FGFs involved in mesodermal development - ligands for Heartless - Thisbe, released from olfactory neurons, particularly from local interneurons, instructs ensheathing glia to wrap each glomerulus
Gene model reviewed during 5.49
Gene model reviewed during 5.56
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ths using the Feature Mapper tool.
ths is expressed in the cells that serve as substrate for mesoderm cells during migration.
Transcript is expressed in broad lateral stripes in the presumptive neurogenic ectoderm.
GBrowse - Visual display of RNA-Seq signalsView Dmel\ths in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
pyr and ths show redundancy in the process of mesoderm spreading during gastrulation. pyr is required for formation of cellular protrusions during dorsolateral migration of the mesoderm and for differentiation of pericardial and cardioblast lineages. Other mesodermal lineages, however, require both ths and pyr for their consistent specification.
The genes "pyramus" and "thisbe" are named for the "heartbroken" lovers described in Ovid's Metamorphoses because the genes are linked and the mutant phenotype shows a lack of heart.