Gene model reviewed during 5.42
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Interacts with ntc. Interacts with Tnks (via ANK repeats). Interacts with 20S proteasome subunits Prosalpha1, Prosalpha3, Prosalpha4 and Prosalpha6, but not with Prosalpha2 and Prosalpha5. The interaction with Prosalpha4 is reduced by PI31 ADP-ribosylation. Interacts with the 19S assembly chaperones PSMD5 and PSMD9; these interactions are increased by PI31 ADP-ribosylation.
ADP-ribosylation by Tnks increases its affinity for assembly chaperones PSMD9 and PMSD5, sequestering them away from the proteasome Rpt base subunits and promoting in this way 26S proteasome assembly. Also interferes with its inhibitory effect on 20S proteasome.
The Hydrophobic-Tyrosine-X (HbYX) motif is involved in proteasome activation.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PI31 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\PI31 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: PI31 CG8979