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Gene Dmel\Sln

General Information
Symbol	Dmel\Sln	Species	D. melanogaster
Name	Silnoon	Annotation symbol	CG8271
Feature type	protein_coding_gene	FlyBase ID	FBgn0033657
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	48C4-48C5	Sequence location	2R:7,732,831..7,739,829 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Silnoon is referred to in FlyBase by the symbol Dmel\Sln (CG8271, FBgn0033657). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: monocarboxylic acid transmembrane transporter activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: transmembrane transport. 8 alleles are reported. The phenotype of these alleles is annotated with: wing disc. It has one annotated transcript and one annotated polypeptide. Protein features are: Major facilitator superfamily; Major facilitator superfamily domain; Major facilitator superfamily domain, general substrate transporter. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1631649_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Sln. Gene sequence location is 2R:7732831..7739829.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA07133 BKN25266
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 48C4-48C5   Limits computationally determined from genome sequence between P{EP}walEP825&P{PZ}wal02516 and P{PZ}Ef1α48D01275
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sln for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sln-RA FBtr0088032  NM_136862   3916   855
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sln-PA   FBpp0087139   92.2   855   5.13     NP_610706   AAF58616
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Major facilitator superfamily (IPR011701) Major facilitator superfamily domain, general substrate transporter (IPR016196) Major facilitator superfamily domain (IPR020846)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA821242   AE013599 AAF58616   BI161566   BI161567   BI375977   BT016038 AAV36923   CZ481500   EC052402   EC056059
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q5U154
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033657    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033657 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033657 expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    38 embryo 04-06hr    76 embryo 06-08hr    58 embryo 08-10hr    50 embryo 10-12hr    35 embryo 12-14hr    33 embryo 14-16hr    20 embryo 16-18hr    30 embryo 18-20hr    80 embryo 20-22hr    297 embryo 22-24hr    272 larva L1    343 larva L2    111 larva L3 12hr old    38 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    61 white prepupae new    74 white prepupae 12hr    196 white prepupae 24hr    248 pupae 2d postWPP    255 pupae 3d postWPP    232 pupae 4d postWPP    213 adult male 01day    201 adult male 05day    233 adult male 30day    220 adult female 01day    84 adult female 05day    27 adult female 30day    30 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    38 embryo 04-06hr    76 embryo 06-08hr    58 embryo 08-10hr    50 embryo 10-12hr    35 embryo 12-14hr    33 embryo 14-16hr    20 embryo 16-18hr    30 embryo 18-20hr    80 embryo 20-22hr  (297) embryo 22-24hr  (272) larva L1  (343) larva L2  (111) larva L3 12hr old    38 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    61 white prepupae new    74 white prepupae 12hr  (196) white prepupae 24hr  (248) pupae 2d postWPP  (255) pupae 3d postWPP  (232) pupae 4d postWPP  (213) adult male 01day  (201) adult male 05day  (233) adult male 30day  (220) adult female 01day    84 adult female 05day    27 adult female 30day    30 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    38 embryo 04-06hr    76 embryo 06-08hr    58 embryo 08-10hr    50 embryo 10-12hr    35 embryo 12-14hr    33 embryo 14-16hr    20 embryo 16-18hr    30 embryo 18-20hr    80 embryo 20-22hr    297 embryo 22-24hr    272 larva L1    343 larva L2    111 larva L3 12hr old    38 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    61 white prepupae new    74 white prepupae 12hr    196 white prepupae 24hr    248 pupae 2d postWPP    255 pupae 3d postWPP    232 pupae 4d postWPP    213 adult male 01day    201 adult male 05day    233 adult male 30day    220 adult female 01day    84 adult female 05day    27 adult female 30day    30 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    38 embryo 04-06hr    76 embryo 06-08hr    58 embryo 08-10hr    50 embryo 10-12hr    35 embryo 12-14hr    33 embryo 14-16hr    20 embryo 16-18hr    30 embryo 18-20hr    80 embryo 20-22hr    297 embryo 22-24hr    272 larva L1    343 larva L2    111 larva L3 12hr old    38 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    61 white prepupae new    74 white prepupae 12hr    196 white prepupae 24hr    248 pupae 2d postWPP    255 pupae 3d postWPP    232 pupae 4d postWPP    213 adult male 01day    201 adult male 05day    233 adult male 30day    220 adult female 01day    84 adult female 05day    27 adult female 30day    30 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    38 embryo 04-06hr    76 embryo 06-08hr    58 embryo 08-10hr    50 embryo 10-12hr    35 embryo 12-14hr    33 embryo 14-16hr    20 embryo 16-18hr    30 embryo 18-20hr    80 embryo 20-22hr    297 embryo 22-24hr    272 larva L1    343 larva L2    111 larva L3 12hr old    38 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    61 white prepupae new    74 white prepupae 12hr    196 white prepupae 24hr    248 pupae 2d postWPP    255 pupae 3d postWPP    232 pupae 4d postWPP    213 adult male 01day    201 adult male 05day    233 adult male 30day    220 adult female 01day    84 adult female 05day    27 adult female 30day    30 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033657 expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    38 embryo 04-06hr    76 embryo 06-08hr    58 embryo 08-10hr    50 embryo 10-12hr    35 embryo 12-14hr    33 embryo 14-16hr    20 embryo 16-18hr    30 embryo 18-20hr    80 embryo 20-22hr    297 embryo 22-24hr    272 larva L1    343 larva L2    111 larva L3 12hr old    38 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    61 white prepupae new    74 white prepupae 12hr    196 white prepupae 24hr    248 pupae 2d postWPP    255 pupae 3d postWPP    232 pupae 4d postWPP    213 adult male 01day    201 adult male 05day    233 adult male 30day    220 adult female 01day    84 adult female 05day    27 adult female 30day    30 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    38 embryo 04-06hr    76 embryo 06-08hr    58 embryo 08-10hr    50 embryo 10-12hr    35 embryo 12-14hr    33 embryo 14-16hr    20 embryo 16-18hr    30 embryo 18-20hr    80 embryo 20-22hr  (297) embryo 22-24hr  (272) larva L1  (343) larva L2  111 larva L3 12hr old    38 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    61 white prepupae new    74 white prepupae 12hr  (196) white prepupae 24hr  (248) pupae 2d postWPP  (255) pupae 3d postWPP  (232) pupae 4d postWPP  (213) adult male 01day  (201) adult male 05day  (233) adult male 30day  (220) adult female 01day    84 adult female 05day    27 adult female 30day    30 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    38 embryo 04-06hr    76 embryo 06-08hr    58 embryo 08-10hr    50 embryo 10-12hr    35 embryo 12-14hr    33 embryo 14-16hr    20 embryo 16-18hr    30 embryo 18-20hr    80 embryo 20-22hr    297 embryo 22-24hr    272 larva L1    343 larva L2    111 larva L3 12hr old    38 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    61 white prepupae new    74 white prepupae 12hr    196 white prepupae 24hr    248 pupae 2d postWPP    255 pupae 3d postWPP    232 pupae 4d postWPP    213 adult male 01day    201 adult male 05day    233 adult male 30day    220 adult female 01day    84 adult female 05day    27 adult female 30day    30 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    38 embryo 04-06hr    76 embryo 06-08hr    58 embryo 08-10hr    50 embryo 10-12hr    35 embryo 12-14hr    33 embryo 14-16hr    20 embryo 16-18hr    30 embryo 18-20hr    80 embryo 20-22hr    297 embryo 22-24hr    272 larva L1    343 larva L2    111 larva L3 12hr old    38 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    61 white prepupae new    74 white prepupae 12hr    196 white prepupae 24hr    248 pupae 2d postWPP    255 pupae 3d postWPP    232 pupae 4d postWPP    213 adult male 01day    201 adult male 05day    233 adult male 30day    220 adult female 01day    84 adult female 05day    27 adult female 30day    30 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    38 embryo 04-06hr    76 embryo 06-08hr    58 embryo 08-10hr    50 embryo 10-12hr    35 embryo 12-14hr    33 embryo 14-16hr    20 embryo 16-18hr    30 embryo 18-20hr    80 embryo 20-22hr    297 embryo 22-24hr    272 larva L1    343 larva L2    111 larva L3 12hr old    38 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    42 larva L3 puffstage 7-9    61 white prepupae new    74 white prepupae 12hr    196 white prepupae 24hr    248 pupae 2d postWPP    255 pupae 3d postWPP    232 pupae 4d postWPP    213 adult male 01day    201 adult male 05day    233 adult male 30day    220 adult female 01day    84 adult female 05day    27 adult female 30day    30 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033657    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033657 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033657 expression level Tissue   Expression Level Larval Central Nervous System    172.325 Larval Midgut    3.6 Larval Hindgut    5.8 Larval Malpighian Tubules    2.9 Larval Fat Body    2.5 Larval Salivary Gland    5.7 Larval Trachea    3.45 Larval Carcass    6.675 Adult Head    84.5 Adult Eye    34.725 Adult Brain    365.2 Adult Thoracic-Abdominal Ganglion    310 Adult Crop    4.3 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    2.75 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.7 Adult Ovary    2 Adult Testis    18.2 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    172.325 Larval Midgut    3.6 Larval Hindgut    5.8 Larval Malpighian Tubules    2.9 Larval Fat Body    2.5 Larval Salivary Gland    5.7 Larval Trachea    3.45 Larval Carcass    6.675 Adult Head    84.5 Adult Eye    34.725 Adult Brain    365.2 Adult Thoracic-Abdominal Ganglion    310 Adult Crop    4.3 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    2.75 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.7 Adult Ovary    2 Adult Testis    18.2 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    172.325 Larval Midgut    3.6 Larval Hindgut    5.8 Larval Malpighian Tubules    2.9 Larval Fat Body    2.5 Larval Salivary Gland    5.7 Larval Trachea    3.45 Larval Carcass    6.675 Adult Head    84.5 Adult Eye    34.725 Adult Brain    365.2 Adult Thoracic-Abdominal Ganglion    310 Adult Crop    4.3 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    2.75 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.7 Adult Ovary    2 Adult Testis    18.2 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    172.325 Larval Midgut    3.6 Larval Hindgut    5.8 Larval Malpighian Tubules    2.9 Larval Fat Body    2.5 Larval Salivary Gland    5.7 Larval Trachea    3.45 Larval Carcass    6.675 Adult Head    84.5 Adult Eye    34.725 Adult Brain    365.2 Adult Thoracic-Abdominal Ganglion    310 Adult Crop    4.3 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    2.75 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.7 Adult Ovary    2 Adult Testis    18.2 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033657 expression level Tissue   Expression Level Larval Central Nervous System    172.325 Larval Midgut    3.6 Larval Hindgut    5.8 Larval Malpighian Tubules    2.9 Larval Fat Body    2.5 Larval Salivary Gland    5.7 Larval Trachea    3.45 Larval Carcass    6.675 Adult Head    84.5 Adult Eye    34.725 Adult Brain    365.2 Adult Thoracic-Abdominal Ganglion    310 Adult Crop    4.3 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    2.75 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.7 Adult Ovary    2 Adult Testis    18.2 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    172.325 Larval Midgut    3.6 Larval Hindgut    5.8 Larval Malpighian Tubules    2.9 Larval Fat Body    2.5 Larval Salivary Gland    5.7 Larval Trachea    3.45 Larval Carcass    6.675 Adult Head    84.5 Adult Eye    34.725 Adult Brain    365.2 Adult Thoracic-Abdominal Ganglion    310 Adult Crop    4.3 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    2.75 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.7 Adult Ovary    2 Adult Testis    18.2 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    172.325 Larval Midgut    3.6 Larval Hindgut    5.8 Larval Malpighian Tubules    2.9 Larval Fat Body    2.5 Larval Salivary Gland    5.7 Larval Trachea    3.45 Larval Carcass    6.675 Adult Head    84.5 Adult Eye    34.725 Adult Brain    365.2 Adult Thoracic-Abdominal Ganglion    310 Adult Crop    4.3 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    2.75 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.7 Adult Ovary    2 Adult Testis    18.2 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    172.325 Larval Midgut    3.6 Larval Hindgut    5.8 Larval Malpighian Tubules    2.9 Larval Fat Body    2.5 Larval Salivary Gland    5.7 Larval Trachea    3.45 Larval Carcass    6.675 Adult Head    84.5 Adult Eye    34.725 Adult Brain    365.2 Adult Thoracic-Abdominal Ganglion    310 Adult Crop    4.3 Adult Midgut    3.7 Adult Hindgut    5.7 Adult Malpighian Tubules    2.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    2.75 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    2.7 Adult Ovary    2 Adult Testis    18.2 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    84.5   NA  Eye    34.725   NA  Brain    365.2   172.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    310   NA  Crop    4.3   3.6  Midgut    3.7   5.8  Hindgut    5.7   2.9  Malpighian Tubules    2.5   2.5  Fat Body    no informative data   5.7  Salivary Gland    no informative data   NA  Heart    2.75   3.45  Trachea    NA   NA  VirginFemale Spermatheca    1.4   NA  InseminatedFemale Spermatheca    2.7   NA  Ovary    2   NA  Testis    18.2   NA  Male Accessory Gland    6.4   6.675  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033657 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8271-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage SlnD1 lethal | larval stage (with Df(2R)BSC329) SlnD1 lethal | larval stage (with Df(2R)ED2247) SlnD1 viable, with Scer\GAL4pnr-MD237 SlnGD1940 Other Phenotypes Allele increased cell death, with Scer\GAL4e22c Sln6.Scer\UAS.T:Hsap\MYC small body SlnD1 small body (with Df(2R)BSC329) SlnD1 small body (with Df(2R)ED2247) SlnD1 Phenotype manifest in Allele wing disc, with Scer\GAL4e22c Sln6.Scer\UAS.T:Hsap\MYC
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Sln Class Mutagen Stocks Known lesion Slne03749 piggyBac transposase 1 -- SlnD1 loss of function allele Delta2-3 0 Yes SlnEP2245 0 -- SlnG366V.Scer\UAS.T:Hsap\MYC 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sln Class Mutagen Stocks Known lesion SlnGD1940 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Sln6.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes SlndsRNA.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes SlnKK104306 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC329 (Jang et al., 2008) Df(2R)ED2247 (Jang et al., 2008) Df(2R)ths238 (Kadam et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK104306} NA P{UAS-Sln.Sym} NA P{UAS-Sln.WT} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}SlnEP2245 NA miscellaneous insertions PBac{RB}Slne03749 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function
CV term Evidence References
monocarboxylic acid transmembrane transporter activity inferred from direct assay (Jang et al., 2008)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
secondary active monocarboxylate transmembrane transporter activity inferred from sequence or structural similarity with EMBL:AF058054 (FlyBase, 1992-)
Biological Process
CV term Evidence References
transmembrane transport inferred from electronic annotation with InterPro:IPR011701 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR011701 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sln allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62049 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033657 DroID - A comprehensive database of gene and protein interactions. • FBgn0033657 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36263
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11460 Dere\GG20224 Dgri\GH22905 Dmoj\GI18390 Dper\GL10088 Dpse\GA20945 Dsec\GM21309 Dsim\GD10818 Dvir\GJ21467 Dwil\GK17886 Dyak\GE12384
Curated drosophilid orthologs	Dpse\GA20945
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014109-PA Aedes aegypti (mosquito) AAEL014258-PA Aedes aegypti (mosquito) AGAP010881-PA Anopheles gambiae (mosquito) XP_392656.2 Apis mellifera (honey bee) BGIBMGA001691-PA Bombyx mori (silk worm) CAL0000431 Candida albicans (a form of yeast) CAL0000990 Candida albicans (a form of yeast) CAGL0E02035g Candida glabrata (haploid yeast) CPIJ004457 Culex pipens (mosquito) DEHA2E09944g Debaryomyces Hansenii (yeast) 39497 Daphnia pulex (daphnia) KLLA0F03168g Kluyveromyces lactis (yeast) PFB0465c Plasmodium falciparum (protozoal parasite) 81372 Phytophthora ramorum (sudden oak death pathogen) 81773 Phytophthora ramorum (sudden oak death pathogen) 81775 Phytophthora ramorum (sudden oak death pathogen) YOR306C Saccharomyces cerevisiae (budding yeast) Tc00.1047053508397.70 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509885.70 Trypanosoma cruzi (parasitic trypanosome) YALI0C12232g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12640 NV50269 LH10382 FBgn0230130 FBgn0219885 FBgn0208593 FBgn0182581 FBgn0176190 JGI_V11_39497 FBgn0080934 FBgn0147698 FBgn0141129 FBgn0132342 FBgn0130362 FBgn0112415 FBgn0088500 CPIJ004457 BGIBMGA001691 GB18699 AGAP010881 AAEL014258 AAEL014109 PHUM130210
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Harvard	- PBac{RB}Slne03749
VDRC	v4607 w1118; P{GD1940}v4607 v4609 w1118; P{GD1940}v4609
Genomic Clones ( 1 )
	BACR26P21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE01051
Other clones	DPiM_RE01051
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL07967 RE63892
Other clones	EC052402 EC056059
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033657 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36263
Antibody Information
	polyclonal (Jang et al., 2008)
Other Information
Discoverer
Etymology
	'Silnoon' means 'narrow eyes' in Korean. (Jang et al., 2008)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Sln CG8271 (Jang et al., 2008)
Source for database merge of
Additional comments
Other Comments
	BrdU incorporation analysis and phosphohistone H3 immunostaining reveal that Sln expression does not affect G1/S or G2/M cell cycle progression. (Jang et al., 2008) Sln specifically augments lkb1-dependent apoptosis without affecting cell growth and proliferation. (Jang et al., 2008)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136862 RefSeq (Proteins) • NP_610706 DDBJ / EMBL / GenBank • AAF58616 AAV36923 BI161566 BI161567 BT016038 CZ481500 Entrez Gene - A searchable database of RefSeq genes. • 36263 UniProtKB/TrEMBL • Q5U154
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Major facilitator superfamily (IPR011701) Major facilitator superfamily domain, general substrate transporter (IPR016196) Major facilitator superfamily domain (IPR020846)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62049 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0033657 DroID - A comprehensive database of gene and protein interactions. • FBgn0033657 DRSC - Results from RNAi screens. • FBgn0033657 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033657 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8271-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033657 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36263 InParanoid A subset of ortholog calls from InParanoid. • AAEL014109-PA Aedes aegypti (mosquito) AAEL014258-PA Aedes aegypti (mosquito) AGAP010881-PA Anopheles gambiae (mosquito) XP_392656.2 Apis mellifera (honey bee) BGIBMGA001691-PA Bombyx mori (silk worm) CAL0000431 Candida albicans (a form of yeast) CAL0000990 Candida albicans (a form of yeast) CAGL0E02035g Candida glabrata (haploid yeast) CPIJ004457 Culex pipens (mosquito) DEHA2E09944g Debaryomyces Hansenii (yeast) 39497 Daphnia pulex (daphnia) KLLA0F03168g Kluyveromyces lactis (yeast) PFB0465c Plasmodium falciparum (protozoal parasite) 81372 Phytophthora ramorum (sudden oak death pathogen) 81773 Phytophthora ramorum (sudden oak death pathogen) 81775 Phytophthora ramorum (sudden oak death pathogen) YOR306C Saccharomyces cerevisiae (budding yeast) Tc00.1047053508397.70 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509885.70 Trypanosoma cruzi (parasitic trypanosome) YALI0C12232g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36263 modMine - Data generated by the modENCODE project. • FBgn0033657 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12640 NV50269 LH10382 FBgn0230130 FBgn0219885 FBgn0208593 FBgn0182581 FBgn0176190 JGI_V11_39497 FBgn0080934 FBgn0147698 FBgn0141129 FBgn0132342 FBgn0130362 FBgn0112415 FBgn0088500 CPIJ004457 BGIBMGA001691 GB18699 AGAP010881 AAEL014258 AAEL014109 PHUM130210
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG8271 (Jang et al., 2008, Matthews et al., 2009, Kadam et al., 2009, Li et al., 2007, Keleman et al., 2009.8.5) Sln (Jang et al., 2008)
Name Synonym	CG8271   Silnoon (Jang et al., 2008)
Secondary FlyBase IDs
References ( 17 )
Research paper	Kadam et al., 2009, Development 136(5): 739--747 FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation. [FBrf0206790] Matthews et al., 2009, Genetics 181(1): 119--128 Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster. [FBrf0206893] Jang et al., 2008, J. Cell Biol. 183(1): 11--17 LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster. [FBrf0205966] Li et al., 2007, J. Biol. Chem. 282(52): 37605--37617 Identification and characterization of a juvenile hormone response element and its binding proteins. [FBrf0202965] Stathopoulos et al., 2004, Genes Dev. 18(6): 687--699 pyramus and thisbe: fGF genes that pattern the mesoderm of Drosophila embryos. [FBrf0174649]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126677]