Pimet, DmHen1, piRNA methyltransferase
RNA methyltransferase - carries out methylation of small interfering RNAs, the final step in assembly of RISC occurring after the Argonaute-bound siRNA duplex is converted to single-stranded RNA
Please see the JBrowse view of Dmel\Hen1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hen1 using the Feature Mapper tool.
Comment: maternally deposited
GBrowse - Visual display of RNA-Seq signals
View Dmel\Hen1 in GBrowse 22-66
2-67.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: hen1 CG12367
Source for identity of: Pimet hen1
Source for identity of: Hen1 Pimet
FlyBase Curator comment: Renamed from 'Pimet/piRNA methyltransferase' to 'Hen1' because: i) the former is misleading because the gene product methylates both siRNAs and piRNAs in flies (see FBrf0202202); and ii) PubMed searches show that the wider research community clearly favours 'Hen1' over 'Pimet'.
hen1 is required for piRNA-directed silencing of transposable elements in the germline.
Pimet shows single-stranded small RNA methylation activity in vitro.