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Gene Dmel\rho-7

General Information
Symbol	Dmel\rho-7	Species	D. melanogaster
Name	rhomboid-7	Annotation symbol	CG8972
Feature type	protein_coding_gene	FlyBase ID	FBgn0033672
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	48D5-48D5	Sequence location	2R:7,874,223..7,876,261 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene rhomboid-7 is referred to in FlyBase by the symbol Dmel\rho-7 (CG8972, FBgn0033672). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: serine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process: mitochondrial fusion. 6 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; Nebenkern; testis; eye photoreceptor cell; mitochondrion; seminal vesicle; indirect flight muscle; spermatozoon. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase S54, rhomboid; Peptidase S54, rhomboid domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627697_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of rho-7. Gene sequence location is 2R:7874223..7876261.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA07304 BKN27598
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 48D5-48D5   Limits computationally determined from genome sequence between P{lacW}l(2)k06612k06612 and P{lacW}jebk05644
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\rho-7 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) rho-7-RA FBtr0088045  NM_078980   1297   351
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein rho-7-PA   FBpp0087151   38.9   351   10.30     NP_523704   AAF58598
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S54, rhomboid (IPR002610) Peptidase S54, rhomboid domain (IPR022764)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58598   AI387069   AX153652   AY122236 AAM52748   BI625846   BP545861   CO178494   CO191329   CO270055   CO284868   CO329295   CO342469   EC059734   EC090175   EC254849   EL879628   EL881530   EL886413   EL886530   EL886637   GH942932   GH943192   GH948593   GH948692   GH954982   GH970221   GH971976   GH973651   GH978036   GH980252   GH980934   GH982268   GH982315   GH982911
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MQY3 A1Z8R8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0033672    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0033672 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0033672 expression level Developmental Stage   Expression Level embryo 00-02hr    3166 embryo 02-04hr    1843 embryo 04-06hr    2244 embryo 06-08hr    2312 embryo 08-10hr    2196 embryo 10-12hr    3036 embryo 12-14hr    1863 embryo 14-16hr    2129 embryo 16-18hr    1880 embryo 18-20hr    1730 embryo 20-22hr    1604 embryo 22-24hr    1544 larva L1    2421 larva L2    2815 larva L3 12hr old    2283 larva L3 puffstage 1-2    1742 larva L3 puffstage 3-6    1861 larva L3 puffstage 7-9    2198 white prepupae new    2033 white prepupae 12hr    2005 white prepupae 24hr    2728 pupae 2d postWPP    3054 pupae 3d postWPP    2594 pupae 4d postWPP    2104 adult male 01day    2814 adult male 05day    3537 adult male 30day    4008 adult female 01day    2147 adult female 05day    2620 adult female 30day    2684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3166) embryo 02-04hr  (1843) embryo 04-06hr  (2244) embryo 06-08hr  (2312) embryo 08-10hr  (2196) embryo 10-12hr  (3036) embryo 12-14hr  (1863) embryo 14-16hr  (2129) embryo 16-18hr  (1880) embryo 18-20hr  (1730) embryo 20-22hr  (1604) embryo 22-24hr  (1544) larva L1  (2421) larva L2  (2815) larva L3 12hr old  (2283) larva L3 puffstage 1-2  (1742) larva L3 puffstage 3-6  (1861) larva L3 puffstage 7-9  (2198) white prepupae new  (2033) white prepupae 12hr  (2005) white prepupae 24hr  (2728) pupae 2d postWPP  (3054) pupae 3d postWPP  (2594) pupae 4d postWPP  (2104) adult male 01day  (2814) adult male 05day  (3537) adult male 30day  (4008) adult female 01day  (2147) adult female 05day  (2620) adult female 30day  (2684) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3166) embryo 02-04hr  (1843) embryo 04-06hr  (2244) embryo 06-08hr  (2312) embryo 08-10hr  (2196) embryo 10-12hr  (3036) embryo 12-14hr  (1863) embryo 14-16hr  (2129) embryo 16-18hr  (1880) embryo 18-20hr  (1730) embryo 20-22hr  (1604) embryo 22-24hr  (1544) larva L1  (2421) larva L2  (2815) larva L3 12hr old  (2283) larva L3 puffstage 1-2  (1742) larva L3 puffstage 3-6  (1861) larva L3 puffstage 7-9  (2198) white prepupae new  (2033) white prepupae 12hr  (2005) white prepupae 24hr  (2728) pupae 2d postWPP  (3054) pupae 3d postWPP  (2594) pupae 4d postWPP  (2104) adult male 01day  (2814) adult male 05day  (3537) adult male 30day  (4008) adult female 01day  (2147) adult female 05day  (2620) adult female 30day  (2684) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3166 embryo 02-04hr    1843 embryo 04-06hr    2244 embryo 06-08hr    2312 embryo 08-10hr    2196 embryo 10-12hr    3036 embryo 12-14hr    1863 embryo 14-16hr    2129 embryo 16-18hr    1880 embryo 18-20hr    1730 embryo 20-22hr    1604 embryo 22-24hr    1544 larva L1    2421 larva L2    2815 larva L3 12hr old    2283 larva L3 puffstage 1-2    1742 larva L3 puffstage 3-6    1861 larva L3 puffstage 7-9    2198 white prepupae new    2033 white prepupae 12hr    2005 white prepupae 24hr    2728 pupae 2d postWPP    3054 pupae 3d postWPP    2594 pupae 4d postWPP    2104 adult male 01day    2814 adult male 05day    3537 adult male 30day    4008 adult female 01day    2147 adult female 05day    2620 adult female 30day    2684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3166 embryo 02-04hr    1843 embryo 04-06hr    2244 embryo 06-08hr    2312 embryo 08-10hr    2196 embryo 10-12hr    3036 embryo 12-14hr    1863 embryo 14-16hr    2129 embryo 16-18hr    1880 embryo 18-20hr    1730 embryo 20-22hr    1604 embryo 22-24hr    1544 larva L1    2421 larva L2    2815 larva L3 12hr old    2283 larva L3 puffstage 1-2    1742 larva L3 puffstage 3-6    1861 larva L3 puffstage 7-9    2198 white prepupae new    2033 white prepupae 12hr    2005 white prepupae 24hr    2728 pupae 2d postWPP    3054 pupae 3d postWPP    2594 pupae 4d postWPP    2104 adult male 01day    2814 adult male 05day    3537 adult male 30day    4008 adult female 01day    2147 adult female 05day    2620 adult female 30day    2684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0033672 expression level Developmental Stage   Expression Level embryo 00-02hr    3166 embryo 02-04hr    1843 embryo 04-06hr    2244 embryo 06-08hr    2312 embryo 08-10hr    2196 embryo 10-12hr    3036 embryo 12-14hr    1863 embryo 14-16hr    2129 embryo 16-18hr    1880 embryo 18-20hr    1730 embryo 20-22hr    1604 embryo 22-24hr    1544 larva L1    2421 larva L2    2815 larva L3 12hr old    2283 larva L3 puffstage 1-2    1742 larva L3 puffstage 3-6    1861 larva L3 puffstage 7-9    2198 white prepupae new    2033 white prepupae 12hr    2005 white prepupae 24hr    2728 pupae 2d postWPP    3054 pupae 3d postWPP    2594 pupae 4d postWPP    2104 adult male 01day    2814 adult male 05day    3537 adult male 30day    4008 adult female 01day    2147 adult female 05day    2620 adult female 30day    2684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3166) embryo 02-04hr  (1843) embryo 04-06hr  (2244) embryo 06-08hr  (2312) embryo 08-10hr  (2196) embryo 10-12hr  (3036) embryo 12-14hr  (1863) embryo 14-16hr  (2129) embryo 16-18hr  (1880) embryo 18-20hr  (1730) embryo 20-22hr  (1604) embryo 22-24hr  (1544) larva L1  (2421) larva L2  (2815) larva L3 12hr old  (2283) larva L3 puffstage 1-2  (1742) larva L3 puffstage 3-6  (1861) larva L3 puffstage 7-9  (2198) white prepupae new  (2033) white prepupae 12hr  (2005) white prepupae 24hr  (2728) pupae 2d postWPP  (3054) pupae 3d postWPP  (2594) pupae 4d postWPP  (2104) adult male 01day  (2814) adult male 05day  (3537) adult male 30day  (4008) adult female 01day  (2147) adult female 05day  (2620) adult female 30day  (2684) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3166) embryo 02-04hr  1843 embryo 04-06hr  2244 embryo 06-08hr  2312 embryo 08-10hr  2196 embryo 10-12hr  (3036) embryo 12-14hr  1863 embryo 14-16hr  2129 embryo 16-18hr  1880 embryo 18-20hr  1730 embryo 20-22hr  1604 embryo 22-24hr  1544 larva L1  2421 larva L2  (2815) larva L3 12hr old  2283 larva L3 puffstage 1-2  1742 larva L3 puffstage 3-6  1861 larva L3 puffstage 7-9  2198 white prepupae new  2033 white prepupae 12hr  2005 white prepupae 24hr  (2728) pupae 2d postWPP  (3054) pupae 3d postWPP  (2594) pupae 4d postWPP  2104 adult male 01day  (2814) adult male 05day  (3537) adult male 30day  (4008) adult female 01day  2147 adult female 05day  (2620) adult female 30day  (2684) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3166 embryo 02-04hr    1843 embryo 04-06hr    2244 embryo 06-08hr    2312 embryo 08-10hr    2196 embryo 10-12hr    3036 embryo 12-14hr    1863 embryo 14-16hr    2129 embryo 16-18hr    1880 embryo 18-20hr    1730 embryo 20-22hr    1604 embryo 22-24hr    1544 larva L1    2421 larva L2    2815 larva L3 12hr old    2283 larva L3 puffstage 1-2    1742 larva L3 puffstage 3-6    1861 larva L3 puffstage 7-9    2198 white prepupae new    2033 white prepupae 12hr    2005 white prepupae 24hr    2728 pupae 2d postWPP    3054 pupae 3d postWPP    2594 pupae 4d postWPP    2104 adult male 01day    2814 adult male 05day    3537 adult male 30day    4008 adult female 01day    2147 adult female 05day    2620 adult female 30day    2684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3166 embryo 02-04hr    1843 embryo 04-06hr    2244 embryo 06-08hr    2312 embryo 08-10hr    2196 embryo 10-12hr    3036 embryo 12-14hr    1863 embryo 14-16hr    2129 embryo 16-18hr    1880 embryo 18-20hr    1730 embryo 20-22hr    1604 embryo 22-24hr    1544 larva L1    2421 larva L2    2815 larva L3 12hr old    2283 larva L3 puffstage 1-2    1742 larva L3 puffstage 3-6    1861 larva L3 puffstage 7-9    2198 white prepupae new    2033 white prepupae 12hr    2005 white prepupae 24hr    2728 pupae 2d postWPP    3054 pupae 3d postWPP    2594 pupae 4d postWPP    2104 adult male 01day    2814 adult male 05day    3537 adult male 30day    4008 adult female 01day    2147 adult female 05day    2620 adult female 30day    2684 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0033672    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0033672 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0033672 expression level Tissue   Expression Level Larval Central Nervous System    145.975 Larval Midgut    162.1 Larval Hindgut    157.7 Larval Malpighian Tubules    181.9 Larval Fat Body    156.7 Larval Salivary Gland    217 Larval Trachea    165.05 Larval Carcass    126.45 Adult Head    127.2 Adult Eye    200.775 Adult Brain    208.8 Adult Thoracic-Abdominal Ganglion    181.2 Adult Crop    98.8 Adult Midgut    133.1 Adult Hindgut    132.8 Adult Malpighian Tubules    146.6 Adult Fat Body    118.6 Adult Salivary Gland    148.4 Adult Heart    120.775 Adult VirginFemale Spermatheca    131.9 Adult InseminatedFemale Spermatheca    125 Adult Ovary    178.1 Adult Testis    426 Adult Male Accessory Gland    152.6 Adult Carcass    124.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    145.975 Larval Midgut    162.1 Larval Hindgut    157.7 Larval Malpighian Tubules    181.9 Larval Fat Body    156.7 Larval Salivary Gland    217 Larval Trachea    165.05 Larval Carcass    126.45 Adult Head    127.2 Adult Eye    200.775 Adult Brain    208.8 Adult Thoracic-Abdominal Ganglion    181.2 Adult Crop    98.8 Adult Midgut    133.1 Adult Hindgut    132.8 Adult Malpighian Tubules    146.6 Adult Fat Body    118.6 Adult Salivary Gland    148.4 Adult Heart    120.775 Adult VirginFemale Spermatheca    131.9 Adult InseminatedFemale Spermatheca    125 Adult Ovary    178.1 Adult Testis    426 Adult Male Accessory Gland    152.6 Adult Carcass    124.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    145.975 Larval Midgut    162.1 Larval Hindgut    157.7 Larval Malpighian Tubules    181.9 Larval Fat Body    156.7 Larval Salivary Gland    217 Larval Trachea    165.05 Larval Carcass    126.45 Adult Head    127.2 Adult Eye    200.775 Adult Brain    208.8 Adult Thoracic-Abdominal Ganglion    181.2 Adult Crop    98.8 Adult Midgut    133.1 Adult Hindgut    132.8 Adult Malpighian Tubules    146.6 Adult Fat Body    118.6 Adult Salivary Gland    148.4 Adult Heart    120.775 Adult VirginFemale Spermatheca    131.9 Adult InseminatedFemale Spermatheca    125 Adult Ovary    178.1 Adult Testis    426 Adult Male Accessory Gland    152.6 Adult Carcass    124.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    145.975 Larval Midgut    162.1 Larval Hindgut    157.7 Larval Malpighian Tubules    181.9 Larval Fat Body    156.7 Larval Salivary Gland    217 Larval Trachea    165.05 Larval Carcass    126.45 Adult Head    127.2 Adult Eye    200.775 Adult Brain    208.8 Adult Thoracic-Abdominal Ganglion    181.2 Adult Crop    98.8 Adult Midgut    133.1 Adult Hindgut    132.8 Adult Malpighian Tubules    146.6 Adult Fat Body    118.6 Adult Salivary Gland    148.4 Adult Heart    120.775 Adult VirginFemale Spermatheca    131.9 Adult InseminatedFemale Spermatheca    125 Adult Ovary    178.1 Adult Testis    426 Adult Male Accessory Gland    152.6 Adult Carcass    124.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0033672 expression level Tissue   Expression Level Larval Central Nervous System    145.975 Larval Midgut    162.1 Larval Hindgut    157.7 Larval Malpighian Tubules    181.9 Larval Fat Body    156.7 Larval Salivary Gland    217 Larval Trachea    165.05 Larval Carcass    126.45 Adult Head    127.2 Adult Eye    200.775 Adult Brain    208.8 Adult Thoracic-Abdominal Ganglion    181.2 Adult Crop    98.8 Adult Midgut    133.1 Adult Hindgut    132.8 Adult Malpighian Tubules    146.6 Adult Fat Body    118.6 Adult Salivary Gland    148.4 Adult Heart    120.775 Adult VirginFemale Spermatheca    131.9 Adult InseminatedFemale Spermatheca    125 Adult Ovary    178.1 Adult Testis    426 Adult Male Accessory Gland    152.6 Adult Carcass    124.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    145.975 Larval Midgut    162.1 Larval Hindgut    157.7 Larval Malpighian Tubules    181.9 Larval Fat Body    156.7 Larval Salivary Gland    217 Larval Trachea    165.05 Larval Carcass    126.45 Adult Head    127.2 Adult Eye    200.775 Adult Brain    208.8 Adult Thoracic-Abdominal Ganglion    181.2 Adult Crop    98.8 Adult Midgut    133.1 Adult Hindgut    132.8 Adult Malpighian Tubules    146.6 Adult Fat Body    118.6 Adult Salivary Gland    148.4 Adult Heart    120.775 Adult VirginFemale Spermatheca    131.9 Adult InseminatedFemale Spermatheca    125 Adult Ovary    178.1 Adult Testis    426 Adult Male Accessory Gland    152.6 Adult Carcass    124.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    145.975 Larval Midgut    162.1 Larval Hindgut    157.7 Larval Malpighian Tubules    181.9 Larval Fat Body    156.7 Larval Salivary Gland    217 Larval Trachea    165.05 Larval Carcass    126.45 Adult Head    127.2 Adult Eye    200.775 Adult Brain    208.8 Adult Thoracic-Abdominal Ganglion    181.2 Adult Crop    98.8 Adult Midgut    133.1 Adult Hindgut    132.8 Adult Malpighian Tubules    146.6 Adult Fat Body    118.6 Adult Salivary Gland    148.4 Adult Heart    120.775 Adult VirginFemale Spermatheca    131.9 Adult InseminatedFemale Spermatheca    125 Adult Ovary    178.1 Adult Testis    426 Adult Male Accessory Gland    152.6 Adult Carcass    124.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    145.975 Larval Midgut    162.1 Larval Hindgut    157.7 Larval Malpighian Tubules    181.9 Larval Fat Body    156.7 Larval Salivary Gland    217 Larval Trachea    165.05 Larval Carcass    126.45 Adult Head    127.2 Adult Eye    200.775 Adult Brain    208.8 Adult Thoracic-Abdominal Ganglion    181.2 Adult Crop    98.8 Adult Midgut    133.1 Adult Hindgut    132.8 Adult Malpighian Tubules    146.6 Adult Fat Body    118.6 Adult Salivary Gland    148.4 Adult Heart    120.775 Adult VirginFemale Spermatheca    131.9 Adult InseminatedFemale Spermatheca    125 Adult Ovary    178.1 Adult Testis    426 Adult Male Accessory Gland    152.6 Adult Carcass    124.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    127.2   NA  Eye    200.775   NA  Brain    208.8   145.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    181.2   NA  Crop    98.8   162.1  Midgut    133.1   157.7  Hindgut    132.8   181.9  Malpighian Tubules    146.6   156.7  Fat Body    118.6   217  Salivary Gland    148.4   NA  Heart    120.775   165.05  Trachea    NA   NA  VirginFemale Spermatheca    131.9   NA  InseminatedFemale Spermatheca    125   NA  Ovary    178.1   NA  Testis    426   NA  Male Accessory Gland    152.6   126.45  Carcass    124.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033672 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8972-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | embryonic stage rho-7pΔ1 semi-lethal | larval stage rho-7pΔ1 semi-lethal | pupal stage rho-7pΔ1 viable rho-7CB-0229-3 viable, with Scer\GAL4pnr-MD237 rho-7GD3775 Sterility Allele male sterile rho-7CB-0229-3 rho-7pΔ1 Other Phenotypes Allele neurophysiology defective rho-7pΔ1 short lived rho-7pΔ1 uncoordinated rho-7pΔ1 Phenotype manifest in Allele eye photoreceptor cell rho-7pΔ1 indirect flight muscle rho-7pΔ1 mitochondrion rho-7CB-0229-3 rho-7pΔ1 Nebenkern rho-7CB-0229-3 rho-7pΔ1 rhabdomere rho-7pΔ1 seminal vesicle rho-7pΔ1 spermatozoon rho-7CB-0229-3 rho-7pΔ1 testis rho-7CB-0229-3
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of rho-7 Class Mutagen Stocks Known lesion rho-7CB-0229-3 1 Yes rho-7pΔ1 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of rho-7 Class Mutagen Stocks Known lesion rho-7GD3775 in vitro construct - RNAi in vitro construct - regulatory fusion 4 Yes rho-7GL00461 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rho-7KK107598 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rho-7fl.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3775} NA P{KK107598} NA P{TRiP.GL00461} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS3}rho-7CB-0229-3 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mitochondrial fusion inferred from mutant phenotype (McQuibban et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
serine-type endopeptidase activity inferred from electronic annotation with InterPro:IPR002610, InterPro:IPR022764 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR002610 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR002610, InterPro:IPR022764 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions rho-7 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62065 DroID - A comprehensive database of gene and protein interactions. • FBgn0033672 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36281
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11795 Dere\GG22614 Dgri\GH20399 Dmoj\GI19585 Dper\GL20022 Dpse\GA21446 Dsec\GM20394 Dsim\GD25869 Dvir\GJ18325 Dwil\GK22246 Dyak\GE13484
Curated drosophilid orthologs	Dpse\GA21446
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013749-PA Aedes aegypti (mosquito) AGAP002626-PA Anopheles gambiae (mosquito) XP_395657.2 Apis mellifera (honey bee) XP_001946556.1 Acyrthosiphon pisum (pea aphid) At1g18600.1 Arabidopsis thaliana (wall cress) 11066 Batrachochytrium dendrobatidis (chytrid fungus) 201921 Branchiostoma floridae (lancelet) XP_001893178.1 Brugia malayi (roundworm nematode) BGIBMGA007807-PA Bombyx mori (silk worm) ENSBTAP00000019227 Bos taurus (bovine) CAL0000015 Candida albicans (a form of yeast) CBP09783 Caenorhabditis briggsae (nematode) CE39860 Caenorhabditis elegans (worm) ENSCAFP00000017641 Canis familiaris (dog) CAGL0G07799g Candida glabrata (haploid yeast) ENSCINP00000016443 Ciona intestinalis (sea squirt) JA10171 Caenorhabditis japonica (nematode) CMP210C Cyanidioschyzon merolae (red alga) cn07051 Cryptococcus neoformans (yeast-like fungus) CPIJ015372 Culex pipens (mosquito) ENSCPOP00000012613 Cavia porcellus (guinea pig) RP41324 Caenorhabditis remanei (nematode) 153017 Capitella spl (polychaete worm) 306013 Daphnia pulex (daphnia) ENSDARP00000057438 Danio rerio (zebra fish) ENSECAP00000019941 Equus caballus (horse) ENSGACP00000005845 Gymnopilus aculeatus (mushroom) ENSGALP00000040437 Gallus gallus (chicken) 114574 Hypsipyla robusta (cedar shoot borer) ENSP00000325421 Homo sapiens (human) 160105 Lottia gigantea (owl limpet) 33494 Monocosta brevicollis (choanoflagellate) ENSMODP00000016828 Monodelphis domestica (gray opossum) ENSMMUP00000026065 Macaca mulatta (rhesus monkey) ENSMUSP00000045361 Mus musculus (house mouse) 174851 Nematostella vectensis (starlet anemone) XP_001605844.1 Nasonia vitripennis (wasp) ENSOANP00000010887 Ornithorynchus anatinus (platypus) ENSORLP00000025332 Oryzias latipes (japanese killifish) PHUM005130-PA Pediculus humanus (human body louse) ENSPPYP00000016034 Pongo pygmaeus (orangutan) 139903 Phytophthora sojae (root rot pathogen) 415712 Populus trichocarpa (black cottonwood) ENSPTRP00000026963 Pan troglodytes (chimpanzee) PVX_083160 Plasmodium vivax (protozoal parasite) ENSRNOP00000029124 Rattus norvegicus (norway rat) 5053757 Sorghum bicolor (sorghum) YGR101W Saccharomyces cerevisiae (budding yeast) SPBC13E7.11 Schizosaccharomyces pombe (fission yeast) XP_781024.1 Strongylocentrotus purpuratus (purple sea urchin) 55255 Trichoplax adhaerens (metazoa) XP_972425.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014164 Tetraodon nigroviridis (green spotted pufferfish) 4981 Thalassiosira pseudonana (marine diatom) ENSTRUP00000021892 Takifugu rubripes (pufferfish Takifugu) YALI0B23364g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11012 NV13854 LH19378 ISCW019461 FBgn0231153 FBgn0224231 FBgn0205484 FBgn0197149 FBgn0175277 JGI_V11_306013 FBgn0081433 FBgn0157619 FBgn0142322 FBgn0127862 FBgn0114785 FBgn0088835 CPIJ015372 BGIBMGA007807 ACYPI20857 ACYPI003884 GB14771 AGAP002626 AAEL013749 PHUM075920 GLEAN_13516
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	35617 y1 sc* v1; P{TRiP.GL00461}attP2
Kyoto	123082 w1118; P{RS3}rho-7CB-0229-3
VDRC	v108343 P{KK107598}VIE-260B v8763 w1118 P{GD3775}v8763 v45846 w1118 P{GD3775}v45846 v45845 w1118; P{GD3775}v45845 v45847 w1118; P{GD3775}v45847
Genomic Clones ( 1 )
	BACR14L19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 31 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH66343
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH17495
Other clones	190159 214445.17 CK01.127A.D12 EC30714 EK056905 EK097248 EK167130 EK292457 EP14954 FGH001C11 IP09565 IP11321 IP17692 IP17792 IP17892 RP004105156 RP004195056 RP004195227 RP004215719 RP004222584 RP004223202 RP004234268 RP004244541 RP004254066 RP004254835 RP004265903 RP004378316 RP004404478 RP004429906
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0033672 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36281
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CG8972 rho-7 (Wasserman et al., 2000)
Source for database merge of	Source for merge of: rho-7 anon-WO0138581.3 (FlyBase, 1996-)
Additional comments	Source for merge of rho-7 anon-WO0138581.3 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	400bp of dsRNA generated from primer-directed transcription from genomic DNA, corresponding to the gene rho-7, when transfected into S2 cells results in a majority of cells exhibiting a highly fragmented mitochondrial network. These cells do not exhibit any extra sensitivity to cyclohexamide-induced apoptosis. (McQuibban et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078980 RefSeq (Proteins) • NP_523704 DDBJ / EMBL / GenBank • AAF58598 AAM52748 AX153652 AY122236 BI625846 Entrez Gene - A searchable database of RefSeq genes. • 36281 UniProtKB/TrEMBL • A1Z8R8 Q8MQY3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S54, rhomboid (IPR002610) Peptidase S54, rhomboid domain (IPR022764)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62065 DroID - A comprehensive database of gene and protein interactions. • FBgn0033672 DRSC - Results from RNAi screens. • FBgn0033672 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0033672 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8972-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0033672 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36281 InParanoid A subset of ortholog calls from InParanoid. • AAEL013749-PA Aedes aegypti (mosquito) AGAP002626-PA Anopheles gambiae (mosquito) XP_395657.2 Apis mellifera (honey bee) XP_001946556.1 Acyrthosiphon pisum (pea aphid) At1g18600.1 Arabidopsis thaliana (wall cress) 11066 Batrachochytrium dendrobatidis (chytrid fungus) 201921 Branchiostoma floridae (lancelet) XP_001893178.1 Brugia malayi (roundworm nematode) BGIBMGA007807-PA Bombyx mori (silk worm) ENSBTAP00000019227 Bos taurus (bovine) CAL0000015 Candida albicans (a form of yeast) CBP09783 Caenorhabditis briggsae (nematode) CE39860 Caenorhabditis elegans (worm) ENSCAFP00000017641 Canis familiaris (dog) CAGL0G07799g Candida glabrata (haploid yeast) ENSCINP00000016443 Ciona intestinalis (sea squirt) JA10171 Caenorhabditis japonica (nematode) CMP210C Cyanidioschyzon merolae (red alga) cn07051 Cryptococcus neoformans (yeast-like fungus) CPIJ015372 Culex pipens (mosquito) ENSCPOP00000012613 Cavia porcellus (guinea pig) RP41324 Caenorhabditis remanei (nematode) 153017 Capitella spl (polychaete worm) 306013 Daphnia pulex (daphnia) ENSDARP00000057438 Danio rerio (zebra fish) ENSECAP00000019941 Equus caballus (horse) ENSGACP00000005845 Gymnopilus aculeatus (mushroom) ENSGALP00000040437 Gallus gallus (chicken) 114574 Hypsipyla robusta (cedar shoot borer) ENSP00000325421 Homo sapiens (human) 160105 Lottia gigantea (owl limpet) 33494 Monocosta brevicollis (choanoflagellate) ENSMODP00000016828 Monodelphis domestica (gray opossum) ENSMMUP00000026065 Macaca mulatta (rhesus monkey) ENSMUSP00000045361 Mus musculus (house mouse) 174851 Nematostella vectensis (starlet anemone) XP_001605844.1 Nasonia vitripennis (wasp) ENSOANP00000010887 Ornithorynchus anatinus (platypus) ENSORLP00000025332 Oryzias latipes (japanese killifish) PHUM005130-PA Pediculus humanus (human body louse) ENSPPYP00000016034 Pongo pygmaeus (orangutan) 139903 Phytophthora sojae (root rot pathogen) 415712 Populus trichocarpa (black cottonwood) ENSPTRP00000026963 Pan troglodytes (chimpanzee) PVX_083160 Plasmodium vivax (protozoal parasite) ENSRNOP00000029124 Rattus norvegicus (norway rat) 5053757 Sorghum bicolor (sorghum) YGR101W Saccharomyces cerevisiae (budding yeast) SPBC13E7.11 Schizosaccharomyces pombe (fission yeast) XP_781024.1 Strongylocentrotus purpuratus (purple sea urchin) 55255 Trichoplax adhaerens (metazoa) XP_972425.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014164 Tetraodon nigroviridis (green spotted pufferfish) 4981 Thalassiosira pseudonana (marine diatom) ENSTRUP00000021892 Takifugu rubripes (pufferfish Takifugu) YALI0B23364g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/rhomboid71.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36281 modMine - Data generated by the modENCODE project. • FBgn0033672 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11012 NV13854 LH19378 ISCW019461 FBgn0231153 FBgn0224231 FBgn0205484 FBgn0197149 FBgn0175277 JGI_V11_306013 FBgn0081433 FBgn0157619 FBgn0142322 FBgn0127862 FBgn0114785 FBgn0088835 CPIJ015372 BGIBMGA007807 ACYPI20857 ACYPI003884 GB14771 AGAP002626 AAEL013749 PHUM075920 GLEAN_13516
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	anon-WO0138581.3   CG8972 (Keleman et al., 2009.8.5, Ni et al., 2011.7.19) PARL (Urban, 2006) rho-7 (Zeitlinger et al., 2007) Rhomboid-7 (Whitworth et al., 2008)
Name Synonym	rhomboid-7 (Wasserman et al., 2000) Rhomboid-7 (McQuibban et al., 2006, Urban, 2006, Whitworth et al., 2008)
Secondary FlyBase IDs
	FBgn0044791
References ( 16 )
Research paper	Whitworth et al., 2008, Dis. Model Mech. 1(2-3): 168--174 Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. [FBrf0206306] McQuibban et al., 2006, Curr. Biol. 16(10): 982--989 Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. [FBrf0195303] Wasserman et al., 2000, Genes Dev. 14(13): 1651--1663 A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling. [FBrf0128677]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Zeitlinger et al., 2007, Nat. Genet. 39(12): Supplementary Information [FBrf0208880] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Review	Urban, 2006, Genes Dev. 20(22): 3054--3068 Rhomboid proteins: conserved membrane proteases with divergent biological functions. [FBrf0193506]
Personal communication to FlyBase	Ni et al., 2011.7.19, TRiP germline vector pVALIUM21. TRiP germline vector pVALIUM21. [FBrf0214641] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Abstract	Whitworth et al., 2008, A. Dros. Res. Conf. 49: 104 Rhomboid-7 and Omi are components of the Pink1/Parkin pathway which affects mitochondrial membrane dynamics. [FBrf0203805]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Patent	Tononi et al., 2001.5.31, World Patent 0138581-A: Vigilance nucleic acids and related diagnostic, screening and therapeutic methods. [FBrf0141242]