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Gene Dmel\S2P

General Information
Symbol	Dmel\S2P	Species	D. melanogaster
Name	site-2 protease	Annotation symbol	CG8988
Feature type	protein_coding_gene	FlyBase ID	FBgn0033656
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	dS2P
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	48C4-48C4	Sequence location	2R:7,729,608..7,731,745 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene site-2 protease is referred to in FlyBase by the symbol Dmel\S2P (CG8988, FBgn0033656). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: metallopeptidase activity. It is reported to be involved in the biological process: sterol regulatory element binding protein cleavage. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase M50; Sterol-regulatory element binding proteins intramembrane protease. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632678_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of S2P. Gene sequence location is 2R:7729608..7731745.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 48C4-48C4   Limits computationally determined from genome sequence between P{EP}walEP825&P{PZ}wal02516 and P{PZ}Ef1α48D01275
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\S2P for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) S2P-RA FBtr0088063  NM_136861   2020   508
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein S2P-PA   FBpp0087169   56.6   508   6.84     NP_610705   AAF58617
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sterol-regulatory element binding proteins intramembrane protease (IPR001193) Peptidase M50 (IPR008915)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391707   AA439767   AA990888   AE013599 AAF58617   AF441757 AAM20921   AI546088   AX094222   AY071529 AAL49151   BF496901   BG638732   BH901022   BI361722   BI370671   BI639584   BI639614   CL844455   CO178744   CO275262   CO276328   CO279007   CO332618   CZ478649   CZ478938   CZ478939   CZ489557   EC054248   EC054324   EC055328   EC060008   EC063609   EC071419   EC216638   EC241770   GH749447   GH750422   GH774677   GH776036   GH786100   GH787149   GH790559   GH794626   GH795470   GH796547   GH798010   GH801223   GH803019   GH803617   GH807953   GH812050   GH814337   GH815658   GH817609   GH820514   GH822436   GH827714   GH834538   GH836602   GH837619   GH841137   GH847441   GH848293   GH850702   GH851629   GH854723   GH854726   GH855599   GH857232   GH861662   GH862969   GH864986   GH870974   GH877747   GH882659   GH887533   GH887679   GH889342   GH896091   GH897899   GH901440   GH902776   GH906851   GH911380   GH914838   GH917389   GH932456   GH934078   GH936682   GH942452
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JZ56
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    177.175 Larval Midgut    79 Larval Hindgut    98.6 Larval Malpighian Tubules    134.9 Larval Fat Body    110.2 Larval Salivary Gland    113 Larval Trachea    162.975 Larval Carcass    117.1 Adult Head    82.5 Adult Eye    77.05 Adult Brain    117 Adult Thoracic-Abdominal Ganglion    161.8 Adult Crop    122.3 Adult Midgut    58.3 Adult Hindgut    69.7 Adult Malpighian Tubules    154.1 Adult Fat Body    139 Adult Salivary Gland    108 Adult Heart    120.4 Adult VirginFemale Spermatheca    146.5 Adult InseminatedFemale Spermatheca    159.1 Adult Ovary    167.5 Adult Testis    144.1 Adult Male Accessory Gland    147.3 Adult Carcass    119.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    177.175 Larval Midgut    79 Larval Hindgut    98.6 Larval Malpighian Tubules    134.9 Larval Fat Body    110.2 Larval Salivary Gland    113 Larval Trachea    162.975 Larval Carcass    117.1 Adult Head    82.5 Adult Eye    77.05 Adult Brain    117 Adult Thoracic-Abdominal Ganglion    161.8 Adult Crop    122.3 Adult Midgut    58.3 Adult Hindgut    69.7 Adult Malpighian Tubules    154.1 Adult Fat Body    139 Adult Salivary Gland    108 Adult Heart    120.4 Adult VirginFemale Spermatheca    146.5 Adult InseminatedFemale Spermatheca    159.1 Adult Ovary    167.5 Adult Testis    144.1 Adult Male Accessory Gland    147.3 Adult Carcass    119.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    177.175 Larval Midgut    79 Larval Hindgut    98.6 Larval Malpighian Tubules    134.9 Larval Fat Body    110.2 Larval Salivary Gland    113 Larval Trachea    162.975 Larval Carcass    117.1 Adult Head    82.5 Adult Eye    77.05 Adult Brain    117 Adult Thoracic-Abdominal Ganglion    161.8 Adult Crop    122.3 Adult Midgut    58.3 Adult Hindgut    69.7 Adult Malpighian Tubules    154.1 Adult Fat Body    139 Adult Salivary Gland    108 Adult Heart    120.4 Adult VirginFemale Spermatheca    146.5 Adult InseminatedFemale Spermatheca    159.1 Adult Ovary    167.5 Adult Testis    144.1 Adult Male Accessory Gland    147.3 Adult Carcass    119.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    177.175 Larval Midgut    79 Larval Hindgut    98.6 Larval Malpighian Tubules    134.9 Larval Fat Body    110.2 Larval Salivary Gland    113 Larval Trachea    162.975 Larval Carcass    117.1 Adult Head    82.5 Adult Eye    77.05 Adult Brain    117 Adult Thoracic-Abdominal Ganglion    161.8 Adult Crop    122.3 Adult Midgut    58.3 Adult Hindgut    69.7 Adult Malpighian Tubules    154.1 Adult Fat Body    139 Adult Salivary Gland    108 Adult Heart    120.4 Adult VirginFemale Spermatheca    146.5 Adult InseminatedFemale Spermatheca    159.1 Adult Ovary    167.5 Adult Testis    144.1 Adult Male Accessory Gland    147.3 Adult Carcass    119.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    177.175 Larval Midgut    79 Larval Hindgut    98.6 Larval Malpighian Tubules    134.9 Larval Fat Body    110.2 Larval Salivary Gland    113 Larval Trachea    162.975 Larval Carcass    117.1 Adult Head    82.5 Adult Eye    77.05 Adult Brain    117 Adult Thoracic-Abdominal Ganglion    161.8 Adult Crop    122.3 Adult Midgut    58.3 Adult Hindgut    69.7 Adult Malpighian Tubules    154.1 Adult Fat Body    139 Adult Salivary Gland    108 Adult Heart    120.4 Adult VirginFemale Spermatheca    146.5 Adult InseminatedFemale Spermatheca    159.1 Adult Ovary    167.5 Adult Testis    144.1 Adult Male Accessory Gland    147.3 Adult Carcass    119.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    177.175 Larval Midgut    79 Larval Hindgut    98.6 Larval Malpighian Tubules    134.9 Larval Fat Body    110.2 Larval Salivary Gland    113 Larval Trachea    162.975 Larval Carcass    117.1 Adult Head    82.5 Adult Eye    77.05 Adult Brain    117 Adult Thoracic-Abdominal Ganglion    161.8 Adult Crop    122.3 Adult Midgut    58.3 Adult Hindgut    69.7 Adult Malpighian Tubules    154.1 Adult Fat Body    139 Adult Salivary Gland    108 Adult Heart    120.4 Adult VirginFemale Spermatheca    146.5 Adult InseminatedFemale Spermatheca    159.1 Adult Ovary    167.5 Adult Testis    144.1 Adult Male Accessory Gland    147.3 Adult Carcass    119.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    177.175 Larval Midgut    79 Larval Hindgut    98.6 Larval Malpighian Tubules    134.9 Larval Fat Body    110.2 Larval Salivary Gland    113 Larval Trachea    162.975 Larval Carcass    117.1 Adult Head    82.5 Adult Eye    77.05 Adult Brain    117 Adult Thoracic-Abdominal Ganglion    161.8 Adult Crop    122.3 Adult Midgut    58.3 Adult Hindgut    69.7 Adult Malpighian Tubules    154.1 Adult Fat Body    139 Adult Salivary Gland    108 Adult Heart    120.4 Adult VirginFemale Spermatheca    146.5 Adult InseminatedFemale Spermatheca    159.1 Adult Ovary    167.5 Adult Testis    144.1 Adult Male Accessory Gland    147.3 Adult Carcass    119.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    177.175 Larval Midgut    79 Larval Hindgut    98.6 Larval Malpighian Tubules    134.9 Larval Fat Body    110.2 Larval Salivary Gland    113 Larval Trachea    162.975 Larval Carcass    117.1 Adult Head    82.5 Adult Eye    77.05 Adult Brain    117 Adult Thoracic-Abdominal Ganglion    161.8 Adult Crop    122.3 Adult Midgut    58.3 Adult Hindgut    69.7 Adult Malpighian Tubules    154.1 Adult Fat Body    139 Adult Salivary Gland    108 Adult Heart    120.4 Adult VirginFemale Spermatheca    146.5 Adult InseminatedFemale Spermatheca    159.1 Adult Ovary    167.5 Adult Testis    144.1 Adult Male Accessory Gland    147.3 Adult Carcass    119.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    82.5   NA  Eye    77.05   NA  Brain    117   177.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    161.8   NA  Crop    122.3   79  Midgut    58.3   98.6  Hindgut    69.7   134.9  Malpighian Tubules    154.1   110.2  Fat Body    139   113  Salivary Gland    108   NA  Heart    120.4   162.975  Trachea    NA   NA  VirginFemale Spermatheca    146.5   NA  InseminatedFemale Spermatheca    159.1   NA  Ovary    167.5   NA  Testis    144.1   NA  Male Accessory Gland    147.3   117.1  Carcass    119.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    29 ovary, mated 4-day female    24 testis, mated 4-day male    21 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female  (29) ovary, mated 4-day female    24 testis, mated 4-day male    21 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    29 ovary, mated 4-day female    24 testis, mated 4-day male    21 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    29 ovary, mated 4-day female    24 testis, mated 4-day male    21 accessory gland, mated 4-day male    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    29 ovary, mated 4-day female    24 testis, mated 4-day male    21 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female  29 ovary, mated 4-day female    24 testis, mated 4-day male    21 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    29 ovary, mated 4-day female    24 testis, mated 4-day male    21 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    29 ovary, mated 4-day female    24 testis, mated 4-day male    21 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    47 embryo 04-06hr    11 embryo 06-08hr    8 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    10 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    24 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    15 adult male 05day    16 adult male 30day    17 adult female 01day    20 adult female 05day    31 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (47) embryo 02-04hr  (47) embryo 04-06hr    11 embryo 06-08hr    8 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    10 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    24 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    15 adult male 05day    16 adult male 30day    17 adult female 01day    20 adult female 05day  (31) adult female 30day  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    47 embryo 04-06hr    11 embryo 06-08hr    8 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    10 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    24 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    15 adult male 05day    16 adult male 30day    17 adult female 01day    20 adult female 05day    31 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    47 embryo 04-06hr    11 embryo 06-08hr    8 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    10 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    24 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    15 adult male 05day    16 adult male 30day    17 adult female 01day    20 adult female 05day    31 adult female 30day    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    47 embryo 04-06hr    11 embryo 06-08hr    8 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    10 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    24 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    15 adult male 05day    16 adult male 30day    17 adult female 01day    20 adult female 05day    31 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (47) embryo 02-04hr  (47) embryo 04-06hr    11 embryo 06-08hr    8 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    10 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    24 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    15 adult male 05day    16 adult male 30day    17 adult female 01day    20 adult female 05day  31 adult female 30day  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    47 embryo 04-06hr    11 embryo 06-08hr    8 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    10 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    24 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    15 adult male 05day    16 adult male 30day    17 adult female 01day    20 adult female 05day    31 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    47 embryo 04-06hr    11 embryo 06-08hr    8 embryo 08-10hr    14 embryo 10-12hr    16 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    10 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    20 white prepupae 24hr    24 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    10 adult male 01day    15 adult male 05day    16 adult male 30day    17 adult female 01day    20 adult female 05day    31 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    50 Schneider line 2 Sg4    20 embryonic 1182-4H    39 embryonic GM2    37 embryonic Kc167    37 embryonic S1    42 embryonic S3    48 leg disc CME L1    19 wing disc CME-W2    29 wing disc ML-DmD8    17 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    29 wing disc ML-DmD32    47 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    37 ovary fGS/OSS    20 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (50) Schneider line 2 Sg4    20 embryonic 1182-4H  (39) embryonic GM2  (37) embryonic Kc167  (37) embryonic S1  (42) embryonic S3  (48) leg disc CME L1    19 wing disc CME-W2  (29) wing disc ML-DmD8    17 wing disc ML-DmD9  (30) wing disc ML-DmD16-c3  (27) wing disc ML-DmD21  (29) wing disc ML-DmD32  (47) haltere disc ML-DmD17-c3  (29) eye-antennal disc ML-DmD11  (32) antennal disc ML-DmD20-c5  26 mixed discs ML-DmD4-c1  (28) CNS ML-DmBG1-c1  (34) CNS ML-DmBG2-c2  (69) tumorous blood cells mbn2  (37) ovary fGS/OSS    20 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    50 Schneider line 2 Sg4    20 embryonic 1182-4H    39 embryonic GM2    37 embryonic Kc167    37 embryonic S1    42 embryonic S3    48 leg disc CME L1    19 wing disc CME-W2    29 wing disc ML-DmD8    17 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    29 wing disc ML-DmD32    47 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    37 ovary fGS/OSS    20 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    50 Schneider line 2 Sg4    20 embryonic 1182-4H    39 embryonic GM2    37 embryonic Kc167    37 embryonic S1    42 embryonic S3    48 leg disc CME L1    19 wing disc CME-W2    29 wing disc ML-DmD8    17 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    29 wing disc ML-DmD32    47 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    37 ovary fGS/OSS    20 ovary OSC    17 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    50 Schneider line 2 Sg4    20 embryonic 1182-4H    39 embryonic GM2    37 embryonic Kc167    37 embryonic S1    42 embryonic S3    48 leg disc CME L1    19 wing disc CME-W2    29 wing disc ML-DmD8    17 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    29 wing disc ML-DmD32    47 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    37 ovary fGS/OSS    20 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (50) Schneider line 2 Sg4    20 embryonic 1182-4H  (39) embryonic GM2  (37) embryonic Kc167  (37) embryonic S1  (42) embryonic S3  (48) leg disc CME L1    19 wing disc CME-W2  29 wing disc ML-DmD8    17 wing disc ML-DmD9  30 wing disc ML-DmD16-c3  27 wing disc ML-DmD21  29 wing disc ML-DmD32  (47) haltere disc ML-DmD17-c3  29 eye-antennal disc ML-DmD11  32 antennal disc ML-DmD20-c5  26 mixed discs ML-DmD4-c1  28 CNS ML-DmBG1-c1  (34) CNS ML-DmBG2-c2  (69) tumorous blood cells mbn2  (37) ovary fGS/OSS    20 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    50 Schneider line 2 Sg4    20 embryonic 1182-4H    39 embryonic GM2    37 embryonic Kc167    37 embryonic S1    42 embryonic S3    48 leg disc CME L1    19 wing disc CME-W2    29 wing disc ML-DmD8    17 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    29 wing disc ML-DmD32    47 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    37 ovary fGS/OSS    20 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    50 Schneider line 2 Sg4    20 embryonic 1182-4H    39 embryonic GM2    37 embryonic Kc167    37 embryonic S1    42 embryonic S3    48 leg disc CME L1    19 wing disc CME-W2    29 wing disc ML-DmD8    17 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    29 wing disc ML-DmD32    47 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    34 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    37 ovary fGS/OSS    20 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033656 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8988-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage (with S2P1) S2PKG08356 lethal | larval stage (with S2PKG08356) S2P1 viable S2P1 S2PEY11387 viable, with Scer\GAL4pnr-MD237 S2PGD1939 viable | conditional S2P1 S2PKG08356 viable | conditional (with S2P1) S2PKG08356 viable | conditional (with S2PKG08356) S2P1 Sterility Allele fertile S2PEY11387 Other Phenotypes Allele small body (with S2P1) S2PKG08356 small body (with S2PKG08356) S2P1 Phenotype manifest in Allele
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of S2P Class Mutagen Stocks Known lesion S2P1 P-element activity 1 Yes S2Pe00805 piggyBac transposase 1 -- S2Pe01121 piggyBac transposase 1 -- S2PEY11387 P-element activity 1 -- S2Pf06830 piggyBac transposase 1 -- S2PKG08356 P-element activity 1 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of S2P Class Mutagen Stocks Known lesion S2PGD1939 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes S2PHMS01508 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes S2PKK102025 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)S2P-1 (Matthews et al., 2009) Df(2R)ths238 (Kadam et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1939} NA P{KK102025} NA P{TRiP.HMS01508} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}KG07804 NA P{SUPor-P}S2PKG08356 NA PBac{RB}S2Pe00805 NA PBac{RB}S2Pe01121 NA PBac{WH}S2Pf06830 NA insertion of mobile activating element P{EPgy2}S2PEY11387 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
metalloendopeptidase activity inferred from electronic annotation with InterPro:IPR001193, InterPro:IPR008915 (FlyBase Curators et al., 2004-) non-traceable author statement (Seegmiller, 2001.11.1) metallopeptidase activity inferred from sequence or structural similarity with UniProtKB:O43462 (FlyBase, 1992-)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001193, InterPro:IPR008915 (FlyBase Curators et al., 2004-) sterol regulatory element binding protein cleavage non-traceable author statement (Rawson, 2003)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR001193 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions S2P allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62048 DroID - A comprehensive database of gene and protein interactions. • FBgn0033656 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36262
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6868Z5 Dipteran inclusive ortholog search EOG68GWBK Insect inclusive ortholog search EOG615F8R Arthropod inclusive ortholog search EOG60ZPCZ Metazoa inclusive ortholog search EOG6HB9CV
Orthologs in Drosophila Species (EOG6868Z5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\S2P     Drosophila simulans   Dsim\GD25883 Y   Drosophila sechellia   Dsec\GM20407 Y   Drosophila erecta   Dere\GG22629 Y   Drosophila yakuba   Dyak\GE13498 Y   Drosophila ananassae   Dana\GF13403 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21457 Y   Drosophila persimilis   Dper\GL10249 Y   Drosophila willistoni   Dwil\GK17918 Y   Drosophila virilis   Dvir\GJ20871 Y   Drosophila mojavensis   Dmoj\GI21268 Y   Drosophila grimshawi   Dgri\GH22883 Y
Orthologs in non-Drosophila Dipterans (EOG68GWBK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013482   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012324   Anopheles gambiae Malaria mosquito  Agam\AGAP011819   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010386
Orthologs in non-Dipteran Insects (EOG615F8R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC724553   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG031884   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007942   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG021487   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22159   Atta cephalotes Leafcutter ant  Acep\ACEP14841   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22329   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19965   Linepithema humile Argentine ant  Lhum\LH16142   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20016   Solenopsis invicta Red fire ant  Sinv\SINV15405   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003362   Pediculus humanus Human body louse  Phum\PHUM599380   Tribolium castaneum Red flour beetle  Tcas\TC000469
Orthologs in non-Insect Arthropods (EOG60ZPCZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Rpb4   Ixodes scapularis Deer tick  Isca\ISCW019725
Orthologs in non-Arthropod Metazoa (EOG6HB9CV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y56A3A.2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001178gn   Danio rerio Zebrafish  Drer\mbtps2   Xenopus tropicalis Western clawed frog  Xtro\mbtps2   Gallus gallus Domestic chicken  Ggal\MBTPS2   Mus musculus House mouse  Mmus\Mbtps2   Rattus norvegicus Norway rat  Rnor\Mbtps2   Homo sapiens Human  Hsap\MBTPS2
Human Orthologs (1)
Gene OMIM HGNC Hsap\MBTPS2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25883 Drosophila sechellia Dsec\GM20407 Drosophila erecta Dere\GG22629 Drosophila yakuba Dyak\GE13498 Drosophila ananassae Dana\GF13403 Drosophila pseudoobscura pseudoobscura Dpse\GA21457 Drosophila persimilis Dper\GL10249 Drosophila willistoni Dwil\GK17918 Drosophila virilis Dvir\GJ20871 Drosophila mojavensis Dmoj\GI21268 Drosophila grimshawi Dgri\GH22883
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	20306 y1 w67c23; P{EPgy2}S2PEY11387 14717 y1 w67c23; P{SUPor-P}S2PKG08356 35760 y1 sc* v1; P{TRiP.HMS01508}attP2 38392 w*; S2P1/CyO, P{ActGFP}JMR1; HLH106189/TM6B, Tb+
Harvard	- PBac{RB}S2Pe00805 - PBac{RB}S2Pe01121 - PBac{WH}S2Pf06830
VDRC	v4601 w1118; P{GD1939}v4601/TM3
Genomic Clones ( 1 )
	BACR26P21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 77 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE57384
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10907 LD11632 LD14421 LD39580 RE46054 SD22212 SD22245
Other clones	71596 277240 CK01.72C.F4 CK01.141A.B8 CK01.146C.C6 EC054248 EC054324 EC055328 EK057454 EK116940 EK120443 EK132806 EK304047 LD34294 RP003013933 RP003048599 RP003054870 RP003060770 RP003066766 RP003068648 RP003068686 RP003075828 RP003079313 RP003093154 RP003102934 RP003115150 RP003122752 RP003145128 RP003145832 RP003152094 RP003162498 RP003173050 RP003178414 RP003179631 RP003193828 RP003198849 RP003224421 RP003228896 RP003255207 RP003260986 RP003267136 RP003326834 RP003355927 RP003372748 RP003410365 RP003435357 RP003443647 RP003456893 RP003468002 RP003486106 RP003488894 RP003498205 RP003510776 RP003535392 RP003535769 RP003541239 RP003546990 RP003550450 RP003551760 RP003558401 RP003581266 RP003604394 RP003641103 RP003643211 RP003645998 RP003651979 RP003666709 RP003679171 RP003682816
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033656 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36262
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: S2P CG8988 (FlyBase, 1996-)
Source for database merge of	Source for merge of: S2P anon-WO0118547.346 (FlyBase, 1996-)
Additional comments	Source for merge of S2P anon-WO0118547.346 was sequence comparison (date:051113). (FlyBase, 1996-) Source for identity of S2P CG8988 was sequence comparison (date:020504). (FlyBase, 1996-)
Other Comments
	Area matching Drosophila EST AA391707. Probable intron in gene represented by EST AA391707. (Davies, 2001.3.15) Corresponds to clone: LD14422 (Seegmiller, 2001.11.1)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136861 RefSeq (Proteins) • NP_610705 DDBJ / EMBL / GenBank • AA391707 AAF58617 AAL49151 AAM20921 AF441757 AX094222 AY071529 BH901022 BI370671 CL844455 CZ478649 CZ478938 CZ478939 CZ489557 Entrez Gene - A searchable database of RefSeq genes. • 36262 UniProtKB/TrEMBL • Q7JZ56
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sterol-regulatory element binding proteins intramembrane protease (IPR001193) Peptidase M50 (IPR008915)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62048 DroID - A comprehensive database of gene and protein interactions. • FBgn0033656 DRSC - Results from RNAi screens. • FBgn0033656 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033656 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8988-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033656 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36262 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36262 modMine - Data generated by the modENCODE project. • FBgn0033656
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	anon-WO0118547.346   CG8988 (Seegmiller et al., 2002, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dS2P (Rawson, 2003, Seegmiller, 2001.11.1, Seegmiller et al., 2002, Matthews et al., 2009, Amarneh et al., 2009) ds2p (Ozdemir and Rawson, 2011, Matthews et al., 2010) S2P (Amarneh et al., 2009, Kadam et al., 2009, Casso et al., 2012)
Name Synonym	S2P   site-2 protease (Amarneh et al., 2009)
Secondary FlyBase IDs
	FBgn0062078
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Patent  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Casso et al., 2012, PLoS ONE 7(3): e33827 Expression and Characterization of Drosophila Signal Peptide Peptidase-Like (sppL), a Gene That Encodes an Intramembrane Protease. [FBrf0217861] Ozdemir and Rawson, 2011, Fly 5(1): 3--6 Other ways to skin a cat: Activating SREBP without Scap. [FBrf0212974] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...