf0191232, 2006), but a subsequent screen (FBrf0209739, 2010), which claimed to be more robust, failed to validate a role in secretion. Thus calling this gene 'Tango3' is likely inaccurate/misleading. ii) Two other papers refer to this gene as 'IR48c' (FBrf0206496, 2009; FBrf0211681, 2010), as it's a member of the Ionotropic Receptor family.
dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion.